Best TWAS P=1.32e-15 · Best GWAS P=3.74e-15 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | SLC35F5 | 0.22 | 0.07 | enet | 24 | 0.10 | 1.6e-04 | -4.0 | -6.5 | 8.8e-11 | 0.68 | 0.04 | 0.86 | FALSE |
| 2 | GTEx | Artery Aorta | SLC35F5 | 0.09 | 0.04 | enet | 8 | 0.07 | 1.5e-04 | 3.4 | -6.5 | 1.0e-10 | 0.61 | 0.07 | 0.68 | FALSE |
| 3 | GTEx | Brain Cerebellum | RABL2A | 0.20 | 0.03 | lasso | 7 | 0.03 | 4.4e-02 | -5.7 | 5.8 | 6.8e-09 | -0.68 | 0.06 | 0.13 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Female) | RPL23AP7 | 0.17 | 0.09 | lasso | 3 | 0.15 | 3.7e-05 | -3.7 | 5.7 | 1.4e-08 | -0.60 | 0.16 | 0.47 | FALSE |
| 5 | GTEx | Skin Sun Exposed Lower leg | ACTR3 | 0.17 | 0.19 | lasso | 2 | 0.17 | 3.6e-14 | -5.2 | 5.2 | 2.1e-07 | -0.32 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Thyroid | SLC35F5 | 0.37 | 0.21 | enet | 20 | 0.24 | 1.3e-18 | -5.9 | 5.2 | 2.1e-07 | -0.76 | 0.96 | 0.04 | FALSE |
| 7 | METSIM | Adipose | CBWD2 | 0.20 | 0.01 | enet | 28 | 0.09 | 5.4e-14 | -7.3 | 5.2 | 1.6e-07 | -0.54 | 0.06 | 0.94 | FALSE |
| 8 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ACTR3 | 0.05 | 0.02 | lasso | 4 | 0.02 | 1.3e-02 | -7.8 | 8.0 | 1.3e-15 | -0.97 | 0.00 | 0.89 | TRUE |
| 9 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | DDX11L2 | 0.08 | 0.04 | enet | 4 | 0.06 | 5.0e-06 | -5.3 | 5.5 | 3.0e-08 | -0.42 | 0.00 | 0.90 | FALSE |
| 10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ACTR3 | 0.02 | 0.03 | lasso | 2 | 0.02 | 8.7e-06 | -7.3 | 7.3 | 2.3e-13 | -0.92 | 0.02 | 0.98 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | DDX11L2 | 0.10 | 0.04 | enet | 5 | 0.10 | 8.1e-20 | -2.4 | 5.5 | 4.2e-08 | -0.44 | 0.43 | 0.17 | FALSE |
| 12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | DDX11L2 | 0.14 | 0.05 | lasso | 2 | 0.13 | 1.1e-14 | -5.3 | 5.7 | 1.2e-08 | -0.42 | 0.00 | 1.00 | FALSE |
| 13 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | DDX11L2 | 0.19 | 0.03 | enet | 3 | 0.11 | 5.5e-07 | -5.3 | 5.5 | 2.8e-08 | -0.39 | 0.00 | 0.99 | FALSE |
| 14 | The Cancer Genome Atlas | Brain Lower Grade Glioma | DDX11L2 | 0.20 | 0.08 | lasso | 4 | 0.13 | 1.3e-14 | -5.3 | 5.6 | 2.7e-08 | -0.41 | 0.00 | 1.00 | FALSE |
| 15 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | DDX11L2 | 0.16 | 0.02 | enet | 5 | 0.12 | 2.0e-06 | -2.4 | 5.2 | 2.1e-07 | -0.41 | 0.00 | 0.62 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | DDX11L2 | 0.14 | 0.08 | lasso | 3 | 0.11 | 6.2e-13 | -5.3 | 5.5 | 2.8e-08 | -0.42 | 0.00 | 1.00 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | DDX11L2 | 0.12 | 0.11 | enet | 5 | 0.13 | 3.1e-14 | -5.3 | 5.6 | 2.6e-08 | -0.42 | 0.00 | 1.00 | FALSE |
| 18 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ACTR3 | 0.08 | 0.12 | enet | 8 | 0.07 | 7.7e-04 | -5.0 | 5.3 | 8.7e-08 | -0.48 | 0.20 | 0.23 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ACTR3 | 0.06 | 0.00 | enet | 17 | 0.03 | 3.8e-04 | -6.7 | 6.6 | 4.4e-11 | -0.50 | 0.01 | 0.51 | FALSE |
| 20 | The Cancer Genome Atlas | Stomach Adenocarcinoma | DDX11L2 | 0.15 | 0.03 | blup | 5 | 0.11 | 3.4e-08 | -2.4 | 5.1 | 2.8e-07 | -0.36 | 0.01 | 0.87 | FALSE |
| 21 | The Cancer Genome Atlas | Thyroid Carcinoma | ACTR3 | 0.10 | 0.05 | lasso | 4 | 0.04 | 1.2e-04 | -7.3 | 8.0 | 1.9e-15 | -0.89 | 0.02 | 0.95 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | DDX11L2 | 0.15 | 0.02 | enet | 4 | 0.12 | 1.0e-11 | -5.3 | 5.3 | 1.0e-07 | -0.39 | 0.00 | 1.00 | FALSE |