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chr5:139,380,991-142,230,251

Best TWAS P=1.72e-29 · Best GWAS P=3.47e-30 conditioned to 0.024

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
33	GTEx	Muscle Skeletal	NDFIP1	0.20	0.10	lasso	9	0.12	3.8e-12	-11.3	11.3	1.7e-29	-0.93	0.01	0.99	TRUE
2	CommonMind	Brain Pre-frontal Cortex	PCDHB16	0.09	0.06	blup	443	0.08	1.1e-09	-7.3	7.2	8.2e-13	-0.12	0.00	1.00	TRUE
3	CommonMind	Brain Pre-frontal Cortex	PCDHB2	0.20	0.14	bslmm	431	0.15	1.0e-17	-5.4	-6.3	2.5e-10	0.11	1.00	0.00	TRUE
23	GTEx	Cells Transformed fibroblasts	HDAC3	0.12	0.01	enet	57	0.02	1.8e-02	-2.2	5.4	5.2e-08	-0.10	0.11	0.04	TRUE
30	GTEx	Liver	NDFIP1	0.35	-0.01	enet	38	-0.01	7.8e-01	-10.0	-10.0	9.4e-24	0.48	0.04	0.59	FALSE
44	METSIM	Adipose	NDFIP1	0.23	0.15	lasso	8	0.16	7.1e-23	-7.3	-8.9	6.9e-19	0.73	1.00	0.00	FALSE
47	The Cancer Genome Atlas	Breast Invasive Carcinoma	NDFIP1	0.04	0.01	lasso	3	0.01	1.2e-03	-5.5	8.2	2.0e-16	-0.65	0.09	0.24	FALSE
45	NTR	Blood	NDFIP1	0.03	0.00	blup	610	0.01	2.9e-03	-10.0	-7.8	8.9e-15	0.63	0.02	0.96	FALSE
46	YFS	Blood	NDFIP1	0.04	0.01	enet	14	0.03	2.3e-10	9.3	-7.5	4.7e-14	0.45	1.00	0.00	FALSE
5	CommonMind	Brain Pre-frontal Cortex	PCDHB5	0.13	0.04	enet	10	0.05	1.0e-06	-6.1	-7.1	1.2e-12	0.12	0.08	0.92	FALSE
39	GTEx	Skin Sun Exposed Lower leg	GNPDA1	0.11	0.00	enet	23	0.00	1.5e-01	9.3	7.1	1.3e-12	-0.69	0.02	0.92	FALSE
14	GTEx	Artery Tibial	PCDHB2	0.19	0.04	enet	21	0.13	2.5e-10	-5.4	-6.8	9.2e-12	0.15	0.03	0.97	FALSE
24	GTEx	Colon Transverse	PCDHB2	0.19	0.06	lasso	4	0.09	4.1e-05	2.9	-6.5	1.1e-10	0.12	0.03	0.90	FALSE
10	GTEx	Artery Aorta	PCDHB2	0.17	0.03	lasso	3	0.11	1.4e-06	3.7	-6.4	1.4e-10	0.12	0.74	0.10	FALSE
26	GTEx	Esophagus Muscularis	PCDHB2	0.12	0.11	lasso	3	0.09	4.3e-06	-5.3	-6.3	3.2e-10	0.10	0.18	0.81	FALSE
7	GTEx	Adipose Subcutaneous	PCDHB2	0.11	0.08	enet	27	0.05	1.0e-04	3.5	-6.2	4.0e-10	0.12	0.59	0.38	FALSE
27	GTEx	Heart Atrial Appendage	PCDHB2	0.16	0.09	enet	18	0.07	3.7e-04	-5.5	-6.2	4.8e-10	0.08	0.26	0.58	FALSE
32	GTEx	Muscle Skeletal	PCDHB2	0.06	0.01	enet	10	0.01	3.7e-02	3.5	-6.2	4.8e-10	0.12	0.07	0.87	FALSE
18	GTEx	Breast Mammary Tissue	PCDHB10	0.32	0.15	lasso	8	0.18	2.4e-09	-6.4	6.2	5.4e-10	-0.08	0.68	0.32	FALSE
34	GTEx	Nerve Tibial	PCDHB2	0.23	0.04	enet	18	0.14	2.5e-10	-5.4	-6.2	6.8e-10	0.12	0.84	0.16	FALSE
4	CommonMind	Brain Pre-frontal Cortex	PCDHB3	0.26	0.19	bslmm	428	0.21	1.0e-24	-5.3	-6.0	1.4e-09	0.10	1.00	0.00	FALSE
43	GTEx	Uterus	PCDHB16	0.38	0.03	enet	14	0.06	2.7e-02	-3.7	6.0	2.5e-09	-0.09	0.07	0.35	FALSE
38	GTEx	Skin Not Sun Exposed Suprapubic	PCDHB12	0.11	0.06	lasso	5	0.04	3.0e-03	-6.1	-5.9	4.5e-09	0.07	0.06	0.83	FALSE
28	GTEx	Heart Left Ventricle	PCDHB5	0.11	0.05	lasso	3	0.06	5.3e-04	-7.3	-5.9	4.7e-09	0.08	0.01	0.95	FALSE
12	GTEx	Artery Aorta	PCDHB15	0.16	0.03	enet	19	0.12	4.1e-07	-4.1	-5.8	4.9e-09	0.10	0.04	0.93	FALSE
19	GTEx	Breast Mammary Tissue	PCDHB9	0.11	0.04	lasso	5	0.02	1.9e-02	-6.1	5.8	5.8e-09	-0.06	0.20	0.50	FALSE
16	GTEx	Brain Cerebellum	PCDHB10	0.27	0.24	enet	9	0.23	1.8e-07	-6.1	5.8	9.0e-09	-0.07	0.43	0.51	FALSE
8	GTEx	Adipose Subcutaneous	PCDHB12	0.18	0.03	lasso	7	0.05	3.2e-05	4.7	-5.7	1.4e-08	0.08	0.83	0.14	FALSE
37	GTEx	Skin Not Sun Exposed Suprapubic	GNPDA1	0.18	0.02	lasso	8	0.01	6.2e-02	-7.1	5.6	1.8e-08	-0.56	0.04	0.66	FALSE
29	GTEx	Heart Left Ventricle	PCDHB12	0.21	0.07	lasso	5	0.15	1.7e-08	4.5	-5.6	2.1e-08	0.05	0.43	0.56	FALSE
22	GTEx	Breast Mammary Tissue (Male)	PCDHB16	0.43	0.24	enet	8	0.22	7.8e-06	-6.1	5.5	3.1e-08	-0.08	0.22	0.52	FALSE
11	GTEx	Artery Aorta	PCDHB3	0.10	0.01	enet	14	0.02	4.8e-02	3.6	-5.5	3.5e-08	0.12	0.14	0.04	FALSE
20	GTEx	Breast Mammary Tissue	PCDHB16	0.47	0.22	lasso	3	0.35	1.2e-18	-6.1	5.5	4.5e-08	-0.06	0.73	0.27	FALSE
36	GTEx	Pituitary	PCDHB12	0.29	0.15	lasso	5	0.23	1.4e-06	-3.3	-5.5	4.5e-08	0.04	0.12	0.78	FALSE
40	GTEx	Testis	PCDHB3	0.39	0.24	lasso	16	0.20	4.6e-09	-5.3	5.5	4.7e-08	-0.07	0.98	0.02	FALSE
15	GTEx	Brain Cerebellar Hemisphere	PCDHB10	0.43	0.17	enet	20	0.24	9.8e-07	-6.4	5.5	4.8e-08	-0.07	0.50	0.35	FALSE
41	GTEx	Testis	PCDHB9	0.18	0.06	lasso	2	0.06	1.6e-03	-4.1	-5.5	5.0e-08	0.10	0.22	0.52	FALSE
35	GTEx	Nerve Tibial	PCDHB14	0.15	0.12	lasso	4	0.12	1.7e-08	4.5	5.4	5.8e-08	-0.08	0.98	0.02	FALSE
9	GTEx	Adrenal Gland	ZMAT2	0.21	0.05	lasso	6	0.07	1.5e-03	4.7	5.4	6.8e-08	-0.08	0.05	0.70	FALSE
6	CommonMind	Brain Pre-frontal Cortex	PCDHB7	0.19	0.13	lasso	11	0.15	6.8e-18	4.5	5.4	7.5e-08	-0.08	1.00	0.00	FALSE
21	GTEx	Breast Mammary Tissue (Male)	PCDHB10	0.35	-0.01	lasso	6	0.02	1.1e-01	-6.1	5.3	1.3e-07	-0.04	0.08	0.34	FALSE
42	GTEx	Thyroid	PCDHB2	0.07	0.02	lasso	6	0.03	2.4e-03	-3.8	-5.3	1.3e-07	0.12	0.15	0.27	FALSE
25	GTEx	Esophagus Gastroesophageal Junction	PCDHB2	0.22	0.12	lasso	11	0.10	1.3e-04	-4.1	-5.2	1.6e-07	0.10	0.21	0.54	FALSE
1	CommonMind	Brain Pre-frontal Cortex	PCDHB10	0.13	0.11	lasso	4	0.13	3.0e-15	4.7	5.2	1.8e-07	-0.07	0.99	0.01	FALSE
13	GTEx	Artery Aorta	PCDHB9	0.21	0.06	enet	24	0.14	4.2e-08	-3.7	5.2	2.2e-07	-0.06	0.33	0.65	FALSE
17	GTEx	Brain Frontal Cortex BA9	PCDHB10	0.31	0.22	enet	19	0.21	3.1e-06	4.7	5.2	2.5e-07	-0.07	0.23	0.21	FALSE
31	GTEx	Lung	PCDHB10	0.21	0.12	enet	18	0.12	1.2e-09	4.7	5.1	2.9e-07	-0.06	1.00	0.00	FALSE
48	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	PCDHB8	0.07	0.03	blup	82	0.04	2.7e-03	3.5	-5.1	3.0e-07	0.07	0.01	0.03	FALSE