Best TWAS P=1.86e-11 · Best GWAS P=2.1e-09 conditioned to 0.00064
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | MGAT3 | 0.04 | 0.00 | blup | 392 | 0.00 | 1.9e-01 | -5.7 | 5.6 | 2.7e-08 | -0.68 | 0.03 | 0.73 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | MGAT3 | 0.08 | 0.04 | lasso | 4 | 0.04 | 4.3e-04 | -5.7 | 5.7 | 1.1e-08 | -0.93 | 0.02 | 0.97 | FALSE |
| 3 | GTEx | Breast Mammary Tissue | MGAT3 | 0.15 | 0.01 | lasso | 4 | 0.00 | 2.3e-01 | -5.2 | 5.2 | 2.0e-07 | -0.83 | 0.04 | 0.52 | FALSE |
| 4 | GTEx | Esophagus Muscularis | MGAT3 | 0.09 | 0.02 | enet | 15 | 0.02 | 1.3e-02 | -5.4 | 6.7 | 1.9e-11 | -0.43 | 0.07 | 0.67 | TRUE |
| 5 | GTEx | Heart Atrial Appendage | MGAT3 | 0.14 | 0.14 | lasso | 2 | 0.12 | 3.5e-06 | -5.6 | 5.7 | 1.2e-08 | -0.93 | 0.02 | 0.97 | FALSE |
| 6 | GTEx | Nerve Tibial | TAB1 | 0.15 | 0.13 | lasso | 5 | 0.15 | 1.0e-10 | -5.2 | -5.1 | 3.1e-07 | 0.81 | 0.24 | 0.76 | FALSE |
| 7 | GTEx | Skin Sun Exposed Lower leg | MGAT3 | 0.13 | 0.05 | lasso | 3 | 0.02 | 4.7e-03 | -5.6 | 5.6 | 2.2e-08 | -0.93 | 0.02 | 0.96 | FALSE |
| 8 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MGAT3 | 0.04 | 0.01 | blup | 48 | 0.04 | 2.3e-05 | -5.0 | 6.6 | 3.0e-11 | -0.59 | 0.17 | 0.64 | FALSE |