TWAS hub - BCAR3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0410	0.0190	3.9e-03	0.006	0.017	0.003	0.017	0.001	5.3e-02	3.1e-03	1.1e-01	0.0031	2.0e-01
2	GTEx	Artery Aorta	0.1930	0.0580	2.5e-04	0.051	NA	0.074	NA	0.085	8.9e-04	NA	6.5e-05	NA	1.9e-05
3	GTEx	Artery Tibial	0.1095	0.0462	1.5e-03	0.120	NA	0.114	NA	0.120	1.1e-09	NA	3.1e-09	NA	1.1e-09
4	GTEx	Cells Transformed fibroblasts	0.0820	0.0350	3.8e-03	0.033	NA	0.008	NA	0.018	1.7e-03	NA	7.1e-02	NA	1.5e-02
5	GTEx	Muscle Skeletal	0.0757	0.0315	6.5e-03	0.002	NA	0.018	NA	0.008	2.0e-01	NA	6.4e-03	NA	4.9e-02
6	GTEx	Thyroid	0.0940	0.0380	9.0e-03	0.004	NA	-0.003	NA	-0.002	1.4e-01	NA	7.3e-01	NA	5.7e-01
7	ROSMAP	Brain Pre-frontal Cortex	0.0390	0.0180	1.1e-02	0.016	0.000	0.018	0.014	0.012	2.9e-03	2.8e-01	1.7e-03	0.0055	9.3e-03
8	TCGA	Breast Invasive Carcinoma	0.0237	0.0139	3.4e-03	0.016	0.012	0.006	NA	0.014	2.0e-04	1.4e-03	1.7e-02	NA	6.2e-04
9	TCGA	Cervical Squamous Cell Carcinoma	0.1050	0.0570	8.5e-03	0.007	0.014	0.016	NA	0.007	1.3e-01	6.6e-02	5.1e-02	NA	1.3e-01
10	TCGA	Kidney Renal Clear Cell Carcinoma	0.1169	0.0526	2.4e-05	0.028	0.063	0.074	NA	0.058	3.2e-04	1.2e-07	9.8e-09	NA	3.6e-07
11	TCGA	Brain Lower Grade Glioma	0.0534	0.0254	1.7e-03	0.013	0.022	0.009	NA	0.005	1.2e-02	1.4e-03	3.1e-02	NA	7.1e-02
12	TCGA	Prostate Adenocarcinoma	0.3573	0.0591	0.0e+00	0.300	0.263	0.301	NA	0.304	9.1e-32	2.0e-27	6.8e-32	NA	3.0e-32

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12
Breastfed as a baby	4.7	5.8	13.7	3.7	2.2	2.5	1.5	-1.3	3.3	-0.6	1.3	3.1	0.6	3.4	-2.6
Alcohol intake frequency.	4.4	10.2	24.0	-4.1	-4.9	-4.6	-0.9	3.0	-0.3	-0.2	0.4	-3.7	-3.2	-2.6	4.5
Average weekly red wine intake	3.4	5.0	15.6	2.0	3.2	2.5	-1.5	-1.8	2.1	1.1	-0.6	1.5	2.4	4.0	-2.2
Sensitivity / hurt feelings	3.0	5.1	11.2	-1.9	-3.3	-3.3	-0.6	2.0	-1.7	-0.3	-1.1	-1.9	-2.0	-2.9	3.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	3.0	6.4	12.1	2.5	3.5	3.3	1.9	-0.6	3.0	0.7	2.5	2.0	2.4	2.9	-3.2
Migraine (self-reported)	2.8	3.5	9.8	-0.1	-3.1	-3.1	1.7	0.9	0.3	0.5	2.1	-1.1	-1.6	-1.2	3.0
Reaction Time	2.5	4.8	8.5	-2.9	-2.6	-2.3	-1.2	1.2	-2.3	-2.0	-0.8	-2.1	-2.8	-2.6	2.2
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	7.9	21.7	1.3	4.7	4.4	-0.1	-2.1	1.7	-0.2	-0.5	3.7	2.1	2.5	-4.4
Illnesses of siblings	2.4	3.4	10.9	-1.2	-1.3	-1.2	-0.5	0.8	-2.7	-3.3	-1.7	-0.3	-2.5	-2.6	1.1
Medication: Blood pressure	2.4	4.5	12.9	1.7	2.6	2.5	1.0	-3.6	1.8	1.4	1.7	1.6	1.8	2.1	-2.5
Loud music exposure frequency	2.3	2.5	8.1	0.4	-2.4	-2.7	0.0	0.9	-1.8	1.1	-0.1	-0.2	-0.1	-1.7	2.8
Pulse rate, automated reading	2.3	7.6	24.4	2.7	3.2	3.3	2.0	-1.2	1.3	3.7	2.0	0.5	4.9	2.1	-2.9
Medication: Co-codamol	2.2	2.6	6.7	-1.1	-2.5	-2.6	-0.1	1.5	-0.6	0.8	-0.0	-1.8	-1.0	-1.7	2.6
High blood pressure (siblings)	2.2	3.1	7.9	1.9	1.5	1.6	0.4	-0.9	2.6	2.1	1.4	0.8	2.0	2.8	-1.6
Forced vital capacity (FVC), Best measure	2.2	7.9	23.4	0.8	4.8	4.4	-0.8	-2.2	1.0	-0.2	-1.3	3.7	2.2	2.0	-4.5
Handedness (chirality/laterality): Left-handed	2.2	2.7	10.2	-1.7	-1.3	-1.5	-0.8	-0.1	-2.3	-1.5	-1.5	0.0	-1.5	-3.2	1.5
Pulse rate	2.1	3.6	13.2	1.4	2.0	1.9	0.9	-1.8	1.2	2.5	1.6	0.1	3.6	1.9	-1.6
Lung cancer (father)	2.1	2.5	6.1	1.3	1.8	1.9	1.3	-0.4	0.7	1.2	1.4	1.5	2.5	1.8	-2.0
Waist Hip Ratio (WHR)	2.0	9.0	27.2	2.0	4.9	5.0	-0.1	-2.6	1.7	0.7	0.0	2.1	2.7	2.3	-5.2
Happiness	2.0	2.5	11.4	1.2	-0.9	-1.2	-0.0	1.8	-0.8	3.4	0.1	-1.5	2.4	0.2	1.6
Ever highly irritable/argumentative for 2 days	2.0	2.4	8.4	0.7	-0.2	-0.4	1.8	2.4	-1.0	2.9	1.4	-0.7	2.6	-0.2	0.6
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.4	11.6	-3.4	-0.6	-1.4	-2.0	-1.1	1.2	0.8	-0.8	-1.6	1.3	-0.0	1.6
Alcohol drinker status: Never	2.0	2.4	6.5	-0.9	-2.0	-1.8	0.8	2.5	-1.0	-0.3	1.6	-2.0	-1.0	-1.6	1.8
Heel bone mineral density (BMD) T-score, automated (right)	1.9	4.3	8.4	-2.4	-2.9	-2.8	-1.4	2.0	-1.3	-0.5	-1.4	-1.2	-2.8	-1.9	2.5
Hypertension (Self-reported)	1.9	5.4	11.8	2.6	2.3	2.0	0.9	-3.0	1.9	3.4	1.8	0.4	3.0	2.5	-2.1
Hand grip strength (left)	1.8	4.9	10.2	0.9	3.0	2.2	-1.6	-0.8	2.1	2.1	-1.7	2.5	2.7	3.2	-2.1
Alcohol usually taken with meals	1.8	3.0	9.1	3.0	1.9	2.1	-0.2	-0.3	1.7	-0.4	0.3	1.7	-0.3	2.7	-2.2
Hair/balding pattern: Pattern 3	1.8	2.6	7.1	2.7	1.2	1.0	1.1	-1.0	1.4	2.1	0.8	2.0	1.8	2.1	-1.0
Forced expiratory volume in 1-second (FEV1)	1.8	6.2	18.3	1.5	4.3	3.9	0.7	-2.1	1.5	0.0	0.3	3.0	2.1	1.8	-3.9
LDL Cholesterol	1.7	2.7	7.6	-2.6	-1.4	-1.4	-0.5	-0.0	-0.5	-2.8	-0.4	-0.1	-2.5	-2.4	1.4
Neuroticism	1.7	4.0	8.7	-1.0	-2.4	-2.6	0.8	2.1	-1.5	2.1	0.7	-3.0	0.1	-2.5	2.7
Heel bone mineral density (BMD) T-score, automated (left)	1.7	3.9	8.3	-2.2	-2.7	-2.5	-1.1	2.0	-1.2	-0.7	-1.2	-1.6	-2.9	-2.2	2.0
High blood pressure	1.7	4.7	12.3	2.5	2.1	1.8	0.7	-2.9	1.6	3.5	1.4	0.2	2.9	2.3	-1.9
Mean time to correctly identify matches	1.7	3.3	8.0	-2.8	-2.0	-1.9	-1.5	1.2	-2.0	-0.9	-1.1	-2.0	-1.6	-1.9	1.8
Osteoarthritis (self-reported)	1.7	2.2	10.0	-3.2	-1.2	-1.6	-1.7	-0.4	0.0	0.6	-0.3	-2.6	0.1	-0.1	1.6
Ever taken oral contraceptive pill	1.7	1.8	9.4	3.1	1.4	1.3	2.0	0.1	-0.4	-0.4	1.0	1.2	0.1	-0.3	-1.4
Vascular/heart problems diagnosed by doctor	1.7	4.5	14.7	-2.4	-1.9	-1.5	-0.5	2.5	-1.6	-3.8	-1.2	-0.3	-3.1	-2.2	1.5
Supplements: Calcium	1.7	1.8	7.4	-1.9	-1.6	-1.4	-1.2	0.0	0.5	-0.8	-0.8	-2.7	-1.5	-0.0	1.3
Smoking Status	1.6	3.8	9.8	2.4	2.9	2.6	1.2	-0.2	0.5	2.5	1.2	0.7	3.1	0.8	-2.2
Medication: Gliclazide	1.6	1.8	5.1	-2.0	-1.4	-1.1	-2.3	1.2	-0.6	0.6	-1.9	-1.1	-0.7	-0.9	1.0
Commuting to job workplace: Cycle	1.6	1.9	5.7	1.6	0.4	0.8	1.8	-0.6	0.6	-1.9	2.4	0.1	-2.2	-0.0	-0.9
Depressed Affect (Nagel 2018)	1.5	3.2	9.7	-1.6	-1.1	-1.6	0.0	1.7	-0.6	3.1	0.6	-3.1	1.9	-0.7	2.1
Mean Putamen Volume	1.5	1.7	6.5	-0.1	-1.0	-0.9	-2.0	0.7	2.5	1.5	-0.8	0.3	0.2	1.9	0.8
Systolic Blood Pressure	1.5	7.6	16.4	3.1	3.5	3.1	1.9	-1.7	1.0	3.4	2.5	0.8	4.0	2.9	-3.0
Cardiovascular Disease	1.5	5.0	11.6	2.2	3.0	2.5	0.5	-2.6	1.2	3.0	0.9	1.0	3.4	1.8	-2.4
Hip circumference	1.5	6.4	18.7	-0.8	-3.5	-4.0	1.2	1.5	0.3	3.4	1.9	-3.0	0.3	-0.6	4.3
Length of working week for main job	1.5	1.7	3.6	0.6	1.9	1.7	-0.9	-0.2	1.0	0.8	-1.1	1.2	1.6	1.9	-1.5
Birth weight	1.5	3.2	7.1	-1.0	2.4	2.1	-1.4	-2.7	-0.9	0.3	-1.9	1.8	2.5	0.4	-2.0
Wears glasses or contact lenses	1.5	1.8	7.3	-1.1	-1.1	-1.2	-1.6	1.4	2.7	0.9	-0.3	-0.6	-0.2	1.8	1.1
Diastolic blood pressure, automated reading	1.5	4.5	14.5	2.5	1.7	1.5	2.8	-0.6	0.0	3.8	2.5	0.1	3.4	1.1	-1.3
Medication: Atenolol	1.4	1.8	3.5	1.8	1.8	1.7	-0.1	-0.9	-0.4	1.5	0.1	0.6	1.9	1.4	-1.7
Shortness of breath walking on level ground	1.4	1.7	6.5	1.6	-0.2	-0.9	2.0	0.9	1.4	1.2	2.5	-0.4	0.7	0.8	1.1
Family relationship satisfaction	1.4	1.7	5.0	0.8	-2.0	-2.1	0.8	1.4	-0.7	-0.2	0.6	-1.0	-1.4	-0.6	2.2
Guilty feelings	1.4	2.1	8.1	0.5	-1.6	-1.8	0.4	0.8	-0.7	2.4	0.7	-2.9	0.4	-0.6	1.8
Neuroticism (Nagel 2018)	1.3	3.1	13.4	-0.7	-0.8	-1.2	0.4	1.8	-0.1	3.3	0.9	-3.7	2.0	-0.5	1.6
Blood White Count	1.3	9.3	32.3	0.1	-3.7	-5.2	-0.7	2.3	0.4	5.2	0.2	-1.2	2.0	-0.1	5.7
Hand grip strength (right)	1.3	3.5	7.2	0.6	2.7	2.1	-0.7	-0.8	2.1	2.0	-0.9	2.0	2.2	2.5	-2.1
Supplements: Glucosamine	1.3	1.7	10.9	0.6	0.3	0.2	-1.0	-1.4	3.3	0.3	-0.4	0.1	0.2	2.3	-0.3
Forced vital capacity (FVC)	1.3	5.2	17.3	0.5	4.2	3.5	-0.5	-2.6	0.9	0.3	-0.7	2.3	1.9	1.4	-3.6
Neuroticism score	1.3	2.8	8.6	-0.7	-1.8	-2.0	0.3	1.8	-1.7	1.3	-0.1	-2.9	-0.1	-2.3	2.0
Medication: Ibuprofen (e.g. Nurofen)	1.3	1.6	3.8	-1.2	-1.8	-2.0	0.2	0.9	1.1	-0.2	1.3	-1.4	-1.4	-0.2	1.9
Medication for pain relief, constipation, heartburn	1.3	2.2	7.4	2.7	1.3	2.0	1.3	-0.6	-0.5	-1.1	0.8	2.1	-0.2	0.5	-2.2
Medication: Blood pressure	1.3	2.3	10.3	1.6	1.2	1.1	-1.0	-0.7	0.7	3.2	-0.6	-0.2	2.5	1.5	-1.2
Medication: Aspirin	1.3	1.7	5.8	2.1	1.4	0.8	0.5	-1.4	0.3	1.5	0.2	0.7	2.4	1.3	-0.6
Breast cancer (self-reported)	1.3	1.5	5.3	0.6	0.8	0.3	-0.7	-1.9	2.3	1.6	0.2	-0.2	1.4	1.8	-0.0
Smoking status: Current	1.3	2.0	4.5	2.1	1.7	1.5	1.1	1.1	1.0	2.0	1.3	1.1	1.6	0.8	-1.3
Medication: Bendroflumethiazide	1.3	1.9	4.1	1.6	1.5	1.4	-0.6	-1.3	2.0	1.5	0.3	0.1	1.3	2.0	-1.4
HbA1C	1.2	1.3	2.5	1.6	0.8	1.1	1.3	-0.2	1.6	-0.1	1.4	0.9	-0.3	1.5	-1.4
Prospective memory result	1.2	1.4	2.8	-0.4	-1.6	-1.5	1.4	1.4	-0.8	-0.0	0.9	-1.1	-1.2	-1.2	1.7
Pulse wave Arterial Stiffness index	1.2	1.4	4.1	-0.9	-1.5	-1.9	0.0	0.9	-0.6	1.8	-0.4	-0.1	1.1	-0.5	2.0
Medication: Amlodipine	1.2	1.6	3.9	1.2	1.9	2.0	0.7	-1.0	1.3	-0.2	1.5	0.2	0.4	1.1	-1.9
Mood swings	1.2	2.2	5.8	-1.9	-1.4	-1.9	-0.4	1.2	0.3	1.5	-0.3	-2.4	1.1	-0.6	2.3
Loneliness, isolation	1.2	1.7	4.3	0.3	-1.6	-1.9	0.3	1.9	-1.3	1.5	0.5	-0.7	0.0	-1.1	2.1
Medication: Aspirin	1.2	1.5	5.4	1.9	1.2	0.6	0.2	-1.3	0.7	1.7	0.1	0.8	2.3	1.4	-0.2
Average weekly beer plus cider intake	1.2	1.7	3.3	0.0	-1.6	-1.5	1.5	1.8	-0.7	-0.4	1.5	0.4	-1.4	-1.8	1.5
Lupus	1.1	1.7	6.6	-2.6	-1.3	-1.7	-1.5	-0.7	-0.2	1.0	-1.2	-0.8	-0.3	-0.1	1.6
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	5.5	-1.3	-1.2	-1.5	-1.0	2.3	-0.7	-0.0	-1.0	-0.3	-0.4	-0.8	1.3
High blood pressure (mother)	1.1	1.6	2.9	1.0	1.6	1.5	0.8	-1.1	1.7	-1.0	0.8	1.3	0.3	1.7	-1.4
Number of incorrect matches in round	1.1	1.8	5.3	-1.9	-0.8	-0.8	0.2	-0.8	-2.3	2.2	0.3	-1.4	1.6	-0.5	0.8
Past tobacco smoking	1.1	1.9	6.3	0.1	-2.5	-2.3	0.4	1.0	1.0	-0.7	0.3	0.1	-2.1	-0.5	2.0
Number of children fathered	1.1	1.2	4.9	0.8	0.3	0.4	-1.2	0.2	2.2	-0.8	-0.8	1.8	-0.3	1.7	-0.3
Pulse wave peak to peak time	1.1	1.3	3.9	0.8	1.6	1.9	0.0	-0.9	0.5	-1.7	0.3	0.2	-1.1	0.5	-2.0
Qualifications: College or University degree	1.1	3.6	21.2	4.6	-0.1	0.5	0.9	0.0	-0.2	-2.5	-0.6	2.9	-2.3	0.3	-0.7
Illnesses of siblings: Diabetes	1.1	1.3	4.5	0.7	0.6	0.6	0.7	-0.9	2.1	1.4	1.7	0.4	1.1	1.3	-0.7
Mineral and other dietary supplements	1.1	1.5	4.7	1.5	0.4	0.5	2.2	2.1	-1.2	-0.2	1.2	1.2	0.1	-1.2	-0.5
Mother’s age at death	1.1	1.4	5.2	1.0	1.0	0.9	-1.2	-0.2	0.8	-1.4	-1.6	2.3	-0.6	0.8	-1.1
Eye problems/disorders: Glaucoma	1.1	1.4	5.4	-2.3	-0.7	-0.5	-1.0	-1.0	0.9	-1.4	-0.6	-0.5	-2.2	0.1	0.2
Medication: Omeprazole (e.g. Zanprol)	1.1	1.3	3.9	-1.6	-1.4	-2.0	-0.4	1.2	0.7	0.4	-0.7	-0.8	-0.3	-0.6	1.9
Crohns Disease (2017)	1.0	2.2	7.0	1.4	2.3	2.6	-0.4	-0.9	-0.9	-0.0	-0.8	0.0	1.6	0.7	-2.6
Current tobacco smoking	1.0	1.7	5.3	1.8	0.8	0.6	1.2	1.8	0.9	2.3	1.4	0.8	1.3	0.5	-0.4
Qualifications: None of the above	1.0	2.1	9.1	-3.0	-0.9	-0.7	-0.1	-0.2	-1.2	1.7	0.8	-2.6	0.9	-1.1	0.9
Worry too long after embarrassment	1.0	1.6	6.9	0.4	-1.3	-0.9	0.7	2.1	-0.3	1.9	0.8	-2.6	0.0	-0.5	0.8
Medication: Ibuprofen	1.0	1.2	3.4	-1.1	-1.4	-1.5	-0.2	0.7	1.8	-0.1	1.0	-0.4	-0.9	0.7	1.5
Ever had prostate specific antigen (PSA) test	1.0	1.2	5.0	-1.1	-1.1	-1.2	0.6	2.2	-1.0	0.2	0.7	-0.4	-0.3	-1.4	1.2
Fractured/broken bones in last 5 years	1.0	1.4	5.7	1.0	1.0	1.0	1.1	-1.2	0.9	0.0	1.1	2.4	1.2	0.8	-1.0
Bipolar Disorder (2018)	0.9	1.5	5.6	0.8	-0.5	-0.4	-1.1	0.2	1.9	2.1	-0.5	-0.3	1.0	2.4	0.6
Type 2 Diabetes (T2D) (2012)	0.9	1.0	4.4	-1.1	-1.4	-1.9	0.3	0.2	0.2	0.6	-0.7	-0.1	0.0	0.1	2.1
Systolic blood pressure, automated reading	0.9	2.7	10.9	0.9	0.9	0.8	1.9	-1.0	-0.7	3.3	2.1	-0.6	2.9	0.8	-0.6
Relative age voice broke	0.9	1.4	6.2	-0.4	-1.3	-0.9	1.4	0.8	-0.7	-1.6	1.1	0.1	-2.5	-0.3	0.7
Serious illness, injury or assault to yourself	0.9	1.1	3.3	1.8	-0.3	-0.2	0.4	0.4	1.4	1.6	1.0	0.6	1.1	1.2	0.6
Impedance of arm (left)	0.9	4.2	9.2	-1.9	-2.3	-2.1	0.3	1.0	-3.0	-2.2	-1.2	0.5	-2.8	-3.0	1.8
Pulse wave reflection index	0.9	1.1	5.9	2.4	0.0	0.0	0.8	0.3	0.3	0.7	-0.2	2.4	0.7	0.4	0.0
Headache pain in last month	0.9	1.6	6.3	-1.0	-1.9	-2.3	-0.7	0.4	1.2	0.6	-0.4	-0.3	-0.5	0.4	2.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.4	7.5	-1.1	-0.8	-0.7	-0.0	0.6	0.4	-2.7	-0.1	0.6	-2.3	-0.4	0.8
Glaucoma (self-reported)	0.9	1.0	4.0	-1.9	-0.3	-0.1	-0.9	-0.8	1.1	-1.4	-0.4	-0.1	-2.0	0.2	-0.2
Leg pain on walking	0.9	1.1	3.6	-0.6	-1.5	-1.6	-0.8	0.7	0.9	1.3	-0.4	-0.0	0.7	0.4	1.9
Commuting to job workplace: Car/motor vehicle	0.9	1.1	3.4	0.6	1.1	0.5	-0.4	-0.3	1.5	0.9	-0.1	1.0	1.7	1.8	-0.4
Supplements: Vitamin C	0.9	1.1	5.5	0.4	0.3	-0.4	-0.2	0.8	-2.3	1.2	-0.9	-0.4	1.5	-1.3	0.5
Illnesses of father: Heart disease	0.9	1.2	2.6	1.1	1.4	1.4	1.3	-0.1	1.3	0.3	1.6	-0.5	1.0	1.1	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	0.9	1.8	4.2	1.7	2.0	2.0	1.3	-0.7	0.0	-0.3	-0.2	2.1	0.9	0.0	-1.9
Long-standing illness, disability or infirmity	0.9	1.3	6.5	0.6	0.1	0.2	1.0	0.1	-1.7	2.5	0.9	-0.7	1.5	-1.2	-0.1
Ever had bowel cancer screening	0.9	1.0	3.4	-0.4	-1.4	-1.7	-0.3	-0.0	-0.6	1.2	0.1	-0.9	0.5	-0.7	1.8
Commuting to job workplace: Public transport	0.9	1.0	2.0	1.2	-1.0	-1.2	1.0	0.8	-1.4	-0.1	0.5	-0.3	-1.1	-1.4	1.1
Medication: Lisinopril	0.9	1.1	2.8	1.0	0.8	0.8	1.3	-0.8	0.4	1.4	1.7	0.8	1.6	0.7	-0.9
Leg fat percentage (left)	0.9	3.2	15.3	0.5	-1.4	-1.9	1.1	0.3	1.1	3.9	1.9	-0.8	2.2	0.8	2.2
Alcohol drinker status: Previous	0.9	1.0	3.4	-1.3	0.1	0.3	-1.8	-0.5	0.4	-1.6	-1.4	-0.5	-1.4	-0.6	-0.3
Lung FEV1/FVC ratio	0.8	4.1	13.1	3.2	0.4	0.7	3.6	2.7	1.2	1.5	3.3	0.7	1.2	0.9	-0.6
Frequency of depressed mood in last 2 weeks	0.8	1.1	4.6	0.6	-0.8	-0.8	1.3	2.1	-0.9	-0.2	1.4	0.2	-0.6	-0.9	0.9
Ever had hysterectomy (womb removed)	0.8	0.9	4.0	-2.0	0.4	-0.0	-1.4	-0.5	-0.9	-0.7	-1.4	0.7	0.1	-0.8	0.1
Medication for hormone replacement therapy	0.8	0.9	2.9	-0.8	-1.1	-1.6	-0.2	-0.0	-1.2	1.1	0.1	-0.7	0.6	-0.3	1.7
Trunk fat percentage	0.8	3.3	9.1	-0.9	-2.4	-2.6	1.3	1.0	-0.4	3.0	1.5	-1.6	0.8	-1.1	2.8
Maternal smoking around birth	0.8	1.1	3.8	0.2	-1.1	-1.2	1.3	-1.0	-0.4	1.9	1.2	-0.4	0.8	-0.8	1.3
Taking other prescription medications	0.8	1.2	5.2	0.3	-0.5	-0.6	1.3	0.1	0.4	2.3	1.6	-0.7	1.8	-0.2	0.6
Nervous feelings	0.8	1.5	3.5	0.2	-1.8	-1.8	1.1	0.4	0.6	0.2	1.4	-1.9	-1.3	-0.6	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.2	4.7	1.1	-0.9	-1.1	1.2	2.2	-0.6	1.1	0.8	-0.4	0.4	-0.5	1.4
Financial difficulties in last 2 years	0.8	1.1	6.2	0.2	-0.4	-0.7	-0.9	1.4	0.4	2.5	-0.2	-0.7	1.4	0.5	1.0
Pain all over the body in last month	0.8	0.8	1.7	0.3	-1.1	-1.3	0.3	-1.1	-0.4	0.9	0.4	-1.1	0.2	-1.2	1.2
Hayfever/allergic rhinitis (self-reported)	0.8	1.1	4.7	-0.1	-0.5	-0.7	-1.8	-1.1	2.2	0.4	-1.1	-0.3	-0.2	1.1	0.8
Medication: Ramipril	0.8	1.1	4.2	0.8	1.0	1.2	-0.7	-1.4	-0.2	2.0	-0.2	-0.2	1.2	0.4	-1.1
Medication: Simvastatin	0.8	1.2	4.5	-0.2	1.1	0.7	-1.2	-0.9	-0.5	1.9	-1.4	-0.6	2.1	0.3	-0.4
Impedance of arm (right)	0.8	3.7	8.8	-1.3	-2.3	-2.0	0.1	1.4	-2.7	-2.1	-1.2	0.0	-3.0	-2.7	1.5
Mouth/teeth dental problems: Dentures	0.8	1.4	7.3	-2.7	0.5	-0.5	-0.1	-0.2	1.4	1.7	1.0	-0.3	1.7	0.4	0.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	5.9	1.1	1.0	0.9	-0.6	-0.4	0.3	-1.2	-1.5	2.4	-0.5	0.6	-1.1
Blood clot in the leg (DVT)	0.8	1.1	6.8	-0.2	-0.6	-0.4	1.3	2.6	-0.6	0.3	0.6	-1.3	-0.7	-1.1	0.1
Body fat percentage	0.8	3.3	11.1	-0.5	-2.2	-2.6	1.1	1.0	-0.1	3.3	1.5	-1.5	1.1	-0.7	2.8
Leg fat percentage (right)	0.8	2.9	13.1	0.3	-1.7	-2.2	0.7	0.7	1.1	3.6	1.4	-0.6	1.8	0.8	2.5
Wheeze or whistling in the chest in last year	0.8	1.4	4.8	1.8	-0.6	-0.8	0.8	0.5	0.6	2.2	1.1	-0.2	2.0	0.2	1.1
Medication: Allopurinol	0.8	1.1	3.0	-0.1	-0.9	-1.0	-1.3	1.3	-1.0	1.7	-1.0	-1.1	0.2	-0.3	1.0
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.6	-0.1	0.6	0.7	0.2	-0.6	-1.6	-1.6	-0.5	-0.7	-1.4	-1.4	-1.0
Knee pain experienced in last month	0.8	1.2	4.9	-2.2	-1.3	-1.5	-0.2	-0.2	1.2	0.1	0.6	-0.6	-0.9	-0.2	1.5
Friendships satisfaction	0.8	1.0	2.6	-0.0	-1.1	-1.6	0.8	0.6	0.1	-0.0	1.3	-1.4	-1.1	-0.5	1.4
Miserableness	0.8	1.4	4.0	-0.7	-0.9	-1.1	-0.1	1.4	-2.0	0.3	-0.9	-1.8	-0.1	-1.5	1.3
Medication: Atorvastatin	0.8	1.0	5.0	-1.0	-0.7	-0.3	0.7	0.3	0.0	-1.4	1.2	-0.6	-2.2	-0.8	0.1
Pain experienced in last month	0.8	1.3	2.8	0.9	1.7	1.7	-0.9	-0.7	-0.6	-0.1	-1.3	0.6	1.6	0.7	-1.5
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	5.9	-0.3	-0.7	-0.5	1.4	2.4	-0.3	0.3	0.7	-1.2	-0.7	-1.1	0.3
Bipolar Disorder or Schizophrenia	0.7	1.8	5.5	1.0	0.9	1.2	-1.5	-1.1	2.1	1.2	-1.0	-0.2	1.1	2.3	-1.0
Schizophrenia (2018)	0.7	1.4	3.7	0.6	1.6	1.9	-1.0	-1.6	1.2	-0.0	-0.8	0.0	0.6	1.1	-1.8
Schizophrenia vs Biploar Disorder	0.7	0.9	2.5	-0.8	0.4	0.7	-0.1	-1.0	-1.3	-1.4	-0.5	-0.7	-1.0	-1.6	-0.7
Bipolar Disorder (2011)	0.7	0.7	2.6	0.1	-1.2	-1.1	-0.8	1.6	-0.1	0.8	-0.8	0.5	-0.2	0.5	0.8
Blood Eosinophil Count	0.7	5.7	25.5	5.0	1.9	1.3	1.4	-2.0	1.2	2.2	1.5	2.0	3.2	2.8	-1.1
Hypothyroidism (self reported)	0.7	1.6	4.0	0.5	-1.3	-1.5	1.5	0.7	-0.4	2.0	1.0	-1.7	0.3	-0.7	1.8
Average weekly spirits intake	0.7	0.9	4.7	-0.3	-0.4	-0.7	-1.1	0.5	2.2	0.8	-0.2	0.0	-0.1	1.6	0.5
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.4	-0.4	-1.1	-1.2	0.5	0.9	-0.6	0.6	0.2	-1.6	0.3	-1.5	1.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.8	-0.8	0.6	0.6	-0.9	-1.7	-1.5	1.1	-0.6	-1.0	1.0	-0.1	-0.6
Medication: Metformin	0.7	0.9	4.6	-2.1	-0.5	-0.2	-1.8	0.4	-0.2	0.6	-1.5	-0.0	-0.1	-0.3	0.2
Diabetes (father)	0.7	0.9	2.3	1.1	-0.8	-0.6	1.5	0.9	1.5	0.3	1.5	-0.5	-0.1	0.1	0.7
Severe depression (siblings)	0.7	0.7	2.4	1.0	0.1	0.2	1.1	-0.6	0.4	1.2	1.5	-0.4	0.9	1.1	-0.1
Medication: Levothyroxine sodium	0.7	1.2	2.9	-0.1	-1.6	-1.5	1.7	0.8	-0.8	0.7	1.0	-0.3	-0.7	-1.2	1.4
Diabetes (self-reported)	0.7	1.0	2.2	-1.3	-1.1	-0.9	-0.6	0.6	-1.4	0.7	-0.7	-1.5	-0.3	-1.3	0.8
Arm fat percentage (right)	0.7	2.9	9.6	-0.7	-2.0	-2.3	0.7	1.3	0.3	3.1	1.3	-1.9	1.0	-0.5	2.5
Worrier / anxious feelings	0.7	1.4	4.9	-1.3	-1.7	-1.4	0.0	1.1	-0.0	-0.2	0.2	-2.2	-1.1	-0.9	1.3
Depression (self-reported)	0.7	0.8	4.7	-0.3	0.7	0.1	0.2	0.8	0.3	2.2	0.4	-1.3	1.2	0.5	0.1
Medication: Lansoprazole	0.7	0.8	4.1	-0.4	0.1	-0.1	1.3	-0.7	0.4	0.7	2.0	-0.8	1.2	-0.0	0.3
Birth weight of first child	0.7	1.2	4.8	0.3	0.2	-0.0	-0.5	-0.1	0.7	1.7	-0.6	2.2	1.9	1.5	0.3
Medication: Paracetamol	0.7	1.1	4.0	-2.0	-0.7	-1.1	-0.6	-0.2	-0.6	1.2	-0.6	-1.2	0.4	-1.2	1.2
Age at first live birth	0.7	1.3	6.8	2.6	0.9	1.2	0.4	-0.9	-0.4	-1.4	-0.7	0.4	-0.8	-0.3	-1.4
Smoking status: Previous	0.7	1.0	2.8	-0.3	1.5	1.7	-0.2	-1.4	-0.8	0.3	-0.1	-0.2	1.5	0.4	-1.5
Arm fat percentage (left)	0.7	2.7	10.4	-0.7	-1.8	-2.1	0.8	1.1	0.3	3.2	1.4	-1.6	1.3	-0.4	2.4
Diabetes diagnosed by doctor	0.7	1.1	2.6	-1.6	-1.0	-0.8	-0.9	0.4	-1.3	0.7	-1.3	-0.8	-0.3	-1.6	0.8
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	2.4	0.2	0.5	0.2	-0.6	0.9	0.6	1.4	-0.1	1.5	1.2	1.3	-0.1
Average weekly champagne plus white wine intake	0.7	1.0	5.0	2.2	1.1	1.5	0.8	-0.7	-0.3	-0.3	0.1	0.1	-0.1	0.1	-1.5
Leg fat mass (left)	0.7	2.5	15.7	0.2	-0.5	-1.0	0.8	-0.0	1.1	4.0	1.4	-1.1	2.5	0.6	1.3
Worry (Nagel 2018)	0.6	1.2	5.7	0.3	-0.1	-0.4	0.8	1.5	0.0	1.5	1.1	-2.4	1.0	0.0	0.7
Alzheimer’s Disease (in mother)	0.6	0.8	2.4	1.6	-0.2	-0.6	1.4	-0.1	-0.7	0.9	0.9	1.2	0.4	0.0	0.6
Alzheimer’s Disease (including proxy)	0.6	0.9	2.0	1.4	-0.6	-1.1	0.7	0.7	-0.7	1.4	1.0	-0.1	0.6	0.3	1.4
Irritable Bowel Disease (IBD)	0.6	1.4	3.4	1.0	1.7	1.9	-0.2	-0.9	-1.0	0.7	-0.6	-0.0	1.8	0.5	-1.7
Major Depression (MDD)	0.6	0.8	2.8	-0.7	1.0	0.8	-0.3	-0.3	0.7	1.2	0.1	-0.2	1.7	1.4	-0.5
Body Mass Index (BMI) (2010)	0.6	0.8	2.8	1.6	-0.4	-0.3	1.7	-0.2	0.3	0.9	1.6	-0.2	0.2	-0.3	0.3
Fasting Glucose	0.6	0.7	2.2	-0.5	-1.5	-1.2	0.6	0.2	0.6	0.5	0.1	-0.6	0.3	-0.8	1.5
Primary Biliary Cirrhosis	0.6	0.9	3.5	0.8	0.7	0.7	1.4	0.7	0.5	-1.2	1.0	1.9	-0.3	-0.2	-0.5
Rheumatoid Arthritis	0.6	0.8	2.2	-0.6	-0.4	-0.9	1.5	-1.1	0.0	0.0	1.4	-0.5	-0.1	-1.5	0.7
Blood Platelet Count	0.6	6.9	22.5	2.4	0.3	-0.6	-2.7	-3.9	1.6	4.7	-1.3	0.6	4.1	3.1	1.0
BMI	0.6	3.6	15.3	-0.2	-1.2	-1.8	-0.4	0.1	2.0	3.9	1.3	-2.6	1.9	1.5	2.0
Lung FVC	0.6	3.1	9.2	-0.0	3.0	2.8	-1.1	-1.1	1.0	0.5	-0.7	1.4	2.1	1.7	-2.6
Hearing difficulty/problems: Yes	0.6	0.9	3.9	0.6	-1.4	-0.9	-0.1	-0.1	0.3	-1.4	0.3	1.2	-2.0	-0.0	0.7
Average weekly fortified wine intake	0.6	0.6	1.6	0.6	1.0	0.8	-0.4	-1.2	-1.3	0.7	-0.6	0.8	0.7	0.1	-0.8
Fed-up feelings	0.6	1.1	5.0	-0.3	0.0	-0.6	0.2	1.3	-0.2	2.2	0.8	-1.4	1.6	0.7	0.8
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.6	-0.3	0.2	0.6	-1.1	0.3	-1.9	0.1	-1.5	0.0	0.3	-0.5	-0.5
Qualifications: CSEs or equivalent	0.6	0.8	2.4	0.1	1.0	1.1	-0.4	-0.8	-0.3	0.7	-0.8	1.3	1.5	0.1	-1.0
Body mass index (BMI)	0.6	2.6	10.8	0.0	-0.8	-1.2	0.5	0.5	2.0	3.3	1.8	-1.7	1.8	1.3	1.6
Waist circumference	0.6	2.2	11.1	0.5	-0.6	-0.9	1.0	-0.0	1.5	3.3	1.8	-1.2	1.9	0.9	1.2
Hearing difficulty/problems with background noise	0.6	1.0	3.2	-0.5	-1.8	-1.4	-0.2	0.2	0.1	-1.1	0.7	-0.5	-1.5	-0.3	1.2
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	3.9	0.7	0.4	0.4	-0.6	2.0	0.2	1.3	-0.4	-0.1	0.8	0.8	-0.2
Alcohol intake versus 10 years previously	0.6	0.9	4.4	-1.2	-0.8	-0.1	0.8	1.1	-1.3	-0.2	0.5	-0.7	-0.4	-2.1	0.0
Hair/balding pattern: Pattern 4	0.6	1.4	7.1	2.7	0.9	0.5	1.4	0.8	-0.2	1.4	-0.1	0.7	2.0	-0.6	-0.2
Peak expiratory flow (PEF)	0.6	1.4	4.5	0.3	2.1	2.0	0.9	0.1	-0.1	-0.8	0.1	1.7	0.4	-0.1	-2.0
Hypothyroidism/myxoedema (self-reported)	0.6	1.3	2.6	0.1	-1.4	-1.4	1.6	0.8	-1.0	1.2	1.0	-0.6	-0.0	-1.2	1.6
Comparative body size at age 10	0.6	1.8	6.9	-0.3	1.2	1.4	-1.1	-0.6	2.2	0.7	0.4	-0.8	1.3	2.6	-1.3
Medication: Omeprazole	0.6	0.7	1.9	-1.1	-1.0	-1.4	-0.1	1.0	0.7	0.0	-0.3	0.0	-0.2	-0.6	1.4
Heart disease (mother)	0.6	0.7	2.9	0.5	0.4	0.7	1.0	0.6	0.0	-1.3	0.6	1.7	-0.7	-0.5	-0.6
Leg fat mass (right)	0.6	2.3	14.2	0.0	-0.7	-1.2	0.5	0.1	1.3	3.8	1.1	-0.9	2.3	0.8	1.4
Number of full sisters	0.6	0.7	1.5	0.8	1.0	1.2	0.9	1.1	-0.1	0.2	1.0	-0.5	0.8	-0.2	-1.2
Suffer from ‘nerves’	0.6	1.0	2.0	0.1	0.5	0.1	1.4	1.2	-1.4	0.9	1.0	-1.1	1.3	-1.2	0.1
Mouth/teeth dental problems: Mouth ulcers	0.6	1.0	2.7	-1.4	-1.1	-1.1	-0.6	0.3	0.5	-1.5	-0.5	-0.4	-1.7	0.0	1.0
Financial situation satisfaction	0.6	0.8	3.6	0.4	-0.7	-1.0	-0.5	1.1	0.5	1.9	-0.4	0.3	0.3	0.6	1.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.5	-1.0	-0.8	-1.0	-1.1	1.0	1.0	0.8	-1.2	0.4	0.2	0.2	1.0
Pack years of smoking	0.6	0.9	5.9	-0.8	-0.2	-0.5	0.4	0.5	-0.0	0.7	1.7	-2.4	0.1	-0.1	0.5
Verbal and Numeric Reasoning (VNR)	0.5	1.1	4.0	0.9	-0.3	-0.5	-1.3	2.0	0.5	-1.0	-1.6	0.7	-1.5	-0.1	0.5
Breast Cancer	0.5	1.2	4.0	0.1	-0.4	-0.2	1.9	-0.2	-2.0	-0.6	1.4	-1.1	-1.1	-1.1	-0.0
Neuroticism (2016)	0.5	0.7	4.1	-0.9	0.2	0.0	-0.7	-1.1	-0.4	0.8	-0.8	-2.0	0.2	-0.4	0.1
Triglycerides	0.5	0.7	3.8	0.7	0.5	0.5	-0.4	-0.8	2.0	0.4	0.5	0.9	0.7	1.0	-0.7
Ulcerative Colitis	0.5	0.8	1.8	-0.4	-1.1	-1.3	0.9	0.5	-1.1	0.5	0.3	-0.6	0.1	-1.2	1.4
Allergy or Eczema	0.5	1.2	4.3	2.1	0.6	0.6	0.4	-2.0	1.1	-1.3	0.4	0.5	0.1	1.3	-0.6
Relative age of first facial hair	0.5	1.0	5.0	1.6	-0.2	-0.2	0.7	0.7	0.7	0.6	0.5	2.2	-0.4	1.6	0.1
Angina	0.5	0.6	2.2	1.3	-0.1	-0.4	-0.2	0.5	-0.2	1.5	-0.3	1.2	1.1	0.3	0.4
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.4	0.1	0.9	1.2	0.8	-0.4	-0.5	-0.7	0.0	1.2	0.1	-0.2	-1.2
Stomach or abdominal pain in last month	0.5	0.7	3.4	-1.3	-0.6	-0.2	-0.1	0.1	-0.2	0.5	-0.1	-1.8	-0.9	-1.1	-0.0
Chronic bronchitis/emphysema (father)	0.5	0.6	2.6	-0.6	0.1	0.3	-0.4	0.3	-1.2	-0.5	-1.4	0.1	-0.7	-1.6	-0.3
Trunk fat mass	0.5	2.1	10.8	-0.4	-1.3	-1.6	0.9	0.5	0.4	3.3	1.2	-1.3	1.5	-0.3	1.8
Had menopause	0.5	0.6	2.0	-0.4	-0.4	-0.5	0.3	-1.0	0.8	1.4	0.8	-1.0	0.7	0.4	0.8
Trunk fat-free mass	0.5	2.9	6.5	0.4	2.5	2.2	-0.8	-1.2	2.5	1.1	-0.5	0.7	1.8	2.2	-2.2
Noisy workplace	0.5	0.6	2.1	-1.0	0.3	0.3	1.4	-0.7	-0.9	-0.2	1.4	-0.1	0.3	-1.0	-0.3
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	2.4	0.8	0.2	0.6	0.5	0.2	1.4	0.1	0.4	1.5	0.6	0.9	-0.7
Illnesses of mother	0.5	0.6	1.4	-1.0	0.3	0.1	-1.2	-0.4	0.3	1.1	-0.7	-1.0	1.2	0.4	-0.0
Arm fat mass (right)	0.5	2.1	10.7	-0.2	-0.8	-1.2	0.9	0.5	1.1	3.3	1.6	-1.5	1.6	0.4	1.5
Trunk predicted mass	0.5	2.8	6.2	0.3	2.5	2.1	-0.9	-1.2	2.5	1.1	-0.6	0.7	1.7	2.2	-2.1
Exposure to tobacco smoke at home	0.5	0.5	4.3	0.3	0.4	0.4	0.7	-0.0	-2.1	-0.0	-0.3	0.2	0.2	-0.9	-0.3
Medication: Ventolin 100micrograms inhaler	0.5	0.6	2.3	0.2	-0.6	-0.8	0.6	-1.5	0.4	-1.0	0.5	0.3	-0.9	-0.9	0.8
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.7	-0.2	-0.7	-0.6	-1.0	-0.3	-0.9	1.3	-0.9	-0.9	0.5	-0.2	0.9
Arm fat-free mass (right)	0.5	2.8	6.5	0.4	2.3	2.0	-0.3	-1.4	2.0	2.1	0.2	0.5	2.5	1.9	-1.8
Exposure to tobacco smoke outside home	0.5	0.7	2.3	-1.4	-0.6	-0.2	0.7	-0.1	-1.0	-0.6	0.8	-0.5	-0.8	-1.5	0.3
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.5	1.7	-0.9	0.8	0.3	0.2	-0.8	-1.3	0.6	-0.1	-0.6	0.8	-1.0	-0.2
Health satisfaction	0.5	0.7	2.5	0.4	0.2	-0.2	1.2	0.1	-0.4	1.4	1.6	-1.1	1.0	-0.1	0.2
Eye problems/disorders: None of the above	0.5	0.6	1.2	0.5	-1.0	-0.5	0.5	1.1	-1.1	-0.3	0.4	-0.7	-0.8	-1.1	0.6
Mouth/teeth dental problems: Loose teeth	0.5	0.6	4.2	0.6	-0.4	0.1	0.5	2.1	-0.3	1.2	0.4	-0.7	0.6	-0.4	0.0
Angina (self-reported)	0.5	0.6	2.0	1.1	0.1	-0.3	-0.4	0.3	-0.4	1.4	-0.6	1.4	1.1	0.2	0.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.4	-0.5	0.2	0.1	1.0	1.0	-1.1	0.9	0.4	-1.0	0.2	-1.2	-0.1
Whole body fat mass	0.5	2.1	11.3	-0.4	-1.2	-1.6	0.9	0.4	0.7	3.4	1.3	-1.3	1.6	-0.1	1.8
Arm predicted mass (right)	0.5	2.7	6.6	0.5	2.4	2.0	-0.1	-1.4	1.7	2.0	0.3	0.3	2.6	1.7	-1.8
Overall health rating	0.5	1.1	2.8	-0.1	-1.1	-1.4	0.6	1.0	-0.3	1.7	1.5	-1.2	0.2	-0.6	1.4
Age at last live birth	0.5	0.8	2.1	1.4	-0.2	-0.1	1.4	-0.1	-0.8	-1.0	1.0	-0.7	-1.1	-0.9	-0.1
Commuting to job workplace: Walk	0.5	0.5	1.5	0.2	-0.5	-0.5	-0.4	1.2	-0.4	1.2	-0.4	-1.1	0.6	0.3	0.6
Medication for cholesterol	0.5	0.8	4.5	0.0	-0.9	-0.5	-0.4	2.1	0.2	-0.9	-0.9	-0.7	-1.0	-0.4	0.4
Arm fat mass (left)	0.5	2.0	10.6	-0.4	-0.8	-1.2	0.7	0.6	1.1	3.3	1.3	-1.4	1.7	0.3	1.6
Hearing aid user	0.5	0.6	2.8	0.1	-0.2	-0.3	-1.7	0.5	0.4	0.9	-1.3	0.2	0.7	0.7	0.2
Ever smoked	0.5	0.8	2.7	-1.2	1.1	0.7	-0.5	0.5	-1.6	0.6	-0.7	-0.8	0.8	-0.7	-0.6
Arm fat-free mass (left)	0.5	2.5	5.5	0.4	2.3	2.0	-0.2	-1.2	1.9	1.9	0.1	0.1	2.4	1.7	-1.8
Impedance of whole body	0.5	2.7	8.7	-0.8	-1.9	-1.7	0.3	0.8	-3.0	-1.5	-1.2	1.0	-1.9	-2.3	1.4
Depression (Nagel 2018)	0.4	0.6	3.1	0.0	-0.1	-0.4	-0.0	0.6	0.2	1.8	1.2	-0.8	1.1	0.0	0.6
Coronary Artery Disease (CAD)	0.4	0.4	1.1	-0.9	-0.1	-0.0	-0.8	-1.1	-0.7	-0.3	-0.3	-0.6	-1.1	-0.5	-0.3
Type 2 Diabetes (T2D) (2018)	0.4	0.8	4.2	-0.6	-0.9	-0.8	-0.4	0.1	-0.9	2.0	-0.5	-1.1	0.4	-0.8	0.7
Number of treatments/medications taken	0.4	0.8	3.7	-0.1	-0.1	-0.6	0.2	-1.0	-0.3	1.9	0.6	-1.2	1.2	-0.5	0.8
Pack years adult smoking proportion	0.4	0.7	3.8	-0.1	0.0	-0.1	0.7	0.5	-0.2	0.6	1.7	-1.9	0.2	-0.1	0.1
Townsend deprivation index at recruitment	0.4	0.6	1.8	1.2	-0.3	-0.6	0.1	0.9	-0.3	1.2	-0.0	1.4	0.7	-0.3	0.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	1.3	1.1	-0.0	0.0	1.0	0.8	-1.1	0.7	1.0	0.6	0.1	-0.6	0.0
Hair/balding pattern: Pattern 2	0.4	0.5	1.9	-1.4	-0.9	-0.8	-0.8	0.8	-0.6	-0.3	-0.1	0.1	-0.6	-0.1	0.7
Mouth/teeth dental problems	0.4	0.6	1.4	0.8	-0.5	0.4	-1.1	-1.2	0.7	-0.1	-0.8	0.1	-0.8	1.0	-0.7
Heart attack	0.4	0.5	2.2	0.5	0.5	-0.0	0.9	-0.0	-0.0	1.1	1.5	0.3	1.2	0.4	0.2
Time employed in main current job	0.4	0.5	2.4	0.7	0.1	0.2	0.7	-0.5	-0.6	-1.6	0.3	0.4	-1.2	-0.6	-0.3
Falls in the last year	0.4	0.5	1.7	0.3	-0.9	-0.9	0.1	-1.1	1.3	0.3	0.6	0.8	-0.0	-0.2	0.9
Number of live births	0.4	0.6	2.0	-1.0	-1.1	-0.6	0.3	1.4	-0.1	0.4	0.6	-1.1	-0.2	-0.5	0.6
Medication: Cholesterol lowering	0.4	0.5	1.7	0.4	0.9	0.7	-0.6	-0.5	-0.6	1.1	-0.9	-0.3	1.3	0.0	-0.7
Standing height	0.4	3.5	9.8	0.3	2.9	2.9	-0.3	-1.8	-0.1	-0.7	-1.9	2.8	0.7	0.1	-3.1
Mouth/teeth dental problems: Bleeding gums	0.4	0.5	2.3	0.5	0.9	0.6	0.3	0.5	-1.5	0.3	-0.4	-0.1	1.3	-0.5	-0.5
Gout (self-reported)	0.4	0.6	3.5	0.6	-0.5	-0.4	-0.8	0.9	-0.4	1.9	-0.5	-0.5	0.6	0.7	0.3
Number of full brothers	0.4	0.4	2.5	-0.3	-0.0	0.1	0.7	0.0	1.6	0.5	1.1	0.3	0.2	0.8	-0.1
Emphysema/chronic bronchitis	0.4	0.4	1.4	-0.3	1.0	0.8	0.4	-0.7	-0.3	-0.5	0.5	-1.2	0.3	-0.7	-0.5
Medication: Seretide 50 evohaler	0.4	0.4	1.9	-0.8	-0.7	-0.5	-0.5	-0.8	-0.1	-0.6	0.2	-1.4	-0.7	-0.2	0.5
Whole body fat-free mass	0.4	2.2	5.1	0.3	2.3	2.0	-0.4	-1.1	2.1	1.4	-0.1	0.2	1.9	1.6	-1.9
Eye problems/disorders: Cataract	0.4	0.5	2.1	-0.6	-0.1	-0.2	-0.7	-0.7	1.5	-0.1	-0.6	0.7	-0.6	1.0	0.1
Whole body water mass	0.4	2.2	5.0	0.4	2.2	1.9	-0.4	-1.0	2.0	1.5	-0.1	0.2	2.0	1.5	-1.8
High cholesterol (Self-reported)	0.4	0.8	2.4	-1.0	0.1	0.0	-0.2	-1.3	-1.6	-0.2	-0.4	-1.1	0.1	-1.6	0.1
Medication: Paracetamol	0.4	0.7	2.2	-1.5	-0.7	-1.2	-0.5	0.1	0.3	1.1	-0.2	-0.0	0.6	-0.4	1.4
Number of operations (self-reported)	0.4	0.6	2.0	-0.5	-0.2	-0.5	-1.0	-0.4	1.1	1.4	-0.0	-0.9	0.5	0.9	0.7
Heart attack/myocardial infarction (self-reported)	0.4	0.5	2.0	0.4	0.5	0.0	0.9	-0.1	-0.1	1.0	1.4	0.2	1.1	0.5	0.1
Heart disease (siblings)	0.4	0.4	1.3	0.1	0.2	0.3	0.8	-1.1	1.1	0.3	1.1	-0.6	-0.1	0.2	-0.2
Arm predicted mass (left)	0.4	2.1	4.9	0.3	1.9	1.6	-0.3	-1.0	2.1	2.1	0.3	-0.2	2.2	1.8	-1.3
Intelligence (Savage-Jansen 2018)	0.3	0.8	2.9	1.7	0.3	0.4	-0.7	1.0	0.1	-1.0	-1.4	0.7	-1.4	-0.4	-0.3
Prostate Cancer	0.3	0.5	1.5	0.6	-0.1	0.3	-0.8	-0.0	0.8	0.5	-1.2	0.7	-0.2	1.1	-0.5
Crohns Disease (2012)	0.3	0.5	3.0	0.5	0.4	0.7	0.1	-0.3	-1.7	-0.3	-0.4	-0.9	-0.1	-0.5	-0.8
Schizophrenia (2014)	0.3	0.8	2.8	-0.2	0.4	0.7	-1.0	-1.4	1.7	0.2	-0.5	-0.6	0.2	1.3	-0.5
Blood Red Count	0.3	3.0	6.4	-2.0	-1.5	-2.4	2.0	1.1	-0.2	2.1	2.0	-0.6	0.8	-1.5	2.5
Heel T-Score	0.3	2.2	6.2	-0.2	-0.5	-0.6	-0.3	0.9	-2.5	-1.7	-1.7	0.8	-2.5	-2.5	-0.4
Height	0.3	6.0	18.2	-1.7	4.3	3.8	-1.0	-2.9	-1.7	-0.6	-2.4	0.8	1.7	-0.0	-3.9
Chronotype (morning person)	0.3	0.6	1.3	0.2	-1.1	-1.1	-0.2	1.2	1.0	0.6	0.1	-0.8	0.2	0.8	1.0
Hair Pigment	0.3	9.8	23.1	4.8	4.0	3.9	0.9	-2.2	0.6	1.4	-0.5	4.8	3.7	2.5	-3.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	1.4	-1.2	-0.3	-0.4	-0.7	0.2	-0.5	0.5	-0.3	-0.7	0.1	-0.0	0.5
Impedance of leg (right)	0.3	1.4	3.5	-0.2	-1.4	-1.4	-0.8	0.4	-1.5	-0.8	-1.9	1.8	-1.0	-0.5	1.2
Hayfever, allergic rhinitis or eczema	0.3	0.6	2.5	1.6	0.3	0.2	0.7	-1.1	0.1	-1.4	0.2	0.5	-0.1	0.3	-0.3
Sitting height	0.3	2.0	5.7	0.7	2.0	1.8	-0.3	-1.7	0.4	0.2	-1.7	2.4	1.0	0.5	-1.8
Had other major operations	0.3	0.4	1.7	-0.3	0.3	0.2	0.6	-1.1	1.3	0.1	0.6	-0.6	-0.2	0.5	0.1
Fluid intelligence score	0.3	0.7	4.1	2.0	0.6	0.4	0.2	0.8	0.7	-1.0	-0.3	1.2	-0.6	-0.0	-0.4
Weight	0.3	1.5	7.6	0.2	0.6	0.3	0.2	-0.5	1.8	2.8	0.6	-0.4	2.1	1.2	-0.0
Father’s age at death	0.3	0.4	1.6	0.9	-0.1	-0.1	1.2	0.5	0.5	-0.8	0.9	0.0	-0.8	-0.2	-0.0
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.4	1.3	1.1	0.7	0.7	0.3	-0.9	-0.5	0.8	0.5	0.1	0.8	-0.2	-0.7
Qualifications: A levels/AS levels or equivalent	0.3	0.8	2.7	1.6	-0.4	0.0	-0.3	0.4	0.9	-1.4	-0.6	0.4	-1.6	0.3	-0.3
Tense / ‘highly strung’	0.3	0.5	2.2	-0.7	0.3	0.1	0.9	-0.6	-0.5	-0.3	1.0	-1.5	0.3	-0.7	-0.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.4	-1.0	-0.5	-0.5	0.2	0.6	0.5	-0.7	0.9	-0.5	-1.2	0.4	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.3	0.4	1.9	0.0	0.4	0.3	-1.4	-0.1	1.0	-0.1	-0.7	-0.0	-0.8	0.8	-0.4
Chest pain or discomfort	0.3	0.4	1.6	0.6	0.7	0.6	-1.3	0.4	0.3	0.1	-0.8	0.8	0.5	0.5	-0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	0.9	-0.9	-0.8	-0.9	0.2	-0.5	-0.5	-0.5	0.1	-0.1	-0.7	-0.5	0.7
Leg fat-free mass (right)	0.3	1.5	3.6	0.3	1.9	1.7	0.6	-1.0	1.4	1.3	0.7	-0.3	1.6	0.6	-1.6
Illnesses of father: None of the above (group 1)	0.3	0.4	2.9	0.1	0.0	0.1	-0.5	-0.6	-0.2	-0.3	-0.4	1.7	0.6	0.7	-0.2
Leg predicted mass (right)	0.3	1.6	3.7	0.3	1.9	1.8	0.5	-1.0	1.5	1.3	0.7	-0.3	1.7	0.7	-1.7
Number of self-reported non-cancer illnesses	0.3	0.6	3.1	0.4	-0.2	-0.4	0.7	-0.0	-0.9	1.8	0.1	0.1	1.0	-0.9	0.3
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.3	0.9	-0.4	-0.1	-0.2	-1.1	0.9	0.8	0.5	-0.3	0.0	0.7	0.1
Supplements: Fish oil (including cod liver oil)	0.3	0.3	1.8	-0.8	0.3	0.3	-0.8	-1.3	0.5	-0.3	-0.3	-0.0	0.3	0.6	-0.2
Illnesses of father: High blood pressure	0.3	0.4	1.7	0.3	0.4	0.2	0.2	-1.1	-0.1	1.0	0.1	-0.3	1.3	0.0	-0.1
Basal metabolic rate	0.3	1.8	4.2	0.3	1.8	1.5	-0.2	-1.0	2.0	1.7	0.1	0.1	1.9	1.4	-1.4
Irritability	0.3	0.5	1.7	-0.1	0.3	-0.1	-0.0	1.0	-0.8	0.8	-0.7	-0.8	0.7	-1.3	0.1
Age started oral contraceptive pill	0.3	0.4	2.2	0.6	0.0	0.3	0.2	0.2	-0.7	0.7	0.6	-1.5	0.2	-0.3	-0.2
Myopia	0.3	0.4	1.2	1.1	-0.3	0.1	-0.2	-1.0	0.8	-0.3	0.0	1.0	-0.9	0.3	0.0
Basal cell carcinoma (self-reported)	0.3	0.3	1.0	-0.1	-0.5	-0.5	-0.3	0.5	0.2	1.0	-0.0	1.0	0.6	1.0	0.2
Alzheimer’s Disease (in father)	0.2	0.3	1.0	0.2	0.4	0.2	0.3	0.0	0.2	0.2	1.0	-1.0	0.8	0.2	-0.3
Ulcerative Colitis (UC)	0.2	0.4	1.7	0.6	0.5	0.4	-0.1	-0.6	-0.4	1.3	-0.4	0.3	1.3	0.1	-0.2
Age at First Birth	0.2	0.2	1.4	0.2	-0.0	0.3	-0.2	0.5	-0.3	-0.3	-0.4	-1.2	-0.6	-0.3	-0.5
HDL Cholesterol	0.2	0.3	0.9	-1.0	0.9	0.6	-0.4	-0.0	0.2	0.4	-0.3	0.6	0.3	0.5	-0.6
Respiratory disease	0.2	0.3	2.0	0.6	-0.1	0.1	0.2	-1.4	0.2	-0.1	0.2	-1.3	0.1	-0.1	-0.1
Vitamin and mineral supplements	0.2	0.3	0.8	-0.9	-0.1	0.4	0.2	0.7	0.8	-0.7	0.6	0.2	-0.5	0.6	-0.5
Diabetes (mother)	0.2	0.3	0.6	0.7	-0.1	-0.2	0.4	0.6	0.7	0.5	0.7	0.8	0.2	0.4	0.3
Leg fat-free mass (left)	0.2	1.1	2.3	0.1	1.5	1.3	0.2	-0.7	1.4	1.3	0.3	-0.1	1.5	0.7	-1.2
Impedance of leg (left)	0.2	0.8	2.8	0.3	-0.7	-0.8	-0.2	-0.2	-1.7	-0.2	-1.2	1.6	-0.2	-0.5	0.7
Leg predicted mass (left)	0.2	0.9	2.0	0.0	1.4	1.2	0.2	-0.6	1.4	1.3	0.3	-0.1	1.4	0.6	-1.1
Allergy	0.2	0.5	3.3	-1.8	-0.1	-0.2	-1.1	0.5	-0.0	1.0	-0.3	0.5	0.1	0.2	0.3
Asthma	0.2	0.4	1.5	1.2	-0.8	-0.5	0.2	0.4	-0.3	0.5	-0.5	-0.7	0.3	-0.7	0.6
Neck or shoulder pain in last month	0.2	0.2	1.2	-0.4	-0.1	-0.2	-0.0	0.0	1.1	0.2	0.8	-0.4	-0.2	0.8	0.1
Comparative height size at age 10	0.2	1.2	4.5	-2.1	1.1	1.0	-1.1	-0.7	-0.0	1.0	-1.4	0.4	1.2	-0.3	-1.0
Had major operations	0.2	0.2	0.7	0.2	-0.0	-0.0	-0.3	0.6	-0.7	0.9	-0.4	-0.9	0.3	-0.5	-0.0
Qualifications: nursing, teaching	0.2	0.4	1.5	-0.1	-0.1	-0.3	-0.6	0.1	-0.6	-1.2	-1.0	-0.2	-0.8	-0.5	0.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.3	0.6	-0.4	-0.5	-0.5	0.4	-0.8	0.3	0.3	0.8	-0.8	0.5	-0.1	0.5
Back pain experienced in last month	0.2	0.3	0.9	-0.2	-0.4	-0.5	0.9	-0.1	0.2	-0.6	0.9	-0.4	-0.8	-0.1	0.3
Asthma (self-reported)	0.2	0.3	1.0	0.8	-0.7	-0.4	-0.1	0.1	-0.2	0.7	-0.5	-1.0	0.5	-0.4	0.5
Risk taking	0.2	0.3	1.0	0.9	-0.2	0.1	-0.7	0.3	0.2	-0.9	-1.0	0.4	-0.6	-0.5	0.1
Ever depressed for a whole week	0.2	0.3	1.0	-0.7	-0.3	-0.2	0.2	0.7	0.1	0.4	0.8	-1.0	0.3	0.4	0.3
Unable to work because of sickness or disability	0.2	0.2	0.8	-0.5	0.2	-0.4	0.3	0.9	0.6	0.4	0.4	-0.4	0.7	-0.1	0.3
Cholesterol lowering medication	0.2	0.3	0.8	-0.2	-0.1	-0.2	0.9	-0.9	0.4	0.0	0.9	0.6	-0.5	-0.2	0.3
Ovarian Cancer	0.1	0.1	0.4	0.0	-0.2	-0.3	0.2	0.4	-0.4	0.6	-0.1	0.2	0.4	0.5	0.3
Supplements: Zinc	0.1	0.1	0.2	0.4	-0.4	-0.5	0.3	-0.1	0.3	0.3	0.3	-0.2	-0.1	-0.2	0.4
Age when periods started (menarche)	0.1	0.3	1.9	-0.1	-0.5	-0.4	0.4	0.1	0.3	0.6	1.4	-0.7	0.5	0.0	0.4
Multivitamins +/- minerals	0.1	0.1	0.8	0.9	-0.1	-0.2	-0.3	-0.4	0.1	0.5	-0.4	0.0	-0.1	0.2	0.3
Osteoporosis (self-reported)	0.1	0.2	0.6	0.8	-0.0	0.3	-0.1	-0.5	0.5	-0.5	0.4	0.2	0.2	0.4	-0.4
Tanning	0.0	0.5	2.0	0.9	1.4	1.0	0.8	0.1	-0.1	-0.2	0.3	0.7	0.4	0.4	-0.9

Hub : Genes

BCAR3

Models

Trait associations