[Hub]/) : Traits : Waist Hip Ratio (WHR) :

chr2:218,382,236-220,733,584

Best TWAS P=3.53e-10 · Best GWAS P=4.47e-11 conditioned to 2.84e-11

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Adipose Subcutaneous RP11-548H3.1 0.07 0.01 lasso 7 0.01 4.0e-02 4.5 -6.3 3.5e-10 0.01 0.06 0.50 TRUE
2 GTEx Adrenal Gland PNKD 0.20 0.16 lasso 5 0.19 1.6e-07 5.2 -5.3 1.1e-07 0.01 0.03 0.96 FALSE
3 GTEx Artery Coronary RP11-378A13.1 0.34 0.36 lasso 8 0.38 1.2e-13 5.0 -5.3 1.4e-07 0.02 0.05 0.95 FALSE
4 GTEx Brain Cerebellar Hemisphere RP11-378A13.1 0.53 0.57 enet 24 0.60 3.3e-19 4.6 -5.1 3.1e-07 0.01 0.12 0.87 FALSE
5 GTEx Brain Hypothalamus RP11-378A13.1 0.37 0.44 enet 17 0.45 5.6e-12 4.6 -5.2 1.9e-07 0.00 0.04 0.96 FALSE
6 GTEx Heart Atrial Appendage TMBIM1 0.11 0.09 lasso 2 0.08 1.8e-04 4.9 -5.3 1.1e-07 0.01 0.02 0.97 FALSE
7 GTEx Lung PNKD 0.13 0.04 enet 10 0.03 3.7e-03 5.6 -5.2 1.9e-07 0.03 0.02 0.98 FALSE
8 GTEx Skin Not Sun Exposed Suprapubic PNKD 0.28 0.28 enet 9 0.26 9.7e-15 5.3 -5.3 1.0e-07 0.01 0.02 0.98 FALSE
9 GTEx Skin Not Sun Exposed Suprapubic RP11-378A13.1 0.26 0.25 lasso 8 0.28 5.6e-16 5.2 -5.2 1.5e-07 0.01 0.06 0.93 FALSE
10 GTEx Skin Sun Exposed Lower leg PNKD 0.27 0.29 lasso 8 0.34 3.9e-29 5.2 -5.4 6.5e-08 0.01 0.02 0.98 FALSE
11 GTEx Spleen RP11-378A13.1 0.37 0.41 enet 27 0.41 1.2e-11 4.9 -5.7 9.6e-09 0.01 0.05 0.95 FALSE
12 GTEx Stomach RP11-378A13.1 0.32 0.32 enet 20 0.34 3.4e-17 4.6 -5.3 9.0e-08 0.01 0.17 0.82 FALSE
13 GTEx Testis TMBIM1 0.27 0.13 enet 20 0.15 2.7e-07 5.3 -5.7 1.5e-08 0.00 0.03 0.96 FALSE
14 GTEx Thyroid PNKD 0.13 0.12 enet 13 0.14 6.3e-11 5.5 -5.5 4.4e-08 0.01 0.01 0.99 FALSE
15 GTEx Thyroid SLC23A3 0.11 0.04 lasso 7 0.03 3.8e-03 -4.9 -5.2 1.9e-07 0.00 0.02 0.91 FALSE
16 GTEx Whole Blood RP11-378A13.1 0.11 0.13 enet 18 0.15 1.6e-13 4.9 -5.3 1.5e-07 0.00 0.08 0.91 FALSE
17 METSIM Adipose ARPC2 0.03 0.02 blup 458 0.01 2.2e-03 4.1 -5.3 9.9e-08 -0.01 0.03 0.96 FALSE
18 METSIM Adipose PNKD 0.07 0.08 lasso 7 0.08 4.8e-12 5.5 -5.5 5.0e-08 0.02 0.01 0.99 FALSE
19 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma TMBIM1 0.02 0.01 blup 49 0.02 2.6e-03 4.9 -5.2 2.5e-07 0.01 0.04 0.86 FALSE