TWAS hub - RPL15

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Breast Invasive Carcinoma	0.0355	0.0208	7.3e-05	0.016	0.016	0.014	NA	0.014	0.00025	0.00021	0.00048	NA	0.00052
2	TCGA	Ovarian Serous Cystadenocarcinoma	0.1370	0.0880	1.1e-03	0.058	0.045	0.047	NA	0.053	0.00009	0.00048	0.00041	NA	0.00018

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Verbal and Numeric Reasoning (VNR)	15.3	36.7	40.9	-5.7	-6.4
Intelligence (Savage-Jansen 2018)	13.6	41.9	46.5	-6.1	-6.8
Fluid intelligence score	12.6	26.2	29.0	-4.8	-5.4
Qualifications: CSEs or equivalent	7.5	9.9	10.7	3.0	3.3
Alcohol usually taken with meals	6.5	10.6	11.6	-3.1	-3.4
Qualifications: College or University degree	5.9	18.5	19.5	-4.2	-4.4
Mean Putamen Volume	4.8	5.5	5.5	2.3	2.3
Respiratory disease	4.5	9.9	12.3	3.5	2.8
Qualifications: nursing, teaching	4.5	7.0	7.8	-2.5	-2.8
Length of working week for main job	4.1	4.5	4.7	-2.2	-2.1
Qualifications: A levels/AS levels or equivalent	4.0	8.8	10.0	-3.2	-2.8
HbA1C	3.8	4.2	4.8	1.9	2.2
Allergy	3.8	8.8	9.6	-3.1	-2.8
Diabetes (mother)	3.7	4.7	4.9	-2.2	-2.1
Seen a psychiatrist for nerves, anxiety, tension or depression	3.5	4.6	5.8	-1.8	-2.4
Pack years adult smoking proportion	3.4	5.2	6.1	2.5	2.1
Wears glasses or contact lenses	3.3	3.8	5.0	-2.2	-1.6
Age when periods started (menarche)	3.0	7.2	8.6	-2.4	-2.9
Prospective memory result	2.9	3.5	4.1	1.7	2.0
Primary Biliary Cirrhosis	2.8	4.1	5.3	2.3	1.7
Wheeze or whistling in the chest in last year	2.8	5.1	5.7	2.4	2.1
Shortness of breath walking on level ground	2.8	3.4	3.4	1.8	1.8
Suffer from ‘nerves’	2.8	4.4	5.4	-2.3	-1.8
Forced expiratory volume in 1-second (FEV1), predicted	2.8	5.7	6.0	-2.5	-2.3
Medication: Metformin	2.7	3.9	4.6	-1.8	-2.1
Pulse wave Arterial Stiffness index	2.7	3.1	3.7	-1.9	-1.6
Medication for pain relief, constipation, heartburn	2.7	4.6	5.8	-2.4	-1.8
Irritability	2.7	4.6	4.9	-2.1	-2.2
Supplements: Zinc	2.6	2.8	2.9	-1.7	-1.6
Hair/balding pattern: Pattern 2	2.6	3.3	4.8	-2.2	-1.4
Pulse rate	2.6	4.3	5.9	1.7	2.4
Serious illness, injury or assault of a close relative in last 2 years	2.6	3.0	3.7	-1.5	-1.9
Medication: Ibuprofen (e.g. Nurofen)	2.6	3.4	3.9	2.0	1.7
Birth weight	2.6	5.7	6.8	-2.2	-2.6
Medication: Ibuprofen	2.4	2.8	3.4	1.8	1.5
Pack years of smoking	2.4	3.5	4.3	2.1	1.6
Schizophrenia vs Biploar Disorder	2.3	3.1	3.7	1.9	1.6
Lung FEV1/FVC ratio	2.3	11.9	12.5	-3.5	-3.4
Happiness	2.3	2.8	3.5	1.9	1.4
Mouth/teeth dental problems: Mouth ulcers	2.3	3.6	3.8	1.8	2.0
Fractured/broken bones in last 5 years	2.3	2.9	3.1	-1.7	-1.8
Schizophrenia (2018)	2.2	4.6	5.1	2.0	2.3
Ever had prostate specific antigen (PSA) test	2.2	2.5	3.1	1.4	1.7
Maternal smoking around birth	2.1	3.0	3.8	1.9	1.5
Hayfever, allergic rhinitis or eczema	2.1	4.5	4.6	2.1	2.1
Standing height	2.1	20.7	23.6	-4.9	-4.2
Loneliness, isolation	2.1	2.8	3.3	-1.8	-1.5
Emphysema/chronic bronchitis	2.0	2.3	2.7	1.6	1.4
Medication: Seretide 50 evohaler	2.0	2.3	3.4	1.1	1.9
Age at last live birth	2.0	2.8	3.3	-1.5	-1.8
Eye problems/disorders: Glaucoma	2.0	2.4	2.9	1.7	1.4
Schizophrenia (2014)	1.9	4.2	5.1	2.2	1.8
Taking other prescription medications	1.9	2.9	3.6	1.9	1.5
High blood pressure (mother)	1.9	2.6	3.1	-1.5	-1.8
Asthma (self-reported)	1.9	3.7	4.5	2.1	1.7
Serious illness, injury or assault to yourself	1.8	2.2	2.4	1.5	1.4
Asthma	1.8	3.6	4.4	2.1	1.7
Illnesses of mother	1.8	2.3	3.3	1.8	1.1
Pulse wave peak to peak time	1.8	2.2	2.8	1.7	1.2
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.8	2.1	2.7	1.6	1.3
Medication: Atorvastatin	1.8	2.3	3.1	-1.8	-1.2
Bipolar Disorder (2018)	1.7	2.7	3.1	-1.5	-1.8
Medication: Lansoprazole	1.7	1.9	2.9	1.7	0.9
Seen doctor (GP) for nerves, anxiety, tension or depression	1.7	2.6	2.9	-1.5	-1.7
Number of children fathered	1.7	2.0	3.4	1.8	0.8
Other serious medical condition/disability diagnosed by doctor	1.6	2.1	2.5	-1.3	-1.6
Had menopause	1.6	2.0	2.1	-1.4	-1.4
Diabetes (self-reported)	1.6	2.4	3.0	-1.3	-1.7
Loud music exposure frequency	1.6	1.7	2.4	1.6	1.0
Knee pain experienced in last month	1.6	2.4	4.0	2.0	0.9
Leg predicted mass (right)	1.6	8.3	9.6	-3.1	-2.6
Commuting to job workplace: Public transport	1.6	1.9	2.2	-1.3	-1.5
Number of full sisters	1.5	1.8	2.1	1.5	1.2
Leg fat-free mass (right)	1.5	8.0	9.2	-3.0	-2.6
Diabetes diagnosed by doctor	1.5	2.5	3.0	-1.4	-1.7
Medication: Gliclazide	1.5	1.7	1.9	-1.2	-1.4
Tinnitus: Yes, now most or all of the time	1.5	1.8	2.6	1.0	1.6
Reaction Time	1.4	2.7	3.6	1.4	1.9
Allergy or Eczema	1.4	3.6	3.9	2.0	1.8
Hearing difficulty/problems: Yes	1.4	2.1	2.3	1.5	1.4
Diabetes (father)	1.4	1.8	2.1	1.4	1.2
Townsend deprivation index at recruitment	1.4	2.0	2.1	1.5	1.3
Arm predicted mass (right)	1.4	7.1	7.1	-2.6	-2.7
Supplements: Vitamin C	1.4	1.7	2.5	-1.6	-0.9
Whole body water mass	1.4	8.0	8.7	-2.9	-2.7
Height	1.3	25.4	29.5	-5.4	-4.6
Number of treatments/medications taken	1.3	2.3	2.4	1.5	1.5
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	1.7	1.2	1.3
Pain all over the body in last month	1.3	1.4	1.8	1.0	1.3
Trunk fat-free mass	1.3	7.2	7.8	-2.8	-2.6
Trunk predicted mass	1.3	7.6	8.3	-2.9	-2.6
Pulse wave reflection index	1.3	1.6	2.2	-1.0	-1.5
Arm fat-free mass (right)	1.3	6.5	6.5	-2.5	-2.5
Whole body fat-free mass	1.3	7.4	8.0	-2.8	-2.6
Alcohol drinker status: Never	1.3	1.5	1.8	1.4	1.1
Unable to work because of sickness or disability	1.3	1.6	2.7	-1.7	-0.7
Pain experienced in last month	1.3	2.2	3.8	-1.9	-0.8
Leg fat-free mass (left)	1.2	6.3	7.5	-2.7	-2.2
Hand grip strength (right)	1.2	3.2	4.8	-2.2	-1.3
Leg predicted mass (left)	1.2	6.2	7.5	-2.7	-2.2
Hearing difficulty/problems with background noise	1.2	1.9	3.0	0.9	1.7
Lung cancer (father)	1.2	1.4	1.5	-1.2	-1.2
Medication: Amlodipine	1.2	1.6	2.4	-1.0	-1.5
Basal metabolic rate	1.2	6.9	7.8	-2.8	-2.4
Heart disease (siblings)	1.2	1.5	1.9	-1.1	-1.4
Arm predicted mass (left)	1.2	6.3	6.4	-2.5	-2.5
Sitting height	1.1	7.9	8.5	-2.9	-2.7
Ever highly irritable/argumentative for 2 days	1.1	1.3	1.9	1.4	0.9
Long-standing illness, disability or infirmity	1.1	1.6	1.8	-1.2	-1.4
Arm fat-free mass (left)	1.1	5.7	5.9	-2.4	-2.3
Average weekly spirits intake	1.0	1.2	1.9	1.4	0.7
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.2	2.3	-1.5	-1.5
Weight	1.0	4.8	5.9	-2.4	-2.0
Osteoporosis (self-reported)	1.0	1.2	1.4	-1.2	-1.0
Crohns Disease (2012)	0.9	1.4	1.7	-1.1	-1.3
Rheumatoid Arthritis	0.9	1.2	1.7	-0.9	-1.3
Hand grip strength (left)	0.9	2.3	3.5	-1.9	-1.1
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	1.5	1.2	0.9
Peak expiratory flow (PEF)	0.9	2.1	2.9	-1.1	-1.7
Mean time to correctly identify matches	0.9	1.6	2.2	1.0	1.5
Number of self-reported non-cancer illnesses	0.9	1.5	2.4	1.5	0.8
Blood Eosinophil Count	0.8	6.2	7.6	2.2	2.8
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	0.9	-0.9	-0.9
Impedance of leg (right)	0.8	3.7	3.8	1.9	1.9
Multivitamins +/- minerals	0.8	1.1	1.2	-1.0	-1.1
Medication: Levothyroxine sodium	0.8	1.4	1.8	-1.4	-1.0
Impedance of leg (left)	0.8	3.9	4.1	1.9	2.0
Had other major operations	0.8	0.9	1.2	-0.8	-1.1
Qualifications: None of the above	0.8	1.7	1.7	1.3	1.3
Neuroticism score	0.8	1.6	1.7	-1.3	-1.2
Hip circumference	0.8	3.4	4.1	-2.0	-1.7
Falls in the last year	0.8	1.0	1.1	-1.1	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	3.1	-1.4	-1.8
Glaucoma (self-reported)	0.8	0.9	1.7	1.3	0.4
Handedness (chirality/laterality): Left-handed	0.8	1.0	1.6	1.3	0.6
Guilty feelings	0.8	1.3	1.4	-1.2	-1.1
Alzheimer’s Disease (including proxy)	0.7	1.0	1.0	1.0	1.0
Bipolar Disorder (2011)	0.7	0.7	0.7	-0.9	-0.8
Current tobacco smoking	0.7	1.1	1.5	0.8	1.2
Medication: Ramipril	0.7	0.9	1.1	-0.8	-1.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	2.9	-1.4	-1.7
Exposure to tobacco smoke at home	0.7	0.8	0.9	-0.9	-0.9
Hypothyroidism/myxoedema (self-reported)	0.7	1.3	1.4	-1.2	-1.1
Medication: Lisinopril	0.7	0.9	1.0	1.0	0.9
Major Depression (MDD)	0.6	0.7	1.2	-0.5	-1.1
Ovarian Cancer	0.6	0.8	0.8	-0.9	-0.9
Age at First Birth	0.6	0.8	1.6	-0.2	1.3
Body Mass Index (BMI) (2010)	0.6	0.9	0.9	1.0	0.9
Coronary Artery Disease (CAD)	0.6	0.7	1.0	1.0	0.6
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.4	-0.1	-1.2
Neuroticism	0.6	1.5	2.0	-1.4	-1.0
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.0	1.0	0.6
Financial difficulties in last 2 years	0.6	0.8	0.9	0.8	1.0
Chest pain or discomfort	0.6	0.8	0.8	0.9	0.9
Illnesses of father: Heart disease	0.6	0.9	1.3	-1.1	-0.7
Type 2 Diabetes (T2D) (2018)	0.5	1.0	1.1	-0.9	-1.1
Ever had hysterectomy (womb removed)	0.5	0.6	0.7	0.7	0.8
Systolic blood pressure, automated reading	0.5	1.6	2.3	-1.5	-0.9
Vitamin and mineral supplements	0.5	0.7	0.8	0.9	0.8
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	0.7	0.8	0.7
Illnesses of siblings	0.5	0.7	1.0	0.6	1.0
Number of live births	0.5	0.6	1.1	1.1	0.4
High blood pressure (siblings)	0.5	0.8	0.8	-0.9	-0.9
Average weekly red wine intake	0.5	0.8	0.8	-0.9	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.5	0.6	0.8	0.6
Osteoarthritis (self-reported)	0.5	0.7	1.3	1.1	0.3
Illnesses of father: None of the above (group 1)	0.5	0.7	0.7	-0.8	-0.9
Mother’s age at death	0.5	0.6	0.9	-0.4	-1.0
Ulcerative Colitis (UC)	0.4	0.8	1.6	1.2	0.1
HDL Cholesterol	0.4	0.6	0.6	-0.8	-0.8
Blood Platelet Count	0.4	4.5	4.8	2.0	2.2
Medication: Co-codamol	0.4	0.5	0.6	0.8	0.7
Trunk fat mass	0.4	1.8	2.5	-1.6	-1.1
Waist circumference	0.4	1.3	1.7	-1.3	-1.0
Time employed in main current job	0.4	0.5	0.8	0.9	0.5
Arm fat mass (right)	0.4	1.6	2.2	-1.5	-1.0
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	0.5	0.7	0.7
Headache pain in last month	0.4	0.6	0.9	0.9	0.6
Chronic bronchitis/emphysema (mother)	0.4	0.5	1.0	0.0	1.0
Had major operations	0.4	0.5	0.5	-0.7	-0.7
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	0.7	0.6	0.8
Medication: Aspirin	0.4	0.5	0.7	0.6	0.8
Ever had bowel cancer screening	0.4	0.5	0.9	0.9	0.1
Smoking status: Current	0.4	0.7	1.0	0.6	1.0
Arm fat mass (left)	0.4	1.8	2.2	-1.5	-1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	0.7	-0.6	-0.8
Age started oral contraceptive pill	0.4	0.6	0.9	0.9	-0.5
Myopia	0.4	0.6	1.2	-1.1	0.1
Supplements: Calcium	0.4	0.5	0.6	-0.6	-0.8
Heart attack/myocardial infarction (self-reported)	0.4	0.5	0.8	0.5	0.9
Neuroticism (2016)	0.3	0.5	0.9	-0.9	-0.3
Blood Red Count	0.3	3.0	5.0	-2.2	-1.0
Smoking Status	0.3	0.6	0.7	0.8	0.7
Relative age voice broke	0.3	0.4	0.8	-0.9	-0.3
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	0.6	-0.8	-0.8
Medication: Atenolol	0.3	0.4	0.7	-0.8	-0.4
Depression (self-reported)	0.3	0.4	0.4	0.7	0.5
Hair/balding pattern: Pattern 4	0.3	0.7	0.9	-0.9	-0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.5	-0.6	-0.7
Age at first live birth	0.3	0.5	1.0	-1.0	-0.3
Health satisfaction	0.3	0.5	0.6	-0.6	-0.8
Heart disease (mother)	0.3	0.4	0.6	0.5	0.8
Whole body fat mass	0.3	1.3	1.8	-1.3	-0.9
Comparative height size at age 10	0.3	1.6	3.3	-1.8	0.0
Commuting to job workplace: Car/motor vehicle	0.3	0.4	0.4	0.7	0.6
Smoking status: Previous	0.3	0.5	0.8	-0.4	-0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.5	0.5	0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.7	1.3	1.2	0.0
Miserableness	0.3	0.6	0.7	-0.7	-0.8
Medication: Bendroflumethiazide	0.3	0.5	1.0	-1.0	-0.1
Cholesterol lowering medication	0.3	0.4	0.7	-0.2	0.8
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	-0.2	-0.8
Bipolar Disorder or Schizophrenia	0.2	0.4	0.4	0.6	0.6
Neuroticism (Nagel 2018)	0.2	0.4	0.5	-0.7	-0.5
Crohns Disease (2017)	0.2	0.4	0.7	-0.1	-0.9
Irritable Bowel Disease (IBD)	0.2	0.4	0.7	0.8	-0.2
Prostate Cancer	0.2	0.2	0.4	-0.6	-0.2
Triglycerides	0.2	0.3	0.4	0.5	0.6
Ulcerative Colitis	0.2	0.3	0.5	0.4	-0.7
Blood White Count	0.2	1.2	1.3	1.1	1.1
Cardiovascular Disease	0.2	0.7	0.7	0.8	0.8
Severe depression (siblings)	0.2	0.2	0.3	0.3	0.5
High blood pressure	0.2	0.4	0.7	-0.8	-0.4
Number of incorrect matches in round	0.2	0.3	0.4	0.5	0.7
Past tobacco smoking	0.2	0.3	0.4	0.4	0.6
Frequency of tenseness / restlessness in last 2 weeks	0.2	0.3	0.5	-0.7	-0.2
Forced vital capacity (FVC)	0.2	0.6	0.9	-0.6	-0.9
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.4	0.6	0.4
Mouth/teeth dental problems	0.2	0.3	0.3	-0.5	-0.6
Heart attack	0.2	0.2	0.4	0.2	0.7
Medication: Simvastatin	0.2	0.3	0.5	0.2	0.7
Alcohol intake versus 10 years previously	0.2	0.2	0.3	0.5	-0.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	-0.3	-0.7
Blood clot in the leg (DVT)	0.2	0.3	0.3	-0.5	-0.5
Medication: Paracetamol	0.2	0.4	0.7	0.9	0.0
Worry too long after embarrassment	0.2	0.3	0.3	-0.6	0.5
Eye problems/disorders: None of the above	0.2	0.2	0.3	0.1	0.6
Neck or shoulder pain in last month	0.2	0.3	0.4	-0.4	-0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	0.3	0.3	0.5
Pulse rate, automated reading	0.2	0.5	0.8	-0.5	-0.9
Alcohol intake frequency.	0.2	0.5	1.0	-0.2	-1.0
Overall health rating	0.2	0.4	0.5	-0.6	-0.7
Leg pain on walking	0.2	0.2	0.3	0.6	0.3
Illness, injury, bereavement, stress in last 2 years	0.2	0.2	0.3	0.3	0.6
Medication: Paracetamol	0.2	0.3	0.5	0.3	-0.7
Ever smoked	0.2	0.4	0.4	-0.6	-0.6
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.7	0.8	0.5
Depressed Affect (Nagel 2018)	0.1	0.2	0.3	-0.5	-0.4
Alzheimer’s Disease (in father)	0.1	0.1	0.1	0.3	0.1
Breast Cancer	0.1	0.2	0.4	0.1	0.6
Fasting Glucose	0.1	0.1	0.2	0.2	-0.4
LDL Cholesterol	0.1	0.2	0.2	-0.5	-0.3
Lupus	0.1	0.1	0.1	0.4	0.3
BMI	0.1	0.7	1.1	0.5	1.1
Systolic Blood Pressure	0.1	0.7	0.9	-1.0	-0.7
Hypothyroidism (self reported)	0.1	0.3	0.4	0.6	0.6
Lung FVC	0.1	0.5	0.9	1.0	0.4
Chronotype (morning person)	0.1	0.3	0.5	0.7	0.2
Tanning	0.1	1.0	1.1	0.9	1.1
Sensitivity / hurt feelings	0.1	0.1	0.2	-0.5	-0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.1	-0.4	0.1
Angina	0.1	0.1	0.1	-0.1	0.4
Trunk fat percentage	0.1	0.4	0.7	-0.8	-0.4
Average weekly fortified wine intake	0.1	0.1	0.1	-0.4	-0.1
Fed-up feelings	0.1	0.1	0.2	-0.4	-0.1
Supplements: Glucosamine	0.1	0.1	0.2	0.3	0.4
Nervous feelings	0.1	0.1	0.2	-0.3	0.4
Impedance of arm (right)	0.1	0.4	0.7	0.2	0.8
Father’s age at death	0.1	0.2	0.2	0.5	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.2	0.5	0.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.3	0.3	-0.6
Noisy workplace	0.1	0.1	0.1	0.3	0.2
Birth weight of first child	0.1	0.1	0.2	0.5	-0.1
Gout (self-reported)	0.1	0.2	0.2	0.3	-0.4
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.2	0.4	-0.3
Forced vital capacity (FVC), Best measure	0.1	0.5	0.8	-0.4	-0.9
Leg fat percentage (right)	0.1	0.3	0.4	0.5	0.6
Exposure to tobacco smoke outside home	0.1	0.1	0.2	-0.1	-0.5
Comparative body size at age 10	0.1	0.3	0.6	-0.8	-0.2
Number of full brothers	0.1	0.1	0.2	-0.5	-0.2
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.5	-0.0
Medication: Blood pressure	0.1	0.1	0.2	-0.5	-0.1
Migraine (self-reported)	0.1	0.1	0.2	0.1	-0.5
Medication: Allopurinol	0.1	0.2	0.4	0.6	0.0
Leg fat mass (right)	0.1	0.2	0.4	-0.6	-0.2
Family relationship satisfaction	0.1	0.2	0.2	0.4	0.3
Hypertension (Self-reported)	0.1	0.4	0.6	-0.8	-0.4
Arm fat percentage (left)	0.1	0.3	0.5	-0.7	-0.2
Friendships satisfaction	0.1	0.2	0.3	-0.2	-0.6
Commuting to job workplace: Walk	0.1	0.1	0.1	-0.3	-0.2
Eye problems/disorders: Cataract	0.1	0.1	0.2	-0.2	-0.5
Medication for cholesterol	0.1	0.2	0.3	0.3	-0.5
Mineral and other dietary supplements	0.1	0.1	0.2	-0.4	-0.3
Average weekly champagne plus white wine intake	0.1	0.1	0.1	0.1	0.4
Ever taken oral contraceptive pill	0.1	0.1	0.3	-0.5	-0.0
Financial situation satisfaction	0.1	0.1	0.1	0.4	0.2
High cholesterol (Self-reported)	0.1	0.2	0.3	0.3	0.6
Illnesses of father: High blood pressure	0.1	0.2	0.2	0.5	0.3
Leg fat percentage (left)	0.1	0.3	0.3	0.5	0.6
Number of operations (self-reported)	0.1	0.1	0.2	0.5	-0.1
Diastolic blood pressure, automated reading	0.1	0.2	0.5	0.1	0.7
Ever depressed for a whole week	0.1	0.1	0.2	0.4	-0.0
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.1	-0.4	-0.3
Impedance of whole body	0.1	0.7	0.9	0.7	0.9
Leg fat mass (left)	0.1	0.3	0.5	-0.7	-0.4
Depression (Nagel 2018)	0.0	0.1	0.1	-0.3	-0.2
Worry (Nagel 2018)	0.0	0.0	0.0	-0.0	-0.1
Alzheimer’s Disease (in mother)	0.0	0.0	0.0	0.1	-0.2
Heel T-Score	0.0	0.3	0.3	0.5	0.5
Waist Hip Ratio (WHR)	0.0	0.0	0.0	0.2	0.1
Hair Pigment	0.0	0.4	0.9	-0.9	0.0
Frequency of depressed mood in last 2 weeks	0.0	0.0	0.1	-0.1	0.3
Relative age of first facial hair	0.0	0.1	0.1	-0.0	0.3
Medication for hormone replacement therapy	0.0	0.1	0.1	-0.3	0.0
Frequency of unenthusiasm / disinterest in last 2 weeks	0.0	0.0	0.0	0.2	0.1
Stomach or abdominal pain in last month	0.0	0.0	0.0	-0.0	-0.0
Chronic bronchitis/emphysema (father)	0.0	0.0	0.0	-0.1	-0.1
Body mass index (BMI)	0.0	0.1	0.1	-0.3	-0.2
Arm fat percentage (right)	0.0	0.1	0.3	-0.5	0.1
Worrier / anxious feelings	0.0	0.0	0.0	0.1	0.1
Medication: Cholesterol lowering	0.0	0.0	0.0	-0.0	-0.1
Impedance of arm (left)	0.0	0.1	0.1	-0.3	0.3
Breastfed as a baby	0.0	0.1	0.1	0.1	0.3
Tense / ‘highly strung’	0.0	0.0	0.1	0.1	-0.2
Medication for cholesterol, blood pressure or diabetes	0.0	0.0	0.1	0.0	0.3
Body fat percentage	0.0	0.2	0.3	-0.6	-0.1
Mouth/teeth dental problems: Loose teeth	0.0	0.0	0.0	-0.0	-0.1
Angina (self-reported)	0.0	0.1	0.1	-0.0	0.4
Medication: Omeprazole	0.0	0.0	0.0	-0.1	-0.0
Illnesses of siblings: Diabetes	0.0	0.0	0.1	-0.1	-0.2
Mood swings	0.0	0.1	0.1	0.1	-0.4
Back pain experienced in last month	0.0	0.0	0.1	0.2	-0.2
Breast cancer (self-reported)	0.0	0.0	0.0	-0.0	-0.2
Medication: Aspirin	0.0	0.0	0.0	0.0	0.2
Hearing aid user	0.0	0.0	0.0	0.0	0.2
Medication: Blood pressure	0.0	0.1	0.1	-0.3	0.0
Supplements: Fish oil (including cod liver oil)	0.0	0.0	0.1	0.3	0.1
Average weekly beer plus cider intake	0.0	0.0	0.1	0.2	0.2
Risk taking	0.0	0.0	0.1	0.1	0.3
Commuting to job workplace: Cycle	0.0	0.0	0.0	0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.0	0.0	0.0	-0.2	-0.2
Alcohol drinker status: Previous	0.0	0.1	0.1	0.3	-0.2

Hub : Genes

RPL15

Models

Trait associations