Hub : Genes

C1QTNF3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1420 0.0320 2.4e-09 0.129 0.075 0.115 0.106 0.122 2.2e-15 1.8e-09 8.0e-14 8.6e-13 1.1e-14
2 ROSMAP Brain Pre-frontal Cortex 0.1019 0.0276 1.1e-06 0.063 0.062 0.067 0.068 0.064 1.4e-08 1.8e-08 5.9e-09 4.4e-09 1.2e-08
3 TCGA Lung Adenocarcinoma 0.0327 0.0199 8.7e-03 0.009 0.006 -0.002 NA 0.000 2.6e-02 6.4e-02 6.8e-01 NA 3.7e-01

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.4 0.6 0.8 -0.8 -0.9 0.7
Bipolar Disorder or Schizophrenia 0.9 2.2 3.4 -1.9 -1.5 1.0
Depressed Affect (Nagel 2018) 0.0 0.0 0.0 -0.1 -0.0 0.0
Depression (Nagel 2018) 0.9 1.3 2.0 -1.0 -1.0 1.4
Intelligence (Savage-Jansen 2018) 0.3 1.0 1.7 1.0 0.3 -1.3
Neuroticism (Nagel 2018) 0.6 1.3 1.5 -1.1 -1.2 1.2
Schizophrenia (2018) 0.8 1.7 3.1 -1.8 -1.3 0.5
Schizophrenia vs Biploar Disorder 0.3 0.4 0.7 -0.7 -0.8 0.3
Worry (Nagel 2018) 0.1 0.3 0.4 -0.5 -0.6 0.4
Alzheimer’s Disease (in mother) 0.3 0.4 0.9 0.9 0.3 -0.4
Alzheimer’s Disease (in father) 0.0 0.0 0.0 0.1 -0.2 -0.0
Alzheimer’s Disease (including proxy) 0.1 0.1 0.1 0.3 -0.3 0.3
Crohns Disease (2017) 0.1 0.2 0.7 0.1 -0.0 0.8
Irritable Bowel Disease (IBD) 0.4 1.0 2.2 -0.6 -0.6 1.5
Ulcerative Colitis (UC) 0.4 0.8 1.4 -0.7 -0.7 1.2
Major Depression (MDD) 1.3 1.5 3.3 0.9 0.7 -1.8
Reaction Time 0.2 0.4 1.0 -0.1 -0.3 -1.0
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.4 0.6 0.2 -1.2
Breast Cancer 2.3 5.4 7.6 2.0 2.8 -2.1
Ovarian Cancer 0.1 0.1 0.3 -0.1 -0.1 -0.5
Prostate Cancer 0.1 0.1 0.2 -0.4 0.1 -0.4
Age at First Birth 1.4 2.0 2.7 -1.4 -1.6 1.1
Bipolar Disorder (2011) 0.7 0.6 1.0 -0.7 -1.0 0.7
Body Mass Index (BMI) (2010) 1.4 1.9 2.5 -1.1 -1.6 1.4
Coronary Artery Disease (CAD) 1.8 2.2 2.4 -1.4 -1.6 1.5
Crohns Disease (2012) 0.0 0.1 0.2 0.4 -0.1 0.2
Mean Putamen Volume 0.1 0.2 0.5 0.7 0.1 0.2
Fasting Glucose 0.3 0.4 0.5 -0.5 -0.7 0.6
HbA1C 0.4 0.4 0.6 0.7 0.4 -0.8
HDL Cholesterol 0.1 0.2 0.3 -0.4 0.1 0.5
LDL Cholesterol 0.8 1.2 2.8 -1.0 -0.2 1.7
Lupus 0.4 0.5 1.4 1.2 0.5 -0.1
Neuroticism (2016) 0.5 0.8 1.3 0.8 1.1 -0.6
Primary Biliary Cirrhosis 2.6 3.7 5.1 -1.6 -1.9 2.3
Rheumatoid Arthritis 0.0 0.1 0.2 0.0 0.4 -0.1
Schizophrenia (2014) 0.2 0.4 0.8 -0.9 -0.7 0.1
Triglycerides 0.2 0.4 0.6 -0.7 -0.8 0.1
Type 2 Diabetes (T2D) (2012) 0.2 0.3 0.7 -0.0 -0.9 0.2
Ulcerative Colitis 0.1 0.1 0.1 -0.3 0.3 0.2
Blood Eosinophil Count 0.1 0.4 1.1 1.0 0.5 -0.2
Blood Platelet Count 0.0 0.0 0.1 -0.1 -0.3 -0.1
Blood Red Count 0.2 1.7 2.2 -1.4 -1.5 1.0
Blood White Count 0.1 0.4 0.6 0.8 -0.4 -0.7
Heel T-Score 0.2 1.7 4.5 -0.5 -0.5 2.1
BMI 0.7 4.2 6.5 2.5 0.9 -2.3
Height 0.0 0.9 1.7 -0.8 -0.7 1.3
Waist Hip Ratio (WHR) 8.1 36.5 42.2 -6.3 -6.5 5.3
Systolic Blood Pressure 0.2 1.2 2.3 -1.5 -0.5 1.0
Smoking Status 0.1 0.2 0.5 0.2 -0.7 0.1
Allergy or Eczema 0.2 0.4 0.5 0.6 0.7 -0.6
Cardiovascular Disease 0.2 0.5 0.8 0.9 0.8 -0.6
Hypothyroidism (self reported) 0.1 0.1 0.3 -0.3 -0.3 0.5
Respiratory disease 0.0 0.1 0.1 0.4 0.4 0.2
Type 2 Diabetes (T2D) (2018) 0.6 1.1 2.2 -0.7 -1.5 0.8
Lung FEV1/FVC ratio 0.5 2.4 4.6 2.1 0.5 -1.5
Lung FVC 0.4 2.0 3.6 -1.4 -0.6 1.9
Neuroticism 0.0 0.1 0.1 0.4 -0.1 -0.3
Chronotype (morning person) 0.1 0.1 0.3 0.1 0.6 0.1
Hair Pigment 0.1 3.6 7.7 2.8 0.4 -1.7
Tanning 0.1 1.4 3.2 -0.7 0.7 1.8
Hand grip strength (left) 0.4 1.1 1.6 -1.3 -0.8 1.1
Number of treatments/medications taken 1.0 1.8 4.0 2.0 1.1 -0.5
Average weekly spirits intake 0.6 0.7 1.4 -1.2 -0.7 0.4
Sensitivity / hurt feelings 0.1 0.2 0.4 0.4 -0.4 -0.6
Frequency of depressed mood in last 2 weeks 0.2 0.2 0.3 0.4 -0.5 0.5
Hearing difficulty/problems: Yes 0.1 0.2 0.3 0.5 -0.2 0.6
Relative age of first facial hair 0.3 0.6 1.1 -0.7 -1.1 -0.2
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.4 0.0 -0.7 0.1
Ever used hormone-replacement therapy (HRT) 4.8 6.1 8.0 -2.1 -2.8 2.4
Ever had hysterectomy (womb removed) 2.4 2.7 4.1 -1.3 -2.0 1.5
Systolic blood pressure, automated reading 0.1 0.4 0.6 -0.6 -0.6 0.8
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.5 0.7 -0.0 -0.7
Angina 3.2 4.2 5.7 1.9 1.9 -2.4
Medication for hormone replacement therapy 0.8 0.9 1.5 -0.2 -1.1 1.2
Vitamin and mineral supplements 0.1 0.1 0.2 -0.4 0.1 0.1
Supplements: Zinc 0.5 0.6 1.1 1.1 0.6 -0.5
Medication: Co-codamol 0.5 0.6 1.2 -0.2 -0.8 1.1
Medication: Metformin 0.3 0.4 0.7 0.7 0.1 -0.8
Diabetes (father) 0.1 0.1 0.3 -0.2 -0.6 -0.2
Diabetes (mother) 0.4 0.5 0.6 -0.8 -0.8 0.5
Severe depression (siblings) 0.8 0.9 2.2 -0.3 -0.7 1.5
Pack years adult smoking proportion 0.8 1.3 1.8 1.1 0.9 -1.3
Impedance of leg (right) 0.2 1.1 1.7 -0.9 -0.9 1.3
Leg fat-free mass (left) 0.3 1.8 2.5 1.6 1.0 -1.4
Trunk fat percentage 0.4 1.4 2.7 -0.4 -1.6 1.2
Hand grip strength (right) 1.2 3.2 4.6 -2.1 -1.6 1.5
Townsend deprivation index at recruitment 0.2 0.3 0.5 0.5 0.5 -0.7
Current tobacco smoking 0.4 0.6 0.7 0.8 0.7 -0.8
Average weekly fortified wine intake 0.2 0.3 0.5 -0.6 -0.7 0.0
Maternal smoking around birth 1.8 2.7 4.0 1.7 2.0 -1.1
Fed-up feelings 0.4 0.8 1.1 0.9 1.1 -0.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.0 0.1 0.2 -0.1
Relative age voice broke 0.1 0.2 0.3 0.5 0.4 -0.4
Taking other prescription medications 1.0 1.6 3.0 1.7 1.0 -0.9
Age when periods started (menarche) 0.9 2.3 2.7 -1.4 -1.5 1.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 1.1 -1.0 -1.0 0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.0 2.4 3.2 -1.2 -1.5 1.8
Tinnitus: Yes, but not now, but have in the past 0.5 0.5 0.9 0.4 1.0 -0.7
Qualifications: CSEs or equivalent 0.6 0.8 1.1 0.7 0.9 -1.1
Serious illness, injury or assault to yourself 0.1 0.1 0.3 0.5 0.2 0.4
High blood pressure 0.1 0.2 0.5 0.7 0.4 -0.1
Hayfever, allergic rhinitis or eczema 0.7 1.5 1.8 1.3 1.4 -1.0
Multivitamins +/- minerals 0.2 0.3 0.6 0.1 -0.5 0.8
Stomach or abdominal pain in last month 0.7 0.8 1.4 1.2 0.3 -1.0
Supplements: Glucosamine 0.3 0.4 0.6 -0.6 -0.7 0.8
Diverticular disease/diverticulitis (self-reported) 0.4 0.5 1.1 -0.5 -1.1 0.4
Medication: Atenolol 0.1 0.2 0.4 0.6 0.3 -0.1
Medication: Levothyroxine sodium 0.1 0.1 0.2 -0.3 -0.4 0.3
Sitting height 0.6 3.9 5.3 2.3 2.0 -1.6
Chronic bronchitis/emphysema (father) 0.2 0.2 0.3 0.5 0.4 -0.3
High blood pressure (mother) 0.5 0.6 1.6 0.5 1.3 0.1
Body mass index (BMI) 0.2 0.7 1.2 1.1 -0.4 -0.9
Impedance of leg (left) 0.3 1.4 2.2 -1.1 -1.0 1.5
Leg predicted mass (left) 0.3 1.8 2.5 1.6 1.0 -1.4
Trunk fat mass 0.1 0.3 0.7 0.5 -0.8 0.3
Waist circumference 0.5 1.9 5.1 -0.7 -2.3 0.3
Number of incorrect matches in round 0.5 0.8 0.8 -0.8 -0.9 0.9
Past tobacco smoking 0.4 0.8 1.3 0.8 1.2 -0.6
Alcohol usually taken with meals 0.6 0.9 1.8 0.9 0.1 -1.4
Nervous feelings 0.1 0.1 0.1 0.4 0.3 -0.3
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 2.4 -1.1 -1.5 1.2
Hearing difficulty/problems with background noise 0.1 0.2 0.5 0.7 0.0 0.3
Hair/balding pattern: Pattern 2 0.2 0.3 0.8 -0.9 -0.0 0.3
Had menopause 0.5 0.6 0.7 0.8 0.7 -0.8
Had other major operations 4.0 4.9 6.1 -2.5 -2.1 2.1
Forced vital capacity (FVC) 0.7 2.7 4.1 -1.9 -0.7 2.0
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.7 0.0 -0.3 0.8
Ever unenthusiastic/disinterested for a whole week 0.5 0.6 1.1 1.1 0.7 -0.4
Qualifications: None of the above 0.0 0.1 0.1 0.4 -0.2 0.0
Financial difficulties in last 2 years 0.6 0.8 1.1 0.9 1.0 -0.6
Mouth/teeth dental problems 0.6 0.9 1.6 1.0 1.3 -0.5
Heart attack 1.3 1.7 2.5 1.6 1.3 -0.9
Allergy 1.0 2.2 2.8 -1.7 -1.4 1.4
Pain all over the body in last month 0.2 0.2 0.3 -0.5 -0.0 0.5
Diabetes (self-reported) 0.1 0.1 0.4 -0.2 -0.6 -0.2
Hayfever/allergic rhinitis (self-reported) 1.7 2.3 3.1 1.2 1.6 -1.8
Medication: Ramipril 0.7 0.9 1.2 1.1 0.6 -1.1
Medication: Simvastatin 1.9 2.8 4.6 1.1 1.6 -2.1
Fluid intelligence score 1.2 2.5 3.1 1.8 1.3 -1.6
Illnesses of siblings 0.2 0.2 0.7 0.1 0.0 -0.8
Neuroticism score 0.1 0.2 0.4 0.6 0.2 -0.4
Weight 0.3 1.2 2.3 1.5 0.2 -1.2
Impedance of arm (right) 1.8 8.3 13.1 -2.9 -1.9 3.6
Arm fat percentage (right) 0.1 0.4 0.9 0.2 -1.0 0.4
Trunk fat-free mass 1.0 5.8 7.2 2.6 1.9 -2.7
Hip circumference 0.9 3.7 6.2 2.5 1.3 -1.8
Time employed in main current job 0.4 0.5 0.7 0.9 0.5 -0.7
Alcohol intake versus 10 years previously 0.1 0.1 0.2 -0.4 0.1 0.3
Father’s age at death 0.2 0.3 0.7 -0.2 -0.8 0.4
Worrier / anxious feelings 0.1 0.2 0.4 0.0 -0.7 0.4
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.4 0.6 -0.3 -0.3
Falls in the last year 0.0 0.1 0.1 0.3 -0.2 0.2
Hair/balding pattern: Pattern 3 0.9 1.3 2.3 -0.5 -1.2 1.5
Number of live births 0.2 0.3 0.4 -0.6 -0.4 0.6
Forced expiratory volume in 1-second (FEV1) 0.4 1.4 2.4 -1.2 -0.6 1.5
Pulse rate 0.0 0.0 0.1 -0.1 0.0 -0.3
Happiness 0.2 0.3 0.5 -0.2 -0.7 0.6
Noisy workplace 0.0 0.0 0.0 -0.1 -0.2 -0.2
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.5 0.6 0.7 -0.6
Serious illness, injury or assault of a close relative in last 2 years 0.7 0.8 0.9 -1.0 -0.8 0.8
Mouth/teeth dental problems: Dentures 0.4 0.7 1.2 -1.1 -0.9 0.4
Asthma 0.7 1.4 1.8 1.2 1.3 -1.0
Medication: Ibuprofen (e.g. Nurofen) 0.4 0.5 1.2 1.1 0.6 0.3
Medication: Cholesterol lowering 4.1 6.3 6.9 2.4 2.5 -2.6
Depression (self-reported) 1.2 1.5 2.2 -0.4 -1.5 1.4
Medication: Lansoprazole 0.1 0.1 0.2 0.5 0.0 0.5
Prospective memory result 0.4 0.5 1.0 -1.0 -0.5 0.5
Lung cancer (father) 4.2 4.9 6.7 -1.8 -2.6 2.2
Illnesses of mother 2.8 3.5 4.8 -2.2 -2.0 1.3
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.3 4.3 -1.2 -1.0 2.1
Pulse wave Arterial Stiffness index 0.9 1.0 1.5 1.1 1.2 -0.5
Impedance of arm (left) 2.3 10.9 16.2 -3.4 -2.2 4.0
Arm fat mass (right) 0.1 0.3 0.5 0.7 -0.5 -0.2
Trunk predicted mass 1.1 6.4 8.1 2.7 2.0 -2.8
Standing height 0.1 1.0 1.6 1.0 1.3 -0.7
Length of working week for main job 0.8 0.9 2.0 1.4 0.5 -0.6
Exposure to tobacco smoke at home 0.1 0.1 0.3 0.5 -0.1 0.2
Breastfed as a baby 2.0 2.5 2.7 -1.5 -1.6 1.6
Tense / ‘highly strung’ 0.4 0.6 1.6 0.5 0.1 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.1 0.2 0.4 0.1 -0.3
Hair/balding pattern: Pattern 4 0.1 0.3 0.7 0.2 0.8 0.1
Birth weight of first child 0.4 0.8 0.9 -0.9 -1.0 0.8
Peak expiratory flow (PEF) 0.6 1.4 1.7 -1.3 -1.1 1.2
Pulse wave reflection index 0.7 0.9 1.6 1.3 0.9 -0.3
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.1 -0.4 0.4 -0.3
Loud music exposure frequency 1.7 1.8 3.2 1.3 1.8 -0.8
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 0.6 -0.5 0.7 0.7
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.0 0.5 0.2 -1.0
Blood clot in the leg (DVT) 0.3 0.3 0.8 0.4 -0.1 -0.9
Medication: Paracetamol 1.3 2.2 3.3 1.7 1.8 -0.6
Headache pain in last month 0.7 1.2 1.5 1.1 0.9 -1.2
Medication for cholesterol, blood pressure or diabetes 4.0 6.6 6.9 -2.5 -2.6 2.6
Glaucoma (self-reported) 3.6 4.2 7.1 2.2 2.7 -0.9
Gout (self-reported) 0.6 0.8 1.2 -0.4 -1.1 1.0
Hypothyroidism/myxoedema (self-reported) 0.1 0.3 0.6 -0.3 -0.4 0.8
Medication: Amlodipine 4.5 6.3 6.5 2.5 2.5 -2.5
Medication: Ventolin 100micrograms inhaler 0.6 0.8 1.4 -1.2 -0.6 0.7
Birth weight 0.0 0.1 0.1 0.2 0.3 0.1
Chronic bronchitis/emphysema (mother) 0.2 0.2 0.3 0.5 0.3 -0.5
High blood pressure (siblings) 1.4 2.1 3.0 1.7 1.7 -0.6
Forced vital capacity (FVC), Best measure 0.6 2.3 4.7 -1.3 -0.6 2.2
Body fat percentage 0.2 0.8 1.8 -0.1 -1.3 0.8
Leg fat percentage (right) 0.1 0.5 1.2 0.5 -1.1 0.0
Arm fat-free mass (right) 0.9 4.5 6.2 2.3 1.4 -2.5
Exposure to tobacco smoke outside home 0.9 1.2 2.2 -1.5 -1.1 0.6
Comparative body size at age 10 0.4 1.2 2.1 0.7 1.0 -1.5
Number of full brothers 0.0 0.0 0.1 -0.3 -0.0 0.0
Worry too long after embarrassment 0.1 0.2 0.4 -0.1 -0.3 0.6
Seen a psychiatrist for nerves, anxiety, tension or depression 0.2 0.3 0.5 0.7 -0.1 -0.5
Wheeze or whistling in the chest in last year 0.1 0.1 0.4 0.6 0.0 -0.0
Number of children fathered 1.1 1.2 2.5 1.6 0.8 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 0.8 -0.9 -0.2 0.9
Age at first live birth 0.0 0.1 0.1 -0.4 0.0 0.2
Pulse wave peak to peak time 0.7 0.8 1.2 -1.0 -1.1 0.3
Health satisfaction 1.5 2.0 3.0 1.3 1.1 -1.7
Shortness of breath walking on level ground 0.2 0.3 0.7 -0.0 -0.4 0.8
Qualifications: College or University degree 0.2 0.6 1.1 -1.1 -0.8 0.3
Eye problems/disorders: None of the above 0.1 0.2 0.5 -0.7 -0.0 0.1
Mouth/teeth dental problems: Loose teeth 0.1 0.1 0.2 -0.4 -0.0 -0.2
Emphysema/chronic bronchitis 0.1 0.1 0.1 -0.4 0.2 0.0
Medication for pain relief, constipation, heartburn 0.4 0.6 1.4 -1.2 -0.6 0.1
Neck or shoulder pain in last month 1.1 1.6 2.2 1.5 0.8 -1.4
Medication: Blood pressure 1.9 3.4 3.8 1.7 1.8 -1.9
Angina (self-reported) 3.8 4.9 6.7 2.1 1.9 -2.6
Migraine (self-reported) 0.3 0.3 0.5 0.4 0.7 -0.6
Medication: Ibuprofen 0.4 0.5 1.1 1.1 0.6 0.0
Medication: Allopurinol 0.2 0.3 0.5 -0.1 -0.6 0.7
Medication: Omeprazole 0.3 0.4 0.9 0.0 -1.0 0.4
Medication: Seretide 50 evohaler 0.3 0.4 0.6 -0.6 -0.4 0.7
Mean time to correctly identify matches 0.1 0.3 0.6 -0.5 -0.8 0.0
Heart disease (mother) 2.8 3.4 5.3 1.7 2.3 -1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.5 1.7 3.0 -1.4 -1.7 0.4
Whole body fat mass 0.1 0.3 0.5 0.7 -0.7 -0.0
Leg fat mass (right) 0.2 0.7 1.5 1.2 -0.2 -0.8
Arm predicted mass (right) 0.9 4.4 6.0 2.3 1.4 -2.5
Pulse rate, automated reading 0.2 0.7 0.9 0.8 0.6 -1.0
Alcohol intake frequency. 0.1 0.2 0.5 0.7 0.4 0.1
Comparative height size at age 10 0.1 0.4 0.9 0.6 1.0 -0.2
Number of full sisters 0.1 0.1 0.1 -0.2 -0.1 0.4
Suffer from ‘nerves’ 1.7 2.7 3.5 1.9 1.2 -1.8
Overall health rating 1.9 4.1 5.0 2.2 1.8 -2.0
Chest pain or discomfort 0.6 0.9 2.6 1.6 0.3 -0.3
Had major operations 0.1 0.1 0.4 0.6 0.2 -0.1
Age at last live birth 0.7 1.0 1.3 -0.9 -1.1 1.0
Family relationship satisfaction 0.5 0.6 0.8 -0.8 -0.9 0.6
Leg pain on walking 0.5 0.6 0.8 -0.5 -0.9 0.9
Qualifications: NVQ or HND or HNC or equivalent 1.1 1.3 1.7 0.7 1.3 -1.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.4 -0.8 -0.7 1.2
Illness, injury, bereavement, stress in last 2 years 0.0 0.1 0.1 -0.0 -0.4 0.0
Medication: Aspirin 1.3 1.7 2.1 1.4 1.3 -1.2
Supplements: Vitamin C 4.6 5.5 5.8 2.3 2.3 -2.4
Knee pain experienced in last month 0.6 1.0 1.5 1.2 0.5 -1.0
Hypertension (Self-reported) 0.3 0.7 1.2 1.1 0.8 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.2 0.2 0.5 0.7 -0.0 0.3
Illnesses of father: Heart disease 0.5 0.7 1.1 0.9 0.5 -1.1
Illnesses of siblings: Diabetes 3.2 3.9 4.8 -2.2 -2.0 1.7
Smoking status: Previous 0.3 0.4 0.8 -0.6 -0.9 0.5
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.3 0.5 -0.5 0.2 0.7
Whole body fat-free mass 0.7 4.2 5.2 2.3 1.6 -2.2
Leg fat-free mass (right) 0.3 1.7 2.2 1.5 1.0 -1.3
Arm fat percentage (left) 0.2 0.7 1.4 -0.1 -1.2 0.7
Average weekly red wine intake 0.2 0.2 0.4 0.6 0.3 -0.5
Handedness (chirality/laterality): Left-handed 9.0 10.9 13.0 3.6 2.9 -3.3
Mood swings 0.1 0.3 0.6 0.8 0.3 0.3
Loneliness, isolation 0.3 0.4 0.7 -0.8 -0.8 0.1
Long-standing illness, disability or infirmity 0.1 0.1 0.2 0.5 -0.1 0.4
Ever had bowel cancer screening 0.1 0.1 0.1 -0.2 -0.4 0.1
Diabetes diagnosed by doctor 0.1 0.2 0.5 -0.1 -0.7 0.1
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.1 1.6 -1.3 -1.2 0.5
Friendships satisfaction 0.0 0.0 0.0 0.1 0.1 0.0
Qualifications: nursing, teaching 0.0 0.0 0.1 0.0 -0.2 0.3
Commuting to job workplace: Walk 0.2 0.2 0.6 -0.8 -0.0 0.0
Eye problems/disorders: Cataract 0.4 0.5 0.6 -0.6 -0.7 0.8
Mouth/teeth dental problems: Mouth ulcers 0.0 0.0 0.1 0.2 0.1 0.0
Medication for cholesterol 0.7 1.1 2.0 0.5 1.0 -1.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.1 0.1 0.1 0.3 0.1 0.4
Back pain experienced in last month 0.2 0.3 0.7 0.8 0.1 -0.6
Mineral and other dietary supplements 0.2 0.2 0.3 -0.6 0.2 0.5
Breast cancer (self-reported) 0.7 0.8 1.0 -1.0 -0.8 0.9
Asthma (self-reported) 0.7 1.4 2.2 1.2 1.5 -0.8
Osteoporosis (self-reported) 0.1 0.2 0.3 0.2 -0.4 -0.5
Osteoarthritis (self-reported) 0.9 1.1 1.7 1.3 1.1 -0.7
Medication: Aspirin 1.2 1.5 1.9 1.3 1.1 -1.4
Medication: Gliclazide 0.4 0.4 0.5 -0.7 -0.6 0.6
Illnesses of father: None of the above (group 1) 1.5 1.8 2.2 -1.5 -1.4 1.1
Smoking status: Current 0.1 0.2 0.3 0.5 0.2 -0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.1 2.0 -0.9 -0.7 1.4
Whole body water mass 0.8 4.3 5.4 2.3 1.6 -2.2
Leg predicted mass (right) 0.3 1.7 2.3 1.5 1.0 -1.3
Arm fat mass (left) 0.1 0.3 0.4 0.6 -0.6 -0.2
Number of self-reported non-cancer illnesses 1.3 2.3 4.3 2.1 1.0 -1.2
Average weekly champagne plus white wine intake 0.1 0.1 0.1 0.4 -0.1 -0.4
Miserableness 0.1 0.1 0.2 0.4 0.3 -0.2
Guilty feelings 1.3 2.0 2.4 -1.5 -1.2 1.6
Wears glasses or contact lenses 0.4 0.5 0.8 0.9 0.4 -0.6
Ever taken oral contraceptive pill 0.4 0.5 0.9 -0.9 -0.6 0.4
Hearing aid user 1.0 1.1 1.5 1.1 1.2 -0.8
Mother’s age at death 1.4 1.8 2.8 -1.5 -1.7 0.4
Financial situation satisfaction 1.4 1.7 2.3 1.5 1.0 -1.4
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.1 0.9 -0.1 -1.0
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.5 -0.0 -0.2
Eye problems/disorders: Glaucoma 1.0 1.1 1.4 1.0 1.2 1.0
Medication: Blood pressure 1.0 2.0 2.5 -1.1 -1.4 1.6
Pain type(s) experienced in last month: Hip pain 2.8 3.5 6.4 2.5 1.4 -1.5
Supplements: Fish oil (including cod liver oil) 0.4 0.5 1.0 -0.4 -1.0 0.5
High cholesterol (Self-reported) 0.7 1.3 1.5 1.0 1.2 -1.1
Medication: Bendroflumethiazide 0.2 0.2 0.5 -0.3 -0.4 0.7
Medication: Paracetamol 0.6 1.0 1.6 1.2 1.2 0.1
Medication: Lisinopril 0.2 0.2 0.7 -0.8 -0.2 0.2
Medication: Atorvastatin 0.1 0.2 0.3 -0.3 -0.3 0.6
Illnesses of father: High blood pressure 0.3 0.3 0.9 0.3 0.9 -0.1
Alcohol drinker status: Never 3.4 4.0 5.5 2.0 2.3 -1.7
Ever smoked 0.7 1.2 1.4 -1.0 -1.2 1.0
Basal metabolic rate 0.6 3.4 4.5 2.1 1.3 -2.0
Leg fat percentage (left) 0.1 0.5 1.4 0.4 -1.2 0.1
Arm fat-free mass (left) 1.1 5.6 7.7 2.6 1.5 -2.8
Number of operations (self-reported) 0.0 0.1 0.1 -0.0 -0.4 0.1
Average weekly beer plus cider intake 0.0 0.0 0.0 0.1 -0.1 -0.1
Irritability 0.8 1.3 1.5 1.2 1.2 -1.1
Risk taking 0.2 0.3 0.6 -0.8 0.1 0.6
Ever had prostate specific antigen (PSA) test 1.3 1.5 2.5 1.3 1.6 -0.5
Fractured/broken bones in last 5 years 0.1 0.1 0.3 0.0 -0.3 -0.6
Age started oral contraceptive pill 0.5 0.6 1.6 -0.3 -1.3 0.1
Diastolic blood pressure, automated reading 0.0 0.1 0.2 0.3 0.3 -0.4
Ever depressed for a whole week 0.0 0.1 0.1 -0.1 0.1 0.4
Unable to work because of sickness or disability 0.5 0.7 1.1 1.0 0.6 -0.8
Commuting to job workplace: Cycle 1.1 1.3 2.8 -1.7 -0.3 1.0
Myopia 0.8 1.1 1.6 1.1 1.3 -0.8
Vascular/heart problems diagnosed by doctor 0.3 0.8 1.5 -1.2 -0.7 0.7
Cholesterol lowering medication 0.0 0.0 0.1 -0.0 -0.2 0.1
Medication: Omeprazole (e.g. Zanprol) 0.3 0.4 0.9 0.1 -1.0 0.4
Pain experienced in last month 0.5 0.8 1.8 -1.3 -0.1 0.8
Supplements: Calcium 1.6 1.8 2.9 1.2 1.1 -1.7
Basal cell carcinoma (self-reported) 0.4 0.4 1.1 -1.0 -0.1 0.5
Heart attack/myocardial infarction (self-reported) 1.0 1.3 2.0 1.4 1.1 -0.8
Deep venous thrombosis (DVT) (self-reported) 0.4 0.5 1.1 0.6 0.1 -1.1
Heart disease (siblings) 0.0 0.0 0.1 -0.1 0.1 0.3
Alcohol drinker status: Previous 0.1 0.1 0.3 -0.1 -0.5 0.2
Pack years of smoking 0.5 0.8 1.2 0.9 0.6 -1.1
Impedance of whole body 1.4 7.1 9.9 -2.7 -2.0 3.2
Leg fat mass (left) 0.2 0.7 1.4 1.2 -0.3 -0.8
Arm predicted mass (left) 1.2 6.2 8.1 2.8 1.6 -2.8