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chr3:47,911,521-50,932,324

Best TWAS P=2.57e-14 · Best GWAS P=2.33e-15 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	MST1	0.16	0.05	blup	314	0.07	4.0e-09	5.5	7.0	2.9e-12	0.71	0.07	0.93	FALSE
2	CommonMind	Brain Pre-frontal Cortex	RNF123	0.14	0.10	blup	324	0.12	4.7e-14	-4.9	-5.4	6.4e-08	-0.68	0.99	0.01	FALSE
3	GTEx	Adipose Subcutaneous	NICN1	0.20	0.12	lasso	17	0.13	6.7e-11	-3.4	5.5	3.0e-08	0.64	0.90	0.10	FALSE
4	GTEx	Adipose Visceral Omentum	PRKAR2A	0.13	0.08	lasso	10	0.05	1.8e-03	-3.3	-5.1	2.6e-07	-0.43	0.18	0.50	FALSE
5	GTEx	Artery Aorta	SEMA3F	0.12	0.03	enet	20	0.06	3.6e-04	-4.8	-5.3	1.0e-07	-0.53	0.13	0.64	FALSE
6	GTEx	Artery Coronary	NICN1	0.10	0.01	lasso	13	0.01	1.3e-01	-3.3	5.4	5.5e-08	0.63	0.10	0.33	FALSE
7	GTEx	Artery Tibial	NICN1	0.20	0.17	enet	27	0.23	3.0e-18	-3.4	6.7	2.4e-11	0.72	0.92	0.08	FALSE
8	GTEx	Artery Tibial	MST1R	0.06	0.02	lasso	5	0.02	1.5e-02	-4.2	-6.4	1.8e-10	-0.75	0.16	0.21	FALSE
9	GTEx	Artery Tibial	IP6K1	0.03	0.00	enet	22	0.01	2.5e-02	-5.1	-7.1	1.2e-12	-0.60	0.18	0.32	FALSE
10	GTEx	Artery Tibial	NICN1-AS1	0.13	0.08	lasso	5	0.12	2.5e-09	-3.4	5.2	1.9e-07	0.62	0.94	0.06	FALSE
11	GTEx	Brain Cerebellar Hemisphere	RNF123	0.20	0.24	enet	29	0.20	7.7e-06	-5.1	-5.2	2.0e-07	-0.69	0.58	0.15	FALSE
12	GTEx	Brain Cerebellum	MST1R	0.19	0.24	enet	22	0.20	1.8e-06	3.6	-5.4	5.5e-08	-0.63	0.81	0.16	FALSE
13	GTEx	Brain Cerebellum	FAM212A	0.27	0.35	lasso	5	0.34	9.7e-11	-5.1	-5.2	2.2e-07	-0.67	0.99	0.00	FALSE
14	GTEx	Brain Cerebellum	GPX1	0.31	0.09	enet	19	0.23	2.0e-07	7.0	-6.2	5.1e-10	-0.80	0.06	0.93	FALSE
15	GTEx	Brain Frontal Cortex BA9	GPX1	0.16	0.06	lasso	6	0.15	7.9e-05	-3.1	-5.3	1.3e-07	-0.65	0.07	0.77	FALSE
16	GTEx	Brain Hypothalamus	MST1	0.32	0.13	lasso	3	0.12	9.4e-04	7.1	6.5	6.7e-11	0.90	0.03	0.82	FALSE
17	GTEx	Breast Mammary Tissue	RNF123	0.11	0.07	enet	14	0.02	3.2e-02	-5.1	-5.5	3.1e-08	-0.59	0.48	0.34	FALSE
18	GTEx	Cells EBV-transformed lymphocytes	USP4	0.08	0.05	lasso	2	0.09	8.7e-04	-3.5	-6.1	9.9e-10	-0.70	0.11	0.61	FALSE
19	GTEx	Cells Transformed fibroblasts	TCTA	0.07	0.05	enet	14	0.07	9.4e-06	-1.9	5.3	9.8e-08	0.51	0.37	0.08	FALSE
20	GTEx	Cells Transformed fibroblasts	APEH	0.13	0.12	lasso	15	0.12	1.3e-09	7.4	7.3	3.1e-13	0.98	0.04	0.96	FALSE
21	GTEx	Cells Transformed fibroblasts	RNF123	0.08	0.09	enet	14	0.06	1.7e-05	-5.1	-5.7	1.2e-08	-0.69	0.81	0.17	FALSE
22	GTEx	Esophagus Mucosa	RBM6	0.18	0.21	enet	18	0.23	3.0e-15	-4.5	5.2	1.9e-07	0.55	1.00	0.00	FALSE
23	GTEx	Esophagus Mucosa	APEH	0.16	0.08	lasso	4	0.12	1.2e-08	2.6	5.5	3.2e-08	0.77	0.06	0.94	FALSE
24	GTEx	Esophagus Mucosa	FAM212A	0.19	0.26	enet	24	0.27	4.4e-18	-5.2	-5.1	3.0e-07	-0.66	1.00	0.00	FALSE
25	GTEx	Esophagus Muscularis	NICN1	0.11	0.03	enet	22	0.07	2.7e-05	7.4	6.9	4.4e-12	0.85	0.04	0.96	FALSE
26	GTEx	Esophagus Muscularis	MST1R	0.05	0.00	lasso	5	0.05	3.6e-04	4.2	-5.2	2.1e-07	-0.58	0.22	0.38	FALSE
27	GTEx	Esophagus Muscularis	GPX1	0.13	0.05	lasso	14	0.06	1.1e-04	7.0	-6.2	4.6e-10	-0.82	0.18	0.80	FALSE
28	GTEx	Esophagus Muscularis	NICN1-AS1	0.09	0.04	enet	14	0.06	2.3e-04	7.1	6.5	6.3e-11	0.84	0.06	0.89	FALSE
29	GTEx	Heart Atrial Appendage	RNF123	0.06	0.04	lasso	2	0.02	4.0e-02	-4.9	-6.2	4.7e-10	-0.84	0.16	0.54	FALSE
30	GTEx	Heart Atrial Appendage	MST1R	0.08	0.00	enet	22	0.03	1.5e-02	-4.0	-5.3	1.4e-07	-0.42	0.27	0.14	FALSE
31	GTEx	Lung	RNF123	0.13	0.05	enet	18	0.07	5.8e-06	-5.0	-5.4	5.2e-08	-0.77	0.52	0.43	FALSE
32	GTEx	Lung	GPX1	0.04	0.02	enet	13	0.04	5.7e-04	7.1	-6.3	2.8e-10	-0.85	0.06	0.76	FALSE
33	GTEx	Muscle Skeletal	FAM212A	0.05	0.08	lasso	3	0.07	4.9e-07	7.8	-7.6	2.6e-14	-0.97	0.02	0.98	TRUE
34	GTEx	Muscle Skeletal	SLC26A6	0.12	0.11	lasso	6	0.10	2.1e-10	5.8	5.9	4.0e-09	0.42	0.01	0.99	FALSE
35	GTEx	Nerve Tibial	NICN1	0.13	0.15	enet	21	0.16	1.4e-11	-3.2	5.6	2.2e-08	0.67	0.94	0.06	FALSE
36	GTEx	Nerve Tibial	MST1	0.27	0.03	lasso	8	0.10	1.9e-07	1.9	5.8	8.6e-09	0.80	0.04	0.96	FALSE
37	GTEx	Nerve Tibial	NICN1-AS1	0.15	0.11	lasso	5	0.13	1.1e-09	-3.2	5.8	5.7e-09	0.74	0.28	0.71	FALSE
38	GTEx	Nerve Tibial	RHOA-IT1	0.05	0.02	enet	14	0.03	4.7e-03	7.1	7.5	6.1e-14	0.85	0.13	0.43	FALSE
39	GTEx	Skin Not Sun Exposed Suprapubic	RBM6	0.16	0.17	enet	24	0.23	1.2e-12	4.2	5.3	1.3e-07	0.49	1.00	0.00	FALSE
40	GTEx	Skin Not Sun Exposed Suprapubic	MST1	0.12	0.09	enet	34	0.11	1.5e-06	7.8	5.4	7.9e-08	0.73	0.02	0.98	FALSE
41	GTEx	Skin Sun Exposed Lower leg	MST1	0.07	0.00	enet	10	0.01	4.1e-02	7.1	6.8	1.2e-11	0.85	0.03	0.89	FALSE
42	GTEx	Skin Sun Exposed Lower leg	FAM212A	0.05	0.07	enet	16	0.06	1.1e-05	-5.2	-5.1	3.0e-07	-0.66	0.96	0.03	FALSE
43	GTEx	Spleen	UBA7	0.19	0.14	lasso	22	0.11	8.8e-04	-5.1	5.2	1.8e-07	0.66	0.27	0.46	FALSE
44	GTEx	Testis	MON1A	0.08	0.06	enet	13	0.05	2.4e-03	-4.8	5.2	2.2e-07	0.50	0.41	0.06	FALSE
45	GTEx	Testis	GPX1	0.08	0.00	lasso	6	0.04	1.0e-02	6.9	-7.5	5.9e-14	-0.78	0.05	0.73	FALSE
46	GTEx	Thyroid	MST1	0.18	0.01	enet	11	0.05	8.1e-05	2.6	6.1	9.7e-10	0.73	0.02	0.97	FALSE
47	GTEx	Vagina	RBM6	0.24	0.22	enet	27	0.21	1.5e-05	4.2	5.5	4.7e-08	0.53	0.72	0.14	FALSE
48	METSIM	Adipose	APEH	0.09	0.06	enet	22	0.07	3.7e-11	5.5	6.3	3.7e-10	0.76	0.09	0.91	FALSE
49	METSIM	Adipose	MST1R	0.03	0.02	blup	331	0.02	1.7e-03	-4.5	-5.1	2.9e-07	-0.48	0.86	0.01	FALSE
50	METSIM	Adipose	SLC26A6	0.03	0.03	lasso	10	0.02	1.2e-04	5.9	5.8	5.0e-09	0.42	0.02	0.98	FALSE
51	NTR	Blood	AMT	0.02	0.01	lasso	13	0.02	5.1e-06	-3.7	6.0	1.9e-09	0.83	0.28	0.72	FALSE
52	NTR	Blood	QRICH1	0.01	0.00	blup	276	0.01	1.6e-04	4.8	-6.7	1.6e-11	-0.66	0.38	0.47	FALSE
53	ROSMAP	Brain Pre-frontal Cortex	MST1	0.20	0.07	bslmm	307	0.08	8.8e-11	5.6	6.0	2.5e-09	0.56	0.98	0.01	FALSE
54	ROSMAP	Brain Pre-frontal Cortex	SLC38A3	0.03	0.03	lasso	5	0.02	6.4e-04	-5.1	5.2	2.4e-07	0.35	0.04	0.96	FALSE
55	ROSMAP	Brain Pre-frontal Cortex	GPX1	0.23	0.25	lasso	10	0.30	1.5e-39	-3.3	-5.6	2.2e-08	-0.68	1.00	0.00	FALSE
56	YFS	Blood	APEH	0.11	0.05	enet	46	0.06	1.3e-19	7.8	5.9	2.8e-09	0.78	0.01	0.99	FALSE
57	YFS	Blood	COL7A1	0.01	0.01	bslmm	247	0.01	8.0e-04	4.8	5.7	1.3e-08	0.51	0.05	0.87	FALSE
58	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	C3orf62	0.04	0.01	enet	7	0.01	2.0e-02	4.8	-5.4	5.8e-08	-0.58	0.01	0.70	FALSE
59	The Cancer Genome Atlas	Breast Invasive Carcinoma	AMIGO3	0.01	0.00	enet	13	0.01	5.7e-03	-1.9	-5.2	1.6e-07	-0.78	0.01	0.49	FALSE
60	The Cancer Genome Atlas	Glioblastoma Multiforme	AMIGO3	0.18	0.02	enet	24	0.07	2.9e-03	-1.9	-6.2	4.8e-10	-0.69	0.02	0.25	FALSE
61	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	APEH	0.02	0.02	blup	49	0.02	2.5e-03	7.6	7.5	5.5e-14	0.95	0.01	0.89	FALSE
62	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	UBA7	0.02	0.02	blup	30	0.02	3.8e-03	-4.9	5.4	6.5e-08	0.68	0.01	0.78	FALSE
63	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	UBA7	0.13	0.16	lasso	6	0.15	1.1e-08	-5.0	5.4	5.9e-08	0.70	0.02	0.98	FALSE
64	The Cancer Genome Atlas	Brain Lower Grade Glioma	C3orf62	0.02	0.00	blup	31	0.02	6.4e-03	-3.5	-5.9	2.8e-09	-0.68	0.01	0.39	FALSE
65	The Cancer Genome Atlas	Brain Lower Grade Glioma	TRAIP	0.02	0.01	enet	8	0.01	3.1e-02	-4.8	-5.5	4.0e-08	-0.57	0.02	0.62	FALSE
66	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	UBA7	0.02	0.01	blup	30	0.02	5.3e-03	-5.1	5.2	1.6e-07	0.63	0.01	0.86	FALSE
67	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	UBA7	0.11	0.14	enet	7	0.11	2.7e-05	-5.1	5.2	1.9e-07	0.66	0.02	0.98	FALSE
68	The Cancer Genome Atlas	Thyroid Carcinoma	APEH	0.04	0.03	lasso	2	0.03	3.9e-04	5.7	6.2	7.4e-10	0.75	0.04	0.77	FALSE