Hub : Genes

CUL9

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.1510 0.0340 3.6e-13 0.121 0.125 0.120 0.136 0.134 1.5e-14 6.1e-15 1.9e-14 3.1e-16 4.8e-16
2 GTEx Cells Transformed fibroblasts 0.1610 0.0490 3.6e-04 0.048 NA 0.030 NA 0.042 1.7e-04 NA 2.6e-03 NA 3.9e-04
3 ROSMAP Brain Pre-frontal Cortex 0.0903 0.0307 6.2e-04 0.046 0.020 0.032 0.033 0.028 1.4e-06 1.2e-03 4.4e-05 4.0e-05 1.4e-04
4 YFS Blood 0.0428 0.0165 3.6e-05 0.002 0.015 0.011 0.013 0.006 7.9e-02 9.8e-06 1.3e-04 2.3e-05 2.5e-03
5 TCGA Kidney Renal Papillary Cell Carcinoma 0.0730 0.0420 8.0e-03 0.043 0.038 0.010 NA 0.019 1.8e-03 2.9e-03 8.3e-02 NA 2.9e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 3.2 5.0 8.7 2.7 -3.0 2.4 -0.4 1.8
Bipolar Disorder or Schizophrenia 4.3 10.6 15.8 3.8 -4.0 3.9 1.0 2.6
Depressed Affect (Nagel 2018) 1.7 3.5 7.5 -2.7 2.6 -1.8 -0.0 0.4
Depression (Nagel 2018) 2.0 3.0 7.2 -2.7 2.1 -1.9 0.1 -0.6
Intelligence (Savage-Jansen 2018) 3.5 10.9 19.5 -4.4 2.4 -4.2 -2.2 -2.7
Neuroticism (Nagel 2018) 2.0 4.6 10.8 -3.3 2.9 -2.0 0.1 0.0
Schizophrenia (2018) 3.0 6.2 9.7 2.7 -2.7 3.1 1.5 2.1
Schizophrenia vs Biploar Disorder 0.1 0.1 0.2 0.4 -0.5 0.3 -0.2 -0.2
Worry (Nagel 2018) 1.1 2.3 5.2 -2.3 1.7 -1.7 0.3 -0.2
Alzheimer’s Disease (in mother) 0.9 1.1 2.1 -0.0 -1.4 -1.0 -1.2 -0.9
Alzheimer’s Disease (in father) 0.3 0.3 0.8 0.4 -0.2 -0.6 -0.6 -0.9
Alzheimer’s Disease (including proxy) 0.8 1.1 2.0 0.2 -1.2 -1.3 -1.4 -0.7
Crohns Disease (2017) 0.2 0.4 1.1 0.1 -0.5 -0.9 -1.0 -0.2
Irritable Bowel Disease (IBD) 0.2 0.5 2.3 -0.2 0.2 -0.6 -1.5 0.0
Ulcerative Colitis (UC) 0.5 0.9 2.7 -0.7 1.0 -0.3 -1.6 0.4
Major Depression (MDD) 0.7 0.8 1.7 -1.3 0.3 -0.4 -1.0 -1.1
Reaction Time 1.2 2.4 5.2 2.0 -1.1 2.3 0.7 1.0
Verbal and Numeric Reasoning (VNR) 2.7 6.5 14.2 -3.0 1.9 -3.8 -1.6 -1.7
Breast Cancer 2.0 4.7 8.0 -2.0 2.8 -2.7 -1.0 -1.7
Ovarian Cancer 0.2 0.3 0.8 -0.3 0.4 -0.9 -0.5 -0.2
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 0.1 0.2 0.7 0.9 -0.3 -0.0 0.0 -0.2
Bipolar Disorder (2011) 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.2 1.6 2.7 0.9 -1.6 1.4 1.1 1.2
Coronary Artery Disease (CAD) 2.0 2.4 6.7 -2.6 2.1 -0.5 -0.8 -0.2
Crohns Disease (2012) 0.6 1.0 2.2 1.2 -1.5 -0.7 0.9 -0.4
Mean Putamen Volume 0.5 0.5 1.1 0.9 -1.0 0.7 0.4 0.3
Fasting Glucose 1.1 1.4 3.3 0.2 -1.8 -0.7 1.7 0.0
HbA1C 0.8 0.8 3.6 -0.1 -0.4 -0.4 1.9 0.4
HDL Cholesterol 0.4 0.6 1.8 -0.3 -0.8 0.4 -1.4 -0.5
LDL Cholesterol 0.5 0.7 3.2 0.3 -0.6 0.0 1.8 0.3
Lupus 4.5 6.9 11.0 1.6 -2.7 3.0 3.3 2.1
Neuroticism (2016) 0.2 0.3 0.6 -0.7 0.2 -0.4 0.8 0.3
Primary Biliary Cirrhosis 0.4 0.5 1.9 0.2 0.6 -0.6 -1.4 -0.2
Rheumatoid Arthritis 0.6 0.8 1.8 -0.8 0.6 -0.5 -1.3 -1.0
Schizophrenia (2014) 3.9 8.5 14.1 3.8 -3.5 3.4 0.6 2.1
Triglycerides 0.2 0.4 0.8 0.4 -0.9 -0.3 0.7 -0.6
Type 2 Diabetes (T2D) (2012) 0.9 1.1 2.3 -0.7 -0.8 -1.5 1.3 0.3
Ulcerative Colitis 0.1 0.2 0.6 0.0 -0.4 -0.3 -0.8 -0.1
Blood Eosinophil Count 0.4 3.0 7.3 2.4 -2.7 0.2 -0.1 1.3
Blood Platelet Count 0.9 10.2 33.6 -2.6 -0.3 -1.2 -5.8 -3.0
Blood Red Count 0.8 7.7 17.6 4.2 -2.0 3.0 2.4 1.4
Blood White Count 0.1 0.5 1.9 0.3 -1.4 0.1 -0.1 0.5
Heel T-Score 0.3 2.2 4.5 -0.6 2.0 -0.5 2.1 1.4
BMI 0.5 2.7 6.5 0.7 -0.1 -1.2 2.3 2.5
Height 1.1 21.8 60.2 7.8 -3.5 4.7 0.3 3.8
Waist Hip Ratio (WHR) 3.1 13.8 32.0 -5.2 5.7 -2.7 1.1 -1.2
Systolic Blood Pressure 0.7 3.3 11.8 -1.3 1.2 1.1 3.4 0.5
Smoking Status 0.4 0.9 3.3 -0.3 0.5 -0.4 1.8 0.8
Allergy or Eczema 0.4 1.1 2.0 -1.4 -0.0 -1.4 -0.5 -1.1
Cardiovascular Disease 1.2 4.1 15.5 -0.7 2.0 -0.2 3.9 0.8
Hypothyroidism (self reported) 0.4 0.9 2.2 1.5 0.3 0.4 1.3 0.5
Respiratory disease 2.7 6.1 13.2 -3.6 2.2 -2.6 -0.9 -2.2
Type 2 Diabetes (T2D) (2018) 0.5 1.0 4.0 -0.3 0.8 -0.1 2.0 -0.5
Lung FEV1/FVC ratio 0.1 0.3 0.4 -0.4 -0.4 -0.7 -0.6 -0.7
Lung FVC 1.4 7.0 18.6 4.3 -2.3 3.2 0.9 0.4
Neuroticism 4.0 9.8 18.8 -4.3 4.2 -3.1 -1.1 -1.0
Chronotype (morning person) 0.5 1.2 1.9 -1.4 1.3 -1.0 0.8 0.8
Hair Pigment 0.1 2.3 4.5 1.5 -2.1 1.9 0.1 0.9
Tanning 0.2 2.6 3.9 -1.4 1.4 -2.0 -1.9 -1.1
Hand grip strength (left) 0.4 1.0 2.8 1.7 -0.8 0.4 0.3 -1.0
Number of treatments/medications taken 0.4 0.8 2.3 -0.6 1.5 0.3 0.5 0.9
Average weekly spirits intake 0.9 1.2 3.4 -0.7 0.1 -1.8 -1.4 -0.0
Sensitivity / hurt feelings 1.6 2.7 7.2 -2.3 2.7 -0.1 -0.8 -0.4
Frequency of depressed mood in last 2 weeks 4.3 6.0 11.3 -3.2 3.4 -1.6 -1.6 -1.9
Hearing difficulty/problems: Yes 3.7 5.6 17.0 -0.9 1.3 -0.6 -4.1 -2.9
Relative age of first facial hair 2.9 6.0 7.8 2.8 -2.4 2.7 1.7 2.5
Other serious medical condition/disability diagnosed by doctor 1.1 1.4 2.5 -1.3 1.6 -0.8 -0.8 1.2
Ever used hormone-replacement therapy (HRT) 1.3 1.6 4.6 -1.4 2.1 -1.2 -0.1 0.1
Ever had hysterectomy (womb removed) 0.6 0.7 1.5 0.3 0.7 1.1 0.5 1.2
Systolic blood pressure, automated reading 0.3 0.9 3.3 -1.0 0.2 0.3 1.8 -0.4
Eye problems/disorders: Diabetes related eye disease 1.3 1.5 2.8 0.3 -1.0 1.4 1.7 1.2
Angina 0.5 0.6 1.9 -0.4 -0.5 0.5 0.8 1.4
Medication for hormone replacement therapy 2.7 3.0 6.0 -1.4 2.4 -0.9 -2.4 -0.9
Vitamin and mineral supplements 1.2 1.6 2.5 1.5 0.3 1.1 1.6 1.5
Supplements: Zinc 2.2 2.4 8.2 -0.7 -0.4 -1.5 -2.9 -1.0
Medication: Co-codamol 0.2 0.2 0.5 0.4 0.1 -0.7 -0.1 0.6
Medication: Metformin 0.3 0.4 1.3 -0.2 1.2 -0.1 0.5 -0.5
Diabetes (father) 0.6 0.8 1.7 -1.3 0.5 -0.5 -1.0 -0.9
Diabetes (mother) 0.6 0.8 1.5 0.9 -0.6 0.0 1.1 -1.2
Severe depression (siblings) 1.3 1.4 3.3 -1.8 -0.3 -0.8 -1.3 -1.2
Pack years adult smoking proportion 1.3 2.0 5.1 1.1 -1.0 0.5 2.3 1.7
Impedance of leg (right) 0.2 0.9 3.5 -0.1 -0.2 1.9 -0.8 -0.6
Leg fat-free mass (left) 0.9 4.7 12.9 3.6 -1.9 0.3 1.0 2.4
Trunk fat percentage 0.2 0.9 2.6 0.7 -1.2 0.1 0.4 1.6
Hand grip strength (right) 0.4 1.0 2.8 1.7 -1.2 0.1 -0.7 -0.7
Townsend deprivation index at recruitment 0.7 1.0 3.4 -0.3 -1.9 0.5 -0.8 -0.9
Current tobacco smoking 0.7 1.1 2.3 -0.8 0.5 -1.5 1.4 -0.2
Average weekly fortified wine intake 0.4 0.5 1.2 -0.5 0.6 -0.8 0.0 -1.1
Maternal smoking around birth 0.3 0.4 0.6 -0.7 0.7 0.8 -0.6 0.2
Fed-up feelings 1.6 2.9 6.8 -2.3 2.6 -1.2 -0.6 -0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 0.3 0.5 0.7 -0.8 0.5 -0.7 0.8 0.5
Relative age voice broke 2.5 3.9 5.3 1.9 -1.9 2.1 2.3 1.5
Taking other prescription medications 0.9 1.4 5.2 -0.1 0.1 -0.1 1.3 2.3
Age when periods started (menarche) 0.9 2.1 7.2 2.7 -1.2 1.3 0.0 -0.4
Bilateral oophorectomy (both ovaries removed) 0.5 0.5 1.2 0.6 -0.6 1.1 0.6 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.2 0.4 0.6 -0.8 0.6 -0.8 0.4 0.3
Tinnitus: Yes, but not now, but have in the past 1.2 1.2 2.9 -1.4 1.7 -0.8 -0.4 -0.7
Qualifications: CSEs or equivalent 2.0 2.7 4.9 -1.8 1.6 -0.8 -2.2 -1.5
Serious illness, injury or assault to yourself 4.0 4.9 9.1 -2.4 0.8 -2.5 -3.0 -1.6
High blood pressure 0.9 2.5 5.3 -1.5 2.3 -0.4 2.2 -0.2
Hayfever, allergic rhinitis or eczema 0.4 0.8 1.6 -0.9 -0.1 -1.1 -1.3 -0.7
Multivitamins +/- minerals 0.4 0.5 2.0 0.5 -1.4 -0.1 -0.1 -0.6
Stomach or abdominal pain in last month 0.9 1.1 4.2 -2.0 1.2 -0.2 0.0 0.2
Supplements: Glucosamine 2.3 3.0 4.9 -1.3 2.2 -1.5 -2.1 -1.2
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 2.7 0.4 -0.5 0.1 1.1 1.6
Medication: Atenolol 1.0 1.2 2.9 -1.0 1.7 -0.5 1.0 1.0
Medication: Levothyroxine sodium 1.1 1.9 5.7 2.4 0.2 0.4 1.7 1.0
Sitting height 0.6 4.3 15.0 3.9 -1.5 1.1 0.8 1.6
Chronic bronchitis/emphysema (father) 0.8 1.0 2.1 -1.2 0.3 -1.4 -1.2 -0.3
High blood pressure (mother) 1.1 1.5 3.5 -0.1 1.3 0.8 1.9 1.3
Body mass index (BMI) 0.2 0.8 1.8 0.5 -0.6 -1.0 0.8 1.3
Impedance of leg (left) 0.2 0.9 3.1 -0.7 0.1 1.8 -0.6 -0.6
Leg predicted mass (left) 0.9 4.7 13.0 3.6 -2.0 0.3 1.0 2.3
Trunk fat mass 0.5 1.9 4.2 1.8 -1.4 0.3 0.5 2.1
Waist circumference 0.2 0.7 1.5 0.2 0.6 -0.7 1.1 1.2
Number of incorrect matches in round 6.6 11.0 19.1 4.4 -3.3 3.7 2.7 1.9
Past tobacco smoking 1.8 3.2 5.5 -1.8 0.7 -1.9 -1.9 -2.4
Alcohol usually taken with meals 0.6 1.0 2.2 1.0 -0.3 1.5 1.4 0.1
Nervous feelings 0.3 0.6 1.7 -0.5 1.3 -0.6 -0.1 -0.9
Frequency of tenseness / restlessness in last 2 weeks 1.1 1.7 4.2 -1.4 2.1 -0.8 -0.2 -1.3
Hearing difficulty/problems with background noise 2.4 3.9 9.9 0.2 0.6 -0.4 -3.0 -3.1
Hair/balding pattern: Pattern 2 2.5 3.2 4.8 2.1 -2.2 1.1 2.1 1.2
Had menopause 0.2 0.3 0.6 -0.5 -0.1 -0.8 -0.6 0.3
Had other major operations 0.4 0.5 2.0 -0.0 -1.4 -0.7 0.2 -0.0
Forced vital capacity (FVC) 2.3 8.9 25.1 5.0 -2.8 2.8 1.7 0.7
Heel bone mineral density (BMD) T-score, automated (right) 0.1 0.3 0.8 -0.1 0.3 0.2 0.9 0.6
Ever unenthusiastic/disinterested for a whole week 0.3 0.4 0.9 -0.0 -0.4 -0.5 0.8 1.0
Qualifications: None of the above 0.3 0.6 0.7 -0.6 0.6 -0.7 -0.8 -0.9
Financial difficulties in last 2 years 1.3 1.7 2.8 -1.7 1.6 -1.1 -0.9 -1.0
Mouth/teeth dental problems 0.2 0.3 1.0 0.0 -0.5 0.3 -1.0 -0.2
Heart attack 0.6 0.8 3.3 0.7 -0.2 0.5 0.3 1.8
Allergy 1.0 2.2 3.3 1.8 -0.4 1.8 1.3 1.7
Pain all over the body in last month 0.4 0.4 1.8 -1.3 0.2 -0.1 0.3 -0.1
Diabetes (self-reported) 0.4 0.5 2.6 -0.2 0.3 -0.1 1.6 -0.0
Hayfever/allergic rhinitis (self-reported) 0.6 0.8 2.9 -0.4 -1.7 -0.8 0.6 -0.1
Medication: Ramipril 0.2 0.3 1.0 0.2 -0.5 -1.0 0.5 0.1
Medication: Simvastatin 1.2 1.8 4.6 -0.7 1.6 0.0 2.1 -1.2
Fluid intelligence score 2.4 4.9 8.7 -2.8 2.2 -2.9 -0.8 -1.5
Illnesses of siblings 0.8 1.1 1.6 1.3 -1.3 -0.8 -1.3 0.4
Neuroticism score 1.9 3.9 10.7 -2.6 3.3 -1.4 -0.0 -0.3
Weight 0.7 3.6 9.0 3.0 -1.5 0.5 0.9 2.4
Impedance of arm (right) 0.1 0.5 1.2 -1.0 -0.3 0.6 -1.1 0.1
Arm fat percentage (right) 0.2 0.6 1.9 0.0 -0.8 -0.8 0.0 1.4
Trunk fat-free mass 1.1 6.6 21.3 4.6 -1.6 1.4 1.0 2.5
Hip circumference 0.7 3.1 7.7 2.8 -1.9 0.6 -0.5 1.9
Time employed in main current job 3.2 3.7 4.4 -1.9 1.6 -2.1 -2.1 -2.0
Alcohol intake versus 10 years previously 0.2 0.3 0.7 -0.3 -0.8 -0.2 0.8 -0.1
Father’s age at death 0.3 0.4 1.0 1.0 0.3 0.1 -0.9 -0.2
Worrier / anxious feelings 5.0 9.5 19.7 -4.4 4.2 -2.5 -0.4 -2.0
Frequency of tiredness / lethargy in last 2 weeks 1.7 2.8 6.2 -2.5 1.3 -1.5 -1.5 -1.2
Falls in the last year 4.0 5.4 11.9 -3.0 3.5 -2.5 -0.1 -0.6
Hair/balding pattern: Pattern 3 1.3 1.9 3.2 -0.6 1.8 0.8 -1.8 -1.5
Number of live births 2.2 3.1 6.7 2.6 -1.2 2.1 0.8 1.5
Forced expiratory volume in 1-second (FEV1) 1.4 4.6 15.6 4.0 -1.9 1.6 1.1 -0.3
Pulse rate 1.1 1.8 4.8 -0.7 -0.1 -1.8 -0.9 -2.2
Happiness 0.4 0.5 1.2 0.1 -1.1 0.4 1.0 0.1
Noisy workplace 0.8 1.0 1.5 1.2 -0.8 1.0 1.0 0.9
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.6 -0.6 0.2 -0.2 -0.8 -0.8
Serious illness, injury or assault of a close relative in last 2 years 2.7 3.2 6.0 -1.8 2.4 -1.9 -0.5 -1.7
Mouth/teeth dental problems: Dentures 0.4 0.6 1.7 0.2 -0.1 1.3 1.2 0.1
Asthma 0.9 1.7 2.7 -1.6 1.2 -1.6 0.3 -1.4
Medication: Ibuprofen (e.g. Nurofen) 0.5 0.6 1.9 -0.1 -0.5 -1.4 -0.8 -0.3
Medication: Cholesterol lowering 0.5 0.7 2.1 0.9 0.3 0.7 1.4 0.4
Depression (self-reported) 0.6 0.7 2.3 -0.7 0.3 -0.6 -0.5 1.5
Medication: Lansoprazole 0.8 1.0 2.9 -1.7 0.9 -0.6 0.2 -0.8
Prospective memory result 2.4 2.9 4.9 2.2 -2.2 1.6 0.9 1.2
Lung cancer (father) 0.7 0.8 1.6 0.9 -0.9 0.3 1.3 0.8
Illnesses of mother 0.7 0.9 2.7 -0.9 0.1 -0.5 -1.6 -0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.6 2.0 6.3 2.5 -1.5 0.5 -0.7 -0.7
Pulse wave Arterial Stiffness index 0.3 0.3 0.8 0.1 -0.6 -0.6 0.9 0.2
Impedance of arm (left) 0.2 1.0 2.9 -1.7 0.1 0.1 -1.4 -0.6
Arm fat mass (right) 0.4 1.6 3.7 1.4 -1.4 -0.3 0.6 1.9
Trunk predicted mass 1.1 6.5 21.1 4.6 -1.7 1.3 1.1 2.5
Standing height 1.3 12.7 36.2 6.0 -2.4 3.7 0.4 2.8
Length of working week for main job 0.6 0.6 2.9 0.4 -0.2 -0.1 0.1 1.7
Exposure to tobacco smoke at home 1.0 1.2 3.0 -1.7 0.5 -0.9 -1.2 -0.6
Breastfed as a baby 0.9 1.1 3.2 1.8 0.4 1.4 0.2 0.2
Tense / ‘highly strung’ 1.2 1.9 7.0 -1.3 0.9 -2.6 -0.0 0.4
Seen doctor (GP) for nerves, anxiety, tension or depression 0.8 1.2 2.4 -1.6 1.4 -1.2 -0.3 -0.4
Hair/balding pattern: Pattern 4 1.7 4.2 10.6 3.2 -1.2 1.9 1.6 1.6
Birth weight of first child 1.8 3.4 6.0 1.9 -2.4 0.6 1.8 1.9
Peak expiratory flow (PEF) 0.3 0.7 2.3 1.5 0.1 0.4 1.0 -0.1
Pulse wave reflection index 1.0 1.2 2.9 1.0 -1.7 0.1 0.6 1.4
Ever highly irritable/argumentative for 2 days 2.4 2.9 7.4 -2.5 0.3 -2.7 -0.7 0.1
Loud music exposure frequency 0.9 1.0 3.8 -0.8 0.5 -0.5 -0.3 -1.9
Qualifications: O levels/GCSEs or equivalent 1.2 1.8 3.4 -1.6 1.2 -1.0 -1.8 -1.0
Mouth/teeth dental problems: Bleeding gums 1.6 2.0 4.1 -1.5 1.1 -2.0 -0.7 -1.4
Blood clot in the leg (DVT) 2.1 2.8 3.9 -2.0 1.4 -1.8 -1.6 -1.5
Medication: Paracetamol 0.5 0.8 2.1 0.0 -1.4 0.9 -0.4 1.0
Headache pain in last month 0.3 0.6 1.2 -0.3 1.1 -0.4 -1.1 0.6
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.8 -0.8 -0.7 -0.7 -1.3 0.5
Glaucoma (self-reported) 0.4 0.5 1.2 -0.8 -0.5 0.5 -1.1 0.3
Gout (self-reported) 1.5 2.1 9.4 -0.7 -0.2 -0.8 3.1 0.2
Hypothyroidism/myxoedema (self-reported) 0.6 1.2 3.4 1.9 0.4 0.7 1.2 0.6
Medication: Amlodipine 1.5 2.1 4.5 -0.9 1.7 1.2 2.1 1.1
Medication: Ventolin 100micrograms inhaler 0.0 0.0 0.1 0.0 0.4 -0.0 -0.0 -0.2
Birth weight 2.9 6.3 8.5 2.9 -2.7 2.5 2.8 0.9
Chronic bronchitis/emphysema (mother) 0.4 0.4 1.2 0.2 0.1 0.2 1.1 0.9
High blood pressure (siblings) 1.1 1.6 3.2 -1.6 1.8 1.2 0.7 -0.6
Forced vital capacity (FVC), Best measure 1.0 3.5 11.2 3.4 -2.2 1.2 0.1 0.1
Body fat percentage 0.1 0.5 1.6 0.3 -0.9 -0.2 0.3 1.2
Leg fat percentage (right) 0.1 0.3 0.5 0.7 -0.7 -0.0 0.3 0.7
Arm fat-free mass (right) 0.9 4.5 14.7 3.8 -1.5 0.8 1.0 2.0
Exposure to tobacco smoke outside home 1.1 1.5 2.7 -1.6 1.2 -1.5 0.4 -1.0
Comparative body size at age 10 3.0 8.4 13.2 -3.4 3.6 -3.3 -1.2 -2.1
Number of full brothers 0.3 0.4 0.7 -0.8 0.5 -0.7 -0.2 -0.5
Worry too long after embarrassment 1.0 1.7 5.7 -1.4 2.4 -0.9 -0.3 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.9 2.5 3.8 -2.0 1.5 -1.8 -1.5 -0.8
Wheeze or whistling in the chest in last year 0.9 1.6 3.5 -1.1 1.4 -1.1 1.9 0.3
Number of children fathered 1.2 1.4 5.0 0.4 1.3 0.4 2.2 -0.0
Reason for reducing amount of alcohol drunk: Health precaution 1.0 1.2 4.8 0.8 -0.3 0.6 2.2 -0.0
Age at first live birth 0.3 0.6 1.5 1.2 -0.8 0.7 0.5 -0.0
Pulse wave peak to peak time 0.2 0.3 0.6 0.3 0.5 0.7 -0.8 0.1
Health satisfaction 3.6 4.7 6.6 -2.4 1.7 -2.5 -2.6 -1.4
Shortness of breath walking on level ground 0.7 0.8 2.2 -1.2 0.2 -0.6 -1.5 -0.3
Qualifications: College or University degree 0.4 1.4 2.5 1.6 -1.5 0.1 1.5 0.5
Eye problems/disorders: None of the above 0.7 0.8 2.1 -0.4 1.4 -0.9 -1.0 -0.3
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.1 0.8 -1.0 -0.2 -0.3 0.1
Emphysema/chronic bronchitis 0.2 0.2 0.5 0.3 -0.7 0.6 0.2 0.4
Medication for pain relief, constipation, heartburn 0.1 0.1 0.4 -0.1 0.1 -0.1 0.3 -0.7
Neck or shoulder pain in last month 2.9 4.1 8.3 -2.9 2.4 -1.9 -1.4 -0.9
Medication: Blood pressure 0.9 1.5 4.3 1.0 0.6 1.2 2.1 0.9
Angina (self-reported) 0.5 0.7 1.9 -0.3 -0.6 0.6 0.8 1.4
Migraine (self-reported) 0.6 0.7 3.1 0.3 -0.3 0.5 0.3 -1.8
Medication: Ibuprofen 0.5 0.6 1.7 -0.4 -0.5 -1.3 -0.9 -0.4
Medication: Allopurinol 1.0 1.3 2.5 -1.6 0.4 -1.3 1.4 -0.6
Medication: Omeprazole 0.3 0.4 0.8 0.1 0.7 0.9 -0.5 0.6
Medication: Seretide 50 evohaler 0.3 0.3 0.4 -0.6 0.6 -0.6 0.6 -0.5
Mean time to correctly identify matches 1.0 1.9 4.3 1.9 -0.6 2.1 0.8 0.8
Heart disease (mother) 0.9 1.1 3.2 -0.4 -0.9 -0.2 1.8 1.2
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.1 2.5 6.2 -1.7 0.8 -1.5 0.7 -2.5
Whole body fat mass 0.4 1.6 3.1 1.7 -1.3 0.2 0.5 1.8
Leg fat mass (right) 0.5 1.9 3.5 1.9 -1.4 0.1 0.8 1.8
Arm predicted mass (right) 1.0 5.0 15.7 4.0 -1.7 1.0 1.1 2.1
Pulse rate, automated reading 0.3 1.1 3.6 0.4 -1.0 -0.8 0.1 -1.9
Alcohol intake frequency. 0.6 1.5 2.6 0.9 -1.3 1.0 1.6 1.0
Comparative height size at age 10 0.6 3.2 8.6 2.9 -0.6 1.6 0.7 2.0
Number of full sisters 0.5 0.6 1.4 0.7 -0.6 -0.1 0.8 -1.2
Suffer from ‘nerves’ 0.8 1.2 2.9 -1.4 1.7 -0.9 -0.5 -0.4
Overall health rating 1.7 3.7 8.5 -2.9 1.8 -1.8 -1.8 -0.7
Chest pain or discomfort 1.6 2.3 6.0 -2.2 2.4 0.1 -0.8 -0.0
Had major operations 0.5 0.6 1.4 -1.2 1.0 0.6 0.5 -0.2
Age at last live birth 0.9 1.3 4.4 2.1 -0.5 1.3 0.5 -0.2
Family relationship satisfaction 0.6 0.7 2.5 -0.4 -1.6 -0.8 0.6 -0.2
Leg pain on walking 0.5 0.6 1.6 0.7 -0.5 -0.0 0.7 1.3
Qualifications: NVQ or HND or HNC or equivalent 4.3 5.2 10.3 3.2 -1.8 2.4 1.6 2.0
Commuting to job workplace: Car/motor vehicle 0.3 0.4 1.2 -0.4 0.1 0.3 1.1 0.6
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 1.7 1.3 -0.9 1.1 1.0 -0.4
Medication: Aspirin 0.7 0.9 2.4 -0.1 1.6 0.4 1.3 0.2
Supplements: Vitamin C 2.9 3.4 7.5 -1.7 0.9 -2.2 -2.7 -1.1
Knee pain experienced in last month 0.2 0.3 0.7 0.1 0.6 -0.2 0.6 0.8
Hypertension (Self-reported) 0.8 2.2 5.2 -1.3 2.0 -0.0 2.3 0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.4 -0.0 1.2 0.5 -0.2 0.3
Illnesses of father: Heart disease 0.1 0.1 0.5 -0.7 0.0 0.4 -0.1 -0.1
Illnesses of siblings: Diabetes 1.7 2.1 5.9 -2.4 1.0 -1.8 -0.1 -0.4
Smoking status: Previous 3.8 5.6 9.7 2.5 -1.0 2.7 2.0 3.1
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.2 2.1 -1.5 0.9 0.2 1.1
Whole body fat-free mass 1.0 6.0 18.4 4.3 -1.8 1.0 1.1 2.5
Leg fat-free mass (right) 0.8 4.3 11.4 3.4 -1.8 0.4 1.1 2.3
Arm fat percentage (left) 0.1 0.6 1.3 -0.4 -0.6 -1.0 0.0 1.1
Average weekly red wine intake 1.1 1.6 4.3 1.6 -2.1 0.8 0.8 -0.2
Handedness (chirality/laterality): Left-handed 0.2 0.2 0.5 0.5 -0.3 0.4 0.2 0.7
Mood swings 0.4 0.8 1.8 -0.7 0.9 -0.2 1.3 0.9
Loneliness, isolation 0.5 0.7 1.9 -0.9 1.4 -0.6 -0.7 0.3
Long-standing illness, disability or infirmity 1.0 1.5 4.2 -1.1 0.9 -2.1 -0.8 -0.7
Ever had bowel cancer screening 0.1 0.1 0.3 -0.1 0.5 0.3 0.1 0.5
Diabetes diagnosed by doctor 0.4 0.6 2.4 -0.2 0.6 -0.1 1.5 -0.6
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 4.4 1.0 -0.2 0.9 2.1 1.2
Friendships satisfaction 1.0 1.3 4.5 0.8 -2.1 0.2 1.1 0.4
Qualifications: nursing, teaching 0.3 0.4 1.2 0.6 -1.1 -0.2 0.6 0.4
Commuting to job workplace: Walk 0.2 0.2 0.6 0.1 0.8 -0.4 -0.4 0.3
Eye problems/disorders: Cataract 0.7 0.9 1.5 -1.2 0.7 -1.2 -0.1 -1.0
Mouth/teeth dental problems: Mouth ulcers 1.1 1.7 3.2 -1.1 1.8 -0.9 -1.8 -0.5
Medication for cholesterol 1.6 2.4 6.7 2.0 -2.6 0.9 -0.8 0.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.5 2.1 -1.4 0.3 -0.3 0.2 0.6
Back pain experienced in last month 1.7 2.5 5.5 -1.9 2.4 -0.9 1.1 1.2
Mineral and other dietary supplements 0.6 0.8 2.2 -0.4 -0.7 -0.7 1.5 0.8
Breast cancer (self-reported) 0.9 1.1 2.8 -0.4 -1.0 0.6 1.0 1.7
Asthma (self-reported) 1.0 2.0 3.7 -1.9 1.3 -1.7 0.3 -1.4
Osteoporosis (self-reported) 0.7 0.9 2.6 -0.7 0.5 -0.8 -0.9 -1.6
Osteoarthritis (self-reported) 0.3 0.4 1.0 0.3 -1.0 -0.7 0.4 0.7
Medication: Aspirin 0.7 1.0 2.7 0.2 1.6 0.5 1.3 0.3
Medication: Gliclazide 0.3 0.4 1.1 -0.4 1.1 -0.3 0.7 -0.2
Illnesses of father: None of the above (group 1) 0.2 0.2 0.8 0.4 0.0 -0.2 -0.9 0.4
Smoking status: Current 0.6 0.9 2.2 -0.7 0.5 -1.3 1.5 -0.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.6 5.0 2.2 -1.2 0.9 0.9 0.4
Whole body water mass 1.0 5.7 17.3 4.2 -1.8 0.9 1.0 2.4
Leg predicted mass (right) 0.9 4.7 12.3 3.5 -1.9 0.5 1.2 2.4
Arm fat mass (left) 0.3 1.1 2.7 1.2 -1.0 -0.4 0.6 1.6
Number of self-reported non-cancer illnesses 0.8 1.5 2.8 -1.0 1.7 -0.6 1.7 0.6
Average weekly champagne plus white wine intake 0.4 0.5 1.2 -0.5 -0.5 -0.0 -0.8 -1.1
Miserableness 1.6 2.7 5.9 -2.4 2.1 -1.6 -0.7 -0.6
Guilty feelings 1.8 2.7 5.8 -2.1 2.4 -1.5 -0.9 -0.4
Wears glasses or contact lenses 1.1 1.2 2.5 0.9 -1.4 1.6 0.8 0.6
Ever taken oral contraceptive pill 0.3 0.3 0.7 0.8 -0.6 0.3 0.6 0.0
Hearing aid user 1.0 1.1 2.2 1.5 -0.9 1.4 -0.6 0.6
Mother’s age at death 0.7 0.8 2.0 0.9 -0.8 0.5 -0.7 -1.4
Financial situation satisfaction 4.9 6.1 11.1 -2.5 1.8 -3.3 -2.2 -2.3
Tinnitus: Yes, now most or all of the time 2.5 2.9 6.7 -1.4 0.5 -1.0 -2.6 -2.2
Commuting to job workplace: Public transport 0.9 1.1 2.5 -1.3 0.2 -0.2 -1.6 -1.2
Eye problems/disorders: Glaucoma 0.5 0.6 1.1 0.2 -1.1 1.1 0.3 0.7
Medication: Blood pressure 1.9 3.7 7.1 -2.6 2.7 -1.6 1.3 -0.1
Pain type(s) experienced in last month: Hip pain 1.0 1.2 2.2 -1.1 1.5 -1.1 -0.8 0.9
Supplements: Fish oil (including cod liver oil) 0.4 0.5 0.8 0.7 0.8 0.9 -0.7 0.2
High cholesterol (Self-reported) 0.8 1.4 2.5 -0.7 1.6 0.5 1.4 1.4
Medication: Bendroflumethiazide 1.0 1.6 5.1 -0.3 1.4 -0.7 2.3 0.4
Medication: Paracetamol 0.6 0.9 2.3 0.1 -1.5 0.6 -0.2 1.4
Medication: Lisinopril 0.4 0.5 0.9 0.0 0.9 1.0 0.2 0.9
Medication: Atorvastatin 0.5 0.7 2.6 -0.8 0.2 -0.0 -0.2 1.6
Illnesses of father: High blood pressure 1.4 1.8 4.8 1.1 -1.0 1.3 2.2 0.2
Alcohol drinker status: Never 0.4 0.4 2.0 0.2 -1.4 -0.2 0.1 -0.1
Ever smoked 0.3 0.5 1.1 0.3 0.5 0.8 0.4 1.0
Basal metabolic rate 1.1 6.1 17.8 4.2 -2.0 1.0 1.2 2.6
Leg fat percentage (left) 0.1 0.2 0.6 0.2 -0.4 -0.3 0.3 0.7
Arm fat-free mass (left) 1.2 6.2 19.2 4.4 -1.9 1.1 1.4 2.2
Number of operations (self-reported) 0.3 0.5 0.8 -0.8 -0.9 -0.5 0.7 0.3
Average weekly beer plus cider intake 0.3 0.5 1.6 -0.6 0.1 -1.3 -0.7 -0.1
Irritability 1.3 2.1 3.7 -1.9 1.7 -1.6 0.2 -1.3
Risk taking 0.6 0.8 2.4 -0.9 0.6 0.3 -0.6 1.6
Ever had prostate specific antigen (PSA) test 0.8 0.9 1.6 -1.0 0.8 -1.3 -0.6 -1.0
Fractured/broken bones in last 5 years 0.4 0.5 0.9 -0.6 0.2 -0.8 1.0 -0.8
Age started oral contraceptive pill 1.4 1.7 3.9 2.0 -0.8 1.2 1.4 0.8
Diastolic blood pressure, automated reading 0.5 1.5 3.9 0.9 -1.4 0.1 2.0 1.0
Ever depressed for a whole week 0.4 0.5 1.2 -1.1 0.7 -0.2 0.7 -0.4
Unable to work because of sickness or disability 1.1 1.4 2.4 -1.5 0.7 -1.6 -1.2 -0.6
Commuting to job workplace: Cycle 1.5 1.9 5.2 1.4 -0.9 1.1 2.3 0.2
Myopia 0.4 0.6 2.5 -0.3 -0.5 0.5 1.6 0.1
Vascular/heart problems diagnosed by doctor 1.1 2.9 6.1 1.7 -2.3 0.5 -2.5 -0.1
Cholesterol lowering medication 1.4 2.0 4.0 -1.5 1.9 -0.5 2.0 0.3
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.4 -0.4 0.6 0.3 -0.6 0.3
Pain experienced in last month 1.3 2.2 6.1 1.9 -2.5 0.8 0.6 -0.3
Supplements: Calcium 0.5 0.6 1.0 -0.6 -0.1 -0.9 -0.7 -1.0
Basal cell carcinoma (self-reported) 1.1 1.3 2.2 1.2 -0.7 0.9 1.3 1.5
Heart attack/myocardial infarction (self-reported) 0.8 1.0 3.6 0.9 -0.2 0.6 0.3 1.9
Deep venous thrombosis (DVT) (self-reported) 2.4 3.1 4.4 -2.1 1.4 -1.9 -1.6 -1.7
Heart disease (siblings) 1.3 1.6 5.8 0.9 -0.2 1.2 2.4 0.3
Alcohol drinker status: Previous 0.3 0.4 1.1 0.8 0.1 0.0 1.0 0.2
Pack years of smoking 1.5 2.3 5.3 1.3 -0.8 0.8 2.3 1.8
Impedance of whole body 0.1 0.7 1.1 -1.0 -0.2 1.1 -0.9 -0.7
Leg fat mass (left) 0.3 1.4 2.7 1.5 -1.2 -0.1 0.7 1.6
Arm predicted mass (left) 1.3 6.6 18.8 4.3 -1.9 1.2 1.6 2.5