TWAS hub - TNFRSF10A

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.2720	0.0560	1.1e-05	0.091	NA	0.081	NA	0.083	7.1e-08	NA	3.7e-07	NA	2.8e-07
2	GTEx	Artery Aorta	0.5970	0.0640	5.2e-10	0.269	NA	0.344	NA	0.409	4.3e-15	NA	1.1e-19	NA	3.8e-24
3	GTEx	Cells Transformed fibroblasts	0.4130	0.0590	8.5e-10	0.220	NA	0.298	NA	0.328	2.0e-16	NA	1.0e-22	NA	3.4e-25
4	METSIM	Adipose	0.0632	0.0276	1.5e-02	0.042	0.009	0.038	0.045	0.041	6.0e-07	0.0130	1.8e-06	2.5e-07	8.4e-07
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0431	0.0203	3.1e-03	0.022	0.018	0.012	NA	0.010	1.5e-03	0.0038	1.4e-02	NA	2.4e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Eye problems/disorders: Cataract	6.4	7.4	9.0	2.5	3.0	2.7	3.0	2.3
Ever had hysterectomy (womb removed)	5.3	5.9	7.8	2.6	2.8	2.8	2.5	1.1
Medication: Ibuprofen	5.1	6.1	8.3	-2.3	-1.6	-2.6	-2.7	-2.9
Ever had bowel cancer screening	5.0	5.9	7.9	2.8	1.6	2.4	2.5	2.6
Alcohol drinker status: Never	4.6	5.5	7.6	-1.7	-2.7	-2.0	-2.4	-2.8
Medication: Ibuprofen (e.g. Nurofen)	4.3	5.5	7.7	-2.1	-1.5	-2.5	-2.6	-2.8
Trunk fat mass	3.9	16.6	20.0	3.9	4.5	4.4	3.2	4.2
Serious illness, injury or assault of a close relative in last 2 years	3.8	4.4	7.1	-0.8	-2.4	-2.5	-1.6	-2.7
Eye problems/disorders: None of the above	3.8	4.4	5.6	-1.4	-2.3	-2.4	-2.3	-1.9
Trunk fat percentage	3.4	13.8	16.6	3.5	4.0	4.1	3.0	3.8
Blood White Count	3.3	24.3	31.5	5.4	4.9	5.6	4.6	3.9
Supplements: Glucosamine	3.3	4.3	7.1	-2.4	-2.0	-1.9	-2.7	-0.9
Leg fat mass (right)	3.2	12.5	16.3	3.3	4.0	3.7	2.6	3.8
Average weekly champagne plus white wine intake	3.2	4.3	5.5	-1.8	-2.0	-2.3	-1.8	-2.3
Pain type(s) experienced in last month: Hip pain	3.2	4.0	5.6	-2.0	-2.4	-1.8	-2.0	-1.9
Leg fat mass (left)	3.2	12.4	15.7	3.3	4.0	3.7	2.6	3.9
Average weekly spirits intake	3.1	3.9	5.1	2.2	1.7	2.3	2.3	1.2
Diabetes (father)	3.1	3.9	5.4	2.3	2.0	1.9	1.9	1.6
Body fat percentage	3.1	12.1	14.5	3.2	3.8	3.8	2.7	3.7
Leg fat percentage (right)	3.0	11.0	14.8	2.8	3.9	3.5	2.5	3.7
Mouth/teeth dental problems: Loose teeth	3.0	3.6	6.1	1.5	1.7	2.5	1.2	2.3
Whole body fat mass	3.0	12.5	15.2	3.4	3.9	3.8	2.6	3.9
Leg fat percentage (left)	3.0	10.8	14.0	3.0	3.7	3.3	2.5	3.7
Supplements: Vitamin C	2.9	3.4	5.7	-2.1	-1.2	-2.0	-2.4	-1.2
Arm fat mass (left)	2.8	11.3	15.0	3.0	3.9	3.6	2.5	3.7
Mouth/teeth dental problems: Dentures	2.7	4.6	6.2	2.2	2.3	2.4	2.5	0.8
Medication for cholesterol	2.6	3.9	5.7	-1.9	-1.5	-1.7	-2.4	-2.2
Prostate Cancer	2.5	3.6	5.9	-0.8	-1.5	-2.2	-2.4	-2.1
Weight	2.5	12.5	16.2	3.6	4.0	3.6	2.3	3.8
Vitamin and mineral supplements	2.4	3.2	4.7	2.2	1.6	2.1	1.7	1.3
Medication: Cholesterol lowering	2.4	3.7	4.7	-2.1	-2.1	-1.4	-2.2	-1.7
Illnesses of father: None of the above (group 1)	2.4	3.0	4.7	-1.5	-2.2	-1.7	-1.9	-1.2
Arm fat mass (right)	2.3	9.3	12.2	2.8	3.5	3.3	2.3	3.2
Medication: Ventolin 100micrograms inhaler	2.3	3.0	5.3	1.4	2.3	1.8	1.7	1.3
Angina (self-reported)	2.3	3.0	6.1	1.2	1.6	2.0	1.0	2.5
Medication: Seretide 50 evohaler	2.3	2.6	6.3	-2.2	-1.0	-1.0	-2.5	-0.1
Average weekly fortified wine intake	2.2	2.5	3.8	1.9	1.6	1.7	1.6	0.9
Medication: Atenolol	2.2	2.7	3.6	1.9	1.8	1.6	1.9	0.8
Arm fat percentage (left)	2.1	8.3	11.2	2.3	3.3	3.1	2.3	3.2
Angina	2.0	2.6	6.1	1.0	1.5	1.7	0.9	2.5
Hip circumference	2.0	8.8	11.7	2.8	3.4	3.1	2.2	3.2
Chronic bronchitis/emphysema (mother)	2.0	2.3	5.1	1.1	1.1	1.4	2.2	1.5
Mean Putamen Volume	1.9	2.2	4.9	2.2	1.6	1.2	1.2	0.7
Arm fat-free mass (right)	1.9	9.9	12.8	3.4	3.4	3.1	1.9	3.6
Heart disease (siblings)	1.9	2.3	4.8	-2.2	-1.4	-1.4	-1.7	0.1
Arm predicted mass (left)	1.9	9.6	12.6	3.5	3.4	3.0	1.8	3.3
Hair/balding pattern: Pattern 4	1.8	4.4	6.6	1.5	2.4	2.6	2.1	1.7
Arm predicted mass (right)	1.8	9.0	11.7	3.4	3.2	2.9	1.7	3.4
Friendships satisfaction	1.8	2.2	4.4	-1.1	-1.3	-1.7	-1.0	-2.1
Age when periods started (menarche)	1.7	4.1	5.8	2.4	2.2	2.0	1.5	1.9
Pulse wave Arterial Stiffness index	1.7	1.9	6.6	0.9	1.3	0.8	-0.2	2.6
Exposure to tobacco smoke at home	1.7	1.9	2.7	1.4	1.6	1.4	1.5	0.7
Wheeze or whistling in the chest in last year	1.7	3.1	5.0	1.3	2.2	1.7	1.6	1.9
Handedness (chirality/laterality): Left-handed	1.7	2.0	3.6	-1.2	-1.4	-1.5	-0.7	-1.9
Arm fat-free mass (left)	1.7	8.7	11.6	3.4	3.3	2.9	1.6	3.2
Commuting to job workplace: Cycle	1.7	2.1	2.9	1.5	1.7	1.7	0.8	1.3
Leg fat-free mass (left)	1.6	8.4	10.9	3.0	3.2	2.9	1.8	3.3
Leg predicted mass (left)	1.6	8.3	11.2	3.0	3.2	2.9	1.8	3.3
Waist circumference	1.6	6.0	9.5	2.0	2.8	2.5	1.7	3.1
Arm fat percentage (right)	1.6	6.3	8.5	2.1	2.9	2.8	1.9	2.7
Basal metabolic rate	1.6	8.9	11.2	3.3	3.3	3.0	1.7	3.4
Ever depressed for a whole week	1.6	1.9	3.1	1.8	1.1	1.5	0.5	1.7
Ulcerative Colitis (UC)	1.5	2.8	4.3	1.5	2.1	1.6	1.4	1.6
Multivitamins +/- minerals	1.5	1.9	2.9	-1.5	-1.3	-1.7	-1.1	-1.2
Glaucoma (self-reported)	1.4	1.6	2.5	1.0	1.6	1.3	1.5	0.9
Whole body fat-free mass	1.4	7.8	9.9	3.1	3.0	2.8	1.6	3.1
Leg fat-free mass (right)	1.4	7.4	10.3	2.9	2.9	2.7	1.7	3.2
Long-standing illness, disability or infirmity	1.4	2.2	4.8	-1.5	-0.9	-1.3	-2.2	-1.1
Smoking status: Current	1.4	2.3	3.2	1.8	1.6	1.6	1.6	0.8
Leg predicted mass (right)	1.4	7.3	9.9	2.9	2.9	2.6	1.7	3.2
BMI	1.3	7.3	10.0	2.6	3.2	2.7	2.0	2.9
Lung FVC	1.3	6.6	10.3	-1.6	-3.2	-2.4	-2.8	-2.5
Body mass index (BMI)	1.3	5.4	7.4	1.9	2.7	2.4	1.7	2.6
Had other major operations	1.3	1.6	3.2	1.0	1.8	1.2	1.1	1.2
Number of live births	1.3	1.9	3.9	-1.0	-1.6	-1.0	-2.0	-0.9
Migraine (self-reported)	1.3	1.6	2.5	-1.6	-1.3	-1.2	-0.7	-1.5
Heart disease (mother)	1.3	1.6	3.7	1.2	0.5	1.3	1.9	1.0
Family relationship satisfaction	1.3	1.6	3.1	-0.3	-1.5	-1.5	-0.8	-1.8
Whole body water mass	1.3	7.6	9.6	3.1	3.0	2.7	1.5	3.1
Financial situation satisfaction	1.3	1.6	2.3	-1.2	-1.3	-1.3	-1.1	-1.5
Number of operations (self-reported)	1.3	1.9	3.5	1.3	1.9	1.5	1.0	1.1
Unable to work because of sickness or disability	1.3	1.6	3.1	-1.8	-1.1	-1.1	-1.3	-1.0
Alzheimer’s Disease (in father)	1.2	1.3	1.9	1.2	1.4	1.0	1.0	1.2
Ovarian Cancer	1.2	1.6	3.2	-0.5	-1.8	-1.7	-0.3	-1.2
Current tobacco smoking	1.2	2.0	2.9	1.5	1.5	1.4	1.7	1.0
Heel bone mineral density (BMD) T-score, automated (left)	1.2	2.7	5.2	1.7	1.8	1.5	2.3	0.2
Heel bone mineral density (BMD) T-score, automated (right)	1.2	2.7	4.7	1.6	1.6	1.7	2.2	1.0
Age at first live birth	1.2	2.1	3.0	1.3	1.0	1.6	1.4	1.7
Mouth/teeth dental problems: Mouth ulcers	1.2	2.0	3.1	-0.8	-1.2	-1.5	-1.6	-1.8
Osteoarthritis (self-reported)	1.2	1.5	2.9	-1.4	-1.2	-1.7	-0.7	-0.9
Age started oral contraceptive pill	1.2	1.5	1.9	1.3	1.4	1.1	1.2	0.9
Medication: Omeprazole	1.1	1.3	2.2	-1.2	-0.4	-1.5	-1.5	-0.8
Comparative height size at age 10	1.1	5.8	8.8	2.9	2.5	3.0	1.1	2.1
Ever had stillbirth, spontaneous miscarriage or termination	1.1	1.2	1.4	-1.2	-1.1	-1.2	-1.2	-0.6
Back pain experienced in last month	1.1	1.6	3.7	-1.9	-0.6	-0.9	-1.6	-0.5
Osteoporosis (self-reported)	1.1	1.4	4.4	-0.8	-0.9	-0.7	-2.1	-0.6
Medication: Gliclazide	1.1	1.2	2.5	-1.6	-1.3	-0.6	-1.1	-0.1
Breast Cancer	1.0	2.4	3.5	1.0	1.1	1.8	1.9	1.8
Smoking Status	1.0	2.4	3.7	1.5	1.5	1.9	0.9	1.7
Taking other prescription medications	1.0	1.5	3.1	-1.8	-0.6	-1.2	-1.6	-0.1
Trunk fat-free mass	1.0	6.0	8.2	2.9	2.7	2.4	1.1	2.7
Pulse rate	1.0	1.6	2.4	1.6	1.1	1.1	1.3	1.3
Trunk predicted mass	1.0	5.9	8.3	2.9	2.7	2.4	1.2	2.7
Standing height	1.0	10.4	17.9	4.2	3.4	3.3	1.8	2.9
Medication for pain relief, constipation, heartburn	1.0	1.6	2.6	1.6	0.7	1.4	1.5	0.9
Mineral and other dietary supplements	1.0	1.3	3.0	1.7	0.6	0.8	1.6	0.2
Supplements: Fish oil (including cod liver oil)	1.0	1.4	2.5	-1.6	-1.0	-0.9	-1.5	-0.3
High cholesterol (Self-reported)	1.0	1.8	2.2	-1.4	-1.5	-1.0	-1.4	-1.3
Schizophrenia (2018)	0.9	1.9	3.1	-1.5	-1.4	-1.5	-1.8	-0.1
Alzheimer’s Disease (in mother)	0.9	1.0	2.1	-0.6	-1.3	-1.4	-0.5	-0.9
Alzheimer’s Disease (including proxy)	0.9	1.4	2.4	-0.7	-1.5	-1.5	-1.0	-0.8
Supplements: Zinc	0.9	1.0	2.4	-1.5	-0.4	-1.0	-1.2	0.2
Medication: Simvastatin	0.9	1.4	2.2	-1.2	-1.5	-1.0	-0.8	-1.2
Pulse wave peak to peak time	0.9	1.1	4.4	-0.3	-0.7	-0.3	0.6	-2.1
Alcohol intake frequency.	0.9	2.0	4.4	-1.4	-2.1	-1.4	-0.9	-0.9
Commuting to job workplace: Car/motor vehicle	0.9	1.1	1.7	-0.7	-1.1	-1.1	-1.3	-0.9
Wears glasses or contact lenses	0.9	1.1	2.3	0.8	1.0	1.5	0.7	0.9
Commuting to job workplace: Public transport	0.9	1.0	1.6	-1.1	-1.0	-1.3	-1.1	-0.4
Risk taking	0.9	1.3	2.5	-0.1	-1.3	-0.7	-1.3	-1.6
Body Mass Index (BMI) (2010)	0.8	1.1	1.6	1.0	1.3	0.8	1.0	1.0
Schizophrenia (2014)	0.8	1.7	3.8	-1.3	-1.3	-1.0	-1.9	-0.3
Neuroticism	0.8	1.8	3.2	1.6	1.8	1.2	1.3	0.5
Number of treatments/medications taken	0.8	1.5	2.3	-1.5	-0.9	-1.4	-1.4	-0.7
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	2.7	-1.1	-0.2	-0.3	-1.6	0.7
Worrier / anxious feelings	0.8	1.5	3.5	1.1	1.5	0.6	1.9	0.0
Lung cancer (father)	0.8	1.0	1.8	1.0	0.5	1.2	0.6	1.4
Length of working week for main job	0.8	0.9	2.2	1.0	1.5	1.0	0.4	0.6
Medication: Aspirin	0.8	1.0	1.7	-0.9	-1.3	-1.1	-1.0	-0.7
Alcohol drinker status: Previous	0.8	0.9	2.3	-0.8	-1.5	-1.1	-0.5	-0.5
Height	0.7	12.7	19.3	4.4	3.6	3.8	1.5	3.9
Medication for hormone replacement therapy	0.7	0.8	1.4	0.8	0.3	1.0	1.2	0.8
Hearing difficulty/problems with background noise	0.7	1.1	2.8	-1.7	-0.7	-0.6	-1.0	-0.9
Medication: Amlodipine	0.7	0.9	2.5	0.8	0.5	1.0	1.6	0.0
Chest pain or discomfort	0.7	1.0	2.0	0.3	1.4	1.2	0.2	1.2
Illnesses of father: Heart disease	0.7	0.9	2.1	-0.5	1.3	0.8	-0.4	1.4
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.4	2.4	-0.7	-1.2	-1.6	-1.3	-1.0
Depressed Affect (Nagel 2018)	0.6	1.2	2.0	0.8	1.1	1.4	0.2	1.4
Schizophrenia vs Biploar Disorder	0.6	0.8	1.7	-1.0	-0.9	-0.8	-1.3	0.0
Crohns Disease (2012)	0.6	0.9	1.6	-0.9	-0.8	-1.0	-0.9	-1.3
Fasting Glucose	0.6	0.7	1.5	-0.5	0.8	1.0	0.5	1.2
HDL Cholesterol	0.6	1.1	1.9	-1.4	-1.4	-0.4	-0.8	-0.9
Neuroticism (2016)	0.6	0.9	2.1	-0.2	-1.0	-0.9	-0.7	-1.4
Rheumatoid Arthritis	0.6	0.9	2.0	0.9	1.1	0.6	1.4	-0.1
Blood Red Count	0.6	6.1	19.2	-1.9	-1.5	-1.8	-4.4	-1.5
Hand grip strength (right)	0.6	1.6	2.5	1.4	1.6	0.5	1.4	1.0
Sitting height	0.6	4.4	9.1	3.0	2.0	1.9	0.7	2.2
Had menopause	0.6	0.8	1.3	1.1	1.0	0.3	1.1	0.7
Pain all over the body in last month	0.6	0.7	1.9	0.6	0.1	0.3	1.4	1.0
Medication: Ramipril	0.6	0.7	1.9	-1.1	-1.4	-0.3	-0.7	0.2
Time employed in main current job	0.6	0.7	1.2	-0.1	1.1	0.6	1.0	1.1
Alcohol intake versus 10 years previously	0.6	0.9	1.6	-0.8	-1.2	-0.5	-0.8	-1.3
Illnesses of mother	0.6	0.7	2.2	-0.1	-0.7	-0.7	-1.5	-0.5
Pulse wave reflection index	0.6	0.7	2.4	-0.0	-0.2	0.2	-1.6	1.0
Ever highly irritable/argumentative for 2 days	0.6	0.8	1.9	-0.9	-0.5	-1.4	-0.5	-0.8
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	1.7	1.3	1.0	0.6	0.9	0.9
Worry too long after embarrassment	0.6	0.9	2.2	0.4	1.5	0.9	0.5	1.1
Overall health rating	0.6	1.3	2.3	0.8	1.1	1.5	0.5	1.5
Medication: Aspirin	0.6	0.8	1.2	-0.9	-1.1	-1.0	-0.9	-0.4
Medication: Paracetamol	0.6	1.0	2.1	-1.4	-0.4	-1.2	-1.0	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	1.3	-0.8	-0.2	-1.1	-1.1	-0.8
Bipolar Disorder or Schizophrenia	0.5	1.1	2.2	-1.5	-0.9	-0.7	-1.4	-0.1
Blood Platelet Count	0.5	5.4	10.6	-1.1	-3.3	-1.9	-2.1	-2.6
Hearing difficulty/problems: Yes	0.5	0.8	1.6	-1.3	-0.7	-0.9	-0.3	-0.9
Bilateral oophorectomy (both ovaries removed)	0.5	0.6	2.0	1.4	0.6	0.5	0.7	0.3
Stomach or abdominal pain in last month	0.5	0.6	1.9	-0.5	0.5	0.1	-0.8	1.4
Medication: Levothyroxine sodium	0.5	0.9	2.1	-0.9	-0.6	-0.9	-0.6	-1.4
Chronic bronchitis/emphysema (father)	0.5	0.6	1.0	0.4	0.3	1.0	0.9	1.0
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.8	2.1	-1.0	-0.6	-0.7	-1.4	0.0
Illnesses of siblings	0.5	0.7	3.2	-0.1	0.1	-0.5	-0.2	-1.8
Happiness	0.5	0.6	0.8	-0.9	-0.8	-0.7	-0.9	-0.1
Peak expiratory flow (PEF)	0.5	1.1	2.1	-0.8	-1.1	-1.3	-1.5	-0.6
Neck or shoulder pain in last month	0.5	0.7	1.8	0.6	0.8	0.8	1.3	0.2
Commuting to job workplace: Walk	0.5	0.6	0.9	-0.9	-0.6	-0.7	-0.7	0.9
Number of self-reported non-cancer illnesses	0.5	0.9	2.9	0.0	1.1	0.5	0.6	1.7
Guilty feelings	0.5	0.8	1.9	0.9	1.4	1.0	-0.2	0.5
Medication: Blood pressure	0.5	0.9	1.8	1.1	0.6	0.6	1.3	0.9
Medication: Bendroflumethiazide	0.5	0.8	1.6	-0.5	-1.3	-1.3	0.1	-0.8
Illnesses of father: High blood pressure	0.5	0.6	2.0	0.0	0.5	-0.2	0.9	-1.4
Neuroticism (Nagel 2018)	0.4	0.8	1.5	0.9	1.2	1.0	0.1	1.0
Irritable Bowel Disease (IBD)	0.4	0.9	1.3	1.0	1.1	1.1	1.1	0.3
Triglycerides	0.4	0.6	1.3	-0.2	1.1	0.7	-0.2	1.0
Type 2 Diabetes (T2D) (2018)	0.4	0.7	1.3	0.4	1.1	1.1	0.1	0.9
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.3	-1.0	-0.4	-0.6	-1.1	0.3
Townsend deprivation index at recruitment	0.4	0.5	1.7	-0.3	0.0	-0.7	-0.6	-1.3
Maternal smoking around birth	0.4	0.5	1.6	0.5	0.4	0.6	1.3	0.5
Number of incorrect matches in round	0.4	0.7	1.1	0.8	1.0	0.9	1.1	0.1
Hair/balding pattern: Pattern 2	0.4	0.5	1.1	-0.4	-0.3	-1.1	-1.0	0.3
Qualifications: None of the above	0.4	0.8	1.2	0.6	0.7	0.9	1.0	1.1
Mouth/teeth dental problems	0.4	0.7	1.1	-0.9	-0.8	-1.0	-0.8	0.2
Fluid intelligence score	0.4	0.7	1.5	0.7	-0.2	-0.7	-1.2	-1.1
Depression (self-reported)	0.4	0.5	0.9	0.9	0.3	0.8	0.5	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.4	3.5	-0.7	-1.1	-1.2	-1.9	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	1.1	-0.2	-0.8	-0.6	-0.7	-1.0
Number of children fathered	0.4	0.5	1.6	0.2	0.4	0.4	0.6	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.4	0.7	-0.8	-0.0	-0.8	-0.6	-0.7
Knee pain experienced in last month	0.4	0.6	1.9	0.4	1.4	0.7	0.3	0.6
Smoking status: Previous	0.4	0.6	1.1	-1.0	-0.8	0.0	-1.1	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	2.4	0.8	1.6	0.2	-0.0	1.0
Supplements: Calcium	0.4	0.4	1.1	0.6	1.0	0.3	0.3	0.8
Reaction Time	0.3	0.6	1.3	-0.8	-0.6	-1.1	-0.2	-0.7
Verbal and Numeric Reasoning (VNR)	0.3	0.7	1.7	0.0	-0.8	-0.6	-0.9	-1.3
LDL Cholesterol	0.3	0.4	0.8	-0.5	0.1	-0.7	-0.8	-0.9
Lung FEV1/FVC ratio	0.3	1.4	2.2	-1.3	-1.3	-1.0	-1.5	-0.6
Hand grip strength (left)	0.3	0.7	1.3	0.7	1.1	0.2	0.9	1.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	1.0	-0.6	-0.6	-0.6	-1.0	-0.3
High blood pressure	0.3	0.9	2.4	0.7	0.3	0.8	1.6	1.0
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.2	1.1	-0.2	-0.4	0.7	0.1
Alcohol usually taken with meals	0.3	0.4	0.7	0.7	0.6	0.8	0.6	0.5
Nervous feelings	0.3	0.5	0.9	0.8	0.9	0.4	0.9	-0.2
Financial difficulties in last 2 years	0.3	0.4	0.8	0.6	0.7	-0.1	0.9	-0.2
Father’s age at death	0.3	0.3	0.8	0.9	-0.6	-0.1	-0.5	-0.6
Falls in the last year	0.3	0.3	1.5	0.2	0.0	-0.4	-0.2	-1.2
Forced expiratory volume in 1-second (FEV1)	0.3	0.9	2.8	-0.4	-0.7	-0.8	-1.7	-0.5
Asthma	0.3	0.6	1.8	-1.3	0.4	-0.3	-0.8	0.7
Prospective memory result	0.3	0.4	0.7	-0.9	-0.5	-0.1	-0.7	-0.8
Birth weight of first child	0.3	0.5	1.3	-1.2	-0.3	-0.6	-0.7	0.1
Had major operations	0.3	0.4	1.0	0.2	1.0	0.5	-0.4	0.8
Leg pain on walking	0.3	0.3	0.7	0.8	0.3	0.8	0.3	0.4
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	0.6	-0.8	-0.6	-0.2	-0.1	-0.7
Qualifications: nursing, teaching	0.3	0.5	1.5	0.8	-0.5	-0.6	0.1	-1.2
Breast cancer (self-reported)	0.3	0.3	0.7	-0.3	-0.5	-0.0	-0.7	-0.8
Eye problems/disorders: Glaucoma	0.3	0.3	1.1	-0.0	0.7	0.4	1.0	0.2
Medication: Lisinopril	0.3	0.4	0.5	0.7	0.7	0.4	0.7	0.5
Ever smoked	0.3	0.6	1.1	-0.7	-0.5	0.5	-1.0	1.0
Average weekly beer plus cider intake	0.3	0.5	1.3	0.1	0.8	0.5	1.2	0.3
Irritability	0.3	0.6	1.9	-0.6	-0.5	-0.6	-1.4	-0.2
Fractured/broken bones in last 5 years	0.3	0.4	1.0	-0.4	-0.4	-0.8	0.4	-1.0
Basal cell carcinoma (self-reported)	0.3	0.3	0.5	0.6	0.6	0.7	0.6	-0.2
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.9	0.3	-0.3	-0.4	-0.8	-1.4
Worry (Nagel 2018)	0.2	0.4	1.0	0.8	1.0	0.3	0.4	0.0
Crohns Disease (2017)	0.2	0.4	1.0	0.5	0.1	0.5	1.0	-0.8
Age at First Birth	0.2	0.2	0.5	0.4	-0.4	-0.6	-0.2	-0.7
Primary Biliary Cirrhosis	0.2	0.3	1.1	-1.1	-0.5	-0.3	-0.5	-0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.6	-0.5	0.3	0.7	0.3	0.8
Ulcerative Colitis	0.2	0.3	0.9	-0.0	0.6	0.1	-0.3	1.0
Blood Eosinophil Count	0.2	1.3	2.9	0.8	0.6	1.7	0.0	1.5
Respiratory disease	0.2	0.5	1.3	-0.9	-0.1	-0.1	-1.1	0.4
Chronotype (morning person)	0.2	0.4	1.2	-0.3	-0.7	-0.5	-1.1	0.1
Sensitivity / hurt feelings	0.2	0.3	0.9	-0.3	0.9	0.4	-0.2	0.5
Medication: Co-codamol	0.2	0.2	0.8	0.2	-0.1	-0.1	0.9	0.2
Medication: Metformin	0.2	0.3	1.1	-0.0	-0.4	-0.1	-1.1	0.3
Qualifications: CSEs or equivalent	0.2	0.3	0.7	0.2	0.7	0.8	0.5	0.0
Serious illness, injury or assault to yourself	0.2	0.3	0.8	-0.4	0.4	0.1	-0.5	0.9
Hayfever, allergic rhinitis or eczema	0.2	0.3	1.4	-0.3	-0.0	-0.3	-1.2	0.3
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	0.5	0.7	0.1	0.5	-0.6	0.3
Heart attack	0.2	0.2	0.7	-0.9	-0.4	0.3	-0.1	-0.2
Allergy	0.2	0.4	0.8	0.3	-0.7	0.2	0.7	-0.9
Diabetes (self-reported)	0.2	0.3	1.1	-0.5	-0.2	0.1	-1.0	0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.7	-0.9	0.1	-0.5	-0.2	-0.1
Frequency of tiredness / lethargy in last 2 weeks	0.2	0.3	0.6	0.3	0.5	0.6	0.5	0.8
Medication: Lansoprazole	0.2	0.2	0.5	-0.1	-0.7	0.0	0.2	0.7
Tense / ‘highly strung’	0.2	0.3	1.0	0.1	0.0	0.2	-0.5	1.0
Loud music exposure frequency	0.2	0.2	0.4	-0.5	0.6	0.3	-0.5	-0.0
Medication: Paracetamol	0.2	0.3	0.5	-0.7	0.7	-0.0	-0.3	0.4
Headache pain in last month	0.2	0.3	0.6	-0.8	-0.7	-0.2	-0.6	-0.2
Hypothyroidism/myxoedema (self-reported)	0.2	0.3	0.6	-0.4	0.6	-0.7	-0.3	-0.8
Forced vital capacity (FVC), Best measure	0.2	0.6	1.8	0.2	-0.6	-1.0	-1.4	-0.2
Exposure to tobacco smoke outside home	0.2	0.3	0.7	0.2	0.8	0.8	0.2	0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.6	-0.6	-0.8	-0.5	0.0	-0.1
Shortness of breath walking on level ground	0.2	0.2	0.8	0.9	0.4	0.2	0.0	0.3
Qualifications: College or University degree	0.2	0.6	2.5	-0.1	0.0	-0.7	-1.6	0.1
Emphysema/chronic bronchitis	0.2	0.2	0.3	-0.0	0.5	0.6	0.5	0.3
Medication: Allopurinol	0.2	0.2	0.3	-0.5	-0.0	-0.4	-0.6	0.5
Number of full sisters	0.2	0.2	0.4	-0.6	-0.4	0.0	-0.6	0.4
Suffer from ‘nerves’	0.2	0.3	0.7	0.6	0.7	0.0	0.1	-0.8
Illnesses of siblings: Diabetes	0.2	0.2	0.6	-0.0	0.2	0.8	0.1	0.7
Mood swings	0.2	0.4	0.9	-0.5	0.4	0.3	-1.0	0.7
Loneliness, isolation	0.2	0.3	0.5	-0.2	0.7	0.7	-0.5	0.5
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.4	-0.4	-0.5	-0.4	-0.6	0.2
Asthma (self-reported)	0.2	0.5	0.8	-0.8	0.8	-0.0	-0.5	0.9
Miserableness	0.2	0.4	1.1	-0.1	0.8	0.4	-0.0	1.1
Mother’s age at death	0.2	0.2	0.6	-0.1	0.2	0.5	-0.4	-0.8
Diastolic blood pressure, automated reading	0.2	0.6	2.1	0.3	0.8	0.4	1.4	0.3
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.3	-0.4	-0.1	-0.7	-1.2	-1.0
Cholesterol lowering medication	0.2	0.3	1.0	1.0	0.3	0.3	0.4	-0.4
Pain experienced in last month	0.2	0.4	0.9	0.4	-0.5	0.2	0.8	-1.0
Heart attack/myocardial infarction (self-reported)	0.2	0.2	0.7	-0.8	-0.4	0.3	-0.1	-0.3
Depression (Nagel 2018)	0.1	0.1	0.4	0.1	-0.0	-0.2	-0.3	0.6
HbA1C	0.1	0.1	0.2	0.5	0.3	-0.3	0.1	0.3
Heel T-Score	0.1	1.0	2.7	0.7	0.5	1.1	1.6	0.4
Waist Hip Ratio (WHR)	0.1	0.5	1.5	-0.8	0.3	0.3	-0.3	1.2
Systolic Blood Pressure	0.1	0.5	0.8	-0.8	-0.7	-0.6	0.3	-0.9
Allergy or Eczema	0.1	0.3	0.9	-0.0	-0.2	0.0	-0.9	0.6
Cardiovascular Disease	0.1	0.3	1.0	0.5	0.3	0.2	1.0	0.2
Hypothyroidism (self reported)	0.1	0.1	0.6	-0.1	0.8	-0.2	-0.1	-0.2
Tanning	0.1	1.7	2.3	1.0	1.3	1.5	1.2	1.5
Relative age of first facial hair	0.1	0.3	0.7	-0.0	-0.5	-0.9	-0.4	-0.5
Ever used hormone-replacement therapy (HRT)	0.1	0.1	0.2	-0.3	-0.5	0.2	-0.4	-0.2
Systolic blood pressure, automated reading	0.1	0.2	0.8	-0.2	-0.2	0.4	0.9	0.1
Diabetes (mother)	0.1	0.1	0.2	-0.2	0.4	0.3	-0.0	-0.5
Severe depression (siblings)	0.1	0.1	0.2	0.4	-0.3	-0.3	-0.1	0.4
Pack years adult smoking proportion	0.1	0.1	0.5	-0.2	-0.7	0.1	0.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.2	0.7	-0.0	0.0	-0.1	-0.3	0.9
Relative age voice broke	0.1	0.1	0.2	0.3	-0.3	-0.3	0.1	-0.5
Tinnitus: Yes, but not now, but have in the past	0.1	0.1	0.2	0.1	0.2	0.2	0.5	-0.2
Past tobacco smoking	0.1	0.3	0.5	0.2	0.1	-0.7	0.6	-0.7
Forced vital capacity (FVC)	0.1	0.4	1.2	0.4	-0.4	-0.6	-1.1	-0.5
Neuroticism score	0.1	0.2	0.7	0.1	0.9	0.5	0.0	0.2
Impedance of arm (right)	0.1	0.3	1.3	0.2	0.0	0.0	0.5	-1.1
Hair/balding pattern: Pattern 3	0.1	0.2	0.4	0.4	0.5	0.4	0.6	-0.3
Noisy workplace	0.1	0.2	0.4	-0.7	-0.3	0.0	-0.6	0.1
Qualifications: A levels/AS levels or equivalent	0.1	0.3	0.8	0.9	0.3	0.4	0.0	0.4
Impedance of arm (left)	0.1	0.5	1.4	0.6	0.7	0.6	1.2	-0.0
Breastfed as a baby	0.1	0.1	0.1	-0.3	-0.4	0.4	-0.3	-0.2
Qualifications: O levels/GCSEs or equivalent	0.1	0.2	0.3	-0.1	-0.5	-0.3	0.4	0.5
Mouth/teeth dental problems: Bleeding gums	0.1	0.1	0.2	-0.3	0.4	0.1	-0.4	-0.0
Gout (self-reported)	0.1	0.2	0.5	-0.3	0.1	-0.5	-0.2	0.7
High blood pressure (siblings)	0.1	0.2	0.4	-0.2	-0.4	0.0	0.5	0.6
Health satisfaction	0.1	0.1	0.5	0.2	-0.0	-0.1	-0.7	-0.3
Medication: Blood pressure	0.1	0.1	0.3	-0.5	-0.6	0.1	0.4	-0.2
Mean time to correctly identify matches	0.1	0.1	0.5	0.1	-0.1	-0.1	0.7	-0.2
Pulse rate, automated reading	0.1	0.4	1.1	-0.6	-1.1	-0.6	0.0	-0.2
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.4	0.2	0.7	0.3	0.5	0.3
Hypertension (Self-reported)	0.1	0.4	1.1	0.1	-0.1	0.4	1.1	0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.5	0.1	0.7	0.1	-0.1	0.4
Average weekly red wine intake	0.1	0.2	0.3	0.2	-0.5	-0.4	-0.5	-0.3
Diabetes diagnosed by doctor	0.1	0.2	0.5	-0.0	0.4	0.5	-0.7	0.4
Ever taken oral contraceptive pill	0.1	0.2	0.3	-0.1	-0.5	-0.6	-0.1	-0.4
Hearing aid user	0.1	0.1	0.5	-0.4	-0.1	-0.1	-0.7	0.1
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.4	-0.0	-0.4	-0.3	0.2	0.7
Medication: Atorvastatin	0.1	0.2	0.5	0.2	-0.1	0.7	-0.3	-0.3
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.4	-0.0	-0.1	0.0	-0.6	0.1
Myopia	0.1	0.2	0.4	0.2	0.5	0.3	0.6	0.4
Deep venous thrombosis (DVT) (self-reported)	0.1	0.1	0.2	-0.4	-0.1	-0.4	-0.2	-0.1
Pack years of smoking	0.1	0.1	0.2	0.2	-0.4	0.4	0.4	0.2
Impedance of whole body	0.1	0.3	0.5	0.5	0.5	0.5	0.7	-0.3
Bipolar Disorder (2018)	0.0	0.1	0.1	-0.2	0.4	0.2	0.1	-0.2
Major Depression (MDD)	0.0	0.0	0.1	-0.3	-0.0	-0.0	-0.2	0.2
Bipolar Disorder (2011)	0.0	0.0	0.1	-0.3	0.0	0.0	-0.1	0.0
Coronary Artery Disease (CAD)	0.0	0.1	0.3	-0.5	0.0	0.0	0.2	0.0
Lupus	0.0	0.1	0.2	-0.4	0.2	-0.4	0.0	0.0
Hair Pigment	0.0	0.8	2.7	0.9	-0.0	-0.2	-0.5	-1.6
Impedance of leg (right)	0.0	0.1	0.4	0.2	0.1	0.1	-0.2	-0.6
Fed-up feelings	0.0	0.1	0.2	-0.5	-0.0	0.5	-0.0	-0.1
High blood pressure (mother)	0.0	0.1	0.2	-0.2	-0.1	0.2	0.2	0.4
Impedance of leg (left)	0.0	0.1	0.2	0.4	0.1	0.0	0.0	-0.5
Seen doctor (GP) for nerves, anxiety, tension or depression	0.0	0.0	0.1	-0.1	-0.2	-0.2	-0.4	-0.2
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.2	0.1	-0.2	0.0	-0.1
Birth weight	0.0	0.1	0.2	0.2	-0.1	-0.4	0.2	0.3
Comparative body size at age 10	0.0	0.1	0.1	-0.0	-0.3	-0.0	0.4	-0.4
Number of full brothers	0.0	0.1	0.2	-0.2	0.1	0.1	-0.3	0.4
Age at last live birth	0.0	0.1	0.1	0.2	0.1	0.4	-0.1	0.3

Hub : Genes

TNFRSF10A

Models

Trait associations