TWAS hub - CYSTM1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adrenal Gland	0.1984	0.0778	6.7e-03	0.071	NA	0.048	NA	0.050	1.6e-03	NA	8.3e-03	NA	7.0e-03
2	GTEx	Artery Tibial	0.1940	0.0465	1.8e-11	0.167	NA	0.132	NA	0.143	4.3e-13	NA	1.8e-10	NA	2.8e-11
3	GTEx	Brain Caudate basal ganglia	0.2220	0.0800	1.6e-03	0.148	NA	0.035	NA	0.115	5.1e-05	NA	3.5e-02	NA	3.4e-04
4	GTEx	Brain Cortex	0.1990	0.0840	4.8e-03	0.007	NA	-0.006	NA	0.000	2.0e-01	NA	4.9e-01	NA	3.1e-01
5	GTEx	Brain Nucleus accumbens basal ganglia	0.2200	0.0820	2.4e-03	0.077	NA	0.052	NA	0.064	4.3e-03	NA	1.6e-02	NA	8.5e-03
6	GTEx	Cells Transformed fibroblasts	0.1160	0.0470	5.1e-04	0.026	NA	0.045	NA	0.045	4.5e-03	NA	2.6e-04	NA	2.4e-04
7	GTEx	Colon Transverse	0.1010	0.0430	4.4e-03	0.038	NA	0.012	NA	0.024	6.3e-03	NA	8.0e-02	NA	2.5e-02
8	GTEx	Esophagus Muscularis	0.0870	0.0340	1.8e-03	0.080	NA	0.023	NA	0.081	1.4e-05	NA	1.5e-02	NA	1.2e-05
9	GTEx	Nerve Tibial	0.1964	0.0470	1.2e-09	0.199	NA	0.196	NA	0.197	4.0e-14	NA	6.7e-14	NA	5.5e-14
10	GTEx	Thyroid	0.0710	0.0280	7.8e-04	0.047	NA	0.018	NA	0.028	1.6e-04	NA	1.5e-02	NA	3.2e-03
11	METSIM	Adipose	0.0462	0.0196	8.0e-04	0.011	0.022	0.012	0.024	0.005	7.0e-03	2.6e-04	6.1e-03	1.4e-04	4.7e-02
12	ROSMAP	Brain Pre-frontal Cortex	0.2057	0.0382	0.0e+00	0.253	0.243	0.252	0.263	0.253	2.7e-32	7.1e-31	3.8e-32	1.0e-33	2.3e-32

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Verbal and Numeric Reasoning (VNR)	9.7	23.2	31.1	-0.4	5.6	5.0	5.5	5.5	3.4	3.6	5.5	5.5	5.2	5.0	5.1
Intelligence (Savage-Jansen 2018)	8.7	26.7	37.0	-0.3	6.1	5.3	5.9	5.7	3.8	4.1	5.6	5.8	5.4	5.5	5.6
Fluid intelligence score	8.2	17.0	21.8	1.2	4.7	4.3	4.6	3.7	3.7	3.5	4.6	4.6	4.5	4.4	4.5
Mean time to correctly identify matches	7.5	14.3	25.1	-1.5	4.5	4.2	4.3	5.0	2.0	2.7	4.3	4.6	4.0	1.8	4.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	7.4	15.7	18.7	2.1	4.3	4.3	4.3	3.5	3.7	4.1	4.3	4.2	4.2	3.7	4.2
Worry too long after embarrassment	7.1	11.8	17.3	-1.5	4.1	4.0	4.2	3.1	1.8	3.5	4.0	4.1	3.8	1.9	3.7
Ever unenthusiastic/disinterested for a whole week	7.0	8.5	11.9	0.3	3.3	3.2	3.2	3.5	2.3	2.5	3.2	3.1	3.1	2.9	3.1
Reaction Time	6.4	12.2	20.9	-1.1	4.1	4.0	4.1	4.6	1.9	2.5	4.0	4.2	3.8	2.2	3.6
Schizophrenia (2018)	6.0	12.5	23.1	-4.8	-3.2	-3.1	-3.0	-2.4	-4.3	-4.1	-3.0	-2.9	-3.2	-4.2	-3.4
Schizophrenia (2014)	6.0	13.3	28.5	-5.3	-3.1	-3.1	-3.0	-2.6	-4.6	-4.2	-3.0	-3.0	-3.3	-4.1	-3.5
Medication: Ibuprofen (e.g. Nurofen)	6.0	7.6	11.0	-3.1	-2.6	-2.9	-2.7	-2.9	-3.3	-2.8	-2.6	-2.7	-2.7	-1.3	-2.9
Bipolar Disorder or Schizophrenia	5.9	14.4	21.2	-4.0	-3.7	-3.7	-3.6	-2.9	-4.2	-4.6	-3.5	-3.5	-3.6	-3.8	-3.9
Medication: Ibuprofen	5.8	6.9	9.5	-2.8	-2.6	-2.7	-2.5	-2.6	-3.1	-2.7	-2.4	-2.6	-2.5	-2.0	-2.8
LDL Cholesterol	5.7	9.0	12.8	2.0	3.2	3.2	3.2	3.6	3.1	2.9	3.2	3.3	3.2	1.4	3.2
Medication: Paracetamol	5.5	9.1	12.4	-0.3	-3.5	-3.3	-3.3	-2.8	-2.3	-2.8	-3.5	-3.5	-3.3	-2.8	-3.3
Medication for pain relief, constipation, heartburn	5.5	9.3	11.3	2.4	3.2	3.1	3.1	2.4	3.2	3.4	3.1	3.3	3.2	2.7	3.3
Alzheimer’s Disease (in mother)	5.3	6.2	9.4	3.0	2.2	2.2	2.2	2.8	3.1	2.8	2.3	2.4	2.4	1.5	2.6
Type 2 Diabetes (T2D) (2012)	5.3	6.1	7.7	1.4	2.4	2.6	2.7	2.6	2.7	2.2	2.8	2.5	2.8	2.3	2.4
Qualifications: College or University degree	4.9	15.5	20.7	-0.2	4.5	4.0	4.5	3.9	2.9	2.8	4.5	4.5	4.3	4.3	4.3
Commuting to job workplace: Public transport	4.8	5.8	7.4	1.2	2.4	2.6	2.6	2.2	2.3	2.2	2.7	2.6	2.7	2.3	2.7
Qualifications: CSEs or equivalent	4.2	5.5	7.7	-0.4	-2.7	-2.4	-2.7	-2.5	-2.1	-1.7	-2.7	-2.8	-2.6	-1.9	-2.6
Serious illness, injury or assault to yourself	3.9	4.8	6.2	-1.8	-2.3	-2.4	-2.3	-1.3	-2.3	-2.5	-2.3	-2.3	-2.4	-1.3	-2.4
Headache pain in last month	3.9	6.6	9.3	-1.6	-2.8	-2.9	-2.7	-2.7	-2.5	-3.0	-2.6	-2.8	-2.6	-1.6	-2.8
Number of operations (self-reported)	3.6	5.3	7.2	-2.4	-2.4	-2.4	-2.4	-1.4	-2.6	-2.7	-2.4	-2.5	-2.5	-0.3	-2.5
Bipolar Disorder (2011)	3.4	3.2	5.2	-0.6	-2.1	-2.3	-2.1	-1.5	-1.3	-2.0	-1.9	-2.0	-1.9	-0.9	-2.1
Qualifications: A levels/AS levels or equivalent	3.4	7.4	9.8	1.3	3.0	2.8	2.9	2.1	2.6	2.3	3.1	3.0	3.0	3.1	2.9
Smoking status: Previous	3.4	5.1	6.8	1.1	2.4	2.6	2.5	2.2	2.0	2.0	2.4	2.4	2.4	2.1	2.4
Medication: Paracetamol	3.4	5.2	8.2	0.6	-2.9	-2.5	-2.5	-1.8	-1.3	-2.1	-2.6	-2.7	-2.5	-2.3	-2.5
Ever depressed for a whole week	3.4	4.2	9.4	-0.8	2.2	2.4	2.3	3.1	1.2	0.9	2.3	2.2	2.2	1.6	2.0
Guilty feelings	3.1	4.6	6.9	-1.5	2.6	2.5	2.6	2.0	0.9	2.0	2.4	2.6	2.2	1.4	2.3
Migraine (self-reported)	3.0	3.8	5.0	-0.6	-2.2	-1.9	-2.0	-1.9	-1.8	-1.7	-2.1	-2.2	-2.0	-1.9	-2.2
Friendships satisfaction	2.9	3.6	7.4	-0.9	2.1	2.0	2.0	2.7	1.0	0.8	2.1	2.0	2.0	2.0	2.0
Hand grip strength (left)	2.8	7.4	10.4	-1.1	-2.9	-2.8	-3.0	-3.2	-2.6	-2.2	-2.9	-3.0	-2.9	-2.3	-2.9
Coronary Artery Disease (CAD)	2.7	3.2	4.5	-2.0	-1.8	-1.8	-1.7	-1.7	-2.0	-2.1	-1.8	-1.9	-1.8	-1.1	-1.8
Neuroticism (2016)	2.7	3.9	7.6	1.0	2.4	1.9	2.0	1.4	1.8	2.8	2.0	2.3	2.0	1.2	2.3
Diverticular disease/diverticulitis (self-reported)	2.7	3.2	7.1	-2.7	-1.4	-1.3	-1.5	-1.7	-2.4	-1.8	-1.6	-1.6	-1.7	-1.3	-1.8
Ovarian Cancer	2.6	3.5	5.7	-2.3	-1.7	-1.9	-1.9	-0.9	-2.3	-2.4	-1.8	-1.8	-1.9	-0.7	-2.0
Past tobacco smoking	2.5	4.7	6.9	-0.3	-2.5	-2.6	-2.5	-2.0	-1.5	-1.8	-2.4	-2.4	-2.4	-2.0	-2.3
Qualifications: None of the above	2.5	5.3	7.4	-0.3	-2.4	-2.7	-2.7	-2.4	-1.9	-1.3	-2.7	-2.5	-2.6	-2.5	-2.4
Medication: Simvastatin	2.5	3.6	6.1	2.1	1.5	2.3	2.0	1.6	2.5	2.0	1.8	1.8	1.9	-0.9	1.9
Number of children fathered	2.5	2.8	3.7	-1.2	-1.7	-1.6	-1.8	-1.2	-1.8	-1.9	-1.9	-1.9	-1.9	-0.7	-1.9
Pain experienced in last month	2.5	4.2	5.9	2.1	2.1	1.9	2.0	1.3	2.4	2.3	2.0	2.1	2.1	1.7	2.3
Length of working week for main job	2.4	2.6	4.2	-0.0	2.0	1.9	1.7	1.2	1.1	1.2	1.8	1.9	1.7	1.9	1.8
Loud music exposure frequency	2.4	2.6	4.1	1.2	1.9	1.4	1.6	1.1	1.7	1.5	1.5	1.7	1.6	2.0	1.8
Ever had stillbirth, spontaneous miscarriage or termination	2.4	2.5	3.7	1.9	1.5	1.5	1.6	1.6	1.8	1.4	1.4	1.4	1.5	1.8	1.6
Lung FVC	2.3	11.8	16.0	1.1	4.0	4.0	3.8	3.6	2.7	3.9	3.6	3.8	3.5	2.2	3.8
Reason for reducing amount of alcohol drunk: Health precaution	2.3	2.7	4.9	1.6	1.6	1.5	1.6	1.6	1.8	2.2	1.6	1.6	1.7	1.3	1.7
Chest pain or discomfort	2.3	3.3	6.4	1.0	1.9	1.4	1.7	2.5	1.7	2.1	1.7	1.8	1.7	2.1	1.9
Prostate Cancer	2.2	3.0	5.2	-1.0	-1.8	-1.9	-2.0	-2.3	-1.7	-1.9	-1.8	-1.7	-1.8	-0.6	-1.9
Diabetes (father)	2.1	2.6	3.7	-0.1	-1.9	-1.8	-1.8	-0.9	-1.3	-1.1	-1.9	-1.9	-1.8	-1.8	-1.8
Had other major operations	2.1	2.5	3.9	-0.1	-1.8	-1.7	-1.9	-1.3	-1.3	-1.7	-1.9	-2.0	-1.9	-0.2	-1.7
Commuting to job workplace: Car/motor vehicle	2.1	2.4	4.7	-2.2	-1.2	-1.2	-1.5	-0.9	-2.1	-1.6	-1.6	-1.4	-1.7	-1.2	-1.5
Bipolar Disorder (2018)	2.0	3.2	5.3	-0.4	-1.9	-2.1	-2.0	-1.7	-1.4	-2.3	-1.9	-2.0	-1.9	-0.9	-2.0
Serious illness, injury or assault of a close relative in last 2 years	2.0	2.3	4.1	0.3	1.6	2.0	1.8	1.7	1.3	1.0	1.6	1.5	1.6	1.7	1.5
Pulse wave reflection index	2.0	2.5	3.6	1.6	1.7	1.6	1.6	1.0	1.8	1.9	1.5	1.5	1.6	1.5	1.7
Had major operations	2.0	2.3	5.6	-2.4	-1.5	-1.5	-1.2	-0.0	-1.8	-2.0	-1.3	-1.4	-1.4	-1.0	-1.5
Neuroticism	1.9	4.5	9.0	-2.4	2.3	2.2	2.4	3.0	0.3	1.8	2.2	2.3	1.9	1.4	2.0
Birth weight	1.9	4.2	6.1	2.4	1.9	1.7	1.8	1.7	2.4	2.4	1.9	1.8	1.9	2.5	2.0
Seen a psychiatrist for nerves, anxiety, tension or depression	1.9	2.5	4.7	-0.6	1.8	1.9	1.9	2.2	0.9	1.0	1.8	1.7	1.6	1.0	1.5
Qualifications: NVQ or HND or HNC or equivalent	1.9	2.3	5.6	-0.1	-1.9	-1.0	-1.6	-1.3	-1.1	-1.4	-1.6	-1.7	-1.5	-2.4	-1.5
Mother’s age at death	1.9	2.4	3.2	0.6	1.7	1.4	1.6	1.6	1.6	1.8	1.6	1.7	1.6	1.2	1.7
High cholesterol (Self-reported)	1.9	3.4	5.0	1.1	1.9	2.2	2.2	1.7	1.9	1.4	2.1	2.0	2.0	1.2	2.0
Neuroticism score	1.8	3.7	5.1	-2.0	2.2	2.2	2.3	2.2	0.5	2.1	2.0	2.2	1.8	0.7	2.0
Myopia	1.8	2.6	4.2	1.1	1.5	1.4	1.8	1.2	1.8	1.7	1.8	1.6	1.8	2.1	1.6
Alzheimer’s Disease (including proxy)	1.7	2.5	17.5	4.2	0.2	0.3	0.0	0.4	2.4	2.2	0.2	0.4	0.5	-0.4	0.8
Irritable Bowel Disease (IBD)	1.7	4.1	5.2	1.4	2.2	2.2	2.2	1.7	2.3	1.4	2.2	2.2	2.2	2.1	2.1
Ulcerative Colitis (UC)	1.7	3.2	5.4	0.5	1.8	2.0	2.0	2.3	1.6	1.0	2.1	1.9	2.0	1.5	1.7
Vitamin and mineral supplements	1.7	2.2	4.7	-1.5	-1.4	-1.6	-1.6	-1.2	-1.6	-2.2	-1.4	-1.5	-1.5	-0.7	-1.6
Hand grip strength (right)	1.7	4.7	8.2	-0.6	-2.3	-2.4	-2.5	-2.9	-1.9	-1.8	-2.3	-2.4	-2.3	-1.2	-2.4
Family relationship satisfaction	1.7	2.1	5.2	-1.7	1.4	1.5	1.5	2.3	0.2	0.2	1.7	1.5	1.5	1.2	1.3
Financial situation satisfaction	1.7	2.1	4.6	-0.3	1.5	1.5	1.5	1.9	0.7	0.8	1.6	1.5	1.5	2.2	1.4
Alcohol drinker status: Never	1.7	2.1	7.2	-1.0	-1.3	-1.0	-1.2	-1.8	-1.2	-1.0	-1.3	-1.3	-1.3	-2.7	-1.4
Cholesterol lowering medication	1.7	2.4	3.9	1.7	1.4	1.9	1.7	1.1	2.0	1.5	1.6	1.5	1.6	0.7	1.5
Type 2 Diabetes (T2D) (2018)	1.6	3.0	4.9	2.0	1.7	1.6	1.7	1.6	2.2	1.7	1.6	1.7	1.7	1.3	1.8
Exposure to tobacco smoke at home	1.6	1.8	2.6	0.7	1.3	1.2	1.4	1.4	1.2	1.0	1.6	1.5	1.6	1.5	1.4
Tanning	1.5	18.8	26.6	-1.9	-4.6	-5.2	-4.9	-4.2	-4.1	-4.4	-4.8	-4.7	-4.8	-2.6	-4.6
Stomach or abdominal pain in last month	1.5	1.8	3.1	0.3	-1.6	-1.6	-1.8	-1.2	-0.8	-1.0	-1.7	-1.6	-1.6	-0.9	-1.3
Blood clot in the leg (DVT)	1.5	1.9	2.6	-1.2	-1.4	-1.4	-1.4	-1.6	-1.5	-1.4	-1.4	-1.4	-1.5	-0.4	-1.5
Unable to work because of sickness or disability	1.5	1.9	2.7	-1.3	-1.3	-1.4	-1.5	-1.1	-1.6	-1.4	-1.5	-1.4	-1.5	-0.5	-1.6
Ulcerative Colitis	1.4	2.0	4.4	0.4	1.4	1.5	1.6	2.1	1.3	0.8	1.6	1.5	1.6	1.2	1.4
Allergy or Eczema	1.4	3.7	5.2	0.8	1.9	2.0	1.9	2.3	1.7	2.0	2.0	1.9	2.0	2.3	1.8
Medication: Metformin	1.4	2.0	5.3	0.5	1.5	1.2	1.5	1.5	1.4	0.6	1.5	1.5	1.4	2.3	1.4
Medication: Cholesterol lowering	1.4	2.2	3.9	0.9	1.4	2.0	1.8	1.8	1.5	1.1	1.6	1.6	1.6	0.1	1.6
Health satisfaction	1.4	1.9	6.1	-2.5	-1.1	-1.1	-1.1	-0.3	-1.9	-1.8	-1.1	-1.2	-1.2	-0.1	-1.3
Mouth/teeth dental problems: Loose teeth	1.4	1.7	3.9	2.0	0.8	0.9	1.1	1.9	1.5	1.7	1.0	1.0	1.1	0.6	1.2
Diabetes diagnosed by doctor	1.4	2.2	3.3	1.5	1.5	1.4	1.5	1.4	1.8	1.4	1.4	1.5	1.4	1.4	1.6
Osteoarthritis (self-reported)	1.4	1.8	5.9	-2.4	-1.2	-0.8	-0.9	-0.7	-1.8	-1.7	-1.0	-1.2	-1.1	-0.8	-1.3
Falls in the last year	1.3	1.7	2.6	-0.2	1.6	1.4	1.5	1.1	0.9	1.3	1.4	1.6	1.3	1.3	1.6
Asthma	1.3	2.6	6.7	-0.0	1.8	1.8	1.7	1.4	1.0	1.5	1.6	1.6	1.5	2.6	1.6
Seen doctor (GP) for nerves, anxiety, tension or depression	1.3	1.9	3.3	-0.6	1.6	1.8	1.8	1.5	0.9	1.1	1.6	1.6	1.5	0.1	1.4
Qualifications: O levels/GCSEs or equivalent	1.3	2.1	3.2	0.9	1.3	1.6	1.7	0.9	1.7	0.7	1.8	1.5	1.8	1.4	1.4
Hearing aid user	1.3	1.4	3.7	-1.2	-1.2	-1.0	-1.2	-0.7	-1.1	-1.3	-1.0	-1.1	-1.1	-1.9	-1.2
Ever smoked	1.3	2.2	3.5	-0.6	1.8	1.9	1.8	1.4	0.7	1.1	1.7	1.7	1.6	1.4	1.6
Neuroticism (Nagel 2018)	1.2	2.8	5.7	-2.1	1.8	1.7	1.8	2.4	0.0	1.5	1.7	1.8	1.5	1.2	1.5
Respiratory disease	1.2	2.7	8.1	-0.8	2.0	1.5	1.6	1.7	0.6	1.1	1.5	1.7	1.3	2.9	1.6
Allergy	1.2	2.7	5.0	-0.5	-1.8	-1.8	-1.8	-1.7	-1.3	-1.6	-1.7	-1.7	-1.6	-2.2	-1.6
Time employed in main current job	1.2	1.4	4.8	-0.6	1.4	1.1	1.3	1.1	0.3	0.6	1.2	1.2	1.1	2.2	1.1
Forced expiratory volume in 1-second (FEV1), Best measure	1.2	3.7	8.7	1.4	1.9	2.0	1.9	1.2	1.8	2.3	1.9	1.7	1.9	3.0	1.8
Tense / ‘highly strung’	1.2	2.0	5.3	-0.9	1.3	1.6	1.5	2.3	0.5	1.5	1.6	1.4	1.4	0.4	1.3
Shortness of breath walking on level ground	1.2	1.4	6.5	-0.7	1.1	0.6	1.1	1.7	0.1	0.3	1.1	1.0	1.0	2.5	0.8
Age started oral contraceptive pill	1.2	1.5	2.2	-0.4	-1.4	-1.5	-1.4	-0.7	-1.0	-1.2	-1.4	-1.5	-1.4	-0.9	-1.2
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	3.0	-0.6	-1.4	-1.4	-1.3	-1.7	-1.2	-1.2	-1.4	-1.4	-1.4	-0.4	-1.4
BMI	1.1	6.5	10.6	-2.0	3.2	3.2	3.1	1.6	0.7	0.8	2.9	2.9	2.6	3.2	2.4
Medication: Co-codamol	1.1	1.2	3.0	-1.7	-0.9	-1.2	-0.9	-0.8	-1.4	-0.9	-0.9	-0.9	-1.0	-1.4	-1.0
Maternal smoking around birth	1.1	1.6	4.5	0.2	-1.3	-1.1	-1.3	-2.1	-1.1	-0.9	-1.3	-1.3	-1.3	-1.2	-1.3
Heel bone mineral density (BMD) T-score, automated (left)	1.1	2.4	5.1	-0.1	1.6	2.3	1.9	1.6	1.4	0.9	1.8	1.7	1.8	0.9	1.5
Hayfever, allergic rhinitis or eczema	1.1	2.5	3.5	1.2	1.6	1.3	1.5	1.7	1.7	1.9	1.5	1.5	1.5	1.9	1.6
High blood pressure (mother)	1.1	1.5	3.5	-1.0	-1.2	-1.0	-1.1	-1.9	-1.1	-1.3	-1.0	-1.2	-1.1	-1.2	-1.3
Exposure to tobacco smoke outside home	1.1	1.5	2.3	0.9	1.2	1.5	1.3	1.1	1.3	0.9	1.4	1.3	1.4	0.5	1.4
Asthma (self-reported)	1.1	2.2	6.8	-0.2	1.7	1.5	1.5	1.4	0.8	1.3	1.4	1.5	1.4	2.6	1.5
Eye problems/disorders: Glaucoma	1.1	1.3	4.7	-2.2	-0.7	-0.8	-0.8	0.1	-1.9	-1.3	-0.7	-0.7	-0.9	-1.1	-0.9
Major Depression (MDD)	1.0	1.2	1.9	-1.2	1.3	1.2	1.2	0.8	0.6	0.5	1.4	1.3	1.2	1.1	1.1
Blood Platelet Count	1.0	11.1	20.1	-2.2	-3.4	-2.7	-3.4	-3.9	-3.5	-2.9	-3.3	-3.2	-3.3	-4.5	-3.2
Medication: Levothyroxine sodium	1.0	1.8	3.7	-0.1	1.3	1.9	1.6	1.4	0.8	1.5	1.5	1.4	1.4	-0.8	1.2
Heel bone mineral density (BMD) T-score, automated (right)	1.0	2.3	3.8	0.9	1.5	2.0	1.8	1.5	1.7	1.1	1.7	1.6	1.7	1.0	1.5
Diabetes (self-reported)	1.0	1.5	2.1	0.9	1.3	1.3	1.3	1.4	1.3	1.0	1.2	1.3	1.2	1.0	1.3
Medication: Ventolin 100micrograms inhaler	1.0	1.3	1.9	0.8	1.1	1.4	1.3	1.2	1.1	1.1	1.2	1.2	1.1	-0.1	1.3
Number of full brothers	1.0	1.3	8.1	-2.8	-0.3	-0.2	-0.4	-0.1	-1.7	-1.5	-0.5	-0.5	-0.7	-0.8	-0.7
Eye problems/disorders: None of the above	1.0	1.2	3.6	1.9	0.7	0.8	0.9	0.4	1.7	1.2	1.1	0.9	1.2	0.4	0.9
Heart disease (mother)	1.0	1.2	2.9	0.1	1.2	0.9	1.1	1.3	0.7	0.7	1.2	1.2	1.1	1.7	1.1
Risk taking	1.0	1.5	10.3	-3.2	0.0	-0.4	-0.2	-1.0	-1.6	-1.4	-0.2	-0.2	-0.5	1.0	-0.6
Commuting to job workplace: Cycle	1.0	1.2	3.8	1.4	1.1	0.4	0.7	0.1	1.3	1.2	0.9	0.9	1.0	2.0	1.0
Impedance of whole body	1.0	5.1	8.9	1.5	-3.0	-2.8	-2.8	-1.8	-1.0	-0.8	-2.6	-2.8	-2.3	-2.1	-2.3
Blood White Count	0.9	6.5	11.2	-3.3	-2.0	-2.1	-2.4	-2.0	-3.3	-3.3	-2.4	-2.2	-2.6	-1.2	-2.7
Systolic Blood Pressure	0.9	4.7	11.6	0.4	-2.7	-1.8	-2.4	-2.1	-1.1	-1.6	-2.3	-2.3	-2.1	-3.4	-2.4
Taking other prescription medications	0.9	1.5	5.8	-2.4	1.2	1.4	1.3	1.6	-0.3	-0.2	1.1	1.1	0.9	0.4	0.8
Medication: Atenolol	0.9	1.1	2.3	-0.0	-1.4	-1.0	-1.1	-0.8	-0.6	-1.5	-1.1	-1.3	-1.1	-0.7	-1.2
Body mass index (BMI)	0.9	3.9	6.9	-1.2	2.5	2.6	2.5	0.9	0.8	0.7	2.2	2.3	2.0	2.3	2.0
Hair/balding pattern: Pattern 2	0.9	1.1	2.9	-1.1	1.1	1.3	1.3	1.7	0.3	0.4	1.1	1.1	1.0	0.1	1.0
Financial difficulties in last 2 years	0.9	1.2	3.6	-0.2	1.2	1.3	1.2	1.1	0.5	0.6	1.2	1.2	1.1	1.9	1.1
Medication: Ramipril	0.9	1.2	1.7	0.9	1.0	0.9	1.0	1.3	1.3	0.8	1.2	1.1	1.2	1.0	1.1
Father’s age at death	0.9	1.2	3.2	1.2	0.9	0.6	0.8	1.8	1.5	1.2	0.9	0.9	1.0	0.8	1.1
Forced vital capacity (FVC), Best measure	0.9	3.3	8.3	0.6	1.9	1.8	1.9	1.5	1.4	2.1	1.9	1.7	1.8	2.9	1.6
Comparative body size at age 10	0.9	2.4	3.8	0.7	1.7	1.9	1.9	1.4	1.3	0.8	1.7	1.6	1.7	1.5	1.5
Pulse wave peak to peak time	0.9	1.1	2.2	-1.5	-1.0	-1.1	-1.0	0.2	-1.4	-1.2	-0.9	-1.0	-1.0	-0.3	-1.1
Neck or shoulder pain in last month	0.9	1.3	1.9	-0.9	-1.4	-1.3	-1.1	-1.2	-1.2	-0.9	-1.1	-1.4	-1.1	0.0	-1.4
Breast Cancer	0.8	2.0	4.2	1.3	1.2	0.9	1.3	1.7	1.5	1.3	1.4	1.3	1.4	2.1	1.4
Current tobacco smoking	0.8	1.3	3.0	-1.3	-0.9	-1.0	-1.1	-1.7	-1.4	-1.1	-1.0	-1.0	-1.1	-0.5	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.5	-1.6	-0.8	-1.0	-0.9	-0.3	-1.5	-0.8	-0.9	-0.9	-1.0	-0.8	-1.0
Bilateral oophorectomy (both ovaries removed)	0.8	0.9	1.3	-0.6	-0.9	-0.8	-1.0	-0.9	-1.0	-1.1	-1.1	-1.1	-1.1	0.2	-1.1
Multivitamins +/- minerals	0.8	1.0	3.1	1.8	0.6	1.0	0.8	0.1	1.1	1.7	0.6	0.7	0.7	0.6	0.9
Waist circumference	0.8	2.8	6.9	-0.3	2.1	2.0	2.1	0.6	1.0	0.8	1.8	1.9	1.7	2.6	1.7
Hearing difficulty/problems with background noise	0.8	1.3	3.1	1.6	0.9	0.8	0.9	1.8	1.4	1.0	0.9	0.9	1.0	0.7	1.0
Had menopause	0.8	1.0	1.7	-0.0	1.1	1.2	1.3	1.3	0.6	0.5	1.2	1.2	1.1	0.7	1.0
Pulse rate	0.8	1.4	6.9	0.8	-1.3	-0.9	-1.2	-2.6	-0.1	-0.3	-1.0	-1.1	-0.9	-1.3	-0.9
Pulse wave Arterial Stiffness index	0.8	1.0	1.6	1.3	1.0	1.1	1.0	-0.1	1.2	1.1	0.9	1.0	1.0	0.5	1.0
Hair/balding pattern: Pattern 4	0.8	1.8	4.3	0.6	-1.6	-2.1	-1.8	-1.0	-0.5	-1.2	-1.6	-1.5	-1.5	0.0	-1.4
Pulse rate, automated reading	0.8	2.5	7.3	1.2	-1.9	-1.1	-1.7	-2.7	-0.5	-1.0	-1.6	-1.6	-1.4	-1.8	-1.4
Ever had bowel cancer screening	0.8	0.9	2.7	-0.4	0.9	1.1	1.2	1.6	0.6	0.8	1.1	1.0	1.0	0.0	0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	8.3	0.8	0.6	-0.3	0.4	0.4	0.6	0.5	0.3	0.3	0.3	2.9	0.4
Wears glasses or contact lenses	0.8	0.9	3.3	1.6	0.7	0.5	0.6	0.7	1.1	0.8	0.5	0.5	0.6	1.8	0.8
Irritability	0.8	1.3	4.9	-2.2	0.9	1.2	1.1	1.7	-0.4	0.2	1.2	1.0	0.9	0.3	0.8
Alcohol drinker status: Previous	0.8	0.9	1.5	0.2	0.9	0.9	1.2	1.1	0.8	0.9	1.1	1.0	1.1	0.5	1.0
Chronotype (morning person)	0.7	1.5	4.0	2.0	-1.2	-1.4	-1.5	-1.4	0.1	0.1	-1.4	-1.4	-1.2	-0.3	-1.1
Severe depression (siblings)	0.7	0.8	2.0	-1.4	-0.8	-0.6	-0.8	0.4	-1.0	-1.3	-0.6	-0.7	-0.7	-1.2	-0.9
Supplements: Glucosamine	0.7	0.9	4.2	-0.5	-1.0	-0.6	-0.7	-1.4	-0.7	-0.6	-0.7	-0.7	-0.7	-2.1	-0.8
Noisy workplace	0.7	0.9	3.4	1.8	-0.9	-1.0	-1.0	-1.2	0.4	-0.5	-0.9	-1.0	-0.8	0.0	-0.8
Lung cancer (father)	0.7	0.8	3.6	-1.9	-0.6	-0.8	-0.5	-0.2	-1.3	-1.2	-0.6	-0.5	-0.7	-0.7	-0.8
Birth weight of first child	0.7	1.2	9.1	3.0	-0.3	-0.4	-0.3	-0.5	1.4	1.6	-0.3	-0.3	-0.1	-0.1	0.0
Peak expiratory flow (PEF)	0.7	1.6	13.0	3.6	-0.4	0.2	-0.3	-1.3	1.7	1.2	-0.3	-0.4	-0.0	0.0	0.2
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.8	-1.2	-0.7	-0.8	-0.8	-1.0	-1.3	-0.9	-0.8	-0.8	-0.9	0.7	-1.0
Medication: Seretide 50 evohaler	0.7	0.8	3.1	-1.3	1.0	0.6	0.8	1.1	-0.0	-0.2	0.6	0.7	0.5	1.8	0.6
Alcohol intake frequency.	0.7	1.6	5.1	-1.6	-1.1	-0.8	-0.9	-1.0	-1.4	-1.1	-1.0	-1.0	-1.1	-2.2	-1.0
Knee pain experienced in last month	0.7	1.1	2.0	-1.3	-1.0	-1.0	-0.9	0.4	-1.4	-1.4	-0.9	-1.0	-1.0	-0.6	-1.2
Arm fat percentage (left)	0.7	2.6	5.2	-0.6	1.9	2.3	2.1	0.6	0.9	0.8	1.9	1.8	1.7	1.8	1.7
Illnesses of father: None of the above (group 1)	0.7	0.9	1.5	-0.9	-0.7	-1.2	-1.1	-1.2	-0.9	-0.9	-0.9	-0.8	-1.0	0.5	-0.9
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	1.8	1.0	0.6	0.9	0.8	1.3	1.1	1.1	0.8	0.7	0.8	-0.1	0.8
Alzheimer’s Disease (in father)	0.6	0.7	3.4	1.8	-0.5	-0.6	-0.7	-0.6	0.8	1.1	-0.7	-0.6	-0.5	-0.4	-0.2
Crohns Disease (2017)	0.6	1.2	2.2	1.4	1.1	1.2	1.1	0.0	1.5	1.0	0.9	1.0	1.0	1.3	1.1
Diabetes (mother)	0.6	0.8	1.5	0.2	0.9	1.0	1.0	1.2	0.7	0.7	1.1	0.9	1.0	0.7	0.9
Tinnitus: Yes, but not now, but have in the past	0.6	0.6	4.8	0.9	0.3	-0.5	-0.2	-0.4	0.7	-0.6	-0.2	-0.0	-0.1	2.2	0.1
Nervous feelings	0.6	1.0	3.1	-0.5	0.9	1.2	1.1	1.3	0.4	1.8	0.9	1.0	0.9	-0.6	0.9
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.2	-0.7	-0.8	-1.0	-1.1	-0.7	-0.9	-0.9	-1.0	-0.9	-1.0	-0.1	-0.8
Arm fat percentage (right)	0.6	2.5	5.1	-0.7	1.9	2.3	2.1	0.3	0.9	0.8	1.8	1.8	1.7	1.7	1.6
Arm fat mass (right)	0.6	2.6	5.1	-1.4	1.9	2.2	2.0	0.3	0.4	0.4	1.8	1.8	1.6	2.2	1.4
Wheeze or whistling in the chest in last year	0.6	1.0	4.5	-2.1	1.1	0.6	0.8	0.5	-0.7	-0.2	0.9	1.0	0.6	1.4	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	3.3	1.8	0.5	0.8	0.5	0.7	1.2	0.3	0.6	0.5	0.6	0.3	0.8
Illnesses of father: Heart disease	0.6	0.9	1.6	-0.1	0.9	1.1	1.3	1.0	0.6	0.6	1.3	1.1	1.2	0.0	0.9
Breast cancer (self-reported)	0.6	0.7	1.7	-0.4	-0.9	-0.5	-0.9	-1.3	-0.8	-0.8	-0.9	-0.9	-0.9	-0.8	-0.9
Ever taken oral contraceptive pill	0.6	0.7	2.3	0.4	0.8	0.6	0.8	1.0	0.9	1.5	0.7	0.9	0.8	-0.1	0.9
Tinnitus: Yes, now most or all of the time	0.6	0.7	1.4	-0.2	-1.0	-0.9	-1.0	-1.2	-0.7	-0.3	-0.9	-0.9	-0.8	-0.9	-0.9
Fractured/broken bones in last 5 years	0.6	0.7	1.9	0.2	-1.0	-1.0	-0.9	-1.4	-0.4	-0.4	-0.9	-1.0	-0.9	-0.4	-0.8
HbA1C	0.5	0.6	1.1	-0.1	1.1	0.7	0.8	1.0	0.5	0.6	0.7	0.9	0.7	0.9	0.7
Cardiovascular Disease	0.5	1.7	3.1	0.7	1.2	1.8	1.5	1.7	1.3	0.5	1.4	1.3	1.4	1.3	1.2
Average weekly spirits intake	0.5	0.6	1.4	0.5	0.7	1.2	0.8	1.1	0.7	1.1	0.6	0.6	0.7	0.1	0.7
Forced vital capacity (FVC)	0.5	2.0	4.8	0.7	1.6	1.5	1.3	1.1	1.1	1.7	1.4	1.2	1.3	2.2	1.3
Impedance of arm (right)	0.5	2.1	3.9	2.0	-1.9	-1.8	-1.7	-1.3	0.0	0.0	-1.5	-1.7	-1.3	-1.4	-1.3
Forced expiratory volume in 1-second (FEV1)	0.5	1.5	3.7	1.5	1.2	1.3	1.0	0.5	1.3	1.6	1.0	0.9	1.0	1.9	1.0
Happiness	0.5	0.6	4.7	-2.2	-0.3	0.1	-0.1	0.3	-1.2	-1.1	-0.1	-0.3	-0.3	0.1	-0.4
Mouth/teeth dental problems: Dentures	0.5	0.9	1.9	-0.1	1.1	0.9	0.9	1.4	0.6	1.3	0.9	1.0	0.9	1.0	0.8
Impedance of arm (left)	0.5	2.4	4.3	1.8	-2.1	-1.9	-1.9	-1.2	-0.2	-0.1	-1.7	-1.9	-1.5	-1.5	-1.4
Standing height	0.5	5.3	7.7	-1.5	-2.2	-2.8	-2.6	-2.2	-2.4	-2.2	-2.4	-2.6	-2.4	1.4	-2.5
Medication: Amlodipine	0.5	0.8	1.5	-0.3	-1.0	-0.8	-0.9	-0.8	-0.9	-0.9	-0.9	-0.8	-0.8	-1.2	-1.0
Leg fat percentage (right)	0.5	1.7	4.2	-0.6	1.5	1.7	1.6	0.8	0.6	0.5	1.3	1.4	1.2	2.0	1.2
Leg pain on walking	0.5	0.7	1.6	-1.3	-0.8	-0.7	-0.7	0.5	-1.1	-0.6	-0.7	-0.9	-0.8	-0.2	-0.9
Supplements: Vitamin C	0.5	0.6	1.2	-0.1	0.7	1.1	0.9	0.7	0.5	1.0	0.7	0.8	0.7	-0.8	0.8
Forced expiratory volume in 1-second (FEV1), predicted	0.5	1.0	1.6	0.1	-1.0	-1.1	-1.3	-0.9	-0.7	-0.8	-1.1	-1.2	-1.1	0.5	-1.1
Long-standing illness, disability or infirmity	0.5	0.8	7.1	-2.7	0.2	0.1	0.2	0.8	-1.2	-0.6	0.1	0.1	-0.2	-0.2	-0.1
Medication: Aspirin	0.5	0.6	1.4	-0.8	-0.7	-0.6	-0.8	-0.3	-0.7	-1.2	-0.8	-0.7	-0.8	-1.1	-0.7
Smoking status: Current	0.5	0.8	2.2	-1.1	-0.7	-0.8	-0.8	-1.5	-1.1	-0.9	-0.8	-0.8	-0.9	-0.3	-0.9
Arm fat mass (left)	0.5	2.2	5.0	-1.4	1.8	2.0	1.8	0.4	0.3	0.2	1.6	1.6	1.4	2.2	1.3
Number of self-reported non-cancer illnesses	0.5	0.9	7.0	-2.7	0.3	0.5	0.3	1.0	-1.1	-0.9	0.2	0.3	-0.0	-0.7	-0.1
Miserableness	0.5	0.9	3.0	-0.6	1.0	0.8	1.0	1.7	0.1	1.0	0.8	0.9	0.8	1.1	0.8
Ever had prostate specific antigen (PSA) test	0.5	0.6	1.0	-0.6	1.0	0.6	0.9	0.8	0.4	0.8	0.9	0.9	0.8	0.8	0.8
Depressed Affect (Nagel 2018)	0.4	0.8	2.8	-1.4	0.8	0.5	0.8	1.7	-0.3	0.4	0.5	0.6	0.4	1.4	0.6
Schizophrenia vs Biploar Disorder	0.4	0.5	1.6	-1.3	-0.4	-0.5	-0.4	-0.8	-1.1	-0.4	-0.5	-0.4	-0.5	-1.0	-0.6
Waist Hip Ratio (WHR)	0.4	1.7	9.3	3.0	-0.7	-0.1	-0.5	-1.0	1.0	0.8	-0.6	-0.6	-0.4	-2.6	-0.1
Number of treatments/medications taken	0.4	0.6	2.5	-1.6	-0.6	0.0	-0.2	0.1	-1.0	-1.3	-0.4	-0.5	-0.5	-0.9	-0.6
Sensitivity / hurt feelings	0.4	0.8	6.1	-2.5	0.6	0.3	0.3	0.8	-0.9	0.6	0.2	0.5	0.1	-0.4	0.3
Frequency of depressed mood in last 2 weeks	0.4	0.6	4.3	-2.1	-0.0	-0.3	-0.0	0.6	-1.3	-0.4	-0.2	-0.2	-0.3	-0.0	-0.3
Impedance of leg (right)	0.4	1.9	3.3	1.2	-1.8	-1.8	-1.8	-0.7	-0.5	-0.1	-1.6	-1.7	-1.4	-1.1	-1.4
Sitting height	0.4	2.8	6.9	-1.0	-1.2	-2.0	-1.7	-1.9	-1.6	-1.3	-1.5	-1.6	-1.5	2.6	-1.5
Impedance of leg (left)	0.4	1.7	3.2	1.4	-1.8	-1.8	-1.7	-0.5	-0.3	-0.1	-1.5	-1.6	-1.3	-0.9	-1.3
Alcohol usually taken with meals	0.4	0.6	1.2	1.1	-0.6	-1.0	-0.9	-0.8	-0.0	-0.4	-1.0	-0.9	-0.9	0.4	-0.7
Heart attack	0.4	0.5	2.0	-0.9	0.5	0.8	0.8	1.4	0.1	-0.7	0.7	0.6	0.6	-0.2	0.4
Hip circumference	0.4	1.9	11.4	-2.4	1.2	0.7	0.9	-0.2	-0.7	-0.6	0.8	0.8	0.6	3.4	0.5
Worrier / anxious feelings	0.4	0.8	1.9	-0.5	0.8	1.0	0.9	1.0	0.3	1.4	1.0	1.0	0.9	-0.7	0.8
Medication for cholesterol, blood pressure or diabetes	0.4	0.6	1.4	-0.4	-0.6	-1.2	-0.9	-1.0	-0.8	-0.2	-0.8	-0.8	-0.8	0.6	-0.8
Body fat percentage	0.4	1.4	4.3	-0.4	1.3	1.6	1.5	0.4	0.6	0.4	1.3	1.2	1.2	2.1	1.1
Age at first live birth	0.4	0.7	1.2	0.4	-1.1	-0.8	-0.9	-0.4	-0.3	-1.1	-0.9	-1.1	-0.9	-0.3	-0.9
Medication: Omeprazole	0.4	0.5	1.5	1.2	0.3	0.5	0.4	0.8	1.1	0.8	0.5	0.4	0.5	0.3	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	3.6	0.3	-0.7	-0.2	-0.5	0.3	-0.2	-0.7	-0.5	-0.6	-0.5	-1.9	-0.4
Leg fat mass (right)	0.4	1.5	5.5	-1.3	1.4	1.5	1.4	0.3	0.1	-0.1	1.1	1.1	1.0	2.4	0.9
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.1	0.4	0.8	0.5	0.8	0.5	0.7	1.1	0.8	0.8	0.8	0.3	0.7
Medication: Aspirin	0.4	0.5	1.4	-0.6	-0.7	-0.6	-0.8	-0.3	-0.6	-1.2	-0.8	-0.7	-0.8	-0.8	-0.7
Average weekly red wine intake	0.4	0.6	2.3	-1.5	0.8	0.8	0.8	1.2	-0.2	-0.1	0.7	0.7	0.6	-0.2	0.5
Handedness (chirality/laterality): Left-handed	0.4	0.4	2.9	1.1	0.1	0.3	0.2	0.3	0.5	0.7	0.1	0.2	0.2	-1.7	0.4
Qualifications: nursing, teaching	0.4	0.7	6.0	-0.4	0.7	0.5	0.5	0.2	0.0	-0.2	0.5	0.6	0.5	2.5	0.4
Medication: Blood pressure	0.4	0.8	1.7	-0.0	-1.1	-0.5	-0.9	-0.8	-0.4	-1.3	-1.0	-1.1	-0.9	-0.5	-1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	2.4	-1.1	0.5	0.4	0.6	1.5	-0.3	-0.1	0.4	0.4	0.3	1.0	0.2
Leg fat percentage (left)	0.4	1.6	4.4	-0.6	1.5	1.6	1.5	0.8	0.6	0.4	1.3	1.3	1.2	2.1	1.1
Heart attack/myocardial infarction (self-reported)	0.4	0.6	1.8	-0.8	0.6	0.9	0.9	1.3	0.2	-0.6	0.8	0.7	0.7	-0.2	0.5
Leg fat mass (left)	0.4	1.4	5.5	-1.4	1.3	1.4	1.3	0.2	0.0	-0.2	1.1	1.0	0.9	2.4	0.8
Depression (Nagel 2018)	0.3	0.4	3.6	-1.9	0.1	-0.3	-0.0	0.5	-1.0	-0.1	-0.0	-0.0	-0.2	0.6	-0.2
Crohns Disease (2012)	0.3	0.4	2.1	0.3	-0.7	-0.5	-0.5	-1.4	-0.1	-0.8	-0.6	-0.7	-0.6	-0.1	-0.6
Triglycerides	0.3	0.4	0.6	0.3	0.7	0.7	0.6	0.4	0.7	0.6	0.8	0.8	0.8	-0.7	0.8
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	2.1	-1.4	0.1	-0.1	0.1	0.7	-0.8	-0.8	-0.0	-0.0	-0.2	0.9	-0.1
Supplements: Zinc	0.3	0.4	0.6	0.4	0.4	0.8	0.6	-0.6	0.5	0.7	0.7	0.5	0.6	-0.8	0.5
Pack years adult smoking proportion	0.3	0.4	0.7	-0.8	-0.6	-0.6	-0.7	-0.8	-0.8	-0.6	-0.6	-0.6	-0.6	-0.3	-0.7
Townsend deprivation index at recruitment	0.3	0.4	1.2	0.8	0.4	0.6	0.4	0.7	0.4	1.1	0.4	0.4	0.4	-0.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.6	-1.3	0.5	0.8	0.7	0.9	-0.3	0.3	0.7	0.6	0.5	-0.3	0.6
Mouth/teeth dental problems	0.3	0.5	1.5	-0.8	-0.6	-0.8	-0.7	-0.4	-0.8	-1.2	-0.6	-0.7	-0.6	0.2	-0.6
Weight	0.3	1.6	8.2	-1.8	1.4	1.2	1.2	-0.1	-0.3	-0.3	1.1	1.0	0.9	2.9	0.8
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.7	1.3	-0.7	-0.4	-0.4	-0.5	0.4	0.1	-0.6	-0.5	-0.4	-1.2	-0.4
High blood pressure (siblings)	0.3	0.5	0.9	0.7	1.0	0.7	0.6	-0.6	0.7	0.4	0.6	0.7	0.6	0.9	0.9
Whole body fat mass	0.3	1.1	4.8	-1.2	1.1	1.3	1.1	-0.0	0.0	-0.3	0.9	0.9	0.8	2.2	0.7
Suffer from ‘nerves’	0.3	0.4	1.2	-0.7	-0.7	-0.4	-0.6	-0.1	-0.7	-0.1	-0.8	-0.7	-0.8	-1.1	-0.5
Loneliness, isolation	0.3	0.5	2.0	-1.4	0.5	0.7	0.6	1.1	-0.4	-0.0	0.6	0.6	0.5	0.1	0.4
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	2.4	1.5	0.4	0.5	0.7	0.4	0.9	0.8	0.5	0.4	0.5	0.6	0.5
Back pain experienced in last month	0.3	0.5	2.9	-1.7	0.6	0.9	0.5	0.5	-0.4	-0.2	0.5	0.5	0.3	-0.5	0.3
Mineral and other dietary supplements	0.3	0.4	3.0	0.7	0.3	-0.0	0.0	0.4	0.6	-0.2	0.1	0.1	0.1	1.7	0.2
Supplements: Fish oil (including cod liver oil)	0.3	0.4	3.8	0.0	-0.4	0.1	-0.1	-0.2	-0.2	0.3	-0.2	-0.2	-0.2	-1.9	-0.2
Vascular/heart problems diagnosed by doctor	0.3	0.7	2.2	0.3	-0.7	-1.3	-0.9	-1.5	-0.6	0.6	-0.8	-0.7	-0.8	-0.6	-0.6
Basal cell carcinoma (self-reported)	0.3	0.3	2.1	1.5	-0.4	-0.7	-0.6	-0.1	0.4	-0.1	-0.4	-0.3	-0.3	0.6	-0.1
Pack years of smoking	0.3	0.4	0.6	-0.4	-0.6	-0.7	-0.7	-0.8	-0.6	-0.6	-0.6	-0.6	-0.6	-0.3	-0.7
Arm predicted mass (left)	0.3	1.3	5.9	-2.4	0.4	0.1	0.1	-0.8	-1.4	-1.2	-0.1	-0.0	-0.3	2.3	-0.3
Worry (Nagel 2018)	0.2	0.5	1.9	-1.4	0.3	0.7	0.4	1.0	-0.4	0.8	0.4	0.4	0.3	-1.1	0.3
Fasting Glucose	0.2	0.2	0.5	0.6	0.4	0.6	0.4	0.1	0.7	0.6	0.3	0.4	0.3	-0.3	0.4
Primary Biliary Cirrhosis	0.2	0.3	2.2	1.5	-0.1	-0.4	-0.5	-0.0	0.5	0.2	-0.7	-0.4	-0.5	0.3	-0.1
Height	0.2	3.2	7.1	-0.6	-1.8	-2.2	-1.9	-0.4	-1.5	-1.9	-1.7	-2.1	-1.7	2.7	-1.9
Hypothyroidism (self reported)	0.2	0.5	1.1	-0.1	0.7	1.0	0.7	0.7	0.2	1.0	0.7	0.7	0.6	-0.6	0.6
Lung FEV1/FVC ratio	0.2	1.1	7.8	2.8	0.1	0.3	0.4	-0.7	1.6	0.7	0.3	0.1	0.5	0.8	0.4
Ever had hysterectomy (womb removed)	0.2	0.2	1.3	1.1	0.0	0.3	0.0	0.1	0.7	0.1	0.0	0.0	0.1	1.0	0.1
Medication for hormone replacement therapy	0.2	0.2	0.6	-0.4	-0.4	0.1	-0.0	0.8	-0.4	-0.3	-0.2	-0.4	-0.2	-0.8	-0.5
Leg fat-free mass (left)	0.2	1.0	5.2	-1.9	0.4	0.1	0.0	-1.1	-0.9	-1.1	-0.0	-0.0	-0.2	2.3	-0.2
Trunk fat percentage	0.2	0.9	4.2	-0.3	1.0	1.2	1.1	0.1	0.5	0.2	0.9	0.8	0.9	2.1	0.8
Average weekly fortified wine intake	0.2	0.2	1.0	1.0	0.3	0.3	0.2	0.7	0.7	0.4	0.2	0.3	0.2	0.3	0.3
Fed-up feelings	0.2	0.3	1.4	-1.2	0.5	0.6	0.5	0.7	-0.4	0.1	0.3	0.4	0.2	-0.1	0.4
Relative age voice broke	0.2	0.2	1.2	0.2	-0.7	-0.2	-0.3	0.3	-0.5	0.0	-0.3	-0.6	-0.3	-1.1	-0.5
High blood pressure	0.2	0.5	1.3	0.1	0.6	1.2	0.7	1.1	0.7	-0.6	0.7	0.7	0.7	0.7	0.6
Leg predicted mass (left)	0.2	1.0	5.5	-1.9	0.4	0.2	0.1	-1.1	-0.9	-1.1	0.0	0.1	-0.1	2.3	-0.1
Trunk fat mass	0.2	1.0	5.6	-1.1	0.9	1.1	1.0	-0.2	-0.0	-0.3	0.8	0.7	0.7	2.4	0.6
Number of incorrect matches in round	0.2	0.3	0.9	0.8	0.5	0.4	0.3	0.8	0.7	1.0	0.4	0.5	0.5	-0.2	0.5
Trunk fat-free mass	0.2	1.3	6.2	-2.5	0.7	0.3	0.3	-0.5	-1.1	-1.1	0.2	0.3	0.0	2.4	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	2.1	-1.4	0.2	-0.0	0.0	1.0	-0.7	-0.1	-0.1	0.0	-0.2	0.3	0.0
Depression (self-reported)	0.2	0.2	1.7	-1.3	0.1	-0.0	0.1	0.1	-0.7	-0.2	-0.1	0.0	-0.1	-0.4	-0.3
Trunk predicted mass	0.2	1.2	5.8	-2.4	0.7	0.3	0.4	-0.4	-1.1	-1.1	0.3	0.3	0.1	2.4	0.0
Breastfed as a baby	0.2	0.2	0.4	-0.3	0.6	0.2	0.5	0.5	0.4	-0.1	0.5	0.6	0.5	0.7	0.5
Glaucoma (self-reported)	0.2	0.3	1.8	-1.4	0.3	0.1	0.2	0.7	-0.9	-0.1	0.1	0.2	0.0	-0.2	0.0
Gout (self-reported)	0.2	0.3	0.5	-0.3	-0.5	-0.7	-0.7	0.1	-0.7	-0.3	-0.6	-0.7	-0.6	0.4	-0.7
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.9	-0.2	0.5	0.9	0.8	0.8	0.2	0.9	0.7	0.6	0.7	-0.6	0.5
Arm fat-free mass (right)	0.2	1.1	7.0	-1.9	0.7	0.4	0.4	-0.3	-0.8	-1.0	0.3	0.3	0.1	2.6	0.1
Emphysema/chronic bronchitis	0.2	0.2	0.4	-0.6	-0.3	-0.5	-0.6	0.3	-0.6	-0.5	-0.6	-0.4	-0.6	-0.3	-0.4
Medication: Allopurinol	0.2	0.3	2.1	1.4	-0.3	-0.1	-0.3	0.4	0.4	-0.0	-0.3	-0.3	-0.2	-0.4	-0.2
Arm predicted mass (right)	0.2	1.2	6.9	-2.0	0.8	0.4	0.4	-0.3	-0.9	-1.0	0.3	0.3	0.1	2.6	0.1
Comparative height size at age 10	0.2	0.9	2.4	-0.8	-0.6	-1.1	-0.9	0.1	-1.1	-1.1	-0.7	-0.8	-0.8	1.6	-0.9
Overall health rating	0.2	0.5	3.7	-1.9	-0.1	0.2	0.2	0.1	-0.9	-0.8	0.0	-0.1	-0.1	-0.5	-0.3
Age at last live birth	0.2	0.3	0.5	0.6	-0.7	-0.5	-0.6	-0.1	-0.1	-0.6	-0.5	-0.6	-0.4	0.1	-0.6
Whole body fat-free mass	0.2	1.2	5.9	-2.2	0.6	0.2	0.2	-0.8	-1.1	-1.1	0.1	0.1	-0.1	2.4	-0.1
Leg fat-free mass (right)	0.2	1.0	5.3	-1.7	0.3	0.1	0.1	-1.1	-0.9	-1.1	-0.0	-0.0	-0.2	2.3	-0.2
Commuting to job workplace: Walk	0.2	0.2	0.9	0.9	0.0	0.2	0.3	0.1	0.7	0.4	0.3	0.2	0.4	-0.5	0.2
Osteoporosis (self-reported)	0.2	0.2	0.7	0.4	0.6	0.0	0.3	0.6	0.6	0.6	0.2	0.4	0.3	0.8	0.6
Medication: Gliclazide	0.2	0.2	1.1	-0.8	0.5	0.4	0.4	0.4	-0.2	-0.6	0.3	0.3	0.2	1.1	0.1
Whole body water mass	0.2	1.2	6.3	-2.2	0.7	0.3	0.3	-0.7	-1.0	-1.1	0.2	0.2	0.0	2.5	-0.0
Leg predicted mass (right)	0.2	1.0	5.4	-1.7	0.4	0.1	0.1	-1.0	-0.8	-1.1	0.0	0.0	-0.1	2.3	-0.1
Average weekly champagne plus white wine intake	0.2	0.3	1.1	0.6	0.3	0.2	0.3	0.7	0.5	-0.0	0.4	0.4	0.5	1.1	0.3
Medication: Bendroflumethiazide	0.2	0.4	1.6	-0.7	-0.5	-0.0	-0.3	0.0	-0.4	-1.1	-0.3	-0.3	-0.3	-1.3	-0.4
Medication: Lisinopril	0.2	0.2	0.5	0.6	0.6	0.7	0.5	0.1	0.7	0.3	0.4	0.5	0.4	0.1	0.6
Medication: Atorvastatin	0.2	0.2	0.8	0.6	0.1	0.3	0.4	0.9	0.3	-0.1	0.3	0.1	0.3	0.9	0.1
Illnesses of father: High blood pressure	0.2	0.3	0.8	0.7	0.4	0.9	0.4	-0.6	0.5	0.6	0.3	0.3	0.3	-0.5	0.4
Basal metabolic rate	0.2	1.3	7.2	-2.1	0.8	0.5	0.5	-0.7	-0.9	-0.9	0.4	0.4	0.2	2.7	0.1
Arm fat-free mass (left)	0.2	1.0	6.2	-1.9	0.7	0.4	0.3	-0.6	-0.9	-0.9	0.2	0.3	0.0	2.5	0.0
Average weekly beer plus cider intake	0.2	0.4	2.9	0.2	-0.4	-0.3	-0.4	-0.4	-0.2	0.3	-0.5	-0.3	-0.5	-1.7	-0.2
Supplements: Calcium	0.2	0.2	0.7	0.4	0.2	0.1	0.2	0.8	0.3	0.8	0.3	0.2	0.3	0.5	0.3
Heart disease (siblings)	0.2	0.2	0.8	-0.7	0.5	0.6	0.4	0.9	-0.2	0.4	0.2	0.4	0.2	-0.4	0.4
Age at First Birth	0.1	0.2	1.0	0.0	-0.5	-0.3	-0.3	-0.1	-0.3	-0.4	-0.4	-0.4	-0.4	-1.0	-0.4
Body Mass Index (BMI) (2010)	0.1	0.1	0.5	-0.2	0.4	0.5	0.4	-0.2	-0.1	-0.2	0.3	0.3	0.2	0.7	0.2
Mean Putamen Volume	0.1	0.1	0.3	-0.4	-0.2	-0.1	-0.0	-0.1	-0.3	-0.2	-0.1	-0.2	-0.2	0.5	-0.2
HDL Cholesterol	0.1	0.2	0.6	-0.1	0.4	0.3	0.5	0.7	0.3	0.7	0.4	0.4	0.4	0.8	0.4
Lupus	0.1	0.2	1.3	0.5	0.2	-0.5	-0.3	0.2	0.3	-0.1	-0.2	0.0	-0.1	1.1	0.2
Rheumatoid Arthritis	0.1	0.2	0.6	-0.7	-0.0	-0.1	0.1	-0.8	-0.2	-0.3	-0.0	0.0	-0.0	0.8	-0.1
Blood Eosinophil Count	0.1	0.4	1.6	-0.0	0.7	0.7	0.5	1.3	0.2	-0.2	0.5	0.6	0.4	0.9	0.5
Smoking Status	0.1	0.1	0.4	-0.6	0.5	0.6	0.3	-0.3	-0.4	-0.1	0.3	0.4	0.3	0.1	0.2
Hearing difficulty/problems: Yes	0.1	0.1	1.1	-0.5	0.3	0.0	0.2	1.1	-0.1	0.2	0.2	0.3	0.2	-0.1	0.2
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.8	0.7	-0.2	0.1	0.0	0.9	0.2	0.2	-0.1	-0.2	-0.1	0.2	-0.1
Systolic blood pressure, automated reading	0.1	0.2	0.9	-0.4	-0.4	-0.0	-0.3	0.3	-0.3	-0.6	-0.2	-0.2	-0.2	-1.0	-0.4
Eye problems/disorders: Diabetes related eye disease	0.1	0.1	0.5	-0.5	0.3	0.2	0.2	-0.4	-0.2	-0.1	0.1	0.2	0.1	0.7	0.1
Angina	0.1	0.1	0.5	0.1	0.2	0.5	0.5	0.7	0.4	-0.1	0.3	0.2	0.3	0.1	0.2
Age when periods started (menarche)	0.1	0.3	1.7	1.3	-0.3	-0.3	-0.4	0.8	0.4	0.7	-0.2	-0.1	-0.1	-0.7	0.1
Chronic bronchitis/emphysema (father)	0.1	0.1	0.7	0.4	0.0	0.1	0.1	0.8	0.3	0.1	0.1	0.1	0.1	0.0	0.1
Pain all over the body in last month	0.1	0.1	0.2	-0.4	-0.1	-0.3	-0.3	-0.2	-0.4	0.0	-0.3	-0.2	-0.4	-0.3	-0.4
Illnesses of siblings	0.1	0.1	0.8	0.1	-0.1	-0.0	0.3	0.9	0.2	0.1	0.3	0.1	0.3	0.2	-0.1
Alcohol intake versus 10 years previously	0.1	0.1	0.6	0.3	0.2	0.3	0.3	-0.1	0.4	0.3	0.2	0.3	0.2	-0.7	0.4
Hair/balding pattern: Pattern 3	0.1	0.2	0.5	-0.1	0.2	0.6	0.6	0.7	0.2	0.2	0.5	0.4	0.5	-0.2	0.2
Number of live births	0.1	0.1	0.6	0.8	-0.4	-0.2	-0.3	-0.1	0.1	0.0	-0.2	-0.2	-0.2	-0.7	-0.2
Medication: Lansoprazole	0.1	0.2	0.7	-0.3	0.3	0.6	0.3	0.4	0.1	0.2	0.3	0.3	0.2	-0.8	0.3
Prospective memory result	0.1	0.2	1.6	-0.2	-0.2	0.1	-0.1	-0.1	-0.4	-0.2	-0.2	-0.2	-0.2	-1.3	-0.2
Illnesses of mother	0.1	0.1	0.4	-0.6	0.2	0.4	0.1	0.2	-0.2	-0.3	0.1	0.0	0.0	0.2	0.0
Chronic bronchitis/emphysema (mother)	0.1	0.1	0.2	0.1	0.4	0.4	0.3	0.5	0.2	0.3	0.2	0.3	0.2	-0.1	0.3
Medication: Blood pressure	0.1	0.2	0.6	0.7	0.2	0.6	0.4	0.5	0.8	-0.0	0.5	0.5	0.5	-0.2	0.5
Angina (self-reported)	0.1	0.1	0.5	0.1	0.1	0.4	0.4	0.7	0.4	-0.1	0.2	0.1	0.2	0.0	0.1
Number of full sisters	0.1	0.1	0.3	0.1	0.4	0.1	0.2	-0.5	0.2	0.2	0.3	0.4	0.3	0.4	0.4
Hypertension (Self-reported)	0.1	0.2	0.9	-0.4	0.0	0.6	0.2	0.5	0.1	-1.0	0.2	0.1	0.1	0.2	0.0
Mood swings	0.1	0.2	0.5	-0.6	-0.5	-0.4	-0.3	0.3	-0.7	-0.3	-0.4	-0.5	-0.5	0.0	-0.4
Eye problems/disorders: Cataract	0.1	0.1	0.9	-0.1	0.2	0.2	0.2	0.1	0.1	0.2	0.1	0.1	0.1	1.0	0.2
Medication for cholesterol	0.1	0.1	0.4	-0.0	0.4	-0.5	-0.2	-0.3	-0.1	0.6	0.1	0.4	0.1	0.6	0.3
Blood Red Count	0.0	0.3	0.8	-0.1	-0.5	-0.3	-0.5	-0.4	-0.3	-0.9	-0.5	-0.5	-0.6	-0.9	-0.6
Heel T-Score	0.0	0.1	0.4	-0.2	0.3	0.6	0.5	0.4	0.5	0.1	0.5	0.3	0.5	-0.1	0.2
Hair Pigment	0.0	1.2	7.5	-2.7	0.6	1.2	1.1	0.8	-0.7	0.0	1.1	0.9	0.9	-0.5	0.4
Relative age of first facial hair	0.0	0.1	0.1	-0.0	-0.3	0.1	-0.1	-0.3	-0.2	0.3	-0.1	-0.3	-0.1	-0.3	-0.2
Illnesses of siblings: Diabetes	0.0	0.0	0.1	0.3	-0.1	-0.2	-0.1	0.3	0.1	-0.2	-0.2	-0.2	-0.2	-0.2	-0.1
Diastolic blood pressure, automated reading	0.0	0.2	0.3	-0.1	-0.4	0.1	-0.5	-0.5	-0.3	-0.6	-0.4	-0.5	-0.4	-0.1	-0.4

Hub : Genes

CYSTM1

Models

Trait associations