[Hub]/) : Traits : Waist Hip Ratio (WHR) :

chr11:61,627,881-63,284,510

Best TWAS P=8.09e-28 · Best GWAS P=2.74e-25 conditioned to 0.229

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous ROM1 0.25 0.17 lasso 3 0.18 1.5e-14 9.18 -9.3 9.6e-21 -0.91 0.05 0.95 FALSE
2 GTEx Adipose Subcutaneous EML3 0.07 0.00 enet 22 0.02 6.0e-03 2.18 9.6 1.2e-21 0.54 0.02 0.80 TRUE
3 GTEx Adipose Visceral Omentum ROM1 0.29 0.16 lasso 8 0.23 3.7e-12 10.39 -9.8 9.2e-23 -0.95 0.00 1.00 FALSE
4 GTEx Artery Aorta ROM1 0.18 0.17 lasso 7 0.16 3.3e-09 10.09 -9.8 7.9e-23 -0.94 0.03 0.97 FALSE
5 GTEx Artery Tibial ROM1 0.14 0.05 lasso 6 0.03 2.5e-03 10.10 -9.7 4.6e-22 -0.93 0.02 0.96 FALSE
6 GTEx Breast Mammary Tissue ROM1 0.10 0.09 lasso 5 0.06 5.4e-04 10.09 -10.2 1.9e-24 -0.96 0.01 0.98 FALSE
7 GTEx Breast Mammary Tissue (Male) ROM1 0.17 0.00 enet 18 0.01 2.2e-01 10.02 -7.0 2.4e-12 -0.70 0.03 0.42 FALSE
8 GTEx Breast Mammary Tissue (Female) ROM1 0.16 0.02 lasso 4 0.04 2.9e-02 10.39 -10.4 1.9e-25 -1.00 0.01 0.93 FALSE
9 GTEx Cells EBV-transformed lymphocytes EML3 0.33 0.22 lasso 8 0.21 1.6e-07 10.16 10.3 1.1e-24 0.94 0.01 0.99 FALSE
10 GTEx Cells Transformed fibroblasts GANAB 0.10 0.09 enet 25 0.08 8.8e-07 -6.61 5.2 1.6e-07 0.32 0.73 0.02 FALSE
11 GTEx Cells Transformed fibroblasts MTA2 0.06 0.09 lasso 1 0.07 3.0e-06 8.60 8.6 8.2e-18 0.82 0.06 0.94 FALSE
12 GTEx Cells Transformed fibroblasts EML3 0.19 0.16 lasso 9 0.18 7.3e-14 8.62 9.5 1.5e-21 0.90 0.05 0.95 FALSE
13 GTEx Cells Transformed fibroblasts HNRNPUL2 0.11 0.04 enet 14 0.05 9.8e-05 3.88 -5.7 1.4e-08 -0.58 0.93 0.00 FALSE
14 GTEx Esophagus Mucosa MTA2 0.29 0.34 lasso 5 0.33 6.9e-23 10.15 10.1 4.4e-24 0.94 0.02 0.98 FALSE
15 GTEx Esophagus Mucosa EML3 0.40 0.43 lasso 8 0.46 1.8e-33 10.11 9.8 6.9e-23 0.94 0.03 0.97 FALSE
16 GTEx Heart Atrial Appendage TUT1 0.14 -0.01 enet 11 0.00 2.7e-01 0.74 -5.2 1.8e-07 -0.46 0.05 0.27 FALSE
17 GTEx Lung ROM1 0.25 0.18 enet 13 0.20 2.2e-15 10.10 -9.9 6.3e-23 -0.93 0.03 0.97 FALSE
18 GTEx Lung EML3 0.07 0.04 lasso 3 0.01 2.5e-02 10.02 10.1 5.0e-24 0.94 0.03 0.93 FALSE
19 GTEx Nerve Tibial GANAB 0.21 0.14 lasso 4 0.14 1.8e-10 -6.61 6.4 1.7e-10 0.31 1.00 0.00 FALSE
20 GTEx Nerve Tibial ROM1 0.15 0.06 lasso 7 0.06 2.9e-05 9.26 -7.8 6.7e-15 -0.84 0.03 0.97 FALSE
21 GTEx Nerve Tibial EML3 0.17 0.10 lasso 4 0.09 3.9e-07 10.02 9.6 9.0e-22 0.92 0.06 0.94 FALSE
22 GTEx Nerve Tibial B3GAT3 0.18 0.11 lasso 3 0.09 4.7e-07 6.81 6.7 2.4e-11 0.65 0.85 0.11 FALSE
23 GTEx Ovary ROM1 0.25 0.00 lasso 5 0.00 3.3e-01 8.60 -9.3 9.5e-21 -0.89 0.03 0.71 FALSE
24 GTEx Pituitary STX5 0.22 0.11 lasso 3 0.11 9.7e-04 3.62 -7.7 1.4e-14 -0.54 0.04 0.57 FALSE
25 GTEx Skin Not Sun Exposed Suprapubic ROM1 0.15 0.08 lasso 1 0.06 2.8e-04 7.10 -7.1 1.2e-12 -0.68 0.06 0.67 FALSE
26 GTEx Skin Not Sun Exposed Suprapubic EML3 0.20 0.19 lasso 3 0.24 2.7e-13 10.02 9.6 1.1e-21 0.92 0.05 0.95 FALSE
27 GTEx Skin Not Sun Exposed Suprapubic B3GAT3 0.18 0.11 lasso 3 0.11 9.8e-07 6.81 7.7 1.4e-14 0.75 0.76 0.22 FALSE
28 GTEx Skin Sun Exposed Lower leg MTA2 0.14 0.04 enet 21 0.05 3.1e-05 9.18 7.8 8.6e-15 0.76 0.02 0.98 FALSE
29 GTEx Skin Sun Exposed Lower leg ROM1 0.13 0.11 lasso 4 0.10 9.7e-09 10.10 -10.5 1.2e-25 -0.94 0.03 0.97 FALSE
30 GTEx Skin Sun Exposed Lower leg EML3 0.32 0.25 enet 19 0.26 8.0e-22 10.02 10.0 9.6e-24 0.94 0.01 0.99 FALSE
31 GTEx Spleen GANAB 0.35 -0.01 lasso 9 0.01 1.3e-01 10.02 9.1 7.4e-20 0.83 0.03 0.68 FALSE
32 GTEx Spleen MTA2 0.26 0.07 enet 19 0.07 8.7e-03 10.39 7.0 3.2e-12 0.84 0.00 0.97 FALSE
33 GTEx Stomach EML3 0.11 0.04 enet 5 0.03 2.1e-02 8.42 9.5 2.3e-21 0.90 0.03 0.79 FALSE
34 GTEx Testis EML3 0.27 0.22 enet 15 0.29 2.7e-13 10.15 9.8 1.2e-22 0.93 0.03 0.97 FALSE
35 GTEx Thyroid ROM1 0.17 0.16 lasso 8 0.16 3.6e-12 10.02 -9.9 5.0e-23 -0.94 0.03 0.97 FALSE
36 GTEx Thyroid EML3 0.10 0.11 lasso 4 0.10 5.9e-08 10.02 10.0 1.5e-23 0.94 0.04 0.96 FALSE
37 GTEx Thyroid B3GAT3 0.18 0.09 lasso 5 0.12 1.4e-09 6.81 5.9 3.0e-09 0.67 0.56 0.44 FALSE
38 GTEx Whole Blood EML3 0.17 0.09 lasso 7 0.08 6.3e-08 10.09 10.0 1.0e-23 0.94 0.02 0.98 FALSE
39 METSIM Adipose B3GAT3 0.08 0.06 enet 16 0.07 5.4e-11 8.27 7.3 3.1e-13 0.79 0.22 0.78 FALSE
40 METSIM Adipose EEF1G 0.08 0.05 bslmm 375 0.06 4.5e-09 9.26 -7.9 2.9e-15 -0.85 0.04 0.96 FALSE
41 METSIM Adipose EML3 0.15 0.14 bslmm 376 0.14 1.9e-20 10.08 10.6 5.0e-26 0.92 0.03 0.97 FALSE
42 METSIM Adipose ROM1 0.05 0.02 enet 17 0.02 9.9e-05 10.15 -7.8 5.7e-15 -0.79 0.03 0.97 FALSE
43 METSIM Adipose TTC9C 0.07 0.07 enet 25 0.08 1.4e-12 3.92 6.1 1.4e-09 0.67 0.99 0.01 FALSE
44 ROSMAP Brain Pre-frontal Cortex GANAB 0.05 0.07 lasso 2 0.05 1.3e-07 -6.61 6.2 6.5e-10 0.33 0.99 0.00 FALSE
45 YFS Blood EEF1G 0.30 0.45 lasso 6 0.45 3.6e-166 10.09 -10.0 1.0e-23 -0.94 0.03 0.97 FALSE
46 YFS Blood EML3 0.20 0.31 lasso 12 0.33 1.3e-110 9.26 9.6 5.4e-22 0.93 0.07 0.93 FALSE
47 YFS Blood INTS5 0.09 0.12 lasso 4 0.12 1.9e-38 6.81 8.1 6.5e-16 0.79 1.00 0.00 FALSE
48 The Cancer Genome Atlas Bladder Urothelial Carcinoma EEF1G 0.04 0.05 lasso 1 0.04 1.1e-04 9.18 -9.2 4.3e-20 -0.90 0.02 0.96 FALSE
49 The Cancer Genome Atlas Breast Invasive Carcinoma C11orf83 0.01 0.00 blup 23 0.01 4.2e-03 8.27 -6.8 1.1e-11 -0.71 0.01 0.73 FALSE
50 The Cancer Genome Atlas Breast Invasive Carcinoma EEF1G 0.02 0.04 lasso 2 0.03 6.3e-07 10.11 -10.1 3.8e-24 -0.95 0.02 0.98 FALSE
51 The Cancer Genome Atlas Breast Invasive Carcinoma EML3 0.02 0.02 lasso 4 0.02 2.5e-05 9.26 9.3 1.2e-20 0.92 0.01 0.99 FALSE
52 The Cancer Genome Atlas Breast Invasive Carcinoma ROM1 0.01 0.02 enet 4 0.02 2.4e-04 9.18 -8.5 2.2e-17 -0.88 0.01 0.96 FALSE
53 The Cancer Genome Atlas Colon Adenocarcinoma EEF1G 0.07 0.11 lasso 1 0.11 9.2e-07 10.16 -10.2 3.0e-24 -0.96 0.01 0.99 FALSE
54 The Cancer Genome Atlas Colon Adenocarcinoma EML3 0.07 0.03 blup 29 0.05 6.5e-04 8.60 9.9 3.6e-23 0.87 0.01 0.92 FALSE
55 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma EEF1G 0.10 0.09 blup 26 0.09 9.8e-11 10.16 -10.9 8.1e-28 -0.88 0.01 0.99 TRUE
56 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma EML3 0.06 0.05 blup 27 0.06 7.6e-07 8.22 8.0 9.1e-16 0.86 0.04 0.95 FALSE
57 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ROM1 0.04 0.02 blup 22 0.02 6.2e-03 8.60 -8.9 7.6e-19 -0.86 0.01 0.86 FALSE
58 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EEF1G 0.11 0.12 blup 27 0.13 5.5e-14 10.10 -9.1 7.0e-20 -0.91 0.03 0.97 FALSE
59 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma EML3 0.04 0.06 lasso 3 0.06 1.7e-07 10.02 10.0 1.0e-23 0.94 0.01 0.99 FALSE
60 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma EEF1G 0.07 0.04 blup 28 0.07 9.8e-05 8.60 -8.7 5.0e-18 -0.90 0.02 0.93 FALSE
61 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma EML3 0.06 0.09 lasso 2 0.08 1.6e-05 8.27 8.5 2.2e-17 0.82 0.05 0.94 FALSE
62 The Cancer Genome Atlas Brain Lower Grade Glioma C11orf83 0.02 0.01 blup 24 0.01 1.5e-02 8.18 -6.8 9.6e-12 -0.73 0.00 0.93 FALSE
63 The Cancer Genome Atlas Brain Lower Grade Glioma EEF1G 0.06 0.07 blup 27 0.07 8.1e-09 10.08 -9.8 1.1e-22 -0.91 0.02 0.98 FALSE
64 The Cancer Genome Atlas Brain Lower Grade Glioma EML3 0.03 0.04 blup 28 0.03 7.6e-05 9.26 10.5 7.2e-26 0.93 0.01 0.98 FALSE
65 The Cancer Genome Atlas Liver Hepatocellular Carcinoma EEF1G 0.06 0.03 blup 27 0.04 4.5e-03 8.27 -9.1 1.2e-19 -0.92 0.02 0.65 FALSE
66 The Cancer Genome Atlas Lung Adenocarcinoma EEF1G 0.06 0.08 lasso 8 0.08 5.9e-10 10.08 -9.7 2.0e-22 -0.91 0.03 0.97 FALSE
67 The Cancer Genome Atlas Lung Adenocarcinoma EML3 0.03 0.03 blup 28 0.03 8.4e-05 10.08 9.8 1.2e-22 0.93 0.01 0.99 FALSE
68 The Cancer Genome Atlas Lung Adenocarcinoma ROM1 0.04 0.04 blup 23 0.04 9.5e-06 10.11 -9.9 3.0e-23 -0.92 0.01 0.99 FALSE
69 The Cancer Genome Atlas Lung Squamous Cell Carcinoma C11orf83 0.07 0.01 blup 24 0.01 1.0e-02 6.81 -7.4 1.3e-13 -0.67 0.01 0.83 FALSE
70 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EEF1G 0.08 0.13 lasso 4 0.12 3.1e-13 10.09 -10.1 6.3e-24 -0.94 0.03 0.97 FALSE
71 The Cancer Genome Atlas Lung Squamous Cell Carcinoma EML3 0.04 0.05 blup 27 0.05 3.5e-06 9.18 10.7 1.6e-26 0.90 0.01 0.98 FALSE
72 The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma EML3 0.03 0.02 blup 27 0.03 3.5e-03 9.18 9.2 2.9e-20 0.91 0.01 0.78 FALSE
73 The Cancer Genome Atlas Pancreatic Adenocarcinoma C11orf83 0.11 0.01 lasso 3 0.02 4.0e-02 -0.82 -5.9 4.2e-09 -0.54 0.00 0.60 FALSE
74 The Cancer Genome Atlas Pancreatic Adenocarcinoma EEF1G 0.08 0.08 blup 27 0.05 3.6e-03 10.08 -10.4 2.8e-25 -0.93 0.02 0.93 FALSE
75 The Cancer Genome Atlas Pancreatic Adenocarcinoma ROM1 0.16 0.08 blup 23 0.07 5.7e-04 10.15 -8.7 4.7e-18 -0.75 0.01 0.90 FALSE
76 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma EEF1G 0.08 0.00 blup 27 0.04 1.3e-02 10.08 -10.9 1.7e-27 -0.90 0.01 0.85 FALSE
77 The Cancer Genome Atlas Prostate Adenocarcinoma C11orf83 0.03 0.03 blup 24 0.02 5.5e-03 7.08 -7.5 9.5e-14 -0.73 0.03 0.89 FALSE
78 The Cancer Genome Atlas Prostate Adenocarcinoma EEF1G 0.08 0.13 lasso 2 0.12 1.8e-12 10.09 -10.1 6.4e-24 -0.94 0.02 0.98 FALSE
79 The Cancer Genome Atlas Prostate Adenocarcinoma EML3 0.09 0.14 lasso 1 0.14 3.4e-14 9.18 9.2 4.3e-20 0.90 0.24 0.76 FALSE
80 The Cancer Genome Atlas Rectum Adenocarcinoma EML3 0.36 0.08 blup 27 0.19 3.7e-05 9.26 10.4 1.8e-25 0.81 0.01 0.83 FALSE
81 The Cancer Genome Atlas Soft Tissue Sarcoma ROM1 0.06 0.05 blup 24 0.03 8.1e-03 10.11 -9.4 7.7e-21 -0.92 0.01 0.90 FALSE
82 The Cancer Genome Atlas Skin Cutaneous Melanoma EML3 0.32 0.03 lasso 2 0.07 4.9e-03 8.42 7.7 1.4e-14 0.73 0.01 0.55 FALSE
83 The Cancer Genome Atlas Skin Cutaneous Melanoma ROM1 0.35 0.12 blup 24 0.14 1.1e-04 10.15 -8.4 4.4e-17 -0.71 0.01 0.91 FALSE
84 The Cancer Genome Atlas Stomach Adenocarcinoma EEF1G 0.05 0.07 blup 27 0.07 1.7e-05 10.16 -10.5 5.8e-26 -0.95 0.01 0.99 FALSE
85 The Cancer Genome Atlas Stomach Adenocarcinoma ROM1 0.05 0.08 lasso 3 0.08 3.1e-06 10.02 -9.9 6.1e-23 -0.93 0.01 0.99 FALSE
86 The Cancer Genome Atlas Thyroid Carcinoma ASRGL1 0.04 0.00 blup 74 0.01 8.6e-02 -6.68 -6.4 1.7e-10 0.00 0.04 0.10 TRUE
87 The Cancer Genome Atlas Thyroid Carcinoma EEF1G 0.15 0.27 blup 27 0.28 3.6e-27 10.14 -9.2 3.8e-20 -0.89 0.02 0.98 FALSE
88 The Cancer Genome Atlas Thyroid Carcinoma EML3 0.11 0.10 blup 28 0.12 2.3e-11 9.18 9.3 1.5e-20 0.86 0.16 0.84 FALSE
89 The Cancer Genome Atlas Thyroid Carcinoma ROM1 0.03 0.02 blup 23 0.02 1.1e-02 10.15 -9.2 4.1e-20 -0.91 0.01 0.94 FALSE