Hub : Genes

ACLY

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.058	0.0250	6.5e-03	0.031	0.008	0.011	0.027	0.022	1.0e-04	3.2e-02	1.3e-02	2.4e-04	8.7e-04
2	GTEx	Vagina	0.480	0.1210	6.0e-05	0.077	NA	0.223	NA	0.108	8.0e-03	NA	7.5e-06	NA	1.9e-03
3	YFS	Blood	0.047	0.0123	4.7e-12	0.046	0.039	0.047	0.044	0.047	8.3e-15	7.0e-13	4.4e-15	3.9e-14	4.4e-15
4	TCGA	Uterine Corpus Endometrial Carcinoma	0.118	0.0870	8.1e-03	-0.002	0.021	0.012	NA	0.003	3.7e-01	8.6e-02	1.4e-01	NA	2.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	0.7	1.1	1.8	0.8	-0.9	1.3	1.2
Bipolar Disorder or Schizophrenia	0.3	0.8	1.9	-0.3	-1.0	0.5	1.4
Depressed Affect (Nagel 2018)	1.1	2.4	4.8	2.2	1.5	1.5	-0.3
Depression (Nagel 2018)	0.3	0.5	0.8	0.7	-0.9	0.0	-0.7
Intelligence (Savage-Jansen 2018)	0.6	2.0	4.3	0.8	-0.6	1.6	2.1
Neuroticism (Nagel 2018)	0.8	1.8	4.6	2.1	0.3	1.5	-0.5
Schizophrenia (2018)	0.2	0.5	1.2	-1.1	-0.3	-0.5	0.8
Schizophrenia vs Biploar Disorder	0.5	0.7	1.7	0.3	0.7	-0.7	-1.3
Worry (Nagel 2018)	0.3	0.7	1.5	1.2	-0.4	0.7	-0.8
Alzheimer’s Disease (in mother)	1.0	1.1	3.5	-0.0	0.5	0.9	1.9
Alzheimer’s Disease (in father)	0.8	0.9	1.5	-1.1	-1.2	-0.9	0.1
Alzheimer’s Disease (including proxy)	0.7	1.0	3.0	-0.9	-0.4	-0.0	1.7
Crohns Disease (2017)	4.9	10.8	29.1	-2.2	-5.4	-3.0	0.4
Irritable Bowel Disease (IBD)	4.8	11.5	29.6	-2.5	-5.4	-3.2	0.1
Ulcerative Colitis (UC)	2.3	4.4	9.4	-1.7	-3.1	-2.2	-0.2
Major Depression (MDD)	4.1	5.0	8.1	-2.8	-2.1	-2.7	0.5
Reaction Time	1.5	2.9	4.3	2.1	1.7	2.1	-0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.3	3.1	0.5	-0.4	1.2	1.8
Breast Cancer	0.8	1.8	3.9	-2.0	-1.5	-1.0	0.3
Ovarian Cancer	1.2	1.6	4.1	-2.0	-0.2	-1.5	0.5
Prostate Cancer	0.4	0.5	1.3	1.1	0.1	0.9	-0.2
Age at First Birth	0.2	0.3	0.8	0.6	0.9	0.4	-0.2
Bipolar Disorder (2011)	0.5	0.5	1.6	0.1	-1.3	-0.1	-0.4
Body Mass Index (BMI) (2010)	0.7	1.0	2.1	-0.8	0.8	-1.4	-0.8
Coronary Artery Disease (CAD)	0.3	0.4	1.0	-0.4	1.0	0.6	0.3
Crohns Disease (2012)	4.0	6.5	13.7	-2.1	-3.7	-2.8	0.4
Mean Putamen Volume	0.8	0.9	2.8	0.1	-0.1	0.9	1.7
Fasting Glucose	3.2	3.9	7.1	-2.7	0.1	-2.5	1.4
HbA1C	0.4	0.5	0.6	-0.7	0.8	-0.5	0.8
HDL Cholesterol	0.2	0.4	0.8	-0.9	-0.4	0.1	0.8
LDL Cholesterol	2.3	3.6	5.2	2.3	2.2	2.1	0.2
Lupus	0.8	1.2	2.2	1.4	-0.7	1.5	-0.2
Neuroticism (2016)	1.3	1.8	3.8	-1.9	-0.3	-1.8	0.1
Primary Biliary Cirrhosis	0.4	0.6	1.2	0.3	1.1	0.9	0.7
Rheumatoid Arthritis	0.3	0.4	0.8	-0.5	-0.5	-0.2	0.9
Schizophrenia (2014)	0.0	0.0	0.0	0.1	0.2	0.2	0.2
Triglycerides	1.0	1.7	2.6	1.4	1.5	1.6	0.3
Type 2 Diabetes (T2D) (2012)	0.7	0.8	2.4	-0.3	-1.6	-0.7	-0.3
Ulcerative Colitis	1.2	1.8	3.1	-0.6	-1.4	-1.3	-1.7
Blood Eosinophil Count	1.5	11.5	23.2	-3.5	-1.3	-4.8	-2.9
Blood Platelet Count	0.4	4.4	13.7	-0.0	-1.5	1.3	3.7
Blood Red Count	0.4	3.9	11.7	-1.9	-0.3	0.2	3.4
Blood White Count	0.6	4.7	11.2	3.3	1.0	1.3	-2.2
Heel T-Score	1.8	14.6	44.1	2.8	6.6	1.2	-2.2
BMI	0.9	5.4	18.8	0.9	4.3	-0.1	-1.3
Height	0.2	3.6	7.3	-2.7	0.9	-2.5	0.1
Waist Hip Ratio (WHR)	4.3	19.2	30.9	4.9	4.5	5.6	1.3
Systolic Blood Pressure	2.6	12.8	19.7	-4.4	-3.9	-3.7	1.6
Smoking Status	0.2	0.4	0.8	-0.6	-0.7	-0.9	-0.1
Allergy or Eczema	0.5	1.4	4.3	0.1	-2.1	-0.9	-0.7
Cardiovascular Disease	0.8	2.5	9.5	0.2	3.1	0.7	0.2
Hypothyroidism (self reported)	0.8	1.9	3.6	-0.7	-0.3	-1.9	-1.8
Respiratory disease	1.2	2.6	5.4	0.4	-2.3	-1.1	-1.9
Type 2 Diabetes (T2D) (2018)	1.2	2.2	4.4	1.6	2.1	0.9	-1.0
Lung FEV1/FVC ratio	0.9	4.6	10.3	1.7	3.2	0.9	-2.1
Lung FVC	0.9	4.4	7.5	-2.7	-0.6	-2.7	-1.7
Neuroticism	0.5	1.2	2.7	1.6	1.2	0.9	-0.3
Chronotype (morning person)	1.8	4.1	8.8	1.8	1.8	3.0	1.0
Hair Pigment	0.1	2.2	6.3	-0.6	1.2	-0.9	-2.5
Tanning	0.1	1.8	4.0	-1.2	-2.0	-0.7	1.1
Hand grip strength (left)	0.7	1.9	4.3	-0.1	-0.6	-1.7	-2.1
Number of treatments/medications taken	0.1	0.2	0.5	0.7	0.0	0.6	0.2
Average weekly spirits intake	0.0	0.0	0.1	0.2	0.3	0.0	-0.1
Sensitivity / hurt feelings	0.3	0.5	1.1	1.0	-0.4	0.9	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.6	0.1	-1.6	-0.2	0.1
Hearing difficulty/problems: Yes	1.4	2.1	6.4	-0.4	-2.5	-1.3	-0.3
Relative age of first facial hair	1.2	2.4	5.1	2.2	-0.2	2.0	0.6
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.8	-0.8	-0.3	-0.9	-0.1
Ever used hormone-replacement therapy (HRT)	1.0	1.2	3.3	-1.8	-0.1	-1.2	0.4
Ever had hysterectomy (womb removed)	2.4	2.7	5.3	-2.3	-1.5	-1.3	1.3
Systolic blood pressure, automated reading	2.3	6.7	9.5	-3.1	-2.9	-3.0	0.4
Eye problems/disorders: Diabetes related eye disease	1.7	1.9	5.9	-0.1	-0.2	-1.3	-2.4
Angina	0.5	0.6	1.1	0.6	1.0	1.0	0.5
Medication for hormone replacement therapy	0.0	0.0	0.1	0.0	0.0	-0.4	0.0
Vitamin and mineral supplements	0.2	0.2	0.7	-0.1	0.4	0.0	-0.8
Supplements: Zinc	1.3	1.4	3.6	-1.0	-1.9	-1.1	0.3
Medication: Co-codamol	0.2	0.2	0.3	-0.6	0.2	-0.6	-0.3
Medication: Metformin	0.6	0.9	2.4	0.8	1.5	0.5	-0.5
Diabetes (father)	2.1	2.6	4.6	1.2	1.1	2.1	1.9
Diabetes (mother)	1.6	2.1	3.7	1.9	1.3	1.1	-1.2
Severe depression (siblings)	0.1	0.1	0.3	0.1	-0.2	0.5	-0.5
Pack years adult smoking proportion	0.7	1.1	2.4	1.6	0.7	0.8	-0.9
Impedance of leg (right)	3.0	14.7	40.5	-0.1	-2.3	3.6	6.4
Leg fat-free mass (left)	1.2	6.4	8.9	-1.1	2.7	-2.8	-3.0
Trunk fat percentage	0.9	3.5	7.4	-1.0	2.7	0.1	2.4
Hand grip strength (right)	0.6	1.7	2.7	-1.0	-1.6	-1.5	-0.9
Townsend deprivation index at recruitment	0.4	0.5	1.4	-0.7	-0.3	-0.3	1.2
Current tobacco smoking	0.3	0.6	0.9	-0.7	-0.8	-1.0	-0.5
Average weekly fortified wine intake	1.6	1.9	2.8	-1.7	-1.4	-1.6	0.6
Maternal smoking around birth	0.6	0.9	2.4	-1.0	0.2	-1.6	-0.3
Fed-up feelings	1.4	2.6	3.6	1.9	1.8	0.4	-1.9
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	0.6	-0.1	-0.4	-1.0
Relative age voice broke	0.0	0.0	0.1	-0.0	-0.4	-0.1	0.1
Taking other prescription medications	0.6	1.0	1.9	-0.4	-0.3	-1.4	-1.3
Age when periods started (menarche)	2.0	4.7	11.2	3.4	0.2	2.7	0.6
Bilateral oophorectomy (both ovaries removed)	0.9	1.0	2.2	-0.9	0.9	0.4	1.5
Heel bone mineral density (BMD) T-score, automated (left)	3.6	8.1	22.6	1.7	4.8	0.1	-2.6
Tinnitus: Yes, but not now, but have in the past	1.1	1.2	2.2	-0.6	-1.4	-0.2	1.5
Qualifications: CSEs or equivalent	0.8	1.1	2.6	-0.9	0.1	-1.6	-1.0
Serious illness, injury or assault to yourself	0.3	0.4	0.8	-0.0	0.8	-0.3	-0.9
High blood pressure	0.1	0.3	0.8	-0.1	0.7	0.3	0.9
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.8	0.0	-1.7	-1.1	-0.7
Multivitamins +/- minerals	0.3	0.3	0.6	-0.8	0.5	-0.6	0.4
Stomach or abdominal pain in last month	1.4	1.7	4.8	0.7	-2.2	0.9	0.9
Supplements: Glucosamine	0.4	0.5	1.1	-0.4	0.4	-1.1	-0.6
Diverticular disease/diverticulitis (self-reported)	0.5	0.6	1.8	-0.7	-1.3	-0.2	0.3
Medication: Atenolol	0.9	1.2	2.2	1.0	1.5	1.2	0.1
Medication: Levothyroxine sodium	1.0	1.7	5.0	1.0	0.1	-1.0	-2.2
Sitting height	0.4	2.6	4.4	-1.7	-1.6	-2.1	-0.5
Chronic bronchitis/emphysema (father)	1.6	1.8	3.2	-1.4	-1.4	-1.8	0.5
High blood pressure (mother)	0.6	0.8	1.4	-1.2	-0.6	-1.2	-0.2
Body mass index (BMI)	0.7	3.1	10.8	-0.2	3.3	-0.9	-1.0
Impedance of leg (left)	3.1	15.1	41.5	0.1	-1.8	4.0	6.4
Leg predicted mass (left)	1.2	6.4	8.5	-1.2	2.8	-2.8	-2.9
Trunk fat mass	0.8	3.2	9.9	-1.0	3.1	-0.4	1.4
Waist circumference	0.9	3.1	12.5	0.3	3.5	0.1	0.1
Number of incorrect matches in round	0.8	1.3	2.6	-1.6	-1.4	-0.8	0.5
Past tobacco smoking	0.1	0.2	0.3	-0.3	0.4	-0.6	-0.3
Alcohol usually taken with meals	0.9	1.5	2.4	0.4	-1.5	1.1	1.5
Nervous feelings	0.7	1.4	3.2	-0.3	-1.8	-1.1	-1.0
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.0	-0.2	-0.6	-1.0	-0.8
Hearing difficulty/problems with background noise	5.6	9.0	14.1	-2.8	-3.8	-3.7	-0.7
Hair/balding pattern: Pattern 2	1.6	2.0	5.3	-2.3	0.9	-1.3	0.5
Had menopause	1.3	1.6	3.8	-1.3	-1.9	-0.8	0.5
Had other major operations	1.1	1.3	3.1	-0.9	-1.8	-1.0	0.5
Forced vital capacity (FVC)	1.4	5.3	8.6	-2.4	-1.4	-2.9	-2.3
Heel bone mineral density (BMD) T-score, automated (right)	1.6	3.6	11.7	1.0	3.4	-0.2	-1.4
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.0	-0.4	-1.0	-0.8	-0.7
Qualifications: None of the above	0.6	1.3	2.5	-1.6	-0.8	-1.1	0.8
Financial difficulties in last 2 years	0.3	0.4	0.7	-0.7	0.4	-0.8	-0.4
Mouth/teeth dental problems	2.4	3.7	6.6	2.3	1.7	2.6	0.2
Heart attack	2.0	2.5	5.0	2.2	1.5	1.6	-0.6
Allergy	0.6	1.4	3.3	0.1	1.8	1.3	0.8
Pain all over the body in last month	0.2	0.2	0.3	0.6	0.2	0.5	0.2
Diabetes (self-reported)	2.1	3.2	6.1	1.9	2.5	0.9	-1.5
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	5.2	-1.2	-2.3	-1.6	0.2
Medication: Ramipril	0.8	1.0	2.1	1.4	1.1	0.8	-0.5
Medication: Simvastatin	2.2	3.2	4.2	2.0	2.0	2.1	-0.9
Fluid intelligence score	0.3	0.6	1.4	1.2	-0.1	1.0	0.5
Illnesses of siblings	0.8	1.1	2.0	1.0	-1.4	-0.3	-1.2
Neuroticism score	0.8	1.7	4.2	2.0	0.9	1.2	-0.6
Weight	0.8	3.8	11.0	-1.0	3.3	-1.6	-0.8
Impedance of arm (right)	0.8	3.8	7.2	-1.5	-2.4	0.1	2.7
Arm fat percentage (right)	0.6	2.2	6.5	-1.0	2.6	-1.1	0.1
Trunk fat-free mass	0.7	3.8	5.8	-0.7	2.2	-2.0	-2.4
Hip circumference	0.6	2.4	4.1	-1.8	1.4	-2.0	-0.5
Time employed in main current job	0.1	0.2	0.5	-0.0	0.3	-0.1	-0.7
Alcohol intake versus 10 years previously	0.4	0.6	1.3	0.7	1.1	0.8	0.3
Father’s age at death	0.3	0.4	0.9	0.5	-0.5	-0.1	-1.0
Worrier / anxious feelings	0.6	1.1	2.1	1.2	-0.7	0.5	-1.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.6	0.7	0.2	-0.1	-0.3
Falls in the last year	0.4	0.5	1.1	-0.0	1.1	-0.1	-0.9
Hair/balding pattern: Pattern 3	0.2	0.3	0.6	0.6	-0.1	-0.1	-0.8
Number of live births	0.7	1.0	3.0	0.2	-0.9	0.5	1.7
Forced expiratory volume in 1-second (FEV1)	1.2	4.2	8.0	-1.7	-0.2	-2.4	-2.8
Pulse rate	0.7	1.2	3.0	1.7	0.0	1.4	-0.2
Happiness	0.5	0.6	1.7	-0.2	0.6	-0.6	-1.3
Noisy workplace	2.5	3.1	7.7	-1.6	-0.9	-2.8	-1.2
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.5	0.4	0.5	0.8	1.6
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.4	-0.5	0.6	-0.5	0.2
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	0.5	-0.3	0.3	0.1
Asthma	1.7	3.4	9.7	-0.4	-3.1	-1.5	-1.3
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.2	0.6	0.8	0.3	0.4	-0.4
Medication: Cholesterol lowering	1.5	2.3	6.2	1.3	2.5	1.2	-0.4
Depression (self-reported)	0.9	1.1	2.2	1.2	0.5	1.5	0.6
Medication: Lansoprazole	0.7	0.8	2.9	0.5	0.2	1.7	0.0
Prospective memory result	0.7	0.9	2.9	-0.1	-0.2	-0.8	-1.7
Lung cancer (father)	0.3	0.3	1.0	-0.2	1.0	-0.2	-0.3
Illnesses of mother	3.8	4.6	8.6	2.9	1.6	2.6	-0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	7.6	-0.6	0.3	-1.1	-2.8
Pulse wave Arterial Stiffness index	0.7	0.9	1.8	1.4	0.3	1.1	0.5
Impedance of arm (left)	1.0	4.5	11.3	-1.2	-2.1	1.0	3.4
Arm fat mass (right)	0.8	3.3	10.5	-0.9	3.2	-1.2	-0.4
Trunk predicted mass	0.7	3.8	5.8	-0.7	2.2	-2.0	-2.4
Standing height	0.2	1.5	3.4	-1.9	0.4	-1.6	0.1
Length of working week for main job	0.4	0.5	1.1	-0.8	0.3	0.3	1.1
Exposure to tobacco smoke at home	0.9	1.0	2.6	-1.1	-0.3	0.3	1.6
Breastfed as a baby	1.6	2.0	3.6	0.9	1.2	1.5	1.9
Tense / ‘highly strung’	0.5	0.9	2.2	1.0	1.5	0.5	-0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	1.4	-0.3	-1.2	-0.4	-0.4
Hair/balding pattern: Pattern 4	0.2	0.6	1.1	-0.1	-1.0	-1.0	0.6
Birth weight of first child	0.1	0.2	0.5	0.2	-0.3	-0.5	-0.7
Peak expiratory flow (PEF)	0.6	1.5	5.2	-0.0	-0.2	-0.8	-2.3
Pulse wave reflection index	0.4	0.5	1.4	0.2	0.5	-0.5	-1.2
Ever highly irritable/argumentative for 2 days	0.3	0.3	0.6	-0.8	-0.3	-0.7	0.3
Loud music exposure frequency	1.0	1.0	2.6	-0.8	-1.6	-0.9	0.4
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.3	0.6	1.5	0.8	0.0
Mouth/teeth dental problems: Bleeding gums	1.7	2.2	5.3	-2.3	-0.5	-1.8	0.1
Blood clot in the leg (DVT)	0.4	0.5	0.7	-0.8	0.7	-0.7	-0.5
Medication: Paracetamol	0.4	0.6	2.3	0.4	-1.5	0.4	-0.0
Headache pain in last month	0.5	0.9	2.6	0.2	-0.8	0.6	1.6
Medication for cholesterol, blood pressure or diabetes	0.8	1.3	3.8	-0.4	-1.9	-0.7	-1.0
Glaucoma (self-reported)	0.4	0.5	0.7	-0.3	-0.8	-0.8	0.8
Gout (self-reported)	2.2	3.0	4.3	2.1	1.7	1.0	-1.9
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	4.5	-0.2	-0.3	-2.1	-2.1
Medication: Amlodipine	0.9	1.2	2.2	-1.5	-0.6	-1.5	-0.4
Medication: Ventolin 100micrograms inhaler	1.4	1.9	2.8	-1.0	-1.7	-1.6	-1.0
Birth weight	0.2	0.4	0.6	-0.4	-0.6	-0.6	0.8
Chronic bronchitis/emphysema (mother)	3.6	4.2	5.3	-2.3	-1.9	-1.8	2.1
High blood pressure (siblings)	0.7	1.1	2.2	-1.5	-0.1	-0.3	1.4
Forced vital capacity (FVC), Best measure	0.6	2.1	5.2	-1.0	-0.4	-1.4	-2.3
Body fat percentage	0.9	3.4	7.6	-0.9	2.8	0.1	2.3
Leg fat percentage (right)	1.2	4.2	9.8	-0.3	2.3	1.3	3.1
Arm fat-free mass (right)	0.5	2.6	6.8	-0.6	2.6	-1.3	-1.3
Exposure to tobacco smoke outside home	0.3	0.4	0.9	-1.0	0.8	-0.4	-0.1
Comparative body size at age 10	0.3	0.7	1.2	-0.8	0.4	-0.9	-1.1
Number of full brothers	1.1	1.4	2.9	0.4	0.7	1.7	1.4
Worry too long after embarrassment	0.9	1.4	3.4	0.8	-1.9	1.1	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.5	3.9	0.5	-2.0	-0.4	-1.2
Wheeze or whistling in the chest in last year	1.7	3.1	9.5	-1.1	-3.1	-1.3	0.0
Number of children fathered	3.2	3.6	10.3	-0.7	3.2	-1.1	-1.5
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.4	1.8	0.1	1.3	-0.1
Age at first live birth	0.8	1.4	3.7	0.9	0.9	-0.1	-1.9
Pulse wave peak to peak time	0.8	0.9	2.1	-1.5	-0.2	-1.1	-0.4
Health satisfaction	0.7	0.9	1.7	-0.4	-0.2	-1.3	-1.2
Shortness of breath walking on level ground	2.2	2.6	3.8	-1.8	-1.7	-1.9	0.6
Qualifications: College or University degree	0.0	0.1	0.3	-0.1	-0.4	0.5	-0.1
Eye problems/disorders: None of the above	2.2	2.6	5.4	-0.9	1.3	-1.5	-2.3
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.4	0.5	0.6	-0.6	-1.2
Emphysema/chronic bronchitis	0.5	0.5	0.6	0.8	0.8	0.7	-0.7
Medication for pain relief, constipation, heartburn	0.1	0.1	0.2	-0.4	0.3	-0.5	-0.2
Neck or shoulder pain in last month	0.4	0.6	1.4	-0.8	0.6	-0.1	1.2
Medication: Blood pressure	0.7	1.2	2.7	-0.1	1.6	0.4	1.5
Angina (self-reported)	0.3	0.4	0.9	0.3	0.9	0.7	0.4
Migraine (self-reported)	1.0	1.3	2.7	1.6	-0.9	1.1	-0.5
Medication: Ibuprofen	0.7	0.8	1.7	1.3	0.0	0.4	-1.1
Medication: Allopurinol	0.6	0.8	1.6	1.3	0.1	0.7	-1.0
Medication: Omeprazole	0.2	0.2	0.6	0.1	0.1	0.3	0.8
Medication: Seretide 50 evohaler	0.7	0.8	2.1	-1.0	-0.1	-1.4	-0.0
Mean time to correctly identify matches	1.2	2.2	3.2	1.8	1.6	1.7	-0.5
Heart disease (mother)	0.0	0.0	0.1	-0.0	0.2	0.3	0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.4	0.2	-1.2	0.3	-0.5
Whole body fat mass	0.7	3.0	9.3	-1.1	3.0	-0.5	1.2
Leg fat mass (right)	0.8	3.0	9.7	-0.5	3.1	0.2	1.4
Arm predicted mass (right)	0.6	3.1	8.3	-0.7	2.9	-1.5	-1.2
Pulse rate, automated reading	1.0	3.2	5.6	2.1	1.6	2.4	0.4
Alcohol intake frequency.	0.3	0.6	2.1	0.1	0.6	0.3	1.5
Comparative height size at age 10	0.4	2.3	5.1	-2.3	1.1	-1.7	0.5
Number of full sisters	1.3	1.6	3.7	-0.9	-1.9	-0.7	1.1
Suffer from ‘nerves’	0.6	1.0	2.5	-0.4	-0.6	-1.0	-1.6
Overall health rating	0.1	0.2	0.4	0.0	0.6	0.1	0.5
Chest pain or discomfort	1.5	2.1	6.4	-0.9	-2.5	-1.2	0.0
Had major operations	0.3	0.4	0.8	0.8	-0.0	0.9	0.5
Age at last live birth	2.5	3.7	6.1	2.5	2.1	1.8	-1.1
Family relationship satisfaction	0.3	0.4	0.8	0.6	0.9	0.5	-0.4
Leg pain on walking	0.6	0.7	2.3	0.0	0.3	-0.7	-1.5
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	-0.6	0.0	-1.0	-0.2
Commuting to job workplace: Car/motor vehicle	0.9	1.0	2.0	1.4	0.5	1.3	-0.1
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	6.9	-0.8	-2.6	-1.2	-0.4
Medication: Aspirin	0.6	0.8	2.1	-0.3	1.4	0.0	1.0
Supplements: Vitamin C	0.9	1.1	2.9	-0.2	-1.7	-1.1	-0.5
Knee pain experienced in last month	1.2	1.8	5.2	1.0	2.3	0.7	-0.8
Hypertension (Self-reported)	0.2	0.5	1.0	0.2	1.0	0.6	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.6	0.1	-0.1	0.5	0.8
Illnesses of father: Heart disease	0.4	0.5	1.2	0.6	1.1	0.5	-0.4
Illnesses of siblings: Diabetes	0.6	0.7	1.2	-0.2	1.1	1.0	0.8
Smoking status: Previous	0.3	0.4	0.8	0.8	0.0	0.9	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.2	-0.7	1.1	-0.6	-1.0
Whole body fat-free mass	0.9	4.9	6.9	-0.9	2.5	-2.3	-2.6
Leg fat-free mass (right)	1.2	6.7	10.6	-1.0	2.7	-2.8	-3.2
Arm fat percentage (left)	0.6	2.3	8.0	-0.8	2.8	-0.5	0.6
Average weekly red wine intake	0.2	0.3	0.4	-0.5	-0.4	-0.5	-0.6
Handedness (chirality/laterality): Left-handed	1.0	1.2	2.6	1.6	-0.7	1.3	-0.5
Mood swings	2.7	4.9	8.9	3.0	1.9	2.0	-1.7
Loneliness, isolation	0.8	1.2	2.4	-1.6	0.1	-0.3	1.4
Long-standing illness, disability or infirmity	0.8	1.2	2.4	-1.5	0.2	-1.6	0.2
Ever had bowel cancer screening	0.7	0.8	2.1	-0.7	-1.5	-0.6	0.5
Diabetes diagnosed by doctor	1.4	2.2	4.3	1.5	2.1	0.8	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.7	0.8	0.7	0.5	-0.4
Friendships satisfaction	3.3	4.1	8.4	-2.5	0.0	-2.9	-1.3
Qualifications: nursing, teaching	0.1	0.2	0.4	0.1	0.4	0.5	0.7
Commuting to job workplace: Walk	0.5	0.5	2.1	-0.2	-0.1	0.2	1.4
Eye problems/disorders: Cataract	2.6	3.0	7.6	-0.4	-1.8	0.9	2.8
Mouth/teeth dental problems: Mouth ulcers	2.6	4.1	7.1	-2.2	-2.0	-2.7	-0.4
Medication for cholesterol	0.3	0.5	0.8	-0.7	-0.8	-0.9	-0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.3	2.7	4.4	1.9	1.3	2.1	1.1
Back pain experienced in last month	0.3	0.4	0.9	-0.1	-1.0	0.5	0.7
Mineral and other dietary supplements	0.0	0.1	0.1	-0.1	0.3	0.3	-0.1
Breast cancer (self-reported)	1.9	2.3	4.6	-2.1	-1.6	-1.3	-0.7
Asthma (self-reported)	1.7	3.5	9.6	-0.3	-3.1	-1.5	-1.4
Osteoporosis (self-reported)	1.5	1.9	2.8	-1.5	-1.7	-1.1	1.0
Osteoarthritis (self-reported)	2.7	3.5	6.5	-1.0	1.2	-2.3	-2.5
Medication: Aspirin	0.4	0.5	1.5	-0.5	1.2	-0.3	0.5
Medication: Gliclazide	0.5	0.6	1.4	-0.2	1.2	-0.6	-0.8
Illnesses of father: None of the above (group 1)	0.9	1.2	2.3	1.1	1.5	1.1	-0.0
Smoking status: Current	0.4	0.7	1.3	-0.9	-0.8	-1.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	6.4	0.5	1.0	-0.2	-2.5
Whole body water mass	0.9	5.0	7.3	-0.8	2.6	-2.3	-2.7
Leg predicted mass (right)	1.3	6.8	11.0	-1.0	2.7	-2.8	-3.3
Arm fat mass (left)	0.8	3.1	10.2	-1.0	3.2	-1.1	-0.2
Number of self-reported non-cancer illnesses	0.3	0.6	1.4	0.5	-0.6	0.7	1.2
Average weekly champagne plus white wine intake	0.7	1.0	2.9	-0.8	-0.0	0.7	1.7
Miserableness	1.2	2.1	4.5	2.1	1.4	1.3	-0.5
Guilty feelings	0.4	0.6	1.6	0.7	-1.3	0.6	-0.3
Wears glasses or contact lenses	0.4	0.4	1.6	0.1	-0.2	0.4	1.3
Ever taken oral contraceptive pill	0.3	0.3	0.8	-0.2	-0.3	-0.9	-0.6
Hearing aid user	0.3	0.3	1.0	0.2	1.0	-0.0	-0.4
Mother’s age at death	2.0	2.5	4.5	-1.8	-1.1	-2.1	-1.1
Financial situation satisfaction	0.5	0.6	1.0	-0.7	1.0	-0.7	-0.6
Tinnitus: Yes, now most or all of the time	1.5	1.7	3.7	-1.3	-1.0	-1.9	-0.7
Commuting to job workplace: Public transport	0.5	0.6	1.0	0.7	0.4	0.8	1.0
Eye problems/disorders: Glaucoma	0.4	0.5	1.9	0.0	-0.1	0.0	1.4
Medication: Blood pressure	0.2	0.5	1.7	-0.2	-0.2	0.3	1.3
Pain type(s) experienced in last month: Hip pain	0.7	0.9	2.7	0.7	-0.5	-0.1	-1.6
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.2	0.5	0.3	-0.1	-0.1
High cholesterol (Self-reported)	3.1	5.4	8.8	2.2	2.9	3.0	-0.0
Medication: Bendroflumethiazide	1.3	2.0	3.4	0.1	1.8	1.2	1.8
Medication: Paracetamol	0.6	0.9	3.0	0.2	-1.7	0.3	-0.5
Medication: Lisinopril	1.2	1.6	5.6	-0.3	0.1	0.7	2.4
Medication: Atorvastatin	0.2	0.2	0.3	-0.6	0.4	0.1	0.5
Illnesses of father: High blood pressure	0.4	0.5	0.7	0.3	-0.8	0.7	0.8
Alcohol drinker status: Never	0.7	0.9	3.0	-0.7	-0.2	0.0	1.7
Ever smoked	0.8	1.4	5.2	-0.5	-2.3	-0.4	0.3
Basal metabolic rate	0.8	4.6	8.3	-1.0	2.9	-2.2	-2.1
Leg fat percentage (left)	1.2	4.3	9.1	-0.3	2.5	1.3	3.0
Arm fat-free mass (left)	0.7	3.6	5.8	-1.1	2.4	-2.1	-1.7
Number of operations (self-reported)	2.5	3.7	8.8	-0.8	-3.0	-0.0	2.3
Average weekly beer plus cider intake	0.9	1.3	2.9	0.1	1.4	-0.3	-1.7
Irritability	2.8	4.7	11.1	2.2	3.3	1.6	-0.5
Risk taking	0.2	0.3	0.6	-0.8	0.3	-0.4	0.4
Ever had prostate specific antigen (PSA) test	0.1	0.2	0.3	0.5	0.5	0.3	-0.1
Fractured/broken bones in last 5 years	0.5	0.6	1.8	-1.4	-0.3	-0.6	0.1
Age started oral contraceptive pill	0.5	0.6	1.4	-1.2	0.8	-0.4	0.1
Diastolic blood pressure, automated reading	0.1	0.3	0.6	0.1	0.7	0.8	0.1
Ever depressed for a whole week	2.9	3.6	7.1	-1.9	-2.7	-2.0	0.3
Unable to work because of sickness or disability	1.3	1.7	5.2	0.3	1.0	-0.7	-2.3
Commuting to job workplace: Cycle	0.1	0.2	0.5	-0.0	-0.7	0.4	-0.1
Myopia	0.1	0.1	0.3	-0.3	-0.1	-0.6	0.2
Vascular/heart problems diagnosed by doctor	0.1	0.4	1.3	-0.3	-1.1	-0.4	-0.2
Cholesterol lowering medication	0.5	0.7	1.5	0.3	1.2	0.9	-0.6
Medication: Omeprazole (e.g. Zanprol)	0.2	0.3	0.6	0.1	0.3	0.7	0.8
Pain experienced in last month	0.1	0.2	0.9	0.2	0.1	-0.1	-0.9
Supplements: Calcium	0.9	1.0	2.0	1.2	-1.4	0.2	-0.8
Basal cell carcinoma (self-reported)	0.4	0.4	1.0	1.0	0.1	0.8	0.2
Heart attack/myocardial infarction (self-reported)	1.2	1.6	3.1	1.8	1.2	1.3	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.0	-0.7	1.0	-0.5	-0.4
Heart disease (siblings)	0.7	0.9	2.3	0.5	1.5	0.8	-0.6
Alcohol drinker status: Previous	1.8	2.0	7.7	-0.3	2.8	0.5	-0.1
Pack years of smoking	0.8	1.2	2.7	1.6	0.8	0.8	-0.9
Impedance of whole body	1.8	9.3	25.4	-0.8	-2.4	2.3	5.0
Leg fat mass (left)	0.8	3.2	10.4	-0.6	3.2	0.1	1.4
Arm predicted mass (left)	0.7	3.5	6.5	-1.0	2.5	-2.0	-1.6