Best TWAS P=4.87e-11 · Best GWAS P=4.45e-11 conditioned to 0.263
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | TOM1 | 0.09 | 0.06 | lasso | 4 | 0.05 | 4.4e-05 | 5.7 | 6.3 | 2.8e-10 | 0.96 | 0.02 | 0.98 | FALSE |
| 2 | GTEx | Muscle Skeletal | TOM1 | 0.16 | 0.13 | lasso | 15 | 0.11 | 3.1e-11 | 6.5 | 6.6 | 5.7e-11 | 0.99 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Spleen | TOM1 | 0.57 | 0.14 | lasso | 12 | 0.08 | 4.3e-03 | 5.4 | 6.1 | 1.4e-09 | 0.82 | 0.02 | 0.92 | FALSE |
| 4 | NTR | Blood | TOM1 | 0.05 | 0.05 | lasso | 5 | 0.06 | 2.3e-17 | 6.5 | 6.6 | 4.9e-11 | 0.95 | 0.02 | 0.98 | TRUE |
| 5 | YFS | Blood | TOM1 | 0.13 | 0.23 | lasso | 10 | 0.24 | 3.1e-77 | 5.7 | 6.4 | 1.2e-10 | 0.91 | 0.55 | 0.45 | FALSE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HMGXB4 | 0.01 | 0.01 | blup | 59 | 0.01 | 8.3e-03 | 6.5 | 6.4 | 1.9e-10 | 0.97 | 0.02 | 0.84 | FALSE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | HMGXB4 | 0.05 | 0.03 | blup | 59 | 0.03 | 7.1e-03 | 3.4 | 6.0 | 2.3e-09 | 0.89 | 0.02 | 0.41 | FALSE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | TOM1 | 0.03 | 0.03 | blup | 65 | 0.02 | 1.7e-03 | 6.3 | 5.6 | 2.3e-08 | 0.89 | 0.02 | 0.80 | FALSE |