Best TWAS P=1.05e-08 · Best GWAS P=2.03e-07 conditioned to 0.208
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | TMBIM1 | 0.12 | 0.08 | lasso | 5 | 0.10 | 2.9e-08 | 5.2 | -5.1 | 3.0e-07 | -0.94 | 0.02 | 0.98 | FALSE |
2 | GTEx | Adipose Visceral Omentum | RP11-378A13.1 | 0.30 | 0.28 | enet | 30 | 0.32 | 2.9e-17 | 4.5 | -5.1 | 3.0e-07 | -0.90 | 0.07 | 0.93 | FALSE |
3 | GTEx | Artery Aorta | TMBIM1 | 0.17 | 0.20 | enet | 29 | 0.19 | 1.2e-10 | 5.0 | -5.1 | 2.7e-07 | -0.93 | 0.05 | 0.95 | FALSE |
4 | GTEx | Breast Mammary Tissue (Female) | ARPC2 | 0.12 | -0.01 | lasso | 5 | -0.01 | 7.1e-01 | 5.1 | -5.2 | 1.7e-07 | -0.87 | 0.06 | 0.37 | FALSE |
5 | GTEx | Breast Mammary Tissue (Female) | RP11-378A13.1 | 0.30 | 0.11 | lasso | 10 | 0.22 | 3.0e-07 | 5.2 | -5.2 | 2.3e-07 | -0.98 | 0.03 | 0.97 | FALSE |
6 | GTEx | Cells EBV-transformed lymphocytes | TMBIM1 | 0.35 | 0.24 | lasso | 10 | 0.24 | 2.3e-08 | 5.1 | -5.3 | 1.1e-07 | -0.98 | 0.02 | 0.98 | FALSE |
7 | GTEx | Cells EBV-transformed lymphocytes | RP11-378A13.1 | 0.18 | 0.14 | lasso | 6 | 0.13 | 4.6e-05 | 5.1 | -5.1 | 2.8e-07 | -0.97 | 0.03 | 0.93 | FALSE |
8 | GTEx | Cells Transformed fibroblasts | TMBIM1 | 0.15 | 0.25 | lasso | 3 | 0.27 | 2.2e-20 | 5.0 | -5.2 | 1.7e-07 | -0.97 | 0.03 | 0.97 | FALSE |
9 | GTEx | Testis | RP11-378A13.1 | 0.37 | 0.18 | enet | 22 | 0.22 | 2.7e-10 | 5.1 | -5.2 | 1.9e-07 | -0.96 | 0.02 | 0.98 | FALSE |
10 | GTEx | Thyroid | ARPC2 | 0.10 | 0.03 | enet | 8 | 0.04 | 3.0e-04 | 5.0 | -5.4 | 6.4e-08 | -0.87 | 0.03 | 0.95 | FALSE |
11 | METSIM | Adipose | AAMP | 0.03 | 0.00 | bslmm | 433 | 0.01 | 7.1e-03 | 5.1 | -5.7 | 1.0e-08 | -0.77 | 0.05 | 0.87 | TRUE |
12 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | TMBIM1 | 0.10 | 0.04 | blup | 49 | 0.06 | 3.0e-03 | 5.0 | -5.2 | 1.5e-07 | -0.97 | 0.02 | 0.81 | FALSE |
13 | The Cancer Genome Atlas | Soft Tissue Sarcoma | TMBIM1 | 0.07 | 0.04 | blup | 49 | 0.03 | 4.8e-03 | 4.1 | -5.1 | 3.0e-07 | -0.93 | 0.03 | 0.63 | FALSE |
14 | The Cancer Genome Atlas | Thyroid Carcinoma | TMBIM1 | 0.02 | 0.02 | blup | 49 | 0.02 | 9.3e-03 | 5.0 | -5.1 | 2.9e-07 | -0.98 | 0.01 | 0.78 | FALSE |