Best TWAS P=7.4e-10 · Best GWAS P=5.3e-09 conditioned to 0.198
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LRRC45 | 0.09 | 0.10 | enet | 7 | 0.10 | 1.2e-11 | 5.7 | -5.8 | 7.5e-09 | -0.61 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | LRRC45 | 0.23 | 0.06 | lasso | 3 | 0.05 | 1.0e-04 | 5.7 | -5.8 | 5.9e-09 | -0.64 | 0.01 | 0.99 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | LRRC45 | 0.18 | 0.03 | enet | 12 | 0.10 | 9.0e-06 | 5.7 | -5.1 | 2.8e-07 | -0.73 | 0.02 | 0.98 | FALSE |
| 4 | GTEx | Artery Tibial | LRRC45 | 0.09 | 0.07 | lasso | 4 | 0.04 | 2.0e-04 | 5.7 | -6.1 | 8.3e-10 | -0.71 | 0.01 | 0.99 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | LRRC45 | 0.08 | 0.08 | enet | 3 | 0.08 | 2.6e-06 | 5.7 | -5.8 | 6.3e-09 | -0.70 | 0.01 | 0.99 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | LRRC45 | 0.19 | 0.06 | enet | 9 | 0.12 | 6.7e-06 | 5.5 | -6.2 | 7.4e-10 | -0.83 | 0.01 | 0.98 | TRUE |
| 7 | GTEx | Nerve Tibial | DCXR | 0.19 | 0.06 | enet | 20 | 0.10 | 1.4e-07 | -2.5 | -5.2 | 1.5e-07 | -0.25 | 0.80 | 0.09 | FALSE |
| 8 | GTEx | Thyroid | ASPSCR1 | 0.23 | 0.15 | enet | 19 | 0.09 | 1.2e-07 | 5.8 | -5.2 | 1.5e-07 | -0.94 | 0.00 | 1.00 | FALSE |
| 9 | YFS | Blood | ASPSCR1 | 0.11 | 0.07 | lasso | 9 | 0.06 | 7.9e-20 | 5.6 | -5.7 | 1.0e-08 | -0.85 | 0.00 | 1.00 | FALSE |
| 10 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LRRC45 | 0.02 | 0.03 | blup | 36 | 0.02 | 1.5e-03 | 5.7 | -6.0 | 1.6e-09 | -0.64 | 0.00 | 0.91 | FALSE |
| 11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PYCR1 | 0.02 | 0.01 | blup | 9 | 0.01 | 1.1e-02 | 4.9 | -5.8 | 8.3e-09 | -0.86 | 0.00 | 0.52 | FALSE |
| 12 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LRRC45 | 0.05 | 0.07 | lasso | 6 | 0.06 | 9.5e-08 | 5.7 | -5.7 | 1.2e-08 | -0.69 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MYADML2 | 0.03 | 0.03 | blup | 10 | 0.03 | 1.1e-04 | 5.7 | 5.7 | 1.3e-08 | 0.83 | 0.01 | 0.94 | FALSE |
| 14 | The Cancer Genome Atlas | Lung Adenocarcinoma | NPB | 0.03 | 0.01 | enet | 3 | 0.01 | 1.1e-02 | 5.5 | -5.4 | 8.1e-08 | -0.85 | 0.00 | 0.83 | FALSE |
| 15 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LRRC45 | 0.10 | 0.02 | blup | 35 | 0.04 | 8.0e-03 | 4.1 | -5.7 | 1.1e-08 | -0.72 | 0.01 | 0.45 | FALSE |
| 16 | The Cancer Genome Atlas | Prostate Adenocarcinoma | STRA13 | 0.05 | 0.03 | lasso | 3 | 0.02 | 1.8e-03 | 5.7 | -5.7 | 1.1e-08 | -0.63 | 0.00 | 0.97 | FALSE |