[Hub]/) : Traits : Waist Hip Ratio (WHR) : ← →

chr22:28,387,749-32,756,899

Best TWAS P=1.28e-17 · Best GWAS P=2.36e-32 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	CCDC157	0.04	0.05	lasso	3	0.04	6.3e-06	6.7	6.2	7.1e-10	0.03	0.38	0.60	FALSE
2	CommonMind	Brain Pre-frontal Cortex	LIMK2	0.06	0.08	enet	7	0.07	1.2e-08	-5.6	5.6	1.9e-08	0.02	0.08	0.92	FALSE
3	CommonMind	Brain Pre-frontal Cortex	RNF215	0.03	0.00	blup	442	0.00	1.9e-01	-2.4	-6.8	1.4e-11	-0.07	0.12	0.05	FALSE
4	GTEx	Adipose Subcutaneous	KREMEN1	0.19	0.13	enet	22	0.13	9.2e-11	-3.9	-5.6	2.6e-08	0.16	1.00	0.00	FALSE
5	GTEx	Adipose Visceral Omentum	RP1-130H16.16	0.23	0.22	lasso	7	0.19	3.1e-10	6.7	-6.1	9.1e-10	-0.01	0.48	0.52	FALSE
6	GTEx	Adrenal Gland	RP1-130H16.16	0.21	0.03	enet	11	0.10	2.1e-04	6.7	-6.8	1.2e-11	-0.04	0.16	0.21	FALSE
7	GTEx	Artery Aorta	RP1-130H16.16	0.23	0.24	lasso	7	0.23	4.6e-13	6.3	-6.4	1.7e-10	-0.01	0.93	0.07	TRUE
8	GTEx	Artery Coronary	RP1-130H16.16	0.28	0.00	lasso	13	0.04	1.5e-02	6.7	-6.3	3.8e-10	-0.01	0.08	0.34	FALSE
9	GTEx	Artery Tibial	THOC5	0.61	0.61	enet	53	0.69	1.0e-74	5.0	-6.3	3.5e-10	0.10	1.00	0.00	TRUE
10	GTEx	Artery Tibial	RP1-130H16.16	0.12	0.11	enet	19	0.12	2.0e-09	6.7	-5.3	1.4e-07	-0.05	0.89	0.11	FALSE
11	GTEx	Brain Frontal Cortex BA9	RP1-130H16.16	0.20	0.12	lasso	10	0.15	8.4e-05	6.3	-5.8	7.1e-09	-0.03	0.03	0.92	FALSE
12	GTEx	Breast Mammary Tissue	RP1-130H16.16	0.14	0.05	lasso	6	0.07	1.5e-04	6.8	-6.1	1.3e-09	0.00	0.27	0.71	FALSE
13	GTEx	Cells Transformed fibroblasts	RP1-130H16.16	0.25	0.22	enet	31	0.21	1.0e-15	6.7	-6.1	8.8e-10	0.00	0.91	0.09	FALSE
14	GTEx	Colon Sigmoid	RP1-130H16.16	0.27	0.25	lasso	17	0.24	5.1e-09	6.7	-6.2	5.2e-10	-0.02	0.86	0.13	FALSE
15	GTEx	Colon Transverse	RP1-130H16.16	0.28	0.20	lasso	6	0.20	1.1e-09	6.7	-6.2	6.9e-10	-0.02	0.92	0.08	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	THOC5	0.60	0.58	enet	28	0.57	1.6e-24	5.0	-5.2	1.9e-07	0.03	1.00	0.00	FALSE
17	GTEx	Esophagus Mucosa	SFI1	0.13	0.11	lasso	6	0.10	3.9e-07	-5.6	6.0	2.4e-09	0.03	0.04	0.96	FALSE
18	GTEx	Esophagus Mucosa	RP1-130H16.16	0.11	0.13	enet	26	0.13	9.3e-09	6.7	-6.5	7.7e-11	-0.02	0.28	0.71	FALSE
19	GTEx	Esophagus Mucosa	MTFP1	0.10	0.00	lasso	6	0.01	1.3e-01	6.3	5.9	3.1e-09	0.03	0.17	0.17	TRUE
20	GTEx	Esophagus Muscularis	SFI1	0.22	0.13	enet	20	0.15	3.7e-09	-6.0	5.7	9.2e-09	0.00	0.01	0.99	FALSE
21	GTEx	Esophagus Muscularis	RP1-130H16.16	0.20	0.14	lasso	4	0.14	1.5e-08	6.3	-5.8	5.9e-09	0.00	0.91	0.09	FALSE
22	GTEx	Heart Atrial Appendage	RNF215	0.46	0.46	lasso	6	0.43	4.2e-21	6.3	6.3	2.9e-10	0.02	0.93	0.07	FALSE
23	GTEx	Heart Atrial Appendage	CCDC157	0.38	0.29	lasso	7	0.31	1.2e-14	6.7	6.6	3.3e-11	0.02	0.92	0.08	FALSE
24	GTEx	Heart Left Ventricle	RNF215	0.21	0.26	enet	11	0.24	4.3e-13	6.3	6.4	1.6e-10	0.02	0.93	0.07	FALSE
25	GTEx	Heart Left Ventricle	CCDC157	0.10	0.02	lasso	3	0.03	7.9e-03	5.8	6.2	5.5e-10	-0.01	0.06	0.89	FALSE
26	GTEx	Lung	RP1-130H16.16	0.08	0.08	enet	13	0.08	1.9e-06	6.3	-6.6	3.2e-11	-0.01	0.64	0.30	FALSE
27	GTEx	Muscle Skeletal	SFI1	0.13	0.09	enet	22	0.10	1.7e-10	4.2	6.0	1.9e-09	-0.01	0.35	0.65	FALSE
28	GTEx	Muscle Skeletal	RP1-130H16.16	0.07	0.04	lasso	3	0.03	4.7e-04	5.8	-6.5	8.1e-11	-0.05	0.23	0.53	FALSE
29	GTEx	Nerve Tibial	RNF215	0.08	0.07	lasso	2	0.06	9.3e-05	6.8	-6.8	1.4e-11	-0.02	0.33	0.62	FALSE
30	GTEx	Nerve Tibial	GATSL3	0.10	0.04	lasso	9	0.03	1.8e-03	6.7	-6.6	5.4e-11	-0.01	0.29	0.68	FALSE
31	GTEx	Nerve Tibial	RP1-130H16.16	0.19	0.16	enet	24	0.17	2.4e-12	6.7	-5.2	2.2e-07	0.00	0.92	0.08	FALSE
32	GTEx	Ovary	THOC5	0.59	0.40	lasso	11	0.48	1.6e-13	5.0	-5.1	2.8e-07	0.01	0.97	0.00	FALSE
33	GTEx	Pancreas	CCDC157	0.14	0.06	lasso	3	0.07	8.7e-04	6.7	-5.5	3.4e-08	-0.03	0.28	0.13	TRUE
34	GTEx	Pancreas	RP1-130H16.16	0.16	0.13	lasso	7	0.11	2.3e-05	6.7	-6.8	1.3e-11	-0.02	0.58	0.27	FALSE
35	GTEx	Prostate	RP1-130H16.16	0.24	0.01	lasso	7	0.02	8.2e-02	7.7	-7.4	1.6e-13	0.05	0.02	0.80	TRUE
36	GTEx	Skin Not Sun Exposed Suprapubic	SFI1	0.12	0.00	enet	12	0.05	1.4e-03	-6.1	5.4	5.4e-08	0.00	0.05	0.86	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	RP1-130H16.16	0.16	0.13	enet	24	0.14	3.0e-08	6.3	-5.6	2.5e-08	0.01	0.91	0.09	FALSE
38	GTEx	Skin Sun Exposed Lower leg	CCDC117	0.07	0.03	enet	11	0.03	2.8e-03	-3.8	5.8	5.1e-09	-0.37	0.13	0.44	FALSE
39	GTEx	Skin Sun Exposed Lower leg	CCDC157	0.15	0.06	lasso	3	0.04	5.0e-04	6.3	-6.3	3.7e-10	-0.02	0.53	0.19	FALSE
40	GTEx	Skin Sun Exposed Lower leg	RP1-130H16.16	0.13	0.10	lasso	2	0.08	1.8e-07	6.3	-6.4	2.1e-10	-0.01	0.82	0.18	FALSE
41	GTEx	Small Intestine Terminal Ileum	THOC5	0.34	0.09	enet	35	0.17	1.2e-04	5.0	-5.9	3.5e-09	0.05	0.20	0.07	FALSE
42	GTEx	Spleen	CCDC157	0.25	0.01	lasso	14	0.02	8.6e-02	6.8	-5.6	1.9e-08	0.01	0.08	0.40	FALSE
43	GTEx	Spleen	RP1-130H16.16	0.35	0.27	lasso	3	0.25	4.9e-07	6.7	-6.8	1.3e-11	-0.01	0.41	0.47	FALSE
44	GTEx	Stomach	CCDC157	0.21	0.02	lasso	5	0.03	9.2e-03	6.3	-5.7	1.1e-08	-0.07	0.12	0.62	TRUE
45	GTEx	Stomach	RP1-130H16.16	0.16	0.12	lasso	7	0.07	2.9e-04	6.8	-7.0	3.4e-12	-0.02	0.08	0.91	FALSE
46	GTEx	Testis	CCDC157	0.47	0.22	lasso	11	0.29	1.8e-13	7.7	6.6	3.6e-11	0.03	0.01	0.99	FALSE
47	GTEx	Testis	GATSL3	0.13	0.09	lasso	3	0.16	1.8e-07	6.5	-6.0	2.2e-09	0.01	0.03	0.86	TRUE
48	GTEx	Testis	RP1-130H16.16	0.25	0.17	lasso	4	0.20	3.3e-09	7.7	7.5	7.1e-14	0.02	0.00	1.00	TRUE
49	GTEx	Thyroid	LIMK2	0.06	0.05	lasso	2	0.04	4.7e-04	-5.1	5.2	2.2e-07	0.04	0.18	0.70	FALSE
50	GTEx	Thyroid	SFI1	0.12	0.10	lasso	12	0.11	1.4e-08	-6.1	5.6	1.8e-08	0.02	0.02	0.98	FALSE
51	GTEx	Thyroid	RP1-130H16.16	0.19	0.18	lasso	7	0.19	8.8e-15	6.3	-6.8	1.5e-11	-0.01	0.89	0.11	FALSE
52	GTEx	Whole Blood	PISD	0.06	0.04	enet	16	0.05	2.9e-05	-4.3	5.3	9.7e-08	-0.02	0.30	0.51	FALSE
53	METSIM	Adipose	CHEK2	0.05	0.04	bslmm	319	0.04	1.0e-06	4.9	-7.5	8.0e-14	0.27	0.97	0.01	TRUE
54	METSIM	Adipose	RNF185	0.10	0.07	lasso	12	0.07	3.3e-10	-5.6	-6.0	1.9e-09	-0.01	0.10	0.90	FALSE
55	YFS	Blood	CHEK2	0.02	0.02	lasso	1	0.02	1.3e-06	5.1	5.1	2.8e-07	-0.18	1.00	0.00	FALSE
56	YFS	Blood	LIMK2	0.04	0.04	enet	9	0.06	3.6e-18	-4.2	-5.4	6.1e-08	-0.02	0.12	0.88	FALSE
57	YFS	Blood	PIK3IP1	0.14	0.21	enet	25	0.21	5.6e-67	-5.6	5.4	7.3e-08	0.02	0.09	0.91	FALSE
58	YFS	Blood	RNF185	0.04	0.03	lasso	4	0.03	2.8e-09	-6.0	-6.3	3.6e-10	0.00	0.01	0.99	TRUE
59	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	SELM	0.06	0.01	blup	54	0.02	5.2e-03	4.1	-5.2	1.6e-07	-0.02	0.04	0.60	FALSE
60	The Cancer Genome Atlas	Breast Invasive Carcinoma	C22orf31	0.04	0.02	blup	67	0.01	2.6e-03	-9.4	8.5	1.3e-17	-0.70	0.00	0.97	TRUE
61	The Cancer Genome Atlas	Breast Invasive Carcinoma	CCDC157	0.03	0.01	blup	64	0.02	9.1e-06	-2.6	5.6	2.2e-08	0.04	0.68	0.28	FALSE
62	The Cancer Genome Atlas	Breast Invasive Carcinoma	RFPL1	0.07	0.00	blup	43	0.01	6.7e-03	-4.3	-5.4	5.7e-08	0.05	0.00	0.04	FALSE
63	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC157	0.11	0.09	lasso	13	0.10	1.5e-11	5.8	6.6	3.5e-11	0.00	0.72	0.28	TRUE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	LIMK2	0.06	0.06	blup	47	0.06	9.3e-08	-5.6	5.5	4.1e-08	0.02	0.03	0.97	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	ZNRF3	0.08	0.02	enet	18	0.02	1.5e-03	-6.6	-5.7	1.3e-08	0.02	0.25	0.02	FALSE
66	The Cancer Genome Atlas	Lung Adenocarcinoma	CCDC157	0.03	0.02	blup	64	0.03	1.6e-04	3.3	5.5	3.7e-08	0.05	0.32	0.16	FALSE
67	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CCDC157	0.09	0.01	blup	64	0.06	2.1e-03	6.3	6.4	1.7e-10	-0.02	0.03	0.15	TRUE
68	The Cancer Genome Atlas	Prostate Adenocarcinoma	GATSL3	0.10	0.07	blup	57	0.09	6.1e-10	6.7	-5.7	1.0e-08	0.05	0.25	0.75	FALSE
69	The Cancer Genome Atlas	Prostate Adenocarcinoma	SEC14L2	0.12	0.08	blup	74	0.12	1.1e-12	5.8	-6.4	1.3e-10	0.01	0.63	0.37	FALSE
70	The Cancer Genome Atlas	Soft Tissue Sarcoma	THOC5	0.05	0.05	blup	58	0.03	8.0e-03	5.0	-5.3	1.1e-07	0.00	0.01	0.86	TRUE
71	The Cancer Genome Atlas	Skin Cutaneous Melanoma	ZNRF3	0.44	-0.01	blup	126	0.05	2.0e-02	2.1	-6.5	7.0e-11	0.10	0.02	0.09	TRUE
72	The Cancer Genome Atlas	Thyroid Carcinoma	CCDC157	0.04	0.03	blup	64	0.04	5.8e-05	6.3	6.0	2.2e-09	0.03	0.41	0.49	FALSE