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chr7:126,529,931-128,425,768

Best TWAS P=2.97e-10 · Best GWAS P=1.79e-12 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
18	GTEx	Skin Sun Exposed Lower leg	SND1	0.10	0.08	lasso	4	0.06	1.2e-05	6.2	-6.3	3.0e-10	0.35	0.37	0.60	TRUE
20	ROSMAP	Brain Pre-frontal Cortex	GCC1	0.05	0.01	enet	18	0.03	1.7e-04	-4.3	6.2	6.8e-10	-0.35	0.76	0.14	TRUE
12	GTEx	Esophagus Muscularis	SND1	0.17	0.08	lasso	5	0.13	4.8e-08	5.5	-6.2	7.1e-10	0.17	0.92	0.04	TRUE
16	GTEx	Nerve Tibial	GCC1	0.09	0.06	lasso	3	0.05	1.7e-04	-5.3	6.0	2.2e-09	-0.72	0.36	0.46	TRUE
3	GTEx	Adipose Visceral Omentum	SND1	0.17	0.15	lasso	3	0.14	6.0e-08	5.4	-5.8	7.1e-09	0.27	0.94	0.04	TRUE
15	GTEx	Nerve Tibial	LRRC4	0.07	0.00	lasso	6	0.02	1.3e-02	-3.0	-5.8	8.5e-09	0.26	0.18	0.68	TRUE
26	The Cancer Genome Atlas	Lung Adenocarcinoma	ZNF800	0.06	0.01	enet	15	0.03	4.9e-04	5.8	-5.8	8.8e-09	0.48	0.06	0.51	TRUE
23	The Cancer Genome Atlas	Glioblastoma Multiforme	SND1	0.15	0.09	blup	198	0.06	8.7e-03	5.9	-5.7	1.3e-08	0.20	0.04	0.82	TRUE
5	GTEx	Artery Coronary	SND1	0.20	0.26	lasso	1	0.25	6.1e-09	5.3	-5.3	1.2e-07	0.19	0.89	0.04	TRUE
1	CommonMind	Brain Pre-frontal Cortex	LRRC4	0.03	0.00	bslmm	387	0.00	8.6e-02	-6.6	6.2	7.3e-10	-0.57	0.04	0.68	FALSE
13	GTEx	Lung	SND1	0.11	0.00	enet	16	0.03	3.7e-03	5.4	-6.2	7.4e-10	0.08	0.36	0.11	FALSE
4	GTEx	Artery Aorta	SND1	0.09	0.10	lasso	3	0.08	2.2e-05	5.3	-6.0	1.9e-09	0.25	0.82	0.08	FALSE
8	GTEx	Brain Cortex	GCC1	0.22	0.13	lasso	5	0.05	1.9e-02	-5.3	6.0	2.3e-09	-0.62	0.18	0.29	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	SND1	0.21	0.05	enet	26	0.05	7.9e-03	5.5	-6.0	2.3e-09	0.31	0.38	0.18	FALSE
17	GTEx	Nerve Tibial	SND1	0.23	0.20	lasso	5	0.19	3.0e-13	5.4	-5.9	3.2e-09	0.25	0.98	0.02	FALSE
10	GTEx	Colon Sigmoid	SND1	0.25	0.18	lasso	4	0.16	2.0e-06	5.4	-5.8	5.9e-09	0.26	0.91	0.05	FALSE
25	The Cancer Genome Atlas	Brain Lower Grade Glioma	SND1	0.09	0.09	lasso	2	0.08	1.8e-09	5.4	-5.8	7.3e-09	0.24	0.59	0.41	FALSE
19	METSIM	Adipose	GCC1	0.05	0.02	bslmm	468	0.02	1.8e-04	-5.3	5.6	2.0e-08	-0.72	0.08	0.92	FALSE
7	GTEx	Brain Cerebellar Hemisphere	LRRC4	0.14	0.09	lasso	7	0.04	3.4e-02	6.2	5.5	3.1e-08	-0.31	0.07	0.55	FALSE
6	GTEx	Artery Tibial	SND1	0.20	0.23	lasso	5	0.24	4.9e-19	5.4	-5.5	4.7e-08	0.21	0.98	0.02	FALSE
14	GTEx	Muscle Skeletal	SND1	0.05	0.05	lasso	3	0.04	1.0e-04	5.4	-5.4	5.4e-08	0.18	0.83	0.02	FALSE
22	YFS	Blood	SND1	0.03	0.02	lasso	2	0.02	7.8e-08	5.4	-5.4	6.7e-08	0.21	0.98	0.02	FALSE
21	ROSMAP	Brain Pre-frontal Cortex	SND1	0.06	0.02	lasso	7	0.02	2.4e-03	5.4	-5.4	8.8e-08	0.23	0.82	0.04	FALSE
9	GTEx	Cells Transformed fibroblasts	SND1	0.24	0.21	lasso	7	0.20	4.9e-15	5.4	-5.3	1.1e-07	0.19	0.98	0.02	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	GCC1	0.05	0.07	lasso	3	0.06	1.2e-07	-5.3	5.3	1.1e-07	-0.61	0.76	0.24	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SND1	0.08	0.07	lasso	4	0.07	2.2e-08	5.2	-5.3	1.3e-07	0.22	0.99	0.01	FALSE