Best TWAS P=2.39e-11 · Best GWAS P=2.63e-10 conditioned to 7.02e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | STOML1 | 0.14 | 0.13 | lasso | 6 | 0.13 | 5.4e-16 | -5.7 | -5.7 | 1.0e-08 | 0.16 | 0.18 | 0.82 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | STOML1 | 0.12 | 0.04 | lasso | 3 | 0.03 | 1.2e-03 | -6.2 | -5.8 | 5.8e-09 | 0.15 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Brain Cerebellum | STOML1 | 0.20 | 0.19 | enet | 9 | 0.16 | 1.8e-05 | -4.7 | -5.7 | 1.5e-08 | 0.18 | 0.02 | 0.97 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | STOML1 | 0.21 | -0.01 | lasso | 4 | -0.01 | 5.4e-01 | -6.0 | -5.7 | 1.5e-08 | 0.20 | 0.03 | 0.32 | FALSE |
| 5 | GTEx | Colon Transverse | CTD-2323K18.1 | 0.13 | 0.04 | lasso | 11 | 0.05 | 1.8e-03 | -4.7 | -5.2 | 2.6e-07 | 0.10 | 0.02 | 0.84 | FALSE |
| 6 | GTEx | Esophagus Mucosa | STOML1 | 0.10 | 0.07 | lasso | 3 | 0.06 | 5.0e-05 | -6.2 | -5.9 | 3.4e-09 | 0.16 | 0.02 | 0.98 | FALSE |
| 7 | GTEx | Esophagus Muscularis | STOML1 | 0.15 | 0.16 | lasso | 3 | 0.17 | 2.1e-10 | -5.7 | -5.5 | 3.9e-08 | 0.16 | 0.07 | 0.93 | FALSE |
| 8 | GTEx | Heart Left Ventricle | STOML1 | 0.21 | 0.06 | lasso | 4 | 0.06 | 4.8e-04 | -5.7 | -5.4 | 8.3e-08 | 0.17 | 0.03 | 0.94 | FALSE |
| 9 | GTEx | Lung | STOML1 | 0.14 | 0.10 | lasso | 4 | 0.12 | 1.5e-09 | -5.7 | -5.4 | 8.5e-08 | 0.17 | 0.04 | 0.96 | FALSE |
| 10 | GTEx | Nerve Tibial | STOML1 | 0.18 | 0.15 | enet | 27 | 0.15 | 1.3e-10 | -6.2 | -5.9 | 2.8e-09 | 0.22 | 0.01 | 0.99 | FALSE |
| 11 | GTEx | Testis | MAN2C1 | 0.25 | 0.26 | lasso | 4 | 0.28 | 1.1e-12 | -4.7 | -5.5 | 4.7e-08 | 0.08 | 0.02 | 0.96 | FALSE |
| 12 | GTEx | Whole Blood | STOML1 | 0.14 | 0.07 | lasso | 5 | 0.06 | 5.8e-06 | -5.6 | -5.5 | 4.7e-08 | 0.19 | 0.06 | 0.94 | FALSE |
| 13 | YFS | Blood | PML | 0.05 | 0.05 | lasso | 6 | 0.05 | 3.8e-16 | -6.0 | -5.7 | 9.9e-09 | 0.21 | 0.03 | 0.97 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | STOML1 | 0.03 | 0.02 | blup | 62 | 0.02 | 1.9e-04 | -5.2 | -6.2 | 6.6e-10 | 0.26 | 0.03 | 0.97 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SNUPN | 0.11 | 0.06 | blup | 38 | 0.06 | 3.9e-04 | -4.6 | -5.7 | 1.0e-08 | 0.11 | 0.00 | 0.82 | TRUE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | STOML1 | 0.03 | 0.03 | lasso | 4 | 0.03 | 3.4e-04 | -6.0 | -6.0 | 1.7e-09 | 0.20 | 0.02 | 0.98 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | STOML1 | 0.02 | 0.01 | blup | 62 | 0.00 | 2.4e-01 | -5.7 | -6.7 | 2.4e-11 | 0.28 | 0.02 | 0.73 | TRUE |
| 18 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | MAN2C1 | 0.08 | 0.02 | blup | 14 | 0.04 | 1.3e-02 | -4.1 | -5.2 | 2.4e-07 | 0.10 | 0.00 | 0.04 | FALSE |
| 19 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | STOML1 | 0.12 | 0.08 | lasso | 6 | 0.08 | 2.4e-04 | -5.7 | -5.2 | 2.2e-07 | 0.10 | 0.02 | 0.64 | FALSE |
| 20 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MAN2C1 | 0.07 | 0.04 | blup | 15 | 0.05 | 6.6e-06 | 3.5 | -5.3 | 1.3e-07 | 0.05 | 0.00 | 0.12 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | STOML1 | 0.07 | 0.05 | lasso | 7 | 0.04 | 1.9e-05 | -6.0 | -6.0 | 2.4e-09 | 0.18 | 0.02 | 0.98 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | MAN2C1 | 0.09 | 0.05 | blup | 13 | 0.06 | 3.1e-06 | 3.5 | -5.7 | 1.0e-08 | 0.06 | 0.00 | 0.15 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | STOML1 | 0.09 | 0.09 | blup | 62 | 0.10 | 3.7e-10 | -5.2 | -6.5 | 1.0e-10 | 0.32 | 0.03 | 0.97 | FALSE |