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chr5:138,860,604-140,745,333

Best TWAS P=3.34e-11 · Best GWAS P=1.13e-10 conditioned to 0.272

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
9	GTEx	Brain Nucleus accumbens basal ganglia	PFDN1	0.16	0.01	lasso	5	0.03	5.6e-02	5.6	6.6	3.3e-11	-0.81	0.04	0.63	TRUE
25	GTEx	Skin Sun Exposed Lower leg	WDR55	0.04	0.01	enet	10	0.01	2.8e-02	-4.2	-5.3	1.2e-07	0.34	0.37	0.24	TRUE
37	The Cancer Genome Atlas	Lung Adenocarcinoma	PFDN1	0.03	0.02	blup	47	0.02	5.5e-03	-6.4	6.6	4.7e-11	-0.92	0.01	0.91	FALSE
16	GTEx	Esophagus Gastroesophageal Junction	PFDN1	0.24	0.09	enet	20	0.12	3.3e-05	-5.4	6.4	1.3e-10	-0.49	0.32	0.27	FALSE
35	The Cancer Genome Atlas	Brain Lower Grade Glioma	PFDN1	0.05	0.01	blup	47	0.01	1.9e-02	-5.7	6.2	5.1e-10	-0.66	0.03	0.45	FALSE
4	GTEx	Artery Aorta	PFDN1	0.20	0.15	lasso	2	0.17	1.3e-09	-5.4	6.2	6.8e-10	-0.57	0.66	0.33	FALSE
31	ROSMAP	Brain Pre-frontal Cortex	ZMAT2	0.03	0.02	bslmm	185	0.02	6.5e-04	-4.2	-6.1	8.5e-10	0.52	0.72	0.12	FALSE
39	The Cancer Genome Atlas	Prostate Adenocarcinoma	HBEGF	0.03	0.03	lasso	3	0.02	2.2e-03	-6.1	6.1	9.5e-10	-0.79	0.00	0.96	FALSE
5	GTEx	Artery Coronary	PFDN1	0.15	0.06	enet	11	0.04	1.9e-02	-5.4	6.1	1.1e-09	-0.74	0.05	0.74	FALSE
11	GTEx	Breast Mammary Tissue	PFDN1	0.17	0.20	lasso	5	0.19	4.1e-10	-5.4	5.9	2.9e-09	-0.71	0.51	0.49	FALSE
12	GTEx	Breast Mammary Tissue (Male)	PFDN1	0.24	0.04	lasso	9	0.09	4.0e-03	-3.4	5.9	4.5e-09	-0.54	0.06	0.73	FALSE
20	GTEx	Heart Left Ventricle	PFDN1	0.31	0.33	enet	17	0.33	4.2e-18	-5.4	5.8	9.0e-09	-0.58	0.66	0.34	FALSE
15	GTEx	Colon Sigmoid	PFDN1	0.33	0.32	lasso	12	0.28	2.1e-10	-5.4	5.6	1.7e-08	-0.57	0.42	0.58	FALSE
23	GTEx	Skin Not Sun Exposed Suprapubic	PFDN1	0.10	0.10	lasso	3	0.10	5.3e-06	-5.5	5.6	2.1e-08	-0.55	0.55	0.36	FALSE
38	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	PFDN1	0.04	0.02	lasso	3	0.03	2.0e-04	-5.4	5.6	2.4e-08	-0.64	0.31	0.32	FALSE
7	GTEx	Artery Tibial	CYSTM1	0.19	0.17	lasso	9	0.14	2.8e-11	-5.4	5.6	2.5e-08	-0.58	0.64	0.36	FALSE
34	The Cancer Genome Atlas	Brain Lower Grade Glioma	C5orf32	0.03	0.04	lasso	2	0.04	3.1e-05	-5.4	5.5	3.5e-08	-0.58	0.53	0.38	FALSE
13	GTEx	Cells EBV-transformed lymphocytes	PFDN1	0.20	0.02	lasso	3	0.03	4.4e-02	-5.4	5.5	3.6e-08	-0.62	0.11	0.29	FALSE
2	GTEx	Adipose Subcutaneous	PFDN1	0.20	0.19	lasso	4	0.18	6.3e-15	-5.5	5.5	3.7e-08	-0.57	0.64	0.36	FALSE
17	GTEx	Esophagus Muscularis	PFDN1	0.25	0.26	lasso	4	0.27	1.3e-16	-5.5	5.5	4.0e-08	-0.56	0.63	0.37	FALSE
21	GTEx	Muscle Skeletal	PFDN1	0.45	0.56	enet	22	0.56	6.5e-66	-5.4	5.5	4.0e-08	-0.56	0.68	0.32	FALSE
30	ROSMAP	Brain Pre-frontal Cortex	PFDN1	0.05	0.05	lasso	1	0.04	2.1e-06	-5.5	5.5	4.2e-08	-0.55	0.62	0.37	FALSE
26	GTEx	Spleen	PFDN1	0.26	0.02	lasso	5	0.12	6.0e-04	5.6	5.5	4.3e-08	-0.69	0.03	0.56	FALSE
8	GTEx	Brain Cortex	CYSTM1	0.20	0.01	lasso	10	0.00	3.1e-01	-5.5	5.5	4.4e-08	-0.55	0.06	0.08	FALSE
22	GTEx	Nerve Tibial	CYSTM1	0.20	0.20	lasso	3	0.20	5.5e-14	-5.4	5.5	4.5e-08	-0.57	0.64	0.36	FALSE
33	The Cancer Genome Atlas	Breast Invasive Carcinoma	PFDN1	0.02	0.01	enet	4	0.02	7.8e-05	-5.4	5.5	4.5e-08	-0.55	0.47	0.34	FALSE
18	GTEx	Esophagus Muscularis	CYSTM1	0.09	0.08	lasso	1	0.08	1.2e-05	-5.5	5.5	4.9e-08	-0.56	0.40	0.48	FALSE
10	GTEx	Brain Nucleus accumbens basal ganglia	CYSTM1	0.22	0.08	lasso	8	0.06	8.5e-03	-5.5	5.5	5.0e-08	-0.53	0.06	0.42	FALSE
40	The Cancer Genome Atlas	Prostate Adenocarcinoma	PFDN1	0.06	0.07	lasso	5	0.06	3.2e-07	-5.4	5.5	5.1e-08	-0.58	0.58	0.42	FALSE
6	GTEx	Artery Tibial	PFDN1	0.19	0.19	enet	12	0.22	9.8e-17	-5.4	5.4	5.2e-08	-0.57	0.66	0.34	FALSE
14	GTEx	Cells Transformed fibroblasts	PFDN1	0.31	0.39	enet	16	0.42	1.5e-33	-5.4	5.4	5.3e-08	-0.57	0.66	0.34	FALSE
28	GTEx	Thyroid	PFDN1	0.10	0.07	lasso	4	0.05	1.5e-04	-5.4	5.4	5.9e-08	-0.57	0.64	0.35	FALSE
36	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	PFDN1	0.07	0.05	lasso	2	0.05	2.0e-03	-5.4	5.4	6.0e-08	-0.57	0.18	0.20	FALSE
19	GTEx	Heart Atrial Appendage	PFDN1	0.12	0.14	lasso	6	0.12	4.3e-06	-5.4	5.4	6.3e-08	-0.57	0.56	0.41	FALSE
32	YFS	Blood	HBEGF	0.02	0.02	lasso	3	0.02	9.8e-07	5.6	5.3	1.1e-07	-0.82	0.25	0.74	FALSE
1	CommonMind	Brain Pre-frontal Cortex	NDUFA2	0.02	0.01	bslmm	343	0.01	7.8e-03	-4.3	5.3	1.3e-07	-0.36	0.25	0.04	FALSE
27	GTEx	Testis	PFDN1	0.15	0.00	lasso	8	0.00	4.9e-01	-5.4	5.2	1.9e-07	-0.57	0.07	0.08	FALSE
3	GTEx	Adipose Visceral Omentum	PFDN1	0.13	0.10	lasso	9	0.08	3.9e-05	-5.4	5.2	2.1e-07	-0.51	0.64	0.33	FALSE
29	GTEx	Thyroid	CYSTM1	0.07	0.05	lasso	5	0.03	3.2e-03	-5.5	5.2	2.2e-07	-0.50	0.55	0.32	FALSE
24	GTEx	Skin Sun Exposed Lower leg	PFDN1	0.16	0.12	enet	12	0.11	3.9e-09	-5.4	5.1	3.1e-07	-0.42	0.64	0.36	FALSE