[Hub]/) : Traits : Waist Hip Ratio (WHR) : ← →

chr11:61,627,881-63,284,510

Best TWAS P=8.09e-28 · Best GWAS P=2.74e-25 conditioned to 0.229

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Adipose Subcutaneous	ROM1	0.25	0.17	lasso	3	0.18	1.5e-14	9.18	-9.3	9.6e-21	-0.91	0.05	0.95	FALSE
2	GTEx	Adipose Subcutaneous	EML3	0.07	0.00	enet	22	0.02	6.0e-03	2.18	9.6	1.2e-21	0.54	0.02	0.80	TRUE
3	GTEx	Adipose Visceral Omentum	ROM1	0.29	0.16	lasso	8	0.23	3.7e-12	10.39	-9.8	9.2e-23	-0.95	0.00	1.00	FALSE
4	GTEx	Artery Aorta	ROM1	0.18	0.17	lasso	7	0.16	3.3e-09	10.09	-9.8	7.9e-23	-0.94	0.03	0.97	FALSE
5	GTEx	Artery Tibial	ROM1	0.14	0.05	lasso	6	0.03	2.5e-03	10.10	-9.7	4.6e-22	-0.93	0.02	0.96	FALSE
6	GTEx	Breast Mammary Tissue	ROM1	0.10	0.09	lasso	5	0.06	5.4e-04	10.09	-10.2	1.9e-24	-0.96	0.01	0.98	FALSE
7	GTEx	Breast Mammary Tissue (Male)	ROM1	0.17	0.00	enet	18	0.01	2.2e-01	10.02	-7.0	2.4e-12	-0.70	0.03	0.42	FALSE
8	GTEx	Breast Mammary Tissue (Female)	ROM1	0.16	0.02	lasso	4	0.04	2.9e-02	10.39	-10.4	1.9e-25	-1.00	0.01	0.93	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	EML3	0.33	0.22	lasso	8	0.21	1.6e-07	10.16	10.3	1.1e-24	0.94	0.01	0.99	FALSE
10	GTEx	Cells Transformed fibroblasts	GANAB	0.10	0.09	enet	25	0.08	8.8e-07	-6.61	5.2	1.6e-07	0.32	0.73	0.02	FALSE
11	GTEx	Cells Transformed fibroblasts	MTA2	0.06	0.09	lasso	1	0.07	3.0e-06	8.60	8.6	8.2e-18	0.82	0.06	0.94	FALSE
12	GTEx	Cells Transformed fibroblasts	EML3	0.19	0.16	lasso	9	0.18	7.3e-14	8.62	9.5	1.5e-21	0.90	0.05	0.95	FALSE
13	GTEx	Cells Transformed fibroblasts	HNRNPUL2	0.11	0.04	enet	14	0.05	9.8e-05	3.88	-5.7	1.4e-08	-0.58	0.93	0.00	FALSE
14	GTEx	Esophagus Mucosa	MTA2	0.29	0.34	lasso	5	0.33	6.9e-23	10.15	10.1	4.4e-24	0.94	0.02	0.98	FALSE
15	GTEx	Esophagus Mucosa	EML3	0.40	0.43	lasso	8	0.46	1.8e-33	10.11	9.8	6.9e-23	0.94	0.03	0.97	FALSE
16	GTEx	Heart Atrial Appendage	TUT1	0.14	-0.01	enet	11	0.00	2.7e-01	0.74	-5.2	1.8e-07	-0.46	0.05	0.27	FALSE
17	GTEx	Lung	ROM1	0.25	0.18	enet	13	0.20	2.2e-15	10.10	-9.9	6.3e-23	-0.93	0.03	0.97	FALSE
18	GTEx	Lung	EML3	0.07	0.04	lasso	3	0.01	2.5e-02	10.02	10.1	5.0e-24	0.94	0.03	0.93	FALSE
19	GTEx	Nerve Tibial	GANAB	0.21	0.14	lasso	4	0.14	1.8e-10	-6.61	6.4	1.7e-10	0.31	1.00	0.00	FALSE
20	GTEx	Nerve Tibial	ROM1	0.15	0.06	lasso	7	0.06	2.9e-05	9.26	-7.8	6.7e-15	-0.84	0.03	0.97	FALSE
21	GTEx	Nerve Tibial	EML3	0.17	0.10	lasso	4	0.09	3.9e-07	10.02	9.6	9.0e-22	0.92	0.06	0.94	FALSE
22	GTEx	Nerve Tibial	B3GAT3	0.18	0.11	lasso	3	0.09	4.7e-07	6.81	6.7	2.4e-11	0.65	0.85	0.11	FALSE
23	GTEx	Ovary	ROM1	0.25	0.00	lasso	5	0.00	3.3e-01	8.60	-9.3	9.5e-21	-0.89	0.03	0.71	FALSE
24	GTEx	Pituitary	STX5	0.22	0.11	lasso	3	0.11	9.7e-04	3.62	-7.7	1.4e-14	-0.54	0.04	0.57	FALSE
25	GTEx	Skin Not Sun Exposed Suprapubic	ROM1	0.15	0.08	lasso	1	0.06	2.8e-04	7.10	-7.1	1.2e-12	-0.68	0.06	0.67	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	EML3	0.20	0.19	lasso	3	0.24	2.7e-13	10.02	9.6	1.1e-21	0.92	0.05	0.95	FALSE
27	GTEx	Skin Not Sun Exposed Suprapubic	B3GAT3	0.18	0.11	lasso	3	0.11	9.8e-07	6.81	7.7	1.4e-14	0.75	0.76	0.22	FALSE
28	GTEx	Skin Sun Exposed Lower leg	MTA2	0.14	0.04	enet	21	0.05	3.1e-05	9.18	7.8	8.6e-15	0.76	0.02	0.98	FALSE
29	GTEx	Skin Sun Exposed Lower leg	ROM1	0.13	0.11	lasso	4	0.10	9.7e-09	10.10	-10.5	1.2e-25	-0.94	0.03	0.97	FALSE
30	GTEx	Skin Sun Exposed Lower leg	EML3	0.32	0.25	enet	19	0.26	8.0e-22	10.02	10.0	9.6e-24	0.94	0.01	0.99	FALSE
31	GTEx	Spleen	GANAB	0.35	-0.01	lasso	9	0.01	1.3e-01	10.02	9.1	7.4e-20	0.83	0.03	0.68	FALSE
32	GTEx	Spleen	MTA2	0.26	0.07	enet	19	0.07	8.7e-03	10.39	7.0	3.2e-12	0.84	0.00	0.97	FALSE
33	GTEx	Stomach	EML3	0.11	0.04	enet	5	0.03	2.1e-02	8.42	9.5	2.3e-21	0.90	0.03	0.79	FALSE
34	GTEx	Testis	EML3	0.27	0.22	enet	15	0.29	2.7e-13	10.15	9.8	1.2e-22	0.93	0.03	0.97	FALSE
35	GTEx	Thyroid	ROM1	0.17	0.16	lasso	8	0.16	3.6e-12	10.02	-9.9	5.0e-23	-0.94	0.03	0.97	FALSE
36	GTEx	Thyroid	EML3	0.10	0.11	lasso	4	0.10	5.9e-08	10.02	10.0	1.5e-23	0.94	0.04	0.96	FALSE
37	GTEx	Thyroid	B3GAT3	0.18	0.09	lasso	5	0.12	1.4e-09	6.81	5.9	3.0e-09	0.67	0.56	0.44	FALSE
38	GTEx	Whole Blood	EML3	0.17	0.09	lasso	7	0.08	6.3e-08	10.09	10.0	1.0e-23	0.94	0.02	0.98	FALSE
39	METSIM	Adipose	B3GAT3	0.08	0.06	enet	16	0.07	5.4e-11	8.27	7.3	3.1e-13	0.79	0.22	0.78	FALSE
40	METSIM	Adipose	EEF1G	0.08	0.05	bslmm	375	0.06	4.5e-09	9.26	-7.9	2.9e-15	-0.85	0.04	0.96	FALSE
41	METSIM	Adipose	EML3	0.15	0.14	bslmm	376	0.14	1.9e-20	10.08	10.6	5.0e-26	0.92	0.03	0.97	FALSE
42	METSIM	Adipose	ROM1	0.05	0.02	enet	17	0.02	9.9e-05	10.15	-7.8	5.7e-15	-0.79	0.03	0.97	FALSE
43	METSIM	Adipose	TTC9C	0.07	0.07	enet	25	0.08	1.4e-12	3.92	6.1	1.4e-09	0.67	0.99	0.01	FALSE
44	ROSMAP	Brain Pre-frontal Cortex	GANAB	0.05	0.07	lasso	2	0.05	1.3e-07	-6.61	6.2	6.5e-10	0.33	0.99	0.00	FALSE
45	YFS	Blood	EEF1G	0.30	0.45	lasso	6	0.45	3.6e-166	10.09	-10.0	1.0e-23	-0.94	0.03	0.97	FALSE
46	YFS	Blood	EML3	0.20	0.31	lasso	12	0.33	1.3e-110	9.26	9.6	5.4e-22	0.93	0.07	0.93	FALSE
47	YFS	Blood	INTS5	0.09	0.12	lasso	4	0.12	1.9e-38	6.81	8.1	6.5e-16	0.79	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EEF1G	0.04	0.05	lasso	1	0.04	1.1e-04	9.18	-9.2	4.3e-20	-0.90	0.02	0.96	FALSE
49	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf83	0.01	0.00	blup	23	0.01	4.2e-03	8.27	-6.8	1.1e-11	-0.71	0.01	0.73	FALSE
50	The Cancer Genome Atlas	Breast Invasive Carcinoma	EEF1G	0.02	0.04	lasso	2	0.03	6.3e-07	10.11	-10.1	3.8e-24	-0.95	0.02	0.98	FALSE
51	The Cancer Genome Atlas	Breast Invasive Carcinoma	EML3	0.02	0.02	lasso	4	0.02	2.5e-05	9.26	9.3	1.2e-20	0.92	0.01	0.99	FALSE
52	The Cancer Genome Atlas	Breast Invasive Carcinoma	ROM1	0.01	0.02	enet	4	0.02	2.4e-04	9.18	-8.5	2.2e-17	-0.88	0.01	0.96	FALSE
53	The Cancer Genome Atlas	Colon Adenocarcinoma	EEF1G	0.07	0.11	lasso	1	0.11	9.2e-07	10.16	-10.2	3.0e-24	-0.96	0.01	0.99	FALSE
54	The Cancer Genome Atlas	Colon Adenocarcinoma	EML3	0.07	0.03	blup	29	0.05	6.5e-04	8.60	9.9	3.6e-23	0.87	0.01	0.92	FALSE
55	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EEF1G	0.10	0.09	blup	26	0.09	9.8e-11	10.16	-10.9	8.1e-28	-0.88	0.01	0.99	TRUE
56	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	EML3	0.06	0.05	blup	27	0.06	7.6e-07	8.22	8.0	9.1e-16	0.86	0.04	0.95	FALSE
57	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ROM1	0.04	0.02	blup	22	0.02	6.2e-03	8.60	-8.9	7.6e-19	-0.86	0.01	0.86	FALSE
58	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EEF1G	0.11	0.12	blup	27	0.13	5.5e-14	10.10	-9.1	7.0e-20	-0.91	0.03	0.97	FALSE
59	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EML3	0.04	0.06	lasso	3	0.06	1.7e-07	10.02	10.0	1.0e-23	0.94	0.01	0.99	FALSE
60	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EEF1G	0.07	0.04	blup	28	0.07	9.8e-05	8.60	-8.7	5.0e-18	-0.90	0.02	0.93	FALSE
61	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EML3	0.06	0.09	lasso	2	0.08	1.6e-05	8.27	8.5	2.2e-17	0.82	0.05	0.94	FALSE
62	The Cancer Genome Atlas	Brain Lower Grade Glioma	C11orf83	0.02	0.01	blup	24	0.01	1.5e-02	8.18	-6.8	9.6e-12	-0.73	0.00	0.93	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	EEF1G	0.06	0.07	blup	27	0.07	8.1e-09	10.08	-9.8	1.1e-22	-0.91	0.02	0.98	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	EML3	0.03	0.04	blup	28	0.03	7.6e-05	9.26	10.5	7.2e-26	0.93	0.01	0.98	FALSE
65	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EEF1G	0.06	0.03	blup	27	0.04	4.5e-03	8.27	-9.1	1.2e-19	-0.92	0.02	0.65	FALSE
66	The Cancer Genome Atlas	Lung Adenocarcinoma	EEF1G	0.06	0.08	lasso	8	0.08	5.9e-10	10.08	-9.7	2.0e-22	-0.91	0.03	0.97	FALSE
67	The Cancer Genome Atlas	Lung Adenocarcinoma	EML3	0.03	0.03	blup	28	0.03	8.4e-05	10.08	9.8	1.2e-22	0.93	0.01	0.99	FALSE
68	The Cancer Genome Atlas	Lung Adenocarcinoma	ROM1	0.04	0.04	blup	23	0.04	9.5e-06	10.11	-9.9	3.0e-23	-0.92	0.01	0.99	FALSE
69	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C11orf83	0.07	0.01	blup	24	0.01	1.0e-02	6.81	-7.4	1.3e-13	-0.67	0.01	0.83	FALSE
70	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EEF1G	0.08	0.13	lasso	4	0.12	3.1e-13	10.09	-10.1	6.3e-24	-0.94	0.03	0.97	FALSE
71	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EML3	0.04	0.05	blup	27	0.05	3.5e-06	9.18	10.7	1.6e-26	0.90	0.01	0.98	FALSE
72	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EML3	0.03	0.02	blup	27	0.03	3.5e-03	9.18	9.2	2.9e-20	0.91	0.01	0.78	FALSE
73	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C11orf83	0.11	0.01	lasso	3	0.02	4.0e-02	-0.82	-5.9	4.2e-09	-0.54	0.00	0.60	FALSE
74	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EEF1G	0.08	0.08	blup	27	0.05	3.6e-03	10.08	-10.4	2.8e-25	-0.93	0.02	0.93	FALSE
75	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	ROM1	0.16	0.08	blup	23	0.07	5.7e-04	10.15	-8.7	4.7e-18	-0.75	0.01	0.90	FALSE
76	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EEF1G	0.08	0.00	blup	27	0.04	1.3e-02	10.08	-10.9	1.7e-27	-0.90	0.01	0.85	FALSE
77	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf83	0.03	0.03	blup	24	0.02	5.5e-03	7.08	-7.5	9.5e-14	-0.73	0.03	0.89	FALSE
78	The Cancer Genome Atlas	Prostate Adenocarcinoma	EEF1G	0.08	0.13	lasso	2	0.12	1.8e-12	10.09	-10.1	6.4e-24	-0.94	0.02	0.98	FALSE
79	The Cancer Genome Atlas	Prostate Adenocarcinoma	EML3	0.09	0.14	lasso	1	0.14	3.4e-14	9.18	9.2	4.3e-20	0.90	0.24	0.76	FALSE
80	The Cancer Genome Atlas	Rectum Adenocarcinoma	EML3	0.36	0.08	blup	27	0.19	3.7e-05	9.26	10.4	1.8e-25	0.81	0.01	0.83	FALSE
81	The Cancer Genome Atlas	Soft Tissue Sarcoma	ROM1	0.06	0.05	blup	24	0.03	8.1e-03	10.11	-9.4	7.7e-21	-0.92	0.01	0.90	FALSE
82	The Cancer Genome Atlas	Skin Cutaneous Melanoma	EML3	0.32	0.03	lasso	2	0.07	4.9e-03	8.42	7.7	1.4e-14	0.73	0.01	0.55	FALSE
83	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ROM1	0.35	0.12	blup	24	0.14	1.1e-04	10.15	-8.4	4.4e-17	-0.71	0.01	0.91	FALSE
84	The Cancer Genome Atlas	Stomach Adenocarcinoma	EEF1G	0.05	0.07	blup	27	0.07	1.7e-05	10.16	-10.5	5.8e-26	-0.95	0.01	0.99	FALSE
85	The Cancer Genome Atlas	Stomach Adenocarcinoma	ROM1	0.05	0.08	lasso	3	0.08	3.1e-06	10.02	-9.9	6.1e-23	-0.93	0.01	0.99	FALSE
86	The Cancer Genome Atlas	Thyroid Carcinoma	ASRGL1	0.04	0.00	blup	74	0.01	8.6e-02	-6.68	-6.4	1.7e-10	0.00	0.04	0.10	TRUE
87	The Cancer Genome Atlas	Thyroid Carcinoma	EEF1G	0.15	0.27	blup	27	0.28	3.6e-27	10.14	-9.2	3.8e-20	-0.89	0.02	0.98	FALSE
88	The Cancer Genome Atlas	Thyroid Carcinoma	EML3	0.11	0.10	blup	28	0.12	2.3e-11	9.18	9.3	1.5e-20	0.86	0.16	0.84	FALSE
89	The Cancer Genome Atlas	Thyroid Carcinoma	ROM1	0.03	0.02	blup	23	0.02	1.1e-02	10.15	-9.2	4.1e-20	-0.91	0.01	0.94	FALSE