Best TWAS P=7.24e-35 · Best GWAS P=1.85e-85 conditioned to 1.08e-22
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | LEPR | 0.07 | 0.05 | enet | 15 | 0.06 | 5.1e-08 | -9.3 | -9.3 | 1.4e-20 | 0.29 | 0.98 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | WDR78 | 0.13 | 0.14 | lasso | 3 | 0.14 | 1.7e-16 | 6.1 | -6.1 | 9.9e-10 | 0.00 | 0.03 | 0.97 | FALSE |
| 3 | GTEx | Artery Tibial | WDR78 | 0.14 | 0.09 | lasso | 8 | 0.09 | 2.1e-07 | 6.4 | -5.8 | 8.4e-09 | -0.05 | 0.95 | 0.04 | FALSE |
| 4 | GTEx | Artery Tibial | MIER1 | 0.12 | 0.08 | lasso | 4 | 0.07 | 6.3e-06 | 6.2 | 6.2 | 7.4e-10 | 0.02 | 0.87 | 0.11 | FALSE |
| 5 | GTEx | Breast Mammary Tissue | MIER1 | 0.12 | 0.07 | lasso | 2 | 0.05 | 8.5e-04 | 6.1 | 6.1 | 1.1e-09 | 0.03 | 0.20 | 0.48 | FALSE |
| 6 | GTEx | Breast Mammary Tissue (Female) | MIER1 | 0.21 | -0.01 | lasso | 6 | 0.00 | 4.3e-01 | 6.1 | 6.0 | 2.2e-09 | 0.01 | 0.05 | 0.51 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | MIER1 | 0.19 | 0.09 | lasso | 7 | 0.10 | 3.1e-08 | 6.1 | 7.3 | 3.8e-13 | 0.02 | 0.02 | 0.98 | TRUE |
| 8 | GTEx | Esophagus Muscularis | MIER1 | 0.14 | 0.05 | enet | 9 | 0.04 | 2.5e-03 | 6.4 | 6.6 | 3.1e-11 | 0.01 | 0.09 | 0.78 | FALSE |
| 9 | GTEx | Nerve Tibial | WDR78 | 0.13 | 0.07 | lasso | 5 | 0.06 | 7.5e-05 | 6.4 | -5.8 | 6.1e-09 | -0.03 | 0.74 | 0.12 | FALSE |
| 10 | GTEx | Testis | WDR78 | 0.45 | 0.42 | lasso | 6 | 0.40 | 5.0e-19 | 6.4 | 6.5 | 1.0e-10 | 0.02 | 0.98 | 0.02 | FALSE |
| 11 | GTEx | Thyroid | WDR78 | 0.12 | 0.11 | lasso | 3 | 0.09 | 2.4e-07 | 6.2 | -6.3 | 3.0e-10 | -0.03 | 0.97 | 0.02 | FALSE |
| 12 | GTEx | Whole Blood | TCTEX1D1 | 0.05 | 0.01 | enet | 10 | 0.02 | 9.9e-03 | -2.5 | -5.4 | 6.1e-08 | 0.02 | 0.23 | 0.04 | TRUE |
| 13 | METSIM | Adipose | LEPR | 0.16 | 0.08 | bslmm | 540 | 0.09 | 4.1e-13 | 9.0 | -5.3 | 1.4e-07 | 0.04 | 1.00 | 0.00 | TRUE |
| 14 | METSIM | Adipose | LEPROT | 0.08 | 0.04 | enet | 8 | 0.05 | 9.3e-08 | -3.3 | -5.8 | 6.4e-09 | 0.15 | 0.96 | 0.00 | TRUE |
| 15 | METSIM | Adipose | MIER1 | 0.05 | 0.05 | enet | 19 | 0.04 | 2.8e-07 | 6.1 | 6.2 | 4.3e-10 | 0.01 | 0.20 | 0.80 | FALSE |
| 16 | NTR | Blood | LEPROT | 0.10 | 0.05 | lasso | 6 | 0.09 | 1.1e-26 | 9.0 | -7.2 | 5.8e-13 | 0.24 | 1.00 | 0.00 | TRUE |
| 17 | ROSMAP | Brain Pre-frontal Cortex | LEPR | 0.09 | 0.07 | blup | 505 | 0.06 | 4.6e-08 | 8.7 | -12.3 | 7.2e-35 | 0.29 | 1.00 | 0.00 | TRUE |
| 18 | YFS | Blood | LEPROT | 0.40 | 0.25 | enet | 52 | 0.38 | 2.0e-133 | 8.8 | -7.5 | 9.0e-14 | 0.22 | 1.00 | 0.00 | FALSE |
| 19 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LEPR | 0.13 | 0.02 | blup | 142 | 0.07 | 3.9e-08 | 7.3 | -6.9 | 4.4e-12 | 0.26 | 0.44 | 0.06 | TRUE |
| 20 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PDE4B | 0.03 | 0.00 | blup | 320 | 0.01 | 3.5e-02 | 7.2 | 5.5 | 3.7e-08 | -0.16 | 0.18 | 0.02 | TRUE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | JAK1 | 0.04 | 0.01 | blup | 91 | 0.02 | 9.2e-03 | 5.7 | -6.8 | 1.5e-11 | 0.06 | 0.01 | 0.88 | TRUE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | JAK1 | 0.08 | 0.06 | enet | 9 | 0.06 | 2.0e-06 | 5.9 | -6.1 | 1.2e-09 | 0.06 | 0.01 | 0.99 | FALSE |
| 23 | The Cancer Genome Atlas | Thyroid Carcinoma | LEPR | 0.09 | 0.01 | enet | 24 | 0.07 | 6.1e-07 | -9.3 | -7.1 | 1.3e-12 | 0.16 | 0.08 | 0.04 | TRUE |
| 24 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC35D1 | 0.13 | 0.10 | enet | 16 | 0.20 | 9.2e-19 | 7.7 | 6.1 | 9.5e-10 | 0.00 | 0.01 | 0.99 | FALSE |
| 25 | The Cancer Genome Atlas | Thyroid Carcinoma | TCTEX1D1 | 0.03 | 0.00 | blup | 72 | 0.01 | 4.5e-02 | 3.6 | -5.2 | 2.1e-07 | -0.01 | 0.01 | 0.72 | FALSE |