Hub : Genes

UBE2E1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Kidney Renal Papillary Cell Carcinoma	0.066	0.033	0.0021	0.025	0.031	0.030	NA	0.028	0.0130	0.00660	0.0080	NA	0.0091
2	TCGA	Liver Hepatocellular Carcinoma	0.169	0.077	0.0067	0.015	0.065	0.042	NA	0.007	0.0600	0.00055	0.0045	NA	0.1400
3	TCGA	Ovarian Serous Cystadenocarcinoma	0.081	0.046	0.0038	0.031	0.029	0.029	NA	0.034	0.0032	0.00430	0.0044	NA	0.0023

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.7	1.1	3.1	0.0	-0.4	-1.8
Bipolar Disorder or Schizophrenia	0.4	0.9	2.5	0.1	1.6	0.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.4	0.4	-0.7	-0.0
Depression (Nagel 2018)	0.2	0.2	0.7	0.0	-0.8	-0.1
Intelligence (Savage-Jansen 2018)	6.3	19.4	44.9	-0.2	-3.6	-6.7
Neuroticism (Nagel 2018)	0.1	0.3	0.7	0.5	-0.8	-0.2
Schizophrenia (2018)	1.6	3.3	5.6	0.1	2.4	2.1
Schizophrenia vs Biploar Disorder	1.0	1.3	2.8	0.0	1.1	1.7
Worry (Nagel 2018)	0.4	0.7	2.1	0.1	-1.5	-0.3
Alzheimer’s Disease (in mother)	0.9	1.0	3.0	1.7	0.3	-0.1
Alzheimer’s Disease (in father)	0.1	0.2	0.3	-0.5	-0.4	0.2
Alzheimer’s Disease (including proxy)	0.8	1.2	2.0	1.4	0.9	0.9
Crohns Disease (2017)	0.5	1.2	2.8	-1.7	0.2	-0.9
Irritable Bowel Disease (IBD)	0.1	0.2	0.5	-0.4	0.7	-0.1
Ulcerative Colitis (UC)	0.4	0.8	2.4	1.5	0.3	0.2
Major Depression (MDD)	0.7	0.9	0.9	-0.9	0.9	-1.0
Reaction Time	1.2	2.3	3.7	0.9	1.5	1.9
Verbal and Numeric Reasoning (VNR)	7.0	16.8	39.6	-0.0	-3.3	-6.3
Breast Cancer	0.1	0.2	0.5	-0.2	-0.1	0.7
Ovarian Cancer	0.6	0.8	1.7	-1.3	0.3	-0.8
Prostate Cancer	2.4	3.3	6.9	1.7	-2.6	-0.4
Age at First Birth	2.3	3.3	6.7	1.4	-2.6	1.1
Bipolar Disorder (2011)	0.9	0.9	1.3	1.0	-0.4	-1.1
Body Mass Index (BMI) (2010)	0.3	0.4	0.8	-0.3	0.9	0.7
Coronary Artery Disease (CAD)	0.9	1.1	3.0	0.1	1.7	0.5
Crohns Disease (2012)	1.4	2.3	4.4	-2.1	0.8	-1.4
Mean Putamen Volume	1.7	1.9	4.8	0.9	-0.3	2.2
Fasting Glucose	0.1	0.2	0.4	-0.6	0.3	-0.2
HbA1C	4.3	4.8	7.9	1.5	2.8	2.1
HDL Cholesterol	0.1	0.1	0.3	-0.0	-0.2	-0.6
LDL Cholesterol	0.6	0.9	2.4	-0.5	1.5	-0.3
Lupus	0.1	0.1	0.2	0.1	-0.4	0.4
Neuroticism (2016)	0.7	1.0	1.8	-1.1	-1.4	-0.4
Primary Biliary Cirrhosis	1.1	1.5	2.9	-0.6	1.2	1.7
Rheumatoid Arthritis	1.2	1.7	3.5	-1.9	-0.3	-1.2
Schizophrenia (2014)	1.4	3.0	5.6	-0.2	2.4	1.8
Triglycerides	0.3	0.5	0.7	-0.8	0.8	0.6
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.8	0.3	-0.0	-0.9
Ulcerative Colitis	0.4	0.6	1.4	0.6	1.2	-0.4
Blood Eosinophil Count	0.6	4.6	7.3	2.4	0.7	2.7
Blood Platelet Count	0.4	4.5	8.5	0.3	2.9	2.2
Blood Red Count	0.1	1.2	2.6	-1.6	-0.4	-1.0
Blood White Count	0.4	2.9	7.0	0.8	2.6	0.9
Heel T-Score	0.4	3.1	7.8	2.8	-0.9	0.8
BMI	0.1	0.5	0.9	-0.6	0.7	0.9
Height	0.5	9.9	24.8	-1.3	-1.8	-5.0
Waist Hip Ratio (WHR)	0.3	1.3	2.2	-1.5	1.4	0.2
Systolic Blood Pressure	0.2	1.1	1.7	-0.6	-1.3	-1.0
Smoking Status	0.8	2.0	3.2	-1.8	1.4	0.9
Allergy or Eczema	0.8	2.2	2.7	1.2	1.6	1.7
Cardiovascular Disease	0.0	0.1	0.2	-0.3	-0.2	0.4
Hypothyroidism (self reported)	0.2	0.4	0.9	-0.9	-0.3	0.5
Respiratory disease	2.1	4.6	9.8	1.7	1.1	3.1
Type 2 Diabetes (T2D) (2018)	1.3	2.5	6.2	-2.5	0.6	-1.0
Lung FEV1/FVC ratio	0.9	4.7	13.8	-0.1	0.4	-3.7
Lung FVC	0.2	1.3	3.3	1.8	-0.6	0.4
Neuroticism	0.3	0.6	1.0	-0.1	-1.0	-0.9
Chronotype (morning person)	0.8	1.9	5.3	0.5	-2.3	0.0
Hair Pigment	0.1	2.1	5.6	-2.4	0.7	-0.5
Tanning	0.1	1.1	2.2	-0.1	-1.5	1.0
Hand grip strength (left)	0.5	1.4	1.9	-1.0	-1.2	-1.4
Number of treatments/medications taken	0.7	1.2	1.8	0.3	1.3	1.3
Average weekly spirits intake	1.0	1.2	2.5	-0.6	1.6	0.8
Sensitivity / hurt feelings	0.8	1.4	3.7	-1.9	-0.8	0.2
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.0	0.0	0.1	0.2
Hearing difficulty/problems: Yes	0.9	1.4	2.0	1.4	0.6	1.3
Relative age of first facial hair	0.2	0.5	0.9	-0.9	0.8	-0.0
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	2.9	-0.3	-1.3	-1.7
Ever used hormone-replacement therapy (HRT)	0.8	1.0	2.0	1.0	-1.4	0.1
Ever had hysterectomy (womb removed)	0.4	0.4	0.9	0.5	0.1	1.0
Systolic blood pressure, automated reading	0.7	2.0	4.1	-0.7	-2.0	-1.1
Eye problems/disorders: Diabetes related eye disease	0.9	1.0	1.6	-1.2	-0.5	-1.1
Angina	0.8	1.0	2.5	-0.7	1.6	0.4
Medication for hormone replacement therapy	0.9	1.0	2.1	-0.9	1.4	-0.2
Vitamin and mineral supplements	0.2	0.3	0.5	-0.5	0.7	0.5
Supplements: Zinc	1.8	2.0	2.7	-0.8	-1.6	-1.6
Medication: Co-codamol	0.7	0.9	1.7	-1.3	0.6	0.7
Medication: Metformin	2.5	3.5	6.0	-2.4	-0.1	-2.1
Diabetes (father)	2.6	3.3	7.2	2.7	0.7	1.4
Diabetes (mother)	1.9	2.4	4.2	-1.7	-0.6	-2.0
Severe depression (siblings)	2.3	2.5	7.3	0.2	2.7	0.6
Pack years adult smoking proportion	2.1	3.2	4.8	-0.6	2.2	2.1
Impedance of leg (right)	1.0	4.7	9.4	0.2	3.1	2.1
Leg fat-free mass (left)	0.6	3.2	7.2	-0.9	-1.3	-2.7
Trunk fat percentage	0.8	3.2	7.8	-2.8	1.3	-0.5
Hand grip strength (right)	0.5	1.4	2.2	-0.3	-1.5	-1.4
Townsend deprivation index at recruitment	0.7	1.0	1.6	1.1	0.0	1.3
Current tobacco smoking	0.5	0.9	1.6	-0.1	1.0	1.3
Average weekly fortified wine intake	1.0	1.2	3.0	1.7	-0.7	0.2
Maternal smoking around birth	2.4	3.4	6.3	-0.9	2.5	1.8
Fed-up feelings	0.1	0.1	0.3	-0.2	0.6	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.1	-0.2	-0.3	0.0
Relative age voice broke	0.2	0.4	0.6	-0.6	-0.3	-0.8
Taking other prescription medications	0.7	1.1	1.9	0.3	1.2	1.4
Age when periods started (menarche)	2.5	5.9	9.2	-3.0	-0.6	-2.9
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	0.7	0.0	-0.8	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	1.8	0.2	-1.3	-0.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.6	0.3	-0.1	0.7
Qualifications: CSEs or equivalent	3.9	5.2	9.8	1.0	2.2	3.1
Serious illness, injury or assault to yourself	1.0	1.2	2.3	-0.9	-0.6	1.5
High blood pressure	0.4	1.0	1.5	-1.2	-1.0	-0.7
Hayfever, allergic rhinitis or eczema	1.3	2.9	3.7	1.8	1.3	1.9
Multivitamins +/- minerals	0.2	0.3	0.5	0.3	-0.5	-0.7
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.4	0.8	0.1
Supplements: Glucosamine	0.1	0.2	0.2	-0.5	0.0	0.5
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.4	-0.3	-1.0	1.6
Medication: Atenolol	0.8	1.0	1.6	0.9	-1.3	-0.8
Medication: Levothyroxine sodium	0.9	1.5	2.7	-0.7	-1.6	-1.1
Sitting height	0.5	3.8	7.8	0.8	-1.7	-2.8
Chronic bronchitis/emphysema (father)	1.3	1.5	4.2	-2.0	-0.5	-0.2
High blood pressure (mother)	1.6	2.2	4.0	-0.1	-2.0	-1.6
Body mass index (BMI)	0.2	1.1	3.1	-1.8	0.0	-0.3
Impedance of leg (left)	0.9	4.3	7.1	0.3	2.7	2.4
Leg predicted mass (left)	0.6	3.1	7.0	-1.0	-1.1	-2.6
Trunk fat mass	0.7	3.1	7.2	-2.7	0.8	-1.2
Waist circumference	0.7	2.5	5.8	-2.4	0.5	-1.1
Number of incorrect matches in round	0.3	0.5	0.9	-1.0	0.3	0.7
Past tobacco smoking	0.3	0.6	1.6	1.3	-0.1	0.5
Alcohol usually taken with meals	2.8	4.5	10.6	-1.7	0.6	-3.3
Nervous feelings	0.3	0.5	1.0	-0.6	-1.0	0.3
Frequency of tenseness / restlessness in last 2 weeks	0.0	0.1	0.2	0.4	0.1	-0.1
Hearing difficulty/problems with background noise	1.0	1.5	2.9	-0.6	1.1	1.7
Hair/balding pattern: Pattern 2	0.8	1.0	2.9	0.1	-0.4	-1.7
Had menopause	1.0	1.3	2.1	-0.7	-1.1	-1.4
Had other major operations	0.3	0.3	0.6	0.8	0.0	-0.7
Forced vital capacity (FVC)	0.4	1.4	2.4	1.5	0.9	-1.0
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.5	2.3	-0.6	-1.5	-1.4
Ever unenthusiastic/disinterested for a whole week	0.7	0.8	2.4	1.5	-0.1	0.4
Qualifications: None of the above	1.0	2.1	4.6	-2.1	-0.5	1.3
Financial difficulties in last 2 years	0.4	0.5	1.1	0.6	-0.2	1.1
Mouth/teeth dental problems	0.4	0.6	1.1	1.0	0.5	-0.7
Heart attack	0.7	0.9	1.9	-0.1	1.4	0.8
Allergy	2.1	4.9	6.9	-2.3	-1.5	-2.6
Pain all over the body in last month	1.5	1.6	3.1	1.8	0.1	1.3
Diabetes (self-reported)	3.6	5.6	12.3	-3.5	1.3	-1.7
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	1.8	1.3	0.4	1.0
Medication: Ramipril	0.9	1.2	1.5	-1.0	-1.2	-1.0
Medication: Simvastatin	0.6	0.9	2.6	-0.2	1.6	0.4
Fluid intelligence score	5.7	11.9	26.8	-0.6	-2.9	-5.2
Illnesses of siblings	0.3	0.4	0.8	0.2	0.5	0.9
Neuroticism score	0.3	0.6	0.9	-0.8	-0.4	-1.0
Weight	0.6	2.8	4.8	-1.8	-0.3	-2.2
Impedance of arm (right)	0.5	2.5	6.2	-0.6	2.5	0.8
Arm fat percentage (right)	0.7	2.6	7.2	-2.7	0.8	-0.1
Trunk fat-free mass	0.6	3.2	8.4	-0.3	-1.0	-2.9
Hip circumference	0.5	2.2	3.6	-1.6	-0.6	-1.9
Time employed in main current job	0.2	0.3	0.7	-0.8	-0.3	0.2
Alcohol intake versus 10 years previously	0.2	0.2	0.5	0.4	0.7	-0.3
Father’s age at death	0.2	0.2	0.4	0.0	0.5	0.6
Worrier / anxious feelings	0.2	0.4	1.2	0.1	-1.1	0.1
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.1	0.5	0.3
Falls in the last year	2.4	3.2	5.0	-2.0	-2.2	-0.7
Hair/balding pattern: Pattern 3	0.2	0.4	1.0	-0.0	-1.0	-0.2
Number of live births	0.6	0.8	2.1	-1.4	-0.1	0.6
Forced expiratory volume in 1-second (FEV1)	0.6	1.9	3.1	1.4	0.7	-1.8
Pulse rate	3.6	6.0	10.5	-1.8	3.2	2.1
Happiness	3.1	3.8	6.6	2.6	1.4	1.6
Noisy workplace	0.1	0.1	0.2	-0.5	-0.0	0.2
Qualifications: A levels/AS levels or equivalent	1.5	3.3	8.4	-0.2	-1.2	-2.9
Serious illness, injury or assault of a close relative in last 2 years	1.9	2.1	3.4	-0.2	-1.8	-1.7
Mouth/teeth dental problems: Dentures	1.0	1.7	2.7	-1.6	-1.5	-0.6
Asthma	0.8	1.6	3.4	0.8	0.9	1.8
Medication: Ibuprofen (e.g. Nurofen)	1.6	2.0	3.5	1.9	-0.1	1.6
Medication: Cholesterol lowering	0.1	0.1	0.2	0.4	0.1	-0.2
Depression (self-reported)	0.1	0.2	0.3	0.3	0.4	0.5
Medication: Lansoprazole	1.7	1.9	3.4	-0.9	1.8	1.2
Prospective memory result	1.0	1.2	3.7	-0.2	-0.0	1.9
Lung cancer (father)	2.4	2.8	5.3	-2.3	1.4	-1.1
Illnesses of mother	0.5	0.6	1.1	-0.0	1.0	0.9
Forced expiratory volume in 1-second (FEV1), Best measure	0.5	1.6	3.1	1.2	-0.5	-1.8
Pulse wave Arterial Stiffness index	2.4	2.8	4.3	-2.1	-1.2	-1.6
Impedance of arm (left)	0.5	2.1	6.1	-0.4	2.5	0.4
Arm fat mass (right)	0.7	2.7	6.6	-2.6	0.3	-1.2
Trunk predicted mass	0.6	3.3	8.7	-0.4	-1.0	-3.0
Standing height	0.7	6.8	19.6	-0.5	-0.8	-4.4
Length of working week for main job	2.0	2.2	4.2	1.0	-1.1	-2.0
Exposure to tobacco smoke at home	0.3	0.3	0.9	0.1	-0.3	-1.0
Breastfed as a baby	0.1	0.2	0.2	-0.5	-0.4	0.3
Tense / ‘highly strung’	0.3	0.5	1.3	-1.1	0.5	0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	1.5	2.3	3.5	-1.9	0.9	-1.6
Hair/balding pattern: Pattern 4	0.2	0.4	0.6	-0.5	0.6	-0.8
Birth weight of first child	0.2	0.3	0.7	-0.8	-0.5	-0.1
Peak expiratory flow (PEF)	0.7	1.7	2.8	1.4	-0.4	-1.7
Pulse wave reflection index	3.9	4.8	12.2	-0.6	-3.5	-1.4
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.3	0.5	1.5	1.1
Loud music exposure frequency	0.8	0.8	1.6	1.3	-0.6	0.7
Qualifications: O levels/GCSEs or equivalent	0.4	0.7	1.1	1.1	0.8	-0.4
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	1.3	-0.2	1.1	0.8
Blood clot in the leg (DVT)	0.7	0.9	1.2	0.9	-1.1	-0.7
Medication: Paracetamol	0.1	0.1	0.4	0.1	-0.6	0.2
Headache pain in last month	0.2	0.4	0.6	0.5	0.5	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.4	0.6	1.2	0.2
Glaucoma (self-reported)	0.3	0.4	0.7	0.2	0.9	0.6
Gout (self-reported)	0.0	0.0	0.0	-0.1	-0.2	-0.2
Hypothyroidism/myxoedema (self-reported)	0.9	1.8	2.5	-1.3	-1.6	-1.2
Medication: Amlodipine	0.5	0.7	1.5	-0.7	-0.2	-1.2
Medication: Ventolin 100micrograms inhaler	1.1	1.4	3.9	-0.3	2.0	-0.2
Birth weight	1.5	3.2	5.1	-1.6	1.3	-2.3
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.8	0.7	-0.1	0.9
High blood pressure (siblings)	0.3	0.4	0.8	-0.2	-0.5	-0.9
Forced vital capacity (FVC), Best measure	0.3	1.1	2.4	1.6	-0.1	-0.9
Body fat percentage	0.7	2.9	7.3	-2.7	1.1	-0.2
Leg fat percentage (right)	0.5	1.9	4.2	-2.0	1.0	0.7
Arm fat-free mass (right)	0.6	3.3	7.5	-0.4	-1.5	-2.7
Exposure to tobacco smoke outside home	0.7	0.9	2.5	1.6	0.4	-0.3
Comparative body size at age 10	0.9	2.6	4.7	1.7	-2.2	-0.4
Number of full brothers	0.9	1.2	2.1	-1.1	1.5	-0.5
Worry too long after embarrassment	0.2	0.3	0.6	-0.8	0.0	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	5.2	-1.0	0.0	-2.3
Wheeze or whistling in the chest in last year	1.6	2.9	5.3	0.9	1.6	2.3
Number of children fathered	4.8	5.4	9.2	-2.5	3.0	0.9
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	4.8	0.5	-2.2	0.5
Age at first live birth	0.4	0.7	1.6	0.2	-1.3	-0.6
Pulse wave peak to peak time	1.8	2.2	3.8	1.9	1.0	1.3
Health satisfaction	0.5	0.6	1.4	-0.4	1.2	-0.4
Shortness of breath walking on level ground	2.5	3.0	5.8	0.3	2.4	1.8
Qualifications: College or University degree	2.9	9.3	18.9	-0.7	-2.9	-4.3
Eye problems/disorders: None of the above	0.5	0.5	1.4	-0.1	1.2	0.4
Mouth/teeth dental problems: Loose teeth	0.3	0.4	1.1	0.2	-1.1	-0.3
Emphysema/chronic bronchitis	1.0	1.1	1.7	-0.2	1.2	1.3
Medication for pain relief, constipation, heartburn	1.0	1.6	4.0	-1.0	-0.0	-2.0
Neck or shoulder pain in last month	1.6	2.3	5.0	-1.2	2.2	-0.6
Medication: Blood pressure	0.7	1.2	3.0	-0.9	-1.7	-0.1
Angina (self-reported)	0.9	1.1	2.9	-0.7	1.7	0.3
Migraine (self-reported)	1.2	1.5	4.0	-0.5	-2.0	-0.3
Medication: Ibuprofen	1.9	2.2	4.3	2.1	-0.4	1.5
Medication: Allopurinol	0.0	0.0	0.1	0.3	0.1	0.1
Medication: Omeprazole	1.3	1.5	2.5	-1.5	1.6	0.1
Medication: Seretide 50 evohaler	2.9	3.3	4.5	1.5	2.1	1.8
Mean time to correctly identify matches	0.7	1.3	2.4	0.8	1.0	1.6
Heart disease (mother)	0.8	1.0	1.9	0.5	-1.4	0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.6	0.8	0.7	0.5
Whole body fat mass	0.6	2.4	5.8	-2.4	0.7	-1.0
Leg fat mass (right)	0.4	1.6	4.3	-2.1	0.5	-0.4
Arm predicted mass (right)	0.7	3.8	8.2	-0.5	-1.7	-2.9
Pulse rate, automated reading	2.5	8.0	19.4	-4.4	1.9	-1.0
Alcohol intake frequency.	0.1	0.3	0.8	-0.0	-0.1	-0.9
Comparative height size at age 10	0.5	2.7	8.0	2.8	-0.2	-0.3
Number of full sisters	0.7	0.9	1.5	-0.5	1.0	1.2
Suffer from ‘nerves’	1.8	2.8	4.5	-1.4	-1.4	-2.1
Overall health rating	0.3	0.7	1.4	-1.2	-0.5	-0.6
Chest pain or discomfort	0.4	0.6	0.9	0.9	0.4	1.0
Had major operations	0.6	0.7	1.2	-0.4	1.1	-0.9
Age at last live birth	1.7	2.5	3.9	-2.0	-0.1	-1.9
Family relationship satisfaction	0.4	0.5	0.8	0.7	0.9	0.5
Leg pain on walking	0.3	0.4	0.5	-0.7	0.7	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.7	0.8	1.7	-0.5	1.3	0.7
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.6	-0.7	-0.0	0.7
Illness, injury, bereavement, stress in last 2 years	0.5	0.6	1.4	0.5	1.2	0.3
Medication: Aspirin	0.3	0.4	0.9	0.3	-0.5	1.0
Supplements: Vitamin C	0.8	1.0	1.5	0.1	-1.2	-1.2
Knee pain experienced in last month	0.8	1.3	2.3	-1.5	0.5	1.1
Hypertension (Self-reported)	0.3	0.9	1.3	-1.1	-0.9	-0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.3	1.5	2.6	-0.5	1.3	1.6
Illnesses of father: Heart disease	0.2	0.3	0.6	0.3	-0.3	-0.8
Illnesses of siblings: Diabetes	0.3	0.4	0.7	-0.6	0.9	-0.2
Smoking status: Previous	0.9	1.4	3.2	-1.8	-0.6	-0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	4.3	-0.5	-0.8	-2.1
Whole body fat-free mass	0.6	3.6	8.7	-0.6	-1.3	-3.0
Leg fat-free mass (right)	0.7	4.0	8.7	-0.9	-1.6	-2.9
Arm fat percentage (left)	0.6	2.3	6.2	-2.5	0.8	-0.3
Average weekly red wine intake	0.2	0.3	0.6	0.5	-0.1	-0.8
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	-0.8	-0.2	0.7
Mood swings	0.1	0.2	0.6	-0.3	0.8	0.0
Loneliness, isolation	0.6	0.9	2.2	0.3	-0.7	-1.5
Long-standing illness, disability or infirmity	0.9	1.4	1.9	-1.4	0.8	-1.3
Ever had bowel cancer screening	0.2	0.3	0.6	-0.4	-0.8	0.2
Diabetes diagnosed by doctor	3.7	6.0	13.2	-3.6	1.5	-1.6
Ever had stillbirth, spontaneous miscarriage or termination	1.5	1.6	3.9	-0.9	2.0	0.4
Friendships satisfaction	1.3	1.6	2.8	1.7	1.4	-0.4
Qualifications: nursing, teaching	2.0	3.0	7.8	-0.9	-0.7	-2.8
Commuting to job workplace: Walk	0.9	1.0	2.5	1.6	-0.6	-0.3
Eye problems/disorders: Cataract	0.5	0.5	1.3	1.1	-0.4	-0.3
Mouth/teeth dental problems: Mouth ulcers	1.3	2.1	4.5	1.3	0.5	2.1
Medication for cholesterol	0.3	0.4	0.7	0.7	-0.9	-0.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.7	0.8	1.0	1.0	-0.6	0.9
Back pain experienced in last month	0.1	0.1	0.2	-0.4	-0.2	-0.2
Mineral and other dietary supplements	0.3	0.4	0.8	-0.5	0.9	-0.4
Breast cancer (self-reported)	0.6	0.7	1.1	0.9	-1.1	-0.3
Asthma (self-reported)	0.9	1.8	3.3	1.1	0.9	1.8
Osteoporosis (self-reported)	1.2	1.5	4.2	-2.0	0.1	-0.7
Osteoarthritis (self-reported)	0.2	0.3	0.4	-0.7	-0.6	0.3
Medication: Aspirin	0.1	0.1	0.2	-0.3	-0.4	0.3
Medication: Gliclazide	1.5	1.7	3.1	-1.8	-0.4	-1.4
Illnesses of father: None of the above (group 1)	0.4	0.5	0.9	-0.5	-0.5	-1.0
Smoking status: Current	0.5	0.8	1.1	-0.4	1.0	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	2.3	1.5	0.1	-0.1
Whole body water mass	0.7	3.9	9.4	-0.7	-1.4	-3.1
Leg predicted mass (right)	0.8	4.1	9.0	-0.9	-1.6	-3.0
Arm fat mass (left)	0.7	2.9	6.9	-2.6	0.3	-1.3
Number of self-reported non-cancer illnesses	0.2	0.3	0.4	0.6	0.2	0.7
Average weekly champagne plus white wine intake	0.5	0.7	2.0	1.4	-0.4	0.1
Miserableness	0.1	0.1	0.3	-0.1	0.1	-0.5
Guilty feelings	0.5	0.7	0.9	-0.5	1.0	-1.0
Wears glasses or contact lenses	1.7	2.0	2.9	-1.7	-0.5	-1.7
Ever taken oral contraceptive pill	0.9	1.0	2.2	1.0	1.5	0.1
Hearing aid user	0.6	0.7	1.7	1.3	0.6	0.1
Mother’s age at death	0.4	0.5	0.8	0.7	-0.6	-0.9
Financial situation satisfaction	0.8	1.0	2.8	0.1	1.7	0.3
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.3	0.0	-0.7	1.5
Commuting to job workplace: Public transport	0.7	0.9	2.0	0.3	-0.7	-1.4
Eye problems/disorders: Glaucoma	0.6	0.8	2.0	0.4	0.3	1.4
Medication: Blood pressure	0.0	0.0	0.1	0.0	-0.1	-0.3
Pain type(s) experienced in last month: Hip pain	0.5	0.7	1.2	-0.6	1.1	-0.7
Supplements: Fish oil (including cod liver oil)	0.9	1.2	1.8	1.3	-1.4	0.3
High cholesterol (Self-reported)	0.1	0.2	0.4	0.5	-0.6	0.3
Medication: Bendroflumethiazide	0.2	0.3	0.6	-0.4	-0.8	-0.4
Medication: Paracetamol	0.3	0.4	1.0	-1.0	-0.3	-0.5
Medication: Lisinopril	1.3	1.7	4.5	-0.1	2.1	0.8
Medication: Atorvastatin	0.6	0.8	1.4	-1.0	-0.2	-1.2
Illnesses of father: High blood pressure	0.0	0.0	0.1	-0.1	0.3	0.2
Alcohol drinker status: Never	0.2	0.2	0.5	0.1	-0.3	0.7
Ever smoked	0.1	0.1	0.3	-0.2	-0.1	-0.5
Basal metabolic rate	0.6	3.3	7.8	-1.0	-1.1	-2.8
Leg fat percentage (left)	0.5	1.8	4.3	-2.1	0.7	0.7
Arm fat-free mass (left)	0.7	3.3	6.8	-1.0	-1.4	-2.6
Number of operations (self-reported)	0.2	0.3	0.5	-0.7	0.6	0.1
Average weekly beer plus cider intake	0.2	0.3	0.7	0.9	-0.2	0.3
Irritability	0.8	1.4	3.3	-0.8	0.6	-1.8
Risk taking	0.6	0.9	2.2	-1.5	-0.6	0.4
Ever had prostate specific antigen (PSA) test	1.2	1.4	2.5	1.3	0.1	1.6
Fractured/broken bones in last 5 years	0.6	0.8	2.2	-0.3	0.1	-1.5
Age started oral contraceptive pill	0.5	0.6	1.2	-1.1	-0.8	-0.2
Diastolic blood pressure, automated reading	0.1	0.3	0.7	-0.8	-0.2	0.5
Ever depressed for a whole week	0.3	0.4	1.0	0.3	1.0	0.0
Unable to work because of sickness or disability	1.2	1.5	3.1	0.5	-1.8	-1.1
Commuting to job workplace: Cycle	1.5	1.8	4.9	2.2	-0.7	0.3
Myopia	0.1	0.2	0.3	-0.6	0.4	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.7	1.0	1.0	0.7	0.7
Cholesterol lowering medication	0.6	0.8	2.1	-1.4	0.5	0.4
Medication: Omeprazole (e.g. Zanprol)	1.4	1.7	3.1	-1.8	1.4	-0.1
Pain experienced in last month	1.0	1.6	3.2	0.1	-1.8	-1.3
Supplements: Calcium	0.2	0.2	0.5	0.3	-0.1	-0.7
Basal cell carcinoma (self-reported)	0.2	0.2	0.6	0.3	-0.1	-0.8
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.0	-0.0	1.4	1.0
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.0	0.8	-1.0	-0.5
Heart disease (siblings)	1.0	1.2	2.1	-0.6	-1.1	-1.4
Alcohol drinker status: Previous	0.8	0.9	2.4	-1.6	0.4	-0.2
Pack years of smoking	1.6	2.3	3.2	-1.1	1.8	1.6
Impedance of whole body	0.6	3.0	7.3	-0.5	2.7	1.2
Leg fat mass (left)	0.4	1.5	4.3	-2.1	0.3	-0.4
Arm predicted mass (left)	0.7	3.8	7.7	-1.0	-1.6	-2.8