[Hub]/) : Traits : Ulcerative Colitis :

chr3:47,911,521-50,932,324

Best TWAS P=2.57e-14 · Best GWAS P=2.33e-15 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex MST1 0.16 0.05 blup 314 0.07 4.0e-09 5.5 7.0 2.9e-12 0.71 0.07 0.93 FALSE
2 CommonMind Brain Pre-frontal Cortex RNF123 0.14 0.10 blup 324 0.12 4.7e-14 -4.9 -5.4 6.4e-08 -0.68 0.99 0.01 FALSE
3 GTEx Adipose Subcutaneous NICN1 0.20 0.12 lasso 17 0.13 6.7e-11 -3.4 5.5 3.0e-08 0.64 0.90 0.10 FALSE
4 GTEx Adipose Visceral Omentum PRKAR2A 0.13 0.08 lasso 10 0.05 1.8e-03 -3.3 -5.1 2.6e-07 -0.43 0.18 0.50 FALSE
5 GTEx Artery Aorta SEMA3F 0.12 0.03 enet 20 0.06 3.6e-04 -4.8 -5.3 1.0e-07 -0.53 0.13 0.64 FALSE
6 GTEx Artery Coronary NICN1 0.10 0.01 lasso 13 0.01 1.3e-01 -3.3 5.4 5.5e-08 0.63 0.10 0.33 FALSE
7 GTEx Artery Tibial NICN1 0.20 0.17 enet 27 0.23 3.0e-18 -3.4 6.7 2.4e-11 0.72 0.92 0.08 FALSE
8 GTEx Artery Tibial MST1R 0.06 0.02 lasso 5 0.02 1.5e-02 -4.2 -6.4 1.8e-10 -0.75 0.16 0.21 FALSE
9 GTEx Artery Tibial IP6K1 0.03 0.00 enet 22 0.01 2.5e-02 -5.1 -7.1 1.2e-12 -0.60 0.18 0.32 FALSE
10 GTEx Artery Tibial NICN1-AS1 0.13 0.08 lasso 5 0.12 2.5e-09 -3.4 5.2 1.9e-07 0.62 0.94 0.06 FALSE
11 GTEx Brain Cerebellar Hemisphere RNF123 0.20 0.24 enet 29 0.20 7.7e-06 -5.1 -5.2 2.0e-07 -0.69 0.58 0.15 FALSE
12 GTEx Brain Cerebellum MST1R 0.19 0.24 enet 22 0.20 1.8e-06 3.6 -5.4 5.5e-08 -0.63 0.81 0.16 FALSE
13 GTEx Brain Cerebellum FAM212A 0.27 0.35 lasso 5 0.34 9.7e-11 -5.1 -5.2 2.2e-07 -0.67 0.99 0.00 FALSE
14 GTEx Brain Cerebellum GPX1 0.31 0.09 enet 19 0.23 2.0e-07 7.0 -6.2 5.1e-10 -0.80 0.06 0.93 FALSE
15 GTEx Brain Frontal Cortex BA9 GPX1 0.16 0.06 lasso 6 0.15 7.9e-05 -3.1 -5.3 1.3e-07 -0.65 0.07 0.77 FALSE
16 GTEx Brain Hypothalamus MST1 0.32 0.13 lasso 3 0.12 9.4e-04 7.1 6.5 6.7e-11 0.90 0.03 0.82 FALSE
17 GTEx Breast Mammary Tissue RNF123 0.11 0.07 enet 14 0.02 3.2e-02 -5.1 -5.5 3.1e-08 -0.59 0.48 0.34 FALSE
18 GTEx Cells EBV-transformed lymphocytes USP4 0.08 0.05 lasso 2 0.09 8.7e-04 -3.5 -6.1 9.9e-10 -0.70 0.11 0.61 FALSE
19 GTEx Cells Transformed fibroblasts TCTA 0.07 0.05 enet 14 0.07 9.4e-06 -1.9 5.3 9.8e-08 0.51 0.37 0.08 FALSE
20 GTEx Cells Transformed fibroblasts APEH 0.13 0.12 lasso 15 0.12 1.3e-09 7.4 7.3 3.1e-13 0.98 0.04 0.96 FALSE
21 GTEx Cells Transformed fibroblasts RNF123 0.08 0.09 enet 14 0.06 1.7e-05 -5.1 -5.7 1.2e-08 -0.69 0.81 0.17 FALSE
22 GTEx Esophagus Mucosa RBM6 0.18 0.21 enet 18 0.23 3.0e-15 -4.5 5.2 1.9e-07 0.55 1.00 0.00 FALSE
23 GTEx Esophagus Mucosa APEH 0.16 0.08 lasso 4 0.12 1.2e-08 2.6 5.5 3.2e-08 0.77 0.06 0.94 FALSE
24 GTEx Esophagus Mucosa FAM212A 0.19 0.26 enet 24 0.27 4.4e-18 -5.2 -5.1 3.0e-07 -0.66 1.00 0.00 FALSE
25 GTEx Esophagus Muscularis NICN1 0.11 0.03 enet 22 0.07 2.7e-05 7.4 6.9 4.4e-12 0.85 0.04 0.96 FALSE
26 GTEx Esophagus Muscularis MST1R 0.05 0.00 lasso 5 0.05 3.6e-04 4.2 -5.2 2.1e-07 -0.58 0.22 0.38 FALSE
27 GTEx Esophagus Muscularis GPX1 0.13 0.05 lasso 14 0.06 1.1e-04 7.0 -6.2 4.6e-10 -0.82 0.18 0.80 FALSE
28 GTEx Esophagus Muscularis NICN1-AS1 0.09 0.04 enet 14 0.06 2.3e-04 7.1 6.5 6.3e-11 0.84 0.06 0.89 FALSE
29 GTEx Heart Atrial Appendage RNF123 0.06 0.04 lasso 2 0.02 4.0e-02 -4.9 -6.2 4.7e-10 -0.84 0.16 0.54 FALSE
30 GTEx Heart Atrial Appendage MST1R 0.08 0.00 enet 22 0.03 1.5e-02 -4.0 -5.3 1.4e-07 -0.42 0.27 0.14 FALSE
31 GTEx Lung RNF123 0.13 0.05 enet 18 0.07 5.8e-06 -5.0 -5.4 5.2e-08 -0.77 0.52 0.43 FALSE
32 GTEx Lung GPX1 0.04 0.02 enet 13 0.04 5.7e-04 7.1 -6.3 2.8e-10 -0.85 0.06 0.76 FALSE
33 GTEx Muscle Skeletal FAM212A 0.05 0.08 lasso 3 0.07 4.9e-07 7.8 -7.6 2.6e-14 -0.97 0.02 0.98 TRUE
34 GTEx Muscle Skeletal SLC26A6 0.12 0.11 lasso 6 0.10 2.1e-10 5.8 5.9 4.0e-09 0.42 0.01 0.99 FALSE
35 GTEx Nerve Tibial NICN1 0.13 0.15 enet 21 0.16 1.4e-11 -3.2 5.6 2.2e-08 0.67 0.94 0.06 FALSE
36 GTEx Nerve Tibial MST1 0.27 0.03 lasso 8 0.10 1.9e-07 1.9 5.8 8.6e-09 0.80 0.04 0.96 FALSE
37 GTEx Nerve Tibial NICN1-AS1 0.15 0.11 lasso 5 0.13 1.1e-09 -3.2 5.8 5.7e-09 0.74 0.28 0.71 FALSE
38 GTEx Nerve Tibial RHOA-IT1 0.05 0.02 enet 14 0.03 4.7e-03 7.1 7.5 6.1e-14 0.85 0.13 0.43 FALSE
39 GTEx Skin Not Sun Exposed Suprapubic RBM6 0.16 0.17 enet 24 0.23 1.2e-12 4.2 5.3 1.3e-07 0.49 1.00 0.00 FALSE
40 GTEx Skin Not Sun Exposed Suprapubic MST1 0.12 0.09 enet 34 0.11 1.5e-06 7.8 5.4 7.9e-08 0.73 0.02 0.98 FALSE
41 GTEx Skin Sun Exposed Lower leg MST1 0.07 0.00 enet 10 0.01 4.1e-02 7.1 6.8 1.2e-11 0.85 0.03 0.89 FALSE
42 GTEx Skin Sun Exposed Lower leg FAM212A 0.05 0.07 enet 16 0.06 1.1e-05 -5.2 -5.1 3.0e-07 -0.66 0.96 0.03 FALSE
43 GTEx Spleen UBA7 0.19 0.14 lasso 22 0.11 8.8e-04 -5.1 5.2 1.8e-07 0.66 0.27 0.46 FALSE
44 GTEx Testis MON1A 0.08 0.06 enet 13 0.05 2.4e-03 -4.8 5.2 2.2e-07 0.50 0.41 0.06 FALSE
45 GTEx Testis GPX1 0.08 0.00 lasso 6 0.04 1.0e-02 6.9 -7.5 5.9e-14 -0.78 0.05 0.73 FALSE
46 GTEx Thyroid MST1 0.18 0.01 enet 11 0.05 8.1e-05 2.6 6.1 9.7e-10 0.73 0.02 0.97 FALSE
47 GTEx Vagina RBM6 0.24 0.22 enet 27 0.21 1.5e-05 4.2 5.5 4.7e-08 0.53 0.72 0.14 FALSE
48 METSIM Adipose APEH 0.09 0.06 enet 22 0.07 3.7e-11 5.5 6.3 3.7e-10 0.76 0.09 0.91 FALSE
49 METSIM Adipose MST1R 0.03 0.02 blup 331 0.02 1.7e-03 -4.5 -5.1 2.9e-07 -0.48 0.86 0.01 FALSE
50 METSIM Adipose SLC26A6 0.03 0.03 lasso 10 0.02 1.2e-04 5.9 5.8 5.0e-09 0.42 0.02 0.98 FALSE
51 NTR Blood AMT 0.02 0.01 lasso 13 0.02 5.1e-06 -3.7 6.0 1.9e-09 0.83 0.28 0.72 FALSE
52 NTR Blood QRICH1 0.01 0.00 blup 276 0.01 1.6e-04 4.8 -6.7 1.6e-11 -0.66 0.38 0.47 FALSE
53 ROSMAP Brain Pre-frontal Cortex MST1 0.20 0.07 bslmm 307 0.08 8.8e-11 5.6 6.0 2.5e-09 0.56 0.98 0.01 FALSE
54 ROSMAP Brain Pre-frontal Cortex SLC38A3 0.03 0.03 lasso 5 0.02 6.4e-04 -5.1 5.2 2.4e-07 0.35 0.04 0.96 FALSE
55 ROSMAP Brain Pre-frontal Cortex GPX1 0.23 0.25 lasso 10 0.30 1.5e-39 -3.3 -5.6 2.2e-08 -0.68 1.00 0.00 FALSE
56 YFS Blood APEH 0.11 0.05 enet 46 0.06 1.3e-19 7.8 5.9 2.8e-09 0.78 0.01 0.99 FALSE
57 YFS Blood COL7A1 0.01 0.01 bslmm 247 0.01 8.0e-04 4.8 5.7 1.3e-08 0.51 0.05 0.87 FALSE
58 The Cancer Genome Atlas Bladder Urothelial Carcinoma C3orf62 0.04 0.01 enet 7 0.01 2.0e-02 4.8 -5.4 5.8e-08 -0.58 0.01 0.70 FALSE
59 The Cancer Genome Atlas Breast Invasive Carcinoma AMIGO3 0.01 0.00 enet 13 0.01 5.7e-03 -1.9 -5.2 1.6e-07 -0.78 0.01 0.49 FALSE
60 The Cancer Genome Atlas Glioblastoma Multiforme AMIGO3 0.18 0.02 enet 24 0.07 2.9e-03 -1.9 -6.2 4.8e-10 -0.69 0.02 0.25 FALSE
61 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma APEH 0.02 0.02 blup 49 0.02 2.5e-03 7.6 7.5 5.5e-14 0.95 0.01 0.89 FALSE
62 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma UBA7 0.02 0.02 blup 30 0.02 3.8e-03 -4.9 5.4 6.5e-08 0.68 0.01 0.78 FALSE
63 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma UBA7 0.13 0.16 lasso 6 0.15 1.1e-08 -5.0 5.4 5.9e-08 0.70 0.02 0.98 FALSE
64 The Cancer Genome Atlas Brain Lower Grade Glioma C3orf62 0.02 0.00 blup 31 0.02 6.4e-03 -3.5 -5.9 2.8e-09 -0.68 0.01 0.39 FALSE
65 The Cancer Genome Atlas Brain Lower Grade Glioma TRAIP 0.02 0.01 enet 8 0.01 3.1e-02 -4.8 -5.5 4.0e-08 -0.57 0.02 0.62 FALSE
66 The Cancer Genome Atlas Lung Squamous Cell Carcinoma UBA7 0.02 0.01 blup 30 0.02 5.3e-03 -5.1 5.2 1.6e-07 0.63 0.01 0.86 FALSE
67 The Cancer Genome Atlas Pancreatic Adenocarcinoma UBA7 0.11 0.14 enet 7 0.11 2.7e-05 -5.1 5.2 1.9e-07 0.66 0.02 0.98 FALSE
68 The Cancer Genome Atlas Thyroid Carcinoma APEH 0.04 0.03 lasso 2 0.03 3.9e-04 5.7 6.2 7.4e-10 0.75 0.04 0.77 FALSE