Best TWAS P=6.17e-11 · Best GWAS P=4.73e-10 conditioned to 0.284
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | C1QTNF3 | 0.14 | 0.13 | lasso | 5 | 0.12 | 1.1e-14 | -6.1 | -6.3 | 3.3e-10 | 0.88 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Male) | AMACR | 0.19 | -0.01 | lasso | 2 | -0.01 | 6.9e-01 | -5.3 | 5.3 | 1.0e-07 | -0.79 | 0.02 | 0.50 | FALSE |
| 3 | GTEx | Whole Blood | AMACR | 0.36 | 0.32 | lasso | 2 | 0.32 | 9.1e-30 | -6.0 | -5.9 | 3.4e-09 | 0.79 | 0.01 | 0.99 | FALSE |
| 4 | NTR | Blood | AMACR | 0.05 | 0.04 | bslmm | 400 | 0.04 | 1.5e-12 | -6.0 | -5.3 | 9.8e-08 | 0.76 | 0.01 | 0.99 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | C1QTNF3 | 0.10 | 0.06 | bslmm | 398 | 0.07 | 4.4e-09 | -6.1 | -6.5 | 8.0e-11 | 0.88 | 0.00 | 1.00 | FALSE |
| 6 | YFS | Blood | AMACR | 0.07 | 0.05 | lasso | 9 | 0.06 | 1.8e-17 | -6.1 | -6.5 | 6.2e-11 | 0.87 | 0.01 | 0.99 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Adenocarcinoma | C1QTNF3 | 0.03 | 0.01 | blup | 66 | 0.01 | 6.4e-02 | -6.0 | 5.3 | 1.3e-07 | -0.77 | 0.01 | 0.62 | FALSE |