[Hub]/) : Traits : Verbal and Numeric Reasoning (VNR) : ←

chr22:41,531,236-43,229,137

Best TWAS P=1.74e-10 · Best GWAS P=2.22e-08 conditioned to 0.734

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
43	The Cancer Genome Atlas	Lung Adenocarcinoma	WBP2NL	0.05	0.04	blup	142	0.04	1.2e-05	-5.3	-6.4	1.7e-10	-0.85	0.01	0.97	TRUE
39	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CCDC134	0.08	0.04	enet	7	0.06	2.3e-04	-4.6	-5.8	8.0e-09	-0.35	0.00	0.50	FALSE
55	The Cancer Genome Atlas	Thyroid Carcinoma	WBP2NL	0.08	0.01	enet	11	0.03	3.0e-04	4.5	-5.7	1.4e-08	-0.66	0.06	0.85	FALSE
10	GTEx	Breast Mammary Tissue	CYP2D6	0.14	0.00	enet	28	0.02	3.4e-02	3.0	5.6	1.8e-08	0.41	0.08	0.41	FALSE
22	GTEx	Nerve Tibial	NAGA	0.12	0.09	lasso	6	0.08	1.8e-06	-5.4	-5.6	1.9e-08	-0.89	0.02	0.98	FALSE
5	GTEx	Artery Tibial	NAGA	0.07	0.05	lasso	4	0.05	1.6e-04	-5.2	-5.6	2.4e-08	-0.94	0.02	0.98	FALSE
19	GTEx	Liver	RP1-257I20.14	0.31	0.09	enet	19	0.06	1.1e-02	-5.4	-5.6	2.5e-08	-0.65	0.04	0.82	FALSE
13	GTEx	Cells Transformed fibroblasts	NAGA	0.12	0.15	lasso	7	0.15	1.3e-11	-5.2	-5.6	2.7e-08	-0.87	0.03	0.97	FALSE
6	GTEx	Brain Caudate basal ganglia	CYP2D6	0.47	0.42	enet	18	0.43	1.1e-13	-5.2	5.5	3.5e-08	0.84	0.03	0.97	FALSE
1	CommonMind	Brain Pre-frontal Cortex	WBP2NL	0.28	0.25	enet	16	0.35	1.3e-43	-5.2	-5.5	3.6e-08	-0.82	0.02	0.98	FALSE
7	GTEx	Brain Hippocampus	CYP2D6	0.39	0.22	lasso	9	0.32	2.9e-08	-5.2	5.5	3.7e-08	0.78	0.04	0.96	FALSE
42	The Cancer Genome Atlas	Brain Lower Grade Glioma	WBP2NL	0.08	0.05	lasso	4	0.08	1.5e-09	-5.2	-5.5	4.0e-08	-0.86	0.01	0.99	FALSE
31	GTEx	Thyroid	SLC25A5P1	0.11	0.08	enet	13	0.07	3.2e-06	4.5	-5.4	6.2e-08	-0.60	0.31	0.67	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	CYP2D6	0.44	0.38	enet	17	0.37	6.4e-11	-5.2	5.4	6.4e-08	0.86	0.03	0.97	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	WBP2NL	0.04	0.03	lasso	8	0.03	5.6e-04	-5.2	-5.4	7.1e-08	-0.89	0.01	0.97	FALSE
16	GTEx	Esophagus Muscularis	NAGA	0.07	0.08	lasso	2	0.06	9.4e-05	-5.2	-5.4	7.4e-08	-0.88	0.03	0.94	FALSE
28	GTEx	Stomach	CYP2D6	0.38	0.25	lasso	6	0.27	3.1e-13	-5.2	5.4	8.0e-08	0.81	0.03	0.97	FALSE
17	GTEx	Liver	OLA1P1	0.37	0.40	lasso	1	0.35	1.7e-10	-5.4	-5.4	8.1e-08	-0.86	0.01	0.98	FALSE
18	GTEx	Liver	NDUFA6-AS1	0.38	0.25	enet	12	0.28	2.0e-08	-5.4	-5.4	8.3e-08	-0.88	0.02	0.98	FALSE
23	GTEx	Nerve Tibial	SLC25A5P1	0.11	0.08	lasso	5	0.06	2.9e-05	4.5	-5.3	9.0e-08	-0.73	0.05	0.94	FALSE
3	GTEx	Artery Aorta	NAGA	0.08	0.07	lasso	3	0.07	1.7e-04	-5.2	-5.3	1.2e-07	-0.89	0.03	0.94	FALSE
12	GTEx	Cells EBV-transformed lymphocytes	CYP2D6	0.25	0.16	lasso	7	0.12	7.7e-05	-5.2	5.3	1.2e-07	0.88	0.03	0.96	FALSE
32	ROSMAP	Brain Pre-frontal Cortex	NAGA	0.08	0.10	lasso	4	0.09	7.3e-12	-5.2	-5.3	1.2e-07	-0.91	0.02	0.98	FALSE
21	GTEx	Muscle Skeletal	RP1-257I20.14	0.12	0.05	enet	18	0.08	7.6e-08	-2.6	-5.3	1.3e-07	-0.65	0.06	0.94	FALSE
25	GTEx	Pituitary	CYP2D6	0.42	0.42	lasso	6	0.39	1.0e-10	-5.2	5.3	1.3e-07	0.88	0.03	0.97	FALSE
40	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	NAGA	0.08	0.07	enet	5	0.07	1.1e-04	-5.2	-5.3	1.4e-07	-0.92	0.01	0.98	FALSE
20	GTEx	Lung	CYP2D6	0.28	0.28	lasso	4	0.26	1.3e-19	-5.2	5.3	1.5e-07	0.85	0.03	0.97	FALSE
24	GTEx	Pancreas	CYP2D6	0.48	0.34	lasso	3	0.36	6.5e-16	-5.2	5.2	1.5e-07	0.88	0.03	0.97	FALSE
11	GTEx	Breast Mammary Tissue (Male)	CYP2D6	0.34	-0.01	lasso	6	0.00	3.2e-01	-5.3	5.2	1.6e-07	0.81	0.03	0.77	FALSE
26	GTEx	Skin Not Sun Exposed Suprapubic	CYP2D6	0.27	0.31	lasso	3	0.31	2.7e-17	-5.2	5.2	1.6e-07	0.88	0.03	0.97	FALSE
33	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	CYP2D6	0.14	0.15	enet	2	0.15	1.1e-12	-5.2	5.2	1.6e-07	0.86	0.00	1.00	FALSE
46	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	CYP2D6	0.23	0.18	enet	2	0.18	1.3e-07	-5.2	5.2	1.6e-07	0.87	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Rectum Adenocarcinoma	CYP2D6	0.22	0.21	lasso	2	0.18	4.1e-05	-5.2	5.2	1.6e-07	0.87	0.00	0.92	FALSE
34	The Cancer Genome Atlas	Breast Invasive Carcinoma	CYP2D6	0.12	0.12	enet	2	0.13	8.8e-25	-5.2	5.2	1.7e-07	0.85	0.00	1.00	FALSE
36	The Cancer Genome Atlas	Glioblastoma Multiforme	CYP2D6	0.28	0.26	lasso	2	0.25	4.5e-08	-5.2	5.2	1.7e-07	0.88	0.00	1.00	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	CYP2D6	0.22	0.24	enet	2	0.25	2.8e-26	-5.2	5.2	1.7e-07	0.85	0.00	1.00	FALSE
14	GTEx	Colon Transverse	CYP2D6	0.23	0.21	lasso	5	0.23	4.1e-11	-5.2	5.2	1.8e-07	0.87	0.03	0.97	FALSE
15	GTEx	Esophagus Mucosa	CYP2D6	0.29	0.41	lasso	6	0.38	6.0e-27	-5.2	5.2	1.9e-07	0.89	0.03	0.97	FALSE
41	The Cancer Genome Atlas	Brain Lower Grade Glioma	FAM109B	0.04	0.03	lasso	3	0.03	8.7e-05	-5.2	-5.2	1.9e-07	-0.92	0.00	0.98	FALSE
54	The Cancer Genome Atlas	Thyroid Carcinoma	NAGA	0.10	0.14	lasso	4	0.14	6.1e-14	-5.2	-5.2	2.0e-07	-0.89	0.01	0.99	FALSE
29	GTEx	Testis	SREBF2	0.25	0.03	lasso	12	0.04	4.6e-03	-5.2	-5.2	2.2e-07	-0.77	0.04	0.94	FALSE
4	GTEx	Artery Tibial	CYP2D6	0.29	0.23	lasso	6	0.28	1.5e-22	-5.2	5.2	2.3e-07	0.76	0.03	0.97	FALSE
35	The Cancer Genome Atlas	Esophageal Carcinoma	CYP2D6	0.14	0.11	lasso	1	0.11	1.9e-04	-5.2	5.2	2.3e-07	0.89	0.00	0.85	FALSE
37	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CYP2D6	0.21	0.20	lasso	1	0.20	2.2e-22	-5.2	5.2	2.3e-07	0.89	0.00	1.00	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	CYP2D6	0.14	0.15	enet	2	0.17	1.4e-18	-5.2	5.2	2.3e-07	0.82	0.00	1.00	FALSE
52	The Cancer Genome Atlas	Testicular Germ Cell Tumors	CYP2D6	0.42	0.31	lasso	1	0.31	9.7e-12	-5.2	5.2	2.3e-07	0.89	0.00	1.00	FALSE
53	The Cancer Genome Atlas	Thyroid Carcinoma	CYP2D6	0.35	0.31	lasso	1	0.31	7.8e-31	-5.2	5.2	2.3e-07	0.89	0.00	1.00	FALSE
45	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	CYP2D6	0.19	0.13	enet	2	0.14	1.6e-06	-5.2	5.2	2.4e-07	0.82	0.00	0.99	FALSE
9	GTEx	Brain Putamen basal ganglia	CYP2D6	0.45	0.20	enet	18	0.32	2.9e-08	-5.2	5.2	2.5e-07	0.82	0.04	0.96	FALSE
30	GTEx	Thyroid	NAGA	0.10	0.17	lasso	5	0.17	9.8e-13	-5.4	-5.2	2.5e-07	-0.87	0.02	0.98	FALSE
44	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	CYP2D6	0.20	0.23	enet	2	0.25	3.4e-28	-5.2	5.2	2.5e-07	0.81	0.00	1.00	FALSE
51	The Cancer Genome Atlas	Stomach Adenocarcinoma	CYP2D6	0.12	0.10	blup	2	0.10	6.5e-08	-5.2	5.2	2.5e-07	0.81	0.00	1.00	FALSE
2	GTEx	Adipose Subcutaneous	NAGA	0.13	0.04	enet	10	0.03	9.0e-04	-5.2	-5.1	2.7e-07	-0.81	0.02	0.96	FALSE
27	GTEx	Skin Sun Exposed Lower leg	CYP2D6	0.38	0.45	lasso	9	0.46	5.8e-42	-5.4	5.1	2.9e-07	0.88	0.02	0.98	FALSE
50	The Cancer Genome Atlas	Soft Tissue Sarcoma	CYP2D6	0.11	0.09	blup	2	0.10	1.4e-06	-5.2	5.1	2.9e-07	0.81	0.00	1.00	FALSE