Best TWAS P=4.66e-10 · Best GWAS P=1.16e-09 conditioned to 1
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | CD79B | 0.15 | 0.16 | enet | 9 | 0.17 | 3.5e-14 | 6.0 | -6.1 | 1.4e-09 | -0.98 | 0.00 | 1.00 | FALSE |
2 | GTEx | Adipose Visceral Omentum | CD79B | 0.15 | 0.00 | lasso | 6 | 0.02 | 4.1e-02 | 6.0 | -5.6 | 2.2e-08 | -0.89 | 0.01 | 0.95 | FALSE |
3 | GTEx | Breast Mammary Tissue (Female) | CD79B | 0.04 | 0.07 | lasso | 2 | 0.03 | 4.2e-02 | 4.9 | -5.1 | 2.7e-07 | -0.70 | 0.03 | 0.45 | FALSE |
4 | GTEx | Cells Transformed fibroblasts | PSMC5 | 0.19 | 0.09 | lasso | 5 | 0.10 | 7.1e-08 | 5.1 | 5.2 | 2.1e-07 | 0.68 | 0.14 | 0.86 | FALSE |
5 | GTEx | Esophagus Mucosa | STRADA | 0.05 | 0.07 | lasso | 2 | 0.05 | 1.9e-04 | 5.2 | 5.2 | 1.8e-07 | 0.74 | 0.12 | 0.61 | FALSE |
6 | GTEx | Esophagus Muscularis | PSMC5 | 0.12 | 0.08 | lasso | 3 | 0.07 | 3.8e-05 | 5.4 | 5.2 | 1.7e-07 | 0.74 | 0.13 | 0.75 | FALSE |
7 | GTEx | Testis | CCDC47 | 0.17 | 0.06 | enet | 28 | 0.09 | 1.0e-04 | 5.4 | -6.1 | 8.3e-10 | -0.68 | 0.02 | 0.96 | FALSE |
8 | METSIM | Adipose | CD79B | 0.04 | 0.01 | lasso | 5 | 0.01 | 4.3e-03 | 4.6 | -5.8 | 7.8e-09 | -0.56 | 0.03 | 0.91 | FALSE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CD79B | 0.02 | 0.02 | lasso | 2 | 0.01 | 3.0e-03 | 6.1 | -6.2 | 4.7e-10 | -0.99 | 0.00 | 0.93 | TRUE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SCN4A | 0.04 | 0.01 | blup | 39 | 0.03 | 1.4e-07 | 6.1 | 5.6 | 2.0e-08 | 0.74 | 0.00 | 1.00 | FALSE |
11 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STRADA | 0.07 | 0.01 | blup | 57 | 0.03 | 5.5e-04 | -3.6 | -5.1 | 3.0e-07 | -0.70 | 0.01 | 0.86 | FALSE |
12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | STRADA | 0.03 | 0.00 | blup | 57 | 0.01 | 5.2e-02 | 5.1 | -5.2 | 1.7e-07 | -0.73 | 0.00 | 0.76 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | PSMC5 | 0.04 | 0.03 | lasso | 1 | 0.03 | 5.6e-04 | 5.4 | 5.4 | 8.0e-08 | 0.76 | 0.00 | 0.96 | FALSE |