Best TWAS P=5.79e-11 · Best GWAS P=2.49e-15 conditioned to 0.513
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | ROSMAP | Brain Pre-frontal Cortex | NKIRAS1 | 0.10 | 0.07 | enet | 16 | 0.07 | 2.5e-09 | -4.6 | -6.1 | 1.1e-09 | 0.66 | 0.97 | 0.03 | FALSE |
| 2 | YFS | Blood | NKIRAS1 | 0.02 | 0.02 | lasso | 2 | 0.02 | 1.4e-06 | 4.8 | -5.2 | 1.6e-07 | 0.53 | 0.31 | 0.67 | TRUE |
| 3 | The Cancer Genome Atlas | Breast Invasive Carcinoma | NKIRAS1 | 0.02 | 0.01 | blup | 60 | 0.01 | 6.9e-04 | 3.1 | -5.7 | 1.0e-08 | 0.66 | 0.10 | 0.12 | FALSE |
| 4 | The Cancer Genome Atlas | Breast Invasive Carcinoma | RPL15 | 0.04 | 0.02 | blup | 44 | 0.02 | 2.1e-04 | -6.5 | -5.7 | 1.2e-08 | 0.68 | 0.25 | 0.56 | FALSE |
| 5 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NKIRAS1 | 0.14 | 0.05 | blup | 60 | 0.06 | 7.0e-07 | -5.5 | -6.3 | 4.1e-10 | 0.74 | 0.40 | 0.59 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | NR1D2 | 0.03 | 0.02 | enet | 4 | 0.04 | 5.5e-05 | -7.3 | -6.5 | 5.8e-11 | 0.74 | 0.01 | 0.93 | TRUE |
| 7 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | NR1D2 | 0.08 | 0.01 | enet | 6 | 0.02 | 1.2e-02 | -5.9 | -6.5 | 9.7e-11 | 0.80 | 0.01 | 0.91 | FALSE |
| 8 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | RPL15 | 0.14 | 0.06 | lasso | 4 | 0.05 | 1.8e-04 | -5.8 | -6.4 | 1.6e-10 | 0.72 | 0.05 | 0.82 | FALSE |
| 9 | The Cancer Genome Atlas | Ovarian Serous Cystadenocarcinoma | UBE2E1 | 0.08 | 0.03 | lasso | 2 | 0.03 | 2.3e-03 | -6.2 | -6.3 | 3.2e-10 | 0.73 | 0.03 | 0.77 | FALSE |