Best TWAS P=5.15e-29 · Best GWAS P=1.37e-24 conditioned to 0.694
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Visceral Omentum | RP11-332H18.4 | 0.22 | 0.07 | lasso | 7 | 0.05 | 9.0e-04 | 7.0 | 8.9 | 5.3e-19 | 0.89 | 0.01 | 0.98 | FALSE |
| 2 | GTEx | Artery Tibial | TBX2 | 0.21 | 0.03 | enet | 37 | 0.06 | 1.4e-05 | 7.0 | 5.5 | 4.9e-08 | 0.49 | 0.20 | 0.74 | FALSE |
| 3 | GTEx | Artery Tibial | RP11-332H18.4 | 0.18 | 0.15 | lasso | 1 | 0.14 | 4.5e-11 | 7.0 | 7.0 | 3.4e-12 | 0.70 | 0.96 | 0.04 | FALSE |
| 4 | GTEx | Brain Frontal Cortex BA9 | RP11-332H18.4 | 0.40 | 0.05 | lasso | 16 | 0.07 | 6.4e-03 | 5.8 | 5.4 | 6.2e-08 | 0.31 | 0.05 | 0.58 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | RP11-332H18.4 | 0.19 | 0.16 | lasso | 4 | 0.14 | 1.7e-10 | 7.0 | 7.6 | 3.4e-14 | 0.76 | 0.43 | 0.57 | FALSE |
| 6 | GTEx | Esophagus Mucosa | RP11-332H18.4 | 0.19 | 0.09 | lasso | 4 | 0.04 | 9.6e-04 | 7.0 | 7.4 | 1.6e-13 | 0.73 | 0.04 | 0.95 | FALSE |
| 7 | GTEx | Lung | RP11-332H18.4 | 0.10 | 0.04 | enet | 3 | 0.07 | 6.8e-06 | 7.0 | 6.3 | 3.1e-10 | 0.65 | 0.05 | 0.93 | FALSE |
| 8 | GTEx | Testis | TBX2 | 0.20 | 0.18 | lasso | 3 | 0.15 | 4.8e-07 | 7.0 | 7.1 | 1.5e-12 | 0.70 | 0.51 | 0.44 | FALSE |
| 9 | GTEx | Testis | RP11-332H18.4 | 0.19 | 0.19 | lasso | 2 | 0.16 | 1.6e-07 | 7.1 | 7.5 | 4.2e-14 | 0.73 | 0.34 | 0.65 | FALSE |
| 10 | GTEx | Thyroid | TBX2 | 0.10 | 0.09 | lasso | 2 | 0.06 | 1.7e-05 | 7.0 | 7.0 | 2.9e-12 | 0.71 | 0.09 | 0.90 | FALSE |
| 11 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | C17orf82 | 0.03 | 0.02 | blup | 42 | 0.00 | 1.3e-01 | 10.2 | -11.2 | 5.1e-29 | -0.90 | 0.00 | 0.96 | TRUE |
| 12 | The Cancer Genome Atlas | Skin Cutaneous Melanoma | C17orf82 | 0.13 | 0.01 | enet | 5 | 0.03 | 5.0e-02 | 6.7 | 7.4 | 1.7e-13 | 0.23 | 0.02 | 0.06 | FALSE |