Hub : Genes

CALCRL

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Aorta	0.1600	0.0540	8.7e-07	0.167	NA	0.087	NA	0.153	1.7e-09	NA	1.6e-05	NA	8.4e-09
2	GTEx	Artery Tibial	0.2744	0.0573	0.0e+00	0.327	NA	0.318	NA	0.321	2.7e-26	NA	2.0e-25	NA	1.1e-25
3	GTEx	Brain Cerebellar Hemisphere	0.1260	0.0570	4.0e-03	0.137	NA	0.091	NA	0.090	2.3e-04	NA	2.5e-03	NA	2.6e-03
4	GTEx	Brain Cerebellum	0.1100	0.0600	8.7e-03	0.100	NA	0.082	NA	0.080	7.1e-04	NA	2.1e-03	NA	2.3e-03
5	GTEx	Nerve Tibial	0.0869	0.0367	4.0e-04	0.045	NA	0.075	NA	0.068	3.9e-04	NA	5.2e-06	NA	1.5e-05
6	NTR	Blood	0.0191	0.0078	3.8e-06	0.026	0.015	0.019	0.015	0.023	7.1e-09	1.0e-05	8.6e-07	9.4e-06	3.6e-08
7	TCGA	Brain Lower Grade Glioma	0.0311	0.0149	5.0e-06	0.039	0.042	0.018	NA	0.031	3.0e-05	1.4e-05	3.3e-03	NA	1.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.1	0.1	0.6	0.3	0.8	0.2	-0.2	0.4	0.1	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.5	1.1	0.3	0.8	1.0	1.1	0.6	0.5	-0.3
Depressed Affect (Nagel 2018)	0.7	1.5	3.1	-1.8	-1.5	0.2	1.0	-1.4	0.6	1.2
Depression (Nagel 2018)	0.1	0.1	0.3	0.0	0.2	0.5	-0.2	0.4	0.3	-0.0
Intelligence (Savage-Jansen 2018)	0.2	0.5	1.5	-0.9	-1.0	0.3	-0.0	-1.2	0.2	0.6
Neuroticism (Nagel 2018)	0.6	1.4	2.6	-1.5	-1.2	0.4	1.6	-0.7	1.1	1.3
Schizophrenia (2018)	0.3	0.6	2.1	0.2	0.4	1.1	1.5	0.5	0.5	-0.2
Schizophrenia vs Biploar Disorder	0.8	1.0	2.0	-1.3	-1.4	0.8	0.6	-1.2	0.8	0.6
Worry (Nagel 2018)	0.9	1.9	3.2	-1.5	-1.4	1.2	1.8	-0.7	1.4	1.3
Alzheimer’s Disease (in mother)	1.3	1.5	4.2	-0.7	-0.8	2.1	0.5	-1.5	1.3	1.0
Alzheimer’s Disease (in father)	0.7	0.8	1.6	1.2	1.2	-0.4	-0.3	0.9	-0.7	-0.8
Alzheimer’s Disease (including proxy)	2.3	3.3	6.2	-1.3	-1.3	2.5	1.6	-2.0	2.2	1.6
Crohns Disease (2017)	0.4	0.9	3.2	0.1	0.3	0.1	1.8	0.4	1.3	1.1
Irritable Bowel Disease (IBD)	0.5	1.2	4.6	0.9	1.1	-0.3	2.1	0.9	0.9	0.5
Ulcerative Colitis (UC)	0.4	0.7	2.6	0.9	0.8	-0.7	1.6	0.3	0.2	0.1
Major Depression (MDD)	0.2	0.3	0.8	-0.1	0.1	0.6	0.9	0.4	-0.6	-0.6
Reaction Time	0.2	0.3	1.0	-0.2	-0.0	1.0	0.3	0.9	0.2	0.3
Verbal and Numeric Reasoning (VNR)	0.1	0.3	0.5	0.5	0.5	-0.2	-0.7	0.5	-0.7	-0.5
Breast Cancer	3.0	7.2	18.7	-3.4	-3.8	0.0	0.8	-4.3	1.5	1.7
Ovarian Cancer	3.7	4.9	7.5	-2.5	-2.7	1.9	1.4	-2.1	2.5	2.1
Prostate Cancer	1.3	1.8	2.6	1.4	1.4	-0.9	-1.5	0.7	-1.6	-1.6
Age at First Birth	0.2	0.4	1.1	0.5	0.2	-0.3	-1.0	-0.2	-0.6	-0.8
Bipolar Disorder (2011)	0.4	0.4	0.9	0.7	1.0	0.1	-0.6	0.2	-0.5	-0.8
Body Mass Index (BMI) (2010)	0.9	1.2	2.9	-0.5	-0.3	1.3	1.7	-0.4	1.4	1.2
Coronary Artery Disease (CAD)	0.2	0.3	0.8	-0.4	-0.4	-0.2	-0.9	-0.9	0.1	0.1
Crohns Disease (2012)	0.5	0.8	1.9	1.0	1.2	-0.5	0.3	1.4	0.8	0.4
Mean Putamen Volume	0.0	0.0	0.2	0.1	-0.0	-0.4	-0.3	0.1	-0.2	-0.0
Fasting Glucose	0.4	0.4	2.5	0.3	-0.1	-0.7	-1.6	0.1	-0.1	-0.1
HbA1C	0.2	0.2	0.7	-0.1	0.1	-0.3	0.3	-0.3	0.7	0.9
HDL Cholesterol	1.1	1.8	2.3	1.5	1.3	-1.5	-1.3	1.2	-1.3	-1.3
LDL Cholesterol	0.2	0.4	2.0	-0.1	-0.2	0.1	1.4	-0.4	0.6	-0.1
Lupus	0.8	1.2	2.8	-0.9	-0.7	1.3	0.6	-0.4	1.4	1.7
Neuroticism (2016)	2.8	4.0	8.8	-2.2	-1.9	0.9	3.0	-1.6	2.0	1.7
Primary Biliary Cirrhosis	2.0	2.8	4.5	1.9	2.1	-0.9	-1.1	1.3	-2.1	-1.9
Rheumatoid Arthritis	0.4	0.6	2.2	0.2	0.1	-1.0	-1.5	-0.3	-0.7	-0.5
Schizophrenia (2014)	0.1	0.2	0.8	0.1	0.4	0.9	0.3	0.0	0.7	0.2
Triglycerides	1.4	2.2	3.0	-1.6	-1.6	0.7	1.6	-1.7	1.6	1.4
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.0	-0.7	-0.5	-1.0	-1.0	-0.9	0.0	0.8
Ulcerative Colitis	0.2	0.3	0.6	0.8	0.7	-0.7	0.7	0.4	0.0	0.0
Blood Eosinophil Count	1.7	12.9	23.2	-4.1	-4.0	2.1	2.2	-3.1	4.1	4.8
Blood Platelet Count	0.0	0.1	0.3	0.3	0.3	0.5	0.1	0.4	0.3	0.5
Blood Red Count	0.7	6.8	11.0	-2.4	-2.1	1.2	2.6	-2.7	3.3	3.3
Blood White Count	5.4	39.8	50.0	-7.0	-7.0	4.8	4.8	-6.3	6.7	7.1
Heel T-Score	2.9	23.3	36.7	5.7	6.1	-3.4	-3.5	5.3	-4.6	-4.6
BMI	0.9	5.0	13.1	-1.4	-1.1	2.4	1.4	-1.1	3.1	3.6
Height	0.8	15.1	25.6	4.8	5.1	-3.1	-2.0	3.7	-3.3	-4.4
Waist Hip Ratio (WHR)	13.1	59.0	104.0	-7.9	-7.8	4.9	6.0	-6.7	9.0	10.2
Systolic Blood Pressure	1.0	5.2	7.3	-2.4	-2.6	-0.8	2.7	-2.2	2.2	2.4
Smoking Status	0.5	1.1	2.7	1.6	1.3	0.3	0.1	1.6	-0.2	-0.7
Allergy or Eczema	7.8	20.5	28.9	5.4	5.4	-3.9	-2.9	4.8	-4.5	-4.4
Cardiovascular Disease	4.6	15.2	20.6	-4.1	-3.7	2.3	4.3	-3.6	4.3	4.5
Hypothyroidism (self reported)	1.5	3.4	6.7	-2.4	-2.6	0.6	1.5	-2.4	1.0	1.5
Respiratory disease	0.7	1.6	7.6	0.9	1.0	-2.8	-0.9	0.9	-0.5	0.2
Type 2 Diabetes (T2D) (2018)	0.1	0.3	0.7	-0.0	-0.2	-0.8	0.4	-0.4	0.4	0.8
Lung FEV1/FVC ratio	4.8	24.6	31.2	-5.6	-4.8	4.7	3.9	-5.2	5.3	5.0
Lung FVC	2.0	10.3	17.1	3.7	3.4	-1.3	-1.8	3.4	-3.6	-4.1
Neuroticism	0.5	1.1	3.9	-1.0	-0.9	0.4	2.0	-0.4	0.9	0.8
Chronotype (morning person)	0.9	2.0	4.1	1.3	1.0	-0.7	-1.1	1.3	-2.0	-2.0
Hair Pigment	0.1	1.8	6.5	-1.4	-1.4	-1.0	-1.1	-2.5	0.1	0.2
Tanning	0.0	0.5	1.0	-0.8	-0.7	1.0	-0.2	-0.5	0.8	-0.0
Hand grip strength (left)	3.1	8.1	11.6	3.3	3.4	-2.4	-1.9	2.4	-2.9	-3.2
Number of treatments/medications taken	0.6	1.0	2.9	-0.4	-0.3	0.1	1.7	-0.3	1.5	1.4
Average weekly spirits intake	0.2	0.3	1.0	-0.5	-0.3	0.4	-0.0	-0.2	0.7	1.0
Sensitivity / hurt feelings	0.4	0.7	1.9	0.9	0.9	-0.3	1.4	1.3	0.3	-0.0
Frequency of depressed mood in last 2 weeks	1.3	1.8	2.9	-1.3	-1.2	1.3	1.7	-1.1	1.6	1.1
Hearing difficulty/problems: Yes	0.2	0.3	0.8	0.1	0.2	-0.7	-0.3	0.9	-0.8	-0.4
Relative age of first facial hair	0.8	1.6	2.6	-1.6	-1.3	0.5	1.2	-1.4	1.0	1.5
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.9	0.6	0.4	-0.9	-0.0	0.4	-0.9	-0.7
Ever used hormone-replacement therapy (HRT)	0.2	0.2	0.4	0.7	0.5	-0.2	0.2	0.6	-0.5	-0.5
Ever had hysterectomy (womb removed)	2.6	2.9	4.7	2.0	1.9	-0.8	-1.8	2.2	-1.1	-1.7
Systolic blood pressure, automated reading	0.2	0.5	1.9	0.1	0.0	-1.4	0.8	0.2	0.4	0.8
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.6	-0.1	-0.3	-0.8	0.8	0.2	0.3	0.2
Angina	3.1	4.0	6.2	-2.4	-2.5	1.4	1.9	-1.8	2.0	1.9
Medication for hormone replacement therapy	0.8	0.9	3.6	0.9	1.0	0.2	0.5	1.9	-0.5	-0.4
Vitamin and mineral supplements	0.3	0.3	1.1	-0.1	-0.3	1.0	-0.2	0.9	-0.4	-0.5
Supplements: Zinc	0.5	0.5	1.1	0.8	1.0	-1.0	0.5	0.5	-0.2	0.3
Medication: Co-codamol	0.2	0.2	0.7	0.3	0.4	-0.1	-0.9	0.2	-0.5	-0.5
Medication: Metformin	0.3	0.5	1.8	-0.3	-0.3	-1.3	-0.3	-0.9	0.2	0.6
Diabetes (father)	0.5	0.6	1.1	0.7	0.8	-1.0	-0.7	1.0	0.2	0.5
Diabetes (mother)	0.3	0.4	0.8	-0.8	-0.7	-0.0	-0.4	-0.9	0.1	0.9
Severe depression (siblings)	0.8	0.8	4.2	-0.3	-0.1	0.1	2.0	0.4	1.0	0.7
Pack years adult smoking proportion	0.4	0.6	1.5	-1.0	-1.2	0.2	0.4	-0.4	0.8	0.7
Impedance of leg (right)	0.9	4.3	8.3	-2.5	-2.9	-0.5	1.8	-2.8	1.3	1.6
Leg fat-free mass (left)	0.2	0.9	2.2	1.1	1.5	0.9	0.0	1.2	0.5	-0.1
Trunk fat percentage	0.6	2.3	6.1	-1.0	-0.8	1.4	0.7	-0.6	2.4	2.5
Hand grip strength (right)	1.8	4.8	6.9	2.5	2.6	-2.1	-0.9	1.9	-2.3	-2.4
Townsend deprivation index at recruitment	0.4	0.6	1.5	-0.6	0.1	0.8	0.9	-0.4	0.8	1.2
Current tobacco smoking	1.7	2.9	8.3	2.1	2.0	0.5	-0.2	2.9	-1.0	-1.3
Average weekly fortified wine intake	0.1	0.1	0.3	0.0	0.0	-0.6	0.2	0.2	-0.2	0.0
Maternal smoking around birth	0.2	0.3	0.7	-0.2	-0.3	0.7	0.8	0.8	0.5	0.2
Fed-up feelings	1.7	3.1	4.7	-2.0	-1.9	0.4	2.2	-1.4	1.8	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.1	0.1	0.1	0.8	1.1	0.1	0.8	0.1
Relative age voice broke	1.1	1.7	2.8	0.9	1.3	-1.7	-1.5	0.9	-1.7	-0.8
Taking other prescription medications	0.3	0.5	1.2	-0.2	-0.3	0.3	0.9	-0.6	1.1	1.0
Age when periods started (menarche)	0.3	0.6	1.4	0.8	0.9	-1.2	-0.4	0.7	-0.4	-0.9
Bilateral oophorectomy (both ovaries removed)	9.7	11.3	17.0	4.1	3.9	-2.1	-2.3	4.1	-3.2	-3.1
Heel bone mineral density (BMD) T-score, automated (left)	4.1	9.2	15.2	3.7	3.9	-1.6	-2.2	3.9	-2.4	-2.8
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.7	0.5	0.8	0.3	-0.1	0.6	-0.5	-0.4
Qualifications: CSEs or equivalent	0.7	1.0	1.7	-0.8	-0.7	1.1	1.3	-0.5	1.1	1.2
Serious illness, injury or assault to yourself	0.2	0.3	1.7	-0.1	-0.1	-0.3	1.3	0.2	0.2	0.2
High blood pressure	3.4	9.5	14.8	-2.9	-2.7	2.4	3.7	-1.7	3.8	3.9
Hayfever, allergic rhinitis or eczema	5.3	11.6	17.5	3.9	4.2	-2.7	-2.1	3.9	-3.4	-3.2
Multivitamins +/- minerals	0.2	0.3	0.7	0.7	0.6	-0.8	0.1	-0.2	-0.2	-0.6
Stomach or abdominal pain in last month	1.3	1.6	4.2	-1.3	-1.8	-1.0	0.7	-2.1	0.4	0.8
Supplements: Glucosamine	0.6	0.8	1.9	-1.1	-1.1	0.2	0.9	-1.4	0.6	0.4
Diverticular disease/diverticulitis (self-reported)	0.8	0.9	2.0	1.4	1.2	-1.0	-0.4	0.9	-0.7	-0.7
Medication: Atenolol	2.3	2.9	4.7	-1.4	-1.5	2.2	1.7	-1.1	2.0	1.7
Medication: Levothyroxine sodium	1.9	3.2	5.0	-1.9	-2.0	1.2	2.2	-2.2	1.3	1.2
Sitting height	3.4	24.3	36.1	5.6	5.7	-3.6	-3.3	4.6	-5.0	-6.0
Chronic bronchitis/emphysema (father)	0.4	0.5	1.0	0.9	0.6	0.2	0.1	1.0	-0.6	-0.8
High blood pressure (mother)	0.2	0.3	0.9	-0.1	0.4	-0.8	0.9	-0.1	0.4	0.4
Body mass index (BMI)	1.7	7.1	14.3	-2.1	-1.8	3.2	1.7	-1.3	3.6	3.8
Impedance of leg (left)	0.8	4.0	9.4	-2.4	-2.8	-0.6	1.5	-3.1	1.0	1.2
Leg predicted mass (left)	0.2	0.9	2.4	1.2	1.6	0.9	0.0	1.3	0.5	-0.1
Trunk fat mass	0.7	2.9	7.3	-1.1	-0.8	1.8	0.9	-0.6	2.7	2.6
Waist circumference	5.5	20.2	35.3	-4.5	-4.2	3.9	2.6	-3.8	5.6	5.9
Number of incorrect matches in round	0.2	0.3	0.8	0.1	0.2	0.9	0.4	0.5	0.8	0.6
Past tobacco smoking	0.2	0.3	0.6	0.1	0.4	-0.5	-0.8	-0.3	-0.7	-0.7
Alcohol usually taken with meals	0.3	0.5	1.5	0.7	0.4	-0.8	0.1	0.1	-1.2	-0.8
Nervous feelings	1.2	2.2	4.2	-1.6	-1.5	0.6	2.1	-0.9	1.8	1.5
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.4	6.5	-2.0	-1.8	1.0	2.5	-2.1	1.9	1.2
Hearing difficulty/problems with background noise	0.5	0.8	2.3	-1.5	-1.5	0.1	0.3	-1.0	-0.1	0.5
Hair/balding pattern: Pattern 2	0.6	0.8	2.7	-0.0	0.1	-1.1	-1.6	-0.4	-1.1	-0.3
Had menopause	0.3	0.4	0.7	0.8	0.4	-0.5	-0.5	0.2	-0.7	-0.8
Had other major operations	0.6	0.7	1.9	0.5	0.7	0.3	1.1	1.4	0.7	0.5
Forced vital capacity (FVC)	2.0	7.7	15.3	2.8	2.4	-2.4	-2.0	1.7	-3.6	-3.9
Heel bone mineral density (BMD) T-score, automated (right)	2.5	5.7	10.7	3.1	3.3	-1.0	-1.4	3.0	-1.6	-2.2
Ever unenthusiastic/disinterested for a whole week	1.7	2.1	3.0	-1.7	-1.3	0.6	1.5	-1.7	1.4	1.4
Qualifications: None of the above	0.1	0.3	0.6	-0.7	-0.6	0.3	-0.3	0.8	0.4	0.6
Financial difficulties in last 2 years	1.0	1.3	3.7	-1.1	-0.8	0.8	1.9	-1.3	1.2	0.4
Mouth/teeth dental problems	0.3	0.5	1.7	0.8	1.0	-0.1	-0.5	1.3	-0.3	-0.2
Heart attack	2.1	2.7	4.8	-2.2	-2.1	1.1	1.1	-1.1	1.7	1.8
Allergy	2.4	5.5	7.2	-2.6	-2.6	2.7	1.8	-2.4	2.2	2.0
Pain all over the body in last month	0.1	0.1	0.4	-0.6	-0.6	0.3	-0.0	-0.3	-0.4	-0.1
Diabetes (self-reported)	0.1	0.2	1.3	-0.1	-0.2	-1.1	-0.1	-0.4	0.1	0.2
Hayfever/allergic rhinitis (self-reported)	3.1	4.1	5.5	2.3	2.4	-1.5	-2.2	2.1	-1.7	-1.9
Medication: Ramipril	3.5	4.5	8.0	-2.1	-1.9	1.9	2.2	-1.1	2.8	2.4
Medication: Simvastatin	4.1	6.1	9.9	-3.1	-3.0	0.9	2.2	-2.7	2.3	2.3
Fluid intelligence score	0.4	0.8	1.3	-0.6	-0.7	1.1	1.1	-1.1	0.5	0.8
Illnesses of siblings	0.3	0.4	1.5	-0.4	-0.5	1.2	0.6	-0.8	0.2	-0.1
Neuroticism score	0.8	1.8	5.7	-1.2	-1.0	0.6	2.4	-0.6	1.4	1.3
Weight	0.6	2.9	7.4	-0.9	-0.5	2.1	1.2	-0.5	2.7	2.4
Impedance of arm (right)	2.3	10.7	15.9	3.7	3.3	-4.0	-1.7	2.9	-3.4	-3.5
Arm fat percentage (right)	0.5	2.2	6.3	-0.7	-0.4	1.4	0.9	-0.0	2.3	2.5
Trunk fat-free mass	0.3	1.7	4.4	-0.5	-0.1	2.1	1.3	-0.0	2.0	1.2
Hip circumference	0.1	0.5	1.3	-0.4	-0.2	1.1	-0.6	-0.6	0.9	0.6
Time employed in main current job	0.2	0.2	0.6	0.3	0.2	-0.1	-0.6	0.4	-0.7	-0.8
Alcohol intake versus 10 years previously	1.8	2.7	4.2	-1.9	-2.0	1.3	1.1	-1.3	1.6	2.0
Father’s age at death	1.7	2.3	6.0	0.8	0.6	-1.2	-1.3	0.1	-2.4	-2.5
Worrier / anxious feelings	0.3	0.5	2.4	0.0	0.3	0.8	1.5	0.7	0.4	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	1.0	-0.5	-0.4	-0.3	1.0	-0.7	0.4	0.2
Falls in the last year	0.1	0.2	0.6	-0.4	-0.7	0.6	-0.2	0.0	-0.1	-0.4
Hair/balding pattern: Pattern 3	0.7	1.1	4.9	0.2	0.5	1.0	2.2	0.4	0.9	0.7
Number of live births	1.2	1.6	2.4	-1.2	-1.2	1.3	1.1	-1.4	1.5	1.1
Forced expiratory volume in 1-second (FEV1)	0.8	2.8	7.6	1.4	1.3	-1.2	-1.1	0.3	-2.4	-2.8
Pulse rate	5.1	8.6	19.0	3.6	4.4	-0.9	-1.6	4.3	-1.8	-1.9
Happiness	1.2	1.4	2.2	-1.5	-1.4	-0.5	1.1	-1.3	1.1	1.2
Noisy workplace	2.3	2.9	4.4	1.4	1.4	-1.2	-1.9	1.9	-1.9	-2.1
Qualifications: A levels/AS levels or equivalent	0.9	2.0	3.7	1.5	1.4	-1.4	-1.1	0.1	-1.7	-1.9
Serious illness, injury or assault of a close relative in last 2 years	0.3	0.3	1.0	-0.0	-0.2	-0.3	-0.3	-0.5	-1.0	-0.9
Mouth/teeth dental problems: Dentures	0.1	0.1	0.6	-0.1	0.1	0.5	0.1	0.8	-0.2	-0.2
Asthma	0.3	0.6	3.2	0.4	0.5	-1.8	-0.4	0.4	-0.1	0.1
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.9	-0.1	-0.0	0.8	0.9	-0.3	0.5	0.0
Medication: Cholesterol lowering	1.9	2.9	5.1	-1.8	-1.8	0.6	1.8	-1.0	2.3	2.1
Depression (self-reported)	1.7	2.1	6.2	-1.3	-1.2	0.3	2.5	-1.7	1.1	1.0
Medication: Lansoprazole	0.0	0.0	0.1	-0.1	-0.1	-0.1	0.3	-0.0	-0.0	0.0
Prospective memory result	0.2	0.2	0.7	-0.7	-0.8	0.3	-0.0	-0.7	0.1	-0.1
Lung cancer (father)	0.4	0.4	1.3	0.2	0.6	0.1	-0.4	0.4	-1.0	-1.1
Illnesses of mother	1.0	1.2	2.1	0.8	0.4	-0.4	-1.5	1.2	-1.4	-1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	1.0	2.7	0.8	0.8	-0.6	-0.8	-0.0	-1.3	-1.6
Pulse wave Arterial Stiffness index	2.5	2.9	3.9	-1.9	-1.9	1.2	0.8	-1.7	2.0	2.0
Impedance of arm (left)	2.7	12.4	19.1	3.6	3.2	-4.4	-2.6	2.5	-4.0	-3.9
Arm fat mass (right)	0.8	3.3	8.0	-1.1	-0.7	2.2	1.1	-0.4	2.8	2.7
Trunk predicted mass	0.3	1.6	4.4	-0.4	-0.0	2.1	1.3	0.1	2.0	1.2
Standing height	0.4	4.0	7.0	2.5	2.6	-1.8	-0.6	1.6	-1.5	-2.6
Length of working week for main job	2.6	2.8	5.6	1.5	1.6	-2.4	-1.1	2.2	-1.4	-1.1
Exposure to tobacco smoke at home	0.4	0.4	1.2	-0.2	-0.0	0.9	1.1	0.3	0.6	0.5
Breastfed as a baby	0.4	0.4	1.9	-0.5	-0.7	-0.5	-0.1	-1.4	0.4	0.2
Tense / ‘highly strung’	1.0	1.7	3.3	-1.4	-1.8	-0.1	1.4	-1.4	1.2	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	0.8	-0.8	-0.8	-0.5	0.3	-0.9	0.0	-0.0
Hair/balding pattern: Pattern 4	0.1	0.3	1.0	-0.3	-0.5	1.0	0.3	-0.5	0.5	0.2
Birth weight of first child	1.3	2.4	3.6	1.8	1.5	-1.4	-1.4	0.6	-1.8	-1.9
Peak expiratory flow (PEF)	0.1	0.2	1.2	-0.1	-0.2	-0.3	-0.2	-1.1	-0.4	-0.3
Pulse wave reflection index	4.6	5.7	6.8	-2.5	-2.5	2.1	1.9	-2.3	2.6	2.5
Ever highly irritable/argumentative for 2 days	1.6	1.9	2.7	-1.6	-1.4	0.9	1.4	-1.1	1.4	1.6
Loud music exposure frequency	0.8	0.9	2.7	0.6	0.5	0.1	-1.3	1.6	-0.8	-0.9
Qualifications: O levels/GCSEs or equivalent	1.5	2.3	4.1	2.0	1.9	-0.9	-0.9	0.8	-1.7	-1.9
Mouth/teeth dental problems: Bleeding gums	0.8	1.0	2.7	-0.5	-0.6	1.3	1.6	-0.7	1.1	0.8
Blood clot in the leg (DVT)	1.7	2.2	4.1	-1.6	-2.0	1.1	0.6	-1.6	1.4	1.6
Medication: Paracetamol	0.8	1.4	3.0	1.4	1.5	0.0	0.3	1.7	-1.1	-1.2
Headache pain in last month	0.2	0.4	1.5	0.4	0.2	-1.2	-0.3	-0.6	-0.5	-0.7
Medication for cholesterol, blood pressure or diabetes	1.4	2.3	4.7	1.5	1.3	-0.4	-1.7	0.6	-2.2	-2.1
Glaucoma (self-reported)	0.5	0.5	2.5	-0.3	-0.2	0.0	0.7	-0.2	0.8	1.6
Gout (self-reported)	0.4	0.5	0.8	0.3	0.7	-0.9	-0.8	-0.7	-0.9	-0.6
Hypothyroidism/myxoedema (self-reported)	2.0	4.0	6.0	-2.3	-2.5	1.1	2.0	-2.2	1.6	1.9
Medication: Amlodipine	1.6	2.3	3.3	-1.6	-1.4	0.9	1.8	-0.8	1.8	1.8
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.7	-0.2	-0.2	0.3	0.8	-0.2	0.8	0.8
Birth weight	1.0	2.2	5.0	1.6	1.6	-0.2	-0.8	1.6	-1.4	-2.2
Chronic bronchitis/emphysema (mother)	0.3	0.3	0.9	-1.0	-0.8	0.2	0.2	0.2	0.4	0.7
High blood pressure (siblings)	0.4	0.6	1.3	0.8	1.0	-1.1	-0.5	0.6	-0.5	-0.4
Forced vital capacity (FVC), Best measure	2.1	7.5	12.6	2.9	2.6	-2.6	-2.3	1.7	-3.2	-3.5
Body fat percentage	1.2	4.7	10.6	-1.8	-1.6	1.9	1.2	-1.2	3.0	3.3
Leg fat percentage (right)	4.1	15.0	26.4	-3.9	-3.7	3.5	2.7	-2.8	4.7	5.1
Arm fat-free mass (right)	0.5	2.5	5.4	-1.3	-0.9	2.3	0.9	-1.0	2.2	1.6
Exposure to tobacco smoke outside home	0.4	0.5	2.2	0.0	-0.3	1.5	0.9	0.4	0.5	0.2
Comparative body size at age 10	5.7	15.7	29.2	-3.4	-3.0	3.4	4.1	-2.7	5.4	5.0
Number of full brothers	0.4	0.5	1.2	-1.0	-1.1	1.0	0.1	-0.3	0.5	0.5
Worry too long after embarrassment	0.2	0.3	0.9	-0.3	-0.1	0.3	1.0	0.0	0.8	0.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	5.9	-2.2	-1.7	0.6	0.7	-2.4	0.9	1.3
Wheeze or whistling in the chest in last year	1.5	2.7	5.3	-1.7	-1.7	0.7	1.7	-0.7	1.9	2.3
Number of children fathered	1.5	1.7	2.8	-1.6	-1.5	1.4	-0.2	-0.8	1.4	1.7
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	3.0	-1.3	-1.1	0.8	1.7	-0.7	1.6	1.5
Age at first live birth	0.1	0.2	0.5	0.4	0.5	-0.3	-0.2	-0.7	-0.6	-0.4
Pulse wave peak to peak time	2.8	3.3	4.6	2.1	2.0	-1.4	-0.9	1.7	-2.1	-2.1
Health satisfaction	3.3	4.3	6.8	-2.3	-1.8	0.3	2.6	-1.7	2.4	2.5
Shortness of breath walking on level ground	0.4	0.4	1.4	-0.5	0.2	0.5	0.8	0.4	0.5	1.2
Qualifications: College or University degree	0.4	1.2	3.1	0.6	0.4	-1.8	-1.0	-1.0	-1.2	-1.3
Eye problems/disorders: None of the above	0.1	0.1	0.2	-0.3	-0.1	0.3	0.3	-0.4	0.2	0.2
Mouth/teeth dental problems: Loose teeth	0.7	0.8	2.7	-0.7	-1.0	-1.2	0.2	-1.6	-0.2	0.3
Emphysema/chronic bronchitis	0.5	0.5	1.7	0.5	0.7	-0.8	-0.7	1.3	-0.5	0.1
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	-0.6	-0.3	-0.1	-0.2	-0.6	0.2	0.6
Neck or shoulder pain in last month	0.7	1.0	2.3	-1.1	-1.5	-0.1	0.3	-1.2	0.9	1.1
Medication: Blood pressure	1.5	2.7	5.4	-1.9	-1.5	0.5	1.7	-1.0	1.9	2.3
Angina (self-reported)	1.9	2.5	4.5	-2.0	-2.1	1.2	1.4	-1.2	1.5	1.5
Migraine (self-reported)	1.3	1.6	3.6	0.7	0.9	-1.3	-1.2	0.1	-1.9	-1.7
Medication: Ibuprofen	0.4	0.4	0.8	0.8	0.8	0.9	0.8	0.5	0.1	-0.5
Medication: Allopurinol	1.1	1.4	4.2	-1.5	-0.9	0.5	0.5	-2.1	0.7	1.3
Medication: Omeprazole	1.1	1.3	2.7	-1.1	-1.0	1.7	0.1	-0.5	1.2	1.6
Medication: Seretide 50 evohaler	1.8	2.0	5.4	1.0	0.9	-2.3	-1.6	0.9	-1.5	-1.3
Mean time to correctly identify matches	0.3	0.5	1.8	0.5	0.6	0.3	-0.8	1.4	-0.5	-0.3
Heart disease (mother)	0.2	0.3	0.7	0.5	0.8	-0.8	0.4	-0.2	-0.2	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.5	1.0	0.5	0.5	-0.5	-1.0	0.9	-1.0	-0.6
Whole body fat mass	1.2	5.0	11.0	-1.7	-1.4	2.3	1.4	-1.2	3.3	3.3
Leg fat mass (right)	2.5	9.5	17.6	-2.8	-2.5	3.1	2.1	-2.0	4.1	4.2
Arm predicted mass (right)	0.6	2.8	6.0	-1.4	-1.0	2.5	1.0	-1.0	2.4	1.8
Pulse rate, automated reading	19.4	62.7	104.0	9.8	10.2	-4.5	-4.5	9.8	-6.9	-7.5
Alcohol intake frequency.	3.7	8.7	14.2	-3.0	-2.6	3.5	2.3	-2.1	3.0	3.8
Comparative height size at age 10	0.2	1.1	2.9	1.1	0.8	-0.8	-1.0	0.3	-0.9	-1.7
Number of full sisters	0.3	0.4	0.7	0.6	0.8	-0.6	-0.6	0.8	-0.3	-0.1
Suffer from ‘nerves’	0.8	1.3	2.2	-1.4	-1.3	0.0	1.5	-1.1	1.1	0.9
Overall health rating	0.5	1.1	2.0	-1.4	-1.4	-0.8	0.6	-1.0	0.7	1.0
Chest pain or discomfort	0.7	1.1	2.4	-1.3	-1.6	-0.5	-1.3	-1.0	-0.6	-0.4
Had major operations	0.4	0.5	1.7	-0.2	0.1	1.3	0.2	0.3	0.9	1.0
Age at last live birth	0.7	0.9	3.8	-1.1	-1.1	-0.0	0.1	-1.9	0.4	0.5
Family relationship satisfaction	1.2	1.5	2.5	-1.5	-1.1	0.3	1.4	-1.0	1.2	1.6
Leg pain on walking	0.1	0.1	0.4	0.1	0.5	0.1	0.0	0.6	-0.1	-0.0
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.8	-1.4	-1.2	0.6	1.1	-1.3	0.9	0.9
Commuting to job workplace: Car/motor vehicle	0.6	0.7	2.2	1.0	1.0	0.4	0.1	1.5	-0.3	-0.5
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.4	0.6	0.8	-1.1	0.1	1.2	0.2	0.4
Medication: Aspirin	1.4	1.9	4.8	-1.6	-2.2	-0.1	0.8	-1.7	1.1	0.9
Supplements: Vitamin C	0.2	0.3	0.5	0.6	0.6	-0.4	0.7	0.3	0.4	0.6
Knee pain experienced in last month	0.2	0.3	0.7	-0.1	-0.6	-0.9	-0.4	-0.5	-0.5	-0.8
Hypertension (Self-reported)	4.6	12.9	19.6	-3.5	-3.2	2.8	4.1	-2.3	4.3	4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	1.6	-0.9	-0.8	1.2	0.1	-0.6	1.3	1.3
Illnesses of father: Heart disease	2.3	3.2	6.3	-1.5	-1.5	2.5	1.2	-1.4	2.1	1.9
Illnesses of siblings: Diabetes	0.4	0.4	1.6	-0.3	-0.2	-0.3	0.8	0.0	0.7	1.3
Smoking status: Previous	0.8	1.2	1.8	-1.1	-1.1	1.0	1.1	-0.6	1.3	1.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.7	1.8	1.2	1.3	-0.9	0.3	0.7	0.1	-0.7
Whole body fat-free mass	0.1	0.8	2.6	0.2	0.6	1.6	0.7	0.5	1.4	0.6
Leg fat-free mass (right)	0.2	1.2	3.5	1.5	1.9	0.6	-0.2	1.4	0.1	-0.6
Arm fat percentage (left)	0.4	1.8	5.2	-0.6	-0.4	1.4	0.5	-0.1	2.1	2.3
Average weekly red wine intake	1.0	1.5	3.7	1.4	1.4	0.3	-0.1	1.1	-1.1	-1.9
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.3	-1.0	-1.1	0.6	1.1	-0.9	1.1	1.1
Mood swings	0.6	1.1	3.0	-1.1	-0.9	0.2	1.7	-1.0	0.8	1.1
Loneliness, isolation	0.8	1.2	2.9	-1.2	-0.9	0.5	1.7	-1.2	0.7	0.9
Long-standing illness, disability or infirmity	0.4	0.6	1.6	0.7	0.7	-1.3	-0.6	0.8	-0.7	-0.5
Ever had bowel cancer screening	3.6	4.2	8.2	-1.8	-1.8	1.4	1.3	-2.0	2.6	2.9
Diabetes diagnosed by doctor	0.4	0.7	2.9	0.0	-0.1	-1.7	-1.1	-0.3	-0.6	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.2	0.5	-0.1	-0.4	-0.7	0.5	-0.7	-0.1	-0.4
Friendships satisfaction	0.5	0.6	1.2	-1.0	-1.0	0.1	0.3	-0.7	0.7	1.1
Qualifications: nursing, teaching	0.3	0.5	2.6	0.2	0.1	-0.4	-1.6	-0.6	-0.6	-0.3
Commuting to job workplace: Walk	0.2	0.2	0.8	-0.3	-0.3	-0.6	0.3	-0.9	0.3	0.3
Eye problems/disorders: Cataract	0.5	0.6	1.8	0.4	0.2	-0.4	-0.4	0.4	-1.3	-1.4
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	0.9	0.9	0.8	-0.9	-0.9	-0.0	-0.8	-0.8
Medication for cholesterol	3.1	4.7	7.2	2.4	2.3	-1.4	-2.2	1.3	-2.5	-2.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.1	0.7	0.6	1.1	0.5	0.6	0.2	0.2
Back pain experienced in last month	0.1	0.2	0.4	-0.6	-0.7	0.4	0.4	-0.4	-0.3	-0.4
Mineral and other dietary supplements	0.1	0.2	0.7	-0.1	-0.3	0.8	0.6	0.5	0.0	0.1
Breast cancer (self-reported)	3.0	3.6	6.1	2.2	2.1	-0.4	-0.6	2.5	-1.9	-2.4
Asthma (self-reported)	0.3	0.5	2.9	0.4	0.6	-1.7	-0.3	0.5	-0.1	0.1
Osteoporosis (self-reported)	1.3	1.6	3.7	-0.8	-0.6	1.7	1.1	-0.7	1.9	1.5
Osteoarthritis (self-reported)	0.6	0.7	2.7	-0.3	-0.6	1.6	0.5	0.1	1.1	0.8
Medication: Aspirin	1.7	2.3	5.2	-1.8	-2.3	0.1	0.9	-1.9	1.3	1.1
Medication: Gliclazide	0.8	0.9	2.6	-0.7	-0.7	0.3	1.6	0.3	1.2	1.2
Illnesses of father: None of the above (group 1)	1.1	1.3	2.9	1.3	1.7	-0.1	-0.5	1.2	-1.2	-1.2
Smoking status: Current	2.0	3.2	8.9	2.3	2.2	0.3	-0.5	3.0	-0.9	-1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.9	4.1	7.1	2.1	2.2	-0.5	-2.7	1.3	-2.2	-2.3
Whole body water mass	0.2	0.9	2.7	0.1	0.5	1.6	0.7	0.5	1.4	0.6
Leg predicted mass (right)	0.2	1.3	3.7	1.5	1.9	0.5	-0.3	1.4	-0.0	-0.7
Arm fat mass (left)	0.8	3.1	7.6	-1.1	-0.7	2.0	1.0	-0.6	2.8	2.7
Number of self-reported non-cancer illnesses	1.3	2.2	3.1	-1.6	-1.4	0.5	1.3	-1.7	1.8	1.8
Average weekly champagne plus white wine intake	0.8	1.1	3.2	1.4	1.8	0.2	-0.1	1.3	-0.6	-0.5
Miserableness	0.5	0.8	2.3	-0.9	-0.8	0.6	1.5	-0.4	0.9	0.9
Guilty feelings	0.2	0.3	1.0	-0.1	-0.2	-0.4	0.7	0.4	-0.6	-1.0
Wears glasses or contact lenses	1.1	1.3	3.9	1.2	1.1	-2.0	-0.4	0.5	-0.9	-1.0
Ever taken oral contraceptive pill	0.6	0.7	1.7	1.3	1.2	-0.6	-0.7	0.4	-0.7	-0.7
Hearing aid user	0.9	1.1	3.5	1.1	1.1	-1.0	-0.5	1.9	-0.6	-0.2
Mother’s age at death	0.3	0.3	0.9	0.3	0.2	-0.2	-0.8	0.5	-1.0	-0.6
Financial situation satisfaction	4.3	5.3	7.5	-2.7	-2.2	1.2	2.3	-2.3	2.7	2.4
Tinnitus: Yes, now most or all of the time	0.1	0.2	0.7	0.4	0.3	-0.0	-0.8	0.2	0.3	0.3
Commuting to job workplace: Public transport	1.1	1.3	3.3	-1.0	-1.1	0.5	1.0	-1.8	1.0	1.1
Eye problems/disorders: Glaucoma	0.3	0.4	1.8	-0.4	-0.3	0.3	0.5	-0.3	0.6	1.3
Medication: Blood pressure	4.1	7.9	12.3	-2.6	-2.8	2.2	3.0	-1.7	3.5	3.3
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.8	0.3	0.2	0.5	0.9	-0.0	-0.3	-0.8
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.4	0.2	0.5	-0.5	-0.4	-0.5	0.4	0.6
High cholesterol (Self-reported)	3.3	5.9	8.5	-2.9	-2.6	1.4	2.1	-2.9	2.3	2.4
Medication: Bendroflumethiazide	2.9	4.4	8.6	-1.3	-1.2	1.8	2.9	-0.6	2.8	2.8
Medication: Paracetamol	0.8	1.3	3.0	1.2	1.3	-0.2	1.2	1.7	-0.7	-0.9
Medication: Lisinopril	2.7	3.6	6.5	-2.1	-1.7	1.4	1.4	-1.4	2.5	2.3
Medication: Atorvastatin	4.9	6.0	8.9	-2.8	-3.0	1.6	2.1	-2.5	2.7	2.2
Illnesses of father: High blood pressure	1.3	1.6	5.9	1.0	0.8	-2.4	-1.1	0.8	-1.1	-0.9
Alcohol drinker status: Never	0.8	0.9	1.1	-1.0	-0.9	1.0	1.0	-1.0	0.7	1.0
Ever smoked	0.1	0.2	0.3	-0.0	-0.1	0.5	0.6	0.3	0.5	0.4
Basal metabolic rate	0.2	1.2	3.2	-0.1	0.3	1.8	0.9	0.2	1.8	1.1
Leg fat percentage (left)	3.9	14.1	23.5	-3.9	-3.6	3.5	2.5	-3.0	4.5	4.8
Arm fat-free mass (left)	0.8	4.1	8.6	-1.4	-1.0	2.8	1.7	-0.8	2.9	2.3
Number of operations (self-reported)	4.5	6.7	12.1	3.4	3.5	-1.6	-1.3	3.3	-1.8	-2.1
Average weekly beer plus cider intake	0.6	0.9	1.5	1.1	1.2	-0.1	-0.1	1.1	-1.0	-1.2
Irritability	1.0	1.6	3.6	-1.6	-1.5	-0.1	1.9	-1.1	0.7	1.1
Risk taking	0.7	1.0	2.0	0.7	0.6	-1.0	-1.1	0.9	-1.1	-1.4
Ever had prostate specific antigen (PSA) test	0.8	0.9	2.4	0.7	0.7	-1.5	-0.9	0.4	-1.2	-0.9
Fractured/broken bones in last 5 years	1.0	1.2	4.0	-1.0	-0.6	0.8	2.0	-0.5	1.2	0.9
Age started oral contraceptive pill	3.0	3.7	6.5	-1.9	-1.9	1.2	0.7	-2.4	2.2	2.5
Diastolic blood pressure, automated reading	0.4	1.2	2.1	1.2	1.3	-1.5	1.1	1.0	0.7	0.5
Ever depressed for a whole week	0.2	0.2	0.7	0.3	0.7	0.2	0.8	0.4	-0.1	-0.3
Unable to work because of sickness or disability	0.2	0.3	0.9	0.2	0.2	0.6	0.4	-0.2	1.0	0.7
Commuting to job workplace: Cycle	0.1	0.1	0.3	0.2	0.1	0.0	0.4	-0.5	0.1	-0.2
Myopia	1.1	1.6	4.5	-1.6	-1.3	-0.2	0.7	-2.1	0.3	1.3
Vascular/heart problems diagnosed by doctor	3.9	10.7	16.1	3.2	3.1	-2.4	-3.7	1.9	-3.9	-4.0
Cholesterol lowering medication	8.1	11.9	22.0	-4.7	-4.7	1.9	1.9	-4.5	2.3	2.6
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	1.9	-0.1	-0.0	1.4	-0.4	0.6	0.2	0.2
Pain experienced in last month	0.4	0.7	1.7	1.1	1.3	0.5	-0.3	1.1	0.5	0.5
Supplements: Calcium	0.2	0.3	0.7	-0.2	-0.2	0.4	0.3	-0.3	0.8	0.8
Basal cell carcinoma (self-reported)	1.1	1.3	2.2	1.4	1.2	-0.0	-0.8	1.1	-1.2	-1.5
Heart attack/myocardial infarction (self-reported)	2.9	3.7	6.2	-2.5	-2.4	1.2	1.3	-1.4	2.1	2.1
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	4.2	-1.7	-2.1	1.2	0.8	-1.7	1.8	1.9
Heart disease (siblings)	3.0	3.7	6.7	-2.6	-2.5	0.9	1.2	-2.0	1.6	1.9
Alcohol drinker status: Previous	4.1	4.6	6.8	-2.6	-2.6	1.9	1.4	-2.1	1.9	2.3
Pack years of smoking	0.6	0.9	2.0	-1.2	-1.4	0.6	0.6	-0.4	1.1	1.0
Impedance of whole body	0.5	2.4	7.7	1.0	0.6	-2.8	-0.9	0.2	-2.0	-1.8
Leg fat mass (left)	2.4	9.3	16.6	-2.8	-2.5	3.1	2.0	-2.2	4.0	4.1
Arm predicted mass (left)	0.7	3.8	7.8	-1.4	-1.0	2.8	1.6	-0.9	2.8	2.2