Best TWAS P=6.88e-13 · Best GWAS P=6.2e-45 conditioned to 2.94e-35
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DDX4 | 0.08 | 0.07 | bslmm | 390 | 0.08 | 1.7e-10 | 6.03 | -7.0 | 3.1e-12 | -0.04 | 0.32 | 0.68 | FALSE |
| 2 | GTEx | Brain Cerebellum | SLC38A9 | 0.26 | 0.13 | lasso | 4 | 0.10 | 7.4e-04 | 6.52 | 5.6 | 2.2e-08 | 0.04 | 0.16 | 0.68 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | GPX8 | 0.06 | 0.00 | lasso | 4 | 0.01 | 1.6e-01 | 3.99 | -5.2 | 1.8e-07 | -0.05 | 0.11 | 0.52 | FALSE |
| 4 | GTEx | Breast Mammary Tissue | CTD-2310F14.1 | 0.14 | -0.01 | enet | 23 | 0.01 | 6.7e-02 | -0.48 | -6.6 | 5.3e-11 | -0.27 | 0.10 | 0.05 | TRUE |
| 5 | GTEx | Breast Mammary Tissue (Female) | GPX8 | 0.04 | 0.00 | lasso | 2 | 0.03 | 5.0e-02 | 7.35 | -7.2 | 6.9e-13 | -0.05 | 0.04 | 0.35 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | DDX4 | 0.07 | 0.08 | lasso | 2 | 0.07 | 1.5e-09 | 6.12 | -6.2 | 6.5e-10 | -0.05 | 0.80 | 0.20 | FALSE |
| 7 | The Cancer Genome Atlas | Breast Invasive Carcinoma | PPAP2A | 0.06 | 0.03 | lasso | 1 | 0.03 | 1.1e-06 | 6.48 | -6.5 | 9.4e-11 | -0.02 | 0.01 | 0.99 | FALSE |
| 8 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPAP2A | 0.14 | 0.00 | blup | 58 | 0.03 | 4.4e-04 | 6.48 | -6.1 | 1.3e-09 | 0.02 | 0.00 | 0.74 | FALSE |
| 9 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | SLC38A9 | 0.04 | 0.02 | enet | 7 | 0.03 | 6.6e-03 | 7.32 | 6.4 | 1.4e-10 | 0.03 | 0.03 | 0.57 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC38A9 | 0.03 | 0.04 | blup | 52 | 0.04 | 2.0e-04 | 6.48 | 6.9 | 4.1e-12 | 0.03 | 0.13 | 0.84 | FALSE |