Best TWAS P=1.41e-16 · Best GWAS P=2.52e-23 conditioned to 0.000193
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | TTK | 0.07 | 0.00 | bslmm | 472 | 0.02 | 3.8e-03 | -2.3 | -5.4 | 6.0e-08 | 0.06 | 0.13 | 0.05 | FALSE |
| 2 | GTEx | Brain Cerebellum | RP11-250B2.5 | 0.43 | 0.11 | lasso | 5 | 0.14 | 4.7e-05 | -5.7 | -7.8 | 4.3e-15 | 0.09 | 0.38 | 0.14 | TRUE |
| 3 | GTEx | Breast Mammary Tissue (Male) | RP11-250B2.5 | 0.12 | 0.09 | lasso | 4 | 0.08 | 7.5e-03 | 4.7 | 5.8 | 5.3e-09 | -0.38 | 0.06 | 0.23 | FALSE |
| 4 | GTEx | Breast Mammary Tissue (Male) | RP11-250B2.6 | 0.12 | 0.00 | enet | 10 | 0.00 | 3.9e-01 | 7.7 | 5.8 | 5.8e-09 | -0.37 | 0.06 | 0.07 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | RP11-250B2.6 | 0.21 | 0.03 | enet | 37 | 0.13 | 4.7e-05 | 2.9 | -8.3 | 1.4e-16 | 0.30 | 0.11 | 0.28 | TRUE |
| 6 | GTEx | Cells Transformed fibroblasts | BCKDHB | 0.16 | 0.02 | enet | 42 | 0.04 | 3.7e-04 | 3.4 | 6.1 | 8.1e-10 | 0.04 | 0.68 | 0.02 | FALSE |
| 7 | GTEx | Colon Transverse | RP11-250B2.3 | 0.17 | 0.12 | enet | 15 | 0.08 | 1.1e-04 | 2.7 | 6.0 | 2.0e-09 | -0.18 | 0.40 | 0.15 | FALSE |
| 8 | GTEx | Heart Atrial Appendage | RP11-250B2.6 | 0.20 | 0.00 | enet | 17 | 0.03 | 2.6e-02 | -3.5 | -6.4 | 1.6e-10 | 0.32 | 0.10 | 0.06 | FALSE |
| 9 | GTEx | Nerve Tibial | RP11-250B2.3 | 0.16 | 0.05 | enet | 9 | 0.05 | 3.5e-04 | 7.0 | 5.2 | 1.7e-07 | -0.22 | 0.51 | 0.02 | FALSE |
| 10 | GTEx | Testis | ELOVL4 | 0.31 | 0.19 | lasso | 7 | 0.18 | 1.9e-08 | -6.3 | -6.3 | 3.3e-10 | 0.09 | 0.96 | 0.01 | TRUE |
| 11 | GTEx | Testis | RP11-250B2.5 | 0.13 | 0.17 | lasso | 3 | 0.14 | 7.0e-07 | -5.8 | -5.3 | 1.4e-07 | -0.25 | 0.81 | 0.02 | FALSE |
| 12 | GTEx | Thyroid | BCKDHB | 0.17 | 0.06 | lasso | 8 | 0.10 | 3.4e-08 | 3.4 | 5.6 | 2.5e-08 | 0.17 | 1.00 | 0.00 | FALSE |
| 13 | GTEx | Thyroid | RP11-250B2.3 | 0.12 | 0.00 | enet | 25 | 0.01 | 2.5e-02 | 7.0 | 7.0 | 2.5e-12 | -0.36 | 0.13 | 0.52 | TRUE |
| 14 | METSIM | Adipose | RP11-250B2.5 | 0.03 | 0.03 | lasso | 4 | 0.01 | 3.5e-03 | 7.1 | 7.1 | 1.5e-12 | -0.30 | 0.34 | 0.10 | TRUE |
| 15 | ROSMAP | Brain Pre-frontal Cortex | RP11-250B2.5 | 0.09 | 0.06 | lasso | 7 | 0.08 | 4.6e-11 | 5.1 | 6.4 | 1.3e-10 | -0.34 | 1.00 | 0.00 | FALSE |
| 16 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | BCKDHB | 0.19 | 0.02 | blup | 137 | 0.06 | 2.6e-03 | 2.9 | 5.7 | 1.1e-08 | -0.05 | 0.03 | 0.05 | FALSE |