Hub : Genes

MNS1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.049 0.022 0.00071 0.024 0.024 0.018 0.023 0.018 0.00049 0.00058 0.0027 0.00076 0.0024
2 GTEx Adipose Subcutaneous 0.089 0.041 0.00140 -0.003 NA 0.015 NA -0.003 0.71000 NA 0.0190 NA 0.6800

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.7 1.1 2.1 -0.2 1.4
Bipolar Disorder or Schizophrenia 3.3 8.1 15.9 0.5 4.0
Depressed Affect (Nagel 2018) 1.0 2.2 3.5 0.9 -1.9
Depression (Nagel 2018) 0.5 0.7 1.1 -0.6 -1.0
Intelligence (Savage-Jansen 2018) 0.2 0.7 1.4 0.1 -1.2
Neuroticism (Nagel 2018) 2.2 5.2 7.4 1.7 -2.7
Schizophrenia (2018) 4.0 8.3 16.1 0.7 4.0
Schizophrenia vs Biploar Disorder 1.1 1.4 1.9 1.4 1.0
Worry (Nagel 2018) 3.7 7.9 14.3 1.2 -3.8
Alzheimer’s Disease (in mother) 0.9 1.0 2.0 -0.1 -1.4
Alzheimer’s Disease (in father) 2.8 3.0 6.0 2.5 -0.0
Alzheimer’s Disease (including proxy) 0.3 0.4 0.7 0.9 -0.3
Crohns Disease (2017) 1.0 2.1 4.0 2.0 0.5
Irritable Bowel Disease (IBD) 0.8 1.8 3.6 1.9 -0.3
Ulcerative Colitis (UC) 0.5 1.0 1.3 1.1 -0.8
Major Depression (MDD) 0.4 0.5 1.0 -1.0 -0.0
Reaction Time 1.0 1.9 3.7 -1.9 -0.1
Verbal and Numeric Reasoning (VNR) 0.3 0.8 0.9 0.8 -1.0
Breast Cancer 0.0 0.0 0.0 -0.1 0.2
Ovarian Cancer 0.4 0.5 1.0 0.1 -1.0
Prostate Cancer 0.6 0.8 1.1 -0.6 -1.1
Age at First Birth 1.7 2.5 4.7 0.6 2.2
Bipolar Disorder (2011) 2.4 2.3 4.5 -0.4 2.1
Body Mass Index (BMI) (2010) 0.3 0.4 0.8 0.9 -0.1
Coronary Artery Disease (CAD) 0.6 0.7 1.4 1.2 -0.1
Crohns Disease (2012) 1.0 1.7 2.7 0.8 1.6
Mean Putamen Volume 0.3 0.4 0.4 0.6 0.7
Fasting Glucose 0.3 0.3 0.4 -0.6 0.5
HbA1C 2.3 2.5 3.6 1.9 -1.2
HDL Cholesterol 0.1 0.2 0.3 -0.3 0.5
LDL Cholesterol 1.3 2.0 2.4 1.3 -1.5
Lupus 0.1 0.2 0.3 -0.2 0.5
Neuroticism (2016) 0.0 0.1 0.1 -0.3 -0.2
Primary Biliary Cirrhosis 0.2 0.2 0.2 -0.5 -0.5
Rheumatoid Arthritis 0.6 0.9 1.5 -0.5 -1.2
Schizophrenia (2014) 3.9 8.7 16.8 0.8 4.1
Triglycerides 1.6 2.6 4.9 2.2 -0.6
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.5 0.0 1.2
Ulcerative Colitis 0.4 0.5 1.0 1.0 -0.0
Blood Eosinophil Count 0.2 1.5 2.6 -0.6 1.6
Blood Platelet Count 0.6 7.2 11.8 1.6 3.4
Blood Red Count 0.4 4.0 6.9 -1.1 2.6
Blood White Count 0.2 1.8 3.2 -1.8 -0.7
Heel T-Score 1.1 8.4 16.5 0.6 4.1
BMI 0.5 3.2 4.4 2.1 -1.4
Height 0.1 2.4 2.5 -1.6 1.5
Waist Hip Ratio (WHR) 7.7 34.5 69.0 -8.3 0.1
Systolic Blood Pressure 0.3 1.7 3.1 0.5 1.8
Smoking Status 1.7 4.1 7.9 -2.8 0.5
Allergy or Eczema 0.0 0.1 0.2 -0.1 0.4
Cardiovascular Disease 0.3 0.8 0.9 -0.9 -0.9
Hypothyroidism (self reported) 0.2 0.6 1.0 -0.3 -1.0
Respiratory disease 1.2 2.7 4.5 1.0 2.1
Type 2 Diabetes (T2D) (2018) 0.4 0.8 1.4 0.5 -1.2
Lung FEV1/FVC ratio 0.2 1.2 1.6 1.3 0.8
Lung FVC 0.5 2.4 2.4 1.6 -1.6
Neuroticism 4.2 10.2 19.6 1.0 -4.4
Chronotype (morning person) 0.0 0.1 0.1 0.2 0.4
Hair Pigment 0.0 1.0 1.8 1.4 0.3
Tanning 0.2 2.1 3.0 -1.1 1.7
Hand grip strength (left) 4.2 11.0 22.0 4.7 0.1
Number of treatments/medications taken 2.7 4.8 7.1 -2.7 -1.6
Average weekly spirits intake 2.5 3.1 5.6 0.9 -2.4
Sensitivity / hurt feelings 3.4 5.9 7.4 2.1 -2.7
Frequency of depressed mood in last 2 weeks 2.2 3.1 6.0 0.5 -2.4
Hearing difficulty/problems: Yes 1.1 1.7 2.4 1.0 -1.5
Relative age of first facial hair 1.3 2.8 2.9 1.6 1.7
Other serious medical condition/disability diagnosed by doctor 1.8 2.4 4.3 -2.1 -0.7
Ever used hormone-replacement therapy (HRT) 3.3 4.3 8.0 -0.7 -2.8
Ever had hysterectomy (womb removed) 1.0 1.1 1.4 1.2 -0.9
Systolic blood pressure, automated reading 0.3 0.8 1.3 0.5 1.2
Eye problems/disorders: Diabetes related eye disease 1.7 1.9 2.0 -1.4 1.4
Angina 1.7 2.3 3.5 -1.9 -1.0
Medication for hormone replacement therapy 0.7 0.7 0.9 -0.8 0.9
Vitamin and mineral supplements 1.5 2.0 3.8 -1.9 -0.4
Supplements: Zinc 0.4 0.5 0.9 0.2 0.9
Medication: Co-codamol 0.3 0.3 0.6 -0.8 0.3
Medication: Metformin 0.5 0.7 0.8 0.9 0.8
Diabetes (father) 1.3 1.6 1.7 1.3 1.2
Diabetes (mother) 0.7 0.9 1.1 -0.8 1.1
Severe depression (siblings) 0.8 0.9 1.1 -1.0 -0.9
Pack years adult smoking proportion 0.8 1.3 1.5 -1.2 -1.0
Impedance of leg (right) 0.4 1.8 2.3 -1.5 1.1
Leg fat-free mass (left) 0.1 0.5 1.0 1.0 -0.2
Trunk fat percentage 0.5 2.2 3.7 -1.9 0.8
Hand grip strength (right) 3.6 9.7 19.3 4.4 0.4
Townsend deprivation index at recruitment 2.9 4.1 5.6 -2.4 -1.6
Current tobacco smoking 1.5 2.5 4.5 -2.1 -0.7
Average weekly fortified wine intake 0.2 0.2 0.3 0.2 -0.6
Maternal smoking around birth 2.0 2.9 4.2 -2.1 1.2
Fed-up feelings 1.3 2.4 4.0 0.8 -2.0
Frequency of unenthusiasm / disinterest in last 2 weeks 0.5 0.7 1.4 0.1 -1.2
Relative age voice broke 0.2 0.3 0.5 0.1 -0.7
Taking other prescription medications 0.9 1.4 2.1 -0.9 -1.4
Age when periods started (menarche) 1.4 3.4 3.9 1.7 2.0
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.1 0.7 -1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.6 1.4 1.5 1.1 1.2
Tinnitus: Yes, but not now, but have in the past 1.5 1.6 2.6 -1.6 -0.7
Qualifications: CSEs or equivalent 0.6 0.8 1.6 1.3 -0.2
Serious illness, injury or assault to yourself 2.2 2.6 4.2 -2.0 -1.0
High blood pressure 0.1 0.4 0.7 -0.9 -0.1
Hayfever, allergic rhinitis or eczema 0.1 0.2 0.3 0.5 0.1
Multivitamins +/- minerals 0.1 0.1 0.2 0.3 0.4
Stomach or abdominal pain in last month 1.3 1.6 2.9 -1.7 0.4
Supplements: Glucosamine 0.4 0.6 1.1 1.0 0.2
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 1.7 -0.8 1.3
Medication: Atenolol 1.0 1.3 1.7 -1.3 -0.9
Medication: Levothyroxine sodium 1.2 2.0 3.2 -0.9 -1.8
Sitting height 0.1 0.8 1.5 0.2 1.2
Chronic bronchitis/emphysema (father) 1.9 2.3 4.1 -2.0 0.7
High blood pressure (mother) 1.9 2.7 4.3 -1.1 2.1
Body mass index (BMI) 0.1 0.6 1.0 1.0 -0.5
Impedance of leg (left) 0.7 3.5 3.9 -2.0 1.8
Leg predicted mass (left) 0.1 0.6 1.1 1.1 -0.2
Trunk fat mass 0.3 1.1 1.6 -1.3 0.8
Waist circumference 1.1 3.9 7.7 -2.8 -0.0
Number of incorrect matches in round 0.9 1.5 2.4 0.9 1.5
Past tobacco smoking 2.6 4.7 4.8 2.2 -2.2
Alcohol usually taken with meals 0.5 0.8 1.6 1.2 0.1
Nervous feelings 3.7 6.8 8.6 2.2 -2.9
Frequency of tenseness / restlessness in last 2 weeks 3.0 4.6 8.6 -0.8 -2.9
Hearing difficulty/problems with background noise 0.7 1.1 2.0 1.4 -0.5
Hair/balding pattern: Pattern 2 14.4 18.3 26.0 5.1 -3.3
Had menopause 0.4 0.5 0.6 -0.7 -0.8
Had other major operations 4.1 5.0 9.9 0.4 -3.1
Forced vital capacity (FVC) 0.3 1.3 2.6 1.6 -0.2
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.1 2.8 1.7 1.2
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 2.0 -0.3 1.4
Qualifications: None of the above 1.0 2.2 4.3 0.3 -2.1
Financial difficulties in last 2 years 3.0 4.1 6.2 1.4 -2.5
Mouth/teeth dental problems 1.6 2.4 4.8 0.2 2.2
Heart attack 3.9 5.0 10.0 -0.3 -3.2
Allergy 0.5 1.1 1.4 -1.2 -0.9
Pain all over the body in last month 2.5 2.7 4.8 -0.7 -2.2
Diabetes (self-reported) 0.2 0.3 0.6 0.2 -0.7
Hayfever/allergic rhinitis (self-reported) 1.8 2.3 2.6 -1.6 1.4
Medication: Ramipril 0.8 1.1 1.8 -0.5 1.4
Medication: Simvastatin 0.4 0.6 1.1 -1.1 0.0
Fluid intelligence score 0.2 0.5 0.9 -1.0 0.0
Illnesses of siblings 1.2 1.7 2.1 1.2 1.4
Neuroticism score 3.9 8.1 13.1 1.7 -3.6
Weight 0.0 0.1 0.1 0.3 0.4
Impedance of arm (right) 1.9 8.8 14.7 -3.8 1.7
Arm fat percentage (right) 0.1 0.5 0.8 -0.5 0.9
Trunk fat-free mass 0.2 1.2 2.2 1.5 0.4
Hip circumference 0.0 0.2 0.3 0.5 0.3
Time employed in main current job 0.1 0.1 0.3 -0.5 0.0
Alcohol intake versus 10 years previously 1.0 1.5 2.4 -1.6 0.7
Father’s age at death 0.3 0.4 0.8 -0.9 -0.2
Worrier / anxious feelings 2.9 5.5 8.6 1.5 -2.9
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 2.0 1.4 -1.2
Falls in the last year 0.3 0.4 0.6 -0.8 -0.4
Hair/balding pattern: Pattern 3 3.8 5.7 8.1 -2.9 1.8
Number of live births 0.5 0.7 1.2 1.1 -0.3
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 4.8 2.2 -0.1
Pulse rate 1.8 3.1 3.4 -1.8 1.7
Happiness 0.1 0.1 0.2 0.4 -0.2
Noisy workplace 0.0 0.0 0.1 0.3 -0.0
Qualifications: A levels/AS levels or equivalent 1.2 2.7 3.9 -2.0 1.2
Serious illness, injury or assault of a close relative in last 2 years 0.1 0.2 0.3 -0.5 -0.2
Mouth/teeth dental problems: Dentures 1.1 1.8 2.3 -1.1 -1.5
Asthma 1.1 2.1 2.3 1.4 1.5
Medication: Ibuprofen (e.g. Nurofen) 0.3 0.3 0.6 0.1 0.8
Medication: Cholesterol lowering 0.7 1.1 1.6 -1.3 -0.7
Depression (self-reported) 2.5 3.0 6.0 -0.0 -2.5
Medication: Lansoprazole 0.4 0.4 0.8 -0.3 -0.9
Prospective memory result 1.3 1.7 3.2 -0.3 1.8
Lung cancer (father) 0.1 0.2 0.3 -0.2 -0.6
Illnesses of mother 2.0 2.4 2.5 1.6 -1.6
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 4.9 2.2 -0.4
Pulse wave Arterial Stiffness index 2.0 2.3 2.9 -1.7 1.3
Impedance of arm (left) 2.2 10.3 18.4 -4.3 1.5
Arm fat mass (right) 0.1 0.3 0.5 -0.0 0.7
Trunk predicted mass 0.2 1.1 2.0 1.4 0.5
Standing height 0.4 3.5 5.2 -1.3 2.3
Length of working week for main job 0.4 0.5 0.8 -0.9 0.4
Exposure to tobacco smoke at home 0.3 0.3 0.6 0.1 0.8
Breastfed as a baby 0.4 0.5 0.6 -0.8 -0.6
Tense / ‘highly strung’ 1.7 2.8 4.5 1.1 -2.1
Seen doctor (GP) for nerves, anxiety, tension or depression 1.3 2.0 3.6 0.6 -1.9
Hair/balding pattern: Pattern 4 0.2 0.5 1.0 -0.1 -1.0
Birth weight of first child 0.2 0.3 0.4 -0.5 -0.6
Peak expiratory flow (PEF) 1.5 3.6 4.1 2.0 1.7
Pulse wave reflection index 0.4 0.4 0.7 -0.4 -0.9
Ever highly irritable/argumentative for 2 days 0.4 0.5 0.9 1.0 0.0
Loud music exposure frequency 1.5 1.6 2.8 -1.7 -0.7
Qualifications: O levels/GCSEs or equivalent 1.7 2.6 5.0 -0.5 2.2
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.1 -0.8 -1.1
Blood clot in the leg (DVT) 0.2 0.3 0.5 -0.2 -0.7
Medication: Paracetamol 0.9 1.6 2.8 -1.7 -0.6
Headache pain in last month 0.1 0.2 0.4 0.7 0.2
Medication for cholesterol, blood pressure or diabetes 1.4 2.4 4.6 2.1 0.5
Glaucoma (self-reported) 0.6 0.7 0.8 -0.7 -0.9
Gout (self-reported) 0.2 0.2 0.4 -0.6 -0.3
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 1.9 -0.2 -1.4
Medication: Amlodipine 0.7 0.9 1.8 -1.3 0.2
Medication: Ventolin 100micrograms inhaler 0.9 1.2 2.1 1.4 -0.5
Birth weight 0.3 0.7 1.2 0.3 -1.1
Chronic bronchitis/emphysema (mother) 2.5 2.9 5.3 -0.7 2.3
High blood pressure (siblings) 0.3 0.5 0.9 -0.9 0.2
Forced vital capacity (FVC), Best measure 0.5 2.0 3.8 2.0 -0.5
Body fat percentage 0.2 0.9 1.3 -1.2 0.6
Leg fat percentage (right) 0.1 0.2 0.3 0.5 -0.3
Arm fat-free mass (right) 0.2 1.3 2.5 1.6 0.3
Exposure to tobacco smoke outside home 0.5 0.7 0.9 -0.6 0.9
Comparative body size at age 10 1.0 2.8 4.1 1.3 -2.0
Number of full brothers 0.2 0.3 0.6 0.8 -0.1
Worry too long after embarrassment 1.9 3.2 5.8 0.8 -2.4
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 1.4 -0.4 -1.2
Wheeze or whistling in the chest in last year 0.7 1.3 2.5 -1.6 -0.1
Number of children fathered 0.5 0.6 1.1 0.1 -1.1
Reason for reducing amount of alcohol drunk: Health precaution 2.4 2.8 5.5 -0.3 2.3
Age at first live birth 0.6 1.0 2.0 -1.4 0.0
Pulse wave peak to peak time 1.5 1.7 2.5 1.6 -1.0
Health satisfaction 0.7 0.9 1.5 -1.2 -0.5
Shortness of breath walking on level ground 1.0 1.2 2.0 -0.6 1.4
Qualifications: College or University degree 1.1 3.4 3.5 -1.9 1.8
Eye problems/disorders: None of the above 1.8 2.0 2.5 1.2 1.6
Mouth/teeth dental problems: Loose teeth 1.2 1.4 2.6 -1.6 0.5
Emphysema/chronic bronchitis 1.1 1.2 2.4 -1.5 -0.1
Medication for pain relief, constipation, heartburn 0.4 0.7 1.0 1.0 0.7
Neck or shoulder pain in last month 0.5 0.7 1.4 0.2 -1.2
Medication: Blood pressure 0.7 1.3 1.5 -1.0 -1.2
Angina (self-reported) 1.0 1.3 2.5 -1.6 -0.4
Migraine (self-reported) 0.4 0.5 1.1 0.1 -1.0
Medication: Ibuprofen 0.5 0.6 1.0 -0.5 1.0
Medication: Allopurinol 0.0 0.1 0.1 -0.2 0.2
Medication: Omeprazole 0.2 0.2 0.3 -0.6 0.2
Medication: Seretide 50 evohaler 0.7 0.8 1.0 -1.0 -0.8
Mean time to correctly identify matches 0.8 1.6 3.1 -1.8 0.1
Heart disease (mother) 1.4 1.7 3.0 -1.7 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.7 0.8 1.4 1.2 -0.5
Whole body fat mass 0.1 0.3 0.3 -0.6 0.6
Leg fat mass (right) 0.0 0.1 0.1 0.4 0.1
Arm predicted mass (right) 0.2 0.8 1.6 1.3 -0.2
Pulse rate, automated reading 0.9 2.8 4.0 -2.0 1.3
Alcohol intake frequency. 0.5 1.2 2.4 -1.6 0.3
Comparative height size at age 10 0.3 1.7 1.8 -1.3 1.3
Number of full sisters 0.2 0.2 0.3 -0.4 0.5
Suffer from ‘nerves’ 1.5 2.4 4.7 -0.3 -2.2
Overall health rating 2.9 6.3 7.1 -2.4 -2.7
Chest pain or discomfort 2.5 3.6 3.9 -1.8 -2.0
Had major operations 0.2 0.2 0.4 -0.3 -0.6
Age at last live birth 1.1 1.6 3.2 -1.8 -0.2
Family relationship satisfaction 1.2 1.5 2.5 -1.6 -0.7
Leg pain on walking 1.0 1.3 2.6 -1.6 0.0
Qualifications: NVQ or HND or HNC or equivalent 1.2 1.4 2.4 -0.7 -1.6
Commuting to job workplace: Car/motor vehicle 1.6 1.8 1.9 1.3 1.4
Illness, injury, bereavement, stress in last 2 years 2.4 3.0 5.2 0.9 2.3
Medication: Aspirin 0.3 0.4 0.6 -0.4 -0.8
Supplements: Vitamin C 0.8 0.9 1.6 1.3 0.5
Knee pain experienced in last month 0.7 1.1 1.5 0.9 1.2
Hypertension (Self-reported) 0.2 0.6 1.0 -1.0 -0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.4 1.7 3.3 0.3 1.8
Illnesses of father: Heart disease 1.3 1.8 3.3 -1.8 -0.6
Illnesses of siblings: Diabetes 1.9 2.3 3.4 1.1 -1.8
Smoking status: Previous 2.8 4.2 4.8 -1.9 2.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.6 -0.1 1.3
Whole body fat-free mass 0.1 0.8 1.6 1.3 0.2
Leg fat-free mass (right) 0.1 0.4 0.7 0.8 0.1
Arm fat percentage (left) 0.1 0.5 0.7 -0.9 0.5
Average weekly red wine intake 2.3 3.5 4.7 2.2 -1.5
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.6 -0.8 -0.4
Mood swings 4.7 8.5 12.2 2.2 -3.5
Loneliness, isolation 2.0 2.8 3.0 -1.6 -1.7
Long-standing illness, disability or infirmity 2.6 3.9 7.6 -2.8 -0.5
Ever had bowel cancer screening 0.6 0.7 0.8 -0.8 0.9
Diabetes diagnosed by doctor 0.0 0.0 0.0 0.1 0.1
Ever had stillbirth, spontaneous miscarriage or termination 3.7 3.9 5.8 1.4 -2.4
Friendships satisfaction 0.5 0.6 1.2 -1.1 0.4
Qualifications: nursing, teaching 1.0 1.5 2.9 -1.7 -0.3
Commuting to job workplace: Walk 1.6 1.7 3.4 0.3 -1.8
Eye problems/disorders: Cataract 1.1 1.3 1.9 -1.4 -0.8
Mouth/teeth dental problems: Mouth ulcers 1.3 2.1 2.8 1.7 -1.2
Medication for cholesterol 0.6 0.9 1.8 1.3 0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.2 1.4 2.3 -1.5 -0.7
Back pain experienced in last month 0.1 0.2 0.2 0.5 -0.3
Mineral and other dietary supplements 0.4 0.6 0.6 0.7 -0.8
Breast cancer (self-reported) 0.7 0.8 1.2 0.6 1.1
Asthma (self-reported) 1.1 2.1 2.4 1.4 1.6
Osteoporosis (self-reported) 1.9 2.3 3.3 -1.2 -1.8
Osteoarthritis (self-reported) 0.2 0.2 0.3 -0.6 0.4
Medication: Aspirin 0.4 0.5 0.8 -0.9 -0.4
Medication: Gliclazide 0.8 0.9 1.1 0.8 -1.0
Illnesses of father: None of the above (group 1) 0.1 0.2 0.3 -0.5 -0.3
Smoking status: Current 1.2 1.9 3.4 -1.9 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.1 0.6 -1.0
Whole body water mass 0.1 0.7 1.3 1.2 0.3
Leg predicted mass (right) 0.1 0.4 0.7 0.8 0.2
Arm fat mass (left) 0.0 0.1 0.2 -0.1 0.5
Number of self-reported non-cancer illnesses 0.7 1.3 1.3 -1.2 -1.1
Average weekly champagne plus white wine intake 2.1 2.9 3.8 -1.4 2.0
Miserableness 1.4 2.3 4.6 0.3 -2.1
Guilty feelings 0.2 0.3 0.7 -0.0 0.8
Wears glasses or contact lenses 0.7 0.8 1.6 -0.3 -1.3
Ever taken oral contraceptive pill 0.3 0.3 0.5 -0.3 0.7
Hearing aid user 0.5 0.5 0.6 -0.7 0.8
Mother’s age at death 0.5 0.7 1.3 -0.1 1.1
Financial situation satisfaction 0.4 0.5 0.9 0.3 -0.9
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.1 1.1 -0.2
Commuting to job workplace: Public transport 1.3 1.6 3.1 -0.3 1.8
Eye problems/disorders: Glaucoma 1.9 2.2 4.2 -2.1 -0.4
Medication: Blood pressure 0.4 0.8 1.6 -1.3 0.3
Pain type(s) experienced in last month: Hip pain 0.2 0.2 0.4 -0.1 -0.6
Supplements: Fish oil (including cod liver oil) 3.3 4.3 6.9 -1.3 2.6
High cholesterol (Self-reported) 0.8 1.4 1.8 -1.4 -0.9
Medication: Bendroflumethiazide 1.0 1.5 3.0 -1.7 -0.1
Medication: Paracetamol 1.2 1.9 3.1 -1.8 -0.8
Medication: Lisinopril 0.3 0.4 0.7 -0.1 -0.8
Medication: Atorvastatin 0.6 0.7 0.9 -0.8 -0.9
Illnesses of father: High blood pressure 0.3 0.3 0.6 0.1 0.8
Alcohol drinker status: Never 1.5 1.8 2.8 1.7 -0.9
Ever smoked 1.3 2.3 3.4 -1.1 1.9
Basal metabolic rate 0.1 0.5 0.9 1.0 0.3
Leg fat percentage (left) 0.0 0.0 0.0 0.1 0.1
Arm fat-free mass (left) 0.2 1.1 2.1 1.5 0.2
Number of operations (self-reported) 3.9 5.8 11.6 0.3 -3.4
Average weekly beer plus cider intake 1.1 1.6 2.1 -1.0 1.5
Irritability 2.8 4.7 8.8 3.0 -0.8
Risk taking 1.3 1.9 3.7 1.9 0.3
Ever had prostate specific antigen (PSA) test 0.5 0.6 0.7 -0.7 0.9
Fractured/broken bones in last 5 years 4.0 5.2 8.5 -1.4 -2.9
Age started oral contraceptive pill 0.1 0.1 0.3 -0.5 -0.1
Diastolic blood pressure, automated reading 0.1 0.2 0.4 -0.3 0.6
Ever depressed for a whole week 1.2 1.5 1.9 -1.0 1.4
Unable to work because of sickness or disability 0.9 1.2 1.5 -0.9 -1.2
Commuting to job workplace: Cycle 0.7 0.9 1.8 0.1 1.3
Myopia 0.5 0.7 1.4 0.1 -1.2
Vascular/heart problems diagnosed by doctor 0.5 1.4 2.7 1.6 0.4
Cholesterol lowering medication 0.7 1.1 2.1 -1.4 -0.1
Medication: Omeprazole (e.g. Zanprol) 0.4 0.5 0.9 -0.9 0.1
Pain experienced in last month 0.8 1.3 2.1 -0.8 1.4
Supplements: Calcium 2.0 2.2 3.4 1.0 -1.9
Basal cell carcinoma (self-reported) 0.2 0.2 0.3 0.5 0.5
Heart attack/myocardial infarction (self-reported) 4.1 5.3 10.6 -0.3 -3.2
Deep venous thrombosis (DVT) (self-reported) 0.2 0.2 0.4 -0.2 -0.6
Heart disease (siblings) 2.7 3.3 6.6 -0.2 -2.6
Alcohol drinker status: Previous 0.2 0.2 0.4 -0.6 -0.2
Pack years of smoking 0.7 1.1 1.2 -1.1 -1.0
Impedance of whole body 1.7 8.4 13.2 -3.6 1.9
Leg fat mass (left) 0.0 0.0 0.1 0.2 0.2
Arm predicted mass (left) 0.2 1.1 2.1 1.5 0.4