Best TWAS P=2.64e-21 · Best GWAS P=1.53e-14 conditioned to 0.132
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | HSD17B1P1 | 0.09 | 0.06 | lasso | 3 | 0.05 | 1.7e-03 | -7.3 | 6.5 | 8.7e-11 | 0.18 | 0.16 | 0.32 | FALSE |
| 2 | GTEx | Artery Coronary | RP11-400F19.6 | 0.15 | 0.02 | lasso | 3 | 0.03 | 4.1e-02 | 7.0 | -6.8 | 7.3e-12 | -0.12 | 0.10 | 0.07 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-400F19.6 | 0.07 | 0.01 | lasso | 5 | 0.01 | 3.0e-02 | 5.7 | -5.8 | 6.1e-09 | -0.34 | 0.53 | 0.06 | TRUE |
| 4 | GTEx | Breast Mammary Tissue | HSD17B1P1 | 0.09 | 0.03 | lasso | 4 | 0.02 | 2.6e-02 | -7.3 | 5.6 | 2.7e-08 | 0.14 | 0.21 | 0.26 | FALSE |
| 5 | GTEx | Breast Mammary Tissue (Male) | HSD17B1P1 | 0.09 | 0.14 | lasso | 1 | 0.07 | 1.2e-02 | -7.3 | 7.3 | 2.1e-13 | 0.24 | 0.03 | 0.08 | FALSE |
| 6 | GTEx | Cells EBV-transformed lymphocytes | HSD17B1 | 0.14 | 0.13 | enet | 8 | 0.12 | 8.9e-05 | -7.3 | 5.9 | 4.2e-09 | 0.14 | 0.23 | 0.32 | FALSE |
| 7 | GTEx | Esophagus Mucosa | BECN1 | 0.24 | 0.08 | lasso | 4 | 0.05 | 5.1e-04 | 5.7 | 5.8 | 8.0e-09 | 0.25 | 0.28 | 0.18 | FALSE |
| 8 | GTEx | Esophagus Muscularis | NAGLU | 0.29 | 0.09 | lasso | 5 | 0.07 | 6.2e-05 | 5.7 | -5.3 | 8.8e-08 | -0.31 | 0.72 | 0.03 | FALSE |
| 9 | GTEx | Muscle Skeletal | TUBG2 | 0.12 | 0.09 | lasso | 8 | 0.10 | 1.1e-09 | 5.0 | -5.5 | 2.8e-08 | -0.33 | 0.99 | 0.00 | FALSE |
| 10 | GTEx | Muscle Skeletal | HSD17B1P1 | 0.05 | 0.03 | lasso | 3 | 0.02 | 2.0e-03 | -7.3 | 7.3 | 2.6e-13 | 0.19 | 0.15 | 0.48 | FALSE |
| 11 | GTEx | Nerve Tibial | RP11-400F19.8 | 0.10 | 0.03 | lasso | 3 | 0.02 | 8.2e-03 | 5.7 | -5.5 | 4.9e-08 | -0.30 | 0.13 | 0.34 | FALSE |
| 12 | GTEx | Prostate | FKBP10 | 0.43 | 0.08 | enet | 14 | 0.08 | 6.0e-03 | 6.0 | -6.8 | 1.3e-11 | -0.20 | 0.08 | 0.08 | TRUE |
| 13 | GTEx | Skin Not Sun Exposed Suprapubic | TUBG2 | 0.15 | 0.13 | lasso | 5 | 0.12 | 4.0e-07 | 5.7 | -5.2 | 2.7e-07 | -0.28 | 0.98 | 0.00 | FALSE |
| 14 | GTEx | Spleen | CNTNAP1 | 0.20 | 0.16 | enet | 12 | 0.16 | 7.2e-05 | -7.0 | -5.5 | 4.8e-08 | -0.15 | 0.16 | 0.08 | FALSE |
| 15 | GTEx | Spleen | CTD-3193K9.3 | 0.16 | 0.10 | enet | 24 | 0.14 | 1.6e-04 | -7.0 | -6.6 | 5.0e-11 | -0.26 | 0.19 | 0.09 | FALSE |
| 16 | GTEx | Thyroid | NAGLU | 0.23 | 0.10 | enet | 33 | 0.09 | 1.0e-07 | 3.8 | -5.2 | 1.5e-07 | -0.11 | 0.98 | 0.00 | FALSE |
| 17 | GTEx | Thyroid | STAT5A | 0.09 | 0.03 | lasso | 4 | 0.04 | 3.4e-04 | 7.6 | -6.3 | 3.8e-10 | -0.81 | 0.02 | 0.95 | FALSE |
| 18 | GTEx | Thyroid | LEPREL4 | 0.09 | 0.03 | lasso | 4 | 0.04 | 3.0e-04 | -3.6 | 5.7 | 1.2e-08 | 0.07 | 0.87 | 0.00 | FALSE |
| 19 | GTEx | Whole Blood | HSD17B1P1 | 0.04 | 0.02 | enet | 16 | 0.03 | 1.0e-03 | -7.0 | 9.5 | 2.6e-21 | 0.49 | 0.06 | 0.65 | TRUE |
| 20 | NTR | Blood | IFI35 | 0.02 | 0.00 | bslmm | 253 | 0.01 | 4.5e-04 | -7.0 | -5.9 | 4.6e-09 | -0.11 | 0.01 | 0.80 | FALSE |
| 21 | YFS | Blood | ACLY | 0.05 | 0.05 | lasso | 5 | 0.05 | 4.4e-15 | -5.2 | 5.6 | 2.6e-08 | 0.07 | 1.00 | 0.00 | FALSE |
| 22 | YFS | Blood | IFI35 | 0.25 | 0.00 | bslmm | 246 | 0.09 | 2.2e-29 | -6.3 | -6.0 | 1.6e-09 | -0.14 | 0.02 | 0.21 | TRUE |
| 23 | The Cancer Genome Atlas | Colon Adenocarcinoma | NT5C3L | 0.18 | 0.21 | blup | 17 | 0.23 | 2.8e-13 | -3.6 | -5.3 | 1.4e-07 | -0.04 | 0.02 | 0.49 | FALSE |
| 24 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | TUBG2 | 0.09 | 0.01 | blup | 29 | 0.03 | 1.9e-02 | -7.0 | 5.1 | 2.8e-07 | 0.06 | 0.01 | 0.50 | FALSE |
| 25 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC100190938 | 0.03 | 0.00 | enet | 4 | 0.01 | 8.1e-02 | 7.2 | -6.5 | 7.6e-11 | -0.15 | 0.00 | 0.67 | FALSE |