Best TWAS P=2.01e-14 · Best GWAS P=8.98e-20 conditioned to 1.02e-08
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | CommonMind | Brain Pre-frontal Cortex | FBXO38 | 0.05 | 0.01 | blup | 489 | 0.02 | 1.5e-03 | -7.2 | 6.5 | 9.5e-11 | 0.04 | 0.79 | 0.01 | FALSE |
2 | CommonMind | Brain Pre-frontal Cortex | HTR4 | 0.06 | 0.03 | lasso | 4 | 0.03 | 4.3e-05 | -5.6 | -6.9 | 4.1e-12 | -0.02 | 0.66 | 0.01 | FALSE |
3 | ROSMAP | Brain Pre-frontal Cortex | SPINK9 | 0.08 | 0.07 | enet | 21 | 0.07 | 1.4e-09 | -6.2 | -6.0 | 2.3e-09 | -0.03 | 1.00 | 0.00 | FALSE |
4 | YFS | Blood | ADRB2 | 0.09 | 0.05 | bslmm | 455 | 0.05 | 2.4e-15 | 8.7 | 6.4 | 1.4e-10 | 0.83 | 0.03 | 0.97 | FALSE |
5 | The Cancer Genome Atlas | Cervical Squamous Cell Carcinoma | FBXO38 | 0.04 | 0.04 | blup | 52 | 0.04 | 4.8e-03 | -6.8 | 7.0 | 1.8e-12 | 0.05 | 0.02 | 0.68 | FALSE |
6 | The Cancer Genome Atlas | Colon Adenocarcinoma | ADRB2 | 0.08 | 0.00 | blup | 55 | 0.01 | 7.7e-02 | -4.2 | -7.2 | 7.2e-13 | -0.59 | 0.01 | 0.48 | TRUE |
7 | The Cancer Genome Atlas | Colon Adenocarcinoma | FBXO38 | 0.05 | 0.02 | lasso | 2 | 0.02 | 4.3e-02 | -6.1 | 6.3 | 2.3e-10 | 0.03 | 0.04 | 0.31 | FALSE |
8 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | FBXO38 | 0.02 | 0.03 | enet | 2 | 0.03 | 1.9e-04 | 4.2 | 5.6 | 2.2e-08 | 0.04 | 0.04 | 0.56 | FALSE |
9 | The Cancer Genome Atlas | Brain Lower Grade Glioma | FBXO38 | 0.11 | 0.02 | blup | 52 | 0.04 | 8.2e-06 | -7.1 | 5.9 | 2.8e-09 | 0.06 | 0.02 | 0.98 | FALSE |
10 | The Cancer Genome Atlas | Lung Adenocarcinoma | FBXO38 | 0.03 | 0.02 | blup | 51 | 0.02 | 7.7e-04 | -6.2 | 7.0 | 2.2e-12 | 0.03 | 0.10 | 0.82 | FALSE |
11 | The Cancer Genome Atlas | Prostate Adenocarcinoma | FBXO38 | 0.05 | 0.01 | blup | 51 | 0.02 | 7.9e-03 | 3.3 | 7.7 | 2.0e-14 | 0.03 | 0.03 | 0.48 | TRUE |
12 | The Cancer Genome Atlas | Rectum Adenocarcinoma | FBXO38 | 0.13 | 0.17 | enet | 16 | 0.15 | 2.3e-04 | -7.2 | 7.2 | 4.5e-13 | 0.05 | 0.02 | 0.91 | FALSE |
13 | The Cancer Genome Atlas | Thyroid Carcinoma | FBXO38 | 0.06 | 0.01 | enet | 7 | 0.01 | 3.2e-02 | 1.4 | 6.0 | 1.7e-09 | 0.04 | 0.03 | 0.43 | FALSE |