Hub : Genes

C1QTNF3

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1420	0.0320	2.4e-09	0.129	0.075	0.115	0.106	0.122	2.2e-15	1.8e-09	8.0e-14	8.6e-13	1.1e-14
2	ROSMAP	Brain Pre-frontal Cortex	0.1019	0.0276	1.1e-06	0.063	0.062	0.067	0.068	0.064	1.4e-08	1.8e-08	5.9e-09	4.4e-09	1.2e-08
3	TCGA	Lung Adenocarcinoma	0.0327	0.0199	8.7e-03	0.009	0.006	-0.002	NA	0.000	2.6e-02	6.4e-02	6.8e-01	NA	3.7e-01

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.4	0.6	0.8	-0.8	-0.9	0.7
Bipolar Disorder or Schizophrenia	0.9	2.2	3.4	-1.9	-1.5	1.0
Depressed Affect (Nagel 2018)	0.0	0.0	0.0	-0.1	-0.0	0.0
Depression (Nagel 2018)	0.9	1.3	2.0	-1.0	-1.0	1.4
Intelligence (Savage-Jansen 2018)	0.3	1.0	1.7	1.0	0.3	-1.3
Neuroticism (Nagel 2018)	0.6	1.3	1.5	-1.1	-1.2	1.2
Schizophrenia (2018)	0.8	1.7	3.1	-1.8	-1.3	0.5
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.7	-0.8	0.3
Worry (Nagel 2018)	0.1	0.3	0.4	-0.5	-0.6	0.4
Alzheimer’s Disease (in mother)	0.3	0.4	0.9	0.9	0.3	-0.4
Alzheimer’s Disease (in father)	0.0	0.0	0.0	0.1	-0.2	-0.0
Alzheimer’s Disease (including proxy)	0.1	0.1	0.1	0.3	-0.3	0.3
Crohns Disease (2017)	0.1	0.2	0.7	0.1	-0.0	0.8
Irritable Bowel Disease (IBD)	0.4	1.0	2.2	-0.6	-0.6	1.5
Ulcerative Colitis (UC)	0.4	0.8	1.4	-0.7	-0.7	1.2
Major Depression (MDD)	1.3	1.5	3.3	0.9	0.7	-1.8
Reaction Time	0.2	0.4	1.0	-0.1	-0.3	-1.0
Verbal and Numeric Reasoning (VNR)	0.3	0.6	1.4	0.6	0.2	-1.2
Breast Cancer	2.3	5.4	7.6	2.0	2.8	-2.1
Ovarian Cancer	0.1	0.1	0.3	-0.1	-0.1	-0.5
Prostate Cancer	0.1	0.1	0.2	-0.4	0.1	-0.4
Age at First Birth	1.4	2.0	2.7	-1.4	-1.6	1.1
Bipolar Disorder (2011)	0.7	0.6	1.0	-0.7	-1.0	0.7
Body Mass Index (BMI) (2010)	1.4	1.9	2.5	-1.1	-1.6	1.4
Coronary Artery Disease (CAD)	1.8	2.2	2.4	-1.4	-1.6	1.5
Crohns Disease (2012)	0.0	0.1	0.2	0.4	-0.1	0.2
Mean Putamen Volume	0.1	0.2	0.5	0.7	0.1	0.2
Fasting Glucose	0.3	0.4	0.5	-0.5	-0.7	0.6
HbA1C	0.4	0.4	0.6	0.7	0.4	-0.8
HDL Cholesterol	0.1	0.2	0.3	-0.4	0.1	0.5
LDL Cholesterol	0.8	1.2	2.8	-1.0	-0.2	1.7
Lupus	0.4	0.5	1.4	1.2	0.5	-0.1
Neuroticism (2016)	0.5	0.8	1.3	0.8	1.1	-0.6
Primary Biliary Cirrhosis	2.6	3.7	5.1	-1.6	-1.9	2.3
Rheumatoid Arthritis	0.0	0.1	0.2	0.0	0.4	-0.1
Schizophrenia (2014)	0.2	0.4	0.8	-0.9	-0.7	0.1
Triglycerides	0.2	0.4	0.6	-0.7	-0.8	0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.7	-0.0	-0.9	0.2
Ulcerative Colitis	0.1	0.1	0.1	-0.3	0.3	0.2
Blood Eosinophil Count	0.1	0.4	1.1	1.0	0.5	-0.2
Blood Platelet Count	0.0	0.0	0.1	-0.1	-0.3	-0.1
Blood Red Count	0.2	1.7	2.2	-1.4	-1.5	1.0
Blood White Count	0.1	0.4	0.6	0.8	-0.4	-0.7
Heel T-Score	0.2	1.7	4.5	-0.5	-0.5	2.1
BMI	0.7	4.2	6.5	2.5	0.9	-2.3
Height	0.0	0.9	1.7	-0.8	-0.7	1.3
Waist Hip Ratio (WHR)	8.1	36.5	42.2	-6.3	-6.5	5.3
Systolic Blood Pressure	0.2	1.2	2.3	-1.5	-0.5	1.0
Smoking Status	0.1	0.2	0.5	0.2	-0.7	0.1
Allergy or Eczema	0.2	0.4	0.5	0.6	0.7	-0.6
Cardiovascular Disease	0.2	0.5	0.8	0.9	0.8	-0.6
Hypothyroidism (self reported)	0.1	0.1	0.3	-0.3	-0.3	0.5
Respiratory disease	0.0	0.1	0.1	0.4	0.4	0.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.2	-0.7	-1.5	0.8
Lung FEV1/FVC ratio	0.5	2.4	4.6	2.1	0.5	-1.5
Lung FVC	0.4	2.0	3.6	-1.4	-0.6	1.9
Neuroticism	0.0	0.1	0.1	0.4	-0.1	-0.3
Chronotype (morning person)	0.1	0.1	0.3	0.1	0.6	0.1
Hair Pigment	0.1	3.6	7.7	2.8	0.4	-1.7
Tanning	0.1	1.4	3.2	-0.7	0.7	1.8
Hand grip strength (left)	0.4	1.1	1.6	-1.3	-0.8	1.1
Number of treatments/medications taken	1.0	1.8	4.0	2.0	1.1	-0.5
Average weekly spirits intake	0.6	0.7	1.4	-1.2	-0.7	0.4
Sensitivity / hurt feelings	0.1	0.2	0.4	0.4	-0.4	-0.6
Frequency of depressed mood in last 2 weeks	0.2	0.2	0.3	0.4	-0.5	0.5
Hearing difficulty/problems: Yes	0.1	0.2	0.3	0.5	-0.2	0.6
Relative age of first facial hair	0.3	0.6	1.1	-0.7	-1.1	-0.2
Other serious medical condition/disability diagnosed by doctor	0.1	0.2	0.4	0.0	-0.7	0.1
Ever used hormone-replacement therapy (HRT)	4.8	6.1	8.0	-2.1	-2.8	2.4
Ever had hysterectomy (womb removed)	2.4	2.7	4.1	-1.3	-2.0	1.5
Systolic blood pressure, automated reading	0.1	0.4	0.6	-0.6	-0.6	0.8
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.5	0.7	-0.0	-0.7
Angina	3.2	4.2	5.7	1.9	1.9	-2.4
Medication for hormone replacement therapy	0.8	0.9	1.5	-0.2	-1.1	1.2
Vitamin and mineral supplements	0.1	0.1	0.2	-0.4	0.1	0.1
Supplements: Zinc	0.5	0.6	1.1	1.1	0.6	-0.5
Medication: Co-codamol	0.5	0.6	1.2	-0.2	-0.8	1.1
Medication: Metformin	0.3	0.4	0.7	0.7	0.1	-0.8
Diabetes (father)	0.1	0.1	0.3	-0.2	-0.6	-0.2
Diabetes (mother)	0.4	0.5	0.6	-0.8	-0.8	0.5
Severe depression (siblings)	0.8	0.9	2.2	-0.3	-0.7	1.5
Pack years adult smoking proportion	0.8	1.3	1.8	1.1	0.9	-1.3
Impedance of leg (right)	0.2	1.1	1.7	-0.9	-0.9	1.3
Leg fat-free mass (left)	0.3	1.8	2.5	1.6	1.0	-1.4
Trunk fat percentage	0.4	1.4	2.7	-0.4	-1.6	1.2
Hand grip strength (right)	1.2	3.2	4.6	-2.1	-1.6	1.5
Townsend deprivation index at recruitment	0.2	0.3	0.5	0.5	0.5	-0.7
Current tobacco smoking	0.4	0.6	0.7	0.8	0.7	-0.8
Average weekly fortified wine intake	0.2	0.3	0.5	-0.6	-0.7	0.0
Maternal smoking around birth	1.8	2.7	4.0	1.7	2.0	-1.1
Fed-up feelings	0.4	0.8	1.1	0.9	1.1	-0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	0.1	0.2	-0.1
Relative age voice broke	0.1	0.2	0.3	0.5	0.4	-0.4
Taking other prescription medications	1.0	1.6	3.0	1.7	1.0	-0.9
Age when periods started (menarche)	0.9	2.3	2.7	-1.4	-1.5	1.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	1.1	-1.0	-1.0	0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.0	2.4	3.2	-1.2	-1.5	1.8
Tinnitus: Yes, but not now, but have in the past	0.5	0.5	0.9	0.4	1.0	-0.7
Qualifications: CSEs or equivalent	0.6	0.8	1.1	0.7	0.9	-1.1
Serious illness, injury or assault to yourself	0.1	0.1	0.3	0.5	0.2	0.4
High blood pressure	0.1	0.2	0.5	0.7	0.4	-0.1
Hayfever, allergic rhinitis or eczema	0.7	1.5	1.8	1.3	1.4	-1.0
Multivitamins +/- minerals	0.2	0.3	0.6	0.1	-0.5	0.8
Stomach or abdominal pain in last month	0.7	0.8	1.4	1.2	0.3	-1.0
Supplements: Glucosamine	0.3	0.4	0.6	-0.6	-0.7	0.8
Diverticular disease/diverticulitis (self-reported)	0.4	0.5	1.1	-0.5	-1.1	0.4
Medication: Atenolol	0.1	0.2	0.4	0.6	0.3	-0.1
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.3	-0.4	0.3
Sitting height	0.6	3.9	5.3	2.3	2.0	-1.6
Chronic bronchitis/emphysema (father)	0.2	0.2	0.3	0.5	0.4	-0.3
High blood pressure (mother)	0.5	0.6	1.6	0.5	1.3	0.1
Body mass index (BMI)	0.2	0.7	1.2	1.1	-0.4	-0.9
Impedance of leg (left)	0.3	1.4	2.2	-1.1	-1.0	1.5
Leg predicted mass (left)	0.3	1.8	2.5	1.6	1.0	-1.4
Trunk fat mass	0.1	0.3	0.7	0.5	-0.8	0.3
Waist circumference	0.5	1.9	5.1	-0.7	-2.3	0.3
Number of incorrect matches in round	0.5	0.8	0.8	-0.8	-0.9	0.9
Past tobacco smoking	0.4	0.8	1.3	0.8	1.2	-0.6
Alcohol usually taken with meals	0.6	0.9	1.8	0.9	0.1	-1.4
Nervous feelings	0.1	0.1	0.1	0.4	0.3	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	2.4	-1.1	-1.5	1.2
Hearing difficulty/problems with background noise	0.1	0.2	0.5	0.7	0.0	0.3
Hair/balding pattern: Pattern 2	0.2	0.3	0.8	-0.9	-0.0	0.3
Had menopause	0.5	0.6	0.7	0.8	0.7	-0.8
Had other major operations	4.0	4.9	6.1	-2.5	-2.1	2.1
Forced vital capacity (FVC)	0.7	2.7	4.1	-1.9	-0.7	2.0
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.7	0.0	-0.3	0.8
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	1.1	1.1	0.7	-0.4
Qualifications: None of the above	0.0	0.1	0.1	0.4	-0.2	0.0
Financial difficulties in last 2 years	0.6	0.8	1.1	0.9	1.0	-0.6
Mouth/teeth dental problems	0.6	0.9	1.6	1.0	1.3	-0.5
Heart attack	1.3	1.7	2.5	1.6	1.3	-0.9
Allergy	1.0	2.2	2.8	-1.7	-1.4	1.4
Pain all over the body in last month	0.2	0.2	0.3	-0.5	-0.0	0.5
Diabetes (self-reported)	0.1	0.1	0.4	-0.2	-0.6	-0.2
Hayfever/allergic rhinitis (self-reported)	1.7	2.3	3.1	1.2	1.6	-1.8
Medication: Ramipril	0.7	0.9	1.2	1.1	0.6	-1.1
Medication: Simvastatin	1.9	2.8	4.6	1.1	1.6	-2.1
Fluid intelligence score	1.2	2.5	3.1	1.8	1.3	-1.6
Illnesses of siblings	0.2	0.2	0.7	0.1	0.0	-0.8
Neuroticism score	0.1	0.2	0.4	0.6	0.2	-0.4
Weight	0.3	1.2	2.3	1.5	0.2	-1.2
Impedance of arm (right)	1.8	8.3	13.1	-2.9	-1.9	3.6
Arm fat percentage (right)	0.1	0.4	0.9	0.2	-1.0	0.4
Trunk fat-free mass	1.0	5.8	7.2	2.6	1.9	-2.7
Hip circumference	0.9	3.7	6.2	2.5	1.3	-1.8
Time employed in main current job	0.4	0.5	0.7	0.9	0.5	-0.7
Alcohol intake versus 10 years previously	0.1	0.1	0.2	-0.4	0.1	0.3
Father’s age at death	0.2	0.3	0.7	-0.2	-0.8	0.4
Worrier / anxious feelings	0.1	0.2	0.4	0.0	-0.7	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	0.6	-0.3	-0.3
Falls in the last year	0.0	0.1	0.1	0.3	-0.2	0.2
Hair/balding pattern: Pattern 3	0.9	1.3	2.3	-0.5	-1.2	1.5
Number of live births	0.2	0.3	0.4	-0.6	-0.4	0.6
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.4	-1.2	-0.6	1.5
Pulse rate	0.0	0.0	0.1	-0.1	0.0	-0.3
Happiness	0.2	0.3	0.5	-0.2	-0.7	0.6
Noisy workplace	0.0	0.0	0.0	-0.1	-0.2	-0.2
Qualifications: A levels/AS levels or equivalent	0.2	0.4	0.5	0.6	0.7	-0.6
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	0.9	-1.0	-0.8	0.8
Mouth/teeth dental problems: Dentures	0.4	0.7	1.2	-1.1	-0.9	0.4
Asthma	0.7	1.4	1.8	1.2	1.3	-1.0
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.5	1.2	1.1	0.6	0.3
Medication: Cholesterol lowering	4.1	6.3	6.9	2.4	2.5	-2.6
Depression (self-reported)	1.2	1.5	2.2	-0.4	-1.5	1.4
Medication: Lansoprazole	0.1	0.1	0.2	0.5	0.0	0.5
Prospective memory result	0.4	0.5	1.0	-1.0	-0.5	0.5
Lung cancer (father)	4.2	4.9	6.7	-1.8	-2.6	2.2
Illnesses of mother	2.8	3.5	4.8	-2.2	-2.0	1.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	4.3	-1.2	-1.0	2.1
Pulse wave Arterial Stiffness index	0.9	1.0	1.5	1.1	1.2	-0.5
Impedance of arm (left)	2.3	10.9	16.2	-3.4	-2.2	4.0
Arm fat mass (right)	0.1	0.3	0.5	0.7	-0.5	-0.2
Trunk predicted mass	1.1	6.4	8.1	2.7	2.0	-2.8
Standing height	0.1	1.0	1.6	1.0	1.3	-0.7
Length of working week for main job	0.8	0.9	2.0	1.4	0.5	-0.6
Exposure to tobacco smoke at home	0.1	0.1	0.3	0.5	-0.1	0.2
Breastfed as a baby	2.0	2.5	2.7	-1.5	-1.6	1.6
Tense / ‘highly strung’	0.4	0.6	1.6	0.5	0.1	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	0.4	0.1	-0.3
Hair/balding pattern: Pattern 4	0.1	0.3	0.7	0.2	0.8	0.1
Birth weight of first child	0.4	0.8	0.9	-0.9	-1.0	0.8
Peak expiratory flow (PEF)	0.6	1.4	1.7	-1.3	-1.1	1.2
Pulse wave reflection index	0.7	0.9	1.6	1.3	0.9	-0.3
Ever highly irritable/argumentative for 2 days	0.1	0.1	0.1	-0.4	0.4	-0.3
Loud music exposure frequency	1.7	1.8	3.2	1.3	1.8	-0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.6	-0.5	0.7	0.7
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.0	0.5	0.2	-1.0
Blood clot in the leg (DVT)	0.3	0.3	0.8	0.4	-0.1	-0.9
Medication: Paracetamol	1.3	2.2	3.3	1.7	1.8	-0.6
Headache pain in last month	0.7	1.2	1.5	1.1	0.9	-1.2
Medication for cholesterol, blood pressure or diabetes	4.0	6.6	6.9	-2.5	-2.6	2.6
Glaucoma (self-reported)	3.6	4.2	7.1	2.2	2.7	-0.9
Gout (self-reported)	0.6	0.8	1.2	-0.4	-1.1	1.0
Hypothyroidism/myxoedema (self-reported)	0.1	0.3	0.6	-0.3	-0.4	0.8
Medication: Amlodipine	4.5	6.3	6.5	2.5	2.5	-2.5
Medication: Ventolin 100micrograms inhaler	0.6	0.8	1.4	-1.2	-0.6	0.7
Birth weight	0.0	0.1	0.1	0.2	0.3	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	0.5	0.3	-0.5
High blood pressure (siblings)	1.4	2.1	3.0	1.7	1.7	-0.6
Forced vital capacity (FVC), Best measure	0.6	2.3	4.7	-1.3	-0.6	2.2
Body fat percentage	0.2	0.8	1.8	-0.1	-1.3	0.8
Leg fat percentage (right)	0.1	0.5	1.2	0.5	-1.1	0.0
Arm fat-free mass (right)	0.9	4.5	6.2	2.3	1.4	-2.5
Exposure to tobacco smoke outside home	0.9	1.2	2.2	-1.5	-1.1	0.6
Comparative body size at age 10	0.4	1.2	2.1	0.7	1.0	-1.5
Number of full brothers	0.0	0.0	0.1	-0.3	-0.0	0.0
Worry too long after embarrassment	0.1	0.2	0.4	-0.1	-0.3	0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.3	0.5	0.7	-0.1	-0.5
Wheeze or whistling in the chest in last year	0.1	0.1	0.4	0.6	0.0	-0.0
Number of children fathered	1.1	1.2	2.5	1.6	0.8	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	0.8	-0.9	-0.2	0.9
Age at first live birth	0.0	0.1	0.1	-0.4	0.0	0.2
Pulse wave peak to peak time	0.7	0.8	1.2	-1.0	-1.1	0.3
Health satisfaction	1.5	2.0	3.0	1.3	1.1	-1.7
Shortness of breath walking on level ground	0.2	0.3	0.7	-0.0	-0.4	0.8
Qualifications: College or University degree	0.2	0.6	1.1	-1.1	-0.8	0.3
Eye problems/disorders: None of the above	0.1	0.2	0.5	-0.7	-0.0	0.1
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.4	-0.0	-0.2
Emphysema/chronic bronchitis	0.1	0.1	0.1	-0.4	0.2	0.0
Medication for pain relief, constipation, heartburn	0.4	0.6	1.4	-1.2	-0.6	0.1
Neck or shoulder pain in last month	1.1	1.6	2.2	1.5	0.8	-1.4
Medication: Blood pressure	1.9	3.4	3.8	1.7	1.8	-1.9
Angina (self-reported)	3.8	4.9	6.7	2.1	1.9	-2.6
Migraine (self-reported)	0.3	0.3	0.5	0.4	0.7	-0.6
Medication: Ibuprofen	0.4	0.5	1.1	1.1	0.6	0.0
Medication: Allopurinol	0.2	0.3	0.5	-0.1	-0.6	0.7
Medication: Omeprazole	0.3	0.4	0.9	0.0	-1.0	0.4
Medication: Seretide 50 evohaler	0.3	0.4	0.6	-0.6	-0.4	0.7
Mean time to correctly identify matches	0.1	0.3	0.6	-0.5	-0.8	0.0
Heart disease (mother)	2.8	3.4	5.3	1.7	2.3	-1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.5	1.7	3.0	-1.4	-1.7	0.4
Whole body fat mass	0.1	0.3	0.5	0.7	-0.7	-0.0
Leg fat mass (right)	0.2	0.7	1.5	1.2	-0.2	-0.8
Arm predicted mass (right)	0.9	4.4	6.0	2.3	1.4	-2.5
Pulse rate, automated reading	0.2	0.7	0.9	0.8	0.6	-1.0
Alcohol intake frequency.	0.1	0.2	0.5	0.7	0.4	0.1
Comparative height size at age 10	0.1	0.4	0.9	0.6	1.0	-0.2
Number of full sisters	0.1	0.1	0.1	-0.2	-0.1	0.4
Suffer from ‘nerves’	1.7	2.7	3.5	1.9	1.2	-1.8
Overall health rating	1.9	4.1	5.0	2.2	1.8	-2.0
Chest pain or discomfort	0.6	0.9	2.6	1.6	0.3	-0.3
Had major operations	0.1	0.1	0.4	0.6	0.2	-0.1
Age at last live birth	0.7	1.0	1.3	-0.9	-1.1	1.0
Family relationship satisfaction	0.5	0.6	0.8	-0.8	-0.9	0.6
Leg pain on walking	0.5	0.6	0.8	-0.5	-0.9	0.9
Qualifications: NVQ or HND or HNC or equivalent	1.1	1.3	1.7	0.7	1.3	-1.3
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.4	-0.8	-0.7	1.2
Illness, injury, bereavement, stress in last 2 years	0.0	0.1	0.1	-0.0	-0.4	0.0
Medication: Aspirin	1.3	1.7	2.1	1.4	1.3	-1.2
Supplements: Vitamin C	4.6	5.5	5.8	2.3	2.3	-2.4
Knee pain experienced in last month	0.6	1.0	1.5	1.2	0.5	-1.0
Hypertension (Self-reported)	0.3	0.7	1.2	1.1	0.8	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.5	0.7	-0.0	0.3
Illnesses of father: Heart disease	0.5	0.7	1.1	0.9	0.5	-1.1
Illnesses of siblings: Diabetes	3.2	3.9	4.8	-2.2	-2.0	1.7
Smoking status: Previous	0.3	0.4	0.8	-0.6	-0.9	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.5	-0.5	0.2	0.7
Whole body fat-free mass	0.7	4.2	5.2	2.3	1.6	-2.2
Leg fat-free mass (right)	0.3	1.7	2.2	1.5	1.0	-1.3
Arm fat percentage (left)	0.2	0.7	1.4	-0.1	-1.2	0.7
Average weekly red wine intake	0.2	0.2	0.4	0.6	0.3	-0.5
Handedness (chirality/laterality): Left-handed	9.0	10.9	13.0	3.6	2.9	-3.3
Mood swings	0.1	0.3	0.6	0.8	0.3	0.3
Loneliness, isolation	0.3	0.4	0.7	-0.8	-0.8	0.1
Long-standing illness, disability or infirmity	0.1	0.1	0.2	0.5	-0.1	0.4
Ever had bowel cancer screening	0.1	0.1	0.1	-0.2	-0.4	0.1
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.1	-0.7	0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	1.6	-1.3	-1.2	0.5
Friendships satisfaction	0.0	0.0	0.0	0.1	0.1	0.0
Qualifications: nursing, teaching	0.0	0.0	0.1	0.0	-0.2	0.3
Commuting to job workplace: Walk	0.2	0.2	0.6	-0.8	-0.0	0.0
Eye problems/disorders: Cataract	0.4	0.5	0.6	-0.6	-0.7	0.8
Mouth/teeth dental problems: Mouth ulcers	0.0	0.0	0.1	0.2	0.1	0.0
Medication for cholesterol	0.7	1.1	2.0	0.5	1.0	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.1	0.1	0.1	0.3	0.1	0.4
Back pain experienced in last month	0.2	0.3	0.7	0.8	0.1	-0.6
Mineral and other dietary supplements	0.2	0.2	0.3	-0.6	0.2	0.5
Breast cancer (self-reported)	0.7	0.8	1.0	-1.0	-0.8	0.9
Asthma (self-reported)	0.7	1.4	2.2	1.2	1.5	-0.8
Osteoporosis (self-reported)	0.1	0.2	0.3	0.2	-0.4	-0.5
Osteoarthritis (self-reported)	0.9	1.1	1.7	1.3	1.1	-0.7
Medication: Aspirin	1.2	1.5	1.9	1.3	1.1	-1.4
Medication: Gliclazide	0.4	0.4	0.5	-0.7	-0.6	0.6
Illnesses of father: None of the above (group 1)	1.5	1.8	2.2	-1.5	-1.4	1.1
Smoking status: Current	0.1	0.2	0.3	0.5	0.2	-0.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	2.0	-0.9	-0.7	1.4
Whole body water mass	0.8	4.3	5.4	2.3	1.6	-2.2
Leg predicted mass (right)	0.3	1.7	2.3	1.5	1.0	-1.3
Arm fat mass (left)	0.1	0.3	0.4	0.6	-0.6	-0.2
Number of self-reported non-cancer illnesses	1.3	2.3	4.3	2.1	1.0	-1.2
Average weekly champagne plus white wine intake	0.1	0.1	0.1	0.4	-0.1	-0.4
Miserableness	0.1	0.1	0.2	0.4	0.3	-0.2
Guilty feelings	1.3	2.0	2.4	-1.5	-1.2	1.6
Wears glasses or contact lenses	0.4	0.5	0.8	0.9	0.4	-0.6
Ever taken oral contraceptive pill	0.4	0.5	0.9	-0.9	-0.6	0.4
Hearing aid user	1.0	1.1	1.5	1.1	1.2	-0.8
Mother’s age at death	1.4	1.8	2.8	-1.5	-1.7	0.4
Financial situation satisfaction	1.4	1.7	2.3	1.5	1.0	-1.4
Tinnitus: Yes, now most or all of the time	0.5	0.6	1.1	0.9	-0.1	-1.0
Commuting to job workplace: Public transport	0.1	0.1	0.2	0.5	-0.0	-0.2
Eye problems/disorders: Glaucoma	1.0	1.1	1.4	1.0	1.2	1.0
Medication: Blood pressure	1.0	2.0	2.5	-1.1	-1.4	1.6
Pain type(s) experienced in last month: Hip pain	2.8	3.5	6.4	2.5	1.4	-1.5
Supplements: Fish oil (including cod liver oil)	0.4	0.5	1.0	-0.4	-1.0	0.5
High cholesterol (Self-reported)	0.7	1.3	1.5	1.0	1.2	-1.1
Medication: Bendroflumethiazide	0.2	0.2	0.5	-0.3	-0.4	0.7
Medication: Paracetamol	0.6	1.0	1.6	1.2	1.2	0.1
Medication: Lisinopril	0.2	0.2	0.7	-0.8	-0.2	0.2
Medication: Atorvastatin	0.1	0.2	0.3	-0.3	-0.3	0.6
Illnesses of father: High blood pressure	0.3	0.3	0.9	0.3	0.9	-0.1
Alcohol drinker status: Never	3.4	4.0	5.5	2.0	2.3	-1.7
Ever smoked	0.7	1.2	1.4	-1.0	-1.2	1.0
Basal metabolic rate	0.6	3.4	4.5	2.1	1.3	-2.0
Leg fat percentage (left)	0.1	0.5	1.4	0.4	-1.2	0.1
Arm fat-free mass (left)	1.1	5.6	7.7	2.6	1.5	-2.8
Number of operations (self-reported)	0.0	0.1	0.1	-0.0	-0.4	0.1
Average weekly beer plus cider intake	0.0	0.0	0.0	0.1	-0.1	-0.1
Irritability	0.8	1.3	1.5	1.2	1.2	-1.1
Risk taking	0.2	0.3	0.6	-0.8	0.1	0.6
Ever had prostate specific antigen (PSA) test	1.3	1.5	2.5	1.3	1.6	-0.5
Fractured/broken bones in last 5 years	0.1	0.1	0.3	0.0	-0.3	-0.6
Age started oral contraceptive pill	0.5	0.6	1.6	-0.3	-1.3	0.1
Diastolic blood pressure, automated reading	0.0	0.1	0.2	0.3	0.3	-0.4
Ever depressed for a whole week	0.0	0.1	0.1	-0.1	0.1	0.4
Unable to work because of sickness or disability	0.5	0.7	1.1	1.0	0.6	-0.8
Commuting to job workplace: Cycle	1.1	1.3	2.8	-1.7	-0.3	1.0
Myopia	0.8	1.1	1.6	1.1	1.3	-0.8
Vascular/heart problems diagnosed by doctor	0.3	0.8	1.5	-1.2	-0.7	0.7
Cholesterol lowering medication	0.0	0.0	0.1	-0.0	-0.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	0.9	0.1	-1.0	0.4
Pain experienced in last month	0.5	0.8	1.8	-1.3	-0.1	0.8
Supplements: Calcium	1.6	1.8	2.9	1.2	1.1	-1.7
Basal cell carcinoma (self-reported)	0.4	0.4	1.1	-1.0	-0.1	0.5
Heart attack/myocardial infarction (self-reported)	1.0	1.3	2.0	1.4	1.1	-0.8
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	0.6	0.1	-1.1
Heart disease (siblings)	0.0	0.0	0.1	-0.1	0.1	0.3
Alcohol drinker status: Previous	0.1	0.1	0.3	-0.1	-0.5	0.2
Pack years of smoking	0.5	0.8	1.2	0.9	0.6	-1.1
Impedance of whole body	1.4	7.1	9.9	-2.7	-2.0	3.2
Leg fat mass (left)	0.2	0.7	1.4	1.2	-0.3	-0.8
Arm predicted mass (left)	1.2	6.2	8.1	2.8	1.6	-2.8