Hub : Genes

ACTR3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.1310	0.0460	1.4e-04	0.010	NA	0.024	NA	0.041	5.6e-02	NA	6.6e-03	NA	5.0e-04
2	GTEx	Esophagus Mucosa	0.1320	0.0480	1.3e-03	0.008	NA	0.071	NA	0.052	9.2e-02	NA	1.7e-05	NA	2.1e-04
3	GTEx	Skin Not Sun Exposed Suprapubic	0.2390	0.0720	6.1e-06	0.124	NA	0.152	NA	0.154	2.8e-07	NA	1.1e-08	NA	8.7e-09
4	GTEx	Skin Sun Exposed Lower leg	0.1720	0.0520	6.7e-07	0.194	NA	0.100	NA	0.172	6.7e-16	NA	1.3e-08	NA	3.6e-14
5	GTEx	Thyroid	0.1390	0.0550	4.8e-04	0.007	NA	0.036	NA	0.019	9.0e-02	NA	8.6e-04	NA	1.3e-02
6	METSIM	Adipose	0.0363	0.0161	1.8e-03	0.014	0.004	0.010	0.008	0.012	2.8e-03	0.07800	1.1e-02	0.019	6.0e-03
7	TCGA	Bladder Urothelial Carcinoma	0.0460	0.0280	5.7e-03	0.021	0.014	0.002	NA	0.017	5.8e-03	0.02100	2.0e-01	NA	1.4e-02
8	TCGA	Breast Invasive Carcinoma	0.0243	0.0130	1.7e-04	0.029	0.015	0.013	NA	0.024	8.6e-07	0.00040	8.4e-04	NA	8.7e-06
9	TCGA	Liver Hepatocellular Carcinoma	0.1470	0.0700	3.3e-03	0.068	0.058	0.042	NA	0.064	3.9e-04	0.00100	4.6e-03	NA	6.1e-04
10	TCGA	Lung Adenocarcinoma	0.0458	0.0256	5.6e-03	0.019	0.012	0.008	NA	0.016	2.1e-03	0.01300	3.5e-02	NA	5.4e-03
11	TCGA	Pheochromocytoma and Paraganglioma	0.0830	0.0430	2.6e-03	0.124	0.058	0.073	NA	0.072	1.3e-05	0.00260	7.7e-04	NA	8.5e-04
12	TCGA	Prostate Adenocarcinoma	0.0616	0.0452	5.8e-03	0.001	0.024	0.030	NA	0.005	2.6e-01	0.00120	3.8e-04	NA	8.5e-02
13	TCGA	Thyroid Carcinoma	0.1020	0.0570	9.9e-05	0.045	0.031	0.023	NA	0.038	2.9e-05	0.00046	2.2e-03	NA	1.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Bipolar Disorder (2018)	0.7	1.1	5.9	0.1	-2.4	-0.5	-0.6	0.2	-1.4	-0.5	0.0	-0.7	-1.7	-0.7	-1.2	-0.8
Bipolar Disorder or Schizophrenia	0.1	0.3	1.6	0.3	-0.1	0.4	0.2	-0.8	-1.3	-0.8	0.0	-0.7	-0.1	-0.7	-0.1	-0.4
Depressed Affect (Nagel 2018)	0.5	1.1	4.3	-1.0	-0.0	-1.1	-1.1	-0.5	0.2	-0.6	-0.8	-1.2	-0.8	1.2	-2.1	-1.1
Depression (Nagel 2018)	1.3	1.9	4.9	0.1	1.3	-0.9	-1.3	-1.6	-0.5	-1.9	-2.1	-1.3	-1.0	-0.5	-1.4	-2.2
Intelligence (Savage-Jansen 2018)	1.0	3.1	6.3	0.1	1.6	2.2	2.0	0.4	0.0	2.4	1.9	1.6	2.3	1.6	1.5	2.5
Neuroticism (Nagel 2018)	0.4	1.0	2.1	0.5	0.5	-1.1	-1.3	-0.5	1.5	-0.7	-1.0	0.2	-1.4	-0.4	-1.4	-1.3
Schizophrenia (2018)	0.3	0.7	3.3	0.2	1.8	0.9	0.7	-1.2	-0.5	-0.7	0.0	-0.3	1.2	-0.4	0.8	0.1
Schizophrenia vs Biploar Disorder	0.4	0.6	3.7	0.4	1.9	-0.5	-0.5	0.5	1.0	0.1	0.0	0.8	0.2	-0.8	0.7	0.2
Worry (Nagel 2018)	0.6	1.3	4.8	1.7	1.8	-0.5	-0.6	0.4	2.2	0.0	-0.1	1.5	-0.9	-1.2	0.9	-0.3
Alzheimer’s Disease (in mother)	0.2	0.3	2.3	-0.3	0.4	0.2	0.1	-0.1	-0.8	0.6	0.1	0.2	0.1	1.5	0.3	0.1
Alzheimer’s Disease (in father)	0.5	0.5	2.2	-0.3	-0.8	-1.5	-0.9	0.5	-0.1	0.5	0.8	0.7	-0.6	-0.8	0.8	0.5
Alzheimer’s Disease (including proxy)	0.2	0.3	1.0	-0.3	-0.3	-1.0	-0.7	0.2	-0.5	0.6	0.4	0.5	-0.7	0.0	0.0	0.1
Crohns Disease (2017)	0.2	0.4	1.5	-0.4	0.0	1.0	1.2	-0.2	-1.0	0.2	0.3	-0.7	0.5	0.2	-0.6	0.4
Irritable Bowel Disease (IBD)	0.3	0.6	2.6	-0.3	-0.1	1.3	1.6	-0.3	-0.7	0.9	0.9	-0.2	0.6	0.4	0.2	0.9
Ulcerative Colitis (UC)	0.1	0.2	0.6	0.1	-0.6	0.5	0.8	-0.4	-0.3	0.8	0.5	0.1	0.2	0.1	0.3	0.6
Major Depression (MDD)	0.3	0.3	0.9	0.8	-0.9	-0.8	-1.0	0.4	0.3	-0.1	-0.0	0.4	-0.5	-0.6	0.1	-0.2
Reaction Time	0.2	0.4	1.9	-0.2	-0.8	-0.9	-1.4	0.6	0.3	0.2	0.1	-0.0	-0.9	0.0	0.1	-0.3
Verbal and Numeric Reasoning (VNR)	0.6	1.5	5.2	-0.6	0.6	1.8	1.8	-0.6	-0.6	1.3	0.8	0.4	2.3	1.1	0.3	1.4
Breast Cancer	0.9	2.2	6.7	0.4	-2.2	-2.6	-2.2	1.6	0.5	0.1	0.2	0.8	-2.4	-0.6	-1.7	-0.5
Ovarian Cancer	0.6	0.8	1.9	1.1	-0.9	-0.6	-0.9	0.0	0.3	-1.1	-1.2	-0.1	-0.9	-0.3	-1.4	-1.3
Prostate Cancer	1.1	1.5	4.1	-0.8	0.3	-0.8	-0.8	-1.0	-1.8	-1.4	-1.4	-2.0	-0.8	-0.1	-1.8	-1.5
Age at First Birth	0.7	1.0	2.2	1.3	-0.2	-1.2	-1.1	1.1	0.6	0.8	0.7	1.5	-1.5	-0.8	0.7	0.2
Bipolar Disorder (2011)	0.4	0.4	2.3	0.5	-1.5	-0.0	-0.3	-0.2	-0.4	-0.3	0.0	0.2	-0.9	-0.0	-0.8	-0.5
Body Mass Index (BMI) (2010)	0.2	0.3	1.6	1.3	0.3	0.0	0.4	0.5	0.5	0.1	-0.3	1.1	0.1	-0.2	0.5	-0.1
Coronary Artery Disease (CAD)	0.8	1.0	1.7	0.3	1.3	1.2	1.1	1.0	1.1	1.0	1.0	1.0	1.1	0.4	0.8	1.3
Crohns Disease (2012)	0.3	0.4	1.8	-1.0	-0.4	0.4	0.7	-0.2	-1.3	0.3	0.4	-0.7	0.6	0.5	-0.8	0.5
Mean Putamen Volume	1.0	1.1	3.0	1.2	0.1	1.5	1.3	-0.1	0.2	0.8	0.4	1.7	1.4	1.2	1.1	1.0
Fasting Glucose	0.7	0.8	3.5	0.4	0.1	-0.7	-0.4	0.5	1.9	1.0	0.9	1.2	-0.1	-0.3	1.4	0.8
HbA1C	1.1	1.2	4.1	0.9	0.1	-1.9	-2.0	0.8	0.9	-0.7	-0.5	0.3	-1.5	-1.2	-0.6	-0.8
HDL Cholesterol	0.2	0.3	1.5	-0.5	-0.7	-0.0	0.1	-1.2	0.1	0.2	0.6	-0.9	0.3	-0.4	-0.3	0.5
LDL Cholesterol	0.7	1.1	3.8	-1.1	1.9	0.8	1.1	-0.1	-0.6	0.9	1.0	-0.2	1.4	0.9	1.1	1.3
Lupus	1.9	2.9	8.9	1.6	-0.2	-1.0	-1.0	-1.2	-0.0	-2.6	-3.0	-0.6	-1.3	-1.0	-1.9	-2.9
Neuroticism (2016)	1.2	1.7	4.2	1.3	0.9	-1.1	-1.4	0.6	-0.0	-1.2	-1.5	0.4	-2.0	-1.3	-1.8	-1.8
Primary Biliary Cirrhosis	3.3	4.7	10.7	-1.2	0.4	2.9	3.0	0.3	-0.3	2.4	2.2	0.3	3.3	2.8	2.0	2.9
Rheumatoid Arthritis	0.9	1.2	4.2	1.2	-0.9	-0.5	-0.8	1.7	1.1	1.2	0.9	2.1	-0.6	0.8	0.5	0.7
Schizophrenia (2014)	0.4	0.9	2.7	-0.1	1.6	1.2	1.2	-1.2	-0.4	-0.3	0.0	-0.5	1.6	-0.5	1.1	0.7
Triglycerides	0.2	0.3	1.2	0.3	0.7	-0.2	-0.0	1.1	0.1	0.3	0.0	0.8	-0.2	1.1	0.3	0.0
Type 2 Diabetes (T2D) (2012)	1.4	1.6	5.0	0.3	1.6	1.6	2.2	-0.4	0.7	0.6	0.5	0.8	1.9	1.2	1.5	1.2
Ulcerative Colitis	1.3	1.9	6.0	-0.7	-0.9	0.8	0.8	0.9	0.5	2.5	2.1	1.0	0.6	2.0	1.1	2.1
Blood Eosinophil Count	0.1	1.0	3.0	-1.4	-0.5	0.7	0.9	-1.7	-1.5	-0.1	-0.3	-1.4	1.2	0.4	-0.3	0.1
Blood Platelet Count	0.2	1.8	4.3	-0.9	0.8	2.1	1.8	-2.0	-1.7	0.4	0.3	-1.4	1.6	1.2	-0.6	0.7
Blood Red Count	0.3	3.4	13.2	1.6	-0.3	-1.0	-0.9	2.6	1.9	1.9	2.2	3.6	-0.7	-1.3	1.3	1.9
Blood White Count	0.2	1.5	3.9	1.9	1.2	1.2	0.9	-2.0	0.5	-1.1	-1.8	1.0	1.0	0.3	0.5	-1.0
Heel T-Score	0.2	1.5	4.5	0.8	0.6	-1.1	-0.9	2.1	0.2	0.7	1.3	1.4	-1.2	-1.9	1.2	0.7
BMI	0.1	0.8	3.3	-1.0	-0.3	-1.8	-1.7	0.4	-0.2	-0.1	0.5	-0.6	-1.3	-0.6	-0.8	0.0
Height	1.1	21.7	47.9	-2.1	2.7	4.6	4.3	1.5	2.3	6.5	6.3	2.8	4.5	4.6	6.8	6.9
Waist Hip Ratio (WHR)	6.5	29.2	63.8	-1.8	3.0	4.9	5.2	2.4	4.1	8.0	7.3	4.3	4.8	5.3	6.6	8.0
Systolic Blood Pressure	1.9	9.4	18.7	1.4	2.9	4.2	3.2	1.6	2.6	2.9	2.8	2.8	3.4	2.6	4.3	3.6
Smoking Status	0.8	2.0	5.7	-2.4	-1.7	1.2	1.0	-1.6	-1.2	1.1	0.6	-1.4	1.5	2.1	-0.5	0.9
Allergy or Eczema	0.5	1.4	4.0	-0.7	0.2	0.0	0.2	2.0	1.7	2.0	1.7	1.1	-0.3	0.9	0.5	1.4
Cardiovascular Disease	1.5	5.1	12.0	-0.1	2.2	2.3	2.0	1.0	2.4	2.5	2.7	1.3	1.9	2.2	3.5	3.0
Hypothyroidism (self reported)	0.4	0.9	2.3	0.5	-0.3	-0.3	-0.2	1.3	1.0	1.2	1.3	1.1	-0.1	0.2	1.5	1.2
Respiratory disease	0.1	0.2	0.7	-0.2	0.5	0.3	0.6	-0.8	-0.6	0.3	0.1	-0.1	0.6	-0.0	0.4	0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.4	-0.8	-0.8	0.4	0.9	0.1	-1.2	0.8	0.9	-0.6	0.8	1.0	0.7	1.0
Lung FEV1/FVC ratio	0.1	0.6	2.3	-0.3	0.3	-1.5	-1.3	-0.0	-0.0	0.6	0.8	0.7	-1.0	-1.0	0.8	0.4
Lung FVC	1.2	6.3	16.8	1.0	-2.1	-3.1	-3.4	0.4	-0.6	-2.6	-1.6	-0.9	-4.0	-4.1	-2.1	-2.8
Neuroticism	0.2	0.5	1.1	0.2	0.6	-0.7	-0.7	-0.5	0.6	-0.8	-0.9	-0.1	-0.7	-0.5	-1.1	-1.0
Chronotype (morning person)	0.6	1.3	3.0	-0.2	-1.1	0.2	0.5	1.3	1.2	1.6	1.7	1.1	0.1	-0.3	1.5	1.6
Hair Pigment	0.0	0.9	3.9	0.5	-0.0	-0.4	-0.4	-1.4	-0.3	-1.2	-1.0	-0.4	-0.8	-2.0	-1.0	-1.2
Tanning	0.1	1.6	3.4	1.8	-1.2	0.3	-0.2	-1.8	0.7	-1.4	-1.8	0.2	-0.3	-1.1	-1.8	-1.6
Hand grip strength (left)	0.3	0.8	3.3	0.5	-1.5	0.4	0.0	-1.8	0.2	-0.9	-0.6	-0.4	-0.1	-1.2	-0.8	-0.6
Number of treatments/medications taken	0.2	0.4	1.0	-0.8	-1.0	-0.6	-0.6	0.8	0.9	0.4	0.5	-0.7	-0.2	1.0	0.2	0.3
Average weekly spirits intake	0.5	0.7	1.7	0.6	0.4	-0.5	-0.8	-1.3	-0.2	-1.2	-0.9	-0.4	-0.7	-1.1	-0.9	-0.9
Sensitivity / hurt feelings	0.5	0.8	2.5	0.2	-0.4	-0.8	-1.4	-1.2	0.6	-0.5	-0.4	0.4	-1.2	-1.6	-0.6	-0.7
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.1	-0.9	0.9	-0.1	-0.3	-1.5	0.2	-1.0	-1.1	-1.4	0.1	0.3	-1.3	-1.1
Hearing difficulty/problems: Yes	1.0	1.6	4.4	0.5	1.8	1.1	1.0	-1.0	-2.1	-1.5	-1.7	-1.1	0.7	0.7	-0.7	-1.3
Relative age of first facial hair	1.0	2.1	7.6	-2.6	-0.1	1.4	1.5	-1.7	-1.5	-0.2	0.0	-2.7	1.2	1.3	-0.4	0.2
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	6.6	-1.4	2.2	1.7	1.7	-0.8	-0.0	0.9	0.6	-0.2	2.5	2.6	2.2	1.3
Ever used hormone-replacement therapy (HRT)	1.9	2.5	6.7	0.9	0.3	-1.8	-2.1	0.0	-1.6	-2.0	-2.3	-0.1	-2.0	-0.4	-0.7	-2.6
Ever had hysterectomy (womb removed)	0.2	0.2	0.8	-0.1	0.7	0.3	0.0	-0.0	0.6	0.1	0.2	0.3	0.5	-0.3	0.9	0.4
Systolic blood pressure, automated reading	1.8	5.2	13.0	2.3	3.2	1.6	0.8	2.8	2.4	1.8	1.6	3.3	1.0	1.1	3.6	1.9
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	4.3	1.1	-0.5	-0.4	-0.5	0.5	2.1	0.8	0.8	1.7	-0.3	-0.3	1.0	0.8
Angina	0.7	0.9	2.8	-1.7	-1.4	-0.6	-0.5	0.1	-1.5	0.4	-0.1	-1.6	-0.3	1.1	-0.8	-0.3
Medication for hormone replacement therapy	2.3	2.5	6.2	1.2	-0.8	-2.3	-2.5	0.7	-0.2	-1.6	-1.6	0.4	-2.4	-1.8	-0.9	-2.0
Vitamin and mineral supplements	0.9	1.3	6.2	1.7	1.5	-0.1	-0.1	0.8	0.8	0.4	0.1	1.9	0.2	-0.3	2.5	0.3
Supplements: Zinc	1.2	1.3	5.2	0.6	1.6	1.7	1.2	-2.3	0.2	-0.8	-1.2	0.4	1.4	0.1	-0.3	-0.6
Medication: Co-codamol	0.1	0.1	0.3	0.2	0.2	-0.2	-0.3	0.0	-0.6	-0.3	-0.4	0.3	0.4	-0.0	0.5	-0.2
Medication: Metformin	0.3	0.5	2.2	0.1	-1.5	-0.3	-0.3	0.8	-0.6	0.7	0.8	0.3	-0.3	0.6	0.7	0.7
Diabetes (father)	0.5	0.6	3.1	1.8	0.3	-0.3	-0.5	-0.5	0.0	-0.5	-0.7	1.2	-0.3	-0.9	0.4	-0.6
Diabetes (mother)	0.7	0.9	1.8	1.3	-0.4	0.4	0.3	0.9	1.3	1.2	1.3	1.2	-0.1	0.2	0.9	1.2
Severe depression (siblings)	1.6	1.7	4.6	-0.8	-1.2	-0.9	-0.6	-0.8	-1.3	-1.7	-1.5	-2.0	-0.7	-0.2	-2.1	-1.6
Pack years adult smoking proportion	0.9	1.4	5.6	-0.9	-0.0	0.7	0.9	-2.4	-1.7	-1.0	-1.0	-2.0	0.9	0.6	-0.4	-0.7
Impedance of leg (right)	0.6	2.8	5.9	1.5	1.6	2.4	2.4	-0.5	1.0	1.1	0.7	2.3	1.9	0.8	2.4	1.3
Leg fat-free mass (left)	0.5	2.5	6.6	-2.6	1.2	1.0	0.8	0.4	0.1	2.0	2.1	-1.0	1.4	2.2	1.0	2.2
Trunk fat percentage	0.7	2.9	7.3	-0.8	0.4	-0.4	-0.4	2.4	1.0	2.6	2.7	1.6	0.2	1.6	1.7	2.6
Hand grip strength (right)	0.2	0.7	3.6	-0.3	-1.0	0.6	0.5	-1.9	0.2	-0.3	0.1	-0.8	-0.2	-1.3	-0.9	-0.1
Townsend deprivation index at recruitment	1.9	2.7	5.3	-2.1	1.3	2.1	2.1	-0.8	-1.4	1.4	1.3	-0.7	2.3	1.9	0.9	1.8
Current tobacco smoking	1.7	2.9	7.5	-2.0	0.3	2.3	2.0	-2.7	-1.3	0.1	-0.2	-2.1	2.5	1.8	-0.1	0.5
Average weekly fortified wine intake	0.4	0.4	1.3	-1.1	0.3	-0.2	-0.5	-0.2	0.2	1.0	1.1	0.5	0.0	-0.1	0.9	0.8
Maternal smoking around birth	0.8	1.2	3.2	0.2	1.6	0.8	0.7	0.2	0.6	1.1	1.4	1.4	0.7	-0.5	1.8	1.5
Fed-up feelings	1.0	1.8	6.4	-2.5	0.3	0.3	0.7	-0.8	0.1	1.6	1.4	-1.0	1.2	2.5	0.0	1.5
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.4	-0.2	1.2	-0.0	-0.4	-1.1	-0.6	-0.7	-0.9	-0.6	-0.1	0.3	-0.8	-0.8
Relative age voice broke	0.6	1.0	1.8	-1.1	1.0	1.2	1.1	-1.0	-0.9	-0.9	-1.0	-1.3	1.3	0.5	-0.4	-0.5
Taking other prescription medications	0.4	0.6	1.8	-0.3	-1.3	-1.3	-1.3	0.8	0.7	0.2	-0.0	0.0	-1.0	-0.4	-0.1	-0.3
Age when periods started (menarche)	0.8	1.9	4.8	0.1	-1.0	-1.1	-1.1	-0.8	-0.5	-1.9	-1.8	-1.6	-1.2	-0.8	-2.2	-2.0
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.2	1.3	-0.2	0.8	0.4	0.7	1.4	0.7	0.1	1.8	0.4	0.7	0.2	0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.2	0.4	0.9	0.6	0.1	-0.5	-0.8	-0.7	-0.6	-0.6	-0.8	0.5	-0.4	-1.0	-0.2	-0.7
Tinnitus: Yes, but not now, but have in the past	0.4	0.4	1.7	0.7	-0.8	-0.4	-0.4	0.7	0.5	-0.5	-0.4	0.2	-0.7	-0.9	-1.3	-0.5
Qualifications: CSEs or equivalent	0.8	1.1	2.8	-0.7	0.3	-0.7	-0.2	-0.8	-1.7	-1.5	-1.1	-1.4	-0.1	-1.3	-1.3	-1.1
Serious illness, injury or assault to yourself	1.7	2.1	4.6	-1.1	0.7	2.0	2.1	-0.4	1.2	1.7	1.9	-0.4	1.4	1.4	0.9	2.0
High blood pressure	0.6	1.8	4.2	1.1	1.2	1.0	0.8	1.6	2.1	1.2	1.6	1.2	0.0	0.7	1.9	1.5
Hayfever, allergic rhinitis or eczema	0.7	1.6	6.2	-0.3	0.1	0.0	0.3	2.5	1.4	2.1	1.8	1.4	-0.1	0.7	0.4	1.6
Multivitamins +/- minerals	0.8	1.0	2.2	-1.3	-1.5	1.3	1.0	-0.8	-0.3	0.6	1.0	-0.7	1.0	1.1	-0.8	1.1
Stomach or abdominal pain in last month	0.4	0.5	1.3	0.3	0.4	0.9	0.9	0.1	0.1	0.5	0.3	1.1	1.1	0.4	1.0	0.6
Supplements: Glucosamine	1.5	2.0	4.9	-1.6	-1.8	-2.2	-2.2	1.1	-0.9	0.4	0.7	-0.6	-2.1	-0.6	-1.5	-0.1
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.3	-0.0	0.2	-0.3	-0.5	1.2	0.9	0.8	1.3	0.9	-0.4	-0.1	1.5	1.0
Medication: Atenolol	0.4	0.5	2.9	0.5	-0.1	0.9	0.6	-0.3	-1.2	0.1	-0.3	0.3	0.8	1.7	0.6	0.1
Medication: Levothyroxine sodium	0.5	0.8	2.6	1.4	0.3	-0.4	-0.3	1.4	1.0	0.4	0.3	1.6	-0.3	-0.5	1.5	0.3
Sitting height	0.8	5.3	10.5	-2.1	2.1	3.0	2.8	-1.0	-0.1	2.2	2.2	-0.4	3.0	3.2	2.6	2.7
Chronic bronchitis/emphysema (father)	1.3	1.5	3.7	-0.7	0.2	1.2	1.4	1.1	1.5	1.9	1.7	0.0	0.8	1.5	-0.4	1.7
High blood pressure (mother)	0.3	0.5	1.2	-0.6	-1.0	0.3	-0.1	1.1	0.6	0.5	1.0	-0.4	-0.2	0.9	0.7	0.8
Body mass index (BMI)	0.3	1.2	4.0	-0.9	-0.4	-2.0	-2.0	1.5	0.3	0.9	1.1	0.2	-1.1	0.3	-0.1	0.7
Impedance of leg (left)	0.7	3.2	6.8	1.4	1.7	2.3	2.5	-0.3	1.4	1.4	1.1	2.5	1.9	0.8	2.6	1.6
Leg predicted mass (left)	0.5	2.4	6.8	-2.6	1.2	0.9	0.8	0.4	0.1	2.0	2.1	-1.1	1.3	2.1	1.0	2.1
Trunk fat mass	0.8	3.3	9.3	-1.6	0.5	-0.2	-0.2	2.2	0.9	3.0	3.0	1.0	0.4	2.0	1.8	2.9
Waist circumference	1.7	6.2	16.5	-1.0	1.1	0.2	0.2	2.8	2.0	4.1	4.0	2.3	0.6	2.3	2.9	3.8
Number of incorrect matches in round	1.1	1.8	4.9	1.4	0.8	0.0	-0.4	-0.7	-0.8	-1.8	-2.1	-0.7	-1.1	-1.2	-1.9	-2.2
Past tobacco smoking	0.4	0.7	3.1	1.8	1.5	0.9	1.1	0.8	0.5	-0.5	-0.4	0.5	0.3	-0.1	0.3	-0.1
Alcohol usually taken with meals	1.1	1.8	5.6	0.5	-1.8	-1.8	-2.3	1.4	0.9	-0.1	-0.2	0.6	-2.4	-0.6	-1.0	-0.9
Nervous feelings	0.6	1.1	3.4	0.6	1.9	1.2	0.9	-0.2	1.4	0.8	0.9	0.9	0.7	-0.3	1.4	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.6	0.9	5.1	-0.0	1.2	0.7	0.5	-2.3	0.6	-0.6	-1.1	0.1	1.4	0.1	0.1	-0.5
Hearing difficulty/problems with background noise	1.8	2.9	5.2	1.8	-0.3	-1.8	-1.8	1.1	0.1	-1.9	-1.9	0.2	-2.2	-1.9	-2.2	-2.3
Hair/balding pattern: Pattern 2	2.7	3.4	11.0	-0.7	2.7	2.6	2.9	-1.6	0.6	0.4	0.4	-0.4	3.3	1.2	1.8	1.3
Had menopause	1.2	1.5	5.7	0.6	0.2	-1.7	-2.0	2.4	-0.6	0.5	0.2	1.3	-1.8	-0.6	0.9	-0.2
Had other major operations	0.5	0.6	1.5	0.7	-1.2	-0.0	-0.1	-0.4	0.3	-0.8	-1.2	0.2	-0.5	0.0	-1.2	-1.1
Forced vital capacity (FVC)	0.3	1.0	3.3	-1.0	0.4	0.8	0.6	-0.0	1.4	1.1	1.8	0.1	0.4	-0.5	1.3	1.6
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	4.2	0.4	0.2	-1.4	-1.6	-0.2	-0.8	-0.8	-0.4	-0.2	-1.4	-2.0	-0.2	-0.7
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	1.4	0.4	1.2	0.1	0.3	0.3	0.7	-0.1	0.2	0.6	0.4	-0.3	0.7	0.2
Qualifications: None of the above	1.1	2.4	8.0	0.6	0.5	-1.8	-1.4	-0.5	-0.9	-2.3	-1.8	-1.1	-1.5	-2.8	-0.8	-2.0
Financial difficulties in last 2 years	1.4	1.9	5.5	0.8	1.8	1.4	1.2	-2.3	0.1	-1.6	-2.0	-1.0	0.7	0.1	-1.3	-1.5
Mouth/teeth dental problems	3.1	4.8	11.5	2.6	3.2	1.3	1.2	2.5	1.7	1.8	1.8	3.2	0.8	-0.1	3.4	2.0
Heart attack	1.5	2.0	4.2	-0.3	-0.5	1.5	1.5	-0.4	0.1	2.0	1.8	0.8	1.5	1.4	2.0	2.1
Allergy	0.5	1.2	3.7	0.6	0.5	-0.6	-0.8	-1.1	-1.6	-1.9	-1.6	-1.0	-0.5	-0.6	0.0	-1.6
Pain all over the body in last month	1.2	1.2	2.4	-0.5	1.5	1.1	0.8	-0.4	0.8	1.5	1.2	0.5	1.3	0.9	1.5	1.5
Diabetes (self-reported)	0.6	1.0	2.3	-0.7	-0.5	0.8	0.9	0.6	-1.0	1.5	1.2	0.1	0.8	1.4	1.0	1.4
Hayfever/allergic rhinitis (self-reported)	2.0	2.7	5.7	-0.2	-0.8	1.1	0.9	2.0	1.6	2.4	2.1	1.4	0.5	2.2	2.0	2.0
Medication: Ramipril	1.4	1.9	5.9	-1.5	-0.9	1.2	0.9	0.5	-0.7	2.2	1.9	-0.3	0.3	2.4	0.3	1.8
Medication: Simvastatin	0.3	0.5	1.4	-1.2	-0.4	0.1	0.1	0.3	0.5	1.1	0.9	-0.9	0.3	1.0	0.1	0.8
Fluid intelligence score	0.8	1.7	5.9	-0.3	1.1	2.4	2.4	-1.2	-0.2	0.9	0.7	0.1	2.1	1.1	-0.1	1.2
Illnesses of siblings	1.6	2.2	7.6	0.1	-0.1	-0.5	-0.6	-2.0	-1.5	-1.7	-1.6	-1.1	-1.0	-1.7	-2.8	-1.8
Neuroticism score	0.1	0.2	1.2	-0.0	0.8	0.1	-0.1	-1.1	0.6	-0.2	-0.4	-0.0	-0.1	-0.1	-0.7	-0.4
Weight	0.6	2.8	7.5	-2.1	1.1	0.2	0.1	1.2	0.5	2.6	2.7	0.1	0.9	2.0	1.8	2.7
Impedance of arm (right)	1.0	4.7	9.2	1.3	1.4	2.4	2.5	1.4	1.8	2.2	1.9	2.9	2.2	2.0	3.0	2.5
Arm fat percentage (right)	0.6	2.5	6.5	-1.0	-0.4	-1.3	-1.1	2.5	0.7	2.3	2.5	1.2	-0.3	1.2	1.0	2.2
Trunk fat-free mass	0.4	2.0	5.8	-2.4	1.5	1.1	0.8	-0.3	-0.0	1.7	1.8	-1.3	1.2	1.6	1.1	1.8
Hip circumference	0.2	0.7	2.2	-0.8	-0.3	-1.4	-1.5	1.2	0.1	0.7	0.9	-0.0	-0.8	0.7	0.1	0.6
Time employed in main current job	0.4	0.5	2.8	0.9	1.7	0.5	0.5	-0.0	0.0	0.0	0.1	0.9	0.4	-0.0	1.2	0.3
Alcohol intake versus 10 years previously	0.5	0.8	2.3	-0.9	-0.8	0.9	1.2	-0.7	0.0	0.8	0.6	-0.4	1.3	1.5	0.2	0.9
Father’s age at death	0.5	0.7	2.9	-0.7	0.7	-1.7	-1.7	0.9	-0.2	-0.2	-0.0	-0.2	-1.0	-0.3	0.3	-0.3
Worrier / anxious feelings	0.6	1.1	3.2	-0.1	1.1	-1.5	-1.7	-0.6	0.9	-0.4	-0.2	-0.2	-1.5	-1.8	-0.5	-0.7
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	4.3	-1.8	-1.0	-0.2	-0.1	-0.7	-2.1	0.4	0.4	-1.1	0.4	1.4	-0.9	0.5
Falls in the last year	1.2	1.7	4.3	-0.2	-0.7	-0.3	-0.5	-1.7	0.7	-1.9	-2.1	-1.5	-0.4	-0.6	-1.6	-2.0
Hair/balding pattern: Pattern 3	0.6	0.9	2.8	0.9	0.5	0.9	0.5	0.8	1.7	0.8	0.7	1.1	0.4	1.0	1.4	0.8
Number of live births	0.6	0.9	2.7	1.6	1.5	-0.1	-0.2	-0.5	0.7	-1.2	-1.3	0.5	-0.3	-0.9	-0.4	-1.2
Forced expiratory volume in 1-second (FEV1)	0.3	1.1	4.7	-0.9	0.2	0.2	0.2	0.3	1.0	1.3	2.2	0.5	0.3	-0.6	1.6	1.8
Pulse rate	0.7	1.1	3.4	-0.2	-1.4	0.9	0.7	-0.2	1.9	1.6	1.3	0.7	0.2	1.3	0.0	1.2
Happiness	1.3	1.6	3.3	-1.0	0.5	-1.2	-1.1	-1.5	-0.2	-1.8	-1.7	-1.7	-0.1	-1.2	-1.4	-1.6
Noisy workplace	2.2	2.7	5.3	-0.3	-1.5	-2.3	-1.8	0.0	-1.4	-1.7	-1.2	-2.0	-2.2	-1.9	-1.6	-1.9
Qualifications: A levels/AS levels or equivalent	0.7	1.6	3.4	0.1	0.1	1.5	1.1	0.7	1.1	1.4	1.5	1.3	1.5	1.4	1.5	1.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.4	0.6	-0.6	-0.0	-0.4	-0.6	-1.2	-1.3	-1.6	-0.4	-0.4	0.4	-0.8	-1.5
Mouth/teeth dental problems: Dentures	1.4	2.3	5.3	-0.9	-0.3	-0.4	-0.3	-2.1	-1.2	-2.1	-2.3	-1.9	-0.1	-1.0	-1.9	-2.2
Asthma	0.1	0.1	0.6	-0.2	-0.2	-0.4	-0.1	-0.4	0.7	0.3	-0.2	0.2	-0.2	-0.2	-0.4	-0.2
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.1	5.3	-1.1	-1.1	-1.0	-0.6	0.4	-0.5	-0.8	-0.5	-1.8	-0.6	-0.4	-2.3	-0.7
Medication: Cholesterol lowering	0.6	1.0	2.2	-1.5	-1.1	-0.1	0.0	0.6	0.0	1.3	1.4	-0.9	0.7	1.4	0.8	1.3
Depression (self-reported)	0.5	0.6	4.2	1.1	0.2	0.0	-0.3	-0.8	2.0	-0.5	-0.6	0.7	-0.1	0.1	0.3	-0.5
Medication: Lansoprazole	0.1	0.2	0.9	0.1	0.2	0.0	-0.3	-0.5	-0.6	-0.0	-0.3	-0.1	-0.0	0.6	-0.9	-0.2
Prospective memory result	0.9	1.2	2.9	0.9	-0.4	-1.7	-1.7	0.3	0.3	-1.2	-1.0	0.1	-1.6	-1.2	-0.2	-1.4
Lung cancer (father)	0.6	0.7	1.8	0.3	0.1	1.1	1.3	0.8	0.7	1.3	0.8	0.8	0.7	0.4	0.1	0.9
Illnesses of mother	0.9	1.2	4.0	-1.9	-1.0	-0.3	0.4	-0.5	-1.3	-0.1	-0.1	-2.0	0.1	0.3	-2.0	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	3.5	-0.6	-0.3	-0.1	-0.1	0.5	1.3	1.1	1.9	0.7	0.0	-1.0	1.4	1.5
Pulse wave Arterial Stiffness index	0.8	0.9	3.2	-0.8	-1.8	-0.5	-0.8	0.5	-0.9	1.4	1.4	-0.1	-0.9	0.1	-0.9	0.9
Impedance of arm (left)	1.0	4.6	7.9	1.1	1.6	2.8	2.8	0.9	1.3	2.0	1.8	2.6	2.4	2.0	2.8	2.4
Arm fat mass (right)	0.5	2.1	5.9	-1.5	0.2	-1.0	-0.9	1.9	0.7	2.2	2.4	0.7	-0.1	1.4	1.2	2.2
Trunk predicted mass	0.4	2.1	6.3	-2.5	1.4	1.1	0.8	-0.3	0.0	1.8	1.9	-1.3	1.2	1.7	1.1	1.9
Standing height	1.2	11.9	19.7	-2.6	3.3	4.4	4.3	-0.5	0.6	3.9	3.7	0.1	4.2	3.7	4.2	4.4
Length of working week for main job	1.0	1.1	3.8	-0.8	0.4	1.4	1.3	-1.4	0.6	0.6	0.7	-0.2	2.0	0.7	0.7	1.2
Exposure to tobacco smoke at home	1.5	1.7	5.5	-1.9	0.6	1.2	1.1	-0.7	0.8	1.4	0.9	-0.5	1.7	2.3	1.1	1.2
Breastfed as a baby	1.1	1.4	4.8	1.7	0.2	0.4	0.0	-0.8	-0.1	-2.1	-2.2	0.0	0.0	-1.2	-0.2	-1.9
Tense / ‘highly strung’	0.7	1.1	5.0	1.9	1.0	0.7	0.3	0.4	1.8	0.4	-0.1	2.2	-0.2	-0.5	0.5	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	1.5	0.1	-1.1	-0.6	-0.7	-0.7	0.1	-0.7	-0.6	-0.8	-0.7	0.3	-1.2	-0.9
Hair/balding pattern: Pattern 4	0.1	0.2	0.8	0.9	0.7	0.5	0.6	0.5	-0.5	-0.1	-0.3	0.3	0.6	-0.1	-0.1	-0.0
Birth weight of first child	1.5	2.7	4.7	0.1	1.5	2.1	1.8	1.3	0.6	1.8	1.5	1.8	1.6	2.2	1.9	1.9
Peak expiratory flow (PEF)	0.3	0.6	1.5	-1.2	-0.5	-1.1	-0.9	-0.3	-0.5	0.5	1.2	-0.0	-0.4	-0.9	0.7	0.8
Pulse wave reflection index	1.3	1.7	6.3	-0.9	-1.8	-0.7	-0.9	-0.8	-1.8	-0.5	-0.1	-2.0	-1.2	-0.5	-2.5	-0.5
Ever highly irritable/argumentative for 2 days	0.8	1.0	3.6	-1.3	-0.2	1.0	0.8	-1.9	1.0	0.3	-0.1	-0.7	1.4	1.4	-0.1	0.2
Loud music exposure frequency	0.7	0.7	2.7	-0.9	-0.2	0.5	0.7	-1.6	-1.5	-0.7	-0.2	-1.5	0.7	0.1	-0.3	-0.1
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	1.9	0.5	-1.0	-0.1	-0.3	1.2	1.2	0.6	0.6	1.4	-0.0	0.2	-0.3	0.5
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	2.3	-0.4	-1.1	0.3	0.3	-0.9	0.4	0.1	-0.0	-0.3	0.3	1.5	-0.1	0.1
Blood clot in the leg (DVT)	0.5	0.6	2.8	-0.6	0.4	0.5	0.4	-1.5	-1.7	-0.8	-0.6	-0.6	0.9	-0.5	0.3	-0.3
Medication: Paracetamol	0.2	0.3	1.7	-0.2	-0.1	0.1	0.1	-0.4	-0.2	-0.3	-0.6	-0.7	0.3	0.4	-1.3	-0.4
Headache pain in last month	0.1	0.2	0.6	-0.6	0.2	-0.2	-0.2	-0.1	-0.7	-0.3	0.1	-0.1	0.8	0.7	-0.1	0.4
Medication for cholesterol, blood pressure or diabetes	0.4	0.7	1.6	0.9	0.3	-0.4	-0.1	-0.3	-0.5	-1.1	-1.2	0.6	-0.5	-1.3	-1.0	-1.2
Glaucoma (self-reported)	0.1	0.2	0.5	0.0	-0.5	-0.6	-0.1	0.7	0.4	-0.1	0.1	-0.3	-0.4	-0.3	0.6	-0.0
Gout (self-reported)	0.4	0.6	1.3	1.1	-0.0	-0.6	-0.9	0.5	1.1	-0.8	-0.8	0.5	-0.7	-0.5	-0.3	-0.9
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	0.9	-0.5	-0.3	-0.4	1.0	0.7	0.6	0.5	1.1	-0.1	0.2	0.8	0.5
Medication: Amlodipine	0.4	0.6	2.2	1.2	1.5	0.9	0.8	-0.6	0.1	-0.9	-0.7	0.0	0.7	0.0	0.5	-0.3
Medication: Ventolin 100micrograms inhaler	0.6	0.8	2.3	0.4	-0.2	-0.4	-0.4	-1.3	-0.4	-1.3	-1.5	-0.8	-0.0	-0.5	-1.4	-1.3
Birth weight	0.6	1.2	4.3	0.0	0.0	0.9	0.8	1.2	0.1	2.1	1.7	1.4	0.3	1.2	0.3	1.6
Chronic bronchitis/emphysema (mother)	0.4	0.4	1.3	0.9	0.5	0.2	0.0	-0.9	0.1	-0.7	-1.2	0.6	0.0	-0.1	0.4	-1.0
High blood pressure (siblings)	0.9	1.2	5.6	0.0	-0.3	-0.1	0.0	2.1	0.4	1.1	1.3	0.8	0.5	0.4	2.4	1.4
Forced vital capacity (FVC), Best measure	0.2	0.6	2.0	-0.8	-0.3	0.3	0.3	-0.0	1.2	0.6	1.4	-0.0	0.2	-0.9	1.0	1.1
Body fat percentage	0.7	2.8	7.4	-1.0	0.1	-0.9	-0.9	2.5	0.9	2.6	2.7	1.4	-0.1	1.4	1.5	2.5
Leg fat percentage (right)	0.4	1.6	3.9	-0.8	0.1	-1.5	-1.4	2.0	0.6	1.8	1.9	0.9	-0.7	0.8	0.8	1.5
Arm fat-free mass (right)	0.3	1.3	5.2	-2.3	1.1	0.4	0.2	-0.1	0.0	1.4	1.5	-1.2	0.7	1.4	0.7	1.4
Exposure to tobacco smoke outside home	0.5	0.7	3.5	-0.1	1.9	0.3	0.4	-1.2	0.0	-0.8	-0.9	-0.2	0.9	-0.2	0.7	-0.5
Comparative body size at age 10	2.0	5.6	15.5	-0.2	-3.2	-3.9	-3.7	1.1	-0.1	-1.3	-0.7	-0.8	-3.5	-2.4	-2.9	-1.7
Number of full brothers	1.3	1.7	6.4	-0.1	0.6	2.5	2.4	-1.7	-0.9	-0.1	-0.2	-0.7	1.9	1.0	0.9	0.3
Worry too long after embarrassment	0.2	0.4	1.8	0.6	1.4	0.8	0.5	-0.4	-0.2	-0.3	-0.0	0.4	0.1	-0.9	-0.6	-0.0
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.7	0.0	0.8	0.2	0.5	-1.2	1.3	-0.4	-0.3	-0.3	0.0	0.4	-0.0	-0.3
Wheeze or whistling in the chest in last year	0.6	1.1	3.6	-0.5	-0.4	1.2	1.7	-1.9	-0.7	-0.7	-0.8	-1.5	1.2	-0.1	-0.8	-0.3
Number of children fathered	0.9	1.1	2.7	-1.5	-0.6	0.3	0.5	0.9	-0.6	1.5	1.6	0.3	0.8	1.1	0.7	1.6
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	3.3	-0.3	0.9	1.8	1.7	-1.4	-1.0	0.3	0.2	-0.4	1.8	1.1	1.2	0.6
Age at first live birth	0.5	0.8	2.1	-0.5	-0.8	1.0	1.0	0.3	-0.1	1.3	1.4	0.4	1.2	-0.1	1.0	1.5
Pulse wave peak to peak time	0.9	1.0	4.4	0.6	2.1	0.8	1.0	-0.4	1.0	-1.0	-1.1	0.2	1.2	0.2	1.4	-0.6
Health satisfaction	0.2	0.3	0.7	-0.2	0.9	-0.5	-0.6	-0.6	0.6	-0.5	-0.8	0.2	0.7	0.5	0.2	-0.4
Shortness of breath walking on level ground	1.2	1.5	7.0	-1.5	0.2	0.6	0.8	-0.1	-0.2	1.0	0.7	-0.0	1.8	2.6	1.5	1.2
Qualifications: College or University degree	0.7	2.3	4.4	-0.4	1.1	2.1	2.1	0.7	0.6	1.5	1.6	0.6	2.0	2.0	1.3	2.0
Eye problems/disorders: None of the above	1.3	1.5	4.7	-2.2	0.6	1.1	1.0	-0.2	-2.0	1.0	1.2	-0.8	0.8	1.4	0.1	1.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.5	-0.6	-0.8	-1.5	-1.6	-1.3	-0.9	-0.9	-0.9	-0.8	-1.4	-0.3	-0.3	-1.4
Emphysema/chronic bronchitis	0.2	0.2	0.7	-0.6	-0.8	0.3	0.3	-0.5	0.5	0.1	0.3	-0.8	0.2	0.2	-0.4	0.2
Medication for pain relief, constipation, heartburn	0.3	0.5	1.4	1.1	0.8	-0.1	-0.3	-0.4	0.4	-0.7	-0.8	1.2	-0.3	-0.6	0.7	-0.7
Neck or shoulder pain in last month	0.3	0.4	1.5	-0.2	0.4	-0.6	-0.7	1.0	0.6	0.0	0.2	-0.0	-1.2	-0.2	-0.9	-0.2
Medication: Blood pressure	0.5	0.9	2.2	-0.3	-1.2	0.6	0.3	0.7	0.8	1.4	1.5	-0.1	0.1	1.4	0.7	1.3
Angina (self-reported)	0.5	0.7	2.3	-1.5	-1.1	-0.6	-0.3	0.2	-1.4	0.4	0.1	-1.5	-0.4	0.7	-0.7	-0.1
Migraine (self-reported)	1.1	1.4	5.2	0.2	-2.1	-1.1	-1.1	1.6	0.4	0.4	0.3	0.6	-1.3	-0.7	-2.3	-0.0
Medication: Ibuprofen	0.8	1.0	3.5	-1.9	-1.2	-0.5	-0.6	-0.0	-0.3	-0.3	-0.2	-1.6	0.0	0.8	-1.8	-0.3
Medication: Allopurinol	1.0	1.3	4.6	0.8	-0.8	-0.5	-0.7	2.0	2.1	0.9	1.0	1.7	-0.7	0.6	0.9	0.7
Medication: Omeprazole	0.5	0.6	1.2	-0.2	-0.9	-0.7	-0.8	0.9	0.1	1.0	1.1	0.6	-1.1	-0.2	0.5	0.6
Medication: Seretide 50 evohaler	1.0	1.1	6.6	-0.6	-0.2	0.6	0.7	-2.6	-1.8	-0.7	-1.0	-0.8	0.3	0.1	-0.7	-0.8
Mean time to correctly identify matches	0.7	1.4	5.9	-0.4	-1.5	-2.1	-2.4	0.6	-0.2	-0.4	-0.4	-0.6	-1.9	-0.6	0.2	-1.0
Heart disease (mother)	1.8	2.1	7.0	2.1	1.1	0.6	0.2	1.7	1.4	0.8	0.6	2.6	0.8	0.9	2.6	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	1.3	0.6	-0.4	0.8	0.7	-0.8	1.2	-0.6	-0.6	-0.0	0.7	-0.3	-0.7	-0.3
Whole body fat mass	0.7	3.0	8.6	-1.8	0.2	-0.4	-0.5	2.0	0.9	2.8	2.9	0.8	0.3	1.9	1.5	2.7
Leg fat mass (right)	0.5	2.0	5.7	-1.5	0.2	-1.0	-1.0	1.9	0.8	2.3	2.4	0.6	-0.2	1.2	0.9	2.1
Arm predicted mass (right)	0.3	1.7	6.4	-2.5	1.1	0.6	0.4	-0.1	-0.0	1.7	1.8	-1.1	0.9	1.5	1.0	1.7
Pulse rate, automated reading	0.9	3.1	12.9	1.2	-0.5	0.5	0.4	1.5	3.6	2.4	2.3	2.2	-0.4	0.4	1.5	2.0
Alcohol intake frequency.	0.2	0.4	1.3	-1.0	0.4	0.2	0.9	-1.1	0.2	0.0	0.4	-1.2	0.6	-0.6	0.3	0.5
Comparative height size at age 10	1.0	5.2	11.2	0.0	1.9	2.0	1.8	1.5	1.7	3.3	3.1	2.5	1.8	1.8	2.9	3.4
Number of full sisters	0.4	0.5	2.1	-0.6	0.4	0.7	1.1	-0.6	-0.7	-0.0	0.5	-1.4	0.6	0.5	-0.4	0.5
Suffer from ‘nerves’	0.7	1.1	3.5	1.2	1.9	1.3	1.1	-0.1	1.3	0.7	0.5	1.2	0.9	0.3	0.7	0.8
Overall health rating	0.6	1.2	6.5	-0.2	0.6	1.1	0.9	-2.6	-0.4	-0.9	-1.0	-1.2	1.4	1.1	-0.1	-0.4
Chest pain or discomfort	0.4	0.6	5.2	-0.4	0.0	0.3	0.4	-2.3	-0.7	-0.6	-0.4	-0.9	0.1	-0.0	0.5	-0.4
Had major operations	0.2	0.3	1.1	0.2	0.5	-0.2	-0.4	1.0	0.7	0.5	0.6	0.9	-0.2	0.0	0.4	0.5
Age at last live birth	0.5	0.8	2.3	0.5	-1.0	0.0	0.1	1.2	0.1	1.4	1.5	1.1	-0.0	-0.7	0.2	1.3
Family relationship satisfaction	0.8	1.0	3.5	0.6	0.6	-0.7	-0.5	-0.8	0.8	-1.7	-1.9	-0.5	-0.1	-0.8	-0.1	-1.7
Leg pain on walking	0.5	0.6	1.7	0.2	1.1	1.2	1.3	0.2	-0.2	0.1	0.1	-0.0	0.9	1.0	1.0	0.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	6.4	-1.0	-0.4	1.6	1.6	-2.5	-0.7	-0.3	-0.5	-1.0	1.5	1.0	-0.8	0.0
Commuting to job workplace: Car/motor vehicle	0.1	0.1	1.1	-0.1	-0.2	-0.1	0.0	0.1	-1.0	-0.3	-0.5	-0.2	0.2	0.4	-0.2	-0.4
Illness, injury, bereavement, stress in last 2 years	0.3	0.3	1.2	-0.9	-0.1	-0.1	-0.1	1.1	0.0	0.7	0.8	0.1	-0.0	0.0	0.8	0.7
Medication: Aspirin	0.4	0.6	3.1	-0.3	-0.4	-0.7	-0.4	1.8	0.6	0.9	1.0	-0.2	-0.2	0.1	0.7	0.8
Supplements: Vitamin C	0.4	0.5	1.1	-1.0	-0.2	-0.4	-0.4	0.5	-1.0	1.0	0.5	0.0	-0.8	0.9	-1.0	0.2
Knee pain experienced in last month	0.2	0.4	1.2	0.1	-0.4	1.0	1.1	-0.6	-0.1	-0.4	-0.5	0.1	0.6	0.9	-0.5	-0.2
Hypertension (Self-reported)	0.7	1.9	4.6	1.3	0.8	0.7	0.6	1.8	1.9	1.3	1.7	1.5	-0.1	0.7	2.2	1.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	4.7	-0.1	-1.3	-0.4	-0.1	1.8	1.0	2.2	1.8	1.4	-0.5	-0.2	-0.0	1.5
Illnesses of father: Heart disease	0.8	1.1	4.5	1.6	1.5	0.7	0.6	-0.1	1.6	0.0	0.0	1.2	0.4	0.3	2.1	0.2
Illnesses of siblings: Diabetes	1.3	1.6	5.6	-0.7	-0.2	-0.0	0.1	1.6	1.0	2.4	2.1	0.9	0.1	0.8	1.3	1.9
Smoking status: Previous	0.9	1.3	4.9	-1.4	-1.6	-2.2	-2.0	0.5	-0.4	0.5	0.7	-0.2	-1.5	-0.5	-0.2	0.0
Forced expiratory volume in 1-second (FEV1), predicted	1.9	4.0	8.1	-0.1	1.1	2.2	2.2	0.9	1.1	2.4	2.3	1.5	2.5	2.3	2.4	2.9
Whole body fat-free mass	0.4	2.3	7.1	-2.7	1.4	1.1	0.8	-0.1	0.1	1.9	2.0	-1.3	1.3	1.9	1.0	2.0
Leg fat-free mass (right)	0.5	2.5	6.9	-2.6	1.2	0.9	0.8	0.5	0.2	2.1	2.3	-1.1	1.3	2.1	1.0	2.3
Arm fat percentage (left)	0.6	2.4	6.5	-1.0	-0.3	-1.3	-1.2	2.5	0.5	2.3	2.5	1.1	-0.4	1.3	0.9	2.2
Average weekly red wine intake	0.5	0.8	4.4	0.2	-2.1	-0.1	-0.6	0.6	-0.1	0.0	0.2	-0.2	-1.2	-0.0	-2.0	-0.2
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.8	0.3	1.1	-0.6	-0.4	-0.4	-1.3	-1.3	-1.3	-0.4	-0.3	-0.9	0.7	-1.2
Mood swings	1.6	2.9	6.6	-0.3	0.1	-0.8	-1.0	-2.5	-0.9	-2.3	-2.6	-1.8	-0.7	-0.6	-2.5	-2.6
Loneliness, isolation	0.8	1.1	4.3	-1.1	0.2	1.0	0.9	-1.5	0.8	-0.0	-0.3	-1.3	1.1	2.1	-0.9	0.0
Long-standing illness, disability or infirmity	1.1	1.7	4.5	-1.4	0.3	0.8	1.0	-0.3	0.2	1.3	1.0	-0.0	2.1	2.1	2.0	1.5
Ever had bowel cancer screening	0.9	1.0	3.2	1.2	-0.0	-1.3	-1.1	1.8	1.1	0.1	0.4	0.9	-1.6	-0.8	0.1	-0.1
Diabetes diagnosed by doctor	0.4	0.7	1.9	-0.4	-0.8	0.5	0.6	0.6	-1.0	1.3	1.0	0.1	0.5	1.4	0.6	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.4	1.9	-0.8	-0.5	-0.5	-0.4	0.2	-0.6	-0.2	-0.3	-0.8	-0.4	-0.1	-1.4	-0.5
Friendships satisfaction	1.0	1.3	4.5	0.5	0.8	-0.4	-0.2	-0.7	-0.3	-2.1	-2.0	-1.3	-0.1	-0.7	-1.0	-1.9
Qualifications: nursing, teaching	0.7	1.1	4.9	1.5	-0.3	-0.7	-0.7	2.2	0.2	0.5	0.8	1.5	-1.3	-0.6	0.4	0.4
Commuting to job workplace: Walk	0.5	0.5	1.3	-0.7	0.2	1.0	1.0	-1.1	-0.0	0.3	0.4	-0.5	0.9	0.9	-0.9	0.6
Eye problems/disorders: Cataract	1.6	1.9	4.9	1.5	-0.3	-0.6	-0.7	-1.4	0.4	-2.0	-2.2	-0.4	-0.9	-1.9	-1.1	-2.1
Mouth/teeth dental problems: Mouth ulcers	2.5	4.0	13.5	-2.9	-3.7	-1.3	-1.0	-0.7	-1.9	-0.1	0.2	-3.1	-1.2	-0.3	-3.4	-0.4
Medication for cholesterol	0.4	0.6	2.1	-0.9	-0.1	0.3	0.9	0.3	-0.1	1.3	1.4	-0.0	0.7	0.2	0.3	1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	1.3	-0.6	-0.3	0.1	-0.2	0.4	0.2	1.1	0.5	0.3	0.2	0.9	-0.0	0.5
Back pain experienced in last month	0.7	1.0	3.9	-2.0	0.7	0.3	0.5	-0.4	-0.8	-0.2	-0.4	-1.8	1.2	1.3	-0.4	0.0
Mineral and other dietary supplements	1.3	1.8	5.5	0.2	2.3	1.1	1.6	-0.7	0.2	0.3	0.3	0.2	2.4	1.1	2.3	1.0
Breast cancer (self-reported)	3.4	4.1	15.3	0.2	0.8	-1.2	-0.9	3.9	1.9	2.6	2.8	2.2	-1.4	-0.3	2.3	2.1
Asthma (self-reported)	0.0	0.1	0.4	-0.1	-0.1	-0.4	-0.1	-0.5	0.6	0.2	-0.3	0.2	-0.2	-0.4	-0.3	-0.2
Osteoporosis (self-reported)	0.8	1.0	2.6	-0.5	-0.5	0.1	0.4	-1.3	-0.6	-1.6	-1.6	-1.6	0.4	-0.2	-0.7	-1.4
Osteoarthritis (self-reported)	0.6	0.7	1.9	-0.1	0.1	-1.4	-1.1	0.1	0.4	-0.9	-1.0	-0.8	-1.1	-0.3	-1.0	-1.2
Medication: Aspirin	0.2	0.2	0.9	-0.6	-0.2	-0.4	-0.2	0.9	0.7	0.2	0.3	-0.6	0.1	0.1	0.4	0.2
Medication: Gliclazide	1.6	1.8	5.0	0.8	1.9	2.2	1.9	-0.4	-0.6	0.9	0.3	1.0	1.6	1.4	1.5	0.9
Illnesses of father: None of the above (group 1)	0.5	0.7	2.9	1.0	-0.8	-0.3	-0.4	0.2	-0.9	-0.8	-1.1	0.1	-0.6	-0.2	-1.7	-1.0
Smoking status: Current	1.5	2.4	8.2	-1.4	0.1	2.3	1.9	-2.9	-0.9	0.1	-0.2	-1.6	2.3	1.5	0.0	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.9	2.4	-0.8	-0.7	-1.3	-1.2	0.1	0.3	0.4	1.0	0.8	-0.8	-1.5	1.3	0.6
Whole body water mass	0.4	2.1	6.5	-2.5	1.3	0.9	0.7	-0.0	0.0	1.8	1.9	-1.3	1.2	1.9	0.9	1.9
Leg predicted mass (right)	0.5	2.4	6.3	-2.5	1.2	0.9	0.8	0.5	0.2	2.1	2.3	-1.0	1.2	2.0	1.0	2.3
Arm fat mass (left)	0.5	2.2	6.5	-1.5	0.1	-1.0	-1.0	1.9	0.8	2.3	2.5	0.8	-0.2	1.3	1.0	2.2
Number of self-reported non-cancer illnesses	0.4	0.7	3.8	0.6	-0.8	0.4	0.4	0.9	1.9	0.5	0.1	0.9	0.5	1.5	0.5	0.4
Average weekly champagne plus white wine intake	1.6	2.1	9.2	0.7	1.6	-0.4	-0.4	3.0	1.4	1.5	1.6	1.8	0.1	0.9	1.6	1.5
Miserableness	0.3	0.5	3.1	-0.2	-1.1	-0.4	-0.6	-0.3	-0.2	-0.2	-0.4	-0.0	0.0	0.9	-1.8	-0.3
Guilty feelings	0.1	0.1	0.7	-0.2	0.3	-0.1	-0.4	-0.8	-0.1	-0.0	-0.1	-0.2	-0.2	-0.3	-0.7	-0.2
Wears glasses or contact lenses	0.6	0.7	1.6	0.0	0.3	0.2	0.3	1.0	0.8	1.1	1.3	1.0	0.2	-0.0	1.1	1.2
Ever taken oral contraceptive pill	0.7	0.7	2.5	0.0	0.3	1.6	1.4	-0.6	-0.3	0.4	0.5	-0.2	1.3	1.2	0.6	0.9
Hearing aid user	3.2	3.6	9.9	1.3	-1.5	-2.8	-3.1	0.8	-0.2	-1.8	-1.9	-0.6	-2.6	-1.6	-1.5	-2.4
Mother’s age at death	3.4	4.2	11.5	0.8	-2.1	-3.4	-3.2	1.0	-1.1	-1.5	-1.4	-0.5	-3.0	-2.2	-1.4	-2.2
Financial situation satisfaction	1.7	2.1	8.1	-0.8	0.9	-0.0	0.3	-2.8	-0.6	-2.0	-2.2	-1.9	0.5	-0.3	-1.2	-1.9
Tinnitus: Yes, now most or all of the time	0.6	0.7	3.0	0.1	1.7	1.0	1.1	-0.6	-0.9	-0.3	-0.2	0.3	1.2	0.3	1.0	0.1
Commuting to job workplace: Public transport	1.0	1.2	5.2	-0.1	-0.1	1.5	1.0	-0.3	0.5	1.3	0.8	0.6	1.2	2.3	1.1	1.2
Eye problems/disorders: Glaucoma	0.3	0.3	1.2	-0.2	0.0	-1.0	-0.6	0.7	0.2	-0.4	-0.2	-0.5	-0.7	-1.1	0.1	-0.4
Medication: Blood pressure	0.3	0.5	2.7	0.7	1.6	0.7	0.1	-0.4	0.4	-1.0	-1.0	-0.2	0.2	0.5	-0.1	-0.7
Pain type(s) experienced in last month: Hip pain	0.6	0.8	2.6	-1.6	0.2	-0.1	-0.0	-0.6	-0.9	-1.0	-1.0	-1.6	0.4	0.6	-0.6	-0.9
Supplements: Fish oil (including cod liver oil)	1.6	2.1	7.1	0.4	-1.8	-1.9	-2.2	1.0	-0.6	-0.4	-0.4	0.5	-2.7	-1.7	-1.6	-1.1
High cholesterol (Self-reported)	0.7	1.2	2.7	-1.1	-0.9	-0.9	-0.6	1.6	0.1	1.6	1.6	-0.0	-0.5	1.4	0.8	1.2
Medication: Bendroflumethiazide	0.5	0.7	3.3	0.1	1.8	0.8	0.4	-0.4	1.6	-0.1	0.2	-0.2	0.6	-0.1	1.5	0.4
Medication: Paracetamol	0.5	0.7	2.2	-0.1	0.3	-0.1	-0.4	-1.0	-0.2	-1.1	-1.5	-1.0	0.3	0.2	-1.4	-1.2
Medication: Lisinopril	0.2	0.3	1.3	1.0	0.2	-0.1	-0.3	0.2	0.6	-0.6	-0.1	0.5	-0.1	-1.2	0.8	-0.0
Medication: Atorvastatin	0.3	0.4	1.6	1.0	-0.7	-0.3	-0.3	1.3	0.3	-0.2	-0.3	1.0	-0.1	0.2	1.0	-0.2
Illnesses of father: High blood pressure	0.4	0.5	1.5	0.9	1.1	0.3	0.5	-0.4	0.4	-1.2	-0.9	-0.1	0.2	-1.0	0.4	-0.7
Alcohol drinker status: Never	0.5	0.6	2.6	-1.4	0.6	-0.1	0.4	-0.0	-1.5	-0.4	-0.0	-1.6	0.7	-0.2	0.3	0.1
Ever smoked	0.4	0.7	3.1	-1.8	-1.1	-0.2	-0.4	-1.4	-0.5	-0.1	-0.2	-1.2	0.2	0.3	-0.6	-0.3
Basal metabolic rate	0.4	2.5	6.3	-2.5	1.5	0.9	0.7	0.2	0.2	2.1	2.2	-1.0	1.2	1.9	1.3	2.2
Leg fat percentage (left)	0.5	1.9	5.0	-0.9	-0.1	-1.8	-1.6	2.2	0.8	1.9	2.0	0.9	-1.0	0.8	0.7	1.5
Arm fat-free mass (left)	0.4	1.9	5.5	-2.3	1.1	0.4	0.4	0.2	0.5	1.9	2.1	-0.9	0.9	1.5	1.2	2.0
Number of operations (self-reported)	0.4	0.6	1.4	0.9	-0.6	-0.6	-0.6	0.9	0.7	-0.4	-0.7	0.6	-0.7	-1.1	-1.2	-0.8
Average weekly beer plus cider intake	0.6	0.9	2.6	-1.6	1.5	0.6	0.9	-0.3	-0.3	0.8	1.0	-1.0	0.8	0.3	0.8	1.0
Irritability	0.5	0.8	2.5	-1.0	-0.9	-0.5	-0.7	-1.6	-1.2	-0.4	-0.4	-0.9	-0.1	-0.4	-1.5	-0.4
Risk taking	0.7	1.0	5.3	0.1	-0.4	1.1	0.9	-2.3	-0.1	-0.9	-1.1	-0.7	1.1	1.2	0.0	-0.7
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.8	0.2	-1.3	-0.3	-0.8	-0.5	-0.2	-0.8	-0.9	0.2	-0.6	0.8	-0.5	-1.0
Fractured/broken bones in last 5 years	0.4	0.5	1.9	-1.4	-0.2	0.2	0.4	0.4	-1.1	0.6	0.9	-0.8	0.2	0.9	-0.4	0.7
Age started oral contraceptive pill	1.0	1.2	3.7	0.6	0.9	-1.7	-1.5	0.6	0.1	-1.0	-0.6	-0.4	-1.6	-1.9	0.3	-1.1
Diastolic blood pressure, automated reading	1.2	3.8	8.0	0.7	1.7	1.7	1.3	1.8	1.8	2.3	2.6	2.1	1.5	1.0	2.6	2.8
Ever depressed for a whole week	0.2	0.2	0.6	-0.1	-0.1	0.2	0.4	0.5	-0.1	0.6	0.8	0.5	0.0	-0.3	0.4	0.7
Unable to work because of sickness or disability	1.5	1.9	4.7	-0.8	0.6	1.4	1.3	-1.0	1.1	1.6	1.7	0.7	1.4	1.0	2.2	1.9
Commuting to job workplace: Cycle	0.2	0.3	0.9	0.9	-0.7	-0.0	-0.1	-0.2	0.2	-0.6	-0.9	0.3	0.4	-0.4	-0.3	-0.7
Myopia	0.7	1.0	3.2	-0.8	0.7	1.0	0.9	0.0	0.7	0.7	1.1	-0.5	1.1	1.4	1.8	1.2
Vascular/heart problems diagnosed by doctor	0.5	1.4	4.1	-0.9	-1.0	-0.7	-0.6	-1.3	-1.9	-1.0	-1.3	-1.0	-0.2	-0.8	-2.0	-1.3
Cholesterol lowering medication	0.1	0.2	0.7	0.1	-0.2	-0.0	-0.1	0.7	0.6	0.5	0.1	0.8	-0.1	0.7	0.6	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.1	0.6	-0.9	-0.3	-0.5	0.6	-0.1	0.5	0.5	0.7	-1.0	-0.3	0.1	0.1
Pain experienced in last month	0.6	0.9	2.4	1.5	0.6	0.7	0.9	0.9	1.5	0.6	0.4	1.3	0.3	-0.5	1.4	0.5
Supplements: Calcium	1.7	1.8	5.0	-1.2	-2.2	-0.3	-0.6	-1.5	-1.4	-0.9	-1.5	-1.4	-0.9	-0.1	-2.1	-1.6
Basal cell carcinoma (self-reported)	1.2	1.4	3.1	0.8	-1.7	-1.8	-1.7	0.6	0.8	-1.0	-0.8	-0.3	-1.7	-1.2	-0.6	-1.3
Heart attack/myocardial infarction (self-reported)	1.3	1.7	3.8	-0.3	-0.3	1.3	1.4	-0.3	0.1	1.9	1.7	0.7	1.4	1.3	1.9	1.9
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	3.8	-0.2	0.1	0.3	0.2	-1.7	-2.0	-1.2	-1.0	-0.5	0.7	-0.8	0.1	-0.7
Heart disease (siblings)	1.3	1.6	5.8	-0.5	-0.5	0.4	0.8	2.0	0.9	1.7	1.3	0.5	0.8	2.4	1.3	1.3
Alcohol drinker status: Previous	0.3	0.3	0.9	-0.8	0.7	-0.2	0.1	0.1	0.9	0.5	0.9	-0.6	-0.0	-0.5	0.1	0.7
Pack years of smoking	0.9	1.4	4.4	-0.7	-0.5	-0.1	0.1	-2.1	-2.0	-1.3	-1.3	-1.8	0.0	-0.0	-0.8	-1.2
Impedance of whole body	0.7	3.7	7.1	1.2	1.4	2.5	2.7	0.1	1.4	1.6	1.4	2.5	2.2	1.4	2.7	2.0
Leg fat mass (left)	0.5	2.1	5.8	-1.5	0.1	-1.1	-1.1	2.0	0.9	2.3	2.4	0.6	-0.3	1.2	0.9	2.0
Arm predicted mass (left)	0.3	1.7	5.0	-2.2	1.1	0.6	0.6	-0.0	0.3	1.7	1.9	-1.0	1.0	1.5	1.0	1.8