TWAS hub - AAMP

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0301	0.0151	0.00340	0.005	0.010	0.000	0.011	0.004	6.0e-02	0.00990	0.27000	0.00710	6.8e-02
2	YFS	Blood	0.0206	0.0084	0.00015	0.015	0.011	0.008	0.010	0.012	5.9e-06	0.00011	0.00068	0.00018	4.1e-05

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Ulcerative Colitis	17.0	24.7	32.8	-5.7	-4.1
Irritable Bowel Disease (IBD)	11.1	26.5	30.7	-5.5	-4.7
Ulcerative Colitis (UC)	9.3	17.5	22.7	-4.8	-3.5
Forced vital capacity (FVC)	9.3	36.0	38.3	6.2	5.8
Comparative height size at age 10	8.2	44.9	53.9	6.0	7.3
Forced expiratory volume in 1-second (FEV1)	7.8	26.4	31.5	5.6	4.6
Forced vital capacity (FVC), Best measure	7.0	25.6	30.6	5.5	4.5
Height	6.8	131.0	153.8	10.4	12.4
Trunk fat-free mass	6.8	38.8	42.9	6.5	5.9
Trunk predicted mass	6.8	38.9	42.9	6.5	5.9
Blood Platelet Count	6.7	78.0	86.9	-8.3	-9.3
Standing height	5.4	53.6	57.3	7.1	7.6
Pulse wave reflection index	5.4	6.6	7.3	2.5	2.7
Hayfever/allergic rhinitis (self-reported)	5.3	7.0	7.4	-2.6	-2.7
Forced expiratory volume in 1-second (FEV1), Best measure	5.3	16.8	24.0	4.9	3.1
Ever highly irritable/argumentative for 2 days	5.3	6.4	7.6	-2.3	-2.8
Hearing aid user	5.3	6.0	6.5	2.3	2.5
Heart disease (mother)	5.1	6.3	11.1	3.3	1.2
High cholesterol (Self-reported)	5.1	9.0	9.9	-3.1	-2.9
Crohns Disease (2017)	5.0	11.0	11.2	-3.3	-3.4
Eye problems/disorders: Diabetes related eye disease	5.0	5.5	6.9	-2.6	-2.0
Medication: Cholesterol lowering	5.0	7.7	8.2	-2.7	-2.9
Hand grip strength (left)	4.9	12.8	12.9	3.6	3.6
Relative age voice broke	4.8	7.4	11.0	-1.9	-3.3
Wheeze or whistling in the chest in last year	4.8	8.6	9.2	-2.8	-3.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.8	5.7	6.2	-2.3	-2.5
Chronic bronchitis/emphysema (mother)	4.7	5.4	7.2	-1.9	-2.7
Whole body fat-free mass	4.7	26.9	30.0	5.5	4.9
Whole body water mass	4.7	26.8	30.1	5.5	4.8
Systolic blood pressure, automated reading	4.6	13.4	16.4	-3.2	-4.0
Stomach or abdominal pain in last month	4.5	5.6	6.8	-2.1	-2.6
Sitting height	4.5	31.9	34.8	5.4	5.9
Arm predicted mass (left)	4.5	22.6	25.8	5.1	4.4
Arm predicted mass (right)	4.4	22.6	24.6	5.0	4.5
Blood White Count	4.3	32.0	33.1	5.6	5.8
Arm fat-free mass (right)	4.3	22.0	23.0	4.8	4.6
Average weekly red wine intake	4.3	6.4	6.7	2.6	2.5
Allergy	4.2	9.7	10.4	3.2	3.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	4.2	4.9	6.8	2.6	1.7
Arm fat-free mass (left)	4.2	21.4	23.4	4.8	4.4
Waist Hip Ratio (WHR)	4.1	18.6	20.4	-4.5	-4.1
Allergy or Eczema	4.0	10.6	13.0	-2.9	-3.6
Systolic Blood Pressure	3.9	19.7	24.0	-3.9	-4.9
Medication: Simvastatin	3.9	5.8	6.4	-2.5	-2.3
Peak expiratory flow (PEF)	3.8	8.8	10.9	3.3	2.6
Basal metabolic rate	3.7	20.6	23.4	4.8	4.2
Lung FVC	3.6	18.2	21.4	4.6	3.9
Hayfever, allergic rhinitis or eczema	3.3	7.2	8.9	-2.3	-3.0
Pain experienced in last month	3.3	5.6	7.9	1.8	2.8
Heel T-Score	3.1	24.4	27.5	-4.6	-5.2
Overall health rating	3.1	6.7	8.2	-2.3	-2.9
Medication: Ramipril	3.0	3.9	6.5	-1.1	-2.5
Eye problems/disorders: None of the above	3.0	3.5	5.7	1.1	2.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	3.0	3.5	4.2	-1.7	-2.1
Back pain experienced in last month	3.0	4.3	5.6	-1.8	-2.4
Leg predicted mass (right)	3.0	15.8	17.2	4.2	3.8
LDL Cholesterol	2.9	4.6	5.0	-2.2	-2.1
Alcohol usually taken with meals	2.9	4.8	6.1	1.8	2.5
Medication: Paracetamol	2.9	4.9	7.5	2.7	1.5
Leg fat-free mass (right)	2.9	15.6	16.9	4.1	3.8
Primary Biliary Cirrhosis	2.8	4.0	6.9	-1.1	-2.6
Rheumatoid Arthritis	2.8	3.8	6.2	1.2	2.5
Respiratory disease	2.8	6.2	7.1	-2.7	-2.3
Happiness	2.7	3.3	3.8	1.9	1.6
Crohns Disease (2012)	2.6	4.1	4.4	-2.1	-2.0
Hearing difficulty/problems: Yes	2.5	3.8	4.6	2.1	1.8
Asthma	2.5	4.9	7.5	-2.7	-1.6
Diabetes (father)	2.4	3.0	3.0	-1.7	-1.7
Birth weight	2.4	5.3	5.4	2.3	2.3
Ever taken oral contraceptive pill	2.4	2.7	4.1	2.0	1.1
Number of operations (self-reported)	2.4	3.6	4.4	2.1	1.7
Leg fat-free mass (left)	2.3	12.1	14.3	3.8	3.1
Hand grip strength (right)	2.3	6.2	7.8	2.1	2.8
Hair/balding pattern: Pattern 3	2.3	3.5	4.2	1.6	2.1
Age when periods started (menarche)	2.2	5.4	8.3	-1.6	-2.9
Leg predicted mass (left)	2.2	11.8	14.0	3.7	3.1
Medication for cholesterol, blood pressure or diabetes	2.2	3.7	4.3	1.8	2.1
Cholesterol lowering medication	2.2	3.2	4.0	-2.0	-1.6
Diabetes diagnosed by doctor	2.1	3.4	4.7	-2.2	-1.5
Ever had stillbirth, spontaneous miscarriage or termination	2.1	2.3	2.4	-1.5	-1.6
Commuting to job workplace: Walk	2.1	2.3	4.3	-2.1	-0.5
Asthma (self-reported)	2.1	4.2	6.5	-2.5	-1.4
Medication: Paracetamol	2.1	3.2	5.2	2.3	1.1
Triglycerides	2.0	3.4	4.1	-1.6	-2.0
Maternal smoking around birth	2.0	3.0	4.2	2.1	1.3
Heel bone mineral density (BMD) T-score, automated (left)	2.0	4.5	5.5	-2.3	-1.9
Hair/balding pattern: Pattern 2	2.0	2.6	3.9	-2.0	-1.1
Illnesses of siblings: Diabetes	2.0	2.4	3.2	-1.3	-1.8
Ever had bowel cancer screening	2.0	2.3	4.1	-0.8	-2.0
Eye problems/disorders: Glaucoma	2.0	2.3	3.8	-0.9	-1.9
Time employed in main current job	1.9	2.2	3.5	1.9	1.0
Osteoporosis (self-reported)	1.9	2.4	4.7	2.2	0.3
Ever depressed for a whole week	1.9	2.4	3.1	1.8	1.3
Major Depression (MDD)	1.8	2.2	4.4	2.1	0.3
Bipolar Disorder (2011)	1.8	1.8	3.0	-0.7	-1.7
Fasting Glucose	1.8	2.2	3.8	-1.9	-0.7
Friendships satisfaction	1.8	2.2	2.4	1.6	1.4
Illnesses of father: None of the above (group 1)	1.8	2.2	2.7	1.6	1.3
Prostate Cancer	1.7	2.3	3.7	1.9	1.0
Mouth/teeth dental problems	1.7	2.6	4.8	0.6	2.2
Diabetes (self-reported)	1.7	2.6	4.5	-2.1	-0.8
Medication: Metformin	1.6	2.3	3.2	-1.8	-1.2
Hearing difficulty/problems with background noise	1.6	2.5	3.0	1.7	1.4
Had other major operations	1.6	2.0	3.0	1.7	1.0
Heart attack	1.6	2.0	2.6	-1.2	-1.6
Noisy workplace	1.6	2.0	3.3	-0.9	-1.8
Impedance of arm (left)	1.6	7.2	10.1	-3.2	-2.1
Cardiovascular Disease	1.5	5.0	6.0	-2.0	-2.4
Medication: Atenolol	1.5	1.9	2.0	1.4	1.3
Comparative body size at age 10	1.5	4.1	6.3	2.5	1.4
Medication: Lisinopril	1.5	1.9	3.6	-1.9	-0.5
Supplements: Zinc	1.4	1.5	1.7	-1.3	-1.2
Townsend deprivation index at recruitment	1.4	2.0	2.7	-1.6	-1.1
Mouth/teeth dental problems: Dentures	1.4	2.4	4.5	-0.6	-2.1
Medication: Lansoprazole	1.4	1.6	3.0	-0.5	-1.7
Leg fat percentage (right)	1.4	5.1	6.8	-1.8	-2.6
Qualifications: nursing, teaching	1.4	2.1	3.4	0.9	1.8
Ever had prostate specific antigen (PSA) test	1.4	1.6	1.6	1.2	1.3
Unable to work because of sickness or disability	1.4	1.8	2.5	1.0	1.6
Heart attack/myocardial infarction (self-reported)	1.4	1.8	2.2	-1.2	-1.5
Deep venous thrombosis (DVT) (self-reported)	1.4	1.8	3.1	-0.7	-1.8
Alcohol drinker status: Previous	1.4	1.6	2.5	1.6	0.8
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.7	3.0	0.6	1.7
Blood clot in the leg (DVT)	1.3	1.7	3.2	-0.6	-1.8
Breast cancer (self-reported)	1.3	1.6	2.5	0.8	1.6
Number of self-reported non-cancer illnesses	1.3	2.3	2.3	-1.5	-1.5
Weight	1.2	5.9	7.2	2.7	2.1
Impedance of arm (right)	1.2	5.6	8.5	-2.9	-1.7
Medication: Aspirin	1.2	1.6	2.1	-1.0	-1.4
Arm fat percentage (left)	1.2	4.8	5.1	-2.1	-2.2
Smoking status: Current	1.2	2.0	2.2	-1.5	-1.3
Diastolic blood pressure, automated reading	1.2	3.8	7.1	-0.8	-2.7
Basal cell carcinoma (self-reported)	1.2	1.4	2.4	0.6	1.6
Breast Cancer	1.1	2.6	3.0	-1.7	-1.5
Heel bone mineral density (BMD) T-score, automated (right)	1.1	2.5	3.5	-1.3	-1.9
Arm fat percentage (right)	1.1	4.5	4.8	-2.1	-2.2
Gout (self-reported)	1.1	1.5	1.9	-1.1	-1.4
Body fat percentage	1.1	4.5	4.9	-2.0	-2.2
Commuting to job workplace: Car/motor vehicle	1.1	1.2	1.7	1.3	0.9
Wears glasses or contact lenses	1.1	1.2	1.9	-1.4	-0.8
Impedance of whole body	1.1	5.8	8.6	-2.9	-1.7
Neuroticism	1.0	2.4	3.4	1.8	1.2
Taking other prescription medications	1.0	1.5	1.6	-1.2	-1.3
Birth weight of first child	1.0	1.8	2.2	1.5	1.1
Age at last live birth	1.0	1.4	2.7	-1.6	-0.2
Qualifications: NVQ or HND or HNC or equivalent	1.0	1.2	1.6	-0.9	-1.3
Worry (Nagel 2018)	0.9	1.9	3.4	1.8	0.6
Reaction Time	0.9	1.6	2.4	0.9	1.5
HbA1C	0.9	1.0	1.7	0.5	1.3
Chronotype (morning person)	0.9	2.1	2.8	-1.2	-1.7
Number of treatments/medications taken	0.9	1.6	2.1	-1.0	-1.4
Relative age of first facial hair	0.9	1.9	3.7	-0.4	-1.9
Trunk fat percentage	0.9	3.7	4.0	-1.9	-2.0
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	1.9	1.4	0.6
Alcohol intake versus 10 years previously	0.9	1.3	1.5	-1.0	-1.2
Depression (self-reported)	0.9	1.0	1.3	-1.1	-0.9
Commuting to job workplace: Public transport	0.9	1.1	1.1	-1.0	-1.0
Verbal and Numeric Reasoning (VNR)	0.8	2.0	2.2	1.5	1.3
Medication: Co-codamol	0.8	1.0	1.4	-1.2	-0.7
Medication: Levothyroxine sodium	0.8	1.4	2.5	1.6	0.5
Qualifications: A levels/AS levels or equivalent	0.8	1.8	3.1	0.7	1.8
Length of working week for main job	0.8	0.9	0.9	0.9	0.9
Emphysema/chronic bronchitis	0.8	0.9	1.4	-1.2	-0.7
Knee pain experienced in last month	0.8	1.2	2.0	-0.7	-1.4
Handedness (chirality/laterality): Left-handed	0.8	0.9	1.0	-0.9	-1.0
Miserableness	0.8	1.4	2.3	0.8	1.5
HDL Cholesterol	0.7	1.1	1.9	0.6	1.4
Type 2 Diabetes (T2D) (2018)	0.7	1.4	2.2	-1.5	-0.7
Current tobacco smoking	0.7	1.1	1.1	-1.0	-1.1
Pain all over the body in last month	0.7	0.7	1.4	-0.3	-1.2
Illnesses of mother	0.7	0.8	1.6	-1.3	0.1
Qualifications: College or University degree	0.7	2.1	3.9	0.5	2.0
Medication: Seretide 50 evohaler	0.7	0.8	0.9	-0.9	-0.8
Long-standing illness, disability or infirmity	0.7	1.1	1.5	-0.9	-1.2
Eye problems/disorders: Cataract	0.7	0.8	1.4	-0.3	-1.2
Medication: Aspirin	0.7	0.9	1.2	-0.8	-1.1
Leg fat percentage (left)	0.7	2.7	3.3	-1.4	-1.8
Supplements: Calcium	0.7	0.7	1.5	-0.0	-1.2
Bipolar Disorder (2018)	0.6	1.0	1.9	0.3	-1.4
Bipolar Disorder or Schizophrenia	0.6	1.4	2.9	0.2	-1.7
Body Mass Index (BMI) (2010)	0.6	0.8	1.7	-0.1	-1.3
Sensitivity / hurt feelings	0.6	1.1	1.2	1.0	1.1
Diabetes (mother)	0.6	0.8	0.9	0.9	0.8
Impedance of leg (right)	0.6	3.1	4.4	-2.1	-1.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	1.1	1.0	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.6	1.0	1.4	-1.2	-0.8
Qualifications: None of the above	0.6	1.2	2.2	-0.4	-1.5
Hip circumference	0.6	2.8	4.3	2.1	1.1
Breastfed as a baby	0.6	0.8	1.2	1.1	0.6
Number of full brothers	0.6	0.7	1.3	-0.4	-1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	1.1	-0.5	1.0
Health satisfaction	0.6	0.7	0.9	-0.8	-0.9
Medication for pain relief, constipation, heartburn	0.6	1.0	1.4	-1.2	-0.8
Number of full sisters	0.6	0.7	1.2	-0.3	-1.1
Chest pain or discomfort	0.6	0.8	1.6	-0.2	-1.3
Loneliness, isolation	0.6	0.9	1.6	1.3	0.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.3	2.6	1.6	0.1
Pack years of smoking	0.6	0.9	0.9	0.9	1.0
Neuroticism (Nagel 2018)	0.5	1.1	2.0	1.4	0.4
Blood Eosinophil Count	0.5	4.2	7.0	1.2	2.6
Smoking Status	0.5	1.2	1.8	-0.8	-1.3
Lung FEV1/FVC ratio	0.5	2.4	4.0	0.9	-2.0
Average weekly spirits intake	0.5	0.7	0.9	0.9	0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.1	-0.1	-1.1
Qualifications: CSEs or equivalent	0.5	0.7	1.3	-0.3	-1.1
Falls in the last year	0.5	0.6	0.8	-0.7	-0.9
Tense / ‘highly strung’	0.5	0.8	1.1	1.1	0.7
Medication: Ventolin 100micrograms inhaler	0.5	0.7	1.2	-1.1	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	1.0	1.0	0.6
Medication: Ibuprofen	0.5	0.6	1.1	-0.0	1.1
Illnesses of father: Heart disease	0.5	0.7	1.2	-1.1	0.5
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.1	1.4	0.8	1.2
Osteoarthritis (self-reported)	0.5	0.6	1.0	0.4	1.0
Medication: Bendroflumethiazide	0.5	0.7	1.0	0.6	1.0
Ovarian Cancer	0.4	0.6	0.7	-0.8	-0.6
Neuroticism (2016)	0.4	0.6	0.9	0.5	-0.9
Fed-up feelings	0.4	0.7	1.2	-0.5	-1.1
Supplements: Glucosamine	0.4	0.5	1.1	-0.0	-1.0
Impedance of leg (left)	0.4	1.9	3.6	-1.9	-0.5
Nervous feelings	0.4	0.7	0.8	0.8	0.9
Fluid intelligence score	0.4	0.8	1.4	1.2	0.5
Lung cancer (father)	0.4	0.4	0.6	0.8	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	1.6	1.3	0.2
Exposure to tobacco smoke outside home	0.4	0.5	0.5	0.7	0.7
Worry too long after embarrassment	0.4	0.7	1.4	-0.3	1.2
Age at first live birth	0.4	0.7	1.0	-1.0	-0.7
Medication: Allopurinol	0.4	0.5	0.6	-0.8	-0.6
Mood swings	0.4	0.7	1.3	-0.3	-1.1
Average weekly champagne plus white wine intake	0.4	0.5	0.5	0.7	0.7
Financial situation satisfaction	0.4	0.6	0.7	0.6	0.8
Illnesses of father: High blood pressure	0.4	0.5	1.0	-1.0	0.0
Risk taking	0.4	0.7	1.3	-0.2	-1.1
Fractured/broken bones in last 5 years	0.4	0.5	1.0	-1.0	-0.1
Depression (Nagel 2018)	0.3	0.4	0.8	0.9	0.2
Schizophrenia (2018)	0.3	0.6	1.2	-0.0	-1.1
Alzheimer’s Disease (in mother)	0.3	0.4	0.5	-0.4	0.7
Lupus	0.3	0.4	0.5	0.7	0.6
BMI	0.3	1.5	2.9	0.1	-1.7
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.4	0.9
Average weekly fortified wine intake	0.3	0.3	0.5	-0.4	0.7
Illnesses of siblings	0.3	0.4	0.8	0.1	0.9
Neuroticism score	0.3	0.6	0.8	0.9	0.6
Father’s age at death	0.3	0.4	0.7	-0.8	-0.3
Medication: Amlodipine	0.3	0.4	0.7	0.4	-0.8
Number of children fathered	0.3	0.3	0.6	0.8	-0.1
Migraine (self-reported)	0.3	0.4	0.6	0.8	-0.3
Medication: Omeprazole	0.3	0.4	0.6	-0.5	-0.8
Had major operations	0.3	0.3	0.7	0.8	-0.1
Supplements: Vitamin C	0.3	0.3	0.6	0.8	-0.0
Mother’s age at death	0.3	0.4	0.6	0.8	0.6
Pain type(s) experienced in last month: Hip pain	0.3	0.3	0.6	0.2	-0.8
Depressed Affect (Nagel 2018)	0.2	0.4	0.7	0.9	-0.1
Schizophrenia vs Biploar Disorder	0.2	0.2	0.2	-0.4	-0.5
Age at First Birth	0.2	0.3	0.5	0.7	0.4
Schizophrenia (2014)	0.2	0.5	0.9	0.3	-1.0
Blood Red Count	0.2	1.9	3.6	0.5	1.9
Hypothyroidism (self reported)	0.2	0.4	0.6	0.8	-0.5
Tanning	0.2	2.2	3.6	1.9	0.9
Ever had hysterectomy (womb removed)	0.2	0.2	0.4	-0.6	-0.3
Angina	0.2	0.3	0.3	-0.6	-0.5
Pack years adult smoking proportion	0.2	0.4	0.5	0.5	0.7
Body mass index (BMI)	0.2	0.9	1.6	-0.4	-1.3
Waist circumference	0.2	0.8	1.2	-0.6	-1.1
Pulse rate	0.2	0.3	0.3	-0.5	0.5
Prospective memory result	0.2	0.2	0.4	-0.6	-0.2
Qualifications: O levels/GCSEs or equivalent	0.2	0.2	0.4	0.2	0.7
Glaucoma (self-reported)	0.2	0.2	0.4	0.1	-0.6
Shortness of breath walking on level ground	0.2	0.3	0.4	-0.4	-0.6
Angina (self-reported)	0.2	0.3	0.3	-0.6	-0.6
Pulse rate, automated reading	0.2	0.5	0.9	-0.9	0.4
Alcohol intake frequency.	0.2	0.6	0.6	0.8	-0.7
Leg pain on walking	0.2	0.2	0.3	0.3	-0.6
Guilty feelings	0.2	0.3	0.5	0.0	-0.7
Myopia	0.2	0.3	0.3	-0.6	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.3	-0.3	-0.5
Heart disease (siblings)	0.2	0.3	0.6	-0.1	-0.8
Intelligence (Savage-Jansen 2018)	0.1	0.4	0.5	0.5	-0.7
Alzheimer’s Disease (in father)	0.1	0.1	0.1	-0.3	-0.3
Coronary Artery Disease (CAD)	0.1	0.1	0.2	0.1	0.4
Mean Putamen Volume	0.1	0.1	0.2	-0.4	0.1
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.2	-0.2	-0.4
Hair Pigment	0.1	2.8	3.4	1.5	1.8
Ever used hormone-replacement therapy (HRT)	0.1	0.2	0.3	-0.5	-0.3
Vitamin and mineral supplements	0.1	0.2	0.4	-0.0	0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.2	0.5	-0.3
Serious illness, injury or assault to yourself	0.1	0.1	0.1	0.0	-0.4
High blood pressure	0.1	0.2	0.2	0.5	-0.3
Chronic bronchitis/emphysema (father)	0.1	0.2	0.3	0.6	-0.0
Number of incorrect matches in round	0.1	0.1	0.1	-0.3	0.4
Had menopause	0.1	0.1	0.1	0.4	0.1
Financial difficulties in last 2 years	0.1	0.1	0.1	-0.3	0.3
Worrier / anxious feelings	0.1	0.2	0.2	0.4	-0.5
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	-0.1	-0.5
Number of live births	0.1	0.2	0.3	-0.2	-0.5
Pulse wave Arterial Stiffness index	0.1	0.1	0.3	-0.0	0.5
Exposure to tobacco smoke at home	0.1	0.1	0.2	0.2	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.2	0.4	0.4
Hair/balding pattern: Pattern 4	0.1	0.2	0.4	-0.6	-0.1
Loud music exposure frequency	0.1	0.1	0.1	-0.3	0.1
Headache pain in last month	0.1	0.2	0.5	0.7	-0.2
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.1	-0.3	-0.4
Neck or shoulder pain in last month	0.1	0.1	0.1	0.3	0.2
Medication: Blood pressure	0.1	0.2	0.4	0.6	0.1
Mean time to correctly identify matches	0.1	0.1	0.1	0.2	0.4
Whole body fat mass	0.1	0.3	0.5	-0.3	-0.7
Leg fat mass (right)	0.1	0.4	0.8	-0.2	-0.9
Suffer from ‘nerves’	0.1	0.2	0.4	0.7	-0.1
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.2	-0.4	-0.4
Smoking status: Previous	0.1	0.1	0.3	0.0	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.1	0.1	0.2	-0.2	-0.4
Mineral and other dietary supplements	0.1	0.1	0.2	-0.2	0.5
Medication: Gliclazide	0.1	0.1	0.2	-0.2	0.5
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	-0.4	0.3
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.1	-0.3	-0.2
Medication: Atorvastatin	0.1	0.1	0.3	-0.2	-0.5
Average weekly beer plus cider intake	0.1	0.2	0.2	-0.5	-0.3
Age started oral contraceptive pill	0.1	0.1	0.2	0.4	0.1
Commuting to job workplace: Cycle	0.1	0.2	0.4	0.1	0.6
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.2	-0.5	0.5
Alzheimer’s Disease (including proxy)	0.0	0.0	0.0	-0.1	0.0
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.0	-0.3
Medication for hormone replacement therapy	0.0	0.0	0.0	0.1	-0.2
Severe depression (siblings)	0.0	0.0	0.1	0.1	-0.2
Multivitamins +/- minerals	0.0	0.0	0.0	-0.1	0.1
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	-0.0	-0.1
High blood pressure (mother)	0.0	0.0	0.1	0.3	0.0
Trunk fat mass	0.0	0.0	0.0	-0.0	-0.2
Past tobacco smoking	0.0	0.1	0.1	-0.2	0.4
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.1	0.1	-0.2
Arm fat mass (right)	0.0	0.1	0.3	-0.0	-0.5
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	0.2	0.1
High blood pressure (siblings)	0.0	0.0	0.1	0.1	-0.3
Pulse wave peak to peak time	0.0	0.0	0.1	0.3	-0.2
Family relationship satisfaction	0.0	0.0	0.0	0.1	0.0
Hypertension (Self-reported)	0.0	0.0	0.1	0.2	-0.3
Medication for cholesterol	0.0	0.0	0.1	0.2	0.1
Arm fat mass (left)	0.0	0.1	0.1	-0.0	-0.4
Medication: Blood pressure	0.0	0.1	0.2	0.1	0.4
Alcohol drinker status: Never	0.0	0.1	0.1	0.2	0.3
Ever smoked	0.0	0.0	0.1	-0.0	-0.3
Irritability	0.0	0.0	0.1	-0.3	0.1
Leg fat mass (left)	0.0	0.1	0.2	0.1	-0.4

Hub : Genes

AAMP

Models

Trait associations