Best TWAS P=2.77e-118 · Best GWAS P=4.84e-92 conditioned to 0.000419
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CENPW | 0.04 | 0.06 | lasso | 10 | 0.06 | 2.4e-07 | -5.8 | 5.2 | 2.3e-07 | 0.03 | 1.00 | 0.00 | FALSE |
| 2 | GTEx | Breast Mammary Tissue (Female) | HINT3 | 0.39 | -0.01 | enet | 16 | 0.08 | 2.2e-03 | -4.9 | -6.7 | 2.0e-11 | -0.06 | 0.13 | 0.08 | TRUE |
| 3 | GTEx | Skin Sun Exposed Lower leg | HINT3 | 0.08 | 0.01 | lasso | 4 | 0.03 | 2.0e-03 | -5.2 | -5.8 | 5.1e-09 | -0.04 | 0.25 | 0.03 | FALSE |
| 4 | YFS | Blood | RNF146 | 0.01 | 0.00 | bslmm | 323 | 0.00 | 4.8e-02 | -2.4 | -6.5 | 9.9e-11 | -0.13 | 0.05 | 0.02 | FALSE |
| 5 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RSPO3 | 0.02 | 0.02 | blup | 60 | 0.02 | 2.8e-04 | 19.9 | 23.1 | 2.8e-118 | 0.67 | 0.28 | 0.15 | TRUE |
| 6 | The Cancer Genome Atlas | Breast Invasive Carcinoma | TRMT11 | 0.03 | 0.03 | lasso | 1 | 0.03 | 3.3e-07 | -5.2 | 5.2 | 2.0e-07 | 0.06 | 0.44 | 0.55 | FALSE |
| 7 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CENPW | 0.04 | 0.05 | lasso | 5 | 0.05 | 2.6e-06 | -6.3 | 5.1 | 3.0e-07 | 0.04 | 0.82 | 0.16 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CENPW | 0.04 | 0.06 | blup | 35 | 0.05 | 9.2e-07 | -6.3 | 5.6 | 2.6e-08 | 0.05 | 0.81 | 0.19 | TRUE |
| 9 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | RSPO3 | 0.02 | 0.03 | blup | 60 | 0.02 | 1.3e-03 | 17.7 | 21.6 | 1.4e-103 | 0.62 | 0.36 | 0.19 | FALSE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | RSPO3 | 0.06 | 0.02 | blup | 60 | 0.04 | 9.3e-05 | 17.7 | 12.9 | 8.5e-38 | 0.16 | 0.30 | 0.02 | TRUE |
| 11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | TRMT11 | 0.03 | 0.00 | blup | 33 | 0.01 | 1.3e-02 | -5.4 | 5.9 | 4.6e-09 | 0.09 | 0.04 | 0.64 | FALSE |