[Hub]/) : Traits : Verbal and Numeric Reasoning (VNR) :

chr17:34,146,026-35,675,511

Best TWAS P=3.02e-10 · Best GWAS P=2.39e-09 conditioned to 0.147

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex DHRS11 0.22 0.24 bslmm 311 0.25 1.6e-30 5.5 -5.3 8.8e-08 0.62 0.10 0.90 FALSE
2 CommonMind Brain Pre-frontal Cortex MYO19 0.05 0.05 lasso 2 0.05 8.4e-07 5.5 -5.7 1.6e-08 0.86 0.04 0.96 FALSE
3 GTEx Adipose Subcutaneous GGNBP2 0.10 0.11 enet 9 0.11 3.5e-09 -6.0 6.2 4.1e-10 -0.97 0.01 0.99 FALSE
4 GTEx Adipose Subcutaneous MYO19 0.07 0.05 enet 10 0.03 1.3e-03 -5.7 -5.6 2.6e-08 0.96 0.02 0.98 FALSE
5 GTEx Adipose Visceral Omentum GGNBP2 0.13 0.12 enet 11 0.13 1.9e-07 5.6 5.7 1.6e-08 -0.86 0.02 0.98 FALSE
6 GTEx Artery Aorta GGNBP2 0.13 0.12 lasso 4 0.12 2.4e-07 5.5 5.8 6.4e-09 -0.83 0.02 0.98 FALSE
7 GTEx Artery Aorta DHRS11 0.10 0.07 lasso 5 0.06 2.7e-04 5.5 -5.5 3.4e-08 0.76 0.04 0.94 FALSE
8 GTEx Artery Aorta MYO19 0.20 0.16 enet 9 0.15 1.6e-08 5.5 -6.1 9.1e-10 0.93 0.03 0.97 FALSE
9 GTEx Artery Tibial GGNBP2 0.12 0.12 enet 15 0.12 1.2e-09 5.5 5.8 6.9e-09 -0.86 0.04 0.96 FALSE
10 GTEx Artery Tibial DHRS11 0.14 0.08 enet 11 0.11 7.1e-09 5.2 -5.7 9.3e-09 0.88 0.02 0.98 FALSE
11 GTEx Artery Tibial MYO19 0.12 0.11 lasso 6 0.13 4.1e-10 -5.6 -5.9 3.7e-09 0.93 0.05 0.95 FALSE
12 GTEx Brain Caudate basal ganglia DHRS11 0.18 0.12 lasso 4 0.02 9.2e-02 5.3 -5.5 4.8e-08 0.75 0.03 0.78 FALSE
13 GTEx Brain Cerebellar Hemisphere CTB-75G16.3 0.27 0.14 lasso 4 0.05 1.8e-02 5.5 5.3 8.6e-08 -0.72 0.03 0.72 FALSE
14 GTEx Brain Cerebellum DHRS11 0.33 0.23 lasso 4 0.20 1.9e-06 5.5 -5.5 5.0e-08 0.75 0.10 0.88 FALSE
15 GTEx Brain Cortex DHRS11 0.23 0.18 enet 24 0.18 8.5e-06 5.5 -5.5 3.0e-08 0.75 0.04 0.95 FALSE
16 GTEx Brain Cortex CTB-75G16.3 0.32 0.15 lasso 8 0.14 1.4e-04 5.5 5.4 8.4e-08 -0.75 0.08 0.73 FALSE
17 GTEx Brain Hypothalamus DHRS11 0.24 0.12 lasso 2 0.12 1.1e-03 5.9 -5.9 2.9e-09 0.82 0.02 0.91 FALSE
18 GTEx Brain Nucleus accumbens basal ganglia DHRS11 0.18 0.20 lasso 3 0.15 8.8e-05 5.2 -5.2 1.8e-07 0.75 0.04 0.93 FALSE
19 GTEx Breast Mammary Tissue CTB-75G16.3 0.12 0.04 enet 9 0.06 7.2e-04 -4.3 5.3 1.5e-07 -0.58 0.11 0.73 FALSE
20 GTEx Cells EBV-transformed lymphocytes GGNBP2 0.13 0.15 lasso 2 0.13 5.5e-05 5.9 5.9 3.1e-09 -0.82 0.02 0.96 FALSE
21 GTEx Cells EBV-transformed lymphocytes DHRS11 0.14 0.08 enet 3 0.07 3.2e-03 5.9 -5.9 3.9e-09 0.82 0.02 0.91 FALSE
22 GTEx Cells EBV-transformed lymphocytes ZNHIT3 0.31 0.32 enet 9 0.22 1.1e-07 -5.7 -5.9 3.5e-09 0.98 0.02 0.98 FALSE
23 GTEx Cells Transformed fibroblasts GGNBP2 0.11 0.10 enet 12 0.10 4.5e-08 5.8 5.7 1.0e-08 -0.81 0.01 0.99 FALSE
24 GTEx Cells Transformed fibroblasts DHRS11 0.11 0.08 lasso 2 0.08 2.7e-06 5.5 -5.2 2.4e-07 0.72 0.07 0.93 FALSE
25 GTEx Cells Transformed fibroblasts ZNHIT3 0.15 0.07 lasso 7 0.05 1.7e-04 -5.8 -5.8 7.0e-09 0.96 0.02 0.97 FALSE
26 GTEx Colon Transverse GGNBP2 0.15 0.15 enet 13 0.11 4.8e-06 5.5 5.3 1.0e-07 -0.76 0.09 0.91 FALSE
27 GTEx Colon Transverse MYO19 0.13 0.12 lasso 2 0.11 8.0e-06 -5.8 -5.5 3.7e-08 0.83 0.02 0.98 FALSE
28 GTEx Esophagus Gastroesophageal Junction GGNBP2 0.12 0.12 lasso 2 0.09 4.9e-04 5.5 5.5 3.5e-08 -0.75 0.06 0.83 FALSE
29 GTEx Esophagus Mucosa GGNBP2 0.16 0.16 enet 15 0.18 3.1e-12 5.4 5.9 4.6e-09 -0.90 0.03 0.97 FALSE
30 GTEx Esophagus Mucosa DHRS11 0.12 0.08 lasso 2 0.06 5.1e-05 -5.8 -5.9 3.3e-09 0.90 0.02 0.98 FALSE
31 GTEx Esophagus Mucosa ZNHIT3 0.22 0.13 enet 15 0.08 8.1e-06 -5.7 -5.4 6.5e-08 0.87 0.02 0.98 FALSE
32 GTEx Esophagus Mucosa MYO19 0.11 0.08 enet 12 0.04 1.2e-03 -5.7 -5.8 6.8e-09 0.96 0.01 0.98 FALSE
33 GTEx Esophagus Muscularis GGNBP2 0.15 0.11 enet 13 0.14 1.4e-08 -6.0 5.8 8.4e-09 -0.86 0.01 0.99 FALSE
34 GTEx Esophagus Muscularis DHRS11 0.14 0.08 lasso 5 0.08 8.2e-06 5.8 -6.2 7.1e-10 0.92 0.01 0.99 FALSE
35 GTEx Esophagus Muscularis MYO19 0.14 0.14 enet 8 0.15 2.8e-09 -5.8 -6.0 1.5e-09 0.97 0.02 0.98 FALSE
36 GTEx Heart Atrial Appendage MYO19 0.13 0.12 lasso 1 0.11 1.1e-05 5.8 -5.8 5.2e-09 0.81 0.02 0.97 FALSE
37 GTEx Heart Left Ventricle DHRS11 0.13 0.10 lasso 1 0.08 3.3e-05 5.6 -5.6 2.2e-08 0.78 0.06 0.94 FALSE
38 GTEx Heart Left Ventricle MYO19 0.10 0.06 lasso 3 0.04 5.4e-03 -5.8 -6.2 6.7e-10 0.89 0.02 0.95 FALSE
39 GTEx Lung GGNBP2 0.08 0.01 enet 8 0.01 3.3e-02 -5.8 6.2 6.3e-10 -0.91 0.02 0.98 FALSE
40 GTEx Lung DHRS11 0.09 0.08 lasso 5 0.10 3.7e-08 5.2 -5.8 9.2e-09 0.85 0.06 0.94 FALSE
41 GTEx Lung MYO19 0.15 0.14 enet 8 0.13 2.1e-10 -5.7 -5.8 6.9e-09 0.97 0.03 0.97 FALSE
42 GTEx Muscle Skeletal GGNBP2 0.08 0.06 enet 14 0.05 2.5e-05 5.4 6.3 3.0e-10 -0.81 0.02 0.98 TRUE
43 GTEx Muscle Skeletal DHRS11 0.09 0.08 lasso 3 0.09 9.3e-09 5.2 -5.6 2.2e-08 0.80 0.03 0.97 FALSE
44 GTEx Muscle Skeletal MYO19 0.04 0.05 enet 14 0.03 6.4e-04 5.5 -5.5 4.4e-08 0.84 0.03 0.96 FALSE
45 GTEx Nerve Tibial GGNBP2 0.10 0.04 lasso 3 0.05 2.4e-04 -6.0 6.2 5.6e-10 -0.98 0.01 0.98 FALSE
46 GTEx Nerve Tibial MYO19 0.11 0.11 enet 8 0.08 1.4e-06 -5.6 -5.7 1.0e-08 0.96 0.03 0.97 FALSE
47 GTEx Pancreas GGNBP2 0.15 0.09 lasso 2 0.07 5.1e-04 5.4 5.7 1.6e-08 -0.81 0.05 0.94 FALSE
48 GTEx Skin Sun Exposed Lower leg GGNBP2 0.11 0.06 enet 11 0.10 1.3e-08 5.4 5.7 1.2e-08 -0.87 0.03 0.97 FALSE
49 GTEx Skin Sun Exposed Lower leg MYO19 0.07 0.01 enet 7 0.03 1.8e-03 -5.6 -6.0 2.2e-09 0.90 0.03 0.97 FALSE
50 GTEx Stomach GGNBP2 0.13 0.06 lasso 3 0.06 5.9e-04 5.5 5.7 1.5e-08 -0.84 0.03 0.93 FALSE
51 GTEx Testis GGNBP2 0.19 0.19 lasso 1 0.15 3.8e-07 5.6 5.6 2.2e-08 -0.78 0.08 0.91 FALSE
52 GTEx Testis ZNHIT3 0.27 0.33 lasso 2 0.32 8.0e-15 -5.7 5.7 9.4e-09 -0.97 0.02 0.98 FALSE
53 GTEx Thyroid GGNBP2 0.07 0.06 lasso 2 0.04 2.8e-04 5.5 5.7 1.3e-08 -0.81 0.06 0.92 FALSE
54 GTEx Thyroid MYO19 0.11 0.05 lasso 3 0.04 7.1e-04 5.5 -5.5 3.0e-08 0.83 0.03 0.93 FALSE
55 GTEx Thyroid CTB-75G16.3 0.11 0.03 enet 15 0.04 4.6e-04 5.4 5.2 2.4e-07 -0.54 0.13 0.85 FALSE
56 GTEx Whole Blood GGNBP2 0.08 0.01 lasso 4 0.01 3.6e-02 5.8 5.9 4.2e-09 -0.80 0.02 0.92 FALSE
57 METSIM Adipose GGNBP2 0.16 0.14 lasso 5 0.14 6.2e-21 -5.7 5.9 3.5e-09 -0.97 0.02 0.98 FALSE
58 METSIM Adipose MYO19 0.10 0.10 lasso 4 0.10 1.6e-14 -5.8 -6.0 1.7e-09 0.97 0.01 0.99 FALSE
59 NTR Blood GGNBP2 0.03 0.02 bslmm 331 0.02 7.7e-07 5.4 5.4 6.4e-08 -0.81 0.03 0.97 FALSE
60 YFS Blood DHRS11 0.05 0.06 lasso 7 0.06 2.5e-18 5.6 -5.6 1.7e-08 0.86 0.06 0.94 FALSE
61 YFS Blood GGNBP2 0.07 0.09 enet 21 0.10 4.7e-31 -5.6 5.9 4.6e-09 -0.93 0.02 0.98 FALSE
62 YFS Blood MYO19 0.12 0.14 enet 14 0.14 4.0e-45 -5.7 -5.5 5.0e-08 0.97 0.02 0.98 FALSE
63 The Cancer Genome Atlas Colon Adenocarcinoma GGNBP2 0.10 0.05 lasso 3 0.06 2.5e-04 5.4 5.4 7.4e-08 -0.90 0.01 0.94 FALSE
64 The Cancer Genome Atlas Colon Adenocarcinoma MRM1 0.06 0.06 enet 4 0.05 9.4e-04 5.5 5.5 3.9e-08 -0.76 0.00 0.94 FALSE
65 The Cancer Genome Atlas Esophageal Carcinoma ZNHIT3 0.11 0.11 lasso 4 0.09 6.2e-04 5.5 -5.5 5.1e-08 0.74 0.02 0.64 FALSE
66 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma ZNHIT3 0.05 0.03 enet 4 0.04 4.7e-05 -5.8 -6.0 1.8e-09 0.88 0.01 0.99 FALSE
67 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DHRS11 0.04 0.04 lasso 2 0.04 3.1e-05 5.5 -5.5 3.9e-08 0.76 0.01 0.97 FALSE
68 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma GGNBP2 0.04 0.04 enet 3 0.04 6.3e-05 -6.0 6.1 8.9e-10 -0.95 0.01 0.99 FALSE
69 The Cancer Genome Atlas Brain Lower Grade Glioma DHRS11 0.05 0.11 enet 6 0.10 7.4e-12 5.6 -5.7 1.4e-08 0.79 0.02 0.98 FALSE
70 The Cancer Genome Atlas Liver Hepatocellular Carcinoma GGNBP2 0.05 0.04 lasso 2 0.01 8.1e-02 5.4 5.5 3.8e-08 -0.76 0.02 0.61 FALSE
71 The Cancer Genome Atlas Lung Squamous Cell Carcinoma ZNHIT3 0.03 0.03 enet 4 0.03 1.8e-04 5.5 -5.7 9.5e-09 0.79 0.02 0.89 FALSE
72 The Cancer Genome Atlas Prostate Adenocarcinoma GGNBP2 0.02 0.02 enet 4 0.02 6.0e-03 5.4 5.8 7.9e-09 -0.92 0.01 0.84 FALSE
73 The Cancer Genome Atlas Stomach Adenocarcinoma ZNHIT3 0.06 0.03 enet 2 0.04 1.3e-03 5.8 -5.8 7.7e-09 0.80 0.01 0.96 FALSE
74 The Cancer Genome Atlas Thyroid Carcinoma GGNBP2 0.04 0.04 enet 6 0.05 1.4e-05 5.3 5.7 1.5e-08 -0.82 0.02 0.94 FALSE