Best TWAS P=1.94e-11 · Best GWAS P=7.08e-15 conditioned to 7.13e-05
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PPA2 | 0.08 | 0.03 | bslmm | 429 | 0.04 | 2.2e-05 | -5.3 | -6.1 | 9.4e-10 | 0.61 | 0.13 | 0.82 | FALSE |
| 2 | GTEx | Brain Cortex | PPA2 | 0.14 | 0.09 | lasso | 9 | 0.09 | 1.6e-03 | -6.4 | -6.7 | 1.9e-11 | 0.83 | 0.08 | 0.44 | TRUE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | PPA2 | 0.29 | 0.15 | lasso | 5 | 0.14 | 8.8e-06 | -7.0 | -6.2 | 6.1e-10 | 0.84 | 0.14 | 0.76 | FALSE |
| 4 | GTEx | Heart Atrial Appendage | PPA2 | 0.15 | 0.05 | lasso | 7 | 0.06 | 7.4e-04 | -6.6 | -5.8 | 7.1e-09 | 0.67 | 0.26 | 0.32 | FALSE |
| 5 | The Cancer Genome Atlas | Thyroid Carcinoma | PPA2 | 0.04 | 0.02 | blup | 84 | 0.04 | 6.1e-05 | -6.8 | -5.9 | 4.3e-09 | 0.73 | 0.01 | 0.96 | FALSE |