Hub : Genes

ADRB2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 YFS Blood 0.0861 0.0193 3.8e-09 0.045 0.038 0.040 0.048 0.044 1.1e-14 2.3e-12 3.2e-13 2.4e-15 3.0e-14
2 TCGA Colon Adenocarcinoma 0.0790 0.0430 9.2e-03 -0.003 0.010 0.001 NA -0.005 5.7e-01 7.7e-02 2.9e-01 NA 8.3e-01
3 TCGA Lung Adenocarcinoma 0.0772 0.0271 2.3e-06 0.054 0.038 0.039 NA 0.044 5.8e-07 2.7e-05 2.2e-05 NA 5.9e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.0 0.0 0.1 0.0 0.2 -0.3
Bipolar Disorder or Schizophrenia 0.2 0.4 0.8 0.9 0.6 0.0
Depressed Affect (Nagel 2018) 0.1 0.2 0.2 0.4 0.5 -0.2
Depression (Nagel 2018) 0.6 0.8 1.9 1.4 -0.1 -0.8
Intelligence (Savage-Jansen 2018) 1.0 3.2 6.0 1.4 -2.5 -1.2
Neuroticism (Nagel 2018) 0.2 0.4 1.1 0.1 0.2 -1.0
Schizophrenia (2018) 0.3 0.6 1.3 1.2 0.7 0.2
Schizophrenia vs Biploar Disorder 0.3 0.4 0.7 -0.6 0.9 0.4
Worry (Nagel 2018) 0.4 0.8 2.2 0.5 -0.3 -1.5
Alzheimer’s Disease (in mother) 1.3 1.5 3.1 1.8 -0.8 -0.9
Alzheimer’s Disease (in father) 0.1 0.1 0.2 0.1 -0.5 -0.0
Alzheimer’s Disease (including proxy) 0.5 0.7 1.2 1.1 -0.7 -0.6
Crohns Disease (2017) 1.0 2.1 5.1 2.3 -0.7 0.8
Irritable Bowel Disease (IBD) 0.9 2.1 4.1 2.0 -1.5 0.2
Ulcerative Colitis (UC) 0.5 0.8 1.3 1.1 -1.1 -0.2
Major Depression (MDD) 0.2 0.2 0.4 0.4 0.0 -0.6
Reaction Time 0.9 1.6 2.7 -0.9 1.7 1.1
Verbal and Numeric Reasoning (VNR) 1.9 4.6 8.2 2.9 -2.0 -1.2
Breast Cancer 0.3 0.6 0.9 0.8 0.9 0.6
Ovarian Cancer 0.3 0.4 0.8 0.6 -0.3 0.9
Prostate Cancer 1.1 1.5 3.7 1.9 -0.9 -0.3
Age at First Birth 0.4 0.6 1.5 -1.2 -0.5 -0.1
Bipolar Disorder (2011) 0.3 0.3 0.7 0.3 0.9 -0.4
Body Mass Index (BMI) (2010) 0.3 0.5 1.3 1.1 -0.2 -0.1
Coronary Artery Disease (CAD) 1.6 1.9 2.3 -1.3 1.3 1.5
Crohns Disease (2012) 0.4 0.6 1.4 -0.2 0.6 1.2
Mean Putamen Volume 1.4 1.6 2.2 -1.3 1.5 1.0
Fasting Glucose 0.3 0.3 0.7 0.5 -0.8 0.1
HbA1C 0.1 0.1 0.2 -0.4 0.2 -0.5
HDL Cholesterol 0.8 1.3 2.2 0.4 -1.3 -1.5
LDL Cholesterol 0.3 0.5 1.2 1.1 -0.4 0.0
Lupus 0.2 0.4 1.0 -1.0 -0.1 -0.4
Neuroticism (2016) 0.4 0.6 1.5 0.5 -1.2 -0.4
Primary Biliary Cirrhosis 1.7 2.5 5.0 -1.0 2.2 1.2
Rheumatoid Arthritis 0.1 0.1 0.3 -0.0 -0.6 -0.1
Schizophrenia (2014) 0.0 0.1 0.2 0.4 0.4 -0.1
Triglycerides 1.0 1.7 2.7 -0.9 1.2 1.7
Type 2 Diabetes (T2D) (2012) 0.6 0.7 1.3 -1.1 0.9 0.5
Ulcerative Colitis 0.4 0.6 1.2 -0.1 -1.1 -0.8
Blood Eosinophil Count 19.1 147.4 269.0 -16.4 11.4 6.6
Blood Platelet Count 0.2 2.1 3.1 -1.8 1.6 0.8
Blood Red Count 0.2 1.6 4.2 -2.1 0.6 0.2
Blood White Count 5.0 37.0 51.6 6.4 -7.2 -4.3
Heel T-Score 0.1 1.0 1.8 -1.0 1.4 0.5
BMI 0.0 0.1 0.2 0.2 0.4 0.5
Height 0.2 3.4 6.8 -0.4 -2.6 -1.8
Waist Hip Ratio (WHR) 0.7 3.1 9.0 -3.0 0.5 -0.1
Systolic Blood Pressure 4.9 24.5 57.2 -7.6 3.7 1.7
Smoking Status 1.4 3.3 4.5 -2.1 2.0 1.2
Allergy or Eczema 0.1 0.4 0.6 0.8 0.3 0.6
Cardiovascular Disease 3.1 10.4 22.4 -4.7 2.7 1.3
Hypothyroidism (self reported) 0.1 0.2 0.2 -0.3 0.4 -0.4
Respiratory disease 0.4 1.0 1.8 1.3 -0.7 -0.8
Type 2 Diabetes (T2D) (2018) 0.1 0.2 0.4 -0.6 0.2 0.4
Lung FEV1/FVC ratio 1.2 6.1 10.9 3.3 2.0 1.8
Lung FVC 1.3 6.8 10.4 0.6 3.1 3.2
Neuroticism 0.3 0.7 1.5 0.7 -0.4 -1.2
Chronotype (morning person) 0.3 0.8 1.1 1.1 -0.2 1.1
Hair Pigment 0.0 0.8 1.3 1.1 -0.8 0.7
Tanning 0.0 0.3 0.6 0.4 -0.8 -0.0
Hand grip strength (left) 1.3 3.4 5.7 1.2 -1.7 -2.4
Number of treatments/medications taken 0.0 0.0 0.0 -0.2 -0.2 -0.2
Average weekly spirits intake 0.7 0.9 1.6 1.3 -0.5 -1.0
Sensitivity / hurt feelings 0.1 0.2 0.4 0.3 0.7 0.4
Frequency of depressed mood in last 2 weeks 0.5 0.7 1.4 -0.0 1.2 0.8
Hearing difficulty/problems: Yes 0.7 1.1 1.9 -1.4 1.1 -0.2
Relative age of first facial hair 0.1 0.3 0.6 -0.8 -0.5 -0.1
Other serious medical condition/disability diagnosed by doctor 0.2 0.3 0.5 0.2 -0.6 -0.7
Ever used hormone-replacement therapy (HRT) 0.7 0.9 1.4 -0.6 1.2 0.9
Ever had hysterectomy (womb removed) 0.5 0.6 1.7 -0.2 0.4 1.3
Systolic blood pressure, automated reading 2.9 8.5 20.8 -4.6 2.0 1.0
Eye problems/disorders: Diabetes related eye disease 0.2 0.2 0.2 0.5 0.4 -0.3
Angina 0.7 0.9 1.8 -1.3 0.9 -0.2
Medication for hormone replacement therapy 0.1 0.1 0.1 0.1 -0.3 0.3
Vitamin and mineral supplements 0.9 1.2 3.0 -1.7 0.7 0.4
Supplements: Zinc 0.2 0.2 0.4 0.6 -0.3 0.2
Medication: Co-codamol 0.8 1.0 1.4 -0.4 -1.2 -1.2
Medication: Metformin 1.3 1.9 3.3 -1.1 1.0 1.8
Diabetes (father) 0.2 0.3 0.6 0.8 -0.5 -0.2
Diabetes (mother) 0.2 0.2 0.5 0.3 0.0 -0.7
Severe depression (siblings) 0.1 0.1 0.3 -0.5 -0.4 -0.1
Pack years adult smoking proportion 0.1 0.2 0.4 -0.7 -0.4 -0.0
Impedance of leg (right) 0.6 2.8 7.3 -2.7 1.1 0.2
Leg fat-free mass (left) 0.2 1.1 1.9 1.1 -1.4 0.3
Trunk fat percentage 0.3 1.2 3.3 -1.8 -0.2 0.3
Hand grip strength (right) 0.2 0.5 1.3 -0.1 -0.6 -1.1
Townsend deprivation index at recruitment 0.2 0.3 0.9 -0.0 -0.1 -1.0
Current tobacco smoking 3.1 5.1 6.2 -2.5 2.3 2.0
Average weekly fortified wine intake 0.2 0.2 0.6 -0.1 0.2 0.8
Maternal smoking around birth 0.2 0.3 0.7 0.3 0.5 0.8
Fed-up feelings 0.1 0.2 0.3 -0.4 0.5 0.4
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.4 1.5 -0.4 -0.3
Relative age voice broke 2.2 3.3 6.0 0.7 -2.5 -1.9
Taking other prescription medications 0.0 0.0 0.1 -0.3 -0.1 -0.0
Age when periods started (menarche) 0.3 0.6 1.7 0.2 1.3 0.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.6 0.8 -0.9 0.6 0.9
Heel bone mineral density (BMD) T-score, automated (left) 1.3 3.0 3.3 -1.7 1.8 1.7
Tinnitus: Yes, but not now, but have in the past 1.4 1.5 2.0 -1.0 -1.2 -1.4
Qualifications: CSEs or equivalent 0.8 1.1 1.6 -0.3 1.3 1.3
Serious illness, injury or assault to yourself 0.6 0.7 1.8 0.7 -1.3 -0.1
High blood pressure 3.4 9.6 23.8 -4.9 2.2 0.5
Hayfever, allergic rhinitis or eczema 0.1 0.1 0.2 0.4 0.4 0.2
Multivitamins +/- minerals 0.2 0.3 0.8 0.9 -0.0 -0.3
Stomach or abdominal pain in last month 0.1 0.1 0.3 0.0 0.5 -0.4
Supplements: Glucosamine 1.6 2.1 4.9 2.2 -0.8 0.9
Diverticular disease/diverticulitis (self-reported) 0.1 0.2 0.3 -0.1 -0.4 -0.6
Medication: Atenolol 1.4 1.8 3.1 -1.8 1.5 0.2
Medication: Levothyroxine sodium 0.1 0.1 0.2 -0.3 0.3 -0.5
Sitting height 0.1 0.9 2.5 0.3 -1.6 0.1
Chronic bronchitis/emphysema (father) 0.2 0.3 0.6 0.4 -0.8 -0.3
High blood pressure (mother) 0.2 0.3 0.5 -0.7 0.7 -0.2
Body mass index (BMI) 0.0 0.2 0.4 -0.3 -0.1 0.6
Impedance of leg (left) 0.4 2.0 5.3 -2.3 0.9 -0.1
Leg predicted mass (left) 0.2 1.1 2.0 1.1 -1.4 0.3
Trunk fat mass 0.2 0.7 1.5 -1.2 -0.7 0.1
Waist circumference 0.2 0.8 1.1 -0.8 -1.0 -0.7
Number of incorrect matches in round 0.1 0.1 0.2 -0.2 0.2 -0.4
Past tobacco smoking 0.6 1.2 2.0 1.4 -1.2 -0.4
Alcohol usually taken with meals 0.8 1.2 1.8 1.3 -1.1 -0.8
Nervous feelings 0.9 1.6 2.2 1.5 -1.0 -1.3
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 1.7 1.3 -0.8 -1.1
Hearing difficulty/problems with background noise 0.2 0.3 0.6 0.5 -0.1 -0.8
Hair/balding pattern: Pattern 2 0.8 1.0 1.4 -1.2 0.8 1.0
Had menopause 0.3 0.4 0.8 0.3 0.5 0.9
Had other major operations 0.8 1.0 2.4 0.6 -1.5 -0.5
Forced vital capacity (FVC) 0.2 0.9 1.7 0.7 0.7 1.3
Heel bone mineral density (BMD) T-score, automated (right) 1.2 2.8 4.0 -1.8 2.0 0.9
Ever unenthusiastic/disinterested for a whole week 3.0 3.6 5.0 1.2 -2.2 -2.1
Qualifications: None of the above 0.2 0.4 0.8 -0.6 0.9 -0.4
Financial difficulties in last 2 years 1.3 1.8 2.4 1.5 -1.4 -1.0
Mouth/teeth dental problems 0.2 0.3 0.4 0.6 -0.6 -0.6
Heart attack 0.3 0.4 0.7 -0.8 -0.6 -0.5
Allergy 0.2 0.4 0.8 -0.9 -0.1 0.5
Pain all over the body in last month 0.9 0.9 1.5 -0.3 1.2 1.1
Diabetes (self-reported) 0.7 1.1 2.5 -1.6 0.9 0.1
Hayfever/allergic rhinitis (self-reported) 1.6 2.1 5.2 -0.3 1.1 2.3
Medication: Ramipril 0.9 1.2 2.1 -1.1 1.4 -0.6
Medication: Simvastatin 1.1 1.6 4.3 -2.1 -0.4 -0.6
Fluid intelligence score 1.3 2.6 2.8 1.6 -1.7 -1.6
Illnesses of siblings 0.1 0.1 0.2 0.2 -0.3 -0.4
Neuroticism score 0.1 0.2 0.4 -0.3 0.6 -0.3
Weight 0.1 0.4 0.8 -0.3 -0.9 0.4
Impedance of arm (right) 0.9 4.1 10.1 -3.2 1.4 0.4
Arm fat percentage (right) 0.3 1.4 4.0 -2.0 -0.1 0.4
Trunk fat-free mass 0.4 2.5 3.8 1.9 -1.9 -0.3
Hip circumference 0.2 0.7 2.0 0.2 -1.4 -0.2
Time employed in main current job 0.3 0.4 0.6 0.6 -0.5 -0.7
Alcohol intake versus 10 years previously 0.5 0.7 1.1 -0.4 -0.9 -1.1
Father’s age at death 0.4 0.5 0.8 0.1 0.8 0.9
Worrier / anxious feelings 0.1 0.1 0.2 0.5 -0.2 -0.2
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.1 0.3 -0.6 0.0 -0.2
Falls in the last year 0.6 0.8 2.2 -0.1 -0.3 -1.5
Hair/balding pattern: Pattern 3 0.7 1.1 2.2 1.5 -0.9 -0.3
Number of live births 0.1 0.1 0.2 -0.2 0.4 0.4
Forced expiratory volume in 1-second (FEV1) 0.6 2.2 4.1 2.0 0.7 1.4
Pulse rate 0.4 0.8 1.2 -0.7 -0.8 -1.1
Happiness 0.2 0.2 0.2 -0.4 -0.4 -0.5
Noisy workplace 0.3 0.3 0.5 -0.7 0.4 0.5
Qualifications: A levels/AS levels or equivalent 0.1 0.3 0.6 0.8 -0.3 0.3
Serious illness, injury or assault of a close relative in last 2 years 2.4 2.8 7.8 2.8 -0.6 -0.5
Mouth/teeth dental problems: Dentures 0.2 0.3 0.4 0.3 0.7 0.6
Asthma 0.3 0.6 1.1 1.0 0.0 -0.8
Medication: Ibuprofen (e.g. Nurofen) 1.4 1.8 2.3 1.0 -1.5 -1.5
Medication: Cholesterol lowering 1.5 2.4 3.9 -0.6 -2.0 -1.7
Depression (self-reported) 0.3 0.4 1.0 1.0 0.2 -0.3
Medication: Lansoprazole 0.1 0.1 0.2 -0.3 -0.4 0.1
Prospective memory result 1.9 2.3 5.1 -0.5 2.3 1.2
Lung cancer (father) 2.7 3.2 4.5 2.1 -1.9 -1.3
Illnesses of mother 0.2 0.2 0.4 0.6 -0.5 0.2
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.4 4.5 1.1 1.2 2.1
Pulse wave Arterial Stiffness index 0.0 0.0 0.0 -0.2 0.0 -0.2
Impedance of arm (left) 0.4 1.8 5.2 -2.3 0.5 0.0
Arm fat mass (right) 0.1 0.4 0.7 -0.9 -0.6 0.3
Trunk predicted mass 0.5 2.6 4.1 1.9 -2.0 -0.3
Standing height 0.1 1.4 3.7 0.3 -1.9 -0.6
Length of working week for main job 1.5 1.7 2.6 -1.6 1.3 0.8
Exposure to tobacco smoke at home 3.7 4.2 5.4 -2.3 1.5 2.2
Breastfed as a baby 0.6 0.7 1.1 -0.3 1.0 1.0
Tense / ‘highly strung’ 0.8 1.4 2.8 0.2 -1.1 -1.7
Seen doctor (GP) for nerves, anxiety, tension or depression 2.5 3.8 5.1 2.0 -2.3 -1.5
Hair/balding pattern: Pattern 4 0.5 1.1 2.3 -0.4 -1.0 -1.5
Birth weight of first child 0.2 0.3 0.5 0.7 0.0 -0.7
Peak expiratory flow (PEF) 1.2 2.7 5.6 2.4 0.2 1.6
Pulse wave reflection index 0.2 0.3 0.6 0.8 0.3 -0.2
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.4 0.2 -0.4 -1.2
Loud music exposure frequency 0.3 0.3 0.9 0.0 -0.4 -0.9
Qualifications: O levels/GCSEs or equivalent 0.9 1.4 2.9 1.1 -1.7 -0.4
Mouth/teeth dental problems: Bleeding gums 0.2 0.2 0.4 -0.6 0.5 -0.1
Blood clot in the leg (DVT) 0.2 0.3 0.5 -0.6 0.2 0.7
Medication: Paracetamol 1.9 3.1 6.3 2.5 -1.5 -1.0
Headache pain in last month 0.1 0.2 0.4 0.6 -0.3 -0.5
Medication for cholesterol, blood pressure or diabetes 0.7 1.2 3.0 1.7 -0.2 0.7
Glaucoma (self-reported) 4.3 5.0 7.8 2.8 -2.0 -1.9
Gout (self-reported) 0.3 0.4 1.1 1.0 -0.3 0.3
Hypothyroidism/myxoedema (self-reported) 0.0 0.1 0.2 0.2 0.4 0.3
Medication: Amlodipine 0.7 1.0 2.0 -0.7 -0.7 -1.4
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.6 -0.8 -0.3 -0.4
Birth weight 0.1 0.3 0.8 0.2 0.2 -0.9
Chronic bronchitis/emphysema (mother) 0.4 0.5 0.9 0.3 -1.0 -0.6
High blood pressure (siblings) 0.3 0.5 1.5 0.0 0.1 1.2
Forced vital capacity (FVC), Best measure 0.4 1.5 3.7 0.1 0.9 1.9
Body fat percentage 0.3 1.2 3.3 -1.8 -0.1 0.4
Leg fat percentage (right) 0.4 1.5 3.8 -1.9 0.5 0.8
Arm fat-free mass (right) 0.4 1.9 2.9 1.7 -1.7 0.0
Exposure to tobacco smoke outside home 0.6 0.8 2.2 0.0 -0.2 -1.5
Comparative body size at age 10 0.7 2.1 3.9 -1.3 2.0 0.8
Number of full brothers 2.0 2.5 4.6 -0.3 2.1 1.7
Worry too long after embarrassment 0.2 0.3 0.6 -0.8 0.1 -0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 3.4 4.4 5.4 2.2 -2.3 -1.6
Wheeze or whistling in the chest in last year 2.7 4.8 5.3 2.0 -2.3 -2.3
Number of children fathered 2.5 2.8 5.2 2.3 -1.5 -1.0
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.3 0.3 0.6 -0.1
Age at first live birth 0.7 1.2 1.7 0.7 -1.2 -1.3
Pulse wave peak to peak time 0.1 0.1 0.2 0.3 -0.4 -0.1
Health satisfaction 0.9 1.2 2.4 -0.2 -1.5 -1.0
Shortness of breath walking on level ground 3.0 3.6 5.8 0.2 -2.4 -2.2
Qualifications: College or University degree 0.1 0.3 0.6 -0.2 0.6 0.8
Eye problems/disorders: None of the above 0.7 0.8 2.0 -1.4 0.3 -0.6
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.2 0.9 -0.6 -1.1
Emphysema/chronic bronchitis 0.1 0.2 0.4 0.1 0.3 -0.6
Medication for pain relief, constipation, heartburn 0.7 1.2 2.2 -0.5 1.5 1.0
Neck or shoulder pain in last month 0.2 0.2 0.3 -0.6 -0.2 0.6
Medication: Blood pressure 0.9 1.6 3.4 -1.8 0.3 -1.1
Angina (self-reported) 0.7 0.9 1.9 -1.4 0.9 -0.1
Migraine (self-reported) 4.4 5.4 8.6 1.7 -2.9 -2.2
Medication: Ibuprofen 2.5 2.9 4.0 1.1 -2.0 -1.9
Medication: Allopurinol 0.5 0.6 1.4 1.2 -0.0 0.7
Medication: Omeprazole 1.0 1.3 2.2 0.8 -1.5 -1.0
Medication: Seretide 50 evohaler 0.1 0.2 0.3 -0.6 0.4 -0.1
Mean time to correctly identify matches 0.1 0.1 0.2 0.1 0.4 0.4
Heart disease (mother) 0.1 0.1 0.3 -0.1 -0.6 -0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.1 1.3 3.0 0.3 -1.0 -1.7
Whole body fat mass 0.1 0.6 1.5 -1.2 -0.5 0.3
Leg fat mass (right) 0.1 0.5 1.0 -1.0 -0.1 0.6
Arm predicted mass (right) 0.4 2.2 3.6 1.9 -1.7 0.2
Pulse rate, automated reading 0.1 0.5 1.3 -0.3 -1.1 -0.0
Alcohol intake frequency. 0.6 1.5 3.5 -0.6 -0.8 -1.9
Comparative height size at age 10 0.1 0.6 1.2 -0.2 -1.1 -0.6
Number of full sisters 0.6 0.8 1.1 -0.7 0.9 1.1
Suffer from ‘nerves’ 0.2 0.3 0.5 0.3 0.7 0.6
Overall health rating 0.4 0.8 1.3 -1.2 -0.5 -0.8
Chest pain or discomfort 0.1 0.1 0.2 -0.3 -0.3 -0.5
Had major operations 0.9 1.1 1.4 1.2 -0.9 -1.0
Age at last live birth 2.1 3.1 3.7 1.9 -1.9 -1.4
Family relationship satisfaction 0.7 0.8 1.0 0.9 -0.8 -1.0
Leg pain on walking 0.2 0.2 0.6 -0.1 -0.1 0.8
Qualifications: NVQ or HND or HNC or equivalent 0.5 0.6 1.8 1.3 -0.2 0.0
Commuting to job workplace: Car/motor vehicle 1.0 1.2 1.8 1.4 -1.3 -0.4
Illness, injury, bereavement, stress in last 2 years 0.1 0.1 0.2 -0.3 0.4 0.1
Medication: Aspirin 0.5 0.6 1.1 -1.0 0.8 0.4
Supplements: Vitamin C 0.5 0.6 0.9 1.0 -0.2 0.9
Knee pain experienced in last month 0.7 1.0 1.2 0.9 -1.1 -1.1
Hypertension (Self-reported) 4.3 12.0 29.3 -5.4 2.4 0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.1 1.3 3.8 -1.9 0.2 -0.5
Illnesses of father: Heart disease 0.2 0.2 0.4 -0.6 -0.3 -0.5
Illnesses of siblings: Diabetes 0.5 0.6 1.3 -1.2 0.7 0.2
Smoking status: Previous 0.2 0.4 0.7 -0.8 0.6 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 2.4 0.7 -1.5 -0.0
Whole body fat-free mass 0.3 1.9 3.0 1.6 -1.7 0.0
Leg fat-free mass (right) 0.3 1.4 2.0 1.4 -1.4 0.3
Arm fat percentage (left) 0.2 0.8 2.3 -1.5 -0.3 0.2
Average weekly red wine intake 0.0 0.0 0.1 0.3 0.2 -0.1
Handedness (chirality/laterality): Left-handed 0.1 0.1 0.2 -0.4 -0.3 0.2
Mood swings 0.4 0.8 1.9 0.5 -0.5 -1.4
Loneliness, isolation 0.3 0.4 1.0 0.3 0.4 1.0
Long-standing illness, disability or infirmity 0.1 0.1 0.2 -0.3 0.2 -0.5
Ever had bowel cancer screening 0.6 0.7 1.4 -1.2 0.3 -0.9
Diabetes diagnosed by doctor 0.1 0.1 0.3 -0.5 0.2 -0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.4 0.4 0.8 0.6 -0.9 0.3
Friendships satisfaction 0.0 0.0 0.1 0.0 0.3 0.0
Qualifications: nursing, teaching 0.3 0.5 1.3 -0.4 -1.1 0.3
Commuting to job workplace: Walk 0.1 0.2 0.4 -0.2 0.6 0.1
Eye problems/disorders: Cataract 3.2 3.7 6.3 2.5 -2.1 -0.4
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 3.3 -1.8 0.3 0.8
Medication for cholesterol 1.8 2.7 6.4 2.5 -0.9 -1.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.4 0.4 0.6 -0.5 -0.8 -0.7
Back pain experienced in last month 0.5 0.7 1.0 -0.8 1.0 -0.6
Mineral and other dietary supplements 0.6 0.9 2.5 -1.6 0.2 -0.0
Breast cancer (self-reported) 2.0 2.4 3.9 0.6 -1.7 -2.0
Asthma (self-reported) 0.2 0.5 0.9 0.6 0.2 -1.0
Osteoporosis (self-reported) 0.4 0.5 1.3 1.2 -0.4 -0.2
Osteoarthritis (self-reported) 0.1 0.1 0.2 0.4 0.4 0.2
Medication: Aspirin 0.4 0.6 1.4 -1.2 0.5 0.0
Medication: Gliclazide 0.8 0.9 1.5 1.2 -1.1 -0.3
Illnesses of father: None of the above (group 1) 0.5 0.7 0.8 0.9 0.8 0.7
Smoking status: Current 1.9 3.1 4.0 -2.0 1.9 1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 1.3 2.8 3.7 1.6 1.5 1.9
Whole body water mass 0.4 2.0 3.2 1.7 -1.8 -0.0
Leg predicted mass (right) 0.2 1.3 2.0 1.4 -1.3 0.4
Arm fat mass (left) 0.1 0.3 0.4 -0.7 -0.6 0.4
Number of self-reported non-cancer illnesses 0.3 0.4 0.7 0.6 -0.5 -0.8
Average weekly champagne plus white wine intake 0.3 0.4 0.6 0.8 0.3 -0.7
Miserableness 0.1 0.2 0.4 -0.6 0.5 0.1
Guilty feelings 0.3 0.4 0.6 -0.8 0.7 0.1
Wears glasses or contact lenses 0.9 1.1 1.8 0.1 -1.3 -1.2
Ever taken oral contraceptive pill 2.6 2.9 7.5 2.7 -1.0 0.4
Hearing aid user 1.1 1.2 2.4 0.8 -0.8 -1.5
Mother’s age at death 0.0 0.1 0.1 -0.2 0.3 0.1
Financial situation satisfaction 0.5 0.6 1.4 0.7 -1.2 -0.2
Tinnitus: Yes, now most or all of the time 0.8 1.0 1.4 1.1 -1.2 -0.6
Commuting to job workplace: Public transport 0.8 0.9 2.0 -0.8 1.4 0.4
Eye problems/disorders: Glaucoma 1.7 2.1 4.5 2.1 -1.3 -0.2
Medication: Blood pressure 3.6 6.9 17.0 -4.1 1.8 0.8
Pain type(s) experienced in last month: Hip pain 0.8 1.0 1.9 -0.7 -0.9 -1.4
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.1 1.1 0.1 -0.3
High cholesterol (Self-reported) 0.2 0.4 0.6 -0.8 -0.5 -0.6
Medication: Bendroflumethiazide 1.7 2.5 6.8 -2.6 0.2 -0.8
Medication: Paracetamol 1.8 2.8 6.0 2.4 -1.3 -0.9
Medication: Lisinopril 1.5 2.0 4.8 -2.2 1.1 0.1
Medication: Atorvastatin 0.3 0.3 0.5 0.1 0.7 0.7
Illnesses of father: High blood pressure 0.8 1.0 2.6 -1.6 0.6 0.3
Alcohol drinker status: Never 2.7 3.3 5.5 -2.0 -0.4 -2.4
Ever smoked 1.3 2.2 2.9 -1.4 1.7 1.3
Basal metabolic rate 0.3 1.5 2.6 1.4 -1.6 0.1
Leg fat percentage (left) 0.3 1.2 3.1 -1.8 0.3 0.6
Arm fat-free mass (left) 0.2 0.8 1.2 1.1 -1.1 0.3
Number of operations (self-reported) 0.4 0.5 1.0 0.7 -1.0 -0.4
Average weekly beer plus cider intake 0.1 0.1 0.2 0.5 0.2 -0.1
Irritability 0.9 1.5 3.6 0.0 -1.0 -1.9
Risk taking 0.9 1.3 2.3 -1.0 1.5 0.9
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.2 0.1 -0.2 -0.4
Fractured/broken bones in last 5 years 1.5 1.9 5.4 2.3 -0.4 0.2
Age started oral contraceptive pill 0.5 0.6 1.2 -1.1 -0.3 -0.6
Diastolic blood pressure, automated reading 2.1 6.6 14.8 -3.8 2.2 0.6
Ever depressed for a whole week 0.8 1.0 1.9 -0.9 -1.4 -0.5
Unable to work because of sickness or disability 0.1 0.1 0.2 0.0 0.2 -0.4
Commuting to job workplace: Cycle 1.0 1.2 1.9 1.0 -0.8 -1.4
Myopia 0.5 0.8 1.0 -0.8 0.8 1.0
Vascular/heart problems diagnosed by doctor 4.0 11.0 27.1 5.2 -2.4 -0.3
Cholesterol lowering medication 2.5 3.7 5.1 -2.2 1.9 1.5
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 3.6 0.7 -1.9 -1.2
Pain experienced in last month 0.1 0.2 0.4 0.7 0.0 0.5
Supplements: Calcium 3.1 3.4 4.3 2.1 -1.6 -1.9
Basal cell carcinoma (self-reported) 0.6 0.7 1.2 1.0 -0.2 -1.1
Heart attack/myocardial infarction (self-reported) 0.3 0.4 0.6 -0.7 -0.8 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.6 -0.8 0.3 0.6
Heart disease (siblings) 2.2 2.7 4.3 -1.8 2.1 0.7
Alcohol drinker status: Previous 3.5 4.0 6.4 0.9 -2.2 -2.5
Pack years of smoking 0.2 0.3 0.6 -0.5 -0.8 -0.5
Impedance of whole body 0.5 2.4 6.4 -2.5 0.9 0.2
Leg fat mass (left) 0.1 0.3 0.6 -0.8 -0.4 0.3
Arm predicted mass (left) 0.3 1.5 2.2 1.5 -1.5 0.0