Best TWAS P=2.51e-17 · Best GWAS P=9.41e-150 conditioned to 3.7e-128
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CUL9 | 0.15 | 0.12 | bslmm | 386 | 0.14 | 3.1e-16 | 5.069 | -5.2 | 1.9e-07 | 0.02 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Male) | RP3-475N16.1 | 0.08 | -0.01 | lasso | 3 | 0.06 | 2.1e-02 | 5.253 | -6.5 | 5.9e-11 | -0.01 | 0.04 | 0.08 | FALSE |
| 3 | GTEx | Cells EBV-transformed lymphocytes | DNPH1 | 0.23 | 0.24 | lasso | 5 | 0.26 | 6.6e-09 | 5.076 | -5.1 | 2.7e-07 | 0.02 | 0.96 | 0.00 | FALSE |
| 4 | GTEx | Cells Transformed fibroblasts | CUL9 | 0.16 | 0.05 | lasso | 6 | 0.04 | 3.9e-04 | 5.808 | 5.7 | 1.5e-08 | 0.00 | 0.22 | 0.07 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | DNPH1 | 0.34 | 0.28 | lasso | 7 | 0.27 | 1.8e-20 | 5.076 | -5.5 | 2.8e-08 | 0.03 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Colon Transverse | DNPH1 | 0.23 | 0.16 | enet | 15 | 0.19 | 3.1e-09 | 5.076 | -5.9 | 2.8e-09 | 0.04 | 0.94 | 0.00 | FALSE |
| 7 | GTEx | Esophagus Mucosa | DNPH1 | 0.37 | 0.34 | lasso | 3 | 0.34 | 1.8e-23 | 5.076 | -5.2 | 2.2e-07 | 0.02 | 1.00 | 0.00 | FALSE |
| 8 | GTEx | Esophagus Muscularis | DNPH1 | 0.18 | 0.01 | enet | 7 | 0.05 | 4.0e-04 | 5.076 | -6.9 | 6.0e-12 | 0.02 | 0.04 | 0.06 | TRUE |
| 9 | GTEx | Liver | CRIP3 | 0.46 | -0.01 | enet | 27 | 0.01 | 2.1e-01 | -0.077 | 5.8 | 5.3e-09 | -0.20 | 0.05 | 0.09 | TRUE |
| 10 | GTEx | Lung | DNPH1 | 0.13 | 0.07 | lasso | 3 | 0.07 | 3.3e-06 | 5.076 | -5.4 | 5.6e-08 | 0.01 | 0.86 | 0.01 | FALSE |
| 11 | GTEx | Muscle Skeletal | DNPH1 | 0.10 | 0.04 | lasso | 3 | 0.03 | 9.7e-04 | 5.076 | -5.8 | 4.8e-09 | -0.01 | 0.53 | 0.10 | FALSE |
| 12 | GTEx | Skin Sun Exposed Lower leg | DNPH1 | 0.15 | 0.08 | lasso | 4 | 0.09 | 8.9e-08 | 5.076 | -5.4 | 8.3e-08 | 0.02 | 0.99 | 0.00 | FALSE |
| 13 | GTEx | Thyroid | RP1-261G23.7 | 0.16 | 0.01 | enet | 30 | 0.01 | 8.7e-02 | -0.154 | -8.3 | 7.5e-17 | 0.29 | 0.04 | 0.35 | TRUE |
| 14 | NTR | Blood | ZNF318 | 0.04 | 0.03 | lasso | 8 | 0.02 | 1.3e-08 | 6.816 | 7.1 | 1.0e-12 | -0.01 | 1.00 | 0.00 | FALSE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | PGC | 0.13 | 0.06 | blup | 520 | 0.06 | 3.2e-08 | -4.020 | 5.7 | 1.1e-08 | 0.03 | 1.00 | 0.00 | TRUE |
| 16 | YFS | Blood | MEA1 | 0.01 | 0.00 | blup | 351 | 0.01 | 4.4e-03 | -1.275 | -5.9 | 4.3e-09 | 0.03 | 0.12 | 0.04 | FALSE |
| 17 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C6orf108 | 0.04 | 0.01 | enet | 3 | 0.02 | 5.9e-03 | 5.076 | -6.6 | 3.0e-11 | 0.00 | 0.02 | 0.83 | FALSE |
| 18 | The Cancer Genome Atlas | Kidney Renal Papillary Cell Carcinoma | CRIP3 | 0.08 | 0.08 | blup | 34 | 0.07 | 1.0e-04 | 7.773 | 8.5 | 2.5e-17 | 0.00 | 0.00 | 0.99 | TRUE |
| 19 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | C6orf108 | 0.10 | 0.11 | lasso | 2 | 0.11 | 4.7e-12 | 5.076 | -5.1 | 3.1e-07 | 0.02 | 0.46 | 0.54 | FALSE |
| 20 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | C6orf108 | 0.05 | 0.03 | lasso | 4 | 0.04 | 8.5e-04 | 5.559 | -5.9 | 3.2e-09 | 0.05 | 0.06 | 0.51 | FALSE |
| 21 | The Cancer Genome Atlas | Rectum Adenocarcinoma | C6orf108 | 0.47 | 0.06 | enet | 24 | 0.13 | 5.0e-04 | 5.253 | -5.6 | 2.3e-08 | -0.01 | 0.01 | 0.35 | FALSE |
| 22 | The Cancer Genome Atlas | Soft Tissue Sarcoma | ZNF318 | 0.04 | 0.02 | blup | 48 | 0.04 | 2.2e-03 | 7.724 | 7.3 | 2.7e-13 | 0.01 | 0.01 | 0.80 | FALSE |
| 23 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | C6orf108 | 0.21 | 0.08 | lasso | 3 | 0.14 | 1.1e-05 | 5.792 | -5.5 | 3.9e-08 | 0.03 | 0.02 | 0.95 | FALSE |