TWAS
hub
About
Usage
Models
Genes
Traits
[Hub]/) :
Traits
:
Verbal and Numeric Reasoning (VNR)
:
←
→
chr4:105,598,022-107,092,169
Best TWAS P=1.94e-11 · Best GWAS P=7.08e-15 conditioned to 7.13e-05
105.6M
105.8M
106M
106.2M
106.4M
106.6M
106.8M
107M
0
5
10
15
physical position
-log10 P
Marginal
▼
Associated models
#
Study
Tissue
Gene
h2
eQTL R2
model
# weights
model R2
model R2 P
eQTL GWAS Z
TWAS Z
TWAS P
Top SNP corr
PP3
PP4
joint
2
GTEx
Brain Cortex
PPA2
0.14
0.09
lasso
9
0.09
1.6e-03
-6.4
-6.7
1.9e-11
0.83
0.08
0.44
TRUE
3
GTEx
Esophagus Gastroesophageal Junction
PPA2
0.29
0.15
lasso
5
0.14
8.8e-06
-7.0
-6.2
6.1e-10
0.84
0.14
0.76
FALSE
1
CommonMind
Brain Pre-frontal Cortex
PPA2
0.08
0.03
bslmm
429
0.04
2.2e-05
-5.3
-6.1
9.4e-10
0.61
0.13
0.82
FALSE
5
The Cancer Genome Atlas
Thyroid Carcinoma
PPA2
0.04
0.02
blup
84
0.04
6.1e-05
-6.8
-5.9
4.3e-09
0.73
0.01
0.96
FALSE
4
GTEx
Heart Atrial Appendage
PPA2
0.15
0.05
lasso
7
0.06
7.4e-04
-6.6
-5.8
7.1e-09
0.67
0.26
0.32
FALSE