TWAS hub - TOM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0170	2.9e-03	0.024	0.019	0.033	0.020	0.022	6.2e-04	2.1e-03	6.3e-05	1.5e-03	1.0e-03
2	GTEx	Adipose Subcutaneous	0.0900	0.0370	2.2e-03	0.062	NA	0.035	NA	0.052	7.8e-06	NA	6.5e-04	NA	4.4e-05
3	GTEx	Muscle Skeletal	0.1644	0.0361	1.6e-10	0.126	NA	0.099	NA	0.114	2.3e-12	NA	5.8e-10	NA	3.1e-11
4	GTEx	Spleen	0.5730	0.1160	1.8e-04	0.138	NA	-0.006	NA	0.081	2.2e-04	NA	5.0e-01	NA	4.3e-03
5	NTR	Blood	0.0517	0.0126	1.1e-11	0.050	0.041	0.047	0.048	0.056	9.1e-16	2.8e-13	5.8e-15	2.9e-15	2.3e-17
6	YFS	Blood	0.1301	0.0193	0.0e+00	0.228	0.211	0.235	0.235	0.239	5.8e-73	3.3e-67	1.1e-75	1.7e-75	3.1e-77
7	TCGA	Thyroid Carcinoma	0.0260	0.0160	4.6e-03	0.026	0.025	0.011	NA	0.021	1.2e-03	1.7e-03	2.8e-02	NA	3.3e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Ulcerative Colitis (UC)	11.7	22.0	26.6	-4.1	-4.6	-4.8	-4.8	-5.0	-5.2	-4.2
Irritable Bowel Disease (IBD)	8.2	19.6	21.6	-4.1	-4.3	-4.7	-4.6	-4.5	-4.5	-4.3
Waist Hip Ratio (WHR)	8.2	36.8	43.2	4.7	6.3	6.6	6.1	6.6	6.4	5.6
Diabetes (mother)	7.5	9.5	14.8	2.7	3.2	3.2	3.2	2.8	2.4	3.9
LDL Cholesterol	7.3	11.5	13.6	3.0	3.4	3.6	3.3	3.6	3.7	3.1
Alcohol drinker status: Previous	6.1	7.0	10.0	2.3	2.7	2.5	3.2	2.7	2.7	2.4
Hip circumference	5.8	25.1	30.7	-3.7	-5.4	-5.5	-4.9	-5.2	-4.8	-5.3
Ulcerative Colitis	5.6	8.1	10.0	-1.7	-3.0	-2.8	-2.8	-3.0	-3.2	-3.1
Hayfever/allergic rhinitis (self-reported)	4.4	5.8	7.3	-1.7	-2.5	-2.7	-2.4	-2.7	-2.7	-2.1
Chronotype (morning person)	4.3	9.9	12.5	-2.2	-3.2	-3.4	-3.5	-3.3	-3.3	-2.9
Number of full sisters	4.3	5.2	6.6	-2.3	-2.3	-2.6	-2.0	-2.4	-2.2	-2.1
Age at last live birth	4.2	6.0	9.7	1.8	2.4	2.5	2.4	2.6	2.3	3.1
Reaction Time	4.1	7.8	11.7	-2.6	-2.6	-2.8	-2.7	-2.8	-2.5	-3.4
Cardiovascular Disease	4.1	13.6	15.9	2.8	3.9	3.8	4.0	3.8	3.9	3.4
Average weekly red wine intake	4.1	6.1	8.8	2.3	1.5	2.0	2.9	2.5	2.6	3.0
Lung cancer (father)	3.9	4.5	6.9	1.4	2.2	2.2	2.6	2.2	2.1	2.0
Hayfever, allergic rhinitis or eczema	3.7	8.1	10.6	-1.0	-3.2	-3.1	-3.0	-2.9	-2.8	-3.3
Medication: Ibuprofen (e.g. Nurofen)	3.7	4.7	6.7	1.2	2.3	2.3	2.4	2.6	2.5	1.6
Alcohol drinker status: Never	3.6	4.4	6.4	-0.9	-1.8	-2.1	-2.5	-2.4	-2.4	-2.0
Primary Biliary Cirrhosis	3.3	4.8	7.9	-2.8	-2.3	-2.4	-1.8	-1.9	-1.8	-2.2
Height	3.3	63.4	72.8	-6.7	-8.2	-8.5	-7.3	-8.3	-8.1	-8.5
Alcohol intake frequency.	3.2	7.4	11.7	0.1	3.4	2.8	3.2	2.9	3.0	2.0
Blood Platelet Count	3.1	35.4	43.0	4.0	6.6	6.4	6.4	6.3	6.1	5.4
Sitting height	2.9	20.5	25.1	-3.5	-4.7	-5.0	-4.0	-4.9	-4.8	-4.5
Mean time to correctly identify matches	2.9	5.5	10.0	-1.9	-2.1	-2.2	-2.3	-2.4	-2.1	-3.2
Alcohol intake versus 10 years previously	2.8	4.1	5.5	2.3	2.0	2.1	2.3	2.0	2.2	0.8
Medication: Ibuprofen	2.8	3.3	4.6	1.1	2.0	2.0	1.9	2.1	2.0	1.2
Medication: Atenolol	2.7	3.4	5.2	-0.1	1.9	1.8	2.3	2.1	2.3	1.5
Allergy	2.7	6.1	10.9	1.1	2.7	2.7	2.5	2.3	2.2	3.3
Supplements: Vitamin C	2.6	3.1	4.5	2.1	1.9	2.0	1.4	1.5	1.5	1.8
Arm predicted mass (left)	2.5	12.7	17.5	-2.2	-4.2	-4.2	-2.9	-3.9	-3.5	-3.7
Allergy or Eczema	2.4	6.4	9.0	-0.7	-3.0	-2.8	-2.7	-2.6	-2.6	-2.6
Back pain experienced in last month	2.4	3.4	7.1	-1.5	-2.7	-2.4	-1.0	-1.6	-1.3	-1.9
Fasting Glucose	2.3	2.7	3.6	1.7	1.2	1.4	1.6	1.7	1.8	1.9
Lupus	2.3	3.5	6.7	0.3	1.8	1.6	2.6	2.1	2.5	1.1
Weight	2.3	11.2	14.8	-2.4	-3.8	-3.9	-2.9	-3.4	-3.0	-3.7
Length of working week for main job	2.2	2.4	7.0	2.6	0.9	1.4	1.4	1.4	1.5	0.9
Type 2 Diabetes (T2D) (2012)	2.1	2.4	4.2	2.1	1.6	1.6	1.0	1.4	1.3	1.6
Leg fat-free mass (left)	2.1	11.0	15.3	-2.4	-3.9	-3.8	-2.7	-3.5	-3.2	-3.2
Leg predicted mass (left)	2.1	11.2	15.5	-2.4	-3.9	-3.9	-2.8	-3.6	-3.3	-3.3
Peak expiratory flow (PEF)	2.1	4.9	7.1	1.2	2.4	2.3	1.9	2.4	2.3	2.7
Qualifications: NVQ or HND or HNC or equivalent	2.1	2.5	4.5	2.1	1.0	1.4	1.6	1.6	1.7	1.4
Whole body fat-free mass	2.1	11.9	16.2	-2.4	-4.0	-4.0	-2.7	-3.7	-3.4	-3.5
Leg fat-free mass (right)	2.1	11.4	16.3	-2.6	-4.0	-3.9	-2.7	-3.6	-3.3	-3.2
Basal metabolic rate	2.1	11.6	16.0	-2.4	-4.0	-4.0	-2.7	-3.6	-3.3	-3.6
Arm fat-free mass (left)	2.1	10.5	14.6	-2.1	-3.8	-3.8	-2.4	-3.5	-3.1	-3.5
Age started oral contraceptive pill	2.1	2.7	6.5	2.5	1.3	1.8	1.6	1.4	1.3	1.1
Rheumatoid Arthritis	2.0	2.7	4.2	-0.7	-2.1	-1.9	-1.1	-1.7	-1.5	-2.1
Birth weight	2.0	4.3	7.4	-1.6	-2.7	-2.2	-2.2	-2.2	-2.0	-1.1
Loneliness, isolation	2.0	2.8	5.4	1.6	1.8	1.8	2.3	1.6	1.6	0.6
Whole body water mass	2.0	11.2	15.4	-2.3	-3.9	-3.9	-2.6	-3.6	-3.3	-3.4
Leg predicted mass (right)	2.0	10.6	15.5	-2.5	-3.9	-3.8	-2.6	-3.5	-3.1	-3.1
Triglycerides	1.9	3.1	4.4	0.3	2.1	1.9	1.5	2.1	2.1	1.5
Forced vital capacity (FVC), Best measure	1.9	7.0	9.0	-1.6	-3.0	-2.9	-2.5	-2.9	-3.0	-2.3
Irritability	1.9	3.2	5.3	1.0	2.1	2.3	1.3	2.1	1.9	1.3
Diverticular disease/diverticulitis (self-reported)	1.8	2.1	2.7	0.8	1.6	1.5	1.6	1.6	1.4	1.5
Trunk fat-free mass	1.8	10.3	13.6	-2.1	-3.7	-3.7	-2.6	-3.5	-3.3	-3.2
Standing height	1.8	18.2	21.6	-2.9	-4.7	-4.6	-4.0	-4.6	-4.5	-4.3
Medication: Amlodipine	1.8	2.5	6.9	2.6	1.4	1.7	0.8	1.1	1.0	1.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.8	2.2	3.1	0.5	1.6	1.7	1.2	1.6	1.6	1.6
Lung FEV1/FVC ratio	1.7	8.8	11.2	1.8	3.0	3.0	3.2	3.3	3.3	2.8
Trunk predicted mass	1.7	9.9	13.1	-2.1	-3.6	-3.6	-2.5	-3.5	-3.3	-3.1
Commuting to job workplace: Car/motor vehicle	1.7	2.0	2.7	1.5	1.2	1.5	1.5	1.6	1.6	0.7
Tinnitus: Yes, now most or all of the time	1.7	2.0	6.9	2.6	1.0	1.3	0.8	1.1	1.1	1.1
Risk taking	1.7	2.5	4.5	2.1	1.2	1.6	0.9	1.8	1.9	1.1
Crohns Disease (2017)	1.6	3.6	4.6	-2.1	-1.9	-2.1	-1.9	-1.6	-1.5	-2.0
Coronary Artery Disease (CAD)	1.6	1.9	5.2	1.2	0.8	1.2	0.9	1.3	1.3	2.3
Worrier / anxious feelings	1.6	3.1	4.1	1.1	1.9	2.0	1.4	1.8	1.8	2.0
Asthma	1.6	3.2	5.0	-0.7	-1.8	-1.8	-1.5	-1.9	-2.0	-2.2
Prostate Cancer	1.5	2.1	3.9	0.4	-2.0	-1.6	-1.5	-1.5	-1.4	-1.2
Hair Pigment	1.5	44.1	54.7	5.3	7.1	7.4	6.8	6.9	6.6	6.2
Hair/balding pattern: Pattern 3	1.5	2.3	3.7	-1.1	-1.6	-1.4	-1.9	-1.4	-1.6	-1.3
Arm fat-free mass (right)	1.5	7.6	10.7	-1.7	-3.3	-3.3	-1.9	-3.0	-2.7	-3.0
Knee pain experienced in last month	1.5	2.3	2.8	1.5	1.6	1.7	1.4	1.6	1.5	1.2
Maternal smoking around birth	1.4	2.1	2.7	1.5	0.9	1.4	1.4	1.6	1.6	1.5
Falls in the last year	1.4	2.0	2.8	0.9	1.4	1.5	1.3	1.5	1.5	1.7
Illnesses of mother	1.4	1.7	3.3	-1.0	-1.0	-1.1	-1.3	-1.4	-1.3	-1.8
Wheeze or whistling in the chest in last year	1.4	2.6	3.5	1.4	1.7	1.7	1.9	1.5	1.6	1.5
Emphysema/chronic bronchitis	1.4	1.5	2.2	1.4	1.5	1.4	0.4	1.1	1.1	1.4
Mouth/teeth dental problems: Mouth ulcers	1.4	2.2	6.5	2.5	0.8	1.2	1.2	1.3	1.3	1.1
Average weekly champagne plus white wine intake	1.4	2.0	2.7	-0.9	-1.3	-1.3	-1.6	-1.5	-1.5	-1.5
Medication: Lisinopril	1.4	1.8	2.4	1.5	1.2	1.4	1.3	1.3	1.2	1.5
Body Mass Index (BMI) (2010)	1.3	1.8	2.5	-1.4	-1.6	-1.6	-1.0	-1.3	-1.2	-1.3
Shortness of breath walking on level ground	1.3	1.5	2.8	0.8	1.2	1.2	1.7	1.5	1.5	0.3
Arm predicted mass (right)	1.3	6.6	9.6	-1.6	-3.1	-3.1	-1.7	-2.9	-2.5	-2.6
Handedness (chirality/laterality): Left-handed	1.3	1.6	3.1	-1.6	-1.2	-1.2	-1.8	-1.0	-1.0	-1.0
Asthma (self-reported)	1.3	2.5	4.4	-0.3	-1.6	-1.5	-1.5	-1.7	-1.8	-2.1
Ever taken oral contraceptive pill	1.3	1.5	4.2	2.1	1.0	1.2	0.7	0.8	0.6	1.5
Pain type(s) experienced in last month: Hip pain	1.3	1.7	3.9	2.0	0.3	0.6	1.8	1.1	1.1	1.2
High cholesterol (Self-reported)	1.3	2.3	3.3	0.8	1.8	1.7	1.7	1.5	1.4	1.3
Fractured/broken bones in last 5 years	1.3	1.7	2.2	-1.3	-0.9	-1.1	-1.3	-1.5	-1.5	-1.5
Major Depression (MDD)	1.2	1.4	2.3	0.0	1.5	1.4	1.3	1.4	1.4	0.6
Respiratory disease	1.2	2.6	4.4	0.3	-1.7	-1.5	-1.7	-1.6	-1.7	-2.1
Type 2 Diabetes (T2D) (2018)	1.2	2.2	4.8	1.4	1.2	1.4	2.2	1.3	1.3	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.2	1.6	3.7	-0.5	1.9	1.4	1.1	1.1	0.9	1.3
Diabetes diagnosed by doctor	1.2	2.0	4.3	1.2	1.2	1.3	2.1	1.3	1.5	1.0
Basal cell carcinoma (self-reported)	1.2	1.4	2.2	0.9	1.5	1.5	0.6	1.1	0.8	1.5
Tanning	1.1	13.2	15.1	3.6	3.7	3.7	3.5	3.8	3.9	3.4
Medication: Metformin	1.1	1.5	3.6	1.0	1.0	1.0	1.9	1.2	1.4	0.6
Diabetes (father)	1.1	1.4	2.4	0.5	1.4	1.1	1.4	1.2	1.6	0.8
Number of live births	1.1	1.5	2.6	-0.5	-1.0	-1.0	-1.6	-1.5	-1.6	-1.0
Friendships satisfaction	1.1	1.3	2.7	-1.6	-0.8	-1.1	-0.7	-0.9	-0.8	-1.7
Osteoporosis (self-reported)	1.1	1.4	4.3	-2.1	-0.4	-1.0	-1.3	-0.9	-1.1	-0.7
Hand grip strength (left)	1.0	2.7	4.1	-0.9	-1.8	-1.8	-1.3	-2.0	-1.9	-1.4
Frequency of tenseness / restlessness in last 2 weeks	1.0	1.6	2.4	-0.0	1.6	1.4	1.3	1.3	1.2	1.4
Forced expiratory volume in 1-second (FEV1), Best measure	1.0	3.2	4.8	-1.0	-2.2	-2.0	-1.6	-2.0	-2.0	-1.5
Arm fat mass (right)	1.0	4.1	6.0	-1.1	-2.5	-2.5	-1.9	-2.1	-1.7	-2.2
Gout (self-reported)	1.0	1.4	1.8	-0.9	-1.2	-1.3	-0.5	-1.3	-1.3	-1.3
Chronic bronchitis/emphysema (mother)	1.0	1.2	2.3	0.5	1.2	1.2	0.4	1.2	1.2	1.5
Average weekly fortified wine intake	0.9	1.1	2.2	-1.2	-0.9	-1.2	-1.5	-0.9	-1.0	-0.5
Trunk fat mass	0.9	4.0	6.3	-1.3	-2.3	-2.4	-1.7	-1.9	-1.5	-2.5
Happiness	0.9	1.1	2.6	-1.6	-0.7	-0.8	-0.4	-1.0	-1.0	-1.3
Age at first live birth	0.9	1.5	2.4	0.5	1.0	1.0	1.6	1.4	1.3	1.5
Neck or shoulder pain in last month	0.9	1.2	2.7	1.6	0.7	1.0	1.1	1.1	1.0	1.0
Hypertension (Self-reported)	0.9	2.5	3.8	2.0	1.4	1.4	1.4	1.5	1.6	1.5
Illnesses of father: Heart disease	0.9	1.2	3.4	0.5	1.2	1.1	1.9	1.1	1.0	0.3
Arm fat mass (left)	0.9	3.7	5.6	-0.9	-2.4	-2.3	-1.7	-2.0	-1.6	-2.1
Medication: Bendroflumethiazide	0.9	1.4	2.5	0.6	1.0	1.1	1.6	1.3	1.4	1.1
Heart attack/myocardial infarction (self-reported)	0.9	1.1	3.0	-1.7	-0.4	-1.1	-0.5	-0.7	-0.4	-1.7
Vitamin and mineral supplements	0.8	1.0	1.7	-0.3	-1.0	-0.9	-1.3	-1.2	-1.2	-0.9
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	1.3	1.1	0.8	1.1	0.8	0.9	0.9	0.7
Forced vital capacity (FVC)	0.8	2.9	4.3	-1.3	-1.8	-1.8	-1.9	-1.9	-2.1	-1.3
Heart attack	0.8	1.0	3.0	-1.7	-0.3	-1.0	-0.4	-0.5	-0.2	-1.5
Diabetes (self-reported)	0.8	1.3	3.0	1.0	1.1	1.0	1.7	1.0	1.1	0.5
Father’s age at death	0.8	1.0	2.6	-0.2	-0.9	-0.9	-1.6	-1.1	-1.2	-0.5
Medication: Cholesterol lowering	0.8	1.3	1.9	1.1	1.4	1.4	1.1	1.0	0.8	1.1
Birth weight of first child	0.8	1.5	3.7	-0.5	-1.9	-1.4	-1.1	-0.9	-0.9	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.8	1.0	1.5	-0.7	-0.9	-1.0	-0.9	-1.2	-1.2	-1.1
Whole body fat mass	0.8	3.3	5.1	-1.0	-2.3	-2.3	-1.5	-1.8	-1.4	-2.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.7	0.7	1.2	1.3	0.6	1.0	0.9	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.8	1.6	1.1	0.8	1.1	0.7	0.6	0.5	1.3
Ever depressed for a whole week	0.8	1.0	2.3	-0.6	-0.2	-0.6	-1.4	-0.9	-0.9	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	1.9	-0.5	1.2	0.7	1.4	1.2	1.2	0.5
Pack years of smoking	0.8	1.2	2.5	-0.6	-1.6	-1.4	-0.9	-1.2	-0.9	-0.8
HbA1C	0.7	0.8	2.2	1.5	0.2	0.9	0.4	1.0	1.0	0.7
Chronic bronchitis/emphysema (father)	0.7	0.9	1.6	-0.8	1.0	0.7	0.9	0.8	0.9	1.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.2	1.6	-0.8	-1.1	-1.0	-1.2	-1.1	-1.3	-0.9
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.8	0.4	-1.1	-0.9	-1.2	-0.8	-0.6	-1.3
Blood clot in the leg (DVT)	0.7	0.9	1.8	-0.3	1.1	0.7	1.3	1.1	1.1	0.4
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.5	-1.1	-1.1	-1.1	-0.3	-0.9	-0.7	-1.9
Number of children fathered	0.7	0.8	4.0	2.0	-0.4	-0.1	-0.1	-0.1	-0.1	1.0
Mother’s age at death	0.7	0.8	2.8	-1.7	-0.6	-0.8	-0.6	-0.6	-0.6	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.7	0.9	1.5	1.1	1.2	1.2	0.2	0.9	0.8	0.9
Blood Red Count	0.6	5.6	7.2	-1.8	-2.4	-2.7	-2.3	-2.7	-2.3	-2.2
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.5	-1.0	-0.6	-0.7	-1.1	-1.0	-1.2	-0.3
Severe depression (siblings)	0.6	0.7	1.5	-1.2	-0.9	-1.0	-0.5	-0.9	-0.7	0.2
Pack years adult smoking proportion	0.6	0.9	1.9	-0.7	-1.4	-1.2	-0.7	-1.0	-0.7	-0.6
Impedance of leg (left)	0.6	2.7	4.2	1.3	2.0	1.9	1.3	1.8	1.8	1.1
Waist circumference	0.6	2.2	5.0	-1.0	-1.7	-1.7	-1.2	-1.2	-0.9	-2.2
Neuroticism score	0.6	1.3	2.6	0.2	1.4	1.3	1.6	1.2	1.2	0.3
Hair/balding pattern: Pattern 4	0.6	1.4	2.8	0.8	1.1	1.2	1.4	0.9	0.9	1.7
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.4	1.5	0.5	0.6	0.4	0.2	-0.0	1.4
Long-standing illness, disability or infirmity	0.6	0.9	1.8	-1.3	-0.7	-1.1	-0.8	-1.0	-1.0	-0.6
Qualifications: nursing, teaching	0.6	1.0	2.3	0.6	0.5	0.8	1.1	1.0	0.9	1.5
Breast cancer (self-reported)	0.6	0.7	1.7	-1.3	-0.8	-1.0	-0.6	-0.6	-0.6	-0.8
Miserableness	0.6	1.0	3.6	0.6	1.0	0.9	1.9	0.7	0.6	-0.3
Medication: Blood pressure	0.6	1.1	2.3	0.6	0.8	0.9	1.5	1.2	1.4	0.7
Leg fat mass (left)	0.6	2.5	4.0	-0.9	-1.9	-1.9	-1.2	-1.5	-1.1	-2.0
Schizophrenia (2018)	0.5	1.1	1.7	1.0	0.6	0.9	1.3	1.1	1.2	1.1
Verbal and Numeric Reasoning (VNR)	0.5	1.3	1.5	-1.2	-1.1	-1.2	-1.2	-1.1	-1.1	-1.1
Bipolar Disorder (2011)	0.5	0.5	1.4	-1.2	-0.5	-0.8	0.0	-0.7	-0.6	0.0
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.3	-0.1	1.1	0.9	1.0	0.9	0.9	0.8
Medication for hormone replacement therapy	0.5	0.6	2.2	-1.1	-0.1	-0.3	-1.5	-0.6	-0.6	-0.0
Impedance of leg (right)	0.5	2.4	4.6	1.2	2.2	1.9	0.9	1.7	1.6	0.9
Trunk fat percentage	0.5	2.0	4.0	-0.9	-1.6	-1.7	-1.3	-1.2	-0.8	-2.0
Age when periods started (menarche)	0.5	1.2	2.0	0.0	1.4	1.4	0.8	1.4	1.3	0.7
High blood pressure	0.5	1.4	3.6	1.9	1.1	1.0	1.0	1.0	1.1	1.0
Body mass index (BMI)	0.5	2.3	3.5	-1.0	-1.8	-1.9	-1.2	-1.5	-1.1	-1.8
Mouth/teeth dental problems: Dentures	0.5	0.8	1.7	-1.3	-0.6	-1.0	-0.7	-0.9	-1.0	-0.6
Exposure to tobacco smoke at home	0.5	0.5	1.7	-1.2	-0.0	-0.1	0.6	0.0	0.3	-1.3
Exposure to tobacco smoke outside home	0.5	0.6	1.7	0.8	0.5	0.7	1.3	0.7	0.9	-0.4
Medication: Allopurinol	0.5	0.7	1.2	-0.1	-1.1	-1.1	-0.4	-1.1	-0.9	-0.6
Medication: Omeprazole	0.5	0.6	1.6	1.3	0.8	1.0	0.0	0.6	0.6	0.7
Leg fat mass (right)	0.5	2.0	3.4	-0.8	-1.7	-1.8	-1.1	-1.3	-0.9	-1.8
Overall health rating	0.5	1.0	1.6	0.2	1.2	0.9	1.2	1.0	1.1	1.1
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.5	1.2	0.6	0.7	0.3	0.8	0.9	0.5
Smoking status: Previous	0.5	0.7	2.5	0.5	-1.6	-1.0	-0.3	-0.5	-0.5	-0.7
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.5	-0.9	-1.2	-1.1	-0.7	-1.1	-1.0	-0.8
Mood swings	0.5	1.0	1.6	0.9	1.2	1.2	1.3	0.8	0.5	0.8
Commuting to job workplace: Walk	0.5	0.5	1.4	-0.6	-0.1	-0.6	-1.2	-0.8	-0.9	0.0
Wears glasses or contact lenses	0.5	0.6	1.1	1.1	0.4	0.8	0.2	0.7	0.7	1.0
Illnesses of father: High blood pressure	0.5	0.6	1.6	-0.9	0.8	0.4	0.5	0.5	0.6	1.3
Unable to work because of sickness or disability	0.5	0.6	1.6	0.2	1.3	1.0	0.5	0.5	0.2	0.9
Depression (Nagel 2018)	0.4	0.6	1.5	-0.1	1.2	0.8	0.9	0.6	0.5	0.8
Age at First Birth	0.4	0.5	1.6	-0.4	-1.3	-0.9	-0.5	-0.5	-0.5	-0.7
Crohns Disease (2012)	0.4	0.7	1.4	-1.2	-0.7	-0.9	-0.9	-0.5	-0.5	-0.9
Neuroticism	0.4	0.8	1.9	-0.9	1.0	0.9	1.4	0.8	0.8	-0.2
Relative age of first facial hair	0.4	0.8	2.6	-0.1	-0.9	-0.6	-1.6	-0.5	-0.6	-1.0
Systolic blood pressure, automated reading	0.4	1.2	1.8	-1.3	-0.4	-1.0	-1.2	-1.3	-1.2	-0.7
Angina	0.4	0.6	1.6	-0.4	-0.7	-0.6	-1.3	-0.7	-0.8	-0.5
Hand grip strength (right)	0.4	1.1	1.7	-0.9	-0.9	-1.1	-1.1	-1.3	-1.3	-0.5
Relative age voice broke	0.4	0.6	1.4	0.7	-0.8	-0.4	-0.9	-0.5	-0.6	-1.2
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	0.9	-1.0	-0.2	-0.5	-0.7	-0.8	-0.7	-0.4
Serious illness, injury or assault to yourself	0.4	0.5	0.7	-0.5	0.8	0.7	0.9	0.6	0.5	0.8
Stomach or abdominal pain in last month	0.4	0.5	1.1	0.3	1.0	0.9	0.7	0.6	0.3	0.8
High blood pressure (mother)	0.4	0.6	1.0	-0.1	0.9	0.5	1.0	0.8	0.8	0.7
Number of incorrect matches in round	0.4	0.6	1.6	0.1	0.5	0.5	1.3	0.9	1.0	-0.5
Hair/balding pattern: Pattern 2	0.4	0.5	1.3	0.4	0.5	0.5	1.1	0.8	0.8	0.3
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.4	-0.7	0.5	-0.0	-1.2	-0.5	-0.5	-0.8
Pulse rate	0.4	0.7	1.7	1.1	0.5	0.6	0.5	0.9	0.8	1.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.8	-1.3	-0.6	-0.7	-0.4	-0.4	-0.3	-0.6
Depression (self-reported)	0.4	0.5	2.2	-1.5	-0.3	-0.4	-0.1	-0.4	-0.5	0.5
Prospective memory result	0.4	0.5	0.8	0.8	-0.5	-0.5	-0.2	-0.9	-0.8	-0.7
Loud music exposure frequency	0.4	0.4	2.7	1.6	-0.4	0.0	0.4	0.0	0.0	0.1
Medication: Paracetamol	0.4	0.6	2.1	0.2	-0.7	-0.7	-0.7	-0.5	-0.5	-1.5
Migraine (self-reported)	0.4	0.5	0.7	0.5	0.8	0.8	0.9	0.8	0.6	0.4
Family relationship satisfaction	0.4	0.5	1.0	0.5	0.9	1.0	1.0	0.7	0.4	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.5	1.2	0.6	-1.1	-0.6	-0.5	-0.8	-0.6	0.2
Medication: Gliclazide	0.4	0.4	1.1	-0.7	0.7	0.3	1.1	0.6	0.7	0.1
Guilty feelings	0.4	0.6	3.0	-1.7	0.3	0.1	0.4	0.2	-0.1	-0.9
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.3	-1.5	-0.8	-0.9	-0.9	-1.0	-1.1	-0.7
Cholesterol lowering medication	0.4	0.6	1.2	0.4	0.8	0.9	0.8	1.1	1.0	0.0
Supplements: Calcium	0.4	0.4	1.8	0.2	0.6	0.6	0.2	0.6	0.1	1.4
Alzheimer’s Disease (in father)	0.3	0.3	1.3	-0.9	0.0	-0.4	-0.2	-0.2	-0.1	-1.1
Mean Putamen Volume	0.3	0.4	0.6	-0.5	-0.7	-0.6	-0.7	-0.5	-0.7	-0.5
Schizophrenia (2014)	0.3	0.7	1.4	0.8	0.6	0.9	1.2	0.8	0.8	0.7
Hearing difficulty/problems: Yes	0.3	0.5	1.5	-0.0	-1.2	-0.9	-0.3	-0.6	-0.4	-0.8
Ever used hormone-replacement therapy (HRT)	0.3	0.4	1.5	-0.4	-0.2	-0.1	-1.2	-0.6	-0.8	0.1
Supplements: Zinc	0.3	0.3	1.8	-1.3	0.3	0.0	0.2	0.3	0.4	-0.3
Current tobacco smoking	0.3	0.5	1.7	-1.3	-0.1	-0.4	-1.0	-0.5	-0.6	0.1
Fed-up feelings	0.3	0.6	1.0	-1.0	-0.6	-0.7	-0.1	-0.7	-0.7	-1.0
Past tobacco smoking	0.3	0.6	1.8	-0.8	1.3	0.9	0.4	0.5	0.5	0.4
Alcohol usually taken with meals	0.3	0.5	2.3	1.5	-0.1	0.3	-0.1	-0.1	-0.2	0.9
Had menopause	0.3	0.3	1.0	-0.1	-0.4	-0.3	-1.0	-0.6	-0.7	-0.4
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	1.4	-1.2	-0.9	-0.8	-0.7	-0.4	-0.3	-0.9
Qualifications: None of the above	0.3	0.6	1.3	-1.0	-0.4	-0.6	-0.7	-0.7	-0.4	-1.1
Medication: Ramipril	0.3	0.4	1.5	-1.2	-0.3	-0.4	-0.4	-0.3	-0.3	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	1.0	-0.7	-0.4	-0.7	-0.5	-0.8	-1.0	-0.5
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.6	0.3	0.8	0.7	0.7	0.6	0.7	0.4
Hypothyroidism/myxoedema (self-reported)	0.3	0.7	1.3	-0.6	-0.9	-0.8	-0.6	-1.1	-1.1	0.1
Body fat percentage	0.3	1.2	2.6	-0.5	-1.3	-1.3	-0.9	-0.9	-0.5	-1.6
Pulse wave peak to peak time	0.3	0.3	1.0	-0.5	-0.6	-0.6	-1.0	-0.4	-0.4	-0.1
Heart disease (mother)	0.3	0.4	0.8	0.5	-0.7	-0.4	-0.9	-0.5	-0.6	0.6
Suffer from ‘nerves’	0.3	0.5	2.4	-0.8	-0.4	-0.4	0.1	-0.5	-0.4	-1.5
Chest pain or discomfort	0.3	0.4	0.9	-0.0	0.1	0.5	0.9	0.7	0.9	0.7
Leg pain on walking	0.3	0.4	1.4	-1.2	-0.4	-0.7	-0.6	-0.3	-0.2	-0.7
Medication for cholesterol	0.3	0.5	1.1	-0.2	-0.7	-0.8	-0.6	-1.0	-1.1	-0.3
Commuting to job workplace: Public transport	0.3	0.3	0.5	-0.4	-0.7	-0.7	-0.1	-0.7	-0.7	-0.4
Eye problems/disorders: Glaucoma	0.3	0.3	1.0	1.0	-0.1	0.1	0.9	0.4	0.5	-0.2
Medication: Paracetamol	0.3	0.4	1.7	-0.4	-0.3	-0.5	-0.5	-0.5	-0.5	-1.3
Myopia	0.3	0.4	0.8	0.4	0.3	0.7	0.9	0.8	0.6	0.6
Pain experienced in last month	0.3	0.5	2.9	-1.7	-0.0	-0.2	-0.5	-0.3	-0.2	-0.1
Heart disease (siblings)	0.3	0.4	1.3	-0.5	-0.8	-0.8	0.2	-0.2	0.2	-1.2
Impedance of whole body	0.3	1.5	2.8	0.7	1.7	1.6	0.4	1.4	1.2	1.0
Bipolar Disorder (2018)	0.2	0.3	0.5	-0.5	-0.7	-0.7	-0.6	-0.5	-0.4	-0.6
Depressed Affect (Nagel 2018)	0.2	0.5	1.7	0.1	0.9	0.7	1.3	0.3	0.1	-0.5
Intelligence (Savage-Jansen 2018)	0.2	0.6	3.1	-1.8	-0.2	-0.5	-0.7	-0.4	-0.5	-0.3
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	0.8	-0.0	0.3	0.3	0.5	0.5	0.4
HDL Cholesterol	0.2	0.4	1.9	1.4	0.2	0.4	0.7	0.2	0.1	0.1
BMI	0.2	1.3	2.1	-1.0	-1.1	-1.3	-1.0	-1.1	-0.8	-1.4
Hypothyroidism (self reported)	0.2	0.5	1.0	-0.6	-0.7	-0.6	-0.4	-1.0	-1.0	0.0
Lung FVC	0.2	1.2	2.1	-0.6	-1.0	-1.0	-1.4	-1.2	-1.4	-0.7
Average weekly spirits intake	0.2	0.3	0.6	0.8	-0.3	-0.3	-0.8	-0.4	-0.5	-0.4
Sensitivity / hurt feelings	0.2	0.4	2.1	-1.4	-0.1	-0.5	-0.2	-0.4	-0.4	-0.4
Eye problems/disorders: Diabetes related eye disease	0.2	0.3	0.6	-0.0	0.3	0.3	0.8	0.5	0.5	0.8
Medication: Co-codamol	0.2	0.2	0.4	0.6	0.5	0.3	-0.1	0.2	0.4	0.6
Townsend deprivation index at recruitment	0.2	0.3	0.7	-0.2	0.8	0.7	-0.1	0.5	0.5	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	2.7	-1.6	-0.0	-0.2	-0.2	0.1	0.2	-0.2
Nervous feelings	0.2	0.4	1.5	-1.0	-0.0	-0.4	-0.2	-0.2	-0.0	-1.2
Hearing difficulty/problems with background noise	0.2	0.3	0.6	-0.4	0.5	0.4	0.6	0.4	0.7	0.8
Had other major operations	0.2	0.2	0.5	0.6	0.3	0.5	0.3	0.4	0.3	0.7
Pain all over the body in last month	0.2	0.2	0.8	0.9	0.3	0.3	0.3	-0.1	-0.1	0.5
Arm fat percentage (right)	0.2	1.0	1.7	-0.4	-1.3	-1.3	-1.0	-0.9	-0.6	-1.1
Time employed in main current job	0.2	0.2	0.7	-0.8	-0.1	-0.3	-0.2	-0.7	-0.6	0.2
Forced expiratory volume in 1-second (FEV1)	0.2	0.7	1.1	-0.7	-0.8	-0.8	-1.1	-0.9	-1.1	-0.3
Noisy workplace	0.2	0.2	0.6	0.1	-0.8	-0.7	0.3	0.0	0.2	-0.5
Medication: Lansoprazole	0.2	0.3	0.7	0.4	-0.2	-0.2	-0.9	-0.6	-0.7	0.0
Tense / ‘highly strung’	0.2	0.3	1.0	-0.7	0.5	0.3	0.4	0.3	0.2	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.2	0.8	0.9	0.7	0.5	-0.2	-0.0	-0.1	0.3
Pulse wave reflection index	0.2	0.2	0.8	0.2	-0.0	0.0	0.9	0.0	-0.1	-0.7
Headache pain in last month	0.2	0.4	1.6	1.3	0.1	-0.1	0.1	-0.1	-0.2	-0.9
Glaucoma (self-reported)	0.2	0.2	1.0	1.0	-0.5	-0.1	0.5	0.2	0.3	0.1
Health satisfaction	0.2	0.2	1.0	-0.2	0.4	0.4	1.0	0.4	0.4	0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.6	-0.4	0.7	0.5	0.8	0.3	0.3	0.6
Angina (self-reported)	0.2	0.2	0.9	-0.1	-0.4	-0.2	-0.9	-0.4	-0.4	-0.1
Medication: Seretide 50 evohaler	0.2	0.2	0.7	0.9	0.6	0.6	-0.1	0.1	0.0	-0.4
Illnesses of siblings: Diabetes	0.2	0.2	1.2	-1.1	-0.3	-0.3	-0.4	-0.2	-0.1	0.0
Arm fat percentage (left)	0.2	0.7	1.2	-0.3	-1.1	-1.1	-0.7	-0.8	-0.4	-1.0
Eye problems/disorders: Cataract	0.2	0.3	0.8	0.6	-0.5	-0.3	-0.9	-0.5	-0.3	-0.1
Osteoarthritis (self-reported)	0.2	0.2	0.5	0.6	-0.7	-0.4	-0.5	-0.4	-0.3	-0.1
Illnesses of father: None of the above (group 1)	0.2	0.3	0.9	1.0	-0.7	-0.2	-0.4	-0.1	-0.2	-0.4
Smoking status: Current	0.2	0.3	1.0	-1.0	0.1	-0.2	-0.9	-0.3	-0.4	0.2
Hearing aid user	0.2	0.2	0.5	-0.4	-0.4	-0.5	-0.2	-0.6	-0.4	-0.7
Financial situation satisfaction	0.2	0.3	0.8	0.9	0.1	0.4	0.8	0.3	0.4	-0.2
Leg fat percentage (left)	0.2	0.6	2.0	-0.2	-0.9	-0.9	-0.3	-0.4	0.0	-1.4
Average weekly beer plus cider intake	0.2	0.3	1.0	-0.8	-0.3	-0.3	-1.0	-0.4	-0.2	-0.1
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.8	0.2	-0.4	-0.2	-0.9	-0.2	-0.4	0.3
Commuting to job workplace: Cycle	0.2	0.3	0.5	-0.7	0.5	0.4	0.2	0.6	0.6	0.5
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	0.5	0.0	0.2	0.6	0.5	0.7	0.5
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.6	0.5	0.3	0.4	-0.0	0.0	-0.8
Worry (Nagel 2018)	0.1	0.1	0.5	-0.4	0.3	0.1	0.2	-0.1	0.1	-0.7
Alzheimer’s Disease (including proxy)	0.1	0.1	0.2	-0.3	0.1	0.2	0.4	0.4	0.4	-0.1
Breast Cancer	0.1	0.2	0.5	0.2	0.4	0.4	0.7	0.3	0.5	-0.4
Ovarian Cancer	0.1	0.1	0.2	0.2	0.3	0.4	0.4	0.2	0.3	-0.1
Neuroticism (2016)	0.1	0.1	0.2	-0.4	-0.3	-0.1	-0.4	-0.1	-0.3	-0.3
Heel T-Score	0.1	0.6	1.5	0.7	0.6	0.7	1.2	0.9	0.7	0.4
Smoking Status	0.1	0.2	0.4	-0.5	0.4	0.3	0.0	0.6	0.6	0.5
Number of treatments/medications taken	0.1	0.2	0.6	0.4	0.1	-0.0	-0.5	-0.2	-0.4	-0.7
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	-0.2	-0.3	-0.2	-0.3	-0.3	-0.3	-0.1
Qualifications: CSEs or equivalent	0.1	0.1	0.3	0.6	-0.0	0.2	0.3	0.3	0.2	0.4
Multivitamins +/- minerals	0.1	0.1	0.2	-0.2	0.2	0.0	0.5	0.4	0.3	0.3
Medication: Levothyroxine sodium	0.1	0.2	1.2	-1.1	0.1	0.0	0.3	-0.2	-0.2	0.4
Financial difficulties in last 2 years	0.1	0.1	0.3	0.2	-0.3	-0.3	0.6	0.0	0.0	-0.3
Mouth/teeth dental problems	0.1	0.1	0.7	-0.9	0.0	0.0	0.2	-0.2	-0.3	-0.2
Fluid intelligence score	0.1	0.2	1.0	-1.0	-0.2	-0.3	-0.3	-0.3	-0.4	-0.1
Illnesses of siblings	0.1	0.2	0.6	0.8	-0.3	-0.1	0.2	-0.3	-0.5	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.8	-0.0	-0.6	-0.4	-0.9	-0.5	-0.6	-0.4
Pulse wave Arterial Stiffness index	0.1	0.1	0.6	0.2	0.3	0.2	0.7	0.1	0.1	-0.1
Impedance of arm (left)	0.1	0.2	0.6	0.2	0.7	0.7	-0.3	0.5	0.3	0.4
Breastfed as a baby	0.1	0.1	0.2	0.4	0.2	0.3	0.5	0.4	0.3	0.5
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.4	0.5	0.4	0.0	0.0	-0.1	-0.2
High blood pressure (siblings)	0.1	0.2	0.3	-0.6	0.5	0.5	-0.2	0.5	0.5	0.3
Leg fat percentage (right)	0.1	0.4	1.8	-0.2	-0.5	-0.7	-0.3	-0.3	0.2	-1.3
Comparative body size at age 10	0.1	0.3	0.6	-0.3	-0.5	-0.6	-0.7	-0.7	-0.8	-0.4
Number of full brothers	0.1	0.1	0.3	-0.2	0.2	0.2	-0.4	0.3	0.2	0.5
Worry too long after embarrassment	0.1	0.1	0.6	-0.7	0.2	0.2	-0.2	0.1	0.1	0.2
Medication for pain relief, constipation, heartburn	0.1	0.1	0.5	-0.5	-0.3	-0.2	-0.1	-0.3	-0.1	0.7
Medication: Blood pressure	0.1	0.2	0.9	0.5	0.4	0.3	-0.4	0.1	0.1	0.9
Pulse rate, automated reading	0.1	0.3	0.7	0.8	0.1	-0.0	-0.7	-0.3	-0.4	0.7
Comparative height size at age 10	0.1	0.7	1.2	-0.4	-1.1	-0.9	-0.6	-0.8	-0.8	-1.1
Ever had bowel cancer screening	0.1	0.1	0.2	0.3	-0.2	-0.1	-0.4	-0.4	-0.4	0.4
Medication: Aspirin	0.1	0.2	0.5	0.2	0.7	0.5	0.3	0.4	0.3	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.1	0.3	-0.0	-0.6	-0.5	-0.4	-0.4	-0.4	-0.2
Number of self-reported non-cancer illnesses	0.1	0.2	0.5	0.7	-0.2	-0.2	-0.3	-0.6	-0.7	-0.1
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	-0.0	-0.5	-0.6	-0.6	-0.4	-0.4	0.0
Medication: Atorvastatin	0.1	0.1	0.4	-0.6	0.2	0.2	0.5	0.3	0.1	-0.2
Ever smoked	0.1	0.2	1.3	1.1	-0.5	-0.3	-0.1	-0.1	-0.0	0.4
Number of operations (self-reported)	0.1	0.2	0.8	0.3	-0.4	-0.2	-0.9	-0.3	-0.4	0.0
Schizophrenia vs Biploar Disorder	0.0	0.0	0.1	0.3	0.1	0.1	-0.0	-0.2	-0.2	-0.1
Blood Eosinophil Count	0.0	0.1	0.7	-0.2	-0.2	-0.4	-0.3	-0.0	0.0	-0.8
Blood White Count	0.0	0.2	0.9	-0.0	0.0	-0.3	-0.4	-0.5	-0.5	-0.9
Systolic Blood Pressure	0.0	0.1	0.3	-0.5	-0.1	-0.4	-0.5	-0.3	-0.2	0.1
Taking other prescription medications	0.0	0.0	0.2	-0.4	-0.1	-0.1	0.2	0.2	0.2	-0.0
Supplements: Glucosamine	0.0	0.1	0.2	0.1	-0.3	-0.0	-0.4	0.3	0.2	-0.2
Medication: Simvastatin	0.0	0.1	0.1	0.2	0.3	0.3	0.2	0.1	-0.0	-0.3
Impedance of arm (right)	0.0	0.2	0.3	-0.3	0.6	0.5	-0.6	0.4	0.3	0.3
Qualifications: College or University degree	0.0	0.1	0.2	-0.4	-0.4	-0.3	0.1	0.2	0.4	-0.3
Eye problems/disorders: None of the above	0.0	0.1	0.2	0.0	-0.2	-0.0	-0.0	-0.3	-0.5	0.3
Had major operations	0.0	0.0	0.1	-0.2	-0.3	-0.3	0.3	0.0	0.1	0.2
Medication: Aspirin	0.0	0.0	0.2	0.1	0.4	0.2	-0.1	0.1	-0.1	0.1
Mineral and other dietary supplements	0.0	0.1	0.3	0.3	0.1	0.1	0.5	-0.1	0.0	-0.0
Diastolic blood pressure, automated reading	0.0	0.1	0.3	0.1	0.6	0.0	-0.2	-0.1	-0.0	0.1

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