Best TWAS P=7.89e-10 · Best GWAS P=7.95e-10 conditioned to 0.0218
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Brain Cerebellum | TNFRSF14 | 0.17 | 0.07 | enet | 6 | 0.10 | 7.6e-04 | -5.7 | -5.8 | 6.3e-09 | 0.91 | 0.01 | 0.95 | FALSE |
2 | GTEx | Brain Cerebellum | RP3-395M20.8 | 0.19 | 0.05 | enet | 8 | 0.06 | 5.9e-03 | -4.0 | -5.6 | 2.0e-08 | 0.83 | 0.02 | 0.90 | FALSE |
3 | GTEx | Esophagus Muscularis | RP3-395M20.12 | 0.08 | 0.06 | enet | 6 | 0.06 | 2.3e-04 | -5.7 | 6.1 | 1.1e-09 | -0.85 | 0.01 | 0.98 | FALSE |
4 | GTEx | Pancreas | TNFRSF14 | 0.13 | 0.04 | enet | 8 | 0.04 | 1.0e-02 | -5.7 | -5.7 | 1.5e-08 | 0.89 | 0.02 | 0.96 | FALSE |
5 | GTEx | Spleen | RP3-395M20.9 | 0.42 | 0.14 | lasso | 3 | 0.15 | 1.1e-04 | 5.0 | 5.2 | 1.8e-07 | -0.66 | 0.05 | 0.67 | FALSE |
6 | GTEx | Uterus | RP3-395M20.9 | 0.25 | 0.08 | lasso | 3 | 0.07 | 1.3e-02 | -4.7 | -5.2 | 1.6e-07 | 0.63 | 0.04 | 0.54 | FALSE |
7 | GTEx | Whole Blood | FAM213B | 0.06 | 0.00 | lasso | 3 | 0.00 | 6.5e-01 | 4.9 | 5.7 | 1.3e-08 | -0.80 | 0.02 | 0.81 | FALSE |
8 | ROSMAP | Brain Pre-frontal Cortex | RP3-395M20.9 | 0.06 | 0.01 | blup | 367 | 0.04 | 5.7e-06 | -4.4 | -6.2 | 7.9e-10 | 0.75 | 0.08 | 0.91 | TRUE |
9 | The Cancer Genome Atlas | Breast Invasive Carcinoma | LOC115110 | 0.01 | 0.01 | enet | 14 | 0.01 | 5.2e-04 | -5.8 | 5.5 | 3.1e-08 | -0.71 | 0.01 | 0.95 | FALSE |
10 | The Cancer Genome Atlas | Breast Invasive Carcinoma | MMEL1 | 0.02 | 0.02 | blup | 38 | 0.03 | 3.3e-06 | -4.3 | 5.5 | 4.7e-08 | -0.86 | 0.13 | 0.86 | FALSE |
11 | The Cancer Genome Atlas | Lung Adenocarcinoma | MMEL1 | 0.05 | 0.03 | blup | 39 | 0.05 | 1.6e-06 | -6.1 | 5.5 | 3.5e-08 | -0.85 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Prostate Adenocarcinoma | LOC115110 | 0.03 | 0.00 | blup | 50 | 0.01 | 1.7e-02 | -6.1 | 5.7 | 9.4e-09 | -0.86 | 0.01 | 0.63 | FALSE |
13 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MMEL1 | 0.10 | 0.12 | enet | 22 | 0.15 | 8.5e-16 | -4.5 | 5.6 | 2.1e-08 | -0.83 | 0.19 | 0.81 | FALSE |