Best TWAS P=3.72e-14 · Best GWAS P=1.41e-08 conditioned to 0.0307
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Tibial | AC103965.1 | 0.27 | 0.26 | enet | 31 | 0.30 | 1.8e-23 | 4.9 | -5.9 | 4.7e-09 | 0.56 | 0.50 | 0.49 | FALSE |
2 | GTEx | Artery Tibial | CSPG4P11 | 0.16 | 0.24 | lasso | 4 | 0.23 | 3.0e-18 | 4.9 | -5.1 | 2.9e-07 | 0.54 | 0.44 | 0.56 | FALSE |
3 | GTEx | Brain Cerebellar Hemisphere | UBE2Q2P1 | 0.18 | 0.08 | enet | 18 | 0.12 | 4.2e-04 | 2.6 | 5.4 | 7.3e-08 | -0.45 | 0.16 | 0.24 | FALSE |
4 | GTEx | Brain Cortex | AC103965.1 | 0.17 | 0.19 | lasso | 3 | 0.16 | 4.3e-05 | 5.0 | -5.3 | 1.2e-07 | 0.46 | 0.19 | 0.49 | FALSE |
5 | GTEx | Brain Cortex | RP11-182J1.14 | 0.24 | 0.03 | enet | 14 | 0.16 | 3.2e-05 | 4.6 | 7.6 | 3.7e-14 | -0.46 | 0.07 | 0.25 | TRUE |
6 | GTEx | Breast Mammary Tissue (Male) | AC103965.1 | 0.24 | 0.14 | lasso | 4 | 0.11 | 1.4e-03 | 5.0 | -5.7 | 1.6e-08 | 0.53 | 0.11 | 0.32 | FALSE |
7 | GTEx | Cells Transformed fibroblasts | AC103965.1 | 0.15 | 0.09 | lasso | 7 | 0.11 | 1.3e-08 | 4.9 | -5.2 | 1.7e-07 | 0.49 | 0.45 | 0.54 | FALSE |
8 | GTEx | Colon Sigmoid | RN7SL417P | 0.17 | 0.06 | lasso | 4 | 0.12 | 6.1e-05 | 4.8 | 5.4 | 8.4e-08 | -0.46 | 0.24 | 0.20 | FALSE |
9 | GTEx | Colon Sigmoid | RP11-182J1.14 | 0.31 | 0.29 | lasso | 9 | 0.30 | 2.7e-11 | 4.6 | 5.2 | 2.5e-07 | -0.46 | 0.59 | 0.41 | FALSE |
10 | GTEx | Esophagus Mucosa | UBE2Q2P1 | 0.38 | 0.26 | enet | 37 | 0.28 | 3.7e-19 | 4.9 | 7.4 | 1.5e-13 | -0.38 | 0.36 | 0.64 | FALSE |
11 | GTEx | Esophagus Mucosa | AC103965.1 | 0.20 | 0.19 | enet | 47 | 0.16 | 8.4e-11 | 4.9 | -5.3 | 1.4e-07 | 0.38 | 0.42 | 0.58 | FALSE |
12 | GTEx | Nerve Tibial | UBE2Q2P1 | 0.13 | 0.01 | enet | 37 | 0.04 | 1.3e-03 | 4.9 | 5.6 | 2.5e-08 | -0.30 | 0.10 | 0.39 | FALSE |
13 | GTEx | Nerve Tibial | AC103965.1 | 0.20 | 0.22 | enet | 17 | 0.27 | 5.1e-19 | 4.9 | -5.7 | 1.3e-08 | 0.58 | 0.50 | 0.50 | FALSE |
14 | GTEx | Ovary | RP11-182J1.14 | 0.19 | 0.04 | enet | 17 | 0.17 | 7.3e-05 | -2.9 | 5.7 | 1.0e-08 | -0.12 | 0.05 | 0.09 | FALSE |
15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GOLGA6L5 | 0.04 | 0.04 | enet | 5 | 0.05 | 4.6e-11 | -3.2 | -5.3 | 1.0e-07 | 0.44 | 0.04 | 0.78 | FALSE |
16 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZSCAN2 | 0.11 | 0.00 | blup | 46 | 0.03 | 1.2e-04 | 4.1 | 6.6 | 4.2e-11 | -0.25 | 0.01 | 0.26 | TRUE |
17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GOLGA6L5 | 0.04 | 0.01 | blup | 7 | 0.03 | 4.9e-04 | 4.9 | -5.4 | 7.5e-08 | 0.44 | 0.00 | 0.88 | FALSE |
18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | UBE2Q2P1 | 0.07 | 0.04 | blup | 22 | 0.06 | 1.8e-07 | 4.9 | 5.2 | 1.7e-07 | -0.35 | 0.00 | 0.99 | FALSE |
19 | The Cancer Genome Atlas | Lung Adenocarcinoma | GOLGA6L5 | 0.05 | 0.04 | blup | 7 | 0.05 | 5.1e-07 | -4.2 | -5.2 | 1.6e-07 | 0.42 | 0.02 | 0.59 | FALSE |
20 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | UBE2Q2P1 | 0.03 | 0.03 | lasso | 3 | 0.02 | 9.2e-04 | 4.9 | 5.3 | 1.5e-07 | -0.43 | 0.00 | 0.85 | FALSE |
21 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | GOLGA6L5 | 0.10 | 0.04 | enet | 2 | 0.10 | 9.9e-05 | -4.2 | -5.4 | 6.2e-08 | 0.41 | 0.00 | 0.53 | FALSE |
22 | The Cancer Genome Atlas | Soft Tissue Sarcoma | GOLGA6L5 | 0.09 | 0.08 | enet | 4 | 0.09 | 5.2e-06 | -4.2 | -5.1 | 2.9e-07 | 0.45 | 0.01 | 0.36 | FALSE |
23 | The Cancer Genome Atlas | Thyroid Carcinoma | GOLGA6L5 | 0.15 | 0.16 | lasso | 3 | 0.19 | 1.8e-18 | -4.2 | -5.2 | 2.3e-07 | 0.38 | 0.03 | 0.84 | FALSE |