Hub : Genes

CBWD2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.570	0.1240	6.4e-04	0.049	NA	0.014	NA	0.030	1.1e-02	NA	1.1e-01	NA	3.6e-02
2	GTEx	Cells Transformed fibroblasts	0.164	0.0470	1.9e-05	0.141	NA	0.128	NA	0.142	1.1e-10	NA	8.4e-10	NA	9.2e-11
3	GTEx	Thyroid	0.328	0.0640	5.7e-07	0.147	NA	0.124	NA	0.151	2.5e-11	NA	1.1e-09	NA	1.2e-11
4	METSIM	Adipose	0.196	0.0492	1.4e-08	0.014	0.084	0.095	0.094	0.083	2.7e-03	1.6e-12	5.4e-14	6.9e-14	2.2e-12
5	ROSMAP	Brain Pre-frontal Cortex	0.186	0.0473	9.2e-09	0.100	0.075	0.105	0.103	0.102	7.9e-13	6.3e-10	2.4e-13	3.7e-13	4.8e-13

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.1	0.1	0.2	-0.4	-0.0	-0.4	-0.2	-0.1
Bipolar Disorder or Schizophrenia	0.8	1.9	3.4	-1.6	-1.4	-1.1	0.6	1.8
Depressed Affect (Nagel 2018)	1.2	2.5	4.7	-1.9	-2.2	-1.9	-0.6	0.6
Depression (Nagel 2018)	1.3	2.0	5.0	-2.2	-1.9	-0.5	-1.1	0.0
Intelligence (Savage-Jansen 2018)	0.7	2.3	4.3	-1.2	-1.4	-1.6	2.1	1.1
Neuroticism (Nagel 2018)	0.1	0.2	0.6	-0.1	-0.4	-0.3	-0.7	0.2
Schizophrenia (2018)	1.4	3.0	6.6	-1.8	-1.8	-1.1	1.0	2.6
Schizophrenia vs Biploar Disorder	0.5	0.7	1.3	-0.6	-1.1	-1.0	0.4	0.9
Worry (Nagel 2018)	1.0	2.1	4.1	1.7	1.7	2.0	-0.5	-0.4
Alzheimer’s Disease (in mother)	2.1	2.5	5.4	-2.3	-1.9	-0.9	1.0	1.2
Alzheimer’s Disease (in father)	1.2	1.3	3.4	1.8	1.5	0.5	0.6	-0.8
Alzheimer’s Disease (including proxy)	0.3	0.4	1.2	-0.7	-0.6	-0.4	1.1	0.2
Crohns Disease (2017)	1.1	2.4	4.5	-2.1	-1.0	-2.0	0.9	1.3
Irritable Bowel Disease (IBD)	0.9	2.2	7.3	-2.7	-1.2	-1.0	0.6	0.9
Ulcerative Colitis (UC)	0.6	1.0	3.6	-1.9	-0.4	1.1	-0.5	-0.2
Major Depression (MDD)	0.8	0.9	2.0	-1.0	-1.0	-1.4	0.1	0.9
Reaction Time	0.4	0.7	2.0	1.1	1.4	0.2	-0.2	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.8	-0.7	-0.8	-0.9	0.9	0.2
Breast Cancer	0.1	0.3	0.7	-0.6	-0.2	0.8	0.5	-0.4
Ovarian Cancer	1.5	2.0	5.1	2.3	1.7	0.4	-1.2	-0.6
Prostate Cancer	0.6	0.8	2.9	-1.7	-0.9	0.2	-0.5	0.3
Age at First Birth	1.1	1.6	3.7	1.9	1.5	-1.2	0.7	-0.4
Bipolar Disorder (2011)	2.0	2.0	3.2	-1.8	-1.2	-0.5	1.7	1.5
Body Mass Index (BMI) (2010)	0.4	0.6	1.3	-0.7	-0.1	1.2	-0.2	1.0
Coronary Artery Disease (CAD)	1.9	2.3	4.9	-1.6	-0.8	1.4	1.2	2.2
Crohns Disease (2012)	1.3	2.1	3.7	-1.8	-1.3	-1.9	1.0	0.9
Mean Putamen Volume	0.2	0.2	0.8	-0.4	-0.1	0.4	0.3	0.9
Fasting Glucose	0.6	0.7	1.6	1.0	0.7	1.2	0.0	-0.8
HbA1C	1.9	2.2	5.8	1.4	1.4	2.4	-0.5	-0.9
HDL Cholesterol	0.4	0.7	2.2	0.0	-0.4	-0.8	1.5	0.8
LDL Cholesterol	0.5	0.8	2.7	0.7	-0.0	-1.6	0.5	0.7
Lupus	0.2	0.3	0.9	-0.4	0.2	0.1	-0.9	-0.5
Neuroticism (2016)	2.7	3.9	7.0	-2.6	-2.6	0.2	1.3	2.0
Primary Biliary Cirrhosis	1.4	2.1	5.6	-1.9	-0.5	0.6	2.4	0.6
Rheumatoid Arthritis	0.8	1.2	2.6	-1.6	-1.2	1.0	0.8	0.1
Schizophrenia (2014)	1.0	2.1	3.6	-1.4	-1.6	-1.4	1.0	1.9
Triglycerides	0.1	0.2	0.4	0.4	0.5	0.5	-0.1	0.6
Type 2 Diabetes (T2D) (2012)	0.8	0.9	2.3	-1.5	-0.6	1.1	-0.3	0.9
Ulcerative Colitis	0.4	0.6	1.9	-1.4	-0.1	0.6	0.6	-0.5
Blood Eosinophil Count	0.3	2.1	3.7	-1.9	-1.5	-1.4	0.6	1.5
Blood Platelet Count	0.1	1.5	3.0	-1.7	-1.7	-0.5	0.9	-0.5
Blood Red Count	0.6	5.7	13.8	-3.7	-2.6	1.3	2.5	0.5
Blood White Count	1.2	8.6	20.8	-4.6	-2.9	-2.3	-2.6	-1.3
Heel T-Score	0.4	3.1	11.2	0.8	0.9	3.4	0.7	-1.6
BMI	1.0	6.0	15.1	-3.9	-2.5	0.9	1.8	2.0
Height	0.2	4.5	15.1	0.8	-0.6	0.1	3.9	2.6
Waist Hip Ratio (WHR)	2.2	9.8	27.5	-1.6	-2.4	-0.6	5.2	3.6
Systolic Blood Pressure	1.3	6.7	21.4	1.4	2.5	4.6	1.9	-0.4
Smoking Status	0.5	1.1	3.2	-0.2	-0.2	1.4	1.8	0.7
Allergy or Eczema	0.4	1.0	1.7	-1.1	0.6	-1.0	1.0	1.3
Cardiovascular Disease	1.9	6.3	11.7	-1.1	-0.2	3.3	3.4	2.8
Hypothyroidism (self reported)	0.0	0.0	0.0	-0.2	0.1	-0.2	0.0	0.2
Respiratory disease	1.3	3.0	6.5	-2.5	-2.2	-0.2	-0.6	1.8
Type 2 Diabetes (T2D) (2018)	1.1	2.1	2.7	-0.8	-1.5	-1.6	1.6	1.4
Lung FEV1/FVC ratio	0.1	0.3	0.7	-0.3	0.0	0.9	0.7	-0.1
Lung FVC	0.5	2.6	6.5	2.5	1.5	0.9	-1.8	-0.6
Neuroticism	0.2	0.4	1.7	0.1	-0.1	0.3	-1.3	0.4
Chronotype (morning person)	0.3	0.7	1.2	-1.1	0.5	0.9	1.1	0.2
Hair Pigment	0.0	0.6	1.7	-0.4	-0.0	0.6	-1.3	-0.8
Tanning	0.2	2.1	4.0	-2.0	-0.7	1.9	0.1	1.5
Hand grip strength (left)	0.8	2.2	3.6	1.6	1.5	1.0	-1.4	-1.9
Number of treatments/medications taken	1.2	2.2	3.1	-1.5	-1.3	1.0	1.8	1.6
Average weekly spirits intake	2.6	3.2	8.6	-2.9	-2.1	-1.3	-0.7	0.8
Sensitivity / hurt feelings	0.7	1.2	2.5	-1.0	-1.3	-0.9	0.4	1.6
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.6	-1.1	-1.3	0.7	-0.2	0.1
Hearing difficulty/problems: Yes	0.3	0.5	1.8	-0.2	-0.8	-0.3	-1.3	-0.4
Relative age of first facial hair	0.3	0.7	2.3	0.4	-0.0	-1.5	-0.3	-1.0
Other serious medical condition/disability diagnosed by doctor	3.8	4.9	8.9	-3.0	-2.5	-0.6	1.1	2.8
Ever used hormone-replacement therapy (HRT)	1.6	2.0	8.6	0.6	0.4	-0.2	-2.9	-0.8
Ever had hysterectomy (womb removed)	0.8	0.9	1.6	-0.8	-0.7	-1.2	-1.0	0.8
Systolic blood pressure, automated reading	0.9	2.5	5.3	1.8	2.0	2.3	0.1	-0.3
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.2	-0.4	-0.5	-0.6	0.5	1.1
Angina	0.1	0.1	0.2	0.4	0.2	0.4	-0.3	-0.1
Medication for hormone replacement therapy	0.8	0.8	2.9	-0.2	0.2	0.1	-1.7	-1.1
Vitamin and mineral supplements	0.5	0.7	1.6	0.2	0.5	1.3	0.3	1.2
Supplements: Zinc	0.7	0.8	1.8	0.6	0.8	1.0	-1.4	-0.2
Medication: Co-codamol	0.1	0.1	0.1	-0.3	-0.3	0.2	0.2	-0.2
Medication: Metformin	0.9	1.2	2.1	-1.0	-0.8	-0.8	1.5	1.3
Diabetes (father)	0.2	0.2	0.5	-0.7	-0.2	-0.6	-0.4	0.1
Diabetes (mother)	1.1	1.4	3.2	-0.7	-1.2	-1.8	0.6	1.3
Severe depression (siblings)	0.2	0.3	0.6	0.5	-0.4	-0.5	-0.7	-0.3
Pack years adult smoking proportion	3.1	4.7	9.1	-3.0	-2.9	-1.2	1.1	1.8
Impedance of leg (right)	0.3	1.2	2.9	0.8	0.6	-1.7	-1.2	-0.9
Leg fat-free mass (left)	0.6	3.1	6.1	-1.7	-1.2	1.0	2.5	1.9
Trunk fat percentage	0.7	2.8	7.5	-2.7	-1.4	0.4	1.9	0.9
Hand grip strength (right)	0.3	0.9	2.5	0.5	1.1	0.6	-0.3	-1.6
Townsend deprivation index at recruitment	1.6	2.3	4.2	-2.0	-2.0	0.2	1.6	0.9
Current tobacco smoking	0.2	0.4	0.8	-0.4	-0.6	-0.3	0.7	0.9
Average weekly fortified wine intake	0.4	0.5	0.7	0.6	0.6	0.8	0.9	0.5
Maternal smoking around birth	0.8	1.1	3.1	-1.8	-0.9	0.5	1.1	0.5
Fed-up feelings	2.6	4.7	9.3	-2.5	-3.0	-2.2	1.0	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	1.4	1.8	4.7	-2.2	-2.1	-0.2	-0.4	0.3
Relative age voice broke	0.1	0.2	0.6	-0.4	0.1	0.1	-0.2	-0.8
Taking other prescription medications	0.9	1.4	2.8	-1.3	-1.7	0.4	0.8	1.4
Age when periods started (menarche)	0.4	1.0	3.4	-0.5	-0.8	-1.9	-0.9	0.2
Bilateral oophorectomy (both ovaries removed)	0.8	1.0	2.7	-1.7	-1.0	-0.4	-0.1	0.9
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	0.6	-0.1	-0.8	-0.7	0.2	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.4	-1.2	-0.5	0.5	0.9	0.4
Qualifications: CSEs or equivalent	0.0	0.1	0.3	-0.5	-0.1	-0.1	0.1	0.0
Serious illness, injury or assault to yourself	0.2	0.3	1.0	-1.0	-0.6	0.1	0.3	0.1
High blood pressure	1.8	5.1	18.8	-0.8	1.3	4.3	1.8	1.1
Hayfever, allergic rhinitis or eczema	0.4	0.9	2.1	-0.9	0.7	-0.4	1.4	1.0
Multivitamins +/- minerals	0.2	0.3	0.4	-0.7	-0.6	-0.6	0.5	-0.1
Stomach or abdominal pain in last month	0.3	0.4	1.3	-0.5	-0.3	-1.1	0.4	0.2
Supplements: Glucosamine	1.0	1.3	2.9	1.2	1.7	-0.1	-0.1	-1.5
Diverticular disease/diverticulitis (self-reported)	1.4	1.6	3.9	1.4	2.0	1.0	-0.2	-1.1
Medication: Atenolol	0.5	0.6	2.4	-0.5	-0.2	0.4	1.6	0.5
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.2	0.3	-0.3	-0.6	0.6
Sitting height	0.4	2.8	5.3	-1.4	-1.6	-0.6	1.9	2.3
Chronic bronchitis/emphysema (father)	0.4	0.4	1.5	-0.6	-0.2	-0.2	1.2	0.3
High blood pressure (mother)	0.1	0.2	0.8	0.4	0.9	-0.3	0.1	-0.1
Body mass index (BMI)	0.7	2.9	6.8	-2.6	-1.6	0.8	1.6	1.3
Impedance of leg (left)	0.2	0.8	2.5	-0.2	-0.2	-1.6	-0.9	-0.7
Leg predicted mass (left)	0.6	3.0	6.2	-1.7	-1.2	1.0	2.5	1.9
Trunk fat mass	0.9	3.7	8.1	-2.8	-1.5	0.7	2.3	1.4
Waist circumference	1.6	5.8	11.2	-2.4	-1.8	0.9	3.4	2.8
Number of incorrect matches in round	0.5	0.9	2.8	1.7	0.5	-0.4	-0.8	-0.7
Past tobacco smoking	0.4	0.7	2.4	0.1	0.1	-1.6	-0.9	0.2
Alcohol usually taken with meals	2.8	4.6	9.3	3.1	3.0	1.0	-1.0	-1.6
Nervous feelings	0.2	0.4	0.6	0.8	0.8	0.7	0.6	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.9	1.4	4.0	-0.4	-0.5	2.0	-1.3	-0.9
Hearing difficulty/problems with background noise	0.4	0.7	2.2	0.6	-0.0	1.5	-0.8	0.2
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	0.3	-0.6	-0.3	-1.1	0.7
Had menopause	2.4	3.0	6.9	2.6	2.3	0.3	-1.2	-1.0
Had other major operations	0.3	0.4	0.7	-0.4	0.2	0.6	-0.8	-0.8
Forced vital capacity (FVC)	0.5	1.8	4.1	0.6	-0.2	1.0	2.0	1.8
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.5	1.0	-0.7	-1.0	-0.8	0.5	0.4
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.4	0.6	0.6	-0.6	-0.3	0.1
Qualifications: None of the above	0.2	0.4	1.6	-0.2	0.3	-0.3	-1.3	-0.2
Financial difficulties in last 2 years	1.9	2.5	4.7	-2.2	-1.9	1.5	-0.4	1.3
Mouth/teeth dental problems	1.2	1.8	5.5	0.9	1.5	2.4	0.2	-0.4
Heart attack	1.9	2.5	5.4	2.3	1.7	1.9	0.4	0.1
Allergy	0.6	1.4	2.6	1.6	0.2	-0.9	-1.4	-1.3
Pain all over the body in last month	2.0	2.1	4.8	-0.9	-1.4	-2.2	1.1	1.4
Diabetes (self-reported)	1.8	2.8	3.9	-1.5	-1.5	-2.0	1.7	1.8
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	2.7	-1.6	-0.2	-0.4	1.6	0.4
Medication: Ramipril	2.0	2.5	4.5	1.9	1.7	2.1	1.4	-0.0
Medication: Simvastatin	0.9	1.3	3.1	1.8	1.4	0.9	0.7	0.5
Fluid intelligence score	0.3	0.6	1.5	-0.7	-0.7	-0.8	1.2	0.2
Illnesses of siblings	0.9	1.2	3.9	0.4	0.5	-0.7	-1.2	-2.0
Neuroticism score	0.0	0.1	0.2	-0.0	-0.4	0.1	-0.5	0.2
Weight	0.9	4.2	6.5	-2.6	-1.8	0.7	2.5	2.2
Impedance of arm (right)	0.1	0.4	0.6	0.7	0.8	-0.3	0.3	-0.7
Arm fat percentage (right)	0.8	3.0	6.1	-2.5	-1.4	0.7	2.2	1.2
Trunk fat-free mass	0.3	1.6	3.8	-0.4	-0.6	0.9	1.6	2.0
Hip circumference	0.2	0.9	2.3	-0.9	-0.2	1.5	1.1	0.6
Time employed in main current job	0.1	0.1	0.3	-0.2	-0.6	-0.2	-0.2	0.2
Alcohol intake versus 10 years previously	0.5	0.7	2.2	-0.4	0.0	1.5	-0.5	-0.9
Father’s age at death	1.8	2.4	6.3	2.5	1.4	-1.2	-1.4	-0.7
Worrier / anxious feelings	2.0	3.8	6.9	2.6	2.1	1.6	-1.3	-2.0
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	2.8	-1.2	-1.6	-1.7	0.4	-0.3
Falls in the last year	0.3	0.5	1.8	-0.2	0.2	1.3	-0.7	0.0
Hair/balding pattern: Pattern 3	0.7	1.0	2.5	-0.5	-0.5	0.3	1.6	1.4
Number of live births	2.2	3.1	4.9	-2.1	-2.2	-1.1	-0.6	2.2
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	4.8	0.6	-0.3	0.8	2.2	1.9
Pulse rate	0.9	1.5	3.8	0.8	0.4	1.3	2.0	-1.0
Happiness	0.8	1.0	2.1	-0.5	-1.2	-1.4	-0.9	0.4
Noisy workplace	1.0	1.3	2.3	1.1	0.9	-0.9	-1.5	-1.1
Qualifications: A levels/AS levels or equivalent	0.5	1.0	3.8	-0.0	-0.5	-0.9	2.0	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.4	1.4	0.5	0.2	0.3	-1.2	-0.4
Mouth/teeth dental problems: Dentures	2.0	3.3	6.1	-1.9	-2.2	-2.5	-0.5	1.5
Asthma	1.2	2.3	5.3	-2.3	-1.8	0.8	-0.3	1.6
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	2.9	0.8	0.6	-0.3	-0.4	-1.7
Medication: Cholesterol lowering	1.0	1.5	4.2	0.6	0.4	2.0	1.5	0.8
Depression (self-reported)	0.3	0.4	0.7	-0.4	-0.7	0.4	-0.8	0.6
Medication: Lansoprazole	1.1	1.2	2.0	-0.9	-1.2	1.2	0.6	1.4
Prospective memory result	2.0	2.5	6.3	1.0	1.1	2.5	-1.2	-1.5
Lung cancer (father)	0.4	0.4	0.9	0.4	-0.3	-0.5	0.8	1.0
Illnesses of mother	0.6	0.7	1.4	-0.2	-0.9	1.2	0.7	-0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	2.6	0.7	-0.1	-0.3	1.6	1.2
Pulse wave Arterial Stiffness index	1.7	1.9	4.0	-1.5	-1.5	0.7	2.0	0.8
Impedance of arm (left)	0.0	0.2	0.4	-0.1	0.3	-0.6	0.6	-0.4
Arm fat mass (right)	0.7	2.7	4.8	-2.2	-1.4	0.8	2.1	1.4
Trunk predicted mass	0.3	1.5	3.6	-0.3	-0.5	0.9	1.7	1.9
Standing height	0.2	1.5	3.9	0.2	-0.3	-0.1	1.9	2.0
Length of working week for main job	0.4	0.5	1.5	-1.2	-0.5	-0.3	0.8	0.1
Exposure to tobacco smoke at home	2.1	2.4	5.0	-1.2	-1.4	-2.2	0.8	1.7
Breastfed as a baby	0.9	1.2	2.5	0.9	1.3	0.3	-1.6	-0.8
Tense / ‘highly strung’	0.5	0.9	3.9	-0.1	0.5	2.0	-0.4	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.0	0.3	-0.3	0.6	-0.7	1.0
Hair/balding pattern: Pattern 4	0.2	0.6	2.5	-0.3	0.2	1.6	0.3	-0.4
Birth weight of first child	0.7	1.3	2.4	-1.0	-0.7	-0.8	1.5	1.5
Peak expiratory flow (PEF)	0.3	0.8	2.9	0.6	0.3	1.7	0.6	-0.0
Pulse wave reflection index	2.6	3.2	8.2	-2.9	-2.3	-0.1	1.6	0.6
Ever highly irritable/argumentative for 2 days	0.2	0.2	0.8	-0.5	-0.1	0.1	-0.9	0.2
Loud music exposure frequency	1.3	1.4	2.3	1.1	1.3	-0.9	-1.0	-1.5
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	4.1	-0.3	-0.7	-0.3	2.0	0.8
Mouth/teeth dental problems: Bleeding gums	1.0	1.3	3.8	-1.9	-0.8	-1.3	-0.5	0.0
Blood clot in the leg (DVT)	0.3	0.3	1.5	0.2	0.2	0.1	-1.2	-0.4
Medication: Paracetamol	0.7	1.2	1.8	-1.2	-1.1	-0.3	1.2	1.3
Headache pain in last month	0.1	0.1	0.5	-0.2	0.0	0.0	0.4	-0.7
Medication for cholesterol, blood pressure or diabetes	1.4	2.4	8.8	-1.0	-1.3	-3.0	-0.4	-0.5
Glaucoma (self-reported)	0.3	0.4	1.0	-0.6	-0.7	-1.0	0.1	0.1
Gout (self-reported)	0.3	0.4	1.4	-1.2	-0.5	0.3	-0.1	-0.2
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	-0.2	0.2	-0.4	-0.4	0.2
Medication: Amlodipine	0.3	0.4	1.1	0.3	0.6	1.0	-0.2	0.5
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.7	-1.9	-1.0	0.1	-1.4	0.4
Birth weight	2.4	5.2	8.4	-2.9	-2.0	-0.4	2.5	2.8
Chronic bronchitis/emphysema (mother)	0.6	0.8	3.2	0.3	0.0	-0.3	-1.8	-0.6
High blood pressure (siblings)	1.0	1.4	3.2	1.4	1.1	1.8	-0.1	0.8
Forced vital capacity (FVC), Best measure	0.2	0.8	1.9	0.8	-0.1	0.0	1.4	1.1
Body fat percentage	0.8	3.2	9.0	-3.0	-1.5	0.3	1.9	1.0
Leg fat percentage (right)	0.7	2.4	7.5	-2.7	-1.5	-0.5	1.1	1.0
Arm fat-free mass (right)	0.4	1.9	3.4	-1.4	-1.0	0.4	1.7	1.8
Exposure to tobacco smoke outside home	1.0	1.4	3.0	-1.4	-1.7	-0.4	0.1	1.3
Comparative body size at age 10	0.6	1.6	4.2	1.0	0.9	2.1	-1.0	-1.1
Number of full brothers	3.0	3.8	7.6	-2.6	-2.0	-0.5	0.9	2.8
Worry too long after embarrassment	0.2	0.4	1.4	1.2	0.3	0.4	-0.2	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.1	-0.2	-0.6	1.5	0.1	1.2
Wheeze or whistling in the chest in last year	3.9	7.0	12.8	-3.6	-3.0	1.2	2.1	2.7
Number of children fathered	0.8	1.0	2.0	1.4	1.2	0.3	-0.5	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	0.9	0.9	0.7	0.5	-1.0	-0.4
Age at first live birth	1.6	2.8	5.9	2.4	1.7	1.1	1.8	-1.0
Pulse wave peak to peak time	1.5	1.8	3.8	1.5	1.4	-0.8	-2.0	-0.6
Health satisfaction	0.6	0.8	1.9	-0.7	-0.7	0.9	-1.4	0.4
Shortness of breath walking on level ground	0.5	0.6	1.2	-0.8	-1.1	-0.6	-0.0	1.0
Qualifications: College or University degree	0.5	1.6	3.8	1.9	1.3	-1.1	-0.4	-1.1
Eye problems/disorders: None of the above	1.2	1.4	3.1	-0.5	-0.7	1.8	1.7	0.6
Mouth/teeth dental problems: Loose teeth	0.1	0.2	0.5	0.1	-0.5	0.7	-0.1	-0.3
Emphysema/chronic bronchitis	2.6	3.0	4.8	-2.1	-2.2	-0.9	0.3	2.2
Medication for pain relief, constipation, heartburn	0.7	1.3	3.5	0.8	0.9	-0.4	-1.9	-1.2
Neck or shoulder pain in last month	0.3	0.4	1.7	-0.4	0.3	1.3	0.1	-0.2
Medication: Blood pressure	2.3	4.0	14.3	0.7	1.5	3.8	1.6	0.8
Angina (self-reported)	0.0	0.1	0.2	-0.0	-0.3	0.2	-0.0	0.4
Migraine (self-reported)	0.3	0.3	1.1	-1.1	-0.2	-0.7	0.1	-0.2
Medication: Ibuprofen	1.0	1.2	2.9	1.0	1.1	1.0	0.2	-1.7
Medication: Allopurinol	0.5	0.6	1.3	-1.0	-0.3	0.8	1.1	0.3
Medication: Omeprazole	1.6	1.9	5.2	2.3	1.6	1.2	0.0	-0.6
Medication: Seretide 50 evohaler	0.8	1.0	2.1	-0.7	-0.6	0.4	-1.5	-1.3
Mean time to correctly identify matches	1.4	2.7	5.8	2.4	2.2	0.6	-1.0	-1.1
Heart disease (mother)	1.0	1.2	3.4	0.9	1.9	-1.2	-0.4	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.0	1.7	-1.2	-0.7	0.5	1.1	1.3
Whole body fat mass	1.0	4.0	8.6	-2.9	-1.6	0.8	2.5	1.4
Leg fat mass (right)	1.1	4.2	9.4	-3.1	-1.8	0.3	2.3	1.8
Arm predicted mass (right)	0.3	1.4	2.9	-1.0	-0.7	0.8	1.7	1.5
Pulse rate, automated reading	0.9	3.1	9.9	-0.3	0.1	3.1	2.3	-0.2
Alcohol intake frequency.	0.2	0.4	1.4	-1.2	-0.6	0.4	0.5	0.2
Comparative height size at age 10	0.4	2.4	7.1	1.3	1.3	2.7	1.1	0.4
Number of full sisters	1.2	1.5	3.9	-1.3	-2.0	-1.1	0.3	0.9
Suffer from ‘nerves’	0.5	0.8	3.2	-0.5	-0.3	0.4	0.7	1.8
Overall health rating	0.2	0.3	1.0	-0.7	-0.4	1.0	-0.2	0.2
Chest pain or discomfort	0.8	1.2	2.6	-0.8	-1.6	-0.4	0.9	1.3
Had major operations	1.0	1.1	4.0	0.7	0.3	2.0	1.0	0.2
Age at last live birth	0.9	1.4	2.9	1.6	0.8	0.3	1.7	-0.7
Family relationship satisfaction	0.7	0.8	3.0	-1.7	-0.6	0.7	-0.3	0.4
Leg pain on walking	0.5	0.7	2.4	0.3	0.1	-1.6	-0.7	0.6
Qualifications: NVQ or HND or HNC or equivalent	0.6	0.7	1.3	-1.1	-0.8	-0.9	0.2	1.0
Commuting to job workplace: Car/motor vehicle	1.6	1.9	3.5	-1.9	-1.8	-0.9	-0.7	1.3
Illness, injury, bereavement, stress in last 2 years	1.2	1.5	2.7	1.1	1.3	-1.7	1.3	-0.3
Medication: Aspirin	1.3	1.7	5.4	-0.3	-0.5	0.5	1.6	2.3
Supplements: Vitamin C	1.4	1.6	3.0	1.6	1.2	-0.5	-0.8	-1.7
Knee pain experienced in last month	0.2	0.3	0.5	0.6	0.4	-0.7	-0.5	0.2
Hypertension (Self-reported)	1.6	4.4	15.2	-0.9	1.0	3.9	1.8	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.2	2.3	-1.0	-0.4	0.8	1.5	1.5
Illnesses of father: Heart disease	0.1	0.2	0.3	0.5	0.4	0.5	-0.2	-0.6
Illnesses of siblings: Diabetes	3.3	4.1	5.2	-2.2	-2.2	-1.1	2.0	2.3
Smoking status: Previous	0.6	0.9	3.2	-0.7	-0.4	1.8	0.9	-0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.8	-0.3	0.2	0.6	1.7	0.9
Whole body fat-free mass	0.4	2.4	4.3	-1.2	-1.0	0.9	2.1	2.1
Leg fat-free mass (right)	0.7	4.0	7.3	-2.1	-1.6	1.0	2.7	2.1
Arm fat percentage (left)	0.9	3.7	8.0	-2.8	-1.6	0.4	2.4	1.4
Average weekly red wine intake	0.3	0.4	0.8	0.6	0.9	0.9	-0.0	-0.2
Handedness (chirality/laterality): Left-handed	2.0	2.5	8.0	-0.7	-1.6	-2.8	-0.5	1.0
Mood swings	1.3	2.4	5.9	-2.2	-2.4	-0.2	-0.7	0.6
Loneliness, isolation	2.9	3.9	9.9	-3.1	-2.7	-0.2	-0.3	1.6
Long-standing illness, disability or infirmity	2.3	3.5	5.9	-2.4	-2.3	0.1	0.6	2.4
Ever had bowel cancer screening	0.2	0.3	1.1	-0.2	0.1	1.1	-0.2	0.1
Diabetes diagnosed by doctor	1.9	3.1	4.6	-1.9	-1.6	-1.0	2.1	1.9
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.8	-0.9	-0.1	-0.3	-0.4	-0.1
Friendships satisfaction	1.6	2.0	4.9	-2.2	-1.8	-0.4	-0.1	1.4
Qualifications: nursing, teaching	1.2	1.8	3.0	1.7	1.4	1.5	-0.4	-1.2
Commuting to job workplace: Walk	1.2	1.3	2.2	-0.6	-0.8	-1.4	1.5	1.2
Eye problems/disorders: Cataract	2.2	2.5	8.2	0.9	1.0	-0.6	-2.9	-1.5
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.8	1.2	0.5	1.7	0.4	-1.0
Medication for cholesterol	0.3	0.4	1.4	0.6	0.6	0.2	-0.1	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.0	-1.4	-1.7	-0.2	1.1	0.6
Back pain experienced in last month	1.0	1.5	3.1	-1.8	-1.3	-0.9	-0.8	1.2
Mineral and other dietary supplements	0.4	0.6	1.1	-0.8	-1.0	-0.1	-0.4	1.1
Breast cancer (self-reported)	0.1	0.1	0.3	0.5	0.1	-0.1	0.3	0.4
Asthma (self-reported)	1.1	2.3	5.2	-2.3	-1.7	0.7	-0.6	1.5
Osteoporosis (self-reported)	1.3	1.6	8.0	0.1	-0.0	-2.8	-0.2	-0.2
Osteoarthritis (self-reported)	1.1	1.5	3.9	-0.7	-0.5	-2.0	-1.6	-0.2
Medication: Aspirin	1.6	2.1	6.6	-0.7	-0.8	0.2	1.6	2.6
Medication: Gliclazide	2.1	2.4	3.8	-1.9	-1.5	-0.7	1.2	2.0
Illnesses of father: None of the above (group 1)	0.5	0.6	0.9	-0.7	-0.9	-1.0	-0.4	0.8
Smoking status: Current	0.1	0.1	0.4	0.1	-0.1	0.0	0.4	0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.5	1.1	0.1	-0.4	0.8	1.2
Whole body water mass	0.4	2.2	4.3	-1.1	-1.0	0.9	2.1	2.0
Leg predicted mass (right)	0.7	4.0	7.2	-2.1	-1.7	1.0	2.7	2.1
Arm fat mass (left)	0.9	3.6	7.0	-2.6	-1.7	0.6	2.3	1.6
Number of self-reported non-cancer illnesses	0.9	1.5	4.2	-1.5	-0.4	2.0	0.1	1.0
Average weekly champagne plus white wine intake	0.9	1.2	4.1	2.0	1.1	0.3	1.0	0.1
Miserableness	0.9	1.5	3.4	-0.8	-1.0	-1.9	-1.5	-0.4
Guilty feelings	0.3	0.4	0.9	0.9	0.3	-0.5	-0.8	-0.3
Wears glasses or contact lenses	1.2	1.4	2.6	1.6	1.3	1.5	0.7	0.3
Ever taken oral contraceptive pill	0.5	0.6	2.5	0.5	0.2	1.6	-0.1	-0.4
Hearing aid user	0.7	0.8	1.1	-0.9	-0.5	-1.0	-0.8	1.1
Mother’s age at death	4.6	5.7	11.7	3.4	2.6	0.6	-2.2	-2.2
Financial situation satisfaction	0.3	0.4	0.6	-0.7	-0.5	0.8	-0.8	0.0
Tinnitus: Yes, now most or all of the time	0.7	0.8	2.8	0.4	-0.9	-1.7	-0.5	0.1
Commuting to job workplace: Public transport	0.3	0.4	0.7	-0.6	-0.5	-0.6	0.9	0.4
Eye problems/disorders: Glaucoma	1.1	1.3	5.5	-0.4	-0.8	-2.4	-0.3	0.6
Medication: Blood pressure	0.5	1.0	2.6	-1.1	-0.7	0.1	0.7	1.6
Pain type(s) experienced in last month: Hip pain	0.9	1.2	2.4	-1.6	-1.0	-1.4	-0.7	0.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.6	0.8	0.7	0.6	0.0	-0.7
High cholesterol (Self-reported)	0.9	1.7	4.8	-0.2	-0.6	-0.3	2.2	1.7
Medication: Bendroflumethiazide	1.0	1.5	4.2	0.3	0.8	2.0	1.1	1.2
Medication: Paracetamol	0.9	1.4	2.3	-1.5	-1.4	-0.6	0.9	1.3
Medication: Lisinopril	0.7	0.9	2.6	0.5	0.8	1.6	0.7	0.8
Medication: Atorvastatin	0.9	1.1	2.7	-0.8	-0.8	-0.5	1.0	1.7
Illnesses of father: High blood pressure	1.5	1.9	4.9	0.7	0.9	2.2	-1.6	-0.8
Alcohol drinker status: Never	0.2	0.3	0.6	0.4	0.6	0.0	-0.8	-0.6
Ever smoked	0.3	0.6	2.5	0.5	0.2	1.6	0.2	-0.5
Basal metabolic rate	0.5	2.8	4.8	-1.6	-1.3	0.9	2.2	2.1
Leg fat percentage (left)	1.0	3.5	10.7	-3.3	-1.9	-0.4	1.2	1.1
Arm fat-free mass (left)	0.3	1.6	3.2	-1.0	-1.0	0.5	1.6	1.8
Number of operations (self-reported)	0.9	1.3	3.6	0.6	0.9	1.9	-1.2	-0.6
Average weekly beer plus cider intake	4.1	5.9	12.3	-2.1	-2.9	-3.5	0.7	2.0
Irritability	0.0	0.1	0.1	-0.2	-0.2	0.4	-0.3	-0.3
Risk taking	0.1	0.2	0.6	0.2	-0.4	0.0	-0.8	-0.3
Ever had prostate specific antigen (PSA) test	1.6	1.8	2.9	1.7	1.6	1.0	-1.2	-1.1
Fractured/broken bones in last 5 years	0.4	0.6	1.8	0.4	0.5	-0.6	-0.6	-1.3
Age started oral contraceptive pill	0.3	0.4	1.1	1.1	0.7	0.2	-0.4	0.2
Diastolic blood pressure, automated reading	1.3	4.0	12.3	1.0	2.1	3.5	1.3	-0.8
Ever depressed for a whole week	1.2	1.4	2.9	-1.1	-0.9	-0.8	1.7	1.2
Unable to work because of sickness or disability	1.3	1.7	3.3	-1.1	-1.3	-0.0	1.8	1.5
Commuting to job workplace: Cycle	0.2	0.3	0.6	0.4	0.4	0.8	0.3	-0.7
Myopia	0.2	0.3	0.7	0.8	-0.3	-0.2	-0.1	-0.8
Vascular/heart problems diagnosed by doctor	1.3	3.5	13.8	0.2	-1.4	-3.7	-1.0	-0.8
Cholesterol lowering medication	0.5	0.8	1.5	0.6	0.2	-0.8	1.1	1.2
Medication: Omeprazole (e.g. Zanprol)	1.2	1.5	3.3	1.8	1.5	1.1	-0.2	-0.7
Pain experienced in last month	0.3	0.6	1.1	0.9	1.0	0.5	0.7	-0.5
Supplements: Calcium	1.5	1.7	4.5	0.7	1.0	0.4	-1.4	-2.1
Basal cell carcinoma (self-reported)	2.4	2.8	5.2	1.5	0.9	1.0	-2.2	-2.3
Heart attack/myocardial infarction (self-reported)	2.0	2.6	6.3	2.5	1.8	1.7	0.3	0.2
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	2.8	0.5	0.4	0.0	-1.7	-0.7
Heart disease (siblings)	0.2	0.2	0.6	-0.2	-0.2	-0.1	0.8	0.5
Alcohol drinker status: Previous	1.4	1.6	3.0	-1.5	-0.8	1.1	1.7	0.9
Pack years of smoking	2.6	3.8	7.5	-2.7	-2.7	-1.1	0.7	1.7
Impedance of whole body	0.1	0.5	1.7	-0.0	0.2	-1.3	-0.4	-0.9
Leg fat mass (left)	1.3	5.3	12.2	-3.5	-2.2	0.2	2.3	1.9
Arm predicted mass (left)	0.4	1.8	3.5	-1.2	-1.1	0.5	1.6	1.9