TWAS hub - FKBP10

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0930	0.0360	9.6e-05	0.035	NA	0.030	NA	0.044	7.4e-04	NA	1.5e-03	NA	1.6e-04
2	GTEx	Artery Aorta	0.2370	0.0680	1.7e-06	0.130	NA	0.093	NA	0.124	1.3e-07	NA	8.7e-06	NA	2.5e-07
3	GTEx	Artery Coronary	0.1330	0.0590	4.4e-03	0.084	NA	0.014	NA	0.056	8.7e-04	NA	1.1e-01	NA	5.8e-03
4	GTEx	Artery Tibial	0.0640	0.0265	1.4e-03	0.035	NA	0.042	NA	0.032	9.6e-04	NA	3.1e-04	NA	1.4e-03
5	GTEx	Brain Nucleus accumbens basal ganglia	0.2520	0.0850	6.8e-04	0.113	NA	0.027	NA	0.069	6.2e-04	NA	6.3e-02	NA	6.5e-03
6	GTEx	Cells Transformed fibroblasts	0.2330	0.0550	7.7e-11	0.201	NA	0.141	NA	0.194	5.1e-15	NA	9.4e-11	NA	1.8e-14
7	GTEx	Esophagus Gastroesophageal Junction	0.1150	0.0520	5.6e-03	0.085	NA	-0.008	NA	0.042	5.6e-04	NA	9.3e-01	NA	1.2e-02
8	GTEx	Esophagus Muscularis	0.1990	0.0580	6.6e-07	0.132	NA	0.102	NA	0.114	2.2e-08	NA	9.1e-07	NA	2.1e-07
9	GTEx	Lung	0.0748	0.0305	1.8e-03	0.031	NA	0.011	NA	0.018	2.0e-03	NA	4.6e-02	NA	1.4e-02
10	GTEx	Muscle Skeletal	0.0505	0.0210	8.8e-04	0.013	NA	0.003	NA	0.012	1.7e-02	NA	1.4e-01	NA	1.9e-02
11	GTEx	Nerve Tibial	0.2067	0.0495	1.2e-12	0.242	NA	0.245	NA	0.239	3.8e-17	NA	2.3e-17	NA	5.9e-17
12	GTEx	Prostate	0.4290	0.1830	5.1e-03	0.080	NA	0.076	NA	0.065	4.9e-03	NA	5.9e-03	NA	1.0e-02
13	GTEx	Skin Sun Exposed Lower leg	0.0740	0.0290	4.4e-04	0.027	NA	0.012	NA	0.021	2.5e-03	NA	3.5e-02	NA	6.9e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Impedance of leg (left)	8.6	41.9	49.7	-6.6	-6.2	-6.8	-5.2	-6.2	-6.6	-7.0	-7.0	-7.0	-6.9	-7.0	-4.1	-7.0
Impedance of leg (right)	8.0	38.9	47.4	-6.4	-5.9	-6.5	-5.0	-6.0	-6.2	-6.9	-6.7	-6.7	-6.8	-6.7	-3.6	-6.6
Osteoarthritis (self-reported)	6.2	8.0	10.7	2.3	2.9	2.8	2.9	3.1	2.7	3.3	3.3	3.2	2.8	3.0	1.9	2.2
Eye problems/disorders: Cataract	6.0	7.0	9.9	-2.6	-2.7	-2.6	-2.1	-3.1	-2.3	-3.0	-2.8	-2.9	-2.7	-2.9	-1.5	-2.6
Friendships satisfaction	4.9	6.0	8.2	1.5	2.7	2.8	2.3	2.5	2.9	2.6	2.8	2.8	1.2	2.5	2.5	2.1
Eye problems/disorders: Diabetes related eye disease	4.8	5.3	6.7	2.3	2.3	2.3	1.9	2.5	2.2	2.4	2.4	2.4	2.3	2.4	1.7	2.6
Impedance of whole body	4.6	23.6	30.4	-5.5	-4.4	-5.1	-3.6	-4.4	-4.8	-5.2	-5.1	-5.1	-5.5	-5.3	-3.1	-5.3
Hearing difficulty/problems with background noise	4.2	6.7	12.2	1.1	3.0	3.0	2.6	2.7	3.2	2.6	2.8	2.8	0.9	2.5	3.5	1.4
Diabetes (father)	4.0	4.9	6.5	-1.7	-2.2	-2.5	-2.1	-2.1	-2.6	-2.4	-2.5	-2.5	-1.8	-2.4	-2.3	-1.5
Eye problems/disorders: None of the above	3.8	4.4	6.9	1.7	2.0	2.1	1.1	2.5	2.0	2.6	2.5	2.6	2.4	2.4	0.8	1.8
Medication: Lisinopril	3.7	4.7	7.7	-2.8	-1.9	-2.4	-1.5	-2.2	-2.0	-2.2	-2.1	-2.1	-2.5	-2.6	-1.3	-2.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	3.2	3.7	6.5	-1.2	-2.3	-2.3	-1.5	-1.9	-2.5	-2.0	-2.1	-2.1	-1.0	-2.0	-2.1	-1.5
Waist Hip Ratio (WHR)	2.9	13.2	45.8	-1.2	-3.5	-3.8	-4.2	-2.9	-4.4	-3.3	-3.6	-3.8	-1.1	-3.1	-6.8	-1.9
Medication: Bendroflumethiazide	2.8	4.2	10.3	-2.3	-2.0	-2.1	-1.5	-1.8	-2.1	-1.8	-1.8	-1.8	-1.8	-2.1	-3.2	-1.8
Mean Putamen Volume	2.7	3.1	4.8	-1.8	-1.7	-1.7	-1.0	-1.9	-1.6	-2.0	-1.9	-1.9	-2.2	-1.9	-1.1	-1.9
Noisy workplace	2.7	3.4	6.3	1.1	2.1	2.4	0.4	1.9	2.5	2.2	2.3	2.2	0.9	2.0	1.4	1.0
Alzheimer’s Disease (in mother)	2.6	3.0	4.3	-2.1	-1.9	-1.8	-1.4	-1.5	-1.8	-1.6	-1.7	-1.8	-1.7	-1.9	-1.9	-1.3
Breastfed as a baby	2.6	3.3	5.3	-2.0	-1.6	-2.2	-1.7	-1.6	-2.3	-1.7	-1.8	-1.8	-1.9	-2.1	-1.0	-1.5
Leg fat percentage (right)	2.5	8.9	15.3	-3.0	-2.9	-2.9	-2.0	-3.5	-2.6	-3.0	-2.9	-3.0	-3.4	-3.1	-2.2	-3.9
Forced expiratory volume in 1-second (FEV1)	2.4	8.2	11.2	2.4	3.3	2.9	1.4	3.3	3.0	3.2	3.3	3.4	2.9	3.0	0.8	3.0
Suffer from ‘nerves’	2.4	3.8	5.6	2.1	2.4	2.4	1.3	2.3	2.2	2.0	2.1	1.9	1.4	2.2	1.5	1.4
Tinnitus: Yes, now most or all of the time	2.4	2.8	4.5	0.9	2.0	1.9	2.1	1.7	1.9	1.7	1.8	1.7	0.5	1.6	1.8	1.4
Leg fat percentage (left)	2.4	8.8	16.1	-3.0	-2.8	-2.8	-2.0	-3.4	-2.6	-2.9	-2.9	-2.9	-3.3	-3.0	-2.5	-4.0
Unable to work because of sickness or disability	2.4	3.2	4.8	2.1	1.6	1.8	0.6	1.7	1.6	2.0	2.0	2.1	2.2	2.0	0.4	2.1
Hypothyroidism/myxoedema (self-reported)	2.3	4.5	6.4	2.0	1.9	2.2	2.0	1.9	2.5	2.2	2.3	2.3	2.0	2.2	1.0	2.5
Leg predicted mass (right)	2.3	12.2	17.1	3.2	3.5	3.9	2.1	3.1	3.9	4.1	4.1	4.1	3.4	3.8	1.6	3.6
Blood Eosinophil Count	2.2	16.7	23.0	2.6	4.6	4.5	2.4	4.3	4.8	4.7	4.8	4.8	3.0	4.2	3.8	3.5
Leg fat-free mass (right)	2.2	11.9	16.8	3.2	3.4	3.9	2.1	3.1	3.8	4.1	4.1	4.0	3.4	3.8	1.5	3.5
Medication: Levothyroxine sodium	2.1	3.5	6.1	2.4	1.4	1.8	1.3	1.6	1.8	1.8	1.8	1.9	2.5	2.0	0.7	2.5
Impedance of arm (left)	2.1	9.8	14.8	-3.9	-2.8	-3.2	-1.9	-2.7	-2.9	-3.4	-3.2	-3.2	-3.8	-3.5	-2.1	-3.3
Leg fat-free mass (left)	2.0	10.4	14.9	3.0	3.2	3.6	1.8	2.8	3.7	3.8	3.9	3.8	3.0	3.5	1.4	3.4
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.6	8.8	3.0	1.9	2.2	0.1	2.4	1.7	2.1	1.9	2.0	2.7	2.4	-1.9	2.4
Mouth/teeth dental problems: Loose teeth	2.0	2.4	3.5	1.5	1.6	1.7	0.6	1.8	1.4	1.7	1.6	1.6	1.9	1.7	1.0	1.4
Qualifications: CSEs or equivalent	1.9	2.5	3.8	1.1	1.9	1.8	1.2	1.8	1.8	1.8	1.9	1.9	0.9	1.6	0.7	1.4
Leg predicted mass (left)	1.9	10.3	14.9	2.9	3.2	3.6	1.8	2.8	3.7	3.8	3.9	3.8	3.0	3.5	1.4	3.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	3.9	8.7	2.9	2.2	2.0	2.1	1.9	1.7	1.6	1.7	1.7	2.4	2.2	0.7	1.9
Forced vital capacity (FVC)	1.8	7.0	10.8	1.8	2.9	2.7	1.0	3.1	3.0	3.1	3.2	3.3	2.5	2.8	1.2	2.7
Peak expiratory flow (PEF)	1.8	4.2	6.7	2.3	2.4	2.1	1.2	2.2	1.9	2.2	2.1	2.1	2.0	2.1	0.1	2.6
Medication: Ventolin 100micrograms inhaler	1.8	2.3	4.4	1.0	1.5	1.7	1.1	1.5	1.7	1.6	1.6	1.7	1.0	1.5	2.1	1.4
Number of full brothers	1.8	2.3	3.2	-1.3	-1.6	-1.7	-1.2	-1.6	-1.7	-1.8	-1.8	-1.8	-1.3	-1.7	-0.4	-1.3
Mouth/teeth dental problems: Mouth ulcers	1.8	2.9	11.8	-0.1	1.7	1.5	2.2	1.2	1.8	1.6	1.8	1.8	0.2	1.2	3.4	0.3
Average weekly champagne plus white wine intake	1.8	2.4	4.3	-1.7	-1.7	-1.3	-2.1	-1.8	-1.2	-1.5	-1.5	-1.4	-1.9	-1.5	-1.0	-1.0
Mother’s age at death	1.7	2.2	4.7	0.7	1.8	1.6	1.7	1.0	1.7	1.4	1.5	1.6	0.5	1.4	2.2	1.2
High cholesterol (Self-reported)	1.7	3.1	5.4	-0.3	-2.1	-2.0	-2.3	-1.6	-2.3	-1.8	-1.9	-2.0	-0.3	-1.6	-2.2	-0.5
Ever depressed for a whole week	1.7	2.1	11.9	-0.2	1.7	1.1	1.8	1.3	1.3	1.2	1.1	1.0	0.2	0.8	3.5	0.1
Ulcerative Colitis	1.6	2.4	6.1	1.5	1.5	1.6	1.6	1.0	1.9	1.2	1.4	1.4	1.2	1.6	2.5	1.2
Respiratory disease	1.6	3.5	5.2	1.4	1.7	1.8	1.1	2.1	1.6	2.3	2.2	2.2	2.0	1.9	1.5	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.2	7.7	2.4	2.4	2.2	1.3	2.6	2.0	2.5	2.5	2.6	2.8	2.4	0.3	2.7
Number of children fathered	1.6	1.8	2.6	1.2	1.3	1.6	1.5	1.2	1.4	1.5	1.5	1.4	1.0	1.5	-1.0	1.3
Bipolar Disorder (2018)	1.5	2.3	3.9	-1.6	-1.7	-2.0	-0.9	-1.4	-1.9	-1.6	-1.7	-1.6	-0.9	-1.8	-0.5	-1.4
Alzheimer’s Disease (including proxy)	1.5	2.2	4.3	-2.1	-1.3	-1.4	-0.6	-1.5	-1.2	-1.5	-1.3	-1.4	-2.0	-1.7	-1.2	-1.5
Chronotype (morning person)	1.5	3.5	5.6	-0.7	-2.2	-2.0	-1.1	-2.2	-2.4	-2.4	-2.3	-2.3	-1.0	-1.9	-1.6	-1.1
Hand grip strength (left)	1.5	3.8	4.8	1.9	1.9	2.0	1.9	1.7	2.2	2.0	2.1	2.1	1.9	2.1	1.4	2.1
Relative age of first facial hair	1.5	3.0	7.6	-1.2	-2.2	-1.9	-1.5	-1.6	-2.0	-1.6	-1.7	-1.7	-0.7	-1.6	-2.8	-1.3
Fed-up feelings	1.5	2.7	6.6	2.6	1.7	1.3	1.5	1.5	1.1	1.4	1.4	1.3	2.3	1.7	1.5	1.4
Intelligence (Savage-Jansen 2018)	1.4	4.2	6.0	-1.7	-1.9	-2.1	-1.5	-2.3	-2.1	-2.3	-2.3	-2.5	-1.7	-2.2	-1.5	-2.0
Number of live births	1.4	2.0	4.3	-1.9	-1.2	-1.3	-1.3	-1.1	-1.2	-1.0	-1.1	-1.1	-1.6	-1.4	-1.7	-2.1
Happiness	1.4	1.7	2.8	1.5	1.3	1.4	0.5	1.3	1.3	1.2	1.4	1.3	1.2	1.5	0.9	1.7
Prospective memory result	1.4	1.7	3.1	1.3	1.2	1.0	-0.0	1.8	1.0	1.6	1.5	1.6	1.7	1.4	0.3	1.5
Pulse wave reflection index	1.4	1.8	2.8	1.3	1.5	1.5	0.4	1.7	1.2	1.5	1.3	1.3	1.1	1.4	1.3	1.4
Health satisfaction	1.4	1.9	2.9	0.9	1.1	1.4	1.1	1.5	1.5	1.6	1.7	1.6	1.1	1.3	1.3	1.5
Leg pain on walking	1.4	1.7	2.5	1.0	1.1	1.2	1.1	1.5	1.1	1.6	1.6	1.6	1.6	1.3	1.1	1.2
Whole body fat-free mass	1.4	7.8	11.3	2.6	2.7	3.2	1.4	2.3	3.1	3.3	3.4	3.3	2.7	3.0	1.1	3.0
Breast cancer (self-reported)	1.4	1.7	3.2	0.8	1.7	1.6	0.3	0.9	1.8	1.3	1.5	1.4	0.7	1.3	1.8	1.0
Asthma (self-reported)	1.4	2.8	3.6	1.2	1.4	1.7	1.5	1.7	1.7	1.9	1.9	1.9	1.3	1.7	1.7	1.9
Whole body water mass	1.4	8.1	11.4	2.7	2.8	3.2	1.6	2.4	3.2	3.4	3.4	3.3	2.8	3.1	1.1	3.1
Verbal and Numeric Reasoning (VNR)	1.3	3.0	3.6	-1.6	-1.7	-1.8	-1.7	-1.8	-1.8	-1.8	-1.9	-1.8	-1.4	-1.8	-1.7	-1.6
Hypothyroidism (self reported)	1.3	3.0	6.3	1.5	1.5	1.8	1.3	1.6	2.0	1.7	1.9	1.8	1.8	1.7	0.6	2.5
Age when periods started (menarche)	1.3	3.1	6.7	-0.9	-1.8	-2.3	-1.3	-1.2	-2.5	-1.6	-2.0	-2.0	-0.3	-1.9	-2.6	-0.9
Medication: Lansoprazole	1.3	1.5	4.8	-1.2	-1.4	-1.6	0.1	-0.8	-1.8	-0.9	-1.0	-1.0	-0.7	-1.2	-2.2	-0.1
Headache pain in last month	1.3	2.2	3.0	-1.5	-1.6	-1.6	-1.1	-1.7	-1.4	-1.7	-1.7	-1.6	-1.3	-1.7	-0.2	-1.4
Hearing difficulty/problems: Yes	1.2	1.9	3.7	0.9	1.5	1.5	1.3	1.6	1.5	1.4	1.4	1.4	0.7	1.4	1.9	0.7
Trunk fat percentage	1.2	4.7	9.3	-2.7	-1.9	-1.9	-1.5	-2.3	-1.6	-1.8	-1.7	-1.8	-2.6	-2.2	-2.3	-3.1
Impedance of arm (right)	1.2	5.7	10.6	-3.2	-2.0	-2.4	-1.1	-2.1	-2.0	-2.6	-2.4	-2.4	-3.3	-2.7	-1.3	-2.6
Asthma	1.2	2.4	3.3	1.0	1.3	1.6	1.5	1.6	1.6	1.8	1.8	1.8	1.2	1.6	1.5	1.7
High blood pressure (siblings)	1.2	1.8	4.1	-2.0	-1.5	-1.6	-0.6	-1.4	-1.2	-1.1	-1.1	-1.1	-1.5	-1.6	-0.1	-1.6
Forced vital capacity (FVC), Best measure	1.2	4.5	6.9	1.9	2.1	2.0	0.9	2.4	1.9	2.4	2.4	2.5	2.5	2.2	0.7	2.6
Age at first live birth	1.2	2.2	8.3	1.9	1.1	1.2	0.3	0.8	1.2	1.1	1.2	1.2	2.0	1.5	1.2	2.9
Medication: Blood pressure	1.2	2.0	4.6	-2.2	-1.3	-1.6	-1.1	-1.1	-1.4	-1.3	-1.2	-1.3	-1.5	-1.7	-1.4	-1.1
Commuting to job workplace: Walk	1.2	1.3	3.2	-1.3	-1.1	-1.2	-1.3	-0.9	-1.0	-1.1	-1.0	-1.0	-1.2	-1.3	0.1	-1.8
Number of self-reported non-cancer illnesses	1.2	2.1	3.6	-1.8	-1.8	-1.6	-1.9	-1.3	-1.6	-1.1	-1.1	-1.2	-1.1	-1.6	-1.7	-0.8
Alcohol drinker status: Never	1.2	1.5	3.0	-1.4	-1.1	-0.9	-0.1	-1.4	-0.6	-1.4	-1.1	-1.1	-1.7	-1.2	1.1	-1.6
Number of operations (self-reported)	1.2	1.8	5.1	-1.9	-1.0	-1.2	0.1	-1.1	-1.1	-1.1	-1.2	-1.2	-1.9	-1.4	-0.5	-2.3
Primary Biliary Cirrhosis	1.1	1.6	6.9	-0.8	-1.3	-1.0	-1.9	-0.9	-1.0	-0.9	-1.0	-1.0	-0.6	-1.1	-2.6	-0.9
Alcohol usually taken with meals	1.1	1.7	2.7	-1.2	-1.3	-1.4	-0.9	-1.5	-1.4	-1.6	-1.6	-1.6	-1.3	-1.5	-0.6	-0.4
Mouth/teeth dental problems	1.1	1.6	3.5	0.2	-1.5	-1.5	-1.3	-1.2	-1.9	-1.3	-1.6	-1.7	0.1	-1.1	-1.3	-0.2
Trunk fat-free mass	1.1	6.5	9.0	2.5	2.5	2.9	1.4	2.1	2.8	3.0	3.0	3.0	2.5	2.8	0.9	2.9
Depression (self-reported)	1.1	1.3	2.0	-0.8	-1.2	-1.3	-1.1	-1.2	-1.4	-1.3	-1.3	-1.3	-0.9	-1.2	-0.8	-0.3
Trunk predicted mass	1.1	6.4	8.9	2.5	2.5	2.9	1.4	2.1	2.8	3.0	3.0	2.9	2.4	2.8	0.9	2.9
Gout (self-reported)	1.1	1.5	4.7	2.2	1.0	1.1	1.2	1.4	0.7	1.1	0.9	0.8	1.8	1.3	-0.3	1.0
Chronic bronchitis/emphysema (mother)	1.1	1.2	3.5	-1.8	-0.8	-0.7	-1.7	-1.0	-0.2	-0.7	-0.5	-0.5	-1.9	-1.0	0.3	-1.5
Body fat percentage	1.1	4.5	9.8	-2.6	-1.9	-1.9	-1.3	-2.4	-1.6	-1.8	-1.7	-1.8	-2.5	-2.2	-2.1	-3.1
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	2.0	1.1	1.4	1.1	1.3	1.4	1.0	1.2	1.3	1.3	1.0	1.2	0.7	1.0
Pain type(s) experienced in last month: Hip pain	1.1	1.4	2.1	1.4	1.0	1.1	1.4	1.2	0.9	1.2	1.1	1.2	1.3	1.2	0.5	1.4
Average weekly beer plus cider intake	1.1	1.6	3.1	1.7	0.9	1.2	0.4	1.5	1.3	1.4	1.4	1.3	1.8	1.4	0.5	0.8
Schizophrenia vs Biploar Disorder	1.0	1.3	1.8	1.3	0.8	1.1	1.0	1.3	1.2	1.2	1.3	1.2	0.9	1.2	-1.3	0.9
Body Mass Index (BMI) (2010)	1.0	1.4	2.4	0.9	1.0	1.5	0.8	1.0	1.5	1.3	1.4	1.5	1.0	1.4	1.0	0.8
Lung FVC	1.0	5.3	7.6	1.5	2.5	2.4	1.4	2.6	2.8	2.5	2.7	2.7	1.8	2.4	2.2	1.7
Taking other prescription medications	1.0	1.5	2.4	1.0	1.1	1.2	0.6	1.1	1.3	1.2	1.2	1.3	1.4	1.2	1.5	1.6
Chronic bronchitis/emphysema (father)	1.0	1.2	7.4	-0.0	0.8	1.0	1.5	0.6	1.3	0.7	0.9	0.9	-0.3	0.6	2.7	-0.3
Nervous feelings	1.0	1.8	2.6	1.3	1.5	1.4	1.2	1.6	1.4	1.5	1.5	1.5	1.1	1.5	0.5	1.0
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	4.3	2.0	1.3	1.7	-0.3	1.8	1.3	1.4	1.3	1.3	1.5	1.7	-2.1	1.3
Illnesses of siblings	1.0	1.4	2.1	1.4	1.4	1.2	1.1	1.3	1.1	1.0	1.0	1.1	1.2	1.3	-0.4	1.3
Qualifications: A levels/AS levels or equivalent	1.0	2.2	4.4	-1.2	-1.5	-1.4	-1.3	-2.1	-1.3	-1.9	-1.8	-1.9	-1.4	-1.6	0.0	-0.8
Length of working week for main job	1.0	1.1	3.6	-1.4	-0.9	-1.0	-1.9	-0.7	-0.8	-0.9	-0.8	-0.7	-1.1	-1.1	-0.7	-1.1
Basal metabolic rate	1.0	5.6	8.5	2.1	2.3	2.7	1.2	1.8	2.8	2.9	2.9	2.8	2.1	2.6	0.7	2.4
Blood Platelet Count	0.9	10.4	12.6	-3.5	-3.5	-3.1	-2.8	-3.5	-2.9	-3.3	-3.3	-3.3	-3.5	-3.4	-2.2	-3.4
Blood Red Count	0.9	8.7	16.3	-3.8	-2.6	-2.9	-1.6	-2.8	-2.4	-3.0	-2.9	-2.7	-3.7	-3.0	-1.8	-4.0
Tinnitus: Yes, but not now, but have in the past	0.9	1.0	2.3	-1.5	-0.9	-0.9	-0.2	-0.4	-0.8	-0.7	-0.8	-0.8	-1.5	-1.1	1.3	-1.0
Exposure to tobacco smoke at home	0.9	1.1	2.4	-1.1	-1.1	-0.8	-0.5	-1.1	-0.5	-1.0	-1.0	-1.0	-1.5	-1.0	0.2	-1.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	2.5	1.6	1.2	1.5	0.7	1.2	1.4	1.2	1.2	1.3	1.1	1.5	0.6	0.5
Medication: Seretide 50 evohaler	0.9	1.0	2.5	0.6	1.6	1.2	1.3	0.7	1.2	0.9	0.9	0.8	0.3	1.0	1.5	-0.1
Supplements: Vitamin C	0.9	1.1	1.6	0.6	1.2	1.2	0.4	0.7	1.3	1.2	1.1	1.1	0.4	1.1	1.2	1.2
Ever taken oral contraceptive pill	0.9	1.0	1.8	1.1	1.0	1.3	0.8	0.9	1.3	1.0	0.9	0.9	0.9	1.2	0.7	0.4
Illnesses of father: High blood pressure	0.9	1.1	1.6	-1.2	-1.0	-1.2	-1.0	-1.0	-1.1	-1.0	-1.1	-1.1	-0.9	-1.1	-0.5	-1.3
Medication: Omeprazole (e.g. Zanprol)	0.9	1.2	3.4	-1.1	-0.9	-1.2	-0.9	-0.6	-1.2	-0.8	-1.0	-0.8	-0.8	-1.1	-1.8	-1.1
Angina	0.8	1.1	1.4	-0.7	-0.8	-1.2	-1.1	-1.1	-1.2	-1.2	-1.2	-1.2	-0.7	-1.1	-0.9	-1.0
Serious illness, injury or assault to yourself	0.8	1.0	1.3	1.1	1.0	1.1	0.3	1.1	0.9	1.2	1.1	1.0	1.0	1.1	1.0	1.1
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	4.3	0.6	1.1	0.7	0.7	0.9	0.8	0.8	0.8	0.7	0.9	0.8	2.1	1.1
Allergy	0.8	1.9	3.8	-0.6	-1.0	-1.2	-1.6	-1.4	-1.1	-1.6	-1.6	-1.6	-0.9	-1.2	-2.0	-1.6
Diabetes (self-reported)	0.8	1.3	3.7	1.6	0.8	0.8	1.2	1.0	0.4	0.9	0.8	0.7	1.4	1.0	-1.2	1.9
Comparative body size at age 10	0.8	2.1	5.3	1.3	1.3	1.6	2.3	1.1	1.6	1.4	1.5	1.4	0.8	1.6	1.1	1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.0	-0.8	-0.9	-0.9	-0.6	-0.9	-0.9	-0.9	-1.0	-1.0	-0.8	-0.9	-1.4	-1.0
Illnesses of siblings: Diabetes	0.8	1.0	2.9	-0.8	-1.0	-0.9	-1.7	-1.3	-0.9	-1.0	-1.0	-1.0	-0.9	-1.0	-0.3	-0.8
Loneliness, isolation	0.8	1.0	2.4	-1.4	-0.9	-0.9	-0.5	-1.1	-0.6	-1.0	-0.9	-0.9	-1.5	-1.1	-0.1	-1.5
Medication: Gliclazide	0.8	0.9	1.7	1.0	1.3	1.0	0.5	1.0	0.9	0.9	0.9	0.9	0.9	1.1	-0.6	1.3
Arm fat-free mass (left)	0.8	4.3	6.7	1.9	2.1	2.5	0.8	1.5	2.5	2.5	2.6	2.5	1.7	2.3	1.0	1.9
Neuroticism (2016)	0.7	1.0	3.0	0.5	1.4	1.5	0.5	1.0	1.7	1.0	1.1	1.1	-0.4	1.1	0.2	0.4
Triglycerides	0.7	1.2	4.9	-0.4	-1.2	-1.1	-1.1	-0.9	-1.4	-0.8	-1.0	-1.0	-0.0	-0.7	-2.2	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	1.8	1.1	0.8	0.9	-0.4	1.0	0.8	1.1	1.1	1.0	1.2	1.1	0.7	1.4
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.8	-0.8	-0.8	-0.5	0.0	-1.0	-0.7	-0.9	-0.9	-0.9	-1.7	-0.9	-0.4	-1.1
Supplements: Glucosamine	0.7	1.0	1.8	0.9	1.0	1.3	0.7	0.7	1.4	1.1	1.2	1.1	0.6	1.2	0.2	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.2	2.0	1.0	1.4	1.2	0.1	1.2	1.1	1.2	1.3	1.3	0.8	1.2	0.6	1.0
Hair/balding pattern: Pattern 3	0.7	1.0	1.9	1.4	1.1	1.3	0.4	1.1	1.1	0.9	0.8	0.8	0.7	1.2	-0.6	0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.8	1.6	-0.6	1.2	0.9	0.4	0.8	1.3	1.0	1.2	1.2	-0.0	0.6	1.2	0.6
Pulse rate, automated reading	0.7	2.2	4.1	-0.9	-1.8	-1.8	-1.1	-1.7	-2.0	-1.6	-1.6	-1.7	-0.3	-1.6	-1.5	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.8	0.1	1.0	0.8	1.1	0.8	0.8	1.0	1.1	1.1	0.5	0.7	1.4	0.0
Long-standing illness, disability or infirmity	0.7	1.0	1.9	-0.1	1.1	1.0	1.0	0.9	1.2	1.2	1.3	1.3	-0.0	0.7	1.4	0.8
Diabetes diagnosed by doctor	0.7	1.1	2.9	1.4	0.7	0.8	1.4	1.1	0.5	0.9	0.8	0.7	1.3	0.9	-0.7	1.7
Financial situation satisfaction	0.7	0.9	1.6	1.1	1.3	1.2	0.3	0.9	1.1	0.8	1.0	1.0	0.5	1.2	-0.2	0.5
Arm predicted mass (left)	0.7	3.8	6.0	1.7	2.0	2.3	0.7	1.4	2.4	2.4	2.4	2.4	1.6	2.1	0.9	1.9
Bipolar Disorder or Schizophrenia	0.6	1.5	2.6	-1.6	-1.2	-1.4	-0.8	-0.9	-1.3	-1.3	-1.4	-1.2	-1.2	-1.4	-0.6	-1.5
Irritable Bowel Disease (IBD)	0.6	1.3	7.3	-0.4	1.4	0.9	0.8	0.1	1.9	0.5	1.0	1.0	-0.6	0.7	2.7	-0.1
Ulcerative Colitis (UC)	0.6	1.1	6.0	0.2	1.2	1.1	1.0	0.2	1.6	0.5	0.8	0.8	-0.3	0.8	2.4	0.1
Major Depression (MDD)	0.6	0.7	2.6	-0.9	0.8	0.7	0.9	0.5	1.2	0.6	0.7	0.7	-0.9	0.3	1.6	-0.4
Reaction Time	0.6	1.2	5.8	0.5	-0.5	-0.9	-2.0	-0.6	-1.2	-0.5	-0.8	-0.7	0.6	-0.6	-2.4	0.5
Crohns Disease (2012)	0.6	0.9	3.0	-0.0	1.1	1.0	0.4	0.2	1.7	0.8	1.1	1.0	-0.3	0.9	1.7	-0.1
Fasting Glucose	0.6	0.7	2.1	-0.9	0.8	0.7	0.9	0.8	1.5	-0.6	0.3	1.4	-0.6	0.1	0.1	-0.7
LDL Cholesterol	0.6	1.0	2.8	-0.1	-1.3	-0.9	-1.1	-0.7	-1.5	-0.9	-1.0	-1.1	-0.1	-0.6	-1.7	-0.1
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.6	0.3	0.9	0.8	1.4	1.2	0.8	1.3	1.3	1.3	1.0	0.9	1.9	1.5
Stomach or abdominal pain in last month	0.6	0.8	1.2	-0.5	-0.9	-1.0	-0.1	-1.0	-0.9	-1.0	-1.0	-1.0	-0.7	-0.9	1.1	-0.8
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	3.9	-0.6	0.6	0.6	2.0	0.6	0.8	0.7	0.7	0.7	-0.3	0.3	1.7	-0.1
Worrier / anxious feelings	0.6	1.1	2.4	1.3	0.8	0.7	0.4	1.3	0.5	1.1	1.0	0.9	1.6	1.0	0.5	1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.9	0.5	1.4	0.9	1.1	1.3	0.7	1.1	1.1	1.0	0.3	0.9	1.1	0.2
Angina (self-reported)	0.6	0.8	1.0	-0.6	-0.6	-1.0	-0.9	-1.0	-0.9	-1.0	-1.0	-1.0	-0.7	-0.9	-0.5	-1.0
Alcohol intake frequency.	0.6	1.5	3.8	-0.6	-1.2	-0.7	-0.2	-1.9	-0.4	-1.6	-1.3	-1.4	-1.3	-1.1	0.8	-1.9
Medication: Blood pressure	0.6	1.1	2.2	-1.4	-1.0	-1.0	-1.2	-0.9	-1.0	-0.8	-0.8	-0.8	-1.3	-1.1	-1.5	-0.7
Allergy or Eczema	0.5	1.2	3.1	-0.1	0.6	0.6	1.6	1.2	0.4	1.2	1.1	1.1	0.8	0.7	1.6	1.8
Type 2 Diabetes (T2D) (2018)	0.5	0.9	3.6	1.5	0.9	0.8	0.4	0.9	0.4	0.8	0.6	0.6	1.1	0.9	-0.5	1.9
Ever had hysterectomy (womb removed)	0.5	0.6	3.8	-0.9	-0.1	0.3	-0.4	-0.5	0.4	-0.3	-0.3	-0.2	-1.9	-0.4	-0.6	-1.3
Supplements: Zinc	0.5	0.6	1.4	-0.1	1.2	0.8	1.0	0.8	0.7	0.8	0.8	0.7	-0.3	0.6	0.9	-0.0
Hand grip strength (right)	0.5	1.5	3.1	0.9	1.3	1.5	1.2	0.8	1.8	1.2	1.4	1.3	0.4	1.2	1.0	1.1
Maternal smoking around birth	0.5	0.7	1.5	0.3	0.2	1.0	0.9	0.7	1.2	1.0	1.1	1.0	0.5	0.9	-0.4	0.1
Pulse rate	0.5	0.8	3.0	-0.4	-1.1	-1.0	-0.8	-0.9	-1.2	-0.9	-0.8	-0.8	0.2	-0.7	-1.7	-0.0
Pulse wave Arterial Stiffness index	0.5	0.6	1.5	-0.7	-0.9	-0.9	-0.9	-0.3	-1.2	-0.7	-0.8	-0.7	-0.5	-0.8	-0.6	-0.6
Neck or shoulder pain in last month	0.5	0.7	2.0	-1.3	-0.6	-0.6	0.2	-0.7	-0.5	-0.6	-0.6	-0.6	-1.4	-0.9	-0.6	-1.4
Leg fat mass (right)	0.5	1.9	3.9	-1.4	-1.3	-1.1	-1.2	-1.9	-0.9	-1.1	-1.0	-1.1	-1.6	-1.3	-1.5	-2.0
Age at last live birth	0.5	0.7	3.6	1.4	-0.2	-0.1	-0.4	-0.5	-0.4	-0.2	-0.4	-0.4	1.3	0.3	-0.7	1.9
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.3	0.4	1.1	0.7	0.3	1.0	1.0	0.8	0.9	0.8	0.7	0.8	0.9	0.6
Hypertension (Self-reported)	0.5	1.3	4.5	-1.3	-1.2	-1.0	-0.5	-0.9	-1.1	-0.9	-1.0	-1.0	-1.0	-1.1	-2.1	-0.8
Smoking status: Previous	0.5	0.7	3.7	-0.4	-0.5	-0.8	-1.6	-0.0	-0.9	-0.4	-0.5	-0.5	0.3	-0.6	-1.9	-0.3
Mood swings	0.5	0.9	4.3	1.7	0.3	0.1	-0.8	0.9	-0.5	0.7	0.5	0.5	2.1	0.7	-0.4	0.8
Back pain experienced in last month	0.5	0.7	1.3	-1.1	-0.7	-1.0	-0.6	-0.9	-0.9	-0.8	-0.7	-0.7	-0.6	-0.9	-0.9	-1.0
Wears glasses or contact lenses	0.5	0.6	1.6	-1.0	-0.8	-0.6	-0.2	-0.6	-0.7	-0.8	-0.8	-0.8	-1.3	-0.8	0.3	-0.6
Leg fat mass (left)	0.5	1.8	3.9	-1.4	-1.2	-1.0	-1.2	-1.8	-0.8	-1.0	-0.9	-1.0	-1.5	-1.3	-1.5	-2.0
Lung FEV1/FVC ratio	0.4	1.8	10.2	1.7	1.0	0.7	0.5	1.1	0.3	0.9	0.7	0.8	1.7	1.0	-3.2	1.2
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.3	-0.2	0.4	0.5	0.4	1.0	0.4	1.1	0.9	1.0	0.4	0.5	-0.1	1.2
Townsend deprivation index at recruitment	0.4	0.6	2.1	-0.6	-0.5	-0.3	-1.1	-1.1	-0.1	-0.6	-0.5	-0.6	-1.0	-0.6	0.4	-1.4
Current tobacco smoking	0.4	0.6	1.7	0.6	0.5	1.1	1.3	0.7	1.2	0.8	0.9	0.8	0.3	0.9	-0.1	0.3
High blood pressure	0.4	1.1	3.9	-1.2	-1.1	-0.8	-0.6	-0.9	-0.8	-0.8	-0.8	-0.9	-1.0	-1.0	-2.0	-0.9
Medication: Atenolol	0.4	0.5	0.8	-0.3	-0.7	-0.8	-0.8	-0.7	-0.9	-0.6	-0.7	-0.7	-0.5	-0.7	-0.6	-0.5
Trunk fat mass	0.4	1.7	4.1	-1.7	-1.1	-1.0	-0.9	-1.5	-0.7	-0.7	-0.7	-0.8	-1.6	-1.2	-2.0	-1.9
Past tobacco smoking	0.4	0.8	3.5	0.7	0.7	0.9	1.4	0.5	0.8	0.6	0.7	0.7	0.2	0.8	1.9	0.5
Financial difficulties in last 2 years	0.4	0.6	1.4	0.4	0.7	0.7	1.2	0.8	0.7	0.9	0.9	0.9	0.5	0.8	-0.7	0.1
Heart attack	0.4	0.5	3.1	0.2	-0.6	-0.7	-0.7	-0.2	-1.0	-0.1	-0.2	-0.2	0.5	-0.3	-1.8	0.5
Medication: Simvastatin	0.4	0.6	1.8	0.2	-0.8	-1.0	-0.7	-0.6	-1.4	-0.6	-0.7	-0.7	0.4	-0.6	-1.1	0.8
Time employed in main current job	0.4	0.4	1.0	0.5	0.9	0.5	0.4	1.0	0.3	0.7	0.6	0.7	1.0	0.7	0.1	0.0
Father’s age at death	0.4	0.5	1.1	0.9	0.5	0.4	1.0	0.5	0.5	0.3	0.5	0.5	1.0	0.7	0.4	1.1
Falls in the last year	0.4	0.5	0.8	0.7	0.8	0.7	-0.2	0.8	0.6	0.9	0.9	0.9	0.9	0.8	0.1	0.1
Illnesses of mother	0.4	0.6	1.2	1.1	-0.5	-0.6	-0.4	-0.3	-1.1	-0.8	-0.9	-0.9	0.7	-0.4	-1.0	0.3
Medication: Amlodipine	0.4	0.6	1.6	-0.4	0.3	0.5	1.3	1.0	0.7	1.1	1.1	1.1	0.4	0.6	0.3	0.3
Arm fat-free mass (right)	0.4	2.3	3.8	1.4	1.4	1.8	0.3	1.0	1.8	1.9	2.0	1.9	1.3	1.7	0.3	1.4
Worry too long after embarrassment	0.4	0.7	2.4	-0.4	-0.7	-0.7	-1.6	-0.7	-0.9	-0.9	-0.8	-0.8	-0.8	-0.8	-0.8	-0.1
Pulse wave peak to peak time	0.4	0.5	1.3	0.5	0.8	0.8	0.7	0.3	1.1	0.6	0.8	0.7	0.5	0.7	0.5	0.5
Medication: Ibuprofen	0.4	0.4	1.7	1.3	0.7	0.5	-0.2	0.1	0.4	0.2	0.2	0.1	1.1	0.5	-0.2	1.2
Medication: Allopurinol	0.4	0.5	1.5	1.2	0.2	0.5	1.2	0.7	0.4	0.6	0.5	0.5	1.0	0.7	0.7	0.6
Medication: Omeprazole	0.4	0.5	1.2	-0.7	-0.5	-0.8	-0.7	-0.3	-0.7	-0.6	-0.7	-0.6	-0.6	-0.7	-0.8	-1.1
Heart disease (mother)	0.4	0.5	2.9	-0.7	-1.0	-0.7	-0.5	-0.3	-0.7	-0.3	-0.5	-0.5	-0.3	-0.6	-1.7	-0.2
Arm predicted mass (right)	0.4	2.1	3.8	1.3	1.4	1.8	0.1	1.0	1.8	1.9	1.9	1.9	1.3	1.6	0.1	1.3
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.2	-0.5	-0.8	-1.0	-0.4	-0.5	-1.1	-0.7	-0.7	-0.6	-0.0	-0.7	-0.9	0.4
Qualifications: nursing, teaching	0.4	0.6	1.2	-0.0	-1.0	-0.2	0.6	-0.9	-0.4	-1.0	-1.1	-1.1	-0.9	-0.5	0.5	-0.4
Osteoporosis (self-reported)	0.4	0.5	2.6	-1.6	-0.4	-0.8	-0.1	-0.3	-0.3	-0.3	-0.3	-0.3	-1.0	-0.9	0.3	-0.9
Illnesses of father: None of the above (group 1)	0.4	0.4	2.2	0.4	-0.9	-0.3	-1.2	-0.3	-0.6	-0.4	-0.4	-0.5	0.3	-0.1	-1.5	0.1
Smoking status: Current	0.4	0.6	2.1	0.4	0.5	1.0	1.4	0.6	1.1	0.7	0.8	0.7	0.1	0.8	-0.1	0.2
Depression (Nagel 2018)	0.3	0.5	2.5	0.9	0.4	0.5	-0.3	0.7	0.4	0.6	0.6	0.6	0.7	0.6	-0.1	1.6
Crohns Disease (2017)	0.3	0.7	2.7	-0.8	0.9	0.5	0.2	0.1	1.4	0.6	1.0	0.9	-0.6	0.5	1.7	-0.3
HbA1C	0.3	0.3	1.0	-0.9	-0.3	-0.4	0.2	-0.6	-0.2	0.6	0.3	-0.4	-1.0	-0.7	-0.0	-0.3
HDL Cholesterol	0.3	0.5	1.2	-0.7	-0.4	-0.5	-0.2	-0.9	-0.5	-0.9	-0.7	-0.7	-1.1	-0.6	0.7	-0.7
Lupus	0.3	0.4	1.5	-0.0	-0.6	-0.8	-0.4	-0.5	-0.8	-0.5	-0.6	-0.6	-0.0	-0.6	-1.2	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.7	0.1	0.6	0.5	0.1	0.7	0.6	0.8	0.8	0.8	0.5	0.4	0.3	0.4
Blood White Count	0.3	1.9	6.5	1.8	-0.0	0.3	0.2	1.4	0.1	1.1	0.8	0.6	2.5	0.9	-2.5	1.9
Heel T-Score	0.3	2.3	7.3	2.6	0.1	0.8	-0.8	1.1	0.3	0.8	0.7	0.8	2.7	1.4	-2.6	1.4
Number of treatments/medications taken	0.3	0.5	1.1	-0.7	-0.9	-1.1	-0.9	-0.8	-0.9	-0.6	-0.6	-0.6	-0.1	-0.8	0.2	0.1
Average weekly spirits intake	0.3	0.4	4.6	-0.1	0.1	0.1	2.2	0.3	0.1	0.3	0.3	0.3	0.2	0.1	0.5	0.4
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.7	-0.4	0.7	0.4	1.3	0.7	0.3	0.5	0.4	0.5	-0.8	0.2	0.4	-0.7
Systolic blood pressure, automated reading	0.3	0.8	2.0	-1.0	1.1	0.9	0.4	0.4	1.4	0.8	1.1	1.1	-0.6	0.5	1.0	-0.4
Vitamin and mineral supplements	0.3	0.4	1.2	0.8	0.5	0.4	1.1	0.7	0.4	0.3	0.3	0.4	0.6	0.5	-0.7	0.4
Diabetes (mother)	0.3	0.4	2.0	1.1	-0.1	0.1	0.4	0.1	-0.1	0.3	0.2	0.1	1.1	0.3	-0.4	1.4
Pack years adult smoking proportion	0.3	0.5	1.6	1.2	0.8	0.8	-0.1	0.5	0.7	0.5	0.5	0.4	0.6	0.7	-0.3	0.8
Average weekly fortified wine intake	0.3	0.4	2.0	-0.8	0.0	0.1	1.4	0.1	0.5	0.3	0.4	0.5	-0.3	0.0	1.3	0.1
Relative age voice broke	0.3	0.4	0.8	-0.9	-0.8	-0.8	-0.6	-0.2	-0.7	-0.3	-0.4	-0.3	-0.2	-0.7	-0.9	-0.6
Fluid intelligence score	0.3	0.7	1.5	-0.4	-0.9	-1.0	-1.2	-1.1	-1.0	-0.9	-1.0	-0.9	0.0	-0.8	-0.2	0.1
Hip circumference	0.3	1.1	2.7	0.2	1.2	1.4	1.1	0.4	1.6	1.4	1.5	1.4	0.0	1.0	0.5	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	0.9	0.3	0.6	0.4	0.0	0.8	0.2	0.9	0.9	0.9	0.6	0.5	0.6	1.0
Mouth/teeth dental problems: Dentures	0.3	0.5	4.2	-0.6	-0.7	-0.6	-0.6	-0.2	-0.5	-0.4	-0.4	-0.3	-0.3	-0.6	-2.0	-0.5
Lung cancer (father)	0.3	0.3	0.7	0.7	0.0	0.8	0.4	0.3	0.6	0.6	0.6	0.6	0.6	0.8	0.5	0.3
Birth weight of first child	0.3	0.5	0.9	0.2	0.8	0.6	0.8	0.9	0.4	1.0	0.8	0.9	1.0	0.7	0.3	0.6
Mean time to correctly identify matches	0.3	0.6	2.5	0.5	-0.3	-0.6	-1.5	-0.1	-1.0	-0.1	-0.4	-0.3	0.7	-0.3	-1.6	0.5
Number of full sisters	0.3	0.4	1.5	-0.9	-0.0	-0.2	-0.4	-0.7	0.0	-0.4	-0.3	-0.2	-1.2	-0.5	0.9	-1.0
Chest pain or discomfort	0.3	0.5	1.0	-0.1	0.6	0.8	-0.1	0.7	0.9	0.8	0.9	0.9	-0.1	0.6	1.0	-0.4
Forced expiratory volume in 1-second (FEV1), predicted	0.3	0.7	1.0	0.7	0.8	0.9	0.1	0.7	0.9	0.9	1.0	1.0	0.9	0.9	-0.8	0.7
Ever had bowel cancer screening	0.3	0.3	1.6	-1.0	0.3	-0.1	1.3	0.6	0.1	0.5	0.5	0.5	-0.6	-0.1	0.1	0.1
Medication for cholesterol	0.3	0.5	1.7	0.3	0.9	0.7	1.0	0.4	0.9	0.4	0.6	0.5	0.1	0.6	1.3	-0.0
Hearing aid user	0.3	0.3	0.7	0.4	0.5	0.6	0.1	0.8	0.3	0.8	0.7	0.7	0.5	0.6	0.3	0.6
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	-0.6	-0.3	-0.4	0.1	-0.9	-0.3	-0.8	-0.6	-0.7	-1.0	-0.6	0.4	-0.5
Ever smoked	0.3	0.6	3.3	-0.8	-0.5	-0.5	-1.6	-0.3	-0.2	-0.4	-0.3	-0.4	-0.3	-0.5	-1.8	-0.3
Pain experienced in last month	0.3	0.6	1.3	0.9	0.4	0.4	0.4	0.7	0.4	0.7	0.6	0.6	1.1	0.8	1.1	1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	2.0	-0.2	-0.6	-0.8	-0.7	-0.3	-1.0	-0.1	-0.2	-0.2	0.2	-0.4	-1.4	0.2
Pack years of smoking	0.3	0.4	1.3	1.1	0.7	0.6	-0.3	0.4	0.5	0.4	0.4	0.3	0.5	0.6	-0.6	0.8
Alzheimer’s Disease (in father)	0.2	0.2	0.8	-0.3	0.5	0.4	0.9	0.0	0.6	0.0	0.2	0.2	-0.7	0.1	0.4	-0.3
Ovarian Cancer	0.2	0.2	0.6	-0.8	0.4	0.2	-0.5	0.2	0.4	0.1	0.2	0.2	-0.8	-0.0	0.3	-0.8
Age at First Birth	0.2	0.3	2.2	0.6	-0.0	0.0	0.2	-0.7	0.2	-0.4	-0.3	-0.5	0.1	0.2	1.5	-0.2
Coronary Artery Disease (CAD)	0.2	0.2	0.7	-0.4	-0.7	-0.6	-0.2	-0.4	-0.8	-0.5	-0.5	-0.3	-0.5	-0.5	0.0	-0.0
Rheumatoid Arthritis	0.2	0.2	1.0	-0.3	-0.2	-0.1	-1.0	-0.2	-0.1	-0.4	-0.3	-0.3	-0.8	-0.4	0.7	-0.6
Systolic Blood Pressure	0.2	1.1	6.3	-2.5	1.0	0.2	0.3	0.0	1.1	0.1	0.4	0.5	-1.9	-0.4	0.7	-1.0
Cardiovascular Disease	0.2	0.5	3.0	-0.5	-0.8	-0.7	-0.3	-0.7	-0.7	-0.6	-0.6	-0.7	-0.1	-0.6	-1.7	-0.4
Hair Pigment	0.2	5.5	22.0	2.3	1.1	2.0	2.5	1.8	1.8	2.0	1.9	1.8	2.3	2.1	4.7	2.3
Medication: Metformin	0.2	0.3	1.3	0.4	0.4	0.1	0.1	0.4	0.0	0.4	0.4	0.3	0.5	0.3	-1.1	1.1
Sitting height	0.2	1.7	2.9	0.1	1.6	1.4	0.2	1.3	1.6	1.6	1.7	1.6	0.5	1.1	1.0	1.6
Body mass index (BMI)	0.2	1.0	1.8	0.9	0.9	1.1	0.9	0.5	1.2	1.4	1.3	1.3	1.0	1.1	-0.1	0.4
Hair/balding pattern: Pattern 2	0.2	0.3	2.6	-0.6	-0.1	0.2	0.1	-0.3	0.4	0.0	0.2	0.2	-0.6	-0.1	1.6	-0.0
Had menopause	0.2	0.2	0.8	-0.4	0.6	0.6	0.4	0.5	0.6	0.3	0.4	0.4	-0.9	0.3	0.1	-0.4
Had other major operations	0.2	0.2	0.6	-0.5	0.5	0.3	0.1	-0.1	0.5	0.2	0.3	0.3	-0.7	0.1	-0.7	-0.6
Weight	0.2	1.2	2.4	0.6	1.1	1.4	0.5	0.6	1.5	1.5	1.6	1.5	0.6	1.1	-0.4	0.6
Loud music exposure frequency	0.2	0.2	0.7	-0.5	0.5	0.1	-0.9	0.2	0.2	0.3	0.4	0.4	-0.2	0.1	0.7	-0.3
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	1.1	0.1	-0.7	-0.4	-1.1	-0.8	-0.5	-0.6	-0.6	-0.6	0.1	-0.3	-0.9	0.7
Blood clot in the leg (DVT)	0.2	0.3	0.8	-0.0	0.2	0.5	0.5	0.3	0.6	0.6	0.7	0.7	0.1	0.4	-0.4	0.9
Wheeze or whistling in the chest in last year	0.2	0.4	1.6	-0.6	0.3	0.6	-0.2	0.4	0.8	0.7	0.9	0.8	-0.1	0.4	1.2	0.0
Shortness of breath walking on level ground	0.2	0.3	1.4	-1.2	0.2	0.2	-0.0	0.4	0.5	0.4	0.5	0.5	-0.7	-0.1	0.2	-0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	1.2	0.3	0.4	0.7	1.1	0.6	0.6	0.6	0.6	0.6	0.1	0.6	1.1	0.1
Migraine (self-reported)	0.2	0.3	1.1	-0.1	-0.6	-0.9	-0.5	0.1	-1.1	-0.3	-0.3	-0.3	0.7	-0.5	0.4	0.2
Whole body fat mass	0.2	1.0	3.0	-1.5	-0.7	-0.6	-0.6	-1.2	-0.4	-0.5	-0.4	-0.5	-1.4	-0.9	-1.4	-1.7
Had major operations	0.2	0.2	0.6	0.0	-0.5	-0.5	0.1	-0.6	-0.7	-0.6	-0.8	-0.7	-0.2	-0.5	-0.1	-0.1
Medication: Aspirin	0.2	0.3	1.2	-0.5	-0.4	-0.3	-0.2	-0.9	-0.2	-0.6	-0.5	-0.5	-1.1	-0.5	0.2	-0.3
Knee pain experienced in last month	0.2	0.3	2.2	0.8	-0.2	0.1	-0.4	0.1	-0.2	0.2	0.1	0.1	0.9	0.3	-1.5	-0.1
Average weekly red wine intake	0.2	0.3	1.5	0.5	0.4	0.1	0.3	0.3	0.3	0.4	0.4	0.4	0.8	0.4	0.4	1.2
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.7	0.8	-0.2	0.1	-0.1	-0.2	0.1	-0.0	-0.1	-0.1	0.3	0.2	-0.8	0.8
Commuting to job workplace: Public transport	0.2	0.3	0.8	-0.2	-0.4	-0.5	-0.4	-0.5	-0.7	-0.4	-0.7	-0.7	-0.4	-0.5	0.2	-0.9
Risk taking	0.2	0.3	1.3	-1.0	-0.5	-0.5	-0.2	-0.1	-0.4	-0.2	-0.1	-0.1	-0.5	-0.5	-1.1	-0.4
Fractured/broken bones in last 5 years	0.2	0.3	1.9	-0.5	0.5	0.1	0.4	0.5	0.2	0.4	0.4	0.4	-0.2	0.1	1.4	0.4
Vascular/heart problems diagnosed by doctor	0.2	0.4	2.8	0.6	0.7	0.5	0.3	0.4	0.6	0.4	0.4	0.4	0.3	0.6	1.7	0.2
Cholesterol lowering medication	0.2	0.4	2.9	0.5	-0.4	0.0	-0.8	0.4	-0.3	0.1	-0.0	-0.1	0.2	0.1	-1.7	0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	0.0	-0.7	-0.6	0.2	-0.6	-0.7	-0.5	-0.6	-0.6	0.1	-0.4	0.2	-0.1
Deep venous thrombosis (DVT) (self-reported)	0.2	0.2	0.9	-0.2	0.0	0.4	0.4	0.3	0.4	0.5	0.6	0.6	-0.0	0.2	-0.3	1.0
Alcohol drinker status: Previous	0.2	0.2	1.8	-0.1	-0.4	-0.1	-1.3	-0.3	-0.2	0.0	0.0	-0.0	0.1	-0.0	-1.0	0.2
Depressed Affect (Nagel 2018)	0.1	0.2	0.7	0.6	-0.3	-0.6	-0.6	-0.2	-0.9	-0.3	-0.4	-0.4	0.6	-0.2	-0.6	-0.2
Neuroticism (Nagel 2018)	0.1	0.2	0.6	0.8	0.0	-0.3	-0.4	0.3	-0.6	0.1	0.0	-0.0	0.7	0.1	-0.5	0.4
Schizophrenia (2018)	0.1	0.2	0.6	-0.7	-0.3	-0.2	-0.2	-0.0	-0.1	-0.3	-0.4	-0.3	-0.8	-0.3	-0.6	-0.8
Worry (Nagel 2018)	0.1	0.3	0.9	1.0	0.4	0.2	-0.1	0.6	0.1	0.4	0.4	0.3	0.7	0.5	-0.3	0.8
Breast Cancer	0.1	0.2	1.3	-0.6	0.2	0.1	0.8	-0.4	0.5	0.1	0.2	0.2	-0.5	0.1	0.2	-1.1
Prostate Cancer	0.1	0.2	0.5	0.2	-0.5	-0.3	0.7	-0.5	-0.5	-0.3	-0.4	-0.4	0.2	-0.2	-0.4	-0.2
Bipolar Disorder (2011)	0.1	0.1	0.3	-0.2	0.2	-0.1	0.0	0.3	-0.1	0.4	0.3	0.3	0.5	0.1	0.0	0.4
Schizophrenia (2014)	0.1	0.2	1.2	-0.4	-0.5	-0.4	-0.4	0.0	-0.4	-0.4	-0.5	-0.3	-0.3	-0.4	-1.1	-0.4
BMI	0.1	0.7	2.2	1.5	0.2	0.9	0.4	-0.2	0.9	0.8	0.8	0.7	1.2	0.9	-1.0	0.8
Height	0.1	1.5	2.9	-0.6	1.7	1.4	1.0	1.1	1.5	1.4	1.6	1.6	-0.6	0.8	-0.8	0.6
Smoking Status	0.1	0.3	1.7	-0.0	0.3	0.5	0.7	0.5	0.5	0.5	0.4	0.3	0.3	0.3	-1.3	-0.0
Neuroticism	0.1	0.2	1.4	1.2	0.6	0.3	-0.2	0.3	0.0	-0.2	-0.1	-0.0	0.5	0.4	0.2	-0.0
Sensitivity / hurt feelings	0.1	0.1	0.4	-0.1	-0.4	-0.3	0.7	0.1	-0.6	-0.1	-0.3	-0.2	-0.2	-0.3	-0.1	-0.7
Frequency of depressed mood in last 2 weeks	0.1	0.2	0.9	0.1	0.4	0.1	-0.5	0.5	0.1	0.4	0.4	0.3	0.2	0.2	0.8	0.9
Medication for hormone replacement therapy	0.1	0.1	0.3	-0.3	-0.3	-0.3	0.5	0.3	-0.3	0.1	-0.0	0.1	0.2	-0.3	-0.2	-0.3
Severe depression (siblings)	0.1	0.1	0.4	0.5	-0.1	0.3	0.6	0.3	0.1	0.1	-0.1	-0.2	0.3	0.3	-0.2	-0.0
Multivitamins +/- minerals	0.1	0.1	0.3	-0.3	-0.3	0.3	0.5	0.1	0.4	0.2	0.2	0.1	-0.1	0.1	0.3	-0.2
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	1.4	-0.2	0.3	0.1	0.0	0.2	0.1	0.1	0.2	0.2	-0.5	-0.0	1.2	-0.2
High blood pressure (mother)	0.1	0.2	0.6	0.0	0.4	0.6	0.7	-0.0	0.8	0.2	0.4	0.5	-0.1	0.4	0.4	0.4
Waist circumference	0.1	0.5	5.3	-0.1	-0.2	0.0	-0.5	-0.5	-0.0	0.2	0.1	-0.0	-0.2	-0.1	-2.3	-0.7
Number of incorrect matches in round	0.1	0.2	0.9	-0.9	-0.1	-0.1	-0.2	0.1	0.2	0.0	0.0	0.0	-0.7	-0.2	0.9	-0.7
Qualifications: None of the above	0.1	0.3	2.4	-0.9	0.1	-0.0	0.2	-0.0	0.2	0.1	0.2	0.2	-0.8	-0.3	-0.1	-1.5
Pain all over the body in last month	0.1	0.1	0.3	-0.3	-0.0	-0.5	-0.3	-0.3	-0.5	-0.3	-0.3	-0.4	-0.3	-0.5	-0.4	-0.2
Medication: Ramipril	0.1	0.1	0.4	0.4	-0.0	-0.1	-0.5	0.3	-0.3	0.2	0.1	0.1	0.6	0.2	-0.5	0.6
Neuroticism score	0.1	0.2	1.4	1.2	0.3	0.1	0.3	0.5	-0.3	0.2	0.1	0.0	0.7	0.3	0.1	0.2
Alcohol intake versus 10 years previously	0.1	0.2	0.5	0.3	-0.2	-0.2	-0.7	-0.4	-0.3	-0.7	-0.7	-0.7	-0.0	-0.3	0.2	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.1	0.1	0.4	-0.5	-0.6	-0.0	0.3	-0.2	0.1	-0.0	0.1	0.1	-0.3	-0.2	0.7	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.1	0.9	0.5	0.0	-0.1	-0.3	-0.3	-0.1	-0.3	-0.3	-0.4	0.4	-0.1	-1.0	0.3
Medication: Cholesterol lowering	0.1	0.2	0.7	-0.1	-0.4	-0.7	-0.4	-0.4	-0.9	-0.3	-0.3	-0.4	0.3	-0.5	-0.1	0.6
Arm fat mass (right)	0.1	0.5	1.1	0.3	0.6	0.9	0.8	0.1	1.0	1.0	1.0	0.9	0.3	0.7	-0.4	-0.1
Standing height	0.1	0.5	0.9	-0.3	0.8	0.8	-0.7	0.3	0.9	0.8	0.9	0.8	-0.5	0.4	-0.7	0.8
Tense / ‘highly strung’	0.1	0.1	0.7	0.7	0.3	0.0	-0.8	0.1	-0.1	-0.1	-0.0	-0.0	-0.0	0.1	-0.7	-0.4
Hair/balding pattern: Pattern 4	0.1	0.2	1.4	-0.6	0.2	-0.2	-1.2	-0.2	0.1	-0.2	0.0	0.1	-0.3	-0.2	-0.2	-0.4
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.5	-0.7	0.3	-0.1	0.1	0.4	0.1	0.3	0.4	0.4	-0.2	-0.0	0.5	0.1
Medication: Paracetamol	0.1	0.2	0.6	-0.3	-0.6	-0.7	-0.8	-0.2	-0.5	-0.4	-0.3	-0.3	0.3	-0.4	-0.1	0.2
Glaucoma (self-reported)	0.1	0.1	0.8	-0.3	0.1	0.0	0.2	-0.4	0.3	-0.2	-0.0	-0.1	-0.5	-0.1	0.9	0.1
Birth weight	0.1	0.3	1.2	-0.7	-0.2	-0.4	0.5	-0.5	-0.2	-0.4	-0.5	-0.4	-0.8	-0.5	-0.4	-1.1
Exposure to tobacco smoke outside home	0.1	0.1	0.4	0.0	-0.1	0.3	-0.6	0.5	0.4	0.4	0.4	0.3	0.2	0.3	-0.3	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.2	0.6	0.0	-0.6	-0.6	0.0	-0.2	-0.8	-0.4	-0.4	-0.4	0.2	-0.4	0.5	0.1
Qualifications: College or University degree	0.1	0.5	2.0	-0.4	-0.6	-0.5	-1.4	-0.4	-0.6	-0.5	-0.6	-0.5	-0.2	-0.4	-0.8	0.9
Emphysema/chronic bronchitis	0.1	0.1	0.3	0.3	-0.1	-0.1	0.1	0.4	-0.2	0.5	0.4	0.4	0.6	0.1	-0.0	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.1	0.1	0.6	0.4	0.0	0.2	0.6	0.4	0.1	0.2	0.2	0.3	0.2	0.1	0.1	0.8
Comparative height size at age 10	0.1	0.5	1.1	-0.3	0.9	0.9	0.5	0.4	1.0	0.8	0.9	0.8	-0.6	0.5	1.0	-0.1
Overall health rating	0.1	0.2	0.9	-0.5	-1.0	-0.4	-0.4	-0.5	-0.4	-0.3	-0.2	-0.2	-0.5	-0.5	-0.3	-0.4
Family relationship satisfaction	0.1	0.1	0.3	0.6	0.2	-0.0	-0.4	0.1	-0.2	-0.0	-0.0	-0.1	0.4	0.1	0.1	0.5
Arm fat percentage (left)	0.1	0.4	1.7	-0.9	-0.5	-0.3	0.2	-0.8	-0.1	-0.2	-0.2	-0.2	-0.7	-0.5	-1.1	-1.3
Handedness (chirality/laterality): Left-handed	0.1	0.2	0.7	0.9	-0.1	-0.2	-0.1	-0.4	-0.4	-0.5	-0.5	-0.6	0.3	-0.0	0.4	0.2
Medication: Aspirin	0.1	0.1	0.9	-0.2	0.2	0.3	0.4	-0.2	0.3	0.1	0.2	0.2	-0.5	0.0	1.0	0.3
Arm fat mass (left)	0.1	0.4	0.8	0.0	0.4	0.7	0.5	-0.1	0.9	0.8	0.8	0.8	0.1	0.4	-0.8	-0.3
Miserableness	0.1	0.2	1.6	0.7	-0.2	-0.2	-0.1	0.1	-0.5	0.0	-0.1	-0.2	0.6	-0.0	-1.3	-0.4
Guilty feelings	0.1	0.1	0.3	0.4	0.2	0.0	0.2	0.6	-0.2	0.3	0.4	0.2	0.5	0.2	0.6	-0.0
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.5	0.2	-0.5	-0.0	-0.0	-0.2	-0.1	-0.1	-0.1	-0.1	0.0	0.0	-0.7	-0.4
Medication: Paracetamol	0.1	0.2	0.7	0.3	-0.2	-0.2	-0.6	0.1	-0.0	-0.1	-0.0	0.1	0.8	0.0	0.8	0.8
Medication: Atorvastatin	0.1	0.1	0.5	-0.7	-0.2	-0.4	-0.5	0.1	-0.4	-0.1	-0.2	-0.3	-0.5	-0.5	-0.4	-0.1
Irritability	0.1	0.2	1.1	0.4	-0.1	-0.7	-0.2	0.2	-1.1	-0.2	-0.2	-0.2	0.6	-0.3	-0.7	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.9	-0.1	-0.0	-0.1	-0.5	-0.1	-0.2	-0.2	-0.2	-0.2	-0.3	-0.2	-1.0	0.2
Age started oral contraceptive pill	0.1	0.2	0.5	0.5	0.4	0.7	-0.0	-0.5	0.7	-0.1	0.1	0.0	-0.5	0.4	-0.2	-0.3
Diastolic blood pressure, automated reading	0.1	0.4	1.1	-0.8	-0.6	-0.8	-0.5	-0.6	-0.9	-0.5	-0.5	-0.5	-0.1	-0.6	-1.0	-0.5
Commuting to job workplace: Cycle	0.1	0.2	0.8	-0.2	-0.6	-0.5	-0.9	-0.2	-0.5	-0.2	-0.3	-0.2	0.2	-0.2	-0.5	0.1
Myopia	0.1	0.1	0.6	-0.3	0.0	0.1	0.2	0.6	0.1	0.5	0.4	0.4	0.1	0.2	-0.8	0.2
Supplements: Calcium	0.1	0.2	0.8	0.4	0.3	0.1	-0.1	0.2	0.1	0.5	0.4	0.5	0.5	0.3	-0.3	0.9
Heart disease (siblings)	0.1	0.2	0.8	0.5	-0.1	0.1	-0.6	0.5	-0.1	0.4	0.2	0.2	0.4	0.2	0.9	0.3
Tanning	0.0	0.4	2.3	-0.6	0.0	0.2	0.3	-0.3	0.3	0.0	0.1	0.1	-0.8	-0.0	1.1	-1.5
Medication: Co-codamol	0.0	0.0	0.1	-0.2	0.3	-0.2	0.1	-0.2	0.1	-0.0	0.1	0.0	-0.1	-0.2	-0.2	-0.0
Arm fat percentage (right)	0.0	0.2	0.6	-0.4	0.1	0.3	0.6	-0.3	0.6	0.4	0.4	0.4	-0.2	0.1	-0.5	-0.7
Illnesses of father: Heart disease	0.0	0.0	0.3	0.0	-0.0	-0.0	0.5	0.1	-0.1	0.2	0.1	0.1	0.2	-0.1	-0.1	0.1
Mineral and other dietary supplements	0.0	0.0	0.2	0.0	0.3	-0.0	0.0	0.5	-0.0	0.1	-0.0	0.0	0.2	0.0	0.3	0.4

Hub : Genes

FKBP10

Models

Trait associations