TWAS hub - NKIRAS1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Muscle Skeletal	0.1029	0.0390	5.9e-03	0.005	NA	0.010	NA	0.018	8.8e-02	NA	3.0e-02	NA	5.9e-03
2	ROSMAP	Brain Pre-frontal Cortex	0.1031	0.0264	1.5e-07	0.074	0.061	0.070	0.065	0.068	9.5e-10	2.4e-08	2.5e-09	8.5e-09	4.5e-09
3	YFS	Blood	0.0171	0.0070	3.2e-03	0.020	0.007	0.016	0.009	0.017	2.1e-07	1.9e-03	4.4e-06	3.7e-04	1.4e-06
4	TCGA	Breast Invasive Carcinoma	0.0176	0.0122	1.5e-03	0.007	0.013	0.007	NA	0.006	1.4e-02	6.9e-04	1.2e-02	NA	1.4e-02
5	TCGA	Brain Lower Grade Glioma	0.1429	0.0621	7.1e-08	0.047	0.055	0.054	NA	0.054	4.4e-06	7.0e-07	8.3e-07	NA	9.5e-07

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Verbal and Numeric Reasoning (VNR)	11.5	27.6	39.1	1.2	-6.1	-5.2	-5.7	-6.3
Intelligence (Savage-Jansen 2018)	10.1	31.0	48.4	-0.3	-6.4	-5.9	-5.6	-7.0
Fluid intelligence score	9.5	19.7	29.1	1.5	-5.2	-4.4	-4.6	-5.4
Qualifications: CSEs or equivalent	4.4	5.8	10.8	2.2	2.1	2.2	2.1	3.3
Alcohol usually taken with meals	3.9	6.3	13.6	0.4	-3.4	-2.2	-1.0	-3.7
Qualifications: College or University degree	3.8	11.8	18.4	1.5	-4.2	-2.6	-3.8	-4.3
Qualifications: nursing, teaching	3.4	5.3	9.9	2.0	-2.5	-2.3	-1.2	-3.1
Mean Putamen Volume	3.2	3.6	7.2	1.4	2.5	1.1	1.3	2.7
Reaction Time	3.1	6.0	21.6	-0.5	1.3	4.6	0.4	2.5
Qualifications: A levels/AS levels or equivalent	2.9	6.4	12.1	1.9	-3.2	-0.3	-3.5	-2.4
Length of working week for main job	2.9	3.2	10.0	1.3	-1.1	-0.7	-3.2	-1.5
Medication: Ibuprofen (e.g. Nurofen)	2.8	3.5	6.6	0.3	2.6	2.4	0.6	2.2
Medication: Metformin	2.7	3.8	6.4	2.5	-2.2	-1.4	0.2	-2.4
Age when periods started (menarche)	2.7	6.5	13.0	0.3	-3.6	-3.0	0.2	-3.3
Mean time to correctly identify matches	2.7	5.1	16.9	-1.8	1.1	4.1	0.3	2.0
Diabetes diagnosed by doctor	2.7	4.5	7.1	2.7	-2.6	-1.7	1.3	-2.0
Eye problems/disorders: Diabetes related eye disease	2.6	2.8	6.1	2.5	-1.7	-1.6	0.3	-1.5
Diabetes (mother)	2.6	3.4	6.5	-0.4	-2.1	-2.1	-1.0	-2.5
Medication for pain relief, constipation, heartburn	2.6	4.4	8.2	-0.4	-2.9	-2.2	-1.8	-2.4
Forced expiratory volume in 1-second (FEV1), predicted	2.6	5.4	7.1	2.5	-2.0	-2.6	-1.6	-2.7
Wears glasses or contact lenses	2.5	2.8	6.4	-0.8	-2.3	-1.0	-1.0	-2.5
Maternal smoking around birth	2.4	3.4	7.8	1.7	1.3	1.5	2.8	1.5
Age started oral contraceptive pill	2.4	3.0	9.1	-3.0	-0.3	-1.8	1.6	0.3
Respiratory disease	2.3	5.1	9.6	-0.5	3.0	1.1	2.3	3.1
Diverticular disease/diverticulitis (self-reported)	2.3	2.8	4.7	-0.4	2.1	2.2	0.8	1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	2.3	3.0	5.3	0.4	-2.3	-2.0	-0.9	-2.2
Medication: Seretide 50 evohaler	2.3	2.6	7.0	-0.2	1.0	2.7	-0.3	2.2
HbA1C	2.2	2.5	3.6	-1.9	1.8	0.9	1.4	1.6
Diabetes (self-reported)	2.2	3.4	5.2	1.8	-2.3	-1.6	1.2	-2.1
Wheeze or whistling in the chest in last year	2.2	4.0	8.3	0.4	2.9	1.5	1.7	2.6
Medication: Ibuprofen	2.2	2.6	5.9	0.0	2.4	1.8	0.4	1.9
Irritability	2.2	3.6	6.8	0.7	-2.6	-1.9	-1.0	-2.6
Ever had prostate specific antigen (PSA) test	2.2	2.5	4.4	-1.0	1.7	2.1	0.3	2.0
Fasting Glucose	2.1	2.5	11.6	3.4	-0.2	0.5	0.6	-0.1
Smoking status: Previous	2.1	3.2	9.8	-0.4	-1.4	-3.1	1.2	-1.6
Lung FEV1/FVC ratio	2.0	10.4	18.7	2.0	-4.3	-2.3	-3.3	-3.6
Pack years adult smoking proportion	2.0	3.0	6.6	0.8	1.7	0.5	2.6	2.1
Qualifications: None of the above	2.0	4.2	8.4	-2.3	2.3	0.7	2.9	1.1
Allergy	2.0	4.7	10.6	1.6	-2.8	-1.1	-1.2	-3.3
Shortness of breath walking on level ground	2.0	2.4	4.6	-0.5	1.6	1.7	1.3	2.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.9	3.0	6.4	1.0	-2.5	-1.5	0.6	-2.1
Suffer from ‘nerves’	1.9	3.0	6.9	0.0	-2.6	-1.2	-0.5	-2.6
Primary Biliary Cirrhosis	1.8	2.6	6.7	-1.3	1.0	-0.1	2.6	1.8
Medication: Lansoprazole	1.8	2.0	6.1	1.4	0.9	-0.1	2.5	1.2
Number of children fathered	1.8	2.0	8.5	-0.2	0.1	-0.4	2.9	1.1
Supplements: Zinc	1.7	1.9	2.8	-1.2	-1.4	-1.4	-1.1	-1.7
Serious illness, injury or assault to yourself	1.7	2.1	4.0	-0.9	1.8	0.2	2.0	1.5
Standing height	1.7	17.0	25.9	2.3	-4.8	-4.1	-3.7	-5.1
Peak expiratory flow (PEF)	1.7	3.9	7.3	2.7	-2.0	-1.6	-1.4	-1.8
Birth weight	1.7	3.7	7.4	1.0	-2.4	-2.1	-0.5	-2.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.7	2.0	3.2	-1.5	1.5	0.6	1.8	1.3
Prospective memory result	1.6	1.9	3.2	0.5	1.7	0.7	1.8	1.7
Pulse wave Arterial Stiffness index	1.6	1.9	4.0	1.2	-2.0	-0.6	-0.6	-1.8
Past tobacco smoking	1.5	2.7	8.1	0.0	1.2	2.9	-1.1	1.6
Hair/balding pattern: Pattern 2	1.5	1.9	6.8	0.2	-1.1	0.9	-2.6	-0.7
Happiness	1.5	1.8	3.6	-0.2	1.8	1.3	0.5	1.9
Hearing aid user	1.5	1.7	4.3	0.9	0.1	2.1	-1.5	1.0
Average weekly spirits intake	1.4	1.7	4.4	2.1	0.3	-0.7	1.7	0.8
Diabetes (father)	1.4	1.7	5.3	2.3	1.4	-0.2	0.4	1.0
Taking other prescription medications	1.4	2.1	3.6	-0.3	0.9	1.7	1.7	1.9
Had menopause	1.4	1.8	2.8	-1.7	-1.1	-1.2	-1.4	-1.2
Pulse rate	1.4	2.4	9.7	-0.0	0.9	0.5	3.1	1.2
Ever highly irritable/argumentative for 2 days	1.4	1.6	3.3	0.5	1.2	1.6	0.9	1.8
Pack years of smoking	1.4	2.1	5.4	0.2	1.3	0.4	2.3	1.8
Serious illness, injury or assault of a close relative in last 2 years	1.3	1.5	2.5	-0.2	-1.5	-1.1	-1.1	-1.6
Asthma	1.3	2.5	5.9	-0.0	2.4	0.7	1.7	1.9
Commuting to job workplace: Public transport	1.3	1.6	3.0	0.8	-1.7	-0.8	-1.4	-1.3
Unable to work because of sickness or disability	1.3	1.6	5.9	1.0	-0.8	0.6	-2.4	-0.5
Schizophrenia vs Biploar Disorder	1.2	1.6	4.5	-1.1	1.0	-0.5	2.1	1.1
Bipolar Disorder (2011)	1.2	1.2	3.1	1.5	-0.5	0.1	-1.8	-0.5
Schizophrenia (2014)	1.2	2.7	5.3	0.5	1.6	1.0	2.3	2.1
Pain all over the body in last month	1.2	1.3	2.5	-0.7	1.2	1.3	-0.6	1.6
Pulse wave peak to peak time	1.2	1.4	3.0	-1.3	1.7	0.3	0.5	1.5
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	3.3	-1.1	1.8	0.6	1.4	1.7
Asthma (self-reported)	1.2	2.4	5.6	0.3	2.4	0.6	1.4	1.9
Commuting to job workplace: Cycle	1.2	1.4	4.1	1.4	1.0	0.2	-2.0	0.5
Crohns Disease (2012)	1.1	1.8	4.2	0.9	-2.0	-1.2	0.8	-1.4
Medication: Co-codamol	1.1	1.3	2.8	-1.7	0.9	0.5	1.2	1.1
Number of live births	1.1	1.6	4.9	-1.3	1.1	0.1	2.2	0.4
Emphysema/chronic bronchitis	1.1	1.2	3.0	0.1	0.9	0.5	1.4	1.7
Supplements: Vitamin C	1.1	1.4	3.8	-0.8	-1.1	-0.4	-2.0	-0.9
Knee pain experienced in last month	1.1	1.7	4.8	-0.1	1.1	-0.7	2.2	1.4
Commuting to job workplace: Walk	1.1	1.2	4.0	0.0	0.5	1.3	-2.0	0.5
Medication: Atorvastatin	1.1	1.4	2.5	-0.2	-1.6	-0.4	-1.3	-1.6
Myopia	1.1	1.6	5.6	-2.4	-1.1	0.3	-0.3	-0.9
Bipolar Disorder (2018)	1.0	1.6	5.8	0.9	-0.7	0.7	-2.4	-0.5
Age at First Birth	1.0	1.5	3.6	-0.4	1.2	1.9	-1.3	0.7
Smoking Status	1.0	2.4	6.6	0.6	0.7	-2.1	2.6	-0.2
Type 2 Diabetes (T2D) (2018)	1.0	1.9	4.5	2.1	-1.2	-0.8	1.0	-1.4
Hearing difficulty/problems: Yes	1.0	1.5	2.8	1.3	1.0	1.2	0.5	1.7
Average weekly fortified wine intake	1.0	1.2	3.8	-1.2	0.2	0.8	-1.9	0.3
Hearing difficulty/problems with background noise	1.0	1.6	2.4	1.3	0.8	1.6	1.3	1.2
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	5.2	2.3	0.4	1.6	0.0	0.8
Medication: Amlodipine	1.0	1.4	3.7	-0.7	-1.9	-1.0	-0.3	-1.4
Number of full sisters	1.0	1.2	2.1	0.8	1.3	-0.2	1.4	1.1
Age at last live birth	1.0	1.5	3.5	0.8	-1.9	-0.5	-0.2	-1.7
Loneliness, isolation	1.0	1.3	2.7	1.2	-0.5	0.6	-1.6	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.3	0.9	1.5	1.0	-0.6	1.2
Ever taken oral contraceptive pill	1.0	1.1	2.1	-0.1	-1.3	-1.5	-0.9	-0.8
Deep venous thrombosis (DVT) (self-reported)	1.0	1.3	3.6	-1.0	0.6	1.2	-1.9	0.4
Schizophrenia (2018)	0.9	1.9	3.9	0.6	1.3	0.3	2.0	1.8
LDL Cholesterol	0.9	1.5	4.3	2.1	-1.3	-0.5	0.5	-1.0
Rheumatoid Arthritis	0.9	1.2	2.3	-1.1	-1.5	-1.1	0.5	-1.1
Sensitivity / hurt feelings	0.9	1.5	3.2	-1.8	0.0	-0.6	1.7	-1.1
Townsend deprivation index at recruitment	0.9	1.3	3.2	0.3	1.8	0.9	0.7	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.1	3.2	0.6	-1.3	-1.8	-1.5	-1.7
Trunk fat-free mass	0.9	5.3	7.0	2.2	-2.0	-2.0	-2.6	-2.6
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	4.5	2.0	-2.1	-1.1	-1.6	-1.9
Lung cancer (father)	0.9	1.1	3.1	1.8	-1.1	0.5	0.4	-0.9
Trunk predicted mass	0.9	5.4	7.3	2.2	-1.9	-2.0	-2.6	-2.7
Blood clot in the leg (DVT)	0.9	1.2	3.9	-0.7	0.4	1.1	-2.0	0.3
Pulse rate, automated reading	0.9	2.7	7.4	-0.3	-1.8	-1.3	2.7	-1.2
Illnesses of father: Heart disease	0.9	1.3	3.0	1.2	-1.1	-0.4	-1.7	-0.6
Whole body fat-free mass	0.9	5.0	6.7	1.9	-2.0	-2.0	-2.6	-2.6
Leg fat-free mass (right)	0.9	4.7	7.1	1.3	-2.1	-1.9	-2.6	-2.7
Medication: Gliclazide	0.9	1.0	2.1	1.2	-1.1	-0.4	0.1	-1.4
Whole body water mass	0.9	4.9	7.2	1.8	-2.0	-1.9	-2.7	-2.6
Leg predicted mass (right)	0.9	4.9	7.5	1.4	-2.2	-1.8	-2.6	-2.7
Tinnitus: Yes, now most or all of the time	0.9	1.0	1.8	-0.7	1.4	0.7	0.9	1.2
Eye problems/disorders: Glaucoma	0.9	1.0	2.1	0.5	1.2	0.2	1.1	1.5
Alcohol drinker status: Never	0.9	1.1	2.3	-0.6	1.3	0.5	0.8	1.5
Pain experienced in last month	0.9	1.5	3.2	0.5	-1.1	-0.7	-1.5	-1.8
Major Depression (MDD)	0.8	1.0	2.3	0.5	-1.0	-1.5	0.5	-1.2
Prostate Cancer	0.8	1.1	5.6	0.1	0.1	0.2	-2.4	0.2
Height	0.8	14.7	23.7	2.0	-4.9	-2.3	-4.2	-4.7
Other serious medical condition/disability diagnosed by doctor	0.8	1.0	1.9	-0.4	-1.4	-0.1	-1.3	-1.1
Hand grip strength (right)	0.8	2.2	4.4	1.0	-1.1	-1.0	-2.1	-1.8
Hayfever, allergic rhinitis or eczema	0.8	1.8	5.2	-0.9	1.5	0.7	0.6	2.3
Sitting height	0.8	5.6	13.5	1.2	-2.3	-1.5	-3.7	-2.4
High blood pressure (mother)	0.8	1.2	2.6	-0.2	-0.8	-1.0	-1.6	-1.2
Nervous feelings	0.8	1.4	5.8	-2.4	0.1	0.9	0.8	-0.2
Mouth/teeth dental problems	0.8	1.2	2.4	1.0	-1.5	-0.1	-1.5	-0.2
High blood pressure (siblings)	0.8	1.1	2.6	1.6	-0.8	1.1	-1.1	-0.2
Arm fat-free mass (right)	0.8	4.2	7.5	1.9	-1.5	-1.8	-2.7	-2.2
Arm predicted mass (right)	0.8	4.2	7.7	1.7	-1.5	-1.7	-2.8	-2.3
Medication: Aspirin	0.8	1.1	3.1	0.1	0.9	1.8	0.3	1.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.1	0.6	0.9	0.0	1.8	0.8
Ever smoked	0.8	1.4	3.5	0.9	-0.9	-1.9	-0.0	-1.4
Basal metabolic rate	0.8	4.3	5.8	2.0	-1.9	-1.6	-2.3	-2.4
Crohns Disease (2017)	0.7	1.6	4.6	0.6	-2.1	-1.4	1.0	-0.6
Type 2 Diabetes (T2D) (2012)	0.7	0.9	2.3	1.5	-1.0	-0.8	-0.3	-0.5
Allergy or Eczema	0.7	2.0	4.2	-2.0	0.9	0.4	0.7	2.1
Chronotype (morning person)	0.7	1.7	6.8	-2.6	-0.5	-1.1	-0.1	0.6
Hand grip strength (left)	0.7	1.7	2.9	1.7	-0.9	-0.5	-1.5	-1.5
Number of treatments/medications taken	0.7	1.2	2.5	-0.3	1.0	0.9	1.6	1.3
Leg fat-free mass (left)	0.7	3.7	5.8	1.2	-1.9	-1.7	-2.2	-2.4
Leg predicted mass (left)	0.7	3.7	5.8	1.3	-1.9	-1.7	-2.2	-2.4
Hair/balding pattern: Pattern 3	0.7	1.0	3.7	0.5	-0.1	-1.9	0.7	-0.7
Illnesses of mother	0.7	0.9	2.4	-0.5	0.2	-0.4	1.5	1.3
Hair/balding pattern: Pattern 4	0.7	1.6	3.6	0.2	-1.9	-1.6	-0.4	-1.4
Pulse wave reflection index	0.7	0.8	2.2	1.3	-0.2	-0.1	-1.5	-0.4
Loud music exposure frequency	0.7	0.8	2.6	-0.5	0.8	0.5	0.2	1.6
Comparative body size at age 10	0.7	1.9	7.2	-0.9	-0.3	1.2	-2.7	0.2
Chest pain or discomfort	0.7	1.0	1.9	-0.4	1.2	1.1	0.3	1.4
Average weekly red wine intake	0.7	1.0	1.8	-0.2	-1.4	-1.1	-0.7	-1.1
Mood swings	0.7	1.3	2.2	1.5	-0.0	-1.1	1.5	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.0	1.3	0.2	-0.1	1.4	0.4
Arm fat-free mass (left)	0.7	3.3	4.5	1.9	-1.5	-1.5	-2.1	-2.1
Fractured/broken bones in last 5 years	0.7	0.8	2.4	0.3	-0.8	0.2	-1.6	-1.0
Arm predicted mass (left)	0.7	3.5	5.6	1.9	-1.3	-1.5	-2.4	-2.1
Alzheimer’s Disease (including proxy)	0.6	0.9	1.7	-0.0	1.0	1.3	0.6	1.2
Triglycerides	0.6	0.9	3.3	1.8	0.1	0.2	1.1	0.2
Frequency of depressed mood in last 2 weeks	0.6	0.9	3.5	1.9	0.2	0.8	0.5	-0.0
Current tobacco smoking	0.6	0.9	1.8	0.9	1.3	-0.1	1.3	0.5
Supplements: Glucosamine	0.6	0.8	2.6	-0.9	0.1	-1.6	0.8	-0.3
Medication: Atenolol	0.6	0.7	1.9	-0.9	-0.6	0.6	-1.4	-0.4
Number of incorrect matches in round	0.6	1.0	2.5	-1.1	0.7	1.6	0.6	0.7
Had other major operations	0.6	0.8	2.9	0.3	-1.0	0.2	-1.7	-0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.8	3.3	0.2	-1.7	-0.4	-1.8	-1.6
Mouth/teeth dental problems: Bleeding gums	0.6	0.8	1.8	-0.2	1.3	1.1	0.5	1.0
Leg fat percentage (right)	0.6	2.1	4.5	1.0	1.2	2.1	1.3	1.4
Heart disease (mother)	0.6	0.7	1.4	0.7	1.2	0.9	0.2	0.8
Long-standing illness, disability or infirmity	0.6	0.9	2.8	0.0	-1.7	-0.4	0.2	-1.1
Friendships satisfaction	0.6	0.7	2.0	1.0	-0.7	0.1	-1.4	0.0
Guilty feelings	0.6	0.9	2.1	0.6	-1.3	-0.4	-0.5	-1.5
Financial situation satisfaction	0.6	0.7	2.9	1.7	0.3	0.6	0.3	0.4
Leg fat percentage (left)	0.6	2.2	4.9	0.9	1.3	2.2	1.1	1.6
Basal cell carcinoma (self-reported)	0.6	0.8	1.7	-0.4	-0.7	-1.3	0.3	-1.1
Heart attack/myocardial infarction (self-reported)	0.6	0.8	1.3	-1.1	0.6	1.1	0.8	0.7
Heart disease (siblings)	0.6	0.7	1.6	-0.4	-0.9	-0.9	-0.6	-1.3
Irritable Bowel Disease (IBD)	0.5	1.2	2.3	-0.9	-1.5	-1.2	1.0	0.3
Ulcerative Colitis (UC)	0.5	1.0	3.2	-1.8	-0.4	-0.8	0.3	0.8
Ovarian Cancer	0.5	0.7	2.5	1.6	-0.8	0.5	-0.1	-0.5
HDL Cholesterol	0.5	0.8	1.9	-1.4	-0.3	1.0	-1.0	-0.3
Relative age of first facial hair	0.5	0.9	2.3	1.5	0.3	1.3	0.1	0.7
Ever used hormone-replacement therapy (HRT)	0.5	0.6	1.7	-1.3	0.2	-0.3	-1.0	-0.1
Severe depression (siblings)	0.5	0.5	2.0	-0.2	0.2	1.4	0.0	0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	1.3	-1.1	0.4	0.3	0.4	1.1
Multivitamins +/- minerals	0.5	0.7	1.3	0.4	-0.3	-0.8	-1.2	-1.0
Medication: Levothyroxine sodium	0.5	0.9	2.5	-0.9	-0.9	-0.1	-0.4	-1.6
Chronic bronchitis/emphysema (father)	0.5	0.6	2.2	0.0	0.9	0.3	1.5	-0.1
Neuroticism score	0.5	1.1	2.6	0.7	-1.4	-0.5	0.2	-1.6
Time employed in main current job	0.5	0.6	1.7	-0.4	0.7	0.1	1.3	0.6
Exposure to tobacco smoke at home	0.5	0.6	0.8	0.9	-0.9	0.2	-0.7	-0.9
Qualifications: O levels/GCSEs or equivalent	0.5	0.8	2.0	0.2	-1.2	0.4	-1.4	-0.4
Comparative height size at age 10	0.5	2.7	10.6	1.1	-0.3	-0.5	-3.2	-1.1
Family relationship satisfaction	0.5	0.6	1.2	0.9	0.5	1.1	0.0	0.7
Eye problems/disorders: Cataract	0.5	0.6	1.7	-1.3	0.4	-0.5	-1.0	-0.0
Illnesses of father: None of the above (group 1)	0.5	0.6	0.8	-0.8	-0.9	-0.7	-0.7	-0.8
Average weekly champagne plus white wine intake	0.5	0.7	1.0	-1.0	0.9	0.5	-1.0	0.7
Mother’s age at death	0.5	0.6	2.8	-0.3	-0.3	0.3	-1.7	0.1
Medication: Bendroflumethiazide	0.5	0.7	1.6	0.5	-1.2	0.2	-1.3	-0.2
Medication: Lisinopril	0.5	0.6	2.0	-0.6	0.2	-0.3	1.4	0.7
Worry (Nagel 2018)	0.4	0.8	3.2	-1.8	-0.7	0.4	0.4	-0.2
Lupus	0.4	0.6	1.7	1.3	0.6	0.7	0.4	0.3
Ulcerative Colitis	0.4	0.6	1.6	0.2	-1.3	-1.2	0.2	-0.1
Blood Eosinophil Count	0.4	3.2	8.6	-0.4	2.9	1.1	0.9	2.2
BMI	0.4	2.3	4.6	1.2	1.8	2.1	0.4	1.4
Waist Hip Ratio (WHR)	0.4	1.8	6.0	2.5	-0.7	-0.5	1.5	-0.3
Vitamin and mineral supplements	0.4	0.6	1.2	-0.6	0.3	0.7	1.1	0.8
Impedance of leg (right)	0.4	1.9	5.6	0.6	0.7	0.8	2.4	1.6
Heel bone mineral density (BMD) T-score, automated (left)	0.4	1.0	2.5	-0.7	-0.8	-0.9	-1.6	-0.8
Impedance of leg (left)	0.4	2.1	4.0	0.9	1.0	1.2	2.0	1.9
Financial difficulties in last 2 years	0.4	0.5	1.5	-0.6	1.2	0.3	0.7	0.5
Heart attack	0.4	0.5	1.0	-0.8	0.4	1.0	0.6	0.4
Hayfever/allergic rhinitis (self-reported)	0.4	0.5	1.4	-0.3	1.2	-0.3	0.4	0.9
Medication: Ramipril	0.4	0.5	1.0	-0.5	-0.7	0.8	-1.0	-0.3
Weight	0.4	2.1	2.9	1.7	-1.5	-0.5	-1.5	-1.7
Alcohol intake versus 10 years previously	0.4	0.5	1.2	1.0	-0.7	-1.1	0.2	-0.1
Father’s age at death	0.4	0.6	2.3	-0.4	0.3	0.6	1.5	-0.0
Mouth/teeth dental problems: Dentures	0.4	0.7	1.5	-0.5	-0.0	-1.2	1.0	-1.0
Headache pain in last month	0.4	0.7	1.2	-1.1	0.8	0.8	0.3	1.1
Hypothyroidism/myxoedema (self-reported)	0.4	0.7	2.5	-0.1	-0.8	-0.7	-0.2	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.5	-0.2	1.2	0.7	0.1	0.5
Had major operations	0.4	0.4	0.9	-0.4	-0.9	-0.3	-0.2	-0.9
Leg pain on walking	0.4	0.5	0.8	-0.5	0.2	0.9	0.9	0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.2	0.7	0.3	0.7	0.4	1.1
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.1	0.7	0.3	-0.8	1.0	0.3
Ever had bowel cancer screening	0.4	0.4	1.3	-0.1	0.5	-0.2	1.2	0.6
Osteoarthritis (self-reported)	0.4	0.6	1.4	-0.5	0.4	-0.5	1.2	0.9
Smoking status: Current	0.4	0.7	1.7	0.5	1.1	-0.4	1.3	0.2
Number of self-reported non-cancer illnesses	0.4	0.6	1.2	0.2	0.9	0.0	1.1	1.1
Miserableness	0.4	0.7	2.3	1.5	-0.1	-0.1	0.3	-0.9
Medication: Paracetamol	0.4	0.6	1.5	0.2	-0.2	-1.0	1.2	-0.4
Illnesses of father: High blood pressure	0.4	0.4	1.1	1.1	-0.0	0.4	0.9	0.3
Diastolic blood pressure, automated reading	0.4	1.2	3.0	-0.9	0.9	1.7	-0.1	1.2
Medication: Omeprazole (e.g. Zanprol)	0.4	0.4	1.9	0.3	-0.3	-0.0	1.4	-0.4
Supplements: Calcium	0.4	0.4	1.3	0.2	-0.8	-0.2	-1.1	-0.3
Bipolar Disorder or Schizophrenia	0.3	0.6	1.3	1.1	0.6	0.7	0.0	1.1
Depression (Nagel 2018)	0.3	0.5	1.1	1.0	0.8	0.6	0.3	-0.4
Body Mass Index (BMI) (2010)	0.3	0.4	1.0	-0.2	0.4	-0.0	1.0	0.8
Hypothyroidism (self reported)	0.3	0.7	1.6	-0.8	0.9	0.6	1.3	0.2
Neuroticism	0.3	0.8	2.7	0.0	-1.1	0.0	-0.4	-1.6
Ever had hysterectomy (womb removed)	0.3	0.4	0.9	0.9	0.5	-0.4	0.4	0.7
Systolic blood pressure, automated reading	0.3	0.9	2.3	-1.0	-0.3	0.8	-1.5	-0.4
Angina	0.3	0.4	0.9	1.0	-0.1	0.7	0.6	0.4
Relative age voice broke	0.3	0.5	0.6	0.8	-0.5	-0.7	-0.8	-0.6
Waist circumference	0.3	1.1	3.9	2.0	-0.8	-0.0	-0.0	-0.8
Forced vital capacity (FVC)	0.3	1.2	1.6	1.1	-1.2	-1.0	-0.8	-1.2
Illnesses of siblings	0.3	0.5	1.0	-1.0	0.6	-0.4	0.9	0.3
Arm fat percentage (right)	0.3	1.0	3.5	0.7	0.3	1.9	0.8	0.5
Hip circumference	0.3	1.5	2.2	1.2	-1.2	-0.7	-1.4	-1.5
Glaucoma (self-reported)	0.3	0.4	0.9	0.0	0.5	-0.6	0.6	0.9
Exposure to tobacco smoke outside home	0.3	0.3	0.5	0.7	-0.1	-0.6	-0.7	-0.5
Number of full brothers	0.3	0.4	1.2	-0.3	-0.5	-0.1	1.1	-0.7
Age at first live birth	0.3	0.6	1.3	0.5	-0.3	1.1	-1.1	-0.5
Angina (self-reported)	0.3	0.4	1.2	1.1	-0.0	0.7	0.6	0.4
Migraine (self-reported)	0.3	0.3	0.6	-0.7	0.7	0.6	0.5	-0.0
Medication: Omeprazole	0.3	0.3	1.3	-0.1	0.0	0.6	1.1	0.0
Breast cancer (self-reported)	0.3	0.4	0.6	-0.5	0.6	0.8	-0.8	0.4
Pain type(s) experienced in last month: Hip pain	0.3	0.4	1.4	0.0	-1.2	0.3	-0.8	-0.3
Supplements: Fish oil (including cod liver oil)	0.3	0.4	0.9	0.7	0.4	-1.0	-0.7	0.2
Ever depressed for a whole week	0.3	0.3	0.9	-0.9	0.1	0.6	0.7	0.1
Cholesterol lowering medication	0.3	0.4	0.6	0.8	-0.8	0.2	0.8	-0.1
Depressed Affect (Nagel 2018)	0.2	0.4	0.9	1.0	0.5	0.6	-0.0	-0.5
Alzheimer’s Disease (in mother)	0.2	0.3	0.7	0.3	0.5	0.8	-0.5	0.2
Alzheimer’s Disease (in father)	0.2	0.2	0.8	0.1	-0.1	-0.6	0.9	0.1
Breast Cancer	0.2	0.5	1.1	-1.1	0.7	0.3	1.0	-0.2
Coronary Artery Disease (CAD)	0.2	0.2	0.6	-0.2	-0.3	-0.4	0.2	0.8
Neuroticism (2016)	0.2	0.3	0.9	-0.1	-0.1	1.0	0.4	-0.6
Blood Platelet Count	0.2	2.0	6.9	-0.1	0.4	-1.4	2.6	0.9
Blood White Count	0.2	1.4	4.4	2.1	0.8	-0.9	1.0	0.4
Heel T-Score	0.2	1.3	3.3	-0.8	-0.4	-1.5	-1.8	0.2
Fed-up feelings	0.2	0.3	1.1	1.0	-0.1	0.3	0.5	-0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.2	0.7	0.2	0.5	-0.3	0.8	-0.3
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.5	-0.3	0.7	-0.3	0.5	0.6
Stomach or abdominal pain in last month	0.2	0.2	0.7	-0.2	-0.3	0.0	0.8	-0.5
Trunk fat mass	0.2	0.7	1.8	1.4	-1.0	0.2	-0.3	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.6	0.8	-0.5	0.5	-0.4	-0.5
Medication: Simvastatin	0.2	0.2	0.5	0.6	-0.7	0.2	0.5	0.2
Impedance of arm (right)	0.2	0.8	2.8	-0.2	-1.0	-0.0	1.7	-0.1
Worrier / anxious feelings	0.2	0.3	0.5	0.6	-0.6	-0.2	0.7	-0.5
Noisy workplace	0.2	0.2	0.5	0.7	0.2	0.0	0.1	0.6
Depression (self-reported)	0.2	0.3	0.6	-0.2	0.2	-0.8	0.8	0.2
Impedance of arm (left)	0.2	0.8	1.9	-0.5	-1.4	-0.4	1.1	-0.7
Arm fat mass (right)	0.2	0.6	1.8	1.3	-0.5	0.9	-0.3	-0.6
Medication: Paracetamol	0.2	0.3	0.7	0.5	0.7	-0.2	0.8	0.4
Medication for cholesterol, blood pressure or diabetes	0.2	0.3	1.2	1.1	0.3	-0.4	0.1	-0.3
Medication: Ventolin 100micrograms inhaler	0.2	0.2	0.7	-0.4	-0.4	-0.4	0.8	0.1
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.5	0.7	0.6	0.1	0.1	0.0
Body fat percentage	0.2	0.6	1.7	0.9	-0.0	1.3	0.6	0.4
Health satisfaction	0.2	0.2	0.5	0.5	-0.6	0.0	0.1	-0.7
Medication: Blood pressure	0.2	0.4	1.8	-1.4	0.2	0.4	-0.2	0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.7	-0.3	0.8	0.3	-0.3	0.3
Leg fat mass (right)	0.2	0.9	2.2	1.5	0.4	1.4	0.1	0.4
Overall health rating	0.2	0.5	1.9	1.4	-0.0	-0.2	0.5	-0.7
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.4	0.5	-0.6	-0.5	0.0	0.3
Arm fat percentage (left)	0.2	0.7	2.8	0.6	0.2	1.7	0.6	0.2
Back pain experienced in last month	0.2	0.4	0.7	0.2	0.8	0.9	-0.3	0.6
Osteoporosis (self-reported)	0.2	0.3	0.7	0.5	-0.4	0.4	0.2	-0.8
Medication: Aspirin	0.2	0.3	1.3	0.0	0.2	1.1	0.1	0.4
Medication: Blood pressure	0.2	0.4	0.8	-0.9	-0.1	0.9	-0.7	0.3
Number of operations (self-reported)	0.2	0.3	0.7	0.5	-0.3	-0.7	0.9	0.1
Leg fat mass (left)	0.2	0.7	1.8	1.4	0.3	1.3	-0.1	0.4
Neuroticism (Nagel 2018)	0.1	0.2	0.7	-0.3	-0.2	0.4	-0.0	-0.8
Blood Red Count	0.1	1.4	3.9	0.7	-1.1	-0.8	-0.9	-2.0
Systolic Blood Pressure	0.1	0.4	0.9	-0.0	-1.0	0.2	-0.8	-0.6
Cardiovascular Disease	0.1	0.3	1.0	0.0	0.2	-0.2	1.0	0.7
Tanning	0.1	0.7	1.3	0.8	1.1	-0.9	0.7	0.8
Medication for hormone replacement therapy	0.1	0.2	0.6	-0.3	-0.8	-0.3	0.1	-0.2
Trunk fat percentage	0.1	0.4	0.8	0.8	-0.5	0.9	0.6	-0.0
High blood pressure	0.1	0.2	0.5	-0.6	-0.7	0.0	-0.3	-0.3
Body mass index (BMI)	0.1	0.6	1.9	0.7	0.6	1.4	0.1	0.5
Ever unenthusiastic/disinterested for a whole week	0.1	0.2	0.4	-0.3	0.6	-0.5	0.3	0.2
Falls in the last year	0.1	0.1	0.3	-0.5	0.1	-0.2	0.1	-0.5
Medication: Cholesterol lowering	0.1	0.2	0.8	-0.1	-0.9	-0.1	-0.5	0.1
Breastfed as a baby	0.1	0.2	0.3	-0.5	0.3	0.3	-0.3	0.6
Tense / ‘highly strung’	0.1	0.2	0.3	0.2	-0.5	0.6	0.4	0.3
Birth weight of first child	0.1	0.2	0.5	-0.5	0.5	-0.1	0.5	0.7
Gout (self-reported)	0.1	0.1	0.2	-0.3	-0.1	-0.5	0.1	0.2
Forced vital capacity (FVC), Best measure	0.1	0.5	0.9	-0.1	-0.8	-0.2	-1.0	-0.8
Worry too long after embarrassment	0.1	0.2	0.3	0.4	-0.6	0.2	0.6	-0.6
Eye problems/disorders: None of the above	0.1	0.2	0.4	0.2	-0.3	0.7	0.4	0.3
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.4	0.5	-0.1	-0.5	0.1
Neck or shoulder pain in last month	0.1	0.1	0.4	0.1	-0.7	-0.4	-0.0	-0.1
Medication: Allopurinol	0.1	0.2	0.4	-0.4	-0.2	-0.6	0.3	0.4
Whole body fat mass	0.1	0.6	2.0	1.4	-0.6	0.6	-0.3	-0.4
Alcohol intake frequency.	0.1	0.1	0.4	0.5	0.0	0.2	-0.6	-0.2
Hypertension (Self-reported)	0.1	0.2	0.4	-0.6	-0.7	0.1	-0.5	-0.1
Illnesses of siblings: Diabetes	0.1	0.1	0.2	0.3	-0.4	-0.4	-0.2	0.0
Mineral and other dietary supplements	0.1	0.2	0.3	0.5	-0.6	0.3	-0.1	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.4	-0.6	-0.1	-0.1	-0.2	0.6
Arm fat mass (left)	0.1	0.5	1.5	1.2	-0.6	0.6	-0.2	-0.7
High cholesterol (Self-reported)	0.1	0.1	0.3	0.6	-0.4	0.1	0.0	0.4
Average weekly beer plus cider intake	0.1	0.2	0.7	-0.1	-0.2	-0.3	-0.8	0.3
Risk taking	0.1	0.2	0.6	-0.8	0.4	-0.1	0.3	0.3
Vascular/heart problems diagnosed by doctor	0.1	0.2	0.5	0.3	0.7	-0.1	0.4	0.3
Alcohol drinker status: Previous	0.1	0.1	0.7	0.2	-0.1	-0.0	0.8	0.1
Impedance of whole body	0.1	0.7	2.9	-0.0	-0.6	0.1	1.7	0.3
Lung FVC	0.0	0.2	0.5	0.7	0.4	0.6	0.0	0.5
Hair Pigment	0.0	0.4	0.9	0.1	-0.7	0.9	-0.8	0.2
Medication for cholesterol	0.0	0.1	0.3	0.0	0.6	-0.1	-0.1	-0.1

Hub : Genes

NKIRAS1

Models

Trait associations