Best TWAS P=5.48e-12 · Best GWAS P=1.73e-11 conditioned to 0.42
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | RBL2 | 0.22 | 0.24 | enet | 15 | 0.26 | 1.8e-31 | -4.3 | 5.7 | 1.2e-08 | -0.87 | 0.84 | 0.16 | FALSE |
| 2 | GTEx | Brain Cortex | RBL2 | 0.51 | 0.45 | enet | 12 | 0.46 | 3.5e-14 | -4.6 | 5.2 | 1.8e-07 | -0.81 | 0.17 | 0.83 | FALSE |
| 3 | GTEx | Colon Sigmoid | RBL2 | 0.38 | 0.37 | lasso | 12 | 0.29 | 8.4e-11 | -4.4 | 5.1 | 2.7e-07 | -0.80 | 0.71 | 0.29 | FALSE |
| 4 | GTEx | Esophagus Mucosa | RBL2 | 0.36 | 0.36 | enet | 37 | 0.37 | 2.9e-26 | -4.4 | 5.1 | 3.1e-07 | -0.79 | 0.99 | 0.01 | FALSE |
| 5 | GTEx | Muscle Skeletal | RBL2 | 0.11 | 0.00 | lasso | 5 | 0.00 | 2.9e-01 | -6.7 | 5.8 | 7.6e-09 | -0.90 | 0.01 | 0.97 | FALSE |
| 6 | GTEx | Pancreas | RBL2 | 0.36 | 0.36 | enet | 26 | 0.36 | 5.9e-16 | -4.5 | 5.4 | 5.1e-08 | -0.79 | 0.92 | 0.08 | FALSE |
| 7 | YFS | Blood | AKTIP | 0.19 | 0.27 | lasso | 13 | 0.30 | 3.3e-99 | -6.6 | -6.2 | 5.5e-10 | 0.92 | 0.00 | 1.00 | FALSE |
| 8 | The Cancer Genome Atlas | Esophageal Carcinoma | RBL2 | 0.08 | 0.04 | lasso | 3 | 0.03 | 4.4e-02 | -6.6 | -5.3 | 1.1e-07 | 0.84 | 0.01 | 0.76 | FALSE |
| 9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RBL2 | 0.03 | 0.06 | enet | 5 | 0.05 | 8.2e-07 | -4.6 | 5.2 | 1.8e-07 | -0.82 | 0.29 | 0.71 | FALSE |
| 10 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | RBL2 | 0.11 | 0.08 | blup | 44 | 0.06 | 1.5e-03 | -6.7 | 6.9 | 5.5e-12 | -0.93 | 0.00 | 0.87 | TRUE |