Hub : Genes

CBWD2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells EBV-transformed lymphocytes 0.570 0.1240 6.4e-04 0.049 NA 0.014 NA 0.030 1.1e-02 NA 1.1e-01 NA 3.6e-02
2 GTEx Cells Transformed fibroblasts 0.164 0.0470 1.9e-05 0.141 NA 0.128 NA 0.142 1.1e-10 NA 8.4e-10 NA 9.2e-11
3 GTEx Thyroid 0.328 0.0640 5.7e-07 0.147 NA 0.124 NA 0.151 2.5e-11 NA 1.1e-09 NA 1.2e-11
4 METSIM Adipose 0.196 0.0492 1.4e-08 0.014 0.084 0.095 0.094 0.083 2.7e-03 1.6e-12 5.4e-14 6.9e-14 2.2e-12
5 ROSMAP Brain Pre-frontal Cortex 0.186 0.0473 9.2e-09 0.100 0.075 0.105 0.103 0.102 7.9e-13 6.3e-10 2.4e-13 3.7e-13 4.8e-13

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.1 0.1 0.2 -0.4 -0.0 -0.4 -0.2 -0.1
Bipolar Disorder or Schizophrenia 0.8 1.9 3.4 -1.6 -1.4 -1.1 0.6 1.8
Depressed Affect (Nagel 2018) 1.2 2.5 4.7 -1.9 -2.2 -1.9 -0.6 0.6
Depression (Nagel 2018) 1.3 2.0 5.0 -2.2 -1.9 -0.5 -1.1 0.0
Intelligence (Savage-Jansen 2018) 0.7 2.3 4.3 -1.2 -1.4 -1.6 2.1 1.1
Neuroticism (Nagel 2018) 0.1 0.2 0.6 -0.1 -0.4 -0.3 -0.7 0.2
Schizophrenia (2018) 1.4 3.0 6.6 -1.8 -1.8 -1.1 1.0 2.6
Schizophrenia vs Biploar Disorder 0.5 0.7 1.3 -0.6 -1.1 -1.0 0.4 0.9
Worry (Nagel 2018) 1.0 2.1 4.1 1.7 1.7 2.0 -0.5 -0.4
Alzheimer’s Disease (in mother) 2.1 2.5 5.4 -2.3 -1.9 -0.9 1.0 1.2
Alzheimer’s Disease (in father) 1.2 1.3 3.4 1.8 1.5 0.5 0.6 -0.8
Alzheimer’s Disease (including proxy) 0.3 0.4 1.2 -0.7 -0.6 -0.4 1.1 0.2
Crohns Disease (2017) 1.1 2.4 4.5 -2.1 -1.0 -2.0 0.9 1.3
Irritable Bowel Disease (IBD) 0.9 2.2 7.3 -2.7 -1.2 -1.0 0.6 0.9
Ulcerative Colitis (UC) 0.6 1.0 3.6 -1.9 -0.4 1.1 -0.5 -0.2
Major Depression (MDD) 0.8 0.9 2.0 -1.0 -1.0 -1.4 0.1 0.9
Reaction Time 0.4 0.7 2.0 1.1 1.4 0.2 -0.2 -0.5
Verbal and Numeric Reasoning (VNR) 0.2 0.6 0.8 -0.7 -0.8 -0.9 0.9 0.2
Breast Cancer 0.1 0.3 0.7 -0.6 -0.2 0.8 0.5 -0.4
Ovarian Cancer 1.5 2.0 5.1 2.3 1.7 0.4 -1.2 -0.6
Prostate Cancer 0.6 0.8 2.9 -1.7 -0.9 0.2 -0.5 0.3
Age at First Birth 1.1 1.6 3.7 1.9 1.5 -1.2 0.7 -0.4
Bipolar Disorder (2011) 2.0 2.0 3.2 -1.8 -1.2 -0.5 1.7 1.5
Body Mass Index (BMI) (2010) 0.4 0.6 1.3 -0.7 -0.1 1.2 -0.2 1.0
Coronary Artery Disease (CAD) 1.9 2.3 4.9 -1.6 -0.8 1.4 1.2 2.2
Crohns Disease (2012) 1.3 2.1 3.7 -1.8 -1.3 -1.9 1.0 0.9
Mean Putamen Volume 0.2 0.2 0.8 -0.4 -0.1 0.4 0.3 0.9
Fasting Glucose 0.6 0.7 1.6 1.0 0.7 1.2 0.0 -0.8
HbA1C 1.9 2.2 5.8 1.4 1.4 2.4 -0.5 -0.9
HDL Cholesterol 0.4 0.7 2.2 0.0 -0.4 -0.8 1.5 0.8
LDL Cholesterol 0.5 0.8 2.7 0.7 -0.0 -1.6 0.5 0.7
Lupus 0.2 0.3 0.9 -0.4 0.2 0.1 -0.9 -0.5
Neuroticism (2016) 2.7 3.9 7.0 -2.6 -2.6 0.2 1.3 2.0
Primary Biliary Cirrhosis 1.4 2.1 5.6 -1.9 -0.5 0.6 2.4 0.6
Rheumatoid Arthritis 0.8 1.2 2.6 -1.6 -1.2 1.0 0.8 0.1
Schizophrenia (2014) 1.0 2.1 3.6 -1.4 -1.6 -1.4 1.0 1.9
Triglycerides 0.1 0.2 0.4 0.4 0.5 0.5 -0.1 0.6
Type 2 Diabetes (T2D) (2012) 0.8 0.9 2.3 -1.5 -0.6 1.1 -0.3 0.9
Ulcerative Colitis 0.4 0.6 1.9 -1.4 -0.1 0.6 0.6 -0.5
Blood Eosinophil Count 0.3 2.1 3.7 -1.9 -1.5 -1.4 0.6 1.5
Blood Platelet Count 0.1 1.5 3.0 -1.7 -1.7 -0.5 0.9 -0.5
Blood Red Count 0.6 5.7 13.8 -3.7 -2.6 1.3 2.5 0.5
Blood White Count 1.2 8.6 20.8 -4.6 -2.9 -2.3 -2.6 -1.3
Heel T-Score 0.4 3.1 11.2 0.8 0.9 3.4 0.7 -1.6
BMI 1.0 6.0 15.1 -3.9 -2.5 0.9 1.8 2.0
Height 0.2 4.5 15.1 0.8 -0.6 0.1 3.9 2.6
Waist Hip Ratio (WHR) 2.2 9.8 27.5 -1.6 -2.4 -0.6 5.2 3.6
Systolic Blood Pressure 1.3 6.7 21.4 1.4 2.5 4.6 1.9 -0.4
Smoking Status 0.5 1.1 3.2 -0.2 -0.2 1.4 1.8 0.7
Allergy or Eczema 0.4 1.0 1.7 -1.1 0.6 -1.0 1.0 1.3
Cardiovascular Disease 1.9 6.3 11.7 -1.1 -0.2 3.3 3.4 2.8
Hypothyroidism (self reported) 0.0 0.0 0.0 -0.2 0.1 -0.2 0.0 0.2
Respiratory disease 1.3 3.0 6.5 -2.5 -2.2 -0.2 -0.6 1.8
Type 2 Diabetes (T2D) (2018) 1.1 2.1 2.7 -0.8 -1.5 -1.6 1.6 1.4
Lung FEV1/FVC ratio 0.1 0.3 0.7 -0.3 0.0 0.9 0.7 -0.1
Lung FVC 0.5 2.6 6.5 2.5 1.5 0.9 -1.8 -0.6
Neuroticism 0.2 0.4 1.7 0.1 -0.1 0.3 -1.3 0.4
Chronotype (morning person) 0.3 0.7 1.2 -1.1 0.5 0.9 1.1 0.2
Hair Pigment 0.0 0.6 1.7 -0.4 -0.0 0.6 -1.3 -0.8
Tanning 0.2 2.1 4.0 -2.0 -0.7 1.9 0.1 1.5
Hand grip strength (left) 0.8 2.2 3.6 1.6 1.5 1.0 -1.4 -1.9
Number of treatments/medications taken 1.2 2.2 3.1 -1.5 -1.3 1.0 1.8 1.6
Average weekly spirits intake 2.6 3.2 8.6 -2.9 -2.1 -1.3 -0.7 0.8
Sensitivity / hurt feelings 0.7 1.2 2.5 -1.0 -1.3 -0.9 0.4 1.6
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.6 -1.1 -1.3 0.7 -0.2 0.1
Hearing difficulty/problems: Yes 0.3 0.5 1.8 -0.2 -0.8 -0.3 -1.3 -0.4
Relative age of first facial hair 0.3 0.7 2.3 0.4 -0.0 -1.5 -0.3 -1.0
Other serious medical condition/disability diagnosed by doctor 3.8 4.9 8.9 -3.0 -2.5 -0.6 1.1 2.8
Ever used hormone-replacement therapy (HRT) 1.6 2.0 8.6 0.6 0.4 -0.2 -2.9 -0.8
Ever had hysterectomy (womb removed) 0.8 0.9 1.6 -0.8 -0.7 -1.2 -1.0 0.8
Systolic blood pressure, automated reading 0.9 2.5 5.3 1.8 2.0 2.3 0.1 -0.3
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 1.2 -0.4 -0.5 -0.6 0.5 1.1
Angina 0.1 0.1 0.2 0.4 0.2 0.4 -0.3 -0.1
Medication for hormone replacement therapy 0.8 0.8 2.9 -0.2 0.2 0.1 -1.7 -1.1
Vitamin and mineral supplements 0.5 0.7 1.6 0.2 0.5 1.3 0.3 1.2
Supplements: Zinc 0.7 0.8 1.8 0.6 0.8 1.0 -1.4 -0.2
Medication: Co-codamol 0.1 0.1 0.1 -0.3 -0.3 0.2 0.2 -0.2
Medication: Metformin 0.9 1.2 2.1 -1.0 -0.8 -0.8 1.5 1.3
Diabetes (father) 0.2 0.2 0.5 -0.7 -0.2 -0.6 -0.4 0.1
Diabetes (mother) 1.1 1.4 3.2 -0.7 -1.2 -1.8 0.6 1.3
Severe depression (siblings) 0.2 0.3 0.6 0.5 -0.4 -0.5 -0.7 -0.3
Pack years adult smoking proportion 3.1 4.7 9.1 -3.0 -2.9 -1.2 1.1 1.8
Impedance of leg (right) 0.3 1.2 2.9 0.8 0.6 -1.7 -1.2 -0.9
Leg fat-free mass (left) 0.6 3.1 6.1 -1.7 -1.2 1.0 2.5 1.9
Trunk fat percentage 0.7 2.8 7.5 -2.7 -1.4 0.4 1.9 0.9
Hand grip strength (right) 0.3 0.9 2.5 0.5 1.1 0.6 -0.3 -1.6
Townsend deprivation index at recruitment 1.6 2.3 4.2 -2.0 -2.0 0.2 1.6 0.9
Current tobacco smoking 0.2 0.4 0.8 -0.4 -0.6 -0.3 0.7 0.9
Average weekly fortified wine intake 0.4 0.5 0.7 0.6 0.6 0.8 0.9 0.5
Maternal smoking around birth 0.8 1.1 3.1 -1.8 -0.9 0.5 1.1 0.5
Fed-up feelings 2.6 4.7 9.3 -2.5 -3.0 -2.2 1.0 1.5
Frequency of unenthusiasm / disinterest in last 2 weeks 1.4 1.8 4.7 -2.2 -2.1 -0.2 -0.4 0.3
Relative age voice broke 0.1 0.2 0.6 -0.4 0.1 0.1 -0.2 -0.8
Taking other prescription medications 0.9 1.4 2.8 -1.3 -1.7 0.4 0.8 1.4
Age when periods started (menarche) 0.4 1.0 3.4 -0.5 -0.8 -1.9 -0.9 0.2
Bilateral oophorectomy (both ovaries removed) 0.8 1.0 2.7 -1.7 -1.0 -0.4 -0.1 0.9
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 0.6 -0.1 -0.8 -0.7 0.2 0.4
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.4 -1.2 -0.5 0.5 0.9 0.4
Qualifications: CSEs or equivalent 0.0 0.1 0.3 -0.5 -0.1 -0.1 0.1 0.0
Serious illness, injury or assault to yourself 0.2 0.3 1.0 -1.0 -0.6 0.1 0.3 0.1
High blood pressure 1.8 5.1 18.8 -0.8 1.3 4.3 1.8 1.1
Hayfever, allergic rhinitis or eczema 0.4 0.9 2.1 -0.9 0.7 -0.4 1.4 1.0
Multivitamins +/- minerals 0.2 0.3 0.4 -0.7 -0.6 -0.6 0.5 -0.1
Stomach or abdominal pain in last month 0.3 0.4 1.3 -0.5 -0.3 -1.1 0.4 0.2
Supplements: Glucosamine 1.0 1.3 2.9 1.2 1.7 -0.1 -0.1 -1.5
Diverticular disease/diverticulitis (self-reported) 1.4 1.6 3.9 1.4 2.0 1.0 -0.2 -1.1
Medication: Atenolol 0.5 0.6 2.4 -0.5 -0.2 0.4 1.6 0.5
Medication: Levothyroxine sodium 0.1 0.2 0.4 0.2 0.3 -0.3 -0.6 0.6
Sitting height 0.4 2.8 5.3 -1.4 -1.6 -0.6 1.9 2.3
Chronic bronchitis/emphysema (father) 0.4 0.4 1.5 -0.6 -0.2 -0.2 1.2 0.3
High blood pressure (mother) 0.1 0.2 0.8 0.4 0.9 -0.3 0.1 -0.1
Body mass index (BMI) 0.7 2.9 6.8 -2.6 -1.6 0.8 1.6 1.3
Impedance of leg (left) 0.2 0.8 2.5 -0.2 -0.2 -1.6 -0.9 -0.7
Leg predicted mass (left) 0.6 3.0 6.2 -1.7 -1.2 1.0 2.5 1.9
Trunk fat mass 0.9 3.7 8.1 -2.8 -1.5 0.7 2.3 1.4
Waist circumference 1.6 5.8 11.2 -2.4 -1.8 0.9 3.4 2.8
Number of incorrect matches in round 0.5 0.9 2.8 1.7 0.5 -0.4 -0.8 -0.7
Past tobacco smoking 0.4 0.7 2.4 0.1 0.1 -1.6 -0.9 0.2
Alcohol usually taken with meals 2.8 4.6 9.3 3.1 3.0 1.0 -1.0 -1.6
Nervous feelings 0.2 0.4 0.6 0.8 0.8 0.7 0.6 0.4
Frequency of tenseness / restlessness in last 2 weeks 0.9 1.4 4.0 -0.4 -0.5 2.0 -1.3 -0.9
Hearing difficulty/problems with background noise 0.4 0.7 2.2 0.6 -0.0 1.5 -0.8 0.2
Hair/balding pattern: Pattern 2 0.4 0.5 1.2 0.3 -0.6 -0.3 -1.1 0.7
Had menopause 2.4 3.0 6.9 2.6 2.3 0.3 -1.2 -1.0
Had other major operations 0.3 0.4 0.7 -0.4 0.2 0.6 -0.8 -0.8
Forced vital capacity (FVC) 0.5 1.8 4.1 0.6 -0.2 1.0 2.0 1.8
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.0 -0.7 -1.0 -0.8 0.5 0.4
Ever unenthusiastic/disinterested for a whole week 0.2 0.2 0.4 0.6 0.6 -0.6 -0.3 0.1
Qualifications: None of the above 0.2 0.4 1.6 -0.2 0.3 -0.3 -1.3 -0.2
Financial difficulties in last 2 years 1.9 2.5 4.7 -2.2 -1.9 1.5 -0.4 1.3
Mouth/teeth dental problems 1.2 1.8 5.5 0.9 1.5 2.4 0.2 -0.4
Heart attack 1.9 2.5 5.4 2.3 1.7 1.9 0.4 0.1
Allergy 0.6 1.4 2.6 1.6 0.2 -0.9 -1.4 -1.3
Pain all over the body in last month 2.0 2.1 4.8 -0.9 -1.4 -2.2 1.1 1.4
Diabetes (self-reported) 1.8 2.8 3.9 -1.5 -1.5 -2.0 1.7 1.8
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 2.7 -1.6 -0.2 -0.4 1.6 0.4
Medication: Ramipril 2.0 2.5 4.5 1.9 1.7 2.1 1.4 -0.0
Medication: Simvastatin 0.9 1.3 3.1 1.8 1.4 0.9 0.7 0.5
Fluid intelligence score 0.3 0.6 1.5 -0.7 -0.7 -0.8 1.2 0.2
Illnesses of siblings 0.9 1.2 3.9 0.4 0.5 -0.7 -1.2 -2.0
Neuroticism score 0.0 0.1 0.2 -0.0 -0.4 0.1 -0.5 0.2
Weight 0.9 4.2 6.5 -2.6 -1.8 0.7 2.5 2.2
Impedance of arm (right) 0.1 0.4 0.6 0.7 0.8 -0.3 0.3 -0.7
Arm fat percentage (right) 0.8 3.0 6.1 -2.5 -1.4 0.7 2.2 1.2
Trunk fat-free mass 0.3 1.6 3.8 -0.4 -0.6 0.9 1.6 2.0
Hip circumference 0.2 0.9 2.3 -0.9 -0.2 1.5 1.1 0.6
Time employed in main current job 0.1 0.1 0.3 -0.2 -0.6 -0.2 -0.2 0.2
Alcohol intake versus 10 years previously 0.5 0.7 2.2 -0.4 0.0 1.5 -0.5 -0.9
Father’s age at death 1.8 2.4 6.3 2.5 1.4 -1.2 -1.4 -0.7
Worrier / anxious feelings 2.0 3.8 6.9 2.6 2.1 1.6 -1.3 -2.0
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 2.8 -1.2 -1.6 -1.7 0.4 -0.3
Falls in the last year 0.3 0.5 1.8 -0.2 0.2 1.3 -0.7 0.0
Hair/balding pattern: Pattern 3 0.7 1.0 2.5 -0.5 -0.5 0.3 1.6 1.4
Number of live births 2.2 3.1 4.9 -2.1 -2.2 -1.1 -0.6 2.2
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 4.8 0.6 -0.3 0.8 2.2 1.9
Pulse rate 0.9 1.5 3.8 0.8 0.4 1.3 2.0 -1.0
Happiness 0.8 1.0 2.1 -0.5 -1.2 -1.4 -0.9 0.4
Noisy workplace 1.0 1.3 2.3 1.1 0.9 -0.9 -1.5 -1.1
Qualifications: A levels/AS levels or equivalent 0.5 1.0 3.8 -0.0 -0.5 -0.9 2.0 0.4
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.4 1.4 0.5 0.2 0.3 -1.2 -0.4
Mouth/teeth dental problems: Dentures 2.0 3.3 6.1 -1.9 -2.2 -2.5 -0.5 1.5
Asthma 1.2 2.3 5.3 -2.3 -1.8 0.8 -0.3 1.6
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 2.9 0.8 0.6 -0.3 -0.4 -1.7
Medication: Cholesterol lowering 1.0 1.5 4.2 0.6 0.4 2.0 1.5 0.8
Depression (self-reported) 0.3 0.4 0.7 -0.4 -0.7 0.4 -0.8 0.6
Medication: Lansoprazole 1.1 1.2 2.0 -0.9 -1.2 1.2 0.6 1.4
Prospective memory result 2.0 2.5 6.3 1.0 1.1 2.5 -1.2 -1.5
Lung cancer (father) 0.4 0.4 0.9 0.4 -0.3 -0.5 0.8 1.0
Illnesses of mother 0.6 0.7 1.4 -0.2 -0.9 1.2 0.7 -0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 0.9 2.6 0.7 -0.1 -0.3 1.6 1.2
Pulse wave Arterial Stiffness index 1.7 1.9 4.0 -1.5 -1.5 0.7 2.0 0.8
Impedance of arm (left) 0.0 0.2 0.4 -0.1 0.3 -0.6 0.6 -0.4
Arm fat mass (right) 0.7 2.7 4.8 -2.2 -1.4 0.8 2.1 1.4
Trunk predicted mass 0.3 1.5 3.6 -0.3 -0.5 0.9 1.7 1.9
Standing height 0.2 1.5 3.9 0.2 -0.3 -0.1 1.9 2.0
Length of working week for main job 0.4 0.5 1.5 -1.2 -0.5 -0.3 0.8 0.1
Exposure to tobacco smoke at home 2.1 2.4 5.0 -1.2 -1.4 -2.2 0.8 1.7
Breastfed as a baby 0.9 1.2 2.5 0.9 1.3 0.3 -1.6 -0.8
Tense / ‘highly strung’ 0.5 0.9 3.9 -0.1 0.5 2.0 -0.4 0.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.0 0.3 -0.3 0.6 -0.7 1.0
Hair/balding pattern: Pattern 4 0.2 0.6 2.5 -0.3 0.2 1.6 0.3 -0.4
Birth weight of first child 0.7 1.3 2.4 -1.0 -0.7 -0.8 1.5 1.5
Peak expiratory flow (PEF) 0.3 0.8 2.9 0.6 0.3 1.7 0.6 -0.0
Pulse wave reflection index 2.6 3.2 8.2 -2.9 -2.3 -0.1 1.6 0.6
Ever highly irritable/argumentative for 2 days 0.2 0.2 0.8 -0.5 -0.1 0.1 -0.9 0.2
Loud music exposure frequency 1.3 1.4 2.3 1.1 1.3 -0.9 -1.0 -1.5
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 4.1 -0.3 -0.7 -0.3 2.0 0.8
Mouth/teeth dental problems: Bleeding gums 1.0 1.3 3.8 -1.9 -0.8 -1.3 -0.5 0.0
Blood clot in the leg (DVT) 0.3 0.3 1.5 0.2 0.2 0.1 -1.2 -0.4
Medication: Paracetamol 0.7 1.2 1.8 -1.2 -1.1 -0.3 1.2 1.3
Headache pain in last month 0.1 0.1 0.5 -0.2 0.0 0.0 0.4 -0.7
Medication for cholesterol, blood pressure or diabetes 1.4 2.4 8.8 -1.0 -1.3 -3.0 -0.4 -0.5
Glaucoma (self-reported) 0.3 0.4 1.0 -0.6 -0.7 -1.0 0.1 0.1
Gout (self-reported) 0.3 0.4 1.4 -1.2 -0.5 0.3 -0.1 -0.2
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.2 -0.2 0.2 -0.4 -0.4 0.2
Medication: Amlodipine 0.3 0.4 1.1 0.3 0.6 1.0 -0.2 0.5
Medication: Ventolin 100micrograms inhaler 1.1 1.4 3.7 -1.9 -1.0 0.1 -1.4 0.4
Birth weight 2.4 5.2 8.4 -2.9 -2.0 -0.4 2.5 2.8
Chronic bronchitis/emphysema (mother) 0.6 0.8 3.2 0.3 0.0 -0.3 -1.8 -0.6
High blood pressure (siblings) 1.0 1.4 3.2 1.4 1.1 1.8 -0.1 0.8
Forced vital capacity (FVC), Best measure 0.2 0.8 1.9 0.8 -0.1 0.0 1.4 1.1
Body fat percentage 0.8 3.2 9.0 -3.0 -1.5 0.3 1.9 1.0
Leg fat percentage (right) 0.7 2.4 7.5 -2.7 -1.5 -0.5 1.1 1.0
Arm fat-free mass (right) 0.4 1.9 3.4 -1.4 -1.0 0.4 1.7 1.8
Exposure to tobacco smoke outside home 1.0 1.4 3.0 -1.4 -1.7 -0.4 0.1 1.3
Comparative body size at age 10 0.6 1.6 4.2 1.0 0.9 2.1 -1.0 -1.1
Number of full brothers 3.0 3.8 7.6 -2.6 -2.0 -0.5 0.9 2.8
Worry too long after embarrassment 0.2 0.4 1.4 1.2 0.3 0.4 -0.2 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 0.6 0.8 2.1 -0.2 -0.6 1.5 0.1 1.2
Wheeze or whistling in the chest in last year 3.9 7.0 12.8 -3.6 -3.0 1.2 2.1 2.7
Number of children fathered 0.8 1.0 2.0 1.4 1.2 0.3 -0.5 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.4 0.5 0.9 0.9 0.7 0.5 -1.0 -0.4
Age at first live birth 1.6 2.8 5.9 2.4 1.7 1.1 1.8 -1.0
Pulse wave peak to peak time 1.5 1.8 3.8 1.5 1.4 -0.8 -2.0 -0.6
Health satisfaction 0.6 0.8 1.9 -0.7 -0.7 0.9 -1.4 0.4
Shortness of breath walking on level ground 0.5 0.6 1.2 -0.8 -1.1 -0.6 -0.0 1.0
Qualifications: College or University degree 0.5 1.6 3.8 1.9 1.3 -1.1 -0.4 -1.1
Eye problems/disorders: None of the above 1.2 1.4 3.1 -0.5 -0.7 1.8 1.7 0.6
Mouth/teeth dental problems: Loose teeth 0.1 0.2 0.5 0.1 -0.5 0.7 -0.1 -0.3
Emphysema/chronic bronchitis 2.6 3.0 4.8 -2.1 -2.2 -0.9 0.3 2.2
Medication for pain relief, constipation, heartburn 0.7 1.3 3.5 0.8 0.9 -0.4 -1.9 -1.2
Neck or shoulder pain in last month 0.3 0.4 1.7 -0.4 0.3 1.3 0.1 -0.2
Medication: Blood pressure 2.3 4.0 14.3 0.7 1.5 3.8 1.6 0.8
Angina (self-reported) 0.0 0.1 0.2 -0.0 -0.3 0.2 -0.0 0.4
Migraine (self-reported) 0.3 0.3 1.1 -1.1 -0.2 -0.7 0.1 -0.2
Medication: Ibuprofen 1.0 1.2 2.9 1.0 1.1 1.0 0.2 -1.7
Medication: Allopurinol 0.5 0.6 1.3 -1.0 -0.3 0.8 1.1 0.3
Medication: Omeprazole 1.6 1.9 5.2 2.3 1.6 1.2 0.0 -0.6
Medication: Seretide 50 evohaler 0.8 1.0 2.1 -0.7 -0.6 0.4 -1.5 -1.3
Mean time to correctly identify matches 1.4 2.7 5.8 2.4 2.2 0.6 -1.0 -1.1
Heart disease (mother) 1.0 1.2 3.4 0.9 1.9 -1.2 -0.4 -0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.0 1.7 -1.2 -0.7 0.5 1.1 1.3
Whole body fat mass 1.0 4.0 8.6 -2.9 -1.6 0.8 2.5 1.4
Leg fat mass (right) 1.1 4.2 9.4 -3.1 -1.8 0.3 2.3 1.8
Arm predicted mass (right) 0.3 1.4 2.9 -1.0 -0.7 0.8 1.7 1.5
Pulse rate, automated reading 0.9 3.1 9.9 -0.3 0.1 3.1 2.3 -0.2
Alcohol intake frequency. 0.2 0.4 1.4 -1.2 -0.6 0.4 0.5 0.2
Comparative height size at age 10 0.4 2.4 7.1 1.3 1.3 2.7 1.1 0.4
Number of full sisters 1.2 1.5 3.9 -1.3 -2.0 -1.1 0.3 0.9
Suffer from ‘nerves’ 0.5 0.8 3.2 -0.5 -0.3 0.4 0.7 1.8
Overall health rating 0.2 0.3 1.0 -0.7 -0.4 1.0 -0.2 0.2
Chest pain or discomfort 0.8 1.2 2.6 -0.8 -1.6 -0.4 0.9 1.3
Had major operations 1.0 1.1 4.0 0.7 0.3 2.0 1.0 0.2
Age at last live birth 0.9 1.4 2.9 1.6 0.8 0.3 1.7 -0.7
Family relationship satisfaction 0.7 0.8 3.0 -1.7 -0.6 0.7 -0.3 0.4
Leg pain on walking 0.5 0.7 2.4 0.3 0.1 -1.6 -0.7 0.6
Qualifications: NVQ or HND or HNC or equivalent 0.6 0.7 1.3 -1.1 -0.8 -0.9 0.2 1.0
Commuting to job workplace: Car/motor vehicle 1.6 1.9 3.5 -1.9 -1.8 -0.9 -0.7 1.3
Illness, injury, bereavement, stress in last 2 years 1.2 1.5 2.7 1.1 1.3 -1.7 1.3 -0.3
Medication: Aspirin 1.3 1.7 5.4 -0.3 -0.5 0.5 1.6 2.3
Supplements: Vitamin C 1.4 1.6 3.0 1.6 1.2 -0.5 -0.8 -1.7
Knee pain experienced in last month 0.2 0.3 0.5 0.6 0.4 -0.7 -0.5 0.2
Hypertension (Self-reported) 1.6 4.4 15.2 -0.9 1.0 3.9 1.8 1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.2 2.3 -1.0 -0.4 0.8 1.5 1.5
Illnesses of father: Heart disease 0.1 0.2 0.3 0.5 0.4 0.5 -0.2 -0.6
Illnesses of siblings: Diabetes 3.3 4.1 5.2 -2.2 -2.2 -1.1 2.0 2.3
Smoking status: Previous 0.6 0.9 3.2 -0.7 -0.4 1.8 0.9 -0.1
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 2.8 -0.3 0.2 0.6 1.7 0.9
Whole body fat-free mass 0.4 2.4 4.3 -1.2 -1.0 0.9 2.1 2.1
Leg fat-free mass (right) 0.7 4.0 7.3 -2.1 -1.6 1.0 2.7 2.1
Arm fat percentage (left) 0.9 3.7 8.0 -2.8 -1.6 0.4 2.4 1.4
Average weekly red wine intake 0.3 0.4 0.8 0.6 0.9 0.9 -0.0 -0.2
Handedness (chirality/laterality): Left-handed 2.0 2.5 8.0 -0.7 -1.6 -2.8 -0.5 1.0
Mood swings 1.3 2.4 5.9 -2.2 -2.4 -0.2 -0.7 0.6
Loneliness, isolation 2.9 3.9 9.9 -3.1 -2.7 -0.2 -0.3 1.6
Long-standing illness, disability or infirmity 2.3 3.5 5.9 -2.4 -2.3 0.1 0.6 2.4
Ever had bowel cancer screening 0.2 0.3 1.1 -0.2 0.1 1.1 -0.2 0.1
Diabetes diagnosed by doctor 1.9 3.1 4.6 -1.9 -1.6 -1.0 2.1 1.9
Ever had stillbirth, spontaneous miscarriage or termination 0.2 0.2 0.8 -0.9 -0.1 -0.3 -0.4 -0.1
Friendships satisfaction 1.6 2.0 4.9 -2.2 -1.8 -0.4 -0.1 1.4
Qualifications: nursing, teaching 1.2 1.8 3.0 1.7 1.4 1.5 -0.4 -1.2
Commuting to job workplace: Walk 1.2 1.3 2.2 -0.6 -0.8 -1.4 1.5 1.2
Eye problems/disorders: Cataract 2.2 2.5 8.2 0.9 1.0 -0.6 -2.9 -1.5
Mouth/teeth dental problems: Mouth ulcers 0.7 1.1 2.8 1.2 0.5 1.7 0.4 -1.0
Medication for cholesterol 0.3 0.4 1.4 0.6 0.6 0.2 -0.1 -1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 3.0 -1.4 -1.7 -0.2 1.1 0.6
Back pain experienced in last month 1.0 1.5 3.1 -1.8 -1.3 -0.9 -0.8 1.2
Mineral and other dietary supplements 0.4 0.6 1.1 -0.8 -1.0 -0.1 -0.4 1.1
Breast cancer (self-reported) 0.1 0.1 0.3 0.5 0.1 -0.1 0.3 0.4
Asthma (self-reported) 1.1 2.3 5.2 -2.3 -1.7 0.7 -0.6 1.5
Osteoporosis (self-reported) 1.3 1.6 8.0 0.1 -0.0 -2.8 -0.2 -0.2
Osteoarthritis (self-reported) 1.1 1.5 3.9 -0.7 -0.5 -2.0 -1.6 -0.2
Medication: Aspirin 1.6 2.1 6.6 -0.7 -0.8 0.2 1.6 2.6
Medication: Gliclazide 2.1 2.4 3.8 -1.9 -1.5 -0.7 1.2 2.0
Illnesses of father: None of the above (group 1) 0.5 0.6 0.9 -0.7 -0.9 -1.0 -0.4 0.8
Smoking status: Current 0.1 0.1 0.4 0.1 -0.1 0.0 0.4 0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.3 0.7 1.5 1.1 0.1 -0.4 0.8 1.2
Whole body water mass 0.4 2.2 4.3 -1.1 -1.0 0.9 2.1 2.0
Leg predicted mass (right) 0.7 4.0 7.2 -2.1 -1.7 1.0 2.7 2.1
Arm fat mass (left) 0.9 3.6 7.0 -2.6 -1.7 0.6 2.3 1.6
Number of self-reported non-cancer illnesses 0.9 1.5 4.2 -1.5 -0.4 2.0 0.1 1.0
Average weekly champagne plus white wine intake 0.9 1.2 4.1 2.0 1.1 0.3 1.0 0.1
Miserableness 0.9 1.5 3.4 -0.8 -1.0 -1.9 -1.5 -0.4
Guilty feelings 0.3 0.4 0.9 0.9 0.3 -0.5 -0.8 -0.3
Wears glasses or contact lenses 1.2 1.4 2.6 1.6 1.3 1.5 0.7 0.3
Ever taken oral contraceptive pill 0.5 0.6 2.5 0.5 0.2 1.6 -0.1 -0.4
Hearing aid user 0.7 0.8 1.1 -0.9 -0.5 -1.0 -0.8 1.1
Mother’s age at death 4.6 5.7 11.7 3.4 2.6 0.6 -2.2 -2.2
Financial situation satisfaction 0.3 0.4 0.6 -0.7 -0.5 0.8 -0.8 0.0
Tinnitus: Yes, now most or all of the time 0.7 0.8 2.8 0.4 -0.9 -1.7 -0.5 0.1
Commuting to job workplace: Public transport 0.3 0.4 0.7 -0.6 -0.5 -0.6 0.9 0.4
Eye problems/disorders: Glaucoma 1.1 1.3 5.5 -0.4 -0.8 -2.4 -0.3 0.6
Medication: Blood pressure 0.5 1.0 2.6 -1.1 -0.7 0.1 0.7 1.6
Pain type(s) experienced in last month: Hip pain 0.9 1.2 2.4 -1.6 -1.0 -1.4 -0.7 0.4
Supplements: Fish oil (including cod liver oil) 0.3 0.4 0.6 0.8 0.7 0.6 0.0 -0.7
High cholesterol (Self-reported) 0.9 1.7 4.8 -0.2 -0.6 -0.3 2.2 1.7
Medication: Bendroflumethiazide 1.0 1.5 4.2 0.3 0.8 2.0 1.1 1.2
Medication: Paracetamol 0.9 1.4 2.3 -1.5 -1.4 -0.6 0.9 1.3
Medication: Lisinopril 0.7 0.9 2.6 0.5 0.8 1.6 0.7 0.8
Medication: Atorvastatin 0.9 1.1 2.7 -0.8 -0.8 -0.5 1.0 1.7
Illnesses of father: High blood pressure 1.5 1.9 4.9 0.7 0.9 2.2 -1.6 -0.8
Alcohol drinker status: Never 0.2 0.3 0.6 0.4 0.6 0.0 -0.8 -0.6
Ever smoked 0.3 0.6 2.5 0.5 0.2 1.6 0.2 -0.5
Basal metabolic rate 0.5 2.8 4.8 -1.6 -1.3 0.9 2.2 2.1
Leg fat percentage (left) 1.0 3.5 10.7 -3.3 -1.9 -0.4 1.2 1.1
Arm fat-free mass (left) 0.3 1.6 3.2 -1.0 -1.0 0.5 1.6 1.8
Number of operations (self-reported) 0.9 1.3 3.6 0.6 0.9 1.9 -1.2 -0.6
Average weekly beer plus cider intake 4.1 5.9 12.3 -2.1 -2.9 -3.5 0.7 2.0
Irritability 0.0 0.1 0.1 -0.2 -0.2 0.4 -0.3 -0.3
Risk taking 0.1 0.2 0.6 0.2 -0.4 0.0 -0.8 -0.3
Ever had prostate specific antigen (PSA) test 1.6 1.8 2.9 1.7 1.6 1.0 -1.2 -1.1
Fractured/broken bones in last 5 years 0.4 0.6 1.8 0.4 0.5 -0.6 -0.6 -1.3
Age started oral contraceptive pill 0.3 0.4 1.1 1.1 0.7 0.2 -0.4 0.2
Diastolic blood pressure, automated reading 1.3 4.0 12.3 1.0 2.1 3.5 1.3 -0.8
Ever depressed for a whole week 1.2 1.4 2.9 -1.1 -0.9 -0.8 1.7 1.2
Unable to work because of sickness or disability 1.3 1.7 3.3 -1.1 -1.3 -0.0 1.8 1.5
Commuting to job workplace: Cycle 0.2 0.3 0.6 0.4 0.4 0.8 0.3 -0.7
Myopia 0.2 0.3 0.7 0.8 -0.3 -0.2 -0.1 -0.8
Vascular/heart problems diagnosed by doctor 1.3 3.5 13.8 0.2 -1.4 -3.7 -1.0 -0.8
Cholesterol lowering medication 0.5 0.8 1.5 0.6 0.2 -0.8 1.1 1.2
Medication: Omeprazole (e.g. Zanprol) 1.2 1.5 3.3 1.8 1.5 1.1 -0.2 -0.7
Pain experienced in last month 0.3 0.6 1.1 0.9 1.0 0.5 0.7 -0.5
Supplements: Calcium 1.5 1.7 4.5 0.7 1.0 0.4 -1.4 -2.1
Basal cell carcinoma (self-reported) 2.4 2.8 5.2 1.5 0.9 1.0 -2.2 -2.3
Heart attack/myocardial infarction (self-reported) 2.0 2.6 6.3 2.5 1.8 1.7 0.3 0.2
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 2.8 0.5 0.4 0.0 -1.7 -0.7
Heart disease (siblings) 0.2 0.2 0.6 -0.2 -0.2 -0.1 0.8 0.5
Alcohol drinker status: Previous 1.4 1.6 3.0 -1.5 -0.8 1.1 1.7 0.9
Pack years of smoking 2.6 3.8 7.5 -2.7 -2.7 -1.1 0.7 1.7
Impedance of whole body 0.1 0.5 1.7 -0.0 0.2 -1.3 -0.4 -0.9
Leg fat mass (left) 1.3 5.3 12.2 -3.5 -2.2 0.2 2.3 1.9
Arm predicted mass (left) 0.4 1.8 3.5 -1.2 -1.1 0.5 1.6 1.9