Hub : Genes

BCAR3

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0410 0.0190 3.9e-03 0.006 0.017 0.003 0.017 0.001 5.3e-02 3.1e-03 1.1e-01 0.0031 2.0e-01
2 GTEx Artery Aorta 0.1930 0.0580 2.5e-04 0.051 NA 0.074 NA 0.085 8.9e-04 NA 6.5e-05 NA 1.9e-05
3 GTEx Artery Tibial 0.1095 0.0462 1.5e-03 0.120 NA 0.114 NA 0.120 1.1e-09 NA 3.1e-09 NA 1.1e-09
4 GTEx Cells Transformed fibroblasts 0.0820 0.0350 3.8e-03 0.033 NA 0.008 NA 0.018 1.7e-03 NA 7.1e-02 NA 1.5e-02
5 GTEx Muscle Skeletal 0.0757 0.0315 6.5e-03 0.002 NA 0.018 NA 0.008 2.0e-01 NA 6.4e-03 NA 4.9e-02
6 GTEx Thyroid 0.0940 0.0380 9.0e-03 0.004 NA -0.003 NA -0.002 1.4e-01 NA 7.3e-01 NA 5.7e-01
7 ROSMAP Brain Pre-frontal Cortex 0.0390 0.0180 1.1e-02 0.016 0.000 0.018 0.014 0.012 2.9e-03 2.8e-01 1.7e-03 0.0055 9.3e-03
8 TCGA Breast Invasive Carcinoma 0.0237 0.0139 3.4e-03 0.016 0.012 0.006 NA 0.014 2.0e-04 1.4e-03 1.7e-02 NA 6.2e-04
9 TCGA Cervical Squamous Cell Carcinoma 0.1050 0.0570 8.5e-03 0.007 0.014 0.016 NA 0.007 1.3e-01 6.6e-02 5.1e-02 NA 1.3e-01
10 TCGA Kidney Renal Clear Cell Carcinoma 0.1169 0.0526 2.4e-05 0.028 0.063 0.074 NA 0.058 3.2e-04 1.2e-07 9.8e-09 NA 3.6e-07
11 TCGA Brain Lower Grade Glioma 0.0534 0.0254 1.7e-03 0.013 0.022 0.009 NA 0.005 1.2e-02 1.4e-03 3.1e-02 NA 7.1e-02
12 TCGA Prostate Adenocarcinoma 0.3573 0.0591 0.0e+00 0.300 0.263 0.301 NA 0.304 9.1e-32 2.0e-27 6.8e-32 NA 3.0e-32

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11 12
Bipolar Disorder (2018) 0.9 1.5 5.6 0.8 -0.5 -0.4 -1.1 0.2 1.9 2.1 -0.5 -0.3 1.0 2.4 0.6
Bipolar Disorder or Schizophrenia 0.7 1.8 5.5 1.0 0.9 1.2 -1.5 -1.1 2.1 1.2 -1.0 -0.2 1.1 2.3 -1.0
Depressed Affect (Nagel 2018) 1.5 3.2 9.7 -1.6 -1.1 -1.6 0.0 1.7 -0.6 3.1 0.6 -3.1 1.9 -0.7 2.1
Depression (Nagel 2018) 0.4 0.6 3.1 0.0 -0.1 -0.4 -0.0 0.6 0.2 1.8 1.2 -0.8 1.1 0.0 0.6
Intelligence (Savage-Jansen 2018) 0.3 0.8 2.9 1.7 0.3 0.4 -0.7 1.0 0.1 -1.0 -1.4 0.7 -1.4 -0.4 -0.3
Neuroticism (Nagel 2018) 1.3 3.1 13.4 -0.7 -0.8 -1.2 0.4 1.8 -0.1 3.3 0.9 -3.7 2.0 -0.5 1.6
Schizophrenia (2018) 0.7 1.4 3.7 0.6 1.6 1.9 -1.0 -1.6 1.2 -0.0 -0.8 0.0 0.6 1.1 -1.8
Schizophrenia vs Biploar Disorder 0.7 0.9 2.5 -0.8 0.4 0.7 -0.1 -1.0 -1.3 -1.4 -0.5 -0.7 -1.0 -1.6 -0.7
Worry (Nagel 2018) 0.6 1.2 5.7 0.3 -0.1 -0.4 0.8 1.5 0.0 1.5 1.1 -2.4 1.0 0.0 0.7
Alzheimer’s Disease (in mother) 0.6 0.8 2.4 1.6 -0.2 -0.6 1.4 -0.1 -0.7 0.9 0.9 1.2 0.4 0.0 0.6
Alzheimer’s Disease (in father) 0.2 0.3 1.0 0.2 0.4 0.2 0.3 0.0 0.2 0.2 1.0 -1.0 0.8 0.2 -0.3
Alzheimer’s Disease (including proxy) 0.6 0.9 2.0 1.4 -0.6 -1.1 0.7 0.7 -0.7 1.4 1.0 -0.1 0.6 0.3 1.4
Crohns Disease (2017) 1.0 2.2 7.0 1.4 2.3 2.6 -0.4 -0.9 -0.9 -0.0 -0.8 0.0 1.6 0.7 -2.6
Irritable Bowel Disease (IBD) 0.6 1.4 3.4 1.0 1.7 1.9 -0.2 -0.9 -1.0 0.7 -0.6 -0.0 1.8 0.5 -1.7
Ulcerative Colitis (UC) 0.2 0.4 1.7 0.6 0.5 0.4 -0.1 -0.6 -0.4 1.3 -0.4 0.3 1.3 0.1 -0.2
Major Depression (MDD) 0.6 0.8 2.8 -0.7 1.0 0.8 -0.3 -0.3 0.7 1.2 0.1 -0.2 1.7 1.4 -0.5
Reaction Time 2.5 4.8 8.5 -2.9 -2.6 -2.3 -1.2 1.2 -2.3 -2.0 -0.8 -2.1 -2.8 -2.6 2.2
Verbal and Numeric Reasoning (VNR) 0.5 1.1 4.0 0.9 -0.3 -0.5 -1.3 2.0 0.5 -1.0 -1.6 0.7 -1.5 -0.1 0.5
Breast Cancer 0.5 1.2 4.0 0.1 -0.4 -0.2 1.9 -0.2 -2.0 -0.6 1.4 -1.1 -1.1 -1.1 -0.0
Ovarian Cancer 0.1 0.1 0.4 0.0 -0.2 -0.3 0.2 0.4 -0.4 0.6 -0.1 0.2 0.4 0.5 0.3
Prostate Cancer 0.3 0.5 1.5 0.6 -0.1 0.3 -0.8 -0.0 0.8 0.5 -1.2 0.7 -0.2 1.1 -0.5
Age at First Birth 0.2 0.2 1.4 0.2 -0.0 0.3 -0.2 0.5 -0.3 -0.3 -0.4 -1.2 -0.6 -0.3 -0.5
Bipolar Disorder (2011) 0.7 0.7 2.6 0.1 -1.2 -1.1 -0.8 1.6 -0.1 0.8 -0.8 0.5 -0.2 0.5 0.8
Body Mass Index (BMI) (2010) 0.6 0.8 2.8 1.6 -0.4 -0.3 1.7 -0.2 0.3 0.9 1.6 -0.2 0.2 -0.3 0.3
Coronary Artery Disease (CAD) 0.4 0.4 1.1 -0.9 -0.1 -0.0 -0.8 -1.1 -0.7 -0.3 -0.3 -0.6 -1.1 -0.5 -0.3
Crohns Disease (2012) 0.3 0.5 3.0 0.5 0.4 0.7 0.1 -0.3 -1.7 -0.3 -0.4 -0.9 -0.1 -0.5 -0.8
Mean Putamen Volume 1.5 1.7 6.5 -0.1 -1.0 -0.9 -2.0 0.7 2.5 1.5 -0.8 0.3 0.2 1.9 0.8
Fasting Glucose 0.6 0.7 2.2 -0.5 -1.5 -1.2 0.6 0.2 0.6 0.5 0.1 -0.6 0.3 -0.8 1.5
HbA1C 1.2 1.3 2.5 1.6 0.8 1.1 1.3 -0.2 1.6 -0.1 1.4 0.9 -0.3 1.5 -1.4
HDL Cholesterol 0.2 0.3 0.9 -1.0 0.9 0.6 -0.4 -0.0 0.2 0.4 -0.3 0.6 0.3 0.5 -0.6
LDL Cholesterol 1.7 2.7 7.6 -2.6 -1.4 -1.4 -0.5 -0.0 -0.5 -2.8 -0.4 -0.1 -2.5 -2.4 1.4
Lupus 1.1 1.7 6.6 -2.6 -1.3 -1.7 -1.5 -0.7 -0.2 1.0 -1.2 -0.8 -0.3 -0.1 1.6
Neuroticism (2016) 0.5 0.7 4.1 -0.9 0.2 0.0 -0.7 -1.1 -0.4 0.8 -0.8 -2.0 0.2 -0.4 0.1
Primary Biliary Cirrhosis 0.6 0.9 3.5 0.8 0.7 0.7 1.4 0.7 0.5 -1.2 1.0 1.9 -0.3 -0.2 -0.5
Rheumatoid Arthritis 0.6 0.8 2.2 -0.6 -0.4 -0.9 1.5 -1.1 0.0 0.0 1.4 -0.5 -0.1 -1.5 0.7
Schizophrenia (2014) 0.3 0.8 2.8 -0.2 0.4 0.7 -1.0 -1.4 1.7 0.2 -0.5 -0.6 0.2 1.3 -0.5
Triglycerides 0.5 0.7 3.8 0.7 0.5 0.5 -0.4 -0.8 2.0 0.4 0.5 0.9 0.7 1.0 -0.7
Type 2 Diabetes (T2D) (2012) 0.9 1.0 4.4 -1.1 -1.4 -1.9 0.3 0.2 0.2 0.6 -0.7 -0.1 0.0 0.1 2.1
Ulcerative Colitis 0.5 0.8 1.8 -0.4 -1.1 -1.3 0.9 0.5 -1.1 0.5 0.3 -0.6 0.1 -1.2 1.4
Blood Eosinophil Count 0.7 5.7 25.5 5.0 1.9 1.3 1.4 -2.0 1.2 2.2 1.5 2.0 3.2 2.8 -1.1
Blood Platelet Count 0.6 6.9 22.5 2.4 0.3 -0.6 -2.7 -3.9 1.6 4.7 -1.3 0.6 4.1 3.1 1.0
Blood Red Count 0.3 3.0 6.4 -2.0 -1.5 -2.4 2.0 1.1 -0.2 2.1 2.0 -0.6 0.8 -1.5 2.5
Blood White Count 1.3 9.3 32.3 0.1 -3.7 -5.2 -0.7 2.3 0.4 5.2 0.2 -1.2 2.0 -0.1 5.7
Heel T-Score 0.3 2.2 6.2 -0.2 -0.5 -0.6 -0.3 0.9 -2.5 -1.7 -1.7 0.8 -2.5 -2.5 -0.4
BMI 0.6 3.6 15.3 -0.2 -1.2 -1.8 -0.4 0.1 2.0 3.9 1.3 -2.6 1.9 1.5 2.0
Height 0.3 6.0 18.2 -1.7 4.3 3.8 -1.0 -2.9 -1.7 -0.6 -2.4 0.8 1.7 -0.0 -3.9
Waist Hip Ratio (WHR) 2.0 9.0 27.2 2.0 4.9 5.0 -0.1 -2.6 1.7 0.7 0.0 2.1 2.7 2.3 -5.2
Systolic Blood Pressure 1.5 7.6 16.4 3.1 3.5 3.1 1.9 -1.7 1.0 3.4 2.5 0.8 4.0 2.9 -3.0
Smoking Status 1.6 3.8 9.8 2.4 2.9 2.6 1.2 -0.2 0.5 2.5 1.2 0.7 3.1 0.8 -2.2
Allergy or Eczema 0.5 1.2 4.3 2.1 0.6 0.6 0.4 -2.0 1.1 -1.3 0.4 0.5 0.1 1.3 -0.6
Cardiovascular Disease 1.5 5.0 11.6 2.2 3.0 2.5 0.5 -2.6 1.2 3.0 0.9 1.0 3.4 1.8 -2.4
Hypothyroidism (self reported) 0.7 1.6 4.0 0.5 -1.3 -1.5 1.5 0.7 -0.4 2.0 1.0 -1.7 0.3 -0.7 1.8
Respiratory disease 0.2 0.3 2.0 0.6 -0.1 0.1 0.2 -1.4 0.2 -0.1 0.2 -1.3 0.1 -0.1 -0.1
Type 2 Diabetes (T2D) (2018) 0.4 0.8 4.2 -0.6 -0.9 -0.8 -0.4 0.1 -0.9 2.0 -0.5 -1.1 0.4 -0.8 0.7
Lung FEV1/FVC ratio 0.8 4.1 13.1 3.2 0.4 0.7 3.6 2.7 1.2 1.5 3.3 0.7 1.2 0.9 -0.6
Lung FVC 0.6 3.1 9.2 -0.0 3.0 2.8 -1.1 -1.1 1.0 0.5 -0.7 1.4 2.1 1.7 -2.6
Neuroticism 1.7 4.0 8.7 -1.0 -2.4 -2.6 0.8 2.1 -1.5 2.1 0.7 -3.0 0.1 -2.5 2.7
Chronotype (morning person) 0.3 0.6 1.3 0.2 -1.1 -1.1 -0.2 1.2 1.0 0.6 0.1 -0.8 0.2 0.8 1.0
Hair Pigment 0.3 9.8 23.1 4.8 4.0 3.9 0.9 -2.2 0.6 1.4 -0.5 4.8 3.7 2.5 -3.6
Tanning 0.0 0.5 2.0 0.9 1.4 1.0 0.8 0.1 -0.1 -0.2 0.3 0.7 0.4 0.4 -0.9
Hand grip strength (left) 1.8 4.9 10.2 0.9 3.0 2.2 -1.6 -0.8 2.1 2.1 -1.7 2.5 2.7 3.2 -2.1
Number of treatments/medications taken 0.4 0.8 3.7 -0.1 -0.1 -0.6 0.2 -1.0 -0.3 1.9 0.6 -1.2 1.2 -0.5 0.8
Average weekly spirits intake 0.7 0.9 4.7 -0.3 -0.4 -0.7 -1.1 0.5 2.2 0.8 -0.2 0.0 -0.1 1.6 0.5
Sensitivity / hurt feelings 3.0 5.1 11.2 -1.9 -3.3 -3.3 -0.6 2.0 -1.7 -0.3 -1.1 -1.9 -2.0 -2.9 3.2
Frequency of depressed mood in last 2 weeks 0.8 1.1 4.6 0.6 -0.8 -0.8 1.3 2.1 -0.9 -0.2 1.4 0.2 -0.6 -0.9 0.9
Hearing difficulty/problems: Yes 0.6 0.9 3.9 0.6 -1.4 -0.9 -0.1 -0.1 0.3 -1.4 0.3 1.2 -2.0 -0.0 0.7
Relative age of first facial hair 0.5 1.0 5.0 1.6 -0.2 -0.2 0.7 0.7 0.7 0.6 0.5 2.2 -0.4 1.6 0.1
Other serious medical condition/disability diagnosed by doctor 0.7 0.9 2.4 -0.4 -1.1 -1.2 0.5 0.9 -0.6 0.6 0.2 -1.6 0.3 -1.5 1.3
Ever used hormone-replacement therapy (HRT) 0.7 0.9 2.8 -0.8 0.6 0.6 -0.9 -1.7 -1.5 1.1 -0.6 -1.0 1.0 -0.1 -0.6
Ever had hysterectomy (womb removed) 0.8 0.9 4.0 -2.0 0.4 -0.0 -1.4 -0.5 -0.9 -0.7 -1.4 0.7 0.1 -0.8 0.1
Systolic blood pressure, automated reading 0.9 2.7 10.9 0.9 0.9 0.8 1.9 -1.0 -0.7 3.3 2.1 -0.6 2.9 0.8 -0.6
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 1.4 -1.2 -0.3 -0.4 -0.7 0.2 -0.5 0.5 -0.3 -0.7 0.1 -0.0 0.5
Angina 0.5 0.6 2.2 1.3 -0.1 -0.4 -0.2 0.5 -0.2 1.5 -0.3 1.2 1.1 0.3 0.4
Medication for hormone replacement therapy 0.8 0.9 2.9 -0.8 -1.1 -1.6 -0.2 -0.0 -1.2 1.1 0.1 -0.7 0.6 -0.3 1.7
Vitamin and mineral supplements 0.2 0.3 0.8 -0.9 -0.1 0.4 0.2 0.7 0.8 -0.7 0.6 0.2 -0.5 0.6 -0.5
Supplements: Zinc 0.1 0.1 0.2 0.4 -0.4 -0.5 0.3 -0.1 0.3 0.3 0.3 -0.2 -0.1 -0.2 0.4
Medication: Co-codamol 2.2 2.6 6.7 -1.1 -2.5 -2.6 -0.1 1.5 -0.6 0.8 -0.0 -1.8 -1.0 -1.7 2.6
Medication: Metformin 0.7 0.9 4.6 -2.1 -0.5 -0.2 -1.8 0.4 -0.2 0.6 -1.5 -0.0 -0.1 -0.3 0.2
Diabetes (father) 0.7 0.9 2.3 1.1 -0.8 -0.6 1.5 0.9 1.5 0.3 1.5 -0.5 -0.1 0.1 0.7
Diabetes (mother) 0.2 0.3 0.6 0.7 -0.1 -0.2 0.4 0.6 0.7 0.5 0.7 0.8 0.2 0.4 0.3
Severe depression (siblings) 0.7 0.7 2.4 1.0 0.1 0.2 1.1 -0.6 0.4 1.2 1.5 -0.4 0.9 1.1 -0.1
Pack years adult smoking proportion 0.4 0.7 3.8 -0.1 0.0 -0.1 0.7 0.5 -0.2 0.6 1.7 -1.9 0.2 -0.1 0.1
Impedance of leg (right) 0.3 1.4 3.5 -0.2 -1.4 -1.4 -0.8 0.4 -1.5 -0.8 -1.9 1.8 -1.0 -0.5 1.2
Leg fat-free mass (left) 0.2 1.1 2.3 0.1 1.5 1.3 0.2 -0.7 1.4 1.3 0.3 -0.1 1.5 0.7 -1.2
Trunk fat percentage 0.8 3.3 9.1 -0.9 -2.4 -2.6 1.3 1.0 -0.4 3.0 1.5 -1.6 0.8 -1.1 2.8
Hand grip strength (right) 1.3 3.5 7.2 0.6 2.7 2.1 -0.7 -0.8 2.1 2.0 -0.9 2.0 2.2 2.5 -2.1
Townsend deprivation index at recruitment 0.4 0.6 1.8 1.2 -0.3 -0.6 0.1 0.9 -0.3 1.2 -0.0 1.4 0.7 -0.3 0.7
Current tobacco smoking 1.0 1.7 5.3 1.8 0.8 0.6 1.2 1.8 0.9 2.3 1.4 0.8 1.3 0.5 -0.4
Average weekly fortified wine intake 0.6 0.6 1.6 0.6 1.0 0.8 -0.4 -1.2 -1.3 0.7 -0.6 0.8 0.7 0.1 -0.8
Maternal smoking around birth 0.8 1.1 3.8 0.2 -1.1 -1.2 1.3 -1.0 -0.4 1.9 1.2 -0.4 0.8 -0.8 1.3
Fed-up feelings 0.6 1.1 5.0 -0.3 0.0 -0.6 0.2 1.3 -0.2 2.2 0.8 -1.4 1.6 0.7 0.8
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 1.3 1.1 -0.0 0.0 1.0 0.8 -1.1 0.7 1.0 0.6 0.1 -0.6 0.0
Relative age voice broke 0.9 1.4 6.2 -0.4 -1.3 -0.9 1.4 0.8 -0.7 -1.6 1.1 0.1 -2.5 -0.3 0.7
Taking other prescription medications 0.8 1.2 5.2 0.3 -0.5 -0.6 1.3 0.1 0.4 2.3 1.6 -0.7 1.8 -0.2 0.6
Age when periods started (menarche) 0.1 0.3 1.9 -0.1 -0.5 -0.4 0.4 0.1 0.3 0.6 1.4 -0.7 0.5 0.0 0.4
Bilateral oophorectomy (both ovaries removed) 0.6 0.7 3.6 -0.3 0.2 0.6 -1.1 0.3 -1.9 0.1 -1.5 0.0 0.3 -0.5 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 1.7 3.9 8.3 -2.2 -2.7 -2.5 -1.1 2.0 -1.2 -0.7 -1.2 -1.6 -2.9 -2.2 2.0
Tinnitus: Yes, but not now, but have in the past 0.5 0.6 1.4 0.1 0.9 1.2 0.8 -0.4 -0.5 -0.7 0.0 1.2 0.1 -0.2 -1.2
Qualifications: CSEs or equivalent 0.6 0.8 2.4 0.1 1.0 1.1 -0.4 -0.8 -0.3 0.7 -0.8 1.3 1.5 0.1 -1.0
Serious illness, injury or assault to yourself 0.9 1.1 3.3 1.8 -0.3 -0.2 0.4 0.4 1.4 1.6 1.0 0.6 1.1 1.2 0.6
High blood pressure 1.7 4.7 12.3 2.5 2.1 1.8 0.7 -2.9 1.6 3.5 1.4 0.2 2.9 2.3 -1.9
Hayfever, allergic rhinitis or eczema 0.3 0.6 2.5 1.6 0.3 0.2 0.7 -1.1 0.1 -1.4 0.2 0.5 -0.1 0.3 -0.3
Multivitamins +/- minerals 0.1 0.1 0.8 0.9 -0.1 -0.2 -0.3 -0.4 0.1 0.5 -0.4 0.0 -0.1 0.2 0.3
Stomach or abdominal pain in last month 0.5 0.7 3.4 -1.3 -0.6 -0.2 -0.1 0.1 -0.2 0.5 -0.1 -1.8 -0.9 -1.1 -0.0
Supplements: Glucosamine 1.3 1.7 10.9 0.6 0.3 0.2 -1.0 -1.4 3.3 0.3 -0.4 0.1 0.2 2.3 -0.3
Diverticular disease/diverticulitis (self-reported) 1.1 1.3 5.5 -1.3 -1.2 -1.5 -1.0 2.3 -0.7 -0.0 -1.0 -0.3 -0.4 -0.8 1.3
Medication: Atenolol 1.4 1.8 3.5 1.8 1.8 1.7 -0.1 -0.9 -0.4 1.5 0.1 0.6 1.9 1.4 -1.7
Medication: Levothyroxine sodium 0.7 1.2 2.9 -0.1 -1.6 -1.5 1.7 0.8 -0.8 0.7 1.0 -0.3 -0.7 -1.2 1.4
Sitting height 0.3 2.0 5.7 0.7 2.0 1.8 -0.3 -1.7 0.4 0.2 -1.7 2.4 1.0 0.5 -1.8
Chronic bronchitis/emphysema (father) 0.5 0.6 2.6 -0.6 0.1 0.3 -0.4 0.3 -1.2 -0.5 -1.4 0.1 -0.7 -1.6 -0.3
High blood pressure (mother) 1.1 1.6 2.9 1.0 1.6 1.5 0.8 -1.1 1.7 -1.0 0.8 1.3 0.3 1.7 -1.4
Body mass index (BMI) 0.6 2.6 10.8 0.0 -0.8 -1.2 0.5 0.5 2.0 3.3 1.8 -1.7 1.8 1.3 1.6
Impedance of leg (left) 0.2 0.8 2.8 0.3 -0.7 -0.8 -0.2 -0.2 -1.7 -0.2 -1.2 1.6 -0.2 -0.5 0.7
Leg predicted mass (left) 0.2 0.9 2.0 0.0 1.4 1.2 0.2 -0.6 1.4 1.3 0.3 -0.1 1.4 0.6 -1.1
Trunk fat mass 0.5 2.1 10.8 -0.4 -1.3 -1.6 0.9 0.5 0.4 3.3 1.2 -1.3 1.5 -0.3 1.8
Waist circumference 0.6 2.2 11.1 0.5 -0.6 -0.9 1.0 -0.0 1.5 3.3 1.8 -1.2 1.9 0.9 1.2
Number of incorrect matches in round 1.1 1.8 5.3 -1.9 -0.8 -0.8 0.2 -0.8 -2.3 2.2 0.3 -1.4 1.6 -0.5 0.8
Past tobacco smoking 1.1 1.9 6.3 0.1 -2.5 -2.3 0.4 1.0 1.0 -0.7 0.3 0.1 -2.1 -0.5 2.0
Alcohol usually taken with meals 1.8 3.0 9.1 3.0 1.9 2.1 -0.2 -0.3 1.7 -0.4 0.3 1.7 -0.3 2.7 -2.2
Nervous feelings 0.8 1.5 3.5 0.2 -1.8 -1.8 1.1 0.4 0.6 0.2 1.4 -1.9 -1.3 -0.6 1.7
Frequency of tenseness / restlessness in last 2 weeks 0.8 1.2 4.7 1.1 -0.9 -1.1 1.2 2.2 -0.6 1.1 0.8 -0.4 0.4 -0.5 1.4
Hearing difficulty/problems with background noise 0.6 1.0 3.2 -0.5 -1.8 -1.4 -0.2 0.2 0.1 -1.1 0.7 -0.5 -1.5 -0.3 1.2
Hair/balding pattern: Pattern 2 0.4 0.5 1.9 -1.4 -0.9 -0.8 -0.8 0.8 -0.6 -0.3 -0.1 0.1 -0.6 -0.1 0.7
Had menopause 0.5 0.6 2.0 -0.4 -0.4 -0.5 0.3 -1.0 0.8 1.4 0.8 -1.0 0.7 0.4 0.8
Had other major operations 0.3 0.4 1.7 -0.3 0.3 0.2 0.6 -1.1 1.3 0.1 0.6 -0.6 -0.2 0.5 0.1
Forced vital capacity (FVC) 1.3 5.2 17.3 0.5 4.2 3.5 -0.5 -2.6 0.9 0.3 -0.7 2.3 1.9 1.4 -3.6
Heel bone mineral density (BMD) T-score, automated (right) 1.9 4.3 8.4 -2.4 -2.9 -2.8 -1.4 2.0 -1.3 -0.5 -1.4 -1.2 -2.8 -1.9 2.5
Ever unenthusiastic/disinterested for a whole week 0.6 0.7 3.9 0.7 0.4 0.4 -0.6 2.0 0.2 1.3 -0.4 -0.1 0.8 0.8 -0.2
Qualifications: None of the above 1.0 2.1 9.1 -3.0 -0.9 -0.7 -0.1 -0.2 -1.2 1.7 0.8 -2.6 0.9 -1.1 0.9
Financial difficulties in last 2 years 0.8 1.1 6.2 0.2 -0.4 -0.7 -0.9 1.4 0.4 2.5 -0.2 -0.7 1.4 0.5 1.0
Mouth/teeth dental problems 0.4 0.6 1.4 0.8 -0.5 0.4 -1.1 -1.2 0.7 -0.1 -0.8 0.1 -0.8 1.0 -0.7
Heart attack 0.4 0.5 2.2 0.5 0.5 -0.0 0.9 -0.0 -0.0 1.1 1.5 0.3 1.2 0.4 0.2
Allergy 0.2 0.5 3.3 -1.8 -0.1 -0.2 -1.1 0.5 -0.0 1.0 -0.3 0.5 0.1 0.2 0.3
Pain all over the body in last month 0.8 0.8 1.7 0.3 -1.1 -1.3 0.3 -1.1 -0.4 0.9 0.4 -1.1 0.2 -1.2 1.2
Diabetes (self-reported) 0.7 1.0 2.2 -1.3 -1.1 -0.9 -0.6 0.6 -1.4 0.7 -0.7 -1.5 -0.3 -1.3 0.8
Hayfever/allergic rhinitis (self-reported) 0.8 1.1 4.7 -0.1 -0.5 -0.7 -1.8 -1.1 2.2 0.4 -1.1 -0.3 -0.2 1.1 0.8
Medication: Ramipril 0.8 1.1 4.2 0.8 1.0 1.2 -0.7 -1.4 -0.2 2.0 -0.2 -0.2 1.2 0.4 -1.1
Medication: Simvastatin 0.8 1.2 4.5 -0.2 1.1 0.7 -1.2 -0.9 -0.5 1.9 -1.4 -0.6 2.1 0.3 -0.4
Fluid intelligence score 0.3 0.7 4.1 2.0 0.6 0.4 0.2 0.8 0.7 -1.0 -0.3 1.2 -0.6 -0.0 -0.4
Illnesses of siblings 2.4 3.4 10.9 -1.2 -1.3 -1.2 -0.5 0.8 -2.7 -3.3 -1.7 -0.3 -2.5 -2.6 1.1
Neuroticism score 1.3 2.8 8.6 -0.7 -1.8 -2.0 0.3 1.8 -1.7 1.3 -0.1 -2.9 -0.1 -2.3 2.0
Weight 0.3 1.5 7.6 0.2 0.6 0.3 0.2 -0.5 1.8 2.8 0.6 -0.4 2.1 1.2 -0.0
Impedance of arm (right) 0.8 3.7 8.8 -1.3 -2.3 -2.0 0.1 1.4 -2.7 -2.1 -1.2 0.0 -3.0 -2.7 1.5
Arm fat percentage (right) 0.7 2.9 9.6 -0.7 -2.0 -2.3 0.7 1.3 0.3 3.1 1.3 -1.9 1.0 -0.5 2.5
Trunk fat-free mass 0.5 2.9 6.5 0.4 2.5 2.2 -0.8 -1.2 2.5 1.1 -0.5 0.7 1.8 2.2 -2.2
Hip circumference 1.5 6.4 18.7 -0.8 -3.5 -4.0 1.2 1.5 0.3 3.4 1.9 -3.0 0.3 -0.6 4.3
Time employed in main current job 0.4 0.5 2.4 0.7 0.1 0.2 0.7 -0.5 -0.6 -1.6 0.3 0.4 -1.2 -0.6 -0.3
Alcohol intake versus 10 years previously 0.6 0.9 4.4 -1.2 -0.8 -0.1 0.8 1.1 -1.3 -0.2 0.5 -0.7 -0.4 -2.1 0.0
Father’s age at death 0.3 0.4 1.6 0.9 -0.1 -0.1 1.2 0.5 0.5 -0.8 0.9 0.0 -0.8 -0.2 -0.0
Worrier / anxious feelings 0.7 1.4 4.9 -1.3 -1.7 -1.4 0.0 1.1 -0.0 -0.2 0.2 -2.2 -1.1 -0.9 1.3
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.4 1.3 1.1 0.7 0.7 0.3 -0.9 -0.5 0.8 0.5 0.1 0.8 -0.2 -0.7
Falls in the last year 0.4 0.5 1.7 0.3 -0.9 -0.9 0.1 -1.1 1.3 0.3 0.6 0.8 -0.0 -0.2 0.9
Hair/balding pattern: Pattern 3 1.8 2.6 7.1 2.7 1.2 1.0 1.1 -1.0 1.4 2.1 0.8 2.0 1.8 2.1 -1.0
Number of live births 0.4 0.6 2.0 -1.0 -1.1 -0.6 0.3 1.4 -0.1 0.4 0.6 -1.1 -0.2 -0.5 0.6
Forced expiratory volume in 1-second (FEV1) 1.8 6.2 18.3 1.5 4.3 3.9 0.7 -2.1 1.5 0.0 0.3 3.0 2.1 1.8 -3.9
Pulse rate 2.1 3.6 13.2 1.4 2.0 1.9 0.9 -1.8 1.2 2.5 1.6 0.1 3.6 1.9 -1.6
Happiness 2.0 2.5 11.4 1.2 -0.9 -1.2 -0.0 1.8 -0.8 3.4 0.1 -1.5 2.4 0.2 1.6
Noisy workplace 0.5 0.6 2.1 -1.0 0.3 0.3 1.4 -0.7 -0.9 -0.2 1.4 -0.1 0.3 -1.0 -0.3
Qualifications: A levels/AS levels or equivalent 0.3 0.8 2.7 1.6 -0.4 0.0 -0.3 0.4 0.9 -1.4 -0.6 0.4 -1.6 0.3 -0.3
Serious illness, injury or assault of a close relative in last 2 years 0.5 0.6 2.4 0.8 0.2 0.6 0.5 0.2 1.4 0.1 0.4 1.5 0.6 0.9 -0.7
Mouth/teeth dental problems: Dentures 0.8 1.4 7.3 -2.7 0.5 -0.5 -0.1 -0.2 1.4 1.7 1.0 -0.3 1.7 0.4 0.7
Asthma 0.2 0.4 1.5 1.2 -0.8 -0.5 0.2 0.4 -0.3 0.5 -0.5 -0.7 0.3 -0.7 0.6
Medication: Ibuprofen (e.g. Nurofen) 1.3 1.6 3.8 -1.2 -1.8 -2.0 0.2 0.9 1.1 -0.2 1.3 -1.4 -1.4 -0.2 1.9
Medication: Cholesterol lowering 0.4 0.5 1.7 0.4 0.9 0.7 -0.6 -0.5 -0.6 1.1 -0.9 -0.3 1.3 0.0 -0.7
Depression (self-reported) 0.7 0.8 4.7 -0.3 0.7 0.1 0.2 0.8 0.3 2.2 0.4 -1.3 1.2 0.5 0.1
Medication: Lansoprazole 0.7 0.8 4.1 -0.4 0.1 -0.1 1.3 -0.7 0.4 0.7 2.0 -0.8 1.2 -0.0 0.3
Prospective memory result 1.2 1.4 2.8 -0.4 -1.6 -1.5 1.4 1.4 -0.8 -0.0 0.9 -1.1 -1.2 -1.2 1.7
Lung cancer (father) 2.1 2.5 6.1 1.3 1.8 1.9 1.3 -0.4 0.7 1.2 1.4 1.5 2.5 1.8 -2.0
Illnesses of mother 0.5 0.6 1.4 -1.0 0.3 0.1 -1.2 -0.4 0.3 1.1 -0.7 -1.0 1.2 0.4 -0.0
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 7.9 21.7 1.3 4.7 4.4 -0.1 -2.1 1.7 -0.2 -0.5 3.7 2.1 2.5 -4.4
Pulse wave Arterial Stiffness index 1.2 1.4 4.1 -0.9 -1.5 -1.9 0.0 0.9 -0.6 1.8 -0.4 -0.1 1.1 -0.5 2.0
Impedance of arm (left) 0.9 4.2 9.2 -1.9 -2.3 -2.1 0.3 1.0 -3.0 -2.2 -1.2 0.5 -2.8 -3.0 1.8
Arm fat mass (right) 0.5 2.1 10.7 -0.2 -0.8 -1.2 0.9 0.5 1.1 3.3 1.6 -1.5 1.6 0.4 1.5
Trunk predicted mass 0.5 2.8 6.2 0.3 2.5 2.1 -0.9 -1.2 2.5 1.1 -0.6 0.7 1.7 2.2 -2.1
Standing height 0.4 3.5 9.8 0.3 2.9 2.9 -0.3 -1.8 -0.1 -0.7 -1.9 2.8 0.7 0.1 -3.1
Length of working week for main job 1.5 1.7 3.6 0.6 1.9 1.7 -0.9 -0.2 1.0 0.8 -1.1 1.2 1.6 1.9 -1.5
Exposure to tobacco smoke at home 0.5 0.5 4.3 0.3 0.4 0.4 0.7 -0.0 -2.1 -0.0 -0.3 0.2 0.2 -0.9 -0.3
Breastfed as a baby 4.7 5.8 13.7 3.7 2.2 2.5 1.5 -1.3 3.3 -0.6 1.3 3.1 0.6 3.4 -2.6
Tense / ‘highly strung’ 0.3 0.5 2.2 -0.7 0.3 0.1 0.9 -0.6 -0.5 -0.3 1.0 -1.5 0.3 -0.7 -0.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.4 1.4 -1.0 -0.5 -0.5 0.2 0.6 0.5 -0.7 0.9 -0.5 -1.2 0.4 0.4
Hair/balding pattern: Pattern 4 0.6 1.4 7.1 2.7 0.9 0.5 1.4 0.8 -0.2 1.4 -0.1 0.7 2.0 -0.6 -0.2
Birth weight of first child 0.7 1.2 4.8 0.3 0.2 -0.0 -0.5 -0.1 0.7 1.7 -0.6 2.2 1.9 1.5 0.3
Peak expiratory flow (PEF) 0.6 1.4 4.5 0.3 2.1 2.0 0.9 0.1 -0.1 -0.8 0.1 1.7 0.4 -0.1 -2.0
Pulse wave reflection index 0.9 1.1 5.9 2.4 0.0 0.0 0.8 0.3 0.3 0.7 -0.2 2.4 0.7 0.4 0.0
Ever highly irritable/argumentative for 2 days 2.0 2.4 8.4 0.7 -0.2 -0.4 1.8 2.4 -1.0 2.9 1.4 -0.7 2.6 -0.2 0.6
Loud music exposure frequency 2.3 2.5 8.1 0.4 -2.4 -2.7 0.0 0.9 -1.8 1.1 -0.1 -0.2 -0.1 -1.7 2.8
Qualifications: O levels/GCSEs or equivalent 0.8 1.3 5.9 1.1 1.0 0.9 -0.6 -0.4 0.3 -1.2 -1.5 2.4 -0.5 0.6 -1.1
Mouth/teeth dental problems: Bleeding gums 0.4 0.5 2.3 0.5 0.9 0.6 0.3 0.5 -1.5 0.3 -0.4 -0.1 1.3 -0.5 -0.5
Blood clot in the leg (DVT) 0.8 1.1 6.8 -0.2 -0.6 -0.4 1.3 2.6 -0.6 0.3 0.6 -1.3 -0.7 -1.1 0.1
Medication: Paracetamol 0.7 1.1 4.0 -2.0 -0.7 -1.1 -0.6 -0.2 -0.6 1.2 -0.6 -1.2 0.4 -1.2 1.2
Headache pain in last month 0.9 1.6 6.3 -1.0 -1.9 -2.3 -0.7 0.4 1.2 0.6 -0.4 -0.3 -0.5 0.4 2.5
Medication for cholesterol, blood pressure or diabetes 0.9 1.4 7.5 -1.1 -0.8 -0.7 -0.0 0.6 0.4 -2.7 -0.1 0.6 -2.3 -0.4 0.8
Glaucoma (self-reported) 0.9 1.0 4.0 -1.9 -0.3 -0.1 -0.9 -0.8 1.1 -1.4 -0.4 -0.1 -2.0 0.2 -0.2
Gout (self-reported) 0.4 0.6 3.5 0.6 -0.5 -0.4 -0.8 0.9 -0.4 1.9 -0.5 -0.5 0.6 0.7 0.3
Hypothyroidism/myxoedema (self-reported) 0.6 1.3 2.6 0.1 -1.4 -1.4 1.6 0.8 -1.0 1.2 1.0 -0.6 -0.0 -1.2 1.6
Medication: Amlodipine 1.2 1.6 3.9 1.2 1.9 2.0 0.7 -1.0 1.3 -0.2 1.5 0.2 0.4 1.1 -1.9
Medication: Ventolin 100micrograms inhaler 0.5 0.6 2.3 0.2 -0.6 -0.8 0.6 -1.5 0.4 -1.0 0.5 0.3 -0.9 -0.9 0.8
Birth weight 1.5 3.2 7.1 -1.0 2.4 2.1 -1.4 -2.7 -0.9 0.3 -1.9 1.8 2.5 0.4 -2.0
Chronic bronchitis/emphysema (mother) 0.5 0.6 1.7 -0.2 -0.7 -0.6 -1.0 -0.3 -0.9 1.3 -0.9 -0.9 0.5 -0.2 0.9
High blood pressure (siblings) 2.2 3.1 7.9 1.9 1.5 1.6 0.4 -0.9 2.6 2.1 1.4 0.8 2.0 2.8 -1.6
Forced vital capacity (FVC), Best measure 2.2 7.9 23.4 0.8 4.8 4.4 -0.8 -2.2 1.0 -0.2 -1.3 3.7 2.2 2.0 -4.5
Body fat percentage 0.8 3.3 11.1 -0.5 -2.2 -2.6 1.1 1.0 -0.1 3.3 1.5 -1.5 1.1 -0.7 2.8
Leg fat percentage (right) 0.8 2.9 13.1 0.3 -1.7 -2.2 0.7 0.7 1.1 3.6 1.4 -0.6 1.8 0.8 2.5
Arm fat-free mass (right) 0.5 2.8 6.5 0.4 2.3 2.0 -0.3 -1.4 2.0 2.1 0.2 0.5 2.5 1.9 -1.8
Exposure to tobacco smoke outside home 0.5 0.7 2.3 -1.4 -0.6 -0.2 0.7 -0.1 -1.0 -0.6 0.8 -0.5 -0.8 -1.5 0.3
Comparative body size at age 10 0.6 1.8 6.9 -0.3 1.2 1.4 -1.1 -0.6 2.2 0.7 0.4 -0.8 1.3 2.6 -1.3
Number of full brothers 0.4 0.4 2.5 -0.3 -0.0 0.1 0.7 0.0 1.6 0.5 1.1 0.3 0.2 0.8 -0.1
Worry too long after embarrassment 1.0 1.6 6.9 0.4 -1.3 -0.9 0.7 2.1 -0.3 1.9 0.8 -2.6 0.0 -0.5 0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.4 1.9 0.0 0.4 0.3 -1.4 -0.1 1.0 -0.1 -0.7 -0.0 -0.8 0.8 -0.4
Wheeze or whistling in the chest in last year 0.8 1.4 4.8 1.8 -0.6 -0.8 0.8 0.5 0.6 2.2 1.1 -0.2 2.0 0.2 1.1
Number of children fathered 1.1 1.2 4.9 0.8 0.3 0.4 -1.2 0.2 2.2 -0.8 -0.8 1.8 -0.3 1.7 -0.3
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.5 1.7 -0.9 0.8 0.3 0.2 -0.8 -1.3 0.6 -0.1 -0.6 0.8 -1.0 -0.2
Age at first live birth 0.7 1.3 6.8 2.6 0.9 1.2 0.4 -0.9 -0.4 -1.4 -0.7 0.4 -0.8 -0.3 -1.4
Pulse wave peak to peak time 1.1 1.3 3.9 0.8 1.6 1.9 0.0 -0.9 0.5 -1.7 0.3 0.2 -1.1 0.5 -2.0
Health satisfaction 0.5 0.7 2.5 0.4 0.2 -0.2 1.2 0.1 -0.4 1.4 1.6 -1.1 1.0 -0.1 0.2
Shortness of breath walking on level ground 1.4 1.7 6.5 1.6 -0.2 -0.9 2.0 0.9 1.4 1.2 2.5 -0.4 0.7 0.8 1.1
Qualifications: College or University degree 1.1 3.6 21.2 4.6 -0.1 0.5 0.9 0.0 -0.2 -2.5 -0.6 2.9 -2.3 0.3 -0.7
Eye problems/disorders: None of the above 0.5 0.6 1.2 0.5 -1.0 -0.5 0.5 1.1 -1.1 -0.3 0.4 -0.7 -0.8 -1.1 0.6
Mouth/teeth dental problems: Loose teeth 0.5 0.6 4.2 0.6 -0.4 0.1 0.5 2.1 -0.3 1.2 0.4 -0.7 0.6 -0.4 0.0
Emphysema/chronic bronchitis 0.4 0.4 1.4 -0.3 1.0 0.8 0.4 -0.7 -0.3 -0.5 0.5 -1.2 0.3 -0.7 -0.5
Medication for pain relief, constipation, heartburn 1.3 2.2 7.4 2.7 1.3 2.0 1.3 -0.6 -0.5 -1.1 0.8 2.1 -0.2 0.5 -2.2
Neck or shoulder pain in last month 0.2 0.2 1.2 -0.4 -0.1 -0.2 -0.0 0.0 1.1 0.2 0.8 -0.4 -0.2 0.8 0.1
Medication: Blood pressure 1.3 2.3 10.3 1.6 1.2 1.1 -1.0 -0.7 0.7 3.2 -0.6 -0.2 2.5 1.5 -1.2
Angina (self-reported) 0.5 0.6 2.0 1.1 0.1 -0.3 -0.4 0.3 -0.4 1.4 -0.6 1.4 1.1 0.2 0.3
Migraine (self-reported) 2.8 3.5 9.8 -0.1 -3.1 -3.1 1.7 0.9 0.3 0.5 2.1 -1.1 -1.6 -1.2 3.0
Medication: Ibuprofen 1.0 1.2 3.4 -1.1 -1.4 -1.5 -0.2 0.7 1.8 -0.1 1.0 -0.4 -0.9 0.7 1.5
Medication: Allopurinol 0.8 1.1 3.0 -0.1 -0.9 -1.0 -1.3 1.3 -1.0 1.7 -1.0 -1.1 0.2 -0.3 1.0
Medication: Omeprazole 0.6 0.7 1.9 -1.1 -1.0 -1.4 -0.1 1.0 0.7 0.0 -0.3 0.0 -0.2 -0.6 1.4
Medication: Seretide 50 evohaler 0.4 0.4 1.9 -0.8 -0.7 -0.5 -0.5 -0.8 -0.1 -0.6 0.2 -1.4 -0.7 -0.2 0.5
Mean time to correctly identify matches 1.7 3.3 8.0 -2.8 -2.0 -1.9 -1.5 1.2 -2.0 -0.9 -1.1 -2.0 -1.6 -1.9 1.8
Heart disease (mother) 0.6 0.7 2.9 0.5 0.4 0.7 1.0 0.6 0.0 -1.3 0.6 1.7 -0.7 -0.5 -0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.4 -0.5 0.2 0.1 1.0 1.0 -1.1 0.9 0.4 -1.0 0.2 -1.2 -0.1
Whole body fat mass 0.5 2.1 11.3 -0.4 -1.2 -1.6 0.9 0.4 0.7 3.4 1.3 -1.3 1.6 -0.1 1.8
Leg fat mass (right) 0.6 2.3 14.2 0.0 -0.7 -1.2 0.5 0.1 1.3 3.8 1.1 -0.9 2.3 0.8 1.4
Arm predicted mass (right) 0.5 2.7 6.6 0.5 2.4 2.0 -0.1 -1.4 1.7 2.0 0.3 0.3 2.6 1.7 -1.8
Pulse rate, automated reading 2.3 7.6 24.4 2.7 3.2 3.3 2.0 -1.2 1.3 3.7 2.0 0.5 4.9 2.1 -2.9
Alcohol intake frequency. 4.4 10.2 24.0 -4.1 -4.9 -4.6 -0.9 3.0 -0.3 -0.2 0.4 -3.7 -3.2 -2.6 4.5
Comparative height size at age 10 0.2 1.2 4.5 -2.1 1.1 1.0 -1.1 -0.7 -0.0 1.0 -1.4 0.4 1.2 -0.3 -1.0
Number of full sisters 0.6 0.7 1.5 0.8 1.0 1.2 0.9 1.1 -0.1 0.2 1.0 -0.5 0.8 -0.2 -1.2
Suffer from ‘nerves’ 0.6 1.0 2.0 0.1 0.5 0.1 1.4 1.2 -1.4 0.9 1.0 -1.1 1.3 -1.2 0.1
Overall health rating 0.5 1.1 2.8 -0.1 -1.1 -1.4 0.6 1.0 -0.3 1.7 1.5 -1.2 0.2 -0.6 1.4
Chest pain or discomfort 0.3 0.4 1.6 0.6 0.7 0.6 -1.3 0.4 0.3 0.1 -0.8 0.8 0.5 0.5 -0.4
Had major operations 0.2 0.2 0.7 0.2 -0.0 -0.0 -0.3 0.6 -0.7 0.9 -0.4 -0.9 0.3 -0.5 -0.0
Age at last live birth 0.5 0.8 2.1 1.4 -0.2 -0.1 1.4 -0.1 -0.8 -1.0 1.0 -0.7 -1.1 -0.9 -0.1
Family relationship satisfaction 1.4 1.7 5.0 0.8 -2.0 -2.1 0.8 1.4 -0.7 -0.2 0.6 -1.0 -1.4 -0.6 2.2
Leg pain on walking 0.9 1.1 3.6 -0.6 -1.5 -1.6 -0.8 0.7 0.9 1.3 -0.4 -0.0 0.7 0.4 1.9
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.4 11.6 -3.4 -0.6 -1.4 -2.0 -1.1 1.2 0.8 -0.8 -1.6 1.3 -0.0 1.6
Commuting to job workplace: Car/motor vehicle 0.9 1.1 3.4 0.6 1.1 0.5 -0.4 -0.3 1.5 0.9 -0.1 1.0 1.7 1.8 -0.4
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.6 -0.1 0.6 0.7 0.2 -0.6 -1.6 -1.6 -0.5 -0.7 -1.4 -1.4 -1.0
Medication: Aspirin 1.3 1.7 5.8 2.1 1.4 0.8 0.5 -1.4 0.3 1.5 0.2 0.7 2.4 1.3 -0.6
Supplements: Vitamin C 0.9 1.1 5.5 0.4 0.3 -0.4 -0.2 0.8 -2.3 1.2 -0.9 -0.4 1.5 -1.3 0.5
Knee pain experienced in last month 0.8 1.2 4.9 -2.2 -1.3 -1.5 -0.2 -0.2 1.2 0.1 0.6 -0.6 -0.9 -0.2 1.5
Hypertension (Self-reported) 1.9 5.4 11.8 2.6 2.3 2.0 0.9 -3.0 1.9 3.4 1.8 0.4 3.0 2.5 -2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 0.9 -0.9 -0.8 -0.9 0.2 -0.5 -0.5 -0.5 0.1 -0.1 -0.7 -0.5 0.7
Illnesses of father: Heart disease 0.9 1.2 2.6 1.1 1.4 1.4 1.3 -0.1 1.3 0.3 1.6 -0.5 1.0 1.1 -1.2
Illnesses of siblings: Diabetes 1.1 1.3 4.5 0.7 0.6 0.6 0.7 -0.9 2.1 1.4 1.7 0.4 1.1 1.3 -0.7
Smoking status: Previous 0.7 1.0 2.8 -0.3 1.5 1.7 -0.2 -1.4 -0.8 0.3 -0.1 -0.2 1.5 0.4 -1.5
Forced expiratory volume in 1-second (FEV1), predicted 0.9 1.8 4.2 1.7 2.0 2.0 1.3 -0.7 0.0 -0.3 -0.2 2.1 0.9 0.0 -1.9
Whole body fat-free mass 0.4 2.2 5.1 0.3 2.3 2.0 -0.4 -1.1 2.1 1.4 -0.1 0.2 1.9 1.6 -1.9
Leg fat-free mass (right) 0.3 1.5 3.6 0.3 1.9 1.7 0.6 -1.0 1.4 1.3 0.7 -0.3 1.6 0.6 -1.6
Arm fat percentage (left) 0.7 2.7 10.4 -0.7 -1.8 -2.1 0.8 1.1 0.3 3.2 1.4 -1.6 1.3 -0.4 2.4
Average weekly red wine intake 3.4 5.0 15.6 2.0 3.2 2.5 -1.5 -1.8 2.1 1.1 -0.6 1.5 2.4 4.0 -2.2
Handedness (chirality/laterality): Left-handed 2.2 2.7 10.2 -1.7 -1.3 -1.5 -0.8 -0.1 -2.3 -1.5 -1.5 0.0 -1.5 -3.2 1.5
Mood swings 1.2 2.2 5.8 -1.9 -1.4 -1.9 -0.4 1.2 0.3 1.5 -0.3 -2.4 1.1 -0.6 2.3
Loneliness, isolation 1.2 1.7 4.3 0.3 -1.6 -1.9 0.3 1.9 -1.3 1.5 0.5 -0.7 0.0 -1.1 2.1
Long-standing illness, disability or infirmity 0.9 1.3 6.5 0.6 0.1 0.2 1.0 0.1 -1.7 2.5 0.9 -0.7 1.5 -1.2 -0.1
Ever had bowel cancer screening 0.9 1.0 3.4 -0.4 -1.4 -1.7 -0.3 -0.0 -0.6 1.2 0.1 -0.9 0.5 -0.7 1.8
Diabetes diagnosed by doctor 0.7 1.1 2.6 -1.6 -1.0 -0.8 -0.9 0.4 -1.3 0.7 -1.3 -0.8 -0.3 -1.6 0.8
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 2.4 0.2 0.5 0.2 -0.6 0.9 0.6 1.4 -0.1 1.5 1.2 1.3 -0.1
Friendships satisfaction 0.8 1.0 2.6 -0.0 -1.1 -1.6 0.8 0.6 0.1 -0.0 1.3 -1.4 -1.1 -0.5 1.4
Qualifications: nursing, teaching 0.2 0.4 1.5 -0.1 -0.1 -0.3 -0.6 0.1 -0.6 -1.2 -1.0 -0.2 -0.8 -0.5 0.0
Commuting to job workplace: Walk 0.5 0.5 1.5 0.2 -0.5 -0.5 -0.4 1.2 -0.4 1.2 -0.4 -1.1 0.6 0.3 0.6
Eye problems/disorders: Cataract 0.4 0.5 2.1 -0.6 -0.1 -0.2 -0.7 -0.7 1.5 -0.1 -0.6 0.7 -0.6 1.0 0.1
Mouth/teeth dental problems: Mouth ulcers 0.6 1.0 2.7 -1.4 -1.1 -1.1 -0.6 0.3 0.5 -1.5 -0.5 -0.4 -1.7 0.0 1.0
Medication for cholesterol 0.5 0.8 4.5 0.0 -0.9 -0.5 -0.4 2.1 0.2 -0.9 -0.9 -0.7 -1.0 -0.4 0.4
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.6 -0.4 -0.5 -0.5 0.4 -0.8 0.3 0.3 0.8 -0.8 0.5 -0.1 0.5
Back pain experienced in last month 0.2 0.3 0.9 -0.2 -0.4 -0.5 0.9 -0.1 0.2 -0.6 0.9 -0.4 -0.8 -0.1 0.3
Mineral and other dietary supplements 1.1 1.5 4.7 1.5 0.4 0.5 2.2 2.1 -1.2 -0.2 1.2 1.2 0.1 -1.2 -0.5
Breast cancer (self-reported) 1.3 1.5 5.3 0.6 0.8 0.3 -0.7 -1.9 2.3 1.6 0.2 -0.2 1.4 1.8 -0.0
Asthma (self-reported) 0.2 0.3 1.0 0.8 -0.7 -0.4 -0.1 0.1 -0.2 0.7 -0.5 -1.0 0.5 -0.4 0.5
Osteoporosis (self-reported) 0.1 0.2 0.6 0.8 -0.0 0.3 -0.1 -0.5 0.5 -0.5 0.4 0.2 0.2 0.4 -0.4
Osteoarthritis (self-reported) 1.7 2.2 10.0 -3.2 -1.2 -1.6 -1.7 -0.4 0.0 0.6 -0.3 -2.6 0.1 -0.1 1.6
Medication: Aspirin 1.2 1.5 5.4 1.9 1.2 0.6 0.2 -1.3 0.7 1.7 0.1 0.8 2.3 1.4 -0.2
Medication: Gliclazide 1.6 1.8 5.1 -2.0 -1.4 -1.1 -2.3 1.2 -0.6 0.6 -1.9 -1.1 -0.7 -0.9 1.0
Illnesses of father: None of the above (group 1) 0.3 0.4 2.9 0.1 0.0 0.1 -0.5 -0.6 -0.2 -0.3 -0.4 1.7 0.6 0.7 -0.2
Smoking status: Current 1.3 2.0 4.5 2.1 1.7 1.5 1.1 1.1 1.0 2.0 1.3 1.1 1.6 0.8 -1.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 3.0 6.4 12.1 2.5 3.5 3.3 1.9 -0.6 3.0 0.7 2.5 2.0 2.4 2.9 -3.2
Whole body water mass 0.4 2.2 5.0 0.4 2.2 1.9 -0.4 -1.0 2.0 1.5 -0.1 0.2 2.0 1.5 -1.8
Leg predicted mass (right) 0.3 1.6 3.7 0.3 1.9 1.8 0.5 -1.0 1.5 1.3 0.7 -0.3 1.7 0.7 -1.7
Arm fat mass (left) 0.5 2.0 10.6 -0.4 -0.8 -1.2 0.7 0.6 1.1 3.3 1.3 -1.4 1.7 0.3 1.6
Number of self-reported non-cancer illnesses 0.3 0.6 3.1 0.4 -0.2 -0.4 0.7 -0.0 -0.9 1.8 0.1 0.1 1.0 -0.9 0.3
Average weekly champagne plus white wine intake 0.7 1.0 5.0 2.2 1.1 1.5 0.8 -0.7 -0.3 -0.3 0.1 0.1 -0.1 0.1 -1.5
Miserableness 0.8 1.4 4.0 -0.7 -0.9 -1.1 -0.1 1.4 -2.0 0.3 -0.9 -1.8 -0.1 -1.5 1.3
Guilty feelings 1.4 2.1 8.1 0.5 -1.6 -1.8 0.4 0.8 -0.7 2.4 0.7 -2.9 0.4 -0.6 1.8
Wears glasses or contact lenses 1.5 1.8 7.3 -1.1 -1.1 -1.2 -1.6 1.4 2.7 0.9 -0.3 -0.6 -0.2 1.8 1.1
Ever taken oral contraceptive pill 1.7 1.8 9.4 3.1 1.4 1.3 2.0 0.1 -0.4 -0.4 1.0 1.2 0.1 -0.3 -1.4
Hearing aid user 0.5 0.6 2.8 0.1 -0.2 -0.3 -1.7 0.5 0.4 0.9 -1.3 0.2 0.7 0.7 0.2
Mother’s age at death 1.1 1.4 5.2 1.0 1.0 0.9 -1.2 -0.2 0.8 -1.4 -1.6 2.3 -0.6 0.8 -1.1
Financial situation satisfaction 0.6 0.8 3.6 0.4 -0.7 -1.0 -0.5 1.1 0.5 1.9 -0.4 0.3 0.3 0.6 1.1
Tinnitus: Yes, now most or all of the time 0.3 0.4 1.3 0.9 -0.4 -0.1 -0.2 -1.1 0.9 0.8 0.5 -0.3 0.0 0.7 0.1
Commuting to job workplace: Public transport 0.9 1.0 2.0 1.2 -1.0 -1.2 1.0 0.8 -1.4 -0.1 0.5 -0.3 -1.1 -1.4 1.1
Eye problems/disorders: Glaucoma 1.1 1.4 5.4 -2.3 -0.7 -0.5 -1.0 -1.0 0.9 -1.4 -0.6 -0.5 -2.2 0.1 0.2
Medication: Blood pressure 2.4 4.5 12.9 1.7 2.6 2.5 1.0 -3.6 1.8 1.4 1.7 1.6 1.8 2.1 -2.5
Pain type(s) experienced in last month: Hip pain 0.6 0.8 1.5 -1.0 -0.8 -1.0 -1.1 1.0 1.0 0.8 -1.2 0.4 0.2 0.2 1.0
Supplements: Fish oil (including cod liver oil) 0.3 0.3 1.8 -0.8 0.3 0.3 -0.8 -1.3 0.5 -0.3 -0.3 -0.0 0.3 0.6 -0.2
High cholesterol (Self-reported) 0.4 0.8 2.4 -1.0 0.1 0.0 -0.2 -1.3 -1.6 -0.2 -0.4 -1.1 0.1 -1.6 0.1
Medication: Bendroflumethiazide 1.3 1.9 4.1 1.6 1.5 1.4 -0.6 -1.3 2.0 1.5 0.3 0.1 1.3 2.0 -1.4
Medication: Paracetamol 0.4 0.7 2.2 -1.5 -0.7 -1.2 -0.5 0.1 0.3 1.1 -0.2 -0.0 0.6 -0.4 1.4
Medication: Lisinopril 0.9 1.1 2.8 1.0 0.8 0.8 1.3 -0.8 0.4 1.4 1.7 0.8 1.6 0.7 -0.9
Medication: Atorvastatin 0.8 1.0 5.0 -1.0 -0.7 -0.3 0.7 0.3 0.0 -1.4 1.2 -0.6 -2.2 -0.8 0.1
Illnesses of father: High blood pressure 0.3 0.4 1.7 0.3 0.4 0.2 0.2 -1.1 -0.1 1.0 0.1 -0.3 1.3 0.0 -0.1
Alcohol drinker status: Never 2.0 2.4 6.5 -0.9 -2.0 -1.8 0.8 2.5 -1.0 -0.3 1.6 -2.0 -1.0 -1.6 1.8
Ever smoked 0.5 0.8 2.7 -1.2 1.1 0.7 -0.5 0.5 -1.6 0.6 -0.7 -0.8 0.8 -0.7 -0.6
Basal metabolic rate 0.3 1.8 4.2 0.3 1.8 1.5 -0.2 -1.0 2.0 1.7 0.1 0.1 1.9 1.4 -1.4
Leg fat percentage (left) 0.9 3.2 15.3 0.5 -1.4 -1.9 1.1 0.3 1.1 3.9 1.9 -0.8 2.2 0.8 2.2
Arm fat-free mass (left) 0.5 2.5 5.5 0.4 2.3 2.0 -0.2 -1.2 1.9 1.9 0.1 0.1 2.4 1.7 -1.8
Number of operations (self-reported) 0.4 0.6 2.0 -0.5 -0.2 -0.5 -1.0 -0.4 1.1 1.4 -0.0 -0.9 0.5 0.9 0.7
Average weekly beer plus cider intake 1.2 1.7 3.3 0.0 -1.6 -1.5 1.5 1.8 -0.7 -0.4 1.5 0.4 -1.4 -1.8 1.5
Irritability 0.3 0.5 1.7 -0.1 0.3 -0.1 -0.0 1.0 -0.8 0.8 -0.7 -0.8 0.7 -1.3 0.1
Risk taking 0.2 0.3 1.0 0.9 -0.2 0.1 -0.7 0.3 0.2 -0.9 -1.0 0.4 -0.6 -0.5 0.1
Ever had prostate specific antigen (PSA) test 1.0 1.2 5.0 -1.1 -1.1 -1.2 0.6 2.2 -1.0 0.2 0.7 -0.4 -0.3 -1.4 1.2
Fractured/broken bones in last 5 years 1.0 1.4 5.7 1.0 1.0 1.0 1.1 -1.2 0.9 0.0 1.1 2.4 1.2 0.8 -1.0
Age started oral contraceptive pill 0.3 0.4 2.2 0.6 0.0 0.3 0.2 0.2 -0.7 0.7 0.6 -1.5 0.2 -0.3 -0.2
Diastolic blood pressure, automated reading 1.5 4.5 14.5 2.5 1.7 1.5 2.8 -0.6 0.0 3.8 2.5 0.1 3.4 1.1 -1.3
Ever depressed for a whole week 0.2 0.3 1.0 -0.7 -0.3 -0.2 0.2 0.7 0.1 0.4 0.8 -1.0 0.3 0.4 0.3
Unable to work because of sickness or disability 0.2 0.2 0.8 -0.5 0.2 -0.4 0.3 0.9 0.6 0.4 0.4 -0.4 0.7 -0.1 0.3
Commuting to job workplace: Cycle 1.6 1.9 5.7 1.6 0.4 0.8 1.8 -0.6 0.6 -1.9 2.4 0.1 -2.2 -0.0 -0.9
Myopia 0.3 0.4 1.2 1.1 -0.3 0.1 -0.2 -1.0 0.8 -0.3 0.0 1.0 -0.9 0.3 0.0
Vascular/heart problems diagnosed by doctor 1.7 4.5 14.7 -2.4 -1.9 -1.5 -0.5 2.5 -1.6 -3.8 -1.2 -0.3 -3.1 -2.2 1.5
Cholesterol lowering medication 0.2 0.3 0.8 -0.2 -0.1 -0.2 0.9 -0.9 0.4 0.0 0.9 0.6 -0.5 -0.2 0.3
Medication: Omeprazole (e.g. Zanprol) 1.1 1.3 3.9 -1.6 -1.4 -2.0 -0.4 1.2 0.7 0.4 -0.7 -0.8 -0.3 -0.6 1.9
Pain experienced in last month 0.8 1.3 2.8 0.9 1.7 1.7 -0.9 -0.7 -0.6 -0.1 -1.3 0.6 1.6 0.7 -1.5
Supplements: Calcium 1.7 1.8 7.4 -1.9 -1.6 -1.4 -1.2 0.0 0.5 -0.8 -0.8 -2.7 -1.5 -0.0 1.3
Basal cell carcinoma (self-reported) 0.3 0.3 1.0 -0.1 -0.5 -0.5 -0.3 0.5 0.2 1.0 -0.0 1.0 0.6 1.0 0.2
Heart attack/myocardial infarction (self-reported) 0.4 0.5 2.0 0.4 0.5 0.0 0.9 -0.1 -0.1 1.0 1.4 0.2 1.1 0.5 0.1
Deep venous thrombosis (DVT) (self-reported) 0.8 1.0 5.9 -0.3 -0.7 -0.5 1.4 2.4 -0.3 0.3 0.7 -1.2 -0.7 -1.1 0.3
Heart disease (siblings) 0.4 0.4 1.3 0.1 0.2 0.3 0.8 -1.1 1.1 0.3 1.1 -0.6 -0.1 0.2 -0.2
Alcohol drinker status: Previous 0.9 1.0 3.4 -1.3 0.1 0.3 -1.8 -0.5 0.4 -1.6 -1.4 -0.5 -1.4 -0.6 -0.3
Pack years of smoking 0.6 0.9 5.9 -0.8 -0.2 -0.5 0.4 0.5 -0.0 0.7 1.7 -2.4 0.1 -0.1 0.5
Impedance of whole body 0.5 2.7 8.7 -0.8 -1.9 -1.7 0.3 0.8 -3.0 -1.5 -1.2 1.0 -1.9 -2.3 1.4
Leg fat mass (left) 0.7 2.5 15.7 0.2 -0.5 -1.0 0.8 -0.0 1.1 4.0 1.4 -1.1 2.5 0.6 1.3
Arm predicted mass (left) 0.4 2.1 4.9 0.3 1.9 1.6 -0.3 -1.0 2.1 2.1 0.3 -0.2 2.2 1.8 -1.3