Hub : Genes

TFPI

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Adipose Visceral Omentum 0.0990 0.0480 0.00700 0.019 NA 0.038 NA 0.025 3.3e-02 NA 4.5e-03 NA 1.8e-02
2 GTEx Cells Transformed fibroblasts 0.0720 0.0320 0.00032 0.043 NA 0.026 NA 0.033 3.6e-04 NA 4.3e-03 NA 1.6e-03
3 GTEx Esophagus Muscularis 0.2880 0.0680 0.00004 0.092 NA 0.097 NA 0.067 3.0e-06 NA 1.7e-06 NA 6.9e-05
4 GTEx Heart Atrial Appendage 0.3240 0.1140 0.00660 0.093 NA 0.037 NA 0.062 5.7e-05 NA 8.9e-03 NA 9.4e-04
5 GTEx Muscle Skeletal 0.1139 0.0423 0.00120 0.079 NA 0.075 NA 0.081 3.8e-08 NA 8.0e-08 NA 2.6e-08
6 GTEx Skin Sun Exposed Lower leg 0.0800 0.0330 0.00085 0.040 NA 0.026 NA 0.028 2.9e-04 NA 3.1e-03 NA 2.2e-03
7 ROSMAP Brain Pre-frontal Cortex 0.0556 0.0240 0.00069 0.005 0.014 0.003 0.015 0.008 6.4e-02 0.0049 1.1e-01 0.0048 3.0e-02
8 TCGA Colon Adenocarcinoma 0.0780 0.0530 0.00510 0.042 0.032 0.023 NA 0.025 1.7e-03 0.0060 1.7e-02 NA 1.3e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8
Bipolar Disorder (2018) 0.2 0.4 1.2 0.4 0.4 -0.2 -0.7 -0.9 -0.0 1.1 -0.2
Bipolar Disorder or Schizophrenia 0.6 1.4 3.6 -1.0 0.6 -0.9 -1.4 -1.9 -1.0 1.6 0.5
Depressed Affect (Nagel 2018) 0.8 1.8 6.5 -2.5 -0.7 -1.0 -0.1 -0.0 -1.1 -2.0 -1.0
Depression (Nagel 2018) 0.2 0.3 1.0 -0.7 -0.0 -0.6 0.0 -0.2 -0.8 -0.5 1.0
Intelligence (Savage-Jansen 2018) 0.2 0.8 1.9 0.0 -1.0 1.1 0.9 0.6 0.2 -0.9 -1.4
Neuroticism (Nagel 2018) 1.1 2.6 8.4 -2.9 -0.7 -2.1 -0.8 -0.6 -1.7 -1.7 -0.7
Schizophrenia (2018) 0.7 1.4 2.9 -1.3 0.4 -1.1 -1.4 -1.7 -1.3 1.1 0.8
Schizophrenia vs Biploar Disorder 0.4 0.5 1.8 -0.1 -0.9 -0.0 -0.4 -0.5 -1.0 -1.3 -0.1
Worry (Nagel 2018) 0.8 1.6 4.6 -2.1 -0.7 -1.8 -0.2 -0.1 -1.6 -1.2 -0.6
Alzheimer’s Disease (in mother) 0.4 0.5 1.9 0.3 -1.4 0.4 0.5 0.3 1.0 -0.4 -0.4
Alzheimer’s Disease (in father) 2.1 2.2 5.3 1.7 0.1 1.2 2.3 1.9 1.8 1.0 0.6
Alzheimer’s Disease (including proxy) 0.9 1.3 4.0 0.2 -2.0 0.7 1.5 1.2 1.2 0.1 -0.9
Crohns Disease (2017) 0.1 0.3 1.0 1.0 -0.5 0.7 0.6 0.3 0.1 -0.4 0.3
Irritable Bowel Disease (IBD) 0.3 0.7 2.4 1.6 0.0 1.0 0.6 0.3 0.1 -0.8 1.1
Ulcerative Colitis (UC) 0.2 0.5 1.3 1.0 0.2 0.7 0.0 -0.2 -0.0 -0.9 1.1
Major Depression (MDD) 0.4 0.5 1.5 -0.1 0.7 -0.8 1.1 1.2 -0.1 -0.5 0.2
Reaction Time 0.2 0.4 0.9 -0.0 -0.0 -1.0 0.3 0.9 0.4 0.6 -0.9
Verbal and Numeric Reasoning (VNR) 0.5 1.3 2.9 0.9 0.2 0.9 1.5 1.4 1.1 -1.7 -0.5
Breast Cancer 1.8 4.4 8.3 -2.9 -1.7 -1.9 -2.5 -2.1 -2.9 -0.5 -1.4
Ovarian Cancer 0.9 1.2 4.9 -0.2 -1.6 0.8 0.7 0.8 0.3 -0.9 -2.2
Prostate Cancer 0.6 0.9 3.0 0.3 1.6 0.1 -0.2 -0.4 0.1 1.2 1.7
Age at First Birth 0.4 0.6 0.9 0.9 0.9 0.1 0.9 0.8 -0.9 -0.4 0.5
Bipolar Disorder (2011) 0.8 0.7 2.0 0.9 0.8 1.0 0.6 0.4 0.7 1.4 -0.6
Body Mass Index (BMI) (2010) 0.9 1.2 2.4 -1.6 -1.3 -1.1 -1.2 -1.4 0.3 -0.7 -0.5
Coronary Artery Disease (CAD) 0.4 0.5 1.7 -0.1 0.1 0.8 -0.6 -1.1 -0.2 1.3 -0.5
Crohns Disease (2012) 0.1 0.2 0.7 0.7 -0.0 0.8 0.1 -0.4 0.2 0.1 0.7
Mean Putamen Volume 0.6 0.6 1.7 -1.2 0.2 -0.7 -1.3 -0.7 -0.8 0.0 0.6
Fasting Glucose 0.9 1.1 4.9 1.6 0.4 0.8 -0.0 0.4 2.2 -0.7 0.3
HbA1C 0.4 0.4 1.3 0.2 -0.9 1.1 -0.1 -0.5 -0.5 -0.0 -0.8
HDL Cholesterol 0.8 1.3 2.4 1.5 1.0 1.0 0.8 0.3 1.2 1.3 1.4
LDL Cholesterol 0.6 1.0 6.1 -0.6 0.6 -0.8 -0.1 -0.2 -2.5 0.4 0.5
Lupus 0.8 1.2 3.1 -0.4 -1.6 0.0 -0.4 -0.0 1.7 -1.8 -0.9
Neuroticism (2016) 2.6 3.7 10.6 -2.9 -0.3 -1.6 -0.8 -0.5 -3.3 -2.7 -0.6
Primary Biliary Cirrhosis 0.8 1.1 4.8 1.1 2.2 0.6 0.9 1.0 0.3 0.5 0.3
Rheumatoid Arthritis 0.3 0.4 1.6 0.6 0.3 1.3 0.4 0.4 0.9 -0.5 0.1
Schizophrenia (2014) 1.3 3.0 9.5 -1.6 -0.6 -1.6 -2.5 -3.1 -1.6 0.2 0.2
Triglycerides 0.7 1.1 4.4 -1.1 -1.3 -0.9 -0.5 0.1 -2.1 0.1 -0.3
Type 2 Diabetes (T2D) (2012) 0.9 1.0 4.0 -0.4 -0.7 0.2 -0.2 0.0 -0.5 -2.0 -1.8
Ulcerative Colitis 0.2 0.3 1.0 1.0 -0.1 1.0 0.3 0.0 0.1 -0.7 0.4
Blood Eosinophil Count 0.9 6.8 28.6 -1.3 -5.3 -0.4 -0.5 -0.1 0.6 -3.3 -3.5
Blood Platelet Count 0.1 1.2 2.6 -0.6 -0.7 -1.6 -1.2 -1.0 1.3 -1.5 0.5
Blood Red Count 0.5 4.6 13.1 -1.7 -3.6 -0.2 -1.2 -1.5 -3.3 -1.6 -2.0
Blood White Count 1.9 14.3 45.3 -4.5 -6.7 -2.2 -2.0 -2.1 -0.9 -2.5 -5.4
Heel T-Score 0.9 7.5 20.7 3.2 4.5 2.0 0.3 -0.4 1.1 3.9 3.0
BMI 1.2 6.8 21.3 -2.0 -4.6 -1.7 -2.8 -3.0 1.7 -2.0 -1.7
Height 0.5 9.2 19.8 3.6 4.5 2.7 3.5 3.0 -2.6 0.7 2.1
Waist Hip Ratio (WHR) 5.3 24.0 69.4 -2.7 -8.3 2.6 1.1 1.6 2.8 -6.1 -7.7
Systolic Blood Pressure 0.5 2.5 5.7 -0.3 -1.5 0.4 2.1 2.4 -1.7 -0.9 -1.8
Smoking Status 0.5 1.2 2.4 -0.2 1.4 1.0 1.6 0.9 0.9 0.8 1.5
Allergy or Eczema 1.7 4.4 15.0 2.2 3.4 -0.6 -0.4 -0.5 0.1 1.8 3.9
Cardiovascular Disease 1.9 6.1 16.8 -2.1 -3.3 0.1 0.8 1.1 -1.2 -3.7 -4.1
Hypothyroidism (self reported) 0.6 1.3 4.6 -2.1 -1.3 -0.8 -0.2 -0.7 -1.6 -0.1 -0.3
Respiratory disease 0.3 0.7 4.0 0.3 -0.9 0.2 -0.1 0.1 -2.0 -0.9 0.1
Type 2 Diabetes (T2D) (2018) 0.8 1.4 3.2 1.2 -1.2 1.4 1.8 1.6 0.7 -0.4 -0.2
Lung FEV1/FVC ratio 1.7 8.6 31.6 -3.5 -3.7 -0.6 -1.8 -1.3 -1.2 -2.3 -5.6
Lung FVC 1.0 5.3 15.4 1.7 3.9 0.6 1.2 0.7 1.1 3.3 3.1
Neuroticism 0.4 1.0 3.6 -1.6 -0.2 -0.5 0.6 0.3 -1.9 -1.0 0.3
Chronotype (morning person) 1.0 2.4 5.8 2.4 1.4 1.2 0.9 0.7 2.1 1.2 1.6
Hair Pigment 0.0 0.9 4.3 -0.4 -0.2 0.7 -0.3 -0.7 -1.3 0.2 -2.1
Tanning 0.1 0.8 1.8 1.1 -0.1 0.8 0.8 0.6 1.3 1.3 0.5
Hand grip strength (left) 1.0 2.7 11.3 1.1 3.4 1.1 0.7 0.1 0.3 1.1 2.4
Number of treatments/medications taken 0.3 0.6 2.0 -0.5 -1.0 0.0 0.6 0.4 -0.8 -0.4 -1.4
Average weekly spirits intake 0.5 0.6 2.9 0.2 -0.2 -0.5 -0.1 0.0 1.7 -0.2 -1.1
Sensitivity / hurt feelings 0.2 0.4 0.9 -0.6 0.1 -0.3 0.9 0.7 0.2 0.8 0.9
Frequency of depressed mood in last 2 weeks 0.2 0.3 1.3 -0.7 -0.8 0.1 0.3 0.1 -1.1 -0.4 0.4
Hearing difficulty/problems: Yes 0.7 1.1 4.0 -2.0 0.4 -1.1 -0.9 -1.0 -1.1 0.7 0.6
Relative age of first facial hair 0.4 0.7 4.1 -0.5 -1.0 0.5 0.2 0.2 -0.4 -0.2 -2.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 2.7 -0.5 1.2 -1.6 0.1 0.6 0.3 -0.3 0.2
Ever used hormone-replacement therapy (HRT) 0.6 0.7 2.1 0.6 0.4 1.3 0.9 0.4 1.5 0.4 0.5
Ever had hysterectomy (womb removed) 2.0 2.2 5.7 2.3 1.5 0.0 0.1 -0.1 1.2 2.4 1.8
Systolic blood pressure, automated reading 0.1 0.4 1.9 -0.2 -0.7 -0.3 0.2 0.4 -1.4 0.2 -0.7
Eye problems/disorders: Diabetes related eye disease 0.5 0.6 1.7 -0.5 -0.8 -0.8 0.2 -0.0 -1.3 0.4 1.1
Angina 0.9 1.2 2.8 -1.7 -1.2 -0.8 0.1 0.5 -0.6 -1.1 -1.6
Medication for hormone replacement therapy 0.9 1.0 4.2 0.1 0.8 -0.2 1.2 1.1 2.1 -0.6 -0.4
Vitamin and mineral supplements 1.1 1.5 3.6 0.9 0.2 0.2 1.6 1.6 1.9 1.4 -0.1
Supplements: Zinc 3.1 3.4 6.2 2.0 -0.3 2.5 2.2 2.4 1.4 -1.6 -1.4
Medication: Co-codamol 0.2 0.2 0.7 0.3 0.8 0.7 0.5 0.3 -0.1 0.1 -0.2
Medication: Metformin 0.2 0.3 1.0 -0.5 -0.7 0.2 -0.3 -0.5 -1.0 0.1 -0.3
Diabetes (father) 0.5 0.6 1.7 0.3 0.7 1.1 0.5 0.3 0.5 -1.3 -1.0
Diabetes (mother) 0.5 0.6 2.2 -0.4 -0.7 0.5 0.2 0.6 0.7 -1.5 -1.0
Severe depression (siblings) 1.1 1.2 3.9 0.4 -0.2 0.8 2.0 1.8 0.0 -0.4 -1.1
Pack years adult smoking proportion 0.2 0.3 0.8 0.4 -0.5 -0.3 0.5 0.9 0.3 -0.2 0.6
Impedance of leg (right) 0.5 2.4 6.1 0.1 0.2 1.5 1.5 1.9 -1.6 -2.5 -1.5
Leg fat-free mass (left) 0.1 0.7 1.6 -0.8 -0.6 -1.1 -1.0 -1.3 0.3 0.6 -0.1
Trunk fat percentage 0.7 3.0 7.6 -1.4 -2.8 -1.0 -1.6 -1.7 1.2 -1.4 -2.0
Hand grip strength (right) 0.9 2.5 5.6 1.6 2.4 1.8 1.7 1.2 -0.0 1.1 1.7
Townsend deprivation index at recruitment 0.5 0.7 2.7 -0.6 -1.4 -0.3 -0.0 0.1 -0.7 0.1 -1.6
Current tobacco smoking 1.0 1.6 6.4 0.4 1.3 -0.1 0.6 0.2 1.3 1.7 2.5
Average weekly fortified wine intake 0.2 0.2 0.3 -0.5 0.1 -0.5 -0.6 -0.5 0.1 -0.4 0.5
Maternal smoking around birth 0.3 0.5 2.0 -0.8 -0.5 -1.4 0.2 0.3 -0.3 0.0 0.8
Fed-up feelings 0.9 1.6 3.2 -0.8 -1.3 1.1 1.7 1.8 -0.7 -1.1 -1.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.9 1.2 3.1 -1.2 0.2 -0.6 -0.7 -1.2 -1.8 0.5 1.4
Relative age voice broke 0.2 0.4 1.2 1.1 0.4 0.8 0.5 0.7 -0.1 0.4 -0.3
Taking other prescription medications 0.3 0.5 1.1 -0.6 -1.1 -0.9 -0.4 -0.8 -0.4 0.2 -0.9
Age when periods started (menarche) 0.7 1.7 6.5 -0.1 2.0 -0.1 0.1 0.0 -2.5 1.7 0.7
Bilateral oophorectomy (both ovaries removed) 2.9 3.4 9.8 1.6 2.4 -0.3 0.0 -0.1 1.9 2.4 3.1
Heel bone mineral density (BMD) T-score, automated (left) 1.4 3.2 11.4 2.2 3.4 1.6 0.8 0.1 1.9 0.9 1.3
Tinnitus: Yes, but not now, but have in the past 0.4 0.5 1.3 0.6 0.4 0.1 0.4 0.3 1.0 1.1 -0.9
Qualifications: CSEs or equivalent 0.6 0.8 1.6 -1.2 -1.2 -0.2 -0.1 0.4 0.3 1.0 -1.3
Serious illness, injury or assault to yourself 0.6 0.7 1.9 -1.2 1.1 -1.0 -0.1 -0.1 -1.4 -0.2 -0.5
High blood pressure 1.4 3.9 11.5 -1.8 -2.8 -0.6 0.6 1.2 0.3 -2.4 -3.4
Hayfever, allergic rhinitis or eczema 1.0 2.2 7.3 1.7 2.4 -0.6 0.5 0.2 1.0 0.5 2.7
Multivitamins +/- minerals 0.8 1.0 2.7 -0.0 0.6 0.2 -0.9 -1.4 -1.4 0.0 1.7
Stomach or abdominal pain in last month 0.3 0.4 1.5 -0.2 0.1 0.5 0.7 0.2 -0.1 -1.2 -0.9
Supplements: Glucosamine 0.8 1.0 3.3 -0.8 -0.1 0.3 1.1 0.8 -1.2 -1.8 -0.7
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.4 0.5 0.7 0.7 0.4 0.8 -1.2 0.5 0.3
Medication: Atenolol 1.8 2.3 4.4 -1.5 -1.6 -2.1 -1.7 -1.5 1.5 -1.2 -0.6
Medication: Levothyroxine sodium 0.9 1.5 3.8 -1.9 -0.9 -1.1 -0.8 -1.3 -1.9 -0.4 0.0
Sitting height 1.6 11.5 31.6 4.1 5.6 2.3 3.5 2.9 -1.0 2.3 3.4
Chronic bronchitis/emphysema (father) 0.7 0.8 3.3 0.8 0.4 0.3 -0.4 -0.5 1.0 0.8 1.8
High blood pressure (mother) 0.7 1.0 3.0 -0.6 0.9 -0.2 0.1 0.0 -1.7 -1.3 -1.6
Body mass index (BMI) 2.0 8.4 20.7 -3.0 -4.5 -2.5 -3.2 -3.2 1.4 -1.8 -2.3
Impedance of leg (left) 0.6 2.7 6.1 0.3 0.3 1.7 1.7 2.0 -1.9 -2.5 -1.3
Leg predicted mass (left) 0.1 0.6 1.5 -0.7 -0.7 -1.1 -1.0 -1.2 0.4 0.6 0.0
Trunk fat mass 0.7 2.9 8.5 -1.4 -2.9 -0.9 -1.3 -1.4 1.0 -1.5 -2.2
Waist circumference 3.4 12.6 36.5 -3.5 -6.0 -1.5 -2.9 -2.7 1.1 -3.5 -4.5
Number of incorrect matches in round 0.3 0.5 1.7 -1.3 -0.1 -1.0 -0.3 -0.4 0.6 0.0 -0.6
Past tobacco smoking 0.3 0.6 1.3 1.2 -0.0 -0.3 -1.0 -1.1 -0.4 0.7 -0.6
Alcohol usually taken with meals 2.9 4.7 8.8 2.8 0.1 3.0 2.6 2.5 2.8 -0.2 0.7
Nervous feelings 0.7 1.2 2.7 -0.6 -0.5 1.2 1.6 1.6 -0.9 -1.0 -0.8
Frequency of tenseness / restlessness in last 2 weeks 0.6 0.9 4.4 0.1 -0.4 1.2 0.3 0.2 -2.1 -0.3 -1.2
Hearing difficulty/problems with background noise 0.2 0.3 1.9 -1.4 -0.2 -0.4 0.2 0.5 -0.2 -0.4 -0.4
Hair/balding pattern: Pattern 2 2.7 3.4 9.2 -2.0 -0.1 -1.2 -2.7 -3.0 -2.0 -0.1 0.8
Had menopause 1.2 1.5 4.2 -0.6 0.3 -0.4 -1.5 -1.6 -0.9 1.2 2.0
Had other major operations 0.5 0.7 2.2 -1.2 -0.8 -1.5 -0.6 -0.7 -0.4 0.4 0.0
Forced vital capacity (FVC) 1.6 6.0 15.2 2.5 3.9 1.8 2.6 2.3 0.3 2.3 2.5
Heel bone mineral density (BMD) T-score, automated (right) 0.9 2.0 8.8 1.7 3.0 1.3 0.4 -0.3 1.2 0.5 1.1
Ever unenthusiastic/disinterested for a whole week 0.8 1.0 3.9 -1.1 -0.8 0.1 0.2 0.1 -1.5 -0.1 -2.0
Qualifications: None of the above 1.8 3.8 13.2 -2.4 0.2 -3.6 -2.1 -1.6 -1.4 -0.7 1.5
Financial difficulties in last 2 years 0.7 0.9 4.9 -0.3 0.3 -0.4 0.5 0.5 -2.2 1.0 -0.5
Mouth/teeth dental problems 0.3 0.4 1.3 1.1 -0.1 0.9 0.5 0.3 1.0 -0.0 -0.5
Heart attack 1.1 1.4 5.1 -1.5 -2.3 -0.8 -0.7 -0.6 -1.0 -0.9 -0.7
Allergy 0.6 1.3 5.7 -0.7 -1.1 1.3 0.3 0.7 0.9 -0.0 -2.4
Pain all over the body in last month 1.5 1.6 3.9 -1.7 0.8 -2.0 -1.3 -1.2 -0.6 1.1 0.7
Diabetes (self-reported) 0.2 0.2 1.2 0.3 -0.4 0.2 0.2 0.0 -1.1 0.5 -0.0
Hayfever/allergic rhinitis (self-reported) 1.3 1.7 4.8 2.2 1.0 1.1 0.8 0.4 1.0 1.3 1.7
Medication: Ramipril 1.8 2.3 5.0 -1.4 -1.9 0.5 1.6 1.9 -1.2 -0.7 -2.2
Medication: Simvastatin 1.6 2.4 9.2 -0.6 -2.1 0.4 0.5 0.5 -2.0 -0.5 -3.0
Fluid intelligence score 1.0 2.0 5.9 -0.3 -0.8 1.0 1.8 1.8 0.6 -2.4 -1.3
Illnesses of siblings 0.7 0.9 4.4 0.5 -0.6 0.7 1.2 0.6 0.5 2.1 0.3
Neuroticism score 0.4 0.9 1.8 -1.1 -0.5 0.3 1.4 1.0 -1.3 -1.1 -0.3
Weight 0.6 3.2 8.1 -1.9 -2.8 -1.4 -1.7 -1.8 0.3 -1.5 -1.8
Impedance of arm (right) 1.5 6.9 19.7 2.9 4.4 2.1 2.6 2.0 -0.0 2.4 2.3
Arm fat percentage (right) 0.9 3.6 9.2 -1.6 -3.0 -1.4 -1.9 -2.1 1.7 -1.0 -1.8
Trunk fat-free mass 0.1 0.7 2.0 -0.9 -1.4 -0.7 0.0 0.2 -0.4 -1.3 -1.0
Hip circumference 0.7 2.9 6.8 -1.6 -1.4 -1.9 -2.6 -2.6 -0.5 -0.8 -0.8
Time employed in main current job 0.4 0.4 1.4 0.2 1.0 -1.2 -0.1 -0.1 -0.6 0.3 0.6
Alcohol intake versus 10 years previously 2.4 3.7 9.3 -3.0 -2.1 -2.4 -2.1 -2.2 -0.5 -0.2 -0.4
Father’s age at death 0.8 1.1 3.7 1.4 1.9 -0.3 -0.3 0.1 0.2 -0.0 1.7
Worrier / anxious feelings 0.6 1.1 3.5 -0.2 0.1 -0.0 1.8 1.9 -1.2 -0.1 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.2 0.4 1.7 -0.3 0.3 0.7 0.7 0.5 -1.3 -0.0 -0.2
Falls in the last year 0.4 0.5 1.6 0.1 -0.2 -0.7 0.9 0.9 -0.2 1.3 0.3
Hair/balding pattern: Pattern 3 0.7 1.1 3.0 0.5 0.7 0.1 1.3 1.6 0.3 -0.8 -1.7
Number of live births 0.5 0.7 2.1 -0.4 -1.4 0.2 -0.6 -1.1 -0.9 0.6 0.1
Forced expiratory volume in 1-second (FEV1) 0.9 3.1 9.2 1.8 3.0 1.8 1.6 1.4 0.3 1.9 1.1
Pulse rate 0.9 1.6 7.3 0.7 2.7 -0.7 -0.4 -0.2 0.5 2.0 0.0
Happiness 1.5 1.8 6.6 -0.8 -0.3 -0.1 0.5 0.7 -2.6 -2.5 -0.3
Noisy workplace 1.4 1.8 8.9 -0.5 3.0 -1.0 -0.7 -0.7 -0.3 1.1 1.3
Qualifications: A levels/AS levels or equivalent 0.6 1.3 3.1 1.2 1.5 1.6 0.2 -0.3 -0.4 1.8 0.8
Serious illness, injury or assault of a close relative in last 2 years 0.3 0.3 1.4 -0.4 1.2 -0.7 0.4 0.3 -0.6 0.3 -0.2
Mouth/teeth dental problems: Dentures 0.6 1.0 4.0 -1.1 -0.0 -2.0 0.7 1.1 -0.6 -0.2 0.9
Asthma 0.3 0.6 2.4 0.8 -0.5 0.2 0.9 0.6 -1.6 -0.3 -0.4
Medication: Ibuprofen (e.g. Nurofen) 1.2 1.5 4.3 -1.6 0.3 -0.8 -1.9 -2.1 -0.7 0.2 0.6
Medication: Cholesterol lowering 1.5 2.4 4.8 -0.1 -2.0 0.6 2.0 2.2 -1.2 -0.6 -2.1
Depression (self-reported) 0.8 1.0 4.2 0.5 -0.8 0.6 0.7 0.7 -2.0 -0.0 -1.2
Medication: Lansoprazole 1.1 1.3 2.9 -1.7 -0.1 -1.7 -1.2 -1.2 -0.8 -0.5 0.7
Prospective memory result 0.6 0.7 1.6 -0.3 0.0 -0.6 -1.3 -1.1 0.3 1.2 0.9
Lung cancer (father) 0.8 0.9 2.2 -1.5 1.1 -1.4 -0.5 -0.1 -1.2 0.1 0.0
Illnesses of mother 1.2 1.5 4.9 1.3 0.6 0.5 0.6 0.8 2.2 1.5 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.3 1.0 3.0 0.9 1.7 1.3 0.9 0.6 0.3 1.1 0.6
Pulse wave Arterial Stiffness index 1.8 2.1 5.6 -1.7 -2.4 -1.5 -0.7 -0.1 -0.5 -1.5 -1.6
Impedance of arm (left) 1.5 7.0 18.7 3.3 4.3 2.3 2.3 1.8 -0.1 2.5 2.5
Arm fat mass (right) 1.0 4.3 11.0 -2.0 -3.3 -1.7 -2.2 -2.2 1.2 -1.6 -1.9
Trunk predicted mass 0.1 0.7 2.0 -0.9 -1.4 -0.8 -0.0 0.1 -0.4 -1.2 -0.8
Standing height 0.5 5.1 10.4 2.0 3.2 2.1 2.9 2.7 -2.4 0.4 0.8
Length of working week for main job 0.8 0.9 2.0 0.7 1.2 0.6 1.0 1.0 0.0 1.4 1.0
Exposure to tobacco smoke at home 0.1 0.1 0.3 0.3 -0.4 -0.1 0.5 0.2 0.2 -0.4 -0.5
Breastfed as a baby 1.1 1.4 3.1 -0.1 -0.3 1.0 1.5 1.8 -1.4 -1.6 -0.4
Tense / ‘highly strung’ 0.2 0.4 2.1 -0.6 -0.5 -0.0 -0.1 -0.3 -1.4 0.4 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 2.7 0.1 0.3 -0.3 -0.2 -0.2 -1.6 -0.1 -0.1
Hair/balding pattern: Pattern 4 0.1 0.4 0.9 0.0 0.4 -0.3 -0.9 -0.8 0.5 0.7 -0.4
Birth weight of first child 2.0 3.7 7.4 2.7 1.8 2.5 2.0 1.4 1.0 2.0 1.2
Peak expiratory flow (PEF) 0.2 0.5 1.8 0.7 -0.1 1.3 0.8 0.5 -0.0 -0.7 0.3
Pulse wave reflection index 1.1 1.4 5.5 -1.3 -2.3 -0.2 0.0 0.2 0.3 -1.6 -1.1
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.7 -1.6 -1.0 -0.7 0.1 -0.1 -0.1 0.1 -1.2
Loud music exposure frequency 1.0 1.1 3.2 0.6 0.6 0.1 1.3 1.4 1.8 0.4 0.7
Qualifications: O levels/GCSEs or equivalent 1.0 1.5 4.8 1.9 1.0 2.2 1.0 0.6 1.0 -0.6 0.4
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.0 -1.0 -0.6 -0.3 0.4 0.2 0.9 -0.3 -0.0
Blood clot in the leg (DVT) 1.1 1.4 6.0 -0.8 -2.4 -1.2 -1.0 -0.8 -0.4 -1.2 0.3
Medication: Paracetamol 0.6 1.0 3.3 -0.3 1.8 -1.8 -0.4 -0.1 -0.3 0.8 0.8
Headache pain in last month 0.6 1.0 2.8 -0.7 1.4 -0.1 -0.8 -1.0 -1.7 0.5 0.9
Medication for cholesterol, blood pressure or diabetes 1.8 2.9 7.0 -0.3 1.5 -1.2 -2.6 -2.7 0.6 1.1 2.1
Glaucoma (self-reported) 3.2 3.7 5.6 1.3 -1.3 2.4 1.9 2.2 1.9 -2.3 -1.8
Gout (self-reported) 0.7 0.9 3.0 -0.0 -0.1 -0.0 -0.7 -1.1 -1.7 -1.3 -0.9
Hypothyroidism/myxoedema (self-reported) 0.5 0.9 2.1 -1.2 -1.5 -0.2 0.4 0.2 -1.2 -0.5 -1.2
Medication: Amlodipine 0.6 0.9 4.6 -0.7 -0.8 -0.6 -0.0 0.2 0.7 -0.6 -2.2
Medication: Ventolin 100micrograms inhaler 0.4 0.5 2.4 -0.5 -1.5 -0.6 0.2 -0.0 -0.6 0.5 0.3
Birth weight 0.9 1.9 5.7 1.7 1.6 0.6 0.1 -0.3 0.4 2.4 1.8
Chronic bronchitis/emphysema (mother) 1.3 1.6 8.0 -1.4 -0.4 -2.8 -0.8 -0.2 -0.9 -1.0 0.0
High blood pressure (siblings) 0.4 0.6 1.4 -0.2 0.9 -0.2 -1.1 -0.7 -0.3 -1.2 -0.8
Forced vital capacity (FVC), Best measure 1.3 4.6 12.5 2.2 3.5 1.9 2.1 1.5 0.2 2.1 2.1
Body fat percentage 1.1 4.4 13.1 -1.7 -3.6 -1.0 -1.7 -1.8 1.4 -1.9 -2.5
Leg fat percentage (right) 2.5 9.1 27.2 -3.1 -5.2 -1.8 -2.1 -1.9 1.1 -3.3 -3.6
Arm fat-free mass (right) 0.4 1.9 4.3 -1.6 -2.1 -1.3 -1.1 -1.0 -0.7 -1.7 -1.2
Exposure to tobacco smoke outside home 0.6 0.8 2.2 0.9 -0.2 0.7 1.5 1.0 0.9 0.6 0.8
Comparative body size at age 10 2.3 6.3 19.4 -2.4 -3.9 -0.3 -1.0 -0.8 -1.0 -2.6 -4.4
Number of full brothers 2.9 3.7 8.3 -2.3 -0.8 -2.2 -2.9 -2.8 -1.5 0.3 0.0
Worry too long after embarrassment 0.4 0.6 2.4 -0.5 -0.7 0.5 0.7 0.5 -1.6 -0.1 -0.9
Seen a psychiatrist for nerves, anxiety, tension or depression 0.8 1.0 3.4 -0.5 -0.7 0.3 -0.4 -0.2 -1.7 -0.8 -1.9
Wheeze or whistling in the chest in last year 0.8 1.3 4.7 -0.5 -2.2 -0.2 0.7 1.0 0.0 -0.8 -1.9
Number of children fathered 1.2 1.4 4.1 -1.3 -2.0 -0.9 -0.6 -0.4 0.0 -1.3 -1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.8 1.0 1.8 -1.0 -0.7 -0.9 -1.4 -1.3 -0.5 -1.2 -0.6
Age at first live birth 0.3 0.5 1.1 0.7 0.0 0.7 0.9 0.9 -0.5 0.3 -1.0
Pulse wave peak to peak time 1.8 2.1 6.1 1.8 2.5 1.5 0.8 0.2 0.3 1.4 1.7
Health satisfaction 2.5 3.3 9.4 -1.7 -1.2 -1.1 -0.8 -0.3 -2.6 -3.1 -2.0
Shortness of breath walking on level ground 1.6 1.9 4.7 -1.4 -1.4 -2.2 -0.9 -0.3 -0.8 -2.0 -1.0
Qualifications: College or University degree 1.1 3.4 12.3 2.5 0.4 3.5 2.2 1.3 0.1 1.2 0.6
Eye problems/disorders: None of the above 0.5 0.6 1.1 -1.0 -0.2 -0.7 -1.0 -0.7 -1.1 0.5 -0.1
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.8 0.3 0.1 0.9 0.4 0.2 -0.4 0.4 -0.6
Emphysema/chronic bronchitis 2.2 2.5 5.1 -2.1 0.4 -2.2 -2.2 -2.0 -0.9 -1.1 -0.3
Medication for pain relief, constipation, heartburn 0.5 0.8 2.3 0.5 -0.8 1.0 0.6 0.9 0.5 -1.5 -1.0
Neck or shoulder pain in last month 0.3 0.5 1.4 -0.7 -0.3 0.7 0.4 0.0 0.2 1.2 -1.0
Medication: Blood pressure 1.3 2.3 7.8 -0.3 -1.6 0.4 1.5 1.7 -0.2 -1.4 -2.8
Angina (self-reported) 0.6 0.8 2.4 -1.5 -0.9 -0.9 0.3 0.6 -0.4 -0.9 -1.1
Migraine (self-reported) 0.9 1.1 4.3 1.3 2.1 -0.6 -0.5 -0.2 -0.6 1.3 -0.4
Medication: Ibuprofen 0.5 0.6 1.6 -0.9 0.9 -0.1 -0.8 -1.3 -0.1 1.0 0.5
Medication: Allopurinol 2.2 2.9 6.6 -1.5 -1.6 -0.0 -0.9 -1.2 -2.0 -2.3 -2.6
Medication: Omeprazole 2.3 2.7 4.2 -1.3 -2.1 -1.2 -1.8 -2.0 1.9 -1.4 -1.3
Medication: Seretide 50 evohaler 0.9 1.0 3.0 1.3 1.4 0.2 0.4 0.2 0.8 1.7 0.9
Mean time to correctly identify matches 0.2 0.3 1.7 0.4 0.1 -0.8 0.1 0.4 -0.0 1.3 -0.1
Heart disease (mother) 0.9 1.1 2.6 -0.1 1.2 1.0 -0.5 -0.9 -1.5 -0.4 -1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.8 4.1 1.6 0.1 0.6 1.9 1.7 2.0 0.7 0.0
Whole body fat mass 1.0 4.3 13.4 -1.7 -3.7 -0.9 -1.6 -1.6 1.2 -1.9 -2.6
Leg fat mass (right) 1.7 6.6 20.9 -2.6 -4.6 -1.6 -2.0 -2.0 0.9 -2.4 -2.9
Arm predicted mass (right) 0.4 2.3 4.9 -1.6 -2.2 -1.1 -1.1 -1.0 -0.7 -2.2 -1.4
Pulse rate, automated reading 5.1 16.5 59.3 3.6 7.7 0.4 0.9 0.5 2.3 5.0 5.3
Alcohol intake frequency. 2.4 5.7 17.4 -2.3 -4.2 -2.0 -0.7 -0.3 1.4 -2.1 -3.5
Comparative height size at age 10 0.2 1.3 2.1 1.4 1.1 0.9 1.4 1.4 -0.7 0.7 1.4
Number of full sisters 0.9 1.1 3.0 -0.5 0.2 -1.6 -1.7 -1.4 -0.7 -0.8 0.2
Suffer from ‘nerves’ 0.8 1.3 7.5 -0.4 0.8 0.3 0.5 0.5 -2.7 -1.0 -0.5
Overall health rating 0.7 1.6 3.1 -1.6 -0.1 -1.7 0.2 0.7 -1.8 -1.6 -0.8
Chest pain or discomfort 0.3 0.5 1.7 -0.8 -0.2 -1.3 -0.1 -0.1 0.2 -1.1 0.0
Had major operations 0.9 1.1 1.7 0.6 -1.3 1.2 1.3 0.9 1.0 -0.5 -1.2
Age at last live birth 0.7 1.0 3.6 0.7 -0.6 1.4 0.6 0.5 -0.9 0.0 -1.9
Family relationship satisfaction 1.0 1.2 2.4 -0.9 -0.9 -0.5 0.5 1.0 -1.4 -1.4 -1.6
Leg pain on walking 0.9 1.1 2.6 -1.1 0.0 -1.5 -1.1 -0.7 -0.1 -1.6 -0.8
Qualifications: NVQ or HND or HNC or equivalent 0.8 1.0 2.2 -1.1 -0.4 -1.5 -0.7 -0.7 -1.0 -0.8 -1.3
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.8 0.6 0.4 -0.3 0.5 0.3 0.4 0.5 0.9
Illness, injury, bereavement, stress in last 2 years 0.4 0.5 1.8 0.3 -0.3 1.3 0.9 0.7 0.6 -0.6 -0.5
Medication: Aspirin 0.5 0.7 2.7 -0.6 -0.9 -0.5 0.4 0.2 -1.6 1.1 -0.2
Supplements: Vitamin C 0.2 0.3 1.4 -0.1 -0.7 0.0 -0.2 -0.0 0.2 -1.2 0.5
Knee pain experienced in last month 1.7 2.6 8.0 -1.1 0.7 -1.2 -2.7 -2.8 -1.0 0.3 0.8
Hypertension (Self-reported) 1.7 4.8 15.1 -2.3 -3.2 -0.7 0.5 1.1 0.1 -2.4 -3.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.6 0.7 1.1 -1.0 -1.0 -0.7 -0.8 -0.9 0.7 -0.5 -1.0
Illnesses of father: Heart disease 2.1 2.9 5.3 -2.3 -1.8 -2.0 -2.3 -1.9 0.3 -1.1 -0.5
Illnesses of siblings: Diabetes 1.3 1.5 9.8 -0.8 -0.6 -0.2 0.0 0.0 1.0 -3.1 -0.8
Smoking status: Previous 0.9 1.4 4.9 -2.0 -0.7 -0.7 0.0 0.4 -0.5 -2.2 -0.7
Forced expiratory volume in 1-second (FEV1), predicted 0.5 1.0 2.9 0.6 1.7 1.2 1.0 0.9 -0.8 0.8 -0.2
Whole body fat-free mass 0.1 0.6 1.1 -0.9 -1.1 -1.0 -0.7 -0.7 -0.2 -0.6 -0.6
Leg fat-free mass (right) 0.1 0.5 1.2 -0.5 -0.2 -0.9 -0.8 -1.1 0.1 0.8 0.3
Arm fat percentage (left) 0.9 3.5 9.1 -1.3 -3.0 -1.2 -2.0 -2.1 2.0 -0.9 -1.7
Average weekly red wine intake 0.5 0.8 2.9 0.5 1.1 0.2 0.9 0.8 0.6 0.0 1.7
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.3 0.5 -0.4 1.1 0.6 0.2 1.1 -0.5 -0.5
Mood swings 0.3 0.6 2.2 -1.1 -0.1 -0.3 0.5 0.2 -1.0 -1.5 -0.1
Loneliness, isolation 1.0 1.4 4.3 -2.1 -0.3 -0.8 -0.7 -0.5 -1.9 -0.6 -1.0
Long-standing illness, disability or infirmity 0.2 0.3 0.9 -0.1 0.9 -0.9 0.5 0.5 -0.2 0.6 -0.2
Ever had bowel cancer screening 2.6 3.0 10.1 -1.4 -3.2 -0.4 -1.7 -1.8 0.7 -1.0 -2.0
Diabetes diagnosed by doctor 0.1 0.2 0.4 0.5 -0.2 -0.2 -0.5 -0.5 -0.6 0.4 0.5
Ever had stillbirth, spontaneous miscarriage or termination 2.1 2.2 4.3 -1.3 1.0 -1.2 -1.6 -2.1 -1.7 0.8 1.8
Friendships satisfaction 0.4 0.5 1.4 -0.2 -0.5 0.2 1.2 1.1 -0.4 -0.1 -0.8
Qualifications: nursing, teaching 0.8 1.3 4.5 1.4 -0.1 2.1 0.4 0.1 1.1 -1.4 -0.6
Commuting to job workplace: Walk 0.8 0.8 4.2 -0.5 -0.3 0.2 -0.6 -0.6 -2.0 -1.2 0.1
Eye problems/disorders: Cataract 0.5 0.6 1.8 -0.3 1.4 -1.0 0.3 0.3 -1.1 0.3 0.1
Mouth/teeth dental problems: Mouth ulcers 1.7 2.8 7.8 2.7 1.5 2.8 1.2 1.2 0.4 1.3 -0.5
Medication for cholesterol 1.5 2.3 6.7 1.6 1.8 -0.3 -0.2 -0.4 -0.9 2.2 2.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.4 0.1 -0.4 0.3 -0.0 -0.0 0.6 -0.3 0.6
Back pain experienced in last month 0.8 1.1 3.0 0.4 1.4 -0.3 1.5 1.7 1.0 -0.6 -0.4
Mineral and other dietary supplements 0.4 0.6 2.4 0.4 -0.0 -0.1 0.6 1.0 0.8 1.5 -0.2
Breast cancer (self-reported) 2.8 3.4 14.3 0.5 2.3 -0.2 1.1 0.8 0.6 3.8 2.2
Asthma (self-reported) 0.3 0.6 2.5 0.7 -0.3 0.1 1.0 0.7 -1.6 -0.2 -0.5
Osteoporosis (self-reported) 0.9 1.2 3.8 -1.1 -1.5 -2.0 -0.7 -0.0 0.1 0.1 -1.1
Osteoarthritis (self-reported) 1.1 1.4 6.4 -1.3 -0.8 -1.0 -0.6 -0.9 2.5 -0.5 0.2
Medication: Aspirin 0.7 0.9 3.2 -1.0 -1.2 -0.7 0.3 0.0 -1.8 1.1 -0.4
Medication: Gliclazide 0.5 0.6 1.9 -0.5 -1.1 -1.4 -0.6 -0.4 -0.6 0.0 0.4
Illnesses of father: None of the above (group 1) 0.4 0.5 1.5 0.9 0.1 0.8 0.8 0.3 0.3 1.2 -0.2
Smoking status: Current 1.3 2.0 6.7 0.8 1.4 0.4 1.0 0.5 1.4 1.8 2.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.1 2.3 4.9 2.1 1.6 1.3 0.8 0.4 2.2 1.7 0.9
Whole body water mass 0.1 0.6 1.2 -0.9 -1.1 -1.1 -0.7 -0.7 -0.2 -0.6 -0.5
Leg predicted mass (right) 0.1 0.5 1.3 -0.5 -0.2 -0.9 -0.8 -1.1 0.0 0.8 0.4
Arm fat mass (left) 1.0 4.0 11.2 -1.7 -3.4 -1.3 -2.1 -2.2 1.2 -1.4 -1.9
Number of self-reported non-cancer illnesses 1.0 1.7 6.7 -0.7 -1.6 -1.1 0.0 -0.0 -1.1 -1.3 -2.6
Average weekly champagne plus white wine intake 0.4 0.5 1.5 -0.5 -0.3 -0.8 -1.0 -1.2 0.4 -0.6 0.5
Miserableness 0.3 0.6 1.4 -0.3 -0.5 0.8 1.1 1.2 -0.1 -0.9 0.1
Guilty feelings 0.5 0.8 3.2 -0.1 1.0 -0.5 -0.1 -0.2 -1.3 0.5 1.8
Wears glasses or contact lenses 0.8 0.9 3.8 0.2 1.5 0.9 0.7 0.2 -1.9 -0.2 0.6
Ever taken oral contraceptive pill 0.6 0.7 2.1 0.7 0.8 1.4 0.3 0.2 1.2 0.3 0.4
Hearing aid user 0.7 0.8 2.0 -0.8 0.2 -1.4 0.7 1.4 -0.6 -0.8 0.9
Mother’s age at death 0.6 0.8 2.1 -0.0 0.3 -1.1 -1.3 -0.6 1.5 -0.3 0.7
Financial situation satisfaction 2.2 2.7 11.2 -1.6 -1.2 -0.4 -0.1 -0.1 -3.3 -1.3 -2.2
Tinnitus: Yes, now most or all of the time 0.9 1.0 2.8 -0.5 -0.9 -0.7 -1.5 -1.7 -0.3 -0.1 1.3
Commuting to job workplace: Public transport 0.7 0.8 1.5 -1.2 -1.2 0.2 -1.1 -1.0 0.0 -0.0 -1.2
Eye problems/disorders: Glaucoma 3.7 4.4 6.6 1.8 -1.4 2.5 2.3 2.5 2.6 -1.7 -1.6
Medication: Blood pressure 1.6 3.0 6.3 -2.5 -2.1 -0.8 -0.4 0.2 0.7 -2.5 -2.5
Pain type(s) experienced in last month: Hip pain 0.7 0.8 1.6 -0.8 1.1 -1.3 -1.0 -0.8 -0.7 0.9 0.4
Supplements: Fish oil (including cod liver oil) 0.9 1.2 3.6 -0.4 -0.6 0.1 -1.6 -1.9 -0.1 -1.7 -0.3
High cholesterol (Self-reported) 1.2 2.1 9.2 -0.9 -2.1 0.7 0.5 0.8 -1.2 -0.1 -3.0
Medication: Bendroflumethiazide 1.7 2.5 7.9 -1.5 -1.6 -0.3 -0.1 -0.3 1.1 -2.8 -2.5
Medication: Paracetamol 0.5 0.8 2.5 -0.0 1.6 -1.2 0.5 0.8 -0.3 0.9 1.0
Medication: Lisinopril 1.6 2.1 10.8 -0.6 -1.3 0.3 0.4 0.5 -0.2 -1.9 -3.3
Medication: Atorvastatin 0.8 1.0 3.2 -1.3 -1.8 -0.3 -0.6 -0.3 -1.1 -0.2 -1.3
Illnesses of father: High blood pressure 0.7 0.9 2.1 0.5 1.5 0.1 0.7 0.4 -0.8 1.3 1.4
Alcohol drinker status: Never 0.6 0.7 2.4 0.0 -1.0 -0.2 1.1 0.8 0.5 -0.2 -1.6
Ever smoked 0.2 0.4 0.9 -0.7 0.1 0.7 1.0 0.9 0.3 -0.1 0.5
Basal metabolic rate 0.2 1.0 2.4 -1.2 -1.6 -1.1 -0.9 -0.9 -0.0 -0.9 -0.8
Leg fat percentage (left) 2.4 8.8 26.4 -2.9 -5.1 -1.7 -2.1 -1.9 1.1 -3.3 -3.5
Arm fat-free mass (left) 0.6 3.0 6.5 -2.1 -2.6 -1.4 -1.3 -1.2 -0.4 -2.3 -1.6
Number of operations (self-reported) 0.9 1.4 4.0 0.8 1.6 -0.1 -0.5 -1.1 0.2 1.6 2.0
Average weekly beer plus cider intake 1.2 1.7 4.5 -0.4 1.5 -1.4 -1.5 -1.3 0.1 2.1 0.6
Irritability 0.5 0.8 2.2 -1.0 -0.3 -1.1 0.5 0.4 -1.5 -1.1 -0.2
Risk taking 0.7 1.1 2.5 1.0 1.4 0.2 0.1 -0.3 -1.3 1.6 1.1
Ever had prostate specific antigen (PSA) test 0.2 0.3 1.1 0.1 1.1 -0.1 -0.4 -0.2 0.4 -0.2 0.8
Fractured/broken bones in last 5 years 0.8 1.0 2.3 -1.4 -0.7 -1.4 -0.3 -0.5 -1.5 0.3 -1.0
Age started oral contraceptive pill 1.9 2.4 6.6 -1.1 -2.6 -0.5 -0.9 -0.8 -0.7 -2.2 -2.0
Diastolic blood pressure, automated reading 0.2 0.7 3.8 -0.6 0.2 -0.5 -0.7 -0.9 -2.0 -0.1 -0.2
Ever depressed for a whole week 0.3 0.4 1.5 -0.6 1.2 0.0 0.7 0.2 -0.7 0.4 -0.6
Unable to work because of sickness or disability 0.3 0.4 1.1 -0.5 -0.1 -0.5 -1.0 -0.8 -0.5 0.6 -0.6
Commuting to job workplace: Cycle 0.2 0.3 0.8 0.9 0.6 0.8 -0.2 -0.3 -0.3 0.2 0.4
Myopia 1.3 1.8 5.0 -1.6 -1.2 -0.6 -0.9 -0.4 -2.2 -1.6 -1.3
Vascular/heart problems diagnosed by doctor 1.4 3.9 11.2 2.3 3.0 1.1 -0.0 -0.6 0.3 2.1 3.4
Cholesterol lowering medication 3.2 4.8 8.9 -2.6 -2.2 -1.8 -2.6 -2.0 -1.3 -1.2 -3.0
Medication: Omeprazole (e.g. Zanprol) 1.5 1.9 5.8 -0.8 -0.5 -1.8 -1.5 -1.6 2.4 -0.3 -0.6
Pain experienced in last month 0.3 0.6 3.4 0.5 -1.8 0.2 0.0 -0.1 0.7 -0.2 0.5
Supplements: Calcium 0.4 0.4 1.1 -0.4 -1.1 -0.9 0.1 0.3 0.4 -0.8 -0.6
Basal cell carcinoma (self-reported) 0.4 0.4 1.3 1.1 0.8 0.1 0.4 0.4 0.8 0.2 0.8
Heart attack/myocardial infarction (self-reported) 1.3 1.7 5.7 -1.5 -2.4 -0.8 -0.6 -0.6 -1.2 -1.3 -1.0
Deep venous thrombosis (DVT) (self-reported) 1.7 2.2 7.3 -1.5 -2.7 -1.6 -1.3 -1.1 -0.9 -1.4 0.3
Heart disease (siblings) 1.1 1.4 4.3 -1.3 -1.2 -0.4 -0.7 -0.1 -0.3 -2.1 -1.8
Alcohol drinker status: Previous 1.9 2.2 6.9 -1.6 -2.6 -1.2 -0.8 -0.3 1.2 -1.2 -1.7
Pack years of smoking 0.2 0.4 1.1 0.2 -0.8 -0.6 0.7 1.0 0.3 -0.3 0.5
Impedance of whole body 0.7 3.7 8.1 2.2 2.9 2.3 2.4 2.2 -0.8 0.4 0.9
Leg fat mass (left) 1.7 6.6 20.6 -2.5 -4.5 -1.4 -2.0 -2.0 0.8 -2.5 -2.9
Arm predicted mass (left) 0.5 2.6 5.7 -2.0 -2.4 -1.4 -1.1 -0.9 -0.4 -2.2 -1.5