Hub : Genes

UBE2E1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 TCGA Kidney Renal Papillary Cell Carcinoma 0.066 0.033 0.0021 0.025 0.031 0.030 NA 0.028 0.0130 0.00660 0.0080 NA 0.0091
2 TCGA Liver Hepatocellular Carcinoma 0.169 0.077 0.0067 0.015 0.065 0.042 NA 0.007 0.0600 0.00055 0.0045 NA 0.1400
3 TCGA Ovarian Serous Cystadenocarcinoma 0.081 0.046 0.0038 0.031 0.029 0.029 NA 0.034 0.0032 0.00430 0.0044 NA 0.0023

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.7 1.1 3.1 0.0 -0.4 -1.8
Bipolar Disorder or Schizophrenia 0.4 0.9 2.5 0.1 1.6 0.5
Depressed Affect (Nagel 2018) 0.1 0.2 0.4 0.4 -0.7 -0.0
Depression (Nagel 2018) 0.2 0.2 0.7 0.0 -0.8 -0.1
Intelligence (Savage-Jansen 2018) 6.3 19.4 44.9 -0.2 -3.6 -6.7
Neuroticism (Nagel 2018) 0.1 0.3 0.7 0.5 -0.8 -0.2
Schizophrenia (2018) 1.6 3.3 5.6 0.1 2.4 2.1
Schizophrenia vs Biploar Disorder 1.0 1.3 2.8 0.0 1.1 1.7
Worry (Nagel 2018) 0.4 0.7 2.1 0.1 -1.5 -0.3
Alzheimer’s Disease (in mother) 0.9 1.0 3.0 1.7 0.3 -0.1
Alzheimer’s Disease (in father) 0.1 0.2 0.3 -0.5 -0.4 0.2
Alzheimer’s Disease (including proxy) 0.8 1.2 2.0 1.4 0.9 0.9
Crohns Disease (2017) 0.5 1.2 2.8 -1.7 0.2 -0.9
Irritable Bowel Disease (IBD) 0.1 0.2 0.5 -0.4 0.7 -0.1
Ulcerative Colitis (UC) 0.4 0.8 2.4 1.5 0.3 0.2
Major Depression (MDD) 0.7 0.9 0.9 -0.9 0.9 -1.0
Reaction Time 1.2 2.3 3.7 0.9 1.5 1.9
Verbal and Numeric Reasoning (VNR) 7.0 16.8 39.6 -0.0 -3.3 -6.3
Breast Cancer 0.1 0.2 0.5 -0.2 -0.1 0.7
Ovarian Cancer 0.6 0.8 1.7 -1.3 0.3 -0.8
Prostate Cancer 2.4 3.3 6.9 1.7 -2.6 -0.4
Age at First Birth 2.3 3.3 6.7 1.4 -2.6 1.1
Bipolar Disorder (2011) 0.9 0.9 1.3 1.0 -0.4 -1.1
Body Mass Index (BMI) (2010) 0.3 0.4 0.8 -0.3 0.9 0.7
Coronary Artery Disease (CAD) 0.9 1.1 3.0 0.1 1.7 0.5
Crohns Disease (2012) 1.4 2.3 4.4 -2.1 0.8 -1.4
Mean Putamen Volume 1.7 1.9 4.8 0.9 -0.3 2.2
Fasting Glucose 0.1 0.2 0.4 -0.6 0.3 -0.2
HbA1C 4.3 4.8 7.9 1.5 2.8 2.1
HDL Cholesterol 0.1 0.1 0.3 -0.0 -0.2 -0.6
LDL Cholesterol 0.6 0.9 2.4 -0.5 1.5 -0.3
Lupus 0.1 0.1 0.2 0.1 -0.4 0.4
Neuroticism (2016) 0.7 1.0 1.8 -1.1 -1.4 -0.4
Primary Biliary Cirrhosis 1.1 1.5 2.9 -0.6 1.2 1.7
Rheumatoid Arthritis 1.2 1.7 3.5 -1.9 -0.3 -1.2
Schizophrenia (2014) 1.4 3.0 5.6 -0.2 2.4 1.8
Triglycerides 0.3 0.5 0.7 -0.8 0.8 0.6
Type 2 Diabetes (T2D) (2012) 0.3 0.3 0.8 0.3 -0.0 -0.9
Ulcerative Colitis 0.4 0.6 1.4 0.6 1.2 -0.4
Blood Eosinophil Count 0.6 4.6 7.3 2.4 0.7 2.7
Blood Platelet Count 0.4 4.5 8.5 0.3 2.9 2.2
Blood Red Count 0.1 1.2 2.6 -1.6 -0.4 -1.0
Blood White Count 0.4 2.9 7.0 0.8 2.6 0.9
Heel T-Score 0.4 3.1 7.8 2.8 -0.9 0.8
BMI 0.1 0.5 0.9 -0.6 0.7 0.9
Height 0.5 9.9 24.8 -1.3 -1.8 -5.0
Waist Hip Ratio (WHR) 0.3 1.3 2.2 -1.5 1.4 0.2
Systolic Blood Pressure 0.2 1.1 1.7 -0.6 -1.3 -1.0
Smoking Status 0.8 2.0 3.2 -1.8 1.4 0.9
Allergy or Eczema 0.8 2.2 2.7 1.2 1.6 1.7
Cardiovascular Disease 0.0 0.1 0.2 -0.3 -0.2 0.4
Hypothyroidism (self reported) 0.2 0.4 0.9 -0.9 -0.3 0.5
Respiratory disease 2.1 4.6 9.8 1.7 1.1 3.1
Type 2 Diabetes (T2D) (2018) 1.3 2.5 6.2 -2.5 0.6 -1.0
Lung FEV1/FVC ratio 0.9 4.7 13.8 -0.1 0.4 -3.7
Lung FVC 0.2 1.3 3.3 1.8 -0.6 0.4
Neuroticism 0.3 0.6 1.0 -0.1 -1.0 -0.9
Chronotype (morning person) 0.8 1.9 5.3 0.5 -2.3 0.0
Hair Pigment 0.1 2.1 5.6 -2.4 0.7 -0.5
Tanning 0.1 1.1 2.2 -0.1 -1.5 1.0
Hand grip strength (left) 0.5 1.4 1.9 -1.0 -1.2 -1.4
Number of treatments/medications taken 0.7 1.2 1.8 0.3 1.3 1.3
Average weekly spirits intake 1.0 1.2 2.5 -0.6 1.6 0.8
Sensitivity / hurt feelings 0.8 1.4 3.7 -1.9 -0.8 0.2
Frequency of depressed mood in last 2 weeks 0.0 0.0 0.0 0.0 0.1 0.2
Hearing difficulty/problems: Yes 0.9 1.4 2.0 1.4 0.6 1.3
Relative age of first facial hair 0.2 0.5 0.9 -0.9 0.8 -0.0
Other serious medical condition/disability diagnosed by doctor 1.2 1.6 2.9 -0.3 -1.3 -1.7
Ever used hormone-replacement therapy (HRT) 0.8 1.0 2.0 1.0 -1.4 0.1
Ever had hysterectomy (womb removed) 0.4 0.4 0.9 0.5 0.1 1.0
Systolic blood pressure, automated reading 0.7 2.0 4.1 -0.7 -2.0 -1.1
Eye problems/disorders: Diabetes related eye disease 0.9 1.0 1.6 -1.2 -0.5 -1.1
Angina 0.8 1.0 2.5 -0.7 1.6 0.4
Medication for hormone replacement therapy 0.9 1.0 2.1 -0.9 1.4 -0.2
Vitamin and mineral supplements 0.2 0.3 0.5 -0.5 0.7 0.5
Supplements: Zinc 1.8 2.0 2.7 -0.8 -1.6 -1.6
Medication: Co-codamol 0.7 0.9 1.7 -1.3 0.6 0.7
Medication: Metformin 2.5 3.5 6.0 -2.4 -0.1 -2.1
Diabetes (father) 2.6 3.3 7.2 2.7 0.7 1.4
Diabetes (mother) 1.9 2.4 4.2 -1.7 -0.6 -2.0
Severe depression (siblings) 2.3 2.5 7.3 0.2 2.7 0.6
Pack years adult smoking proportion 2.1 3.2 4.8 -0.6 2.2 2.1
Impedance of leg (right) 1.0 4.7 9.4 0.2 3.1 2.1
Leg fat-free mass (left) 0.6 3.2 7.2 -0.9 -1.3 -2.7
Trunk fat percentage 0.8 3.2 7.8 -2.8 1.3 -0.5
Hand grip strength (right) 0.5 1.4 2.2 -0.3 -1.5 -1.4
Townsend deprivation index at recruitment 0.7 1.0 1.6 1.1 0.0 1.3
Current tobacco smoking 0.5 0.9 1.6 -0.1 1.0 1.3
Average weekly fortified wine intake 1.0 1.2 3.0 1.7 -0.7 0.2
Maternal smoking around birth 2.4 3.4 6.3 -0.9 2.5 1.8
Fed-up feelings 0.1 0.1 0.3 -0.2 0.6 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.0 0.0 0.1 -0.2 -0.3 0.0
Relative age voice broke 0.2 0.4 0.6 -0.6 -0.3 -0.8
Taking other prescription medications 0.7 1.1 1.9 0.3 1.2 1.4
Age when periods started (menarche) 2.5 5.9 9.2 -3.0 -0.6 -2.9
Bilateral oophorectomy (both ovaries removed) 0.3 0.4 0.7 0.0 -0.8 0.7
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 1.8 0.2 -1.3 -0.7
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.6 0.3 -0.1 0.7
Qualifications: CSEs or equivalent 3.9 5.2 9.8 1.0 2.2 3.1
Serious illness, injury or assault to yourself 1.0 1.2 2.3 -0.9 -0.6 1.5
High blood pressure 0.4 1.0 1.5 -1.2 -1.0 -0.7
Hayfever, allergic rhinitis or eczema 1.3 2.9 3.7 1.8 1.3 1.9
Multivitamins +/- minerals 0.2 0.3 0.5 0.3 -0.5 -0.7
Stomach or abdominal pain in last month 0.2 0.3 0.6 -0.4 0.8 0.1
Supplements: Glucosamine 0.1 0.2 0.2 -0.5 0.0 0.5
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.4 -0.3 -1.0 1.6
Medication: Atenolol 0.8 1.0 1.6 0.9 -1.3 -0.8
Medication: Levothyroxine sodium 0.9 1.5 2.7 -0.7 -1.6 -1.1
Sitting height 0.5 3.8 7.8 0.8 -1.7 -2.8
Chronic bronchitis/emphysema (father) 1.3 1.5 4.2 -2.0 -0.5 -0.2
High blood pressure (mother) 1.6 2.2 4.0 -0.1 -2.0 -1.6
Body mass index (BMI) 0.2 1.1 3.1 -1.8 0.0 -0.3
Impedance of leg (left) 0.9 4.3 7.1 0.3 2.7 2.4
Leg predicted mass (left) 0.6 3.1 7.0 -1.0 -1.1 -2.6
Trunk fat mass 0.7 3.1 7.2 -2.7 0.8 -1.2
Waist circumference 0.7 2.5 5.8 -2.4 0.5 -1.1
Number of incorrect matches in round 0.3 0.5 0.9 -1.0 0.3 0.7
Past tobacco smoking 0.3 0.6 1.6 1.3 -0.1 0.5
Alcohol usually taken with meals 2.8 4.5 10.6 -1.7 0.6 -3.3
Nervous feelings 0.3 0.5 1.0 -0.6 -1.0 0.3
Frequency of tenseness / restlessness in last 2 weeks 0.0 0.1 0.2 0.4 0.1 -0.1
Hearing difficulty/problems with background noise 1.0 1.5 2.9 -0.6 1.1 1.7
Hair/balding pattern: Pattern 2 0.8 1.0 2.9 0.1 -0.4 -1.7
Had menopause 1.0 1.3 2.1 -0.7 -1.1 -1.4
Had other major operations 0.3 0.3 0.6 0.8 0.0 -0.7
Forced vital capacity (FVC) 0.4 1.4 2.4 1.5 0.9 -1.0
Heel bone mineral density (BMD) T-score, automated (right) 0.7 1.5 2.3 -0.6 -1.5 -1.4
Ever unenthusiastic/disinterested for a whole week 0.7 0.8 2.4 1.5 -0.1 0.4
Qualifications: None of the above 1.0 2.1 4.6 -2.1 -0.5 1.3
Financial difficulties in last 2 years 0.4 0.5 1.1 0.6 -0.2 1.1
Mouth/teeth dental problems 0.4 0.6 1.1 1.0 0.5 -0.7
Heart attack 0.7 0.9 1.9 -0.1 1.4 0.8
Allergy 2.1 4.9 6.9 -2.3 -1.5 -2.6
Pain all over the body in last month 1.5 1.6 3.1 1.8 0.1 1.3
Diabetes (self-reported) 3.6 5.6 12.3 -3.5 1.3 -1.7
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 1.8 1.3 0.4 1.0
Medication: Ramipril 0.9 1.2 1.5 -1.0 -1.2 -1.0
Medication: Simvastatin 0.6 0.9 2.6 -0.2 1.6 0.4
Fluid intelligence score 5.7 11.9 26.8 -0.6 -2.9 -5.2
Illnesses of siblings 0.3 0.4 0.8 0.2 0.5 0.9
Neuroticism score 0.3 0.6 0.9 -0.8 -0.4 -1.0
Weight 0.6 2.8 4.8 -1.8 -0.3 -2.2
Impedance of arm (right) 0.5 2.5 6.2 -0.6 2.5 0.8
Arm fat percentage (right) 0.7 2.6 7.2 -2.7 0.8 -0.1
Trunk fat-free mass 0.6 3.2 8.4 -0.3 -1.0 -2.9
Hip circumference 0.5 2.2 3.6 -1.6 -0.6 -1.9
Time employed in main current job 0.2 0.3 0.7 -0.8 -0.3 0.2
Alcohol intake versus 10 years previously 0.2 0.2 0.5 0.4 0.7 -0.3
Father’s age at death 0.2 0.2 0.4 0.0 0.5 0.6
Worrier / anxious feelings 0.2 0.4 1.2 0.1 -1.1 0.1
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.2 0.1 0.5 0.3
Falls in the last year 2.4 3.2 5.0 -2.0 -2.2 -0.7
Hair/balding pattern: Pattern 3 0.2 0.4 1.0 -0.0 -1.0 -0.2
Number of live births 0.6 0.8 2.1 -1.4 -0.1 0.6
Forced expiratory volume in 1-second (FEV1) 0.6 1.9 3.1 1.4 0.7 -1.8
Pulse rate 3.6 6.0 10.5 -1.8 3.2 2.1
Happiness 3.1 3.8 6.6 2.6 1.4 1.6
Noisy workplace 0.1 0.1 0.2 -0.5 -0.0 0.2
Qualifications: A levels/AS levels or equivalent 1.5 3.3 8.4 -0.2 -1.2 -2.9
Serious illness, injury or assault of a close relative in last 2 years 1.9 2.1 3.4 -0.2 -1.8 -1.7
Mouth/teeth dental problems: Dentures 1.0 1.7 2.7 -1.6 -1.5 -0.6
Asthma 0.8 1.6 3.4 0.8 0.9 1.8
Medication: Ibuprofen (e.g. Nurofen) 1.6 2.0 3.5 1.9 -0.1 1.6
Medication: Cholesterol lowering 0.1 0.1 0.2 0.4 0.1 -0.2
Depression (self-reported) 0.1 0.2 0.3 0.3 0.4 0.5
Medication: Lansoprazole 1.7 1.9 3.4 -0.9 1.8 1.2
Prospective memory result 1.0 1.2 3.7 -0.2 -0.0 1.9
Lung cancer (father) 2.4 2.8 5.3 -2.3 1.4 -1.1
Illnesses of mother 0.5 0.6 1.1 -0.0 1.0 0.9
Forced expiratory volume in 1-second (FEV1), Best measure 0.5 1.6 3.1 1.2 -0.5 -1.8
Pulse wave Arterial Stiffness index 2.4 2.8 4.3 -2.1 -1.2 -1.6
Impedance of arm (left) 0.5 2.1 6.1 -0.4 2.5 0.4
Arm fat mass (right) 0.7 2.7 6.6 -2.6 0.3 -1.2
Trunk predicted mass 0.6 3.3 8.7 -0.4 -1.0 -3.0
Standing height 0.7 6.8 19.6 -0.5 -0.8 -4.4
Length of working week for main job 2.0 2.2 4.2 1.0 -1.1 -2.0
Exposure to tobacco smoke at home 0.3 0.3 0.9 0.1 -0.3 -1.0
Breastfed as a baby 0.1 0.2 0.2 -0.5 -0.4 0.3
Tense / ‘highly strung’ 0.3 0.5 1.3 -1.1 0.5 0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 1.5 2.3 3.5 -1.9 0.9 -1.6
Hair/balding pattern: Pattern 4 0.2 0.4 0.6 -0.5 0.6 -0.8
Birth weight of first child 0.2 0.3 0.7 -0.8 -0.5 -0.1
Peak expiratory flow (PEF) 0.7 1.7 2.8 1.4 -0.4 -1.7
Pulse wave reflection index 3.9 4.8 12.2 -0.6 -3.5 -1.4
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.3 0.5 1.5 1.1
Loud music exposure frequency 0.8 0.8 1.6 1.3 -0.6 0.7
Qualifications: O levels/GCSEs or equivalent 0.4 0.7 1.1 1.1 0.8 -0.4
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 1.3 -0.2 1.1 0.8
Blood clot in the leg (DVT) 0.7 0.9 1.2 0.9 -1.1 -0.7
Medication: Paracetamol 0.1 0.1 0.4 0.1 -0.6 0.2
Headache pain in last month 0.2 0.4 0.6 0.5 0.5 0.8
Medication for cholesterol, blood pressure or diabetes 0.4 0.6 1.4 0.6 1.2 0.2
Glaucoma (self-reported) 0.3 0.4 0.7 0.2 0.9 0.6
Gout (self-reported) 0.0 0.0 0.0 -0.1 -0.2 -0.2
Hypothyroidism/myxoedema (self-reported) 0.9 1.8 2.5 -1.3 -1.6 -1.2
Medication: Amlodipine 0.5 0.7 1.5 -0.7 -0.2 -1.2
Medication: Ventolin 100micrograms inhaler 1.1 1.4 3.9 -0.3 2.0 -0.2
Birth weight 1.5 3.2 5.1 -1.6 1.3 -2.3
Chronic bronchitis/emphysema (mother) 0.4 0.4 0.8 0.7 -0.1 0.9
High blood pressure (siblings) 0.3 0.4 0.8 -0.2 -0.5 -0.9
Forced vital capacity (FVC), Best measure 0.3 1.1 2.4 1.6 -0.1 -0.9
Body fat percentage 0.7 2.9 7.3 -2.7 1.1 -0.2
Leg fat percentage (right) 0.5 1.9 4.2 -2.0 1.0 0.7
Arm fat-free mass (right) 0.6 3.3 7.5 -0.4 -1.5 -2.7
Exposure to tobacco smoke outside home 0.7 0.9 2.5 1.6 0.4 -0.3
Comparative body size at age 10 0.9 2.6 4.7 1.7 -2.2 -0.4
Number of full brothers 0.9 1.2 2.1 -1.1 1.5 -0.5
Worry too long after embarrassment 0.2 0.3 0.6 -0.8 0.0 0.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.1 5.2 -1.0 0.0 -2.3
Wheeze or whistling in the chest in last year 1.6 2.9 5.3 0.9 1.6 2.3
Number of children fathered 4.8 5.4 9.2 -2.5 3.0 0.9
Reason for reducing amount of alcohol drunk: Health precaution 1.5 1.7 4.8 0.5 -2.2 0.5
Age at first live birth 0.4 0.7 1.6 0.2 -1.3 -0.6
Pulse wave peak to peak time 1.8 2.2 3.8 1.9 1.0 1.3
Health satisfaction 0.5 0.6 1.4 -0.4 1.2 -0.4
Shortness of breath walking on level ground 2.5 3.0 5.8 0.3 2.4 1.8
Qualifications: College or University degree 2.9 9.3 18.9 -0.7 -2.9 -4.3
Eye problems/disorders: None of the above 0.5 0.5 1.4 -0.1 1.2 0.4
Mouth/teeth dental problems: Loose teeth 0.3 0.4 1.1 0.2 -1.1 -0.3
Emphysema/chronic bronchitis 1.0 1.1 1.7 -0.2 1.2 1.3
Medication for pain relief, constipation, heartburn 1.0 1.6 4.0 -1.0 -0.0 -2.0
Neck or shoulder pain in last month 1.6 2.3 5.0 -1.2 2.2 -0.6
Medication: Blood pressure 0.7 1.2 3.0 -0.9 -1.7 -0.1
Angina (self-reported) 0.9 1.1 2.9 -0.7 1.7 0.3
Migraine (self-reported) 1.2 1.5 4.0 -0.5 -2.0 -0.3
Medication: Ibuprofen 1.9 2.2 4.3 2.1 -0.4 1.5
Medication: Allopurinol 0.0 0.0 0.1 0.3 0.1 0.1
Medication: Omeprazole 1.3 1.5 2.5 -1.5 1.6 0.1
Medication: Seretide 50 evohaler 2.9 3.3 4.5 1.5 2.1 1.8
Mean time to correctly identify matches 0.7 1.3 2.4 0.8 1.0 1.6
Heart disease (mother) 0.8 1.0 1.9 0.5 -1.4 0.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.4 0.4 0.6 0.8 0.7 0.5
Whole body fat mass 0.6 2.4 5.8 -2.4 0.7 -1.0
Leg fat mass (right) 0.4 1.6 4.3 -2.1 0.5 -0.4
Arm predicted mass (right) 0.7 3.8 8.2 -0.5 -1.7 -2.9
Pulse rate, automated reading 2.5 8.0 19.4 -4.4 1.9 -1.0
Alcohol intake frequency. 0.1 0.3 0.8 -0.0 -0.1 -0.9
Comparative height size at age 10 0.5 2.7 8.0 2.8 -0.2 -0.3
Number of full sisters 0.7 0.9 1.5 -0.5 1.0 1.2
Suffer from ‘nerves’ 1.8 2.8 4.5 -1.4 -1.4 -2.1
Overall health rating 0.3 0.7 1.4 -1.2 -0.5 -0.6
Chest pain or discomfort 0.4 0.6 0.9 0.9 0.4 1.0
Had major operations 0.6 0.7 1.2 -0.4 1.1 -0.9
Age at last live birth 1.7 2.5 3.9 -2.0 -0.1 -1.9
Family relationship satisfaction 0.4 0.5 0.8 0.7 0.9 0.5
Leg pain on walking 0.3 0.4 0.5 -0.7 0.7 0.4
Qualifications: NVQ or HND or HNC or equivalent 0.7 0.8 1.7 -0.5 1.3 0.7
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.6 -0.7 -0.0 0.7
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.4 0.5 1.2 0.3
Medication: Aspirin 0.3 0.4 0.9 0.3 -0.5 1.0
Supplements: Vitamin C 0.8 1.0 1.5 0.1 -1.2 -1.2
Knee pain experienced in last month 0.8 1.3 2.3 -1.5 0.5 1.1
Hypertension (Self-reported) 0.3 0.9 1.3 -1.1 -0.9 -0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.3 1.5 2.6 -0.5 1.3 1.6
Illnesses of father: Heart disease 0.2 0.3 0.6 0.3 -0.3 -0.8
Illnesses of siblings: Diabetes 0.3 0.4 0.7 -0.6 0.9 -0.2
Smoking status: Previous 0.9 1.4 3.2 -1.8 -0.6 -0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 4.3 -0.5 -0.8 -2.1
Whole body fat-free mass 0.6 3.6 8.7 -0.6 -1.3 -3.0
Leg fat-free mass (right) 0.7 4.0 8.7 -0.9 -1.6 -2.9
Arm fat percentage (left) 0.6 2.3 6.2 -2.5 0.8 -0.3
Average weekly red wine intake 0.2 0.3 0.6 0.5 -0.1 -0.8
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.6 -0.8 -0.2 0.7
Mood swings 0.1 0.2 0.6 -0.3 0.8 0.0
Loneliness, isolation 0.6 0.9 2.2 0.3 -0.7 -1.5
Long-standing illness, disability or infirmity 0.9 1.4 1.9 -1.4 0.8 -1.3
Ever had bowel cancer screening 0.2 0.3 0.6 -0.4 -0.8 0.2
Diabetes diagnosed by doctor 3.7 6.0 13.2 -3.6 1.5 -1.6
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 3.9 -0.9 2.0 0.4
Friendships satisfaction 1.3 1.6 2.8 1.7 1.4 -0.4
Qualifications: nursing, teaching 2.0 3.0 7.8 -0.9 -0.7 -2.8
Commuting to job workplace: Walk 0.9 1.0 2.5 1.6 -0.6 -0.3
Eye problems/disorders: Cataract 0.5 0.5 1.3 1.1 -0.4 -0.3
Mouth/teeth dental problems: Mouth ulcers 1.3 2.1 4.5 1.3 0.5 2.1
Medication for cholesterol 0.3 0.4 0.7 0.7 -0.9 -0.1
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.7 0.8 1.0 1.0 -0.6 0.9
Back pain experienced in last month 0.1 0.1 0.2 -0.4 -0.2 -0.2
Mineral and other dietary supplements 0.3 0.4 0.8 -0.5 0.9 -0.4
Breast cancer (self-reported) 0.6 0.7 1.1 0.9 -1.1 -0.3
Asthma (self-reported) 0.9 1.8 3.3 1.1 0.9 1.8
Osteoporosis (self-reported) 1.2 1.5 4.2 -2.0 0.1 -0.7
Osteoarthritis (self-reported) 0.2 0.3 0.4 -0.7 -0.6 0.3
Medication: Aspirin 0.1 0.1 0.2 -0.3 -0.4 0.3
Medication: Gliclazide 1.5 1.7 3.1 -1.8 -0.4 -1.4
Illnesses of father: None of the above (group 1) 0.4 0.5 0.9 -0.5 -0.5 -1.0
Smoking status: Current 0.5 0.8 1.1 -0.4 1.0 1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.4 0.8 2.3 1.5 0.1 -0.1
Whole body water mass 0.7 3.9 9.4 -0.7 -1.4 -3.1
Leg predicted mass (right) 0.8 4.1 9.0 -0.9 -1.6 -3.0
Arm fat mass (left) 0.7 2.9 6.9 -2.6 0.3 -1.3
Number of self-reported non-cancer illnesses 0.2 0.3 0.4 0.6 0.2 0.7
Average weekly champagne plus white wine intake 0.5 0.7 2.0 1.4 -0.4 0.1
Miserableness 0.1 0.1 0.3 -0.1 0.1 -0.5
Guilty feelings 0.5 0.7 0.9 -0.5 1.0 -1.0
Wears glasses or contact lenses 1.7 2.0 2.9 -1.7 -0.5 -1.7
Ever taken oral contraceptive pill 0.9 1.0 2.2 1.0 1.5 0.1
Hearing aid user 0.6 0.7 1.7 1.3 0.6 0.1
Mother’s age at death 0.4 0.5 0.8 0.7 -0.6 -0.9
Financial situation satisfaction 0.8 1.0 2.8 0.1 1.7 0.3
Tinnitus: Yes, now most or all of the time 0.8 0.9 2.3 0.0 -0.7 1.5
Commuting to job workplace: Public transport 0.7 0.9 2.0 0.3 -0.7 -1.4
Eye problems/disorders: Glaucoma 0.6 0.8 2.0 0.4 0.3 1.4
Medication: Blood pressure 0.0 0.0 0.1 0.0 -0.1 -0.3
Pain type(s) experienced in last month: Hip pain 0.5 0.7 1.2 -0.6 1.1 -0.7
Supplements: Fish oil (including cod liver oil) 0.9 1.2 1.8 1.3 -1.4 0.3
High cholesterol (Self-reported) 0.1 0.2 0.4 0.5 -0.6 0.3
Medication: Bendroflumethiazide 0.2 0.3 0.6 -0.4 -0.8 -0.4
Medication: Paracetamol 0.3 0.4 1.0 -1.0 -0.3 -0.5
Medication: Lisinopril 1.3 1.7 4.5 -0.1 2.1 0.8
Medication: Atorvastatin 0.6 0.8 1.4 -1.0 -0.2 -1.2
Illnesses of father: High blood pressure 0.0 0.0 0.1 -0.1 0.3 0.2
Alcohol drinker status: Never 0.2 0.2 0.5 0.1 -0.3 0.7
Ever smoked 0.1 0.1 0.3 -0.2 -0.1 -0.5
Basal metabolic rate 0.6 3.3 7.8 -1.0 -1.1 -2.8
Leg fat percentage (left) 0.5 1.8 4.3 -2.1 0.7 0.7
Arm fat-free mass (left) 0.7 3.3 6.8 -1.0 -1.4 -2.6
Number of operations (self-reported) 0.2 0.3 0.5 -0.7 0.6 0.1
Average weekly beer plus cider intake 0.2 0.3 0.7 0.9 -0.2 0.3
Irritability 0.8 1.4 3.3 -0.8 0.6 -1.8
Risk taking 0.6 0.9 2.2 -1.5 -0.6 0.4
Ever had prostate specific antigen (PSA) test 1.2 1.4 2.5 1.3 0.1 1.6
Fractured/broken bones in last 5 years 0.6 0.8 2.2 -0.3 0.1 -1.5
Age started oral contraceptive pill 0.5 0.6 1.2 -1.1 -0.8 -0.2
Diastolic blood pressure, automated reading 0.1 0.3 0.7 -0.8 -0.2 0.5
Ever depressed for a whole week 0.3 0.4 1.0 0.3 1.0 0.0
Unable to work because of sickness or disability 1.2 1.5 3.1 0.5 -1.8 -1.1
Commuting to job workplace: Cycle 1.5 1.8 4.9 2.2 -0.7 0.3
Myopia 0.1 0.2 0.3 -0.6 0.4 -0.2
Vascular/heart problems diagnosed by doctor 0.3 0.7 1.0 1.0 0.7 0.7
Cholesterol lowering medication 0.6 0.8 2.1 -1.4 0.5 0.4
Medication: Omeprazole (e.g. Zanprol) 1.4 1.7 3.1 -1.8 1.4 -0.1
Pain experienced in last month 1.0 1.6 3.2 0.1 -1.8 -1.3
Supplements: Calcium 0.2 0.2 0.5 0.3 -0.1 -0.7
Basal cell carcinoma (self-reported) 0.2 0.2 0.6 0.3 -0.1 -0.8
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.0 -0.0 1.4 1.0
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 1.0 0.8 -1.0 -0.5
Heart disease (siblings) 1.0 1.2 2.1 -0.6 -1.1 -1.4
Alcohol drinker status: Previous 0.8 0.9 2.4 -1.6 0.4 -0.2
Pack years of smoking 1.6 2.3 3.2 -1.1 1.8 1.6
Impedance of whole body 0.6 3.0 7.3 -0.5 2.7 1.2
Leg fat mass (left) 0.4 1.5 4.3 -2.1 0.3 -0.4
Arm predicted mass (left) 0.7 3.8 7.7 -1.0 -1.6 -2.8