Hub : Genes

ADRB2

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	YFS	Blood	0.0861	0.0193	3.8e-09	0.045	0.038	0.040	0.048	0.044	1.1e-14	2.3e-12	3.2e-13	2.4e-15	3.0e-14
2	TCGA	Colon Adenocarcinoma	0.0790	0.0430	9.2e-03	-0.003	0.010	0.001	NA	-0.005	5.7e-01	7.7e-02	2.9e-01	NA	8.3e-01
3	TCGA	Lung Adenocarcinoma	0.0772	0.0271	2.3e-06	0.054	0.038	0.039	NA	0.044	5.8e-07	2.7e-05	2.2e-05	NA	5.9e-06

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.0	0.0	0.1	0.0	0.2	-0.3
Bipolar Disorder or Schizophrenia	0.2	0.4	0.8	0.9	0.6	0.0
Depressed Affect (Nagel 2018)	0.1	0.2	0.2	0.4	0.5	-0.2
Depression (Nagel 2018)	0.6	0.8	1.9	1.4	-0.1	-0.8
Intelligence (Savage-Jansen 2018)	1.0	3.2	6.0	1.4	-2.5	-1.2
Neuroticism (Nagel 2018)	0.2	0.4	1.1	0.1	0.2	-1.0
Schizophrenia (2018)	0.3	0.6	1.3	1.2	0.7	0.2
Schizophrenia vs Biploar Disorder	0.3	0.4	0.7	-0.6	0.9	0.4
Worry (Nagel 2018)	0.4	0.8	2.2	0.5	-0.3	-1.5
Alzheimer’s Disease (in mother)	1.3	1.5	3.1	1.8	-0.8	-0.9
Alzheimer’s Disease (in father)	0.1	0.1	0.2	0.1	-0.5	-0.0
Alzheimer’s Disease (including proxy)	0.5	0.7	1.2	1.1	-0.7	-0.6
Crohns Disease (2017)	1.0	2.1	5.1	2.3	-0.7	0.8
Irritable Bowel Disease (IBD)	0.9	2.1	4.1	2.0	-1.5	0.2
Ulcerative Colitis (UC)	0.5	0.8	1.3	1.1	-1.1	-0.2
Major Depression (MDD)	0.2	0.2	0.4	0.4	0.0	-0.6
Reaction Time	0.9	1.6	2.7	-0.9	1.7	1.1
Verbal and Numeric Reasoning (VNR)	1.9	4.6	8.2	2.9	-2.0	-1.2
Breast Cancer	0.3	0.6	0.9	0.8	0.9	0.6
Ovarian Cancer	0.3	0.4	0.8	0.6	-0.3	0.9
Prostate Cancer	1.1	1.5	3.7	1.9	-0.9	-0.3
Age at First Birth	0.4	0.6	1.5	-1.2	-0.5	-0.1
Bipolar Disorder (2011)	0.3	0.3	0.7	0.3	0.9	-0.4
Body Mass Index (BMI) (2010)	0.3	0.5	1.3	1.1	-0.2	-0.1
Coronary Artery Disease (CAD)	1.6	1.9	2.3	-1.3	1.3	1.5
Crohns Disease (2012)	0.4	0.6	1.4	-0.2	0.6	1.2
Mean Putamen Volume	1.4	1.6	2.2	-1.3	1.5	1.0
Fasting Glucose	0.3	0.3	0.7	0.5	-0.8	0.1
HbA1C	0.1	0.1	0.2	-0.4	0.2	-0.5
HDL Cholesterol	0.8	1.3	2.2	0.4	-1.3	-1.5
LDL Cholesterol	0.3	0.5	1.2	1.1	-0.4	0.0
Lupus	0.2	0.4	1.0	-1.0	-0.1	-0.4
Neuroticism (2016)	0.4	0.6	1.5	0.5	-1.2	-0.4
Primary Biliary Cirrhosis	1.7	2.5	5.0	-1.0	2.2	1.2
Rheumatoid Arthritis	0.1	0.1	0.3	-0.0	-0.6	-0.1
Schizophrenia (2014)	0.0	0.1	0.2	0.4	0.4	-0.1
Triglycerides	1.0	1.7	2.7	-0.9	1.2	1.7
Type 2 Diabetes (T2D) (2012)	0.6	0.7	1.3	-1.1	0.9	0.5
Ulcerative Colitis	0.4	0.6	1.2	-0.1	-1.1	-0.8
Blood Eosinophil Count	19.1	147.4	269.0	-16.4	11.4	6.6
Blood Platelet Count	0.2	2.1	3.1	-1.8	1.6	0.8
Blood Red Count	0.2	1.6	4.2	-2.1	0.6	0.2
Blood White Count	5.0	37.0	51.6	6.4	-7.2	-4.3
Heel T-Score	0.1	1.0	1.8	-1.0	1.4	0.5
BMI	0.0	0.1	0.2	0.2	0.4	0.5
Height	0.2	3.4	6.8	-0.4	-2.6	-1.8
Waist Hip Ratio (WHR)	0.7	3.1	9.0	-3.0	0.5	-0.1
Systolic Blood Pressure	4.9	24.5	57.2	-7.6	3.7	1.7
Smoking Status	1.4	3.3	4.5	-2.1	2.0	1.2
Allergy or Eczema	0.1	0.4	0.6	0.8	0.3	0.6
Cardiovascular Disease	3.1	10.4	22.4	-4.7	2.7	1.3
Hypothyroidism (self reported)	0.1	0.2	0.2	-0.3	0.4	-0.4
Respiratory disease	0.4	1.0	1.8	1.3	-0.7	-0.8
Type 2 Diabetes (T2D) (2018)	0.1	0.2	0.4	-0.6	0.2	0.4
Lung FEV1/FVC ratio	1.2	6.1	10.9	3.3	2.0	1.8
Lung FVC	1.3	6.8	10.4	0.6	3.1	3.2
Neuroticism	0.3	0.7	1.5	0.7	-0.4	-1.2
Chronotype (morning person)	0.3	0.8	1.1	1.1	-0.2	1.1
Hair Pigment	0.0	0.8	1.3	1.1	-0.8	0.7
Tanning	0.0	0.3	0.6	0.4	-0.8	-0.0
Hand grip strength (left)	1.3	3.4	5.7	1.2	-1.7	-2.4
Number of treatments/medications taken	0.0	0.0	0.0	-0.2	-0.2	-0.2
Average weekly spirits intake	0.7	0.9	1.6	1.3	-0.5	-1.0
Sensitivity / hurt feelings	0.1	0.2	0.4	0.3	0.7	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	1.4	-0.0	1.2	0.8
Hearing difficulty/problems: Yes	0.7	1.1	1.9	-1.4	1.1	-0.2
Relative age of first facial hair	0.1	0.3	0.6	-0.8	-0.5	-0.1
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.5	0.2	-0.6	-0.7
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.4	-0.6	1.2	0.9
Ever had hysterectomy (womb removed)	0.5	0.6	1.7	-0.2	0.4	1.3
Systolic blood pressure, automated reading	2.9	8.5	20.8	-4.6	2.0	1.0
Eye problems/disorders: Diabetes related eye disease	0.2	0.2	0.2	0.5	0.4	-0.3
Angina	0.7	0.9	1.8	-1.3	0.9	-0.2
Medication for hormone replacement therapy	0.1	0.1	0.1	0.1	-0.3	0.3
Vitamin and mineral supplements	0.9	1.2	3.0	-1.7	0.7	0.4
Supplements: Zinc	0.2	0.2	0.4	0.6	-0.3	0.2
Medication: Co-codamol	0.8	1.0	1.4	-0.4	-1.2	-1.2
Medication: Metformin	1.3	1.9	3.3	-1.1	1.0	1.8
Diabetes (father)	0.2	0.3	0.6	0.8	-0.5	-0.2
Diabetes (mother)	0.2	0.2	0.5	0.3	0.0	-0.7
Severe depression (siblings)	0.1	0.1	0.3	-0.5	-0.4	-0.1
Pack years adult smoking proportion	0.1	0.2	0.4	-0.7	-0.4	-0.0
Impedance of leg (right)	0.6	2.8	7.3	-2.7	1.1	0.2
Leg fat-free mass (left)	0.2	1.1	1.9	1.1	-1.4	0.3
Trunk fat percentage	0.3	1.2	3.3	-1.8	-0.2	0.3
Hand grip strength (right)	0.2	0.5	1.3	-0.1	-0.6	-1.1
Townsend deprivation index at recruitment	0.2	0.3	0.9	-0.0	-0.1	-1.0
Current tobacco smoking	3.1	5.1	6.2	-2.5	2.3	2.0
Average weekly fortified wine intake	0.2	0.2	0.6	-0.1	0.2	0.8
Maternal smoking around birth	0.2	0.3	0.7	0.3	0.5	0.8
Fed-up feelings	0.1	0.2	0.3	-0.4	0.5	0.4
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.4	1.5	-0.4	-0.3
Relative age voice broke	2.2	3.3	6.0	0.7	-2.5	-1.9
Taking other prescription medications	0.0	0.0	0.1	-0.3	-0.1	-0.0
Age when periods started (menarche)	0.3	0.6	1.7	0.2	1.3	0.4
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	0.8	-0.9	0.6	0.9
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	3.3	-1.7	1.8	1.7
Tinnitus: Yes, but not now, but have in the past	1.4	1.5	2.0	-1.0	-1.2	-1.4
Qualifications: CSEs or equivalent	0.8	1.1	1.6	-0.3	1.3	1.3
Serious illness, injury or assault to yourself	0.6	0.7	1.8	0.7	-1.3	-0.1
High blood pressure	3.4	9.6	23.8	-4.9	2.2	0.5
Hayfever, allergic rhinitis or eczema	0.1	0.1	0.2	0.4	0.4	0.2
Multivitamins +/- minerals	0.2	0.3	0.8	0.9	-0.0	-0.3
Stomach or abdominal pain in last month	0.1	0.1	0.3	0.0	0.5	-0.4
Supplements: Glucosamine	1.6	2.1	4.9	2.2	-0.8	0.9
Diverticular disease/diverticulitis (self-reported)	0.1	0.2	0.3	-0.1	-0.4	-0.6
Medication: Atenolol	1.4	1.8	3.1	-1.8	1.5	0.2
Medication: Levothyroxine sodium	0.1	0.1	0.2	-0.3	0.3	-0.5
Sitting height	0.1	0.9	2.5	0.3	-1.6	0.1
Chronic bronchitis/emphysema (father)	0.2	0.3	0.6	0.4	-0.8	-0.3
High blood pressure (mother)	0.2	0.3	0.5	-0.7	0.7	-0.2
Body mass index (BMI)	0.0	0.2	0.4	-0.3	-0.1	0.6
Impedance of leg (left)	0.4	2.0	5.3	-2.3	0.9	-0.1
Leg predicted mass (left)	0.2	1.1	2.0	1.1	-1.4	0.3
Trunk fat mass	0.2	0.7	1.5	-1.2	-0.7	0.1
Waist circumference	0.2	0.8	1.1	-0.8	-1.0	-0.7
Number of incorrect matches in round	0.1	0.1	0.2	-0.2	0.2	-0.4
Past tobacco smoking	0.6	1.2	2.0	1.4	-1.2	-0.4
Alcohol usually taken with meals	0.8	1.2	1.8	1.3	-1.1	-0.8
Nervous feelings	0.9	1.6	2.2	1.5	-1.0	-1.3
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	1.7	1.3	-0.8	-1.1
Hearing difficulty/problems with background noise	0.2	0.3	0.6	0.5	-0.1	-0.8
Hair/balding pattern: Pattern 2	0.8	1.0	1.4	-1.2	0.8	1.0
Had menopause	0.3	0.4	0.8	0.3	0.5	0.9
Had other major operations	0.8	1.0	2.4	0.6	-1.5	-0.5
Forced vital capacity (FVC)	0.2	0.9	1.7	0.7	0.7	1.3
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.8	4.0	-1.8	2.0	0.9
Ever unenthusiastic/disinterested for a whole week	3.0	3.6	5.0	1.2	-2.2	-2.1
Qualifications: None of the above	0.2	0.4	0.8	-0.6	0.9	-0.4
Financial difficulties in last 2 years	1.3	1.8	2.4	1.5	-1.4	-1.0
Mouth/teeth dental problems	0.2	0.3	0.4	0.6	-0.6	-0.6
Heart attack	0.3	0.4	0.7	-0.8	-0.6	-0.5
Allergy	0.2	0.4	0.8	-0.9	-0.1	0.5
Pain all over the body in last month	0.9	0.9	1.5	-0.3	1.2	1.1
Diabetes (self-reported)	0.7	1.1	2.5	-1.6	0.9	0.1
Hayfever/allergic rhinitis (self-reported)	1.6	2.1	5.2	-0.3	1.1	2.3
Medication: Ramipril	0.9	1.2	2.1	-1.1	1.4	-0.6
Medication: Simvastatin	1.1	1.6	4.3	-2.1	-0.4	-0.6
Fluid intelligence score	1.3	2.6	2.8	1.6	-1.7	-1.6
Illnesses of siblings	0.1	0.1	0.2	0.2	-0.3	-0.4
Neuroticism score	0.1	0.2	0.4	-0.3	0.6	-0.3
Weight	0.1	0.4	0.8	-0.3	-0.9	0.4
Impedance of arm (right)	0.9	4.1	10.1	-3.2	1.4	0.4
Arm fat percentage (right)	0.3	1.4	4.0	-2.0	-0.1	0.4
Trunk fat-free mass	0.4	2.5	3.8	1.9	-1.9	-0.3
Hip circumference	0.2	0.7	2.0	0.2	-1.4	-0.2
Time employed in main current job	0.3	0.4	0.6	0.6	-0.5	-0.7
Alcohol intake versus 10 years previously	0.5	0.7	1.1	-0.4	-0.9	-1.1
Father’s age at death	0.4	0.5	0.8	0.1	0.8	0.9
Worrier / anxious feelings	0.1	0.1	0.2	0.5	-0.2	-0.2
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.1	0.3	-0.6	0.0	-0.2
Falls in the last year	0.6	0.8	2.2	-0.1	-0.3	-1.5
Hair/balding pattern: Pattern 3	0.7	1.1	2.2	1.5	-0.9	-0.3
Number of live births	0.1	0.1	0.2	-0.2	0.4	0.4
Forced expiratory volume in 1-second (FEV1)	0.6	2.2	4.1	2.0	0.7	1.4
Pulse rate	0.4	0.8	1.2	-0.7	-0.8	-1.1
Happiness	0.2	0.2	0.2	-0.4	-0.4	-0.5
Noisy workplace	0.3	0.3	0.5	-0.7	0.4	0.5
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.6	0.8	-0.3	0.3
Serious illness, injury or assault of a close relative in last 2 years	2.4	2.8	7.8	2.8	-0.6	-0.5
Mouth/teeth dental problems: Dentures	0.2	0.3	0.4	0.3	0.7	0.6
Asthma	0.3	0.6	1.1	1.0	0.0	-0.8
Medication: Ibuprofen (e.g. Nurofen)	1.4	1.8	2.3	1.0	-1.5	-1.5
Medication: Cholesterol lowering	1.5	2.4	3.9	-0.6	-2.0	-1.7
Depression (self-reported)	0.3	0.4	1.0	1.0	0.2	-0.3
Medication: Lansoprazole	0.1	0.1	0.2	-0.3	-0.4	0.1
Prospective memory result	1.9	2.3	5.1	-0.5	2.3	1.2
Lung cancer (father)	2.7	3.2	4.5	2.1	-1.9	-1.3
Illnesses of mother	0.2	0.2	0.4	0.6	-0.5	0.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.4	4.5	1.1	1.2	2.1
Pulse wave Arterial Stiffness index	0.0	0.0	0.0	-0.2	0.0	-0.2
Impedance of arm (left)	0.4	1.8	5.2	-2.3	0.5	0.0
Arm fat mass (right)	0.1	0.4	0.7	-0.9	-0.6	0.3
Trunk predicted mass	0.5	2.6	4.1	1.9	-2.0	-0.3
Standing height	0.1	1.4	3.7	0.3	-1.9	-0.6
Length of working week for main job	1.5	1.7	2.6	-1.6	1.3	0.8
Exposure to tobacco smoke at home	3.7	4.2	5.4	-2.3	1.5	2.2
Breastfed as a baby	0.6	0.7	1.1	-0.3	1.0	1.0
Tense / ‘highly strung’	0.8	1.4	2.8	0.2	-1.1	-1.7
Seen doctor (GP) for nerves, anxiety, tension or depression	2.5	3.8	5.1	2.0	-2.3	-1.5
Hair/balding pattern: Pattern 4	0.5	1.1	2.3	-0.4	-1.0	-1.5
Birth weight of first child	0.2	0.3	0.5	0.7	0.0	-0.7
Peak expiratory flow (PEF)	1.2	2.7	5.6	2.4	0.2	1.6
Pulse wave reflection index	0.2	0.3	0.6	0.8	0.3	-0.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.4	0.2	-0.4	-1.2
Loud music exposure frequency	0.3	0.3	0.9	0.0	-0.4	-0.9
Qualifications: O levels/GCSEs or equivalent	0.9	1.4	2.9	1.1	-1.7	-0.4
Mouth/teeth dental problems: Bleeding gums	0.2	0.2	0.4	-0.6	0.5	-0.1
Blood clot in the leg (DVT)	0.2	0.3	0.5	-0.6	0.2	0.7
Medication: Paracetamol	1.9	3.1	6.3	2.5	-1.5	-1.0
Headache pain in last month	0.1	0.2	0.4	0.6	-0.3	-0.5
Medication for cholesterol, blood pressure or diabetes	0.7	1.2	3.0	1.7	-0.2	0.7
Glaucoma (self-reported)	4.3	5.0	7.8	2.8	-2.0	-1.9
Gout (self-reported)	0.3	0.4	1.1	1.0	-0.3	0.3
Hypothyroidism/myxoedema (self-reported)	0.0	0.1	0.2	0.2	0.4	0.3
Medication: Amlodipine	0.7	1.0	2.0	-0.7	-0.7	-1.4
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	-0.8	-0.3	-0.4
Birth weight	0.1	0.3	0.8	0.2	0.2	-0.9
Chronic bronchitis/emphysema (mother)	0.4	0.5	0.9	0.3	-1.0	-0.6
High blood pressure (siblings)	0.3	0.5	1.5	0.0	0.1	1.2
Forced vital capacity (FVC), Best measure	0.4	1.5	3.7	0.1	0.9	1.9
Body fat percentage	0.3	1.2	3.3	-1.8	-0.1	0.4
Leg fat percentage (right)	0.4	1.5	3.8	-1.9	0.5	0.8
Arm fat-free mass (right)	0.4	1.9	2.9	1.7	-1.7	0.0
Exposure to tobacco smoke outside home	0.6	0.8	2.2	0.0	-0.2	-1.5
Comparative body size at age 10	0.7	2.1	3.9	-1.3	2.0	0.8
Number of full brothers	2.0	2.5	4.6	-0.3	2.1	1.7
Worry too long after embarrassment	0.2	0.3	0.6	-0.8	0.1	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	3.4	4.4	5.4	2.2	-2.3	-1.6
Wheeze or whistling in the chest in last year	2.7	4.8	5.3	2.0	-2.3	-2.3
Number of children fathered	2.5	2.8	5.2	2.3	-1.5	-1.0
Reason for reducing amount of alcohol drunk: Health precaution	0.1	0.1	0.3	0.3	0.6	-0.1
Age at first live birth	0.7	1.2	1.7	0.7	-1.2	-1.3
Pulse wave peak to peak time	0.1	0.1	0.2	0.3	-0.4	-0.1
Health satisfaction	0.9	1.2	2.4	-0.2	-1.5	-1.0
Shortness of breath walking on level ground	3.0	3.6	5.8	0.2	-2.4	-2.2
Qualifications: College or University degree	0.1	0.3	0.6	-0.2	0.6	0.8
Eye problems/disorders: None of the above	0.7	0.8	2.0	-1.4	0.3	-0.6
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.2	0.9	-0.6	-1.1
Emphysema/chronic bronchitis	0.1	0.2	0.4	0.1	0.3	-0.6
Medication for pain relief, constipation, heartburn	0.7	1.2	2.2	-0.5	1.5	1.0
Neck or shoulder pain in last month	0.2	0.2	0.3	-0.6	-0.2	0.6
Medication: Blood pressure	0.9	1.6	3.4	-1.8	0.3	-1.1
Angina (self-reported)	0.7	0.9	1.9	-1.4	0.9	-0.1
Migraine (self-reported)	4.4	5.4	8.6	1.7	-2.9	-2.2
Medication: Ibuprofen	2.5	2.9	4.0	1.1	-2.0	-1.9
Medication: Allopurinol	0.5	0.6	1.4	1.2	-0.0	0.7
Medication: Omeprazole	1.0	1.3	2.2	0.8	-1.5	-1.0
Medication: Seretide 50 evohaler	0.1	0.2	0.3	-0.6	0.4	-0.1
Mean time to correctly identify matches	0.1	0.1	0.2	0.1	0.4	0.4
Heart disease (mother)	0.1	0.1	0.3	-0.1	-0.6	-0.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.1	1.3	3.0	0.3	-1.0	-1.7
Whole body fat mass	0.1	0.6	1.5	-1.2	-0.5	0.3
Leg fat mass (right)	0.1	0.5	1.0	-1.0	-0.1	0.6
Arm predicted mass (right)	0.4	2.2	3.6	1.9	-1.7	0.2
Pulse rate, automated reading	0.1	0.5	1.3	-0.3	-1.1	-0.0
Alcohol intake frequency.	0.6	1.5	3.5	-0.6	-0.8	-1.9
Comparative height size at age 10	0.1	0.6	1.2	-0.2	-1.1	-0.6
Number of full sisters	0.6	0.8	1.1	-0.7	0.9	1.1
Suffer from ‘nerves’	0.2	0.3	0.5	0.3	0.7	0.6
Overall health rating	0.4	0.8	1.3	-1.2	-0.5	-0.8
Chest pain or discomfort	0.1	0.1	0.2	-0.3	-0.3	-0.5
Had major operations	0.9	1.1	1.4	1.2	-0.9	-1.0
Age at last live birth	2.1	3.1	3.7	1.9	-1.9	-1.4
Family relationship satisfaction	0.7	0.8	1.0	0.9	-0.8	-1.0
Leg pain on walking	0.2	0.2	0.6	-0.1	-0.1	0.8
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.8	1.3	-0.2	0.0
Commuting to job workplace: Car/motor vehicle	1.0	1.2	1.8	1.4	-1.3	-0.4
Illness, injury, bereavement, stress in last 2 years	0.1	0.1	0.2	-0.3	0.4	0.1
Medication: Aspirin	0.5	0.6	1.1	-1.0	0.8	0.4
Supplements: Vitamin C	0.5	0.6	0.9	1.0	-0.2	0.9
Knee pain experienced in last month	0.7	1.0	1.2	0.9	-1.1	-1.1
Hypertension (Self-reported)	4.3	12.0	29.3	-5.4	2.4	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.1	1.3	3.8	-1.9	0.2	-0.5
Illnesses of father: Heart disease	0.2	0.2	0.4	-0.6	-0.3	-0.5
Illnesses of siblings: Diabetes	0.5	0.6	1.3	-1.2	0.7	0.2
Smoking status: Previous	0.2	0.4	0.7	-0.8	0.6	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	2.4	0.7	-1.5	-0.0
Whole body fat-free mass	0.3	1.9	3.0	1.6	-1.7	0.0
Leg fat-free mass (right)	0.3	1.4	2.0	1.4	-1.4	0.3
Arm fat percentage (left)	0.2	0.8	2.3	-1.5	-0.3	0.2
Average weekly red wine intake	0.0	0.0	0.1	0.3	0.2	-0.1
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.2	-0.4	-0.3	0.2
Mood swings	0.4	0.8	1.9	0.5	-0.5	-1.4
Loneliness, isolation	0.3	0.4	1.0	0.3	0.4	1.0
Long-standing illness, disability or infirmity	0.1	0.1	0.2	-0.3	0.2	-0.5
Ever had bowel cancer screening	0.6	0.7	1.4	-1.2	0.3	-0.9
Diabetes diagnosed by doctor	0.1	0.1	0.3	-0.5	0.2	-0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.4	0.4	0.8	0.6	-0.9	0.3
Friendships satisfaction	0.0	0.0	0.1	0.0	0.3	0.0
Qualifications: nursing, teaching	0.3	0.5	1.3	-0.4	-1.1	0.3
Commuting to job workplace: Walk	0.1	0.2	0.4	-0.2	0.6	0.1
Eye problems/disorders: Cataract	3.2	3.7	6.3	2.5	-2.1	-0.4
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	3.3	-1.8	0.3	0.8
Medication for cholesterol	1.8	2.7	6.4	2.5	-0.9	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.4	0.4	0.6	-0.5	-0.8	-0.7
Back pain experienced in last month	0.5	0.7	1.0	-0.8	1.0	-0.6
Mineral and other dietary supplements	0.6	0.9	2.5	-1.6	0.2	-0.0
Breast cancer (self-reported)	2.0	2.4	3.9	0.6	-1.7	-2.0
Asthma (self-reported)	0.2	0.5	0.9	0.6	0.2	-1.0
Osteoporosis (self-reported)	0.4	0.5	1.3	1.2	-0.4	-0.2
Osteoarthritis (self-reported)	0.1	0.1	0.2	0.4	0.4	0.2
Medication: Aspirin	0.4	0.6	1.4	-1.2	0.5	0.0
Medication: Gliclazide	0.8	0.9	1.5	1.2	-1.1	-0.3
Illnesses of father: None of the above (group 1)	0.5	0.7	0.8	0.9	0.8	0.7
Smoking status: Current	1.9	3.1	4.0	-2.0	1.9	1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.3	2.8	3.7	1.6	1.5	1.9
Whole body water mass	0.4	2.0	3.2	1.7	-1.8	-0.0
Leg predicted mass (right)	0.2	1.3	2.0	1.4	-1.3	0.4
Arm fat mass (left)	0.1	0.3	0.4	-0.7	-0.6	0.4
Number of self-reported non-cancer illnesses	0.3	0.4	0.7	0.6	-0.5	-0.8
Average weekly champagne plus white wine intake	0.3	0.4	0.6	0.8	0.3	-0.7
Miserableness	0.1	0.2	0.4	-0.6	0.5	0.1
Guilty feelings	0.3	0.4	0.6	-0.8	0.7	0.1
Wears glasses or contact lenses	0.9	1.1	1.8	0.1	-1.3	-1.2
Ever taken oral contraceptive pill	2.6	2.9	7.5	2.7	-1.0	0.4
Hearing aid user	1.1	1.2	2.4	0.8	-0.8	-1.5
Mother’s age at death	0.0	0.1	0.1	-0.2	0.3	0.1
Financial situation satisfaction	0.5	0.6	1.4	0.7	-1.2	-0.2
Tinnitus: Yes, now most or all of the time	0.8	1.0	1.4	1.1	-1.2	-0.6
Commuting to job workplace: Public transport	0.8	0.9	2.0	-0.8	1.4	0.4
Eye problems/disorders: Glaucoma	1.7	2.1	4.5	2.1	-1.3	-0.2
Medication: Blood pressure	3.6	6.9	17.0	-4.1	1.8	0.8
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.9	-0.7	-0.9	-1.4
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.1	1.1	0.1	-0.3
High cholesterol (Self-reported)	0.2	0.4	0.6	-0.8	-0.5	-0.6
Medication: Bendroflumethiazide	1.7	2.5	6.8	-2.6	0.2	-0.8
Medication: Paracetamol	1.8	2.8	6.0	2.4	-1.3	-0.9
Medication: Lisinopril	1.5	2.0	4.8	-2.2	1.1	0.1
Medication: Atorvastatin	0.3	0.3	0.5	0.1	0.7	0.7
Illnesses of father: High blood pressure	0.8	1.0	2.6	-1.6	0.6	0.3
Alcohol drinker status: Never	2.7	3.3	5.5	-2.0	-0.4	-2.4
Ever smoked	1.3	2.2	2.9	-1.4	1.7	1.3
Basal metabolic rate	0.3	1.5	2.6	1.4	-1.6	0.1
Leg fat percentage (left)	0.3	1.2	3.1	-1.8	0.3	0.6
Arm fat-free mass (left)	0.2	0.8	1.2	1.1	-1.1	0.3
Number of operations (self-reported)	0.4	0.5	1.0	0.7	-1.0	-0.4
Average weekly beer plus cider intake	0.1	0.1	0.2	0.5	0.2	-0.1
Irritability	0.9	1.5	3.6	0.0	-1.0	-1.9
Risk taking	0.9	1.3	2.3	-1.0	1.5	0.9
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.2	0.1	-0.2	-0.4
Fractured/broken bones in last 5 years	1.5	1.9	5.4	2.3	-0.4	0.2
Age started oral contraceptive pill	0.5	0.6	1.2	-1.1	-0.3	-0.6
Diastolic blood pressure, automated reading	2.1	6.6	14.8	-3.8	2.2	0.6
Ever depressed for a whole week	0.8	1.0	1.9	-0.9	-1.4	-0.5
Unable to work because of sickness or disability	0.1	0.1	0.2	0.0	0.2	-0.4
Commuting to job workplace: Cycle	1.0	1.2	1.9	1.0	-0.8	-1.4
Myopia	0.5	0.8	1.0	-0.8	0.8	1.0
Vascular/heart problems diagnosed by doctor	4.0	11.0	27.1	5.2	-2.4	-0.3
Cholesterol lowering medication	2.5	3.7	5.1	-2.2	1.9	1.5
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	3.6	0.7	-1.9	-1.2
Pain experienced in last month	0.1	0.2	0.4	0.7	0.0	0.5
Supplements: Calcium	3.1	3.4	4.3	2.1	-1.6	-1.9
Basal cell carcinoma (self-reported)	0.6	0.7	1.2	1.0	-0.2	-1.1
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.6	-0.7	-0.8	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.3	0.4	0.6	-0.8	0.3	0.6
Heart disease (siblings)	2.2	2.7	4.3	-1.8	2.1	0.7
Alcohol drinker status: Previous	3.5	4.0	6.4	0.9	-2.2	-2.5
Pack years of smoking	0.2	0.3	0.6	-0.5	-0.8	-0.5
Impedance of whole body	0.5	2.4	6.4	-2.5	0.9	0.2
Leg fat mass (left)	0.1	0.3	0.6	-0.8	-0.4	0.3
Arm predicted mass (left)	0.3	1.5	2.2	1.5	-1.5	0.0