Best TWAS P=3.53e-10 · Best GWAS P=4.47e-11 conditioned to 2.84e-11
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RP11-548H3.1 | 0.07 | 0.01 | lasso | 7 | 0.01 | 4.0e-02 | 4.5 | -6.3 | 3.5e-10 | 0.01 | 0.06 | 0.50 | TRUE |
| 2 | GTEx | Adrenal Gland | PNKD | 0.20 | 0.16 | lasso | 5 | 0.19 | 1.6e-07 | 5.2 | -5.3 | 1.1e-07 | 0.01 | 0.03 | 0.96 | FALSE |
| 3 | GTEx | Artery Coronary | RP11-378A13.1 | 0.34 | 0.36 | lasso | 8 | 0.38 | 1.2e-13 | 5.0 | -5.3 | 1.4e-07 | 0.02 | 0.05 | 0.95 | FALSE |
| 4 | GTEx | Brain Cerebellar Hemisphere | RP11-378A13.1 | 0.53 | 0.57 | enet | 24 | 0.60 | 3.3e-19 | 4.6 | -5.1 | 3.1e-07 | 0.01 | 0.12 | 0.87 | FALSE |
| 5 | GTEx | Brain Hypothalamus | RP11-378A13.1 | 0.37 | 0.44 | enet | 17 | 0.45 | 5.6e-12 | 4.6 | -5.2 | 1.9e-07 | 0.00 | 0.04 | 0.96 | FALSE |
| 6 | GTEx | Heart Atrial Appendage | TMBIM1 | 0.11 | 0.09 | lasso | 2 | 0.08 | 1.8e-04 | 4.9 | -5.3 | 1.1e-07 | 0.01 | 0.02 | 0.97 | FALSE |
| 7 | GTEx | Lung | PNKD | 0.13 | 0.04 | enet | 10 | 0.03 | 3.7e-03 | 5.6 | -5.2 | 1.9e-07 | 0.03 | 0.02 | 0.98 | FALSE |
| 8 | GTEx | Skin Not Sun Exposed Suprapubic | PNKD | 0.28 | 0.28 | enet | 9 | 0.26 | 9.7e-15 | 5.3 | -5.3 | 1.0e-07 | 0.01 | 0.02 | 0.98 | FALSE |
| 9 | GTEx | Skin Not Sun Exposed Suprapubic | RP11-378A13.1 | 0.26 | 0.25 | lasso | 8 | 0.28 | 5.6e-16 | 5.2 | -5.2 | 1.5e-07 | 0.01 | 0.06 | 0.93 | FALSE |
| 10 | GTEx | Skin Sun Exposed Lower leg | PNKD | 0.27 | 0.29 | lasso | 8 | 0.34 | 3.9e-29 | 5.2 | -5.4 | 6.5e-08 | 0.01 | 0.02 | 0.98 | FALSE |
| 11 | GTEx | Spleen | RP11-378A13.1 | 0.37 | 0.41 | enet | 27 | 0.41 | 1.2e-11 | 4.9 | -5.7 | 9.6e-09 | 0.01 | 0.05 | 0.95 | FALSE |
| 12 | GTEx | Stomach | RP11-378A13.1 | 0.32 | 0.32 | enet | 20 | 0.34 | 3.4e-17 | 4.6 | -5.3 | 9.0e-08 | 0.01 | 0.17 | 0.82 | FALSE |
| 13 | GTEx | Testis | TMBIM1 | 0.27 | 0.13 | enet | 20 | 0.15 | 2.7e-07 | 5.3 | -5.7 | 1.5e-08 | 0.00 | 0.03 | 0.96 | FALSE |
| 14 | GTEx | Thyroid | PNKD | 0.13 | 0.12 | enet | 13 | 0.14 | 6.3e-11 | 5.5 | -5.5 | 4.4e-08 | 0.01 | 0.01 | 0.99 | FALSE |
| 15 | GTEx | Thyroid | SLC23A3 | 0.11 | 0.04 | lasso | 7 | 0.03 | 3.8e-03 | -4.9 | -5.2 | 1.9e-07 | 0.00 | 0.02 | 0.91 | FALSE |
| 16 | GTEx | Whole Blood | RP11-378A13.1 | 0.11 | 0.13 | enet | 18 | 0.15 | 1.6e-13 | 4.9 | -5.3 | 1.5e-07 | 0.00 | 0.08 | 0.91 | FALSE |
| 17 | METSIM | Adipose | ARPC2 | 0.03 | 0.02 | blup | 458 | 0.01 | 2.2e-03 | 4.1 | -5.3 | 9.9e-08 | -0.01 | 0.03 | 0.96 | FALSE |
| 18 | METSIM | Adipose | PNKD | 0.07 | 0.08 | lasso | 7 | 0.08 | 4.8e-12 | 5.5 | -5.5 | 5.0e-08 | 0.02 | 0.01 | 0.99 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | TMBIM1 | 0.02 | 0.01 | blup | 49 | 0.02 | 2.6e-03 | 4.9 | -5.2 | 2.5e-07 | 0.01 | 0.04 | 0.86 | FALSE |