Hub : Genes

LPAR1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1698	0.0535	7.1e-05	0.123	NA	0.097	NA	0.114	6.9e-10	NA	5.1e-08	NA	2.9e-09
2	GTEx	Cells EBV-transformed lymphocytes	0.4860	0.1060	2.3e-04	0.024	NA	0.218	NA	0.167	5.6e-02	NA	1.1e-07	NA	4.0e-06
3	GTEx	Cells Transformed fibroblasts	0.3240	0.0660	1.9e-06	0.039	NA	0.101	NA	0.061	6.2e-04	NA	5.6e-08	NA	2.5e-05
4	GTEx	Heart Left Ventricle	0.1411	0.0490	2.6e-03	0.027	NA	0.003	NA	0.007	1.4e-02	NA	2.0e-01	NA	1.3e-01
5	GTEx	Whole Blood	0.0950	0.0330	1.9e-03	0.003	NA	0.001	NA	-0.001	1.5e-01	NA	2.3e-01	NA	3.9e-01
6	METSIM	Adipose	0.0995	0.0262	2.3e-07	0.025	0.051	0.056	0.052	0.042	1.0e-04	4.3e-08	7.4e-09	2.9e-08	5.1e-07
7	NTR	Blood	0.1949	0.0293	0.0e+00	0.073	0.112	0.142	0.139	0.142	1.7e-22	3.2e-34	2.5e-43	1.5e-42	2.1e-43

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.3	0.5	1.1	-0.5	-0.1	-0.5	-1.0	0.6	0.9	0.8
Bipolar Disorder or Schizophrenia	0.2	0.5	1.4	-0.3	0.1	0.3	-0.4	1.2	0.8	0.9
Depressed Affect (Nagel 2018)	0.1	0.3	0.8	-0.2	-0.9	-0.1	0.7	-0.3	-0.2	0.5
Depression (Nagel 2018)	0.2	0.3	1.4	0.7	-0.2	0.1	1.2	-0.6	-0.3	-0.2
Intelligence (Savage-Jansen 2018)	0.4	1.3	5.4	1.1	-0.5	2.3	-0.8	0.8	-0.8	-0.4
Neuroticism (Nagel 2018)	0.1	0.3	0.9	-0.2	-0.5	-0.9	-0.0	0.1	0.7	0.8
Schizophrenia (2018)	0.2	0.3	1.1	0.0	0.2	0.9	0.3	1.0	0.3	0.5
Schizophrenia vs Biploar Disorder	0.5	0.6	1.5	0.9	0.9	0.4	1.2	-0.3	-0.7	-0.8
Worry (Nagel 2018)	0.4	0.9	2.1	-0.6	-0.2	-1.5	0.1	0.5	1.4	1.0
Alzheimer’s Disease (in mother)	0.7	0.8	2.4	-0.0	1.6	0.1	0.7	-1.2	-1.0	-0.7
Alzheimer’s Disease (in father)	1.2	1.3	5.3	2.3	0.8	0.7	0.6	-1.6	-0.2	-0.3
Alzheimer’s Disease (including proxy)	1.1	1.5	2.9	1.5	1.6	0.8	0.8	-1.7	-0.9	-1.0
Crohns Disease (2017)	1.2	2.7	9.6	3.1	0.0	0.7	2.5	-1.0	-1.1	-0.1
Irritable Bowel Disease (IBD)	0.5	1.2	3.5	1.9	-1.2	-0.2	0.6	-1.2	-1.1	-0.7
Ulcerative Colitis (UC)	0.8	1.6	3.3	-0.1	-1.8	-1.4	-1.0	-1.2	-1.1	-1.5
Major Depression (MDD)	0.7	0.8	1.9	1.3	1.1	0.8	1.4	0.2	0.4	-0.2
Reaction Time	0.4	0.8	2.5	1.6	0.2	1.2	1.1	-0.1	0.1	-0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.7	-0.1	-1.7	0.7	-0.4	0.5	-0.7	-0.3
Breast Cancer	0.2	0.4	0.9	-0.4	0.2	-0.6	0.5	-0.6	-0.9	-0.9
Ovarian Cancer	0.3	0.4	1.2	0.6	0.1	-0.2	0.6	1.1	-0.6	0.8
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	0.8	1.1	2.4	1.0	0.1	0.8	0.1	-1.2	-1.5	-1.6
Bipolar Disorder (2011)	0.8	0.7	1.6	-0.9	-0.9	-0.9	-1.3	-0.3	0.9	-0.5
Body Mass Index (BMI) (2010)	0.9	1.3	2.9	-1.2	-0.9	-0.0	-0.9	1.6	0.1	1.7
Coronary Artery Disease (CAD)	2.0	2.4	5.2	-2.3	-1.8	-2.3	-1.1	-0.9	-0.8	-0.6
Crohns Disease (2012)	1.3	2.1	6.9	2.3	1.1	0.5	2.6	0.2	-0.3	0.9
Mean Putamen Volume	1.0	1.1	3.6	-1.0	0.1	-0.4	-0.7	1.0	1.9	1.2
Fasting Glucose	0.3	0.4	1.0	-0.0	-0.6	-0.5	-0.2	-1.0	-0.4	-0.8
HbA1C	1.3	1.4	3.2	-1.0	0.1	-0.7	-1.7	-1.8	-1.0	-1.2
HDL Cholesterol	0.6	1.1	3.5	0.3	1.9	-0.6	0.2	-1.1	-0.9	-1.2
LDL Cholesterol	0.1	0.2	0.5	-0.3	0.1	0.4	-0.4	0.2	0.7	-0.7
Lupus	0.4	0.7	1.8	0.2	0.4	-0.4	-0.6	-1.0	-1.1	-1.3
Neuroticism (2016)	1.3	1.8	5.0	-0.0	-1.2	-0.1	-0.7	1.8	2.2	1.6
Primary Biliary Cirrhosis	1.6	2.3	6.0	2.5	-0.3	2.3	1.4	-0.9	0.3	-1.3
Rheumatoid Arthritis	0.4	0.5	1.2	-0.5	1.0	-0.8	1.1	-0.6	0.5	-0.3
Schizophrenia (2014)	0.1	0.3	1.2	-0.3	-0.2	0.6	-0.0	1.1	0.3	0.4
Triglycerides	1.1	1.9	3.1	1.0	-0.3	1.5	0.9	1.8	1.6	1.8
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.4	0.3	0.1	0.3	0.4	0.1	1.2	1.2
Ulcerative Colitis	0.1	0.1	0.5	0.7	-0.2	-0.2	0.1	0.5	-0.3	0.1
Blood Eosinophil Count	0.9	6.9	16.5	-0.4	-1.6	-2.6	-2.3	3.0	2.9	4.1
Blood Platelet Count	0.2	2.3	6.4	0.1	2.5	-0.6	2.5	-1.8	0.3	-0.5
Blood Red Count	0.1	1.0	3.1	0.1	1.3	-1.8	-0.5	-1.3	0.3	-0.3
Blood White Count	9.8	72.6	196.0	0.4	2.4	-0.9	2.8	11.0	13.3	14.0
Heel T-Score	0.4	3.5	10.4	-1.1	1.3	0.4	-2.7	3.2	1.9	0.6
BMI	0.0	0.3	1.1	-0.6	0.2	-0.1	1.0	0.0	-0.3	-0.4
Height	0.4	8.2	23.5	-3.3	-1.4	0.3	-4.8	0.9	-4.5	0.1
Waist Hip Ratio (WHR)	5.9	26.6	65.6	0.7	-1.6	-1.7	-0.5	-7.8	-8.1	-7.3
Systolic Blood Pressure	1.2	6.3	19.8	-1.0	1.3	-2.9	-0.5	1.7	4.5	3.1
Smoking Status	0.1	0.3	1.1	0.1	0.0	1.0	0.1	-0.1	0.2	0.9
Allergy or Eczema	0.5	1.2	2.6	1.0	-0.6	1.3	0.7	-0.7	-1.6	-1.4
Cardiovascular Disease	0.3	1.0	4.1	-0.3	-0.1	-0.4	0.3	1.3	2.0	1.1
Hypothyroidism (self reported)	1.0	2.3	5.2	-0.2	0.5	1.1	-0.4	2.2	2.1	2.3
Respiratory disease	0.1	0.3	0.8	0.3	0.9	-0.1	-0.1	-0.3	0.6	0.7
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.6	-0.6	-0.3	1.5	0.8	0.6	1.2	1.6
Lung FEV1/FVC ratio	0.6	3.1	10.2	3.2	-1.1	2.7	1.7	0.7	0.2	0.1
Lung FVC	0.5	2.5	9.5	-0.5	-0.9	1.9	1.4	3.1	1.0	0.4
Neuroticism	0.4	1.1	2.6	-1.1	-1.6	-0.6	-0.7	-0.0	1.0	1.3
Chronotype (morning person)	0.2	0.5	1.7	0.6	1.0	0.6	-0.1	-1.3	0.3	0.0
Hair Pigment	0.0	1.4	3.1	1.7	1.8	1.4	1.1	-0.4	0.1	-0.4
Tanning	0.1	1.0	3.2	-0.9	-1.8	-0.2	-0.6	-0.2	-1.2	-0.9
Hand grip strength (left)	0.6	1.5	7.7	0.5	-1.2	2.8	0.2	0.9	-0.0	0.4
Number of treatments/medications taken	1.2	2.1	6.8	-0.7	1.0	-0.3	0.4	2.6	1.8	1.6
Average weekly spirits intake	0.6	0.8	2.2	0.0	1.5	0.2	1.4	0.6	-0.8	-0.2
Sensitivity / hurt feelings	0.3	0.5	1.4	-1.2	-0.6	-0.7	-1.0	-0.0	0.1	0.2
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.5	1.2	-0.0	-0.4	1.6	-0.6	-0.4	0.0
Hearing difficulty/problems: Yes	0.9	1.3	3.8	0.7	-0.1	0.0	0.3	1.8	1.2	1.9
Relative age of first facial hair	0.5	1.0	3.4	0.3	-1.8	0.2	0.4	-0.8	-0.6	-1.6
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.1	0.7	-1.8	0.8	-0.1	0.8	-1.2	-0.6
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.5	1.5	-1.2	2.1	1.2	0.5	0.6	-0.0
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	-0.5	1.0	-0.8	-0.1	-0.7	-0.0	0.3
Systolic blood pressure, automated reading	1.6	4.5	12.2	-0.1	1.8	-1.7	-0.1	2.0	3.5	3.0
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.2	-0.4	0.6	-0.4	0.2	-0.8	-1.1	0.1
Angina	1.0	1.4	4.5	-0.9	-0.6	-0.1	0.5	2.1	1.3	1.4
Medication for hormone replacement therapy	0.8	0.9	1.9	-0.3	-1.3	0.5	-0.9	-1.4	-0.8	-0.9
Vitamin and mineral supplements	1.2	1.6	3.3	-1.4	0.6	-1.7	-0.6	-1.8	-0.8	-1.3
Supplements: Zinc	0.9	1.0	2.4	-0.4	-1.3	0.7	-1.6	1.0	0.6	0.9
Medication: Co-codamol	0.9	1.0	2.2	1.2	0.1	0.8	1.0	1.5	-1.0	0.8
Medication: Metformin	1.0	1.4	3.2	0.2	0.3	1.1	1.3	0.9	1.8	1.8
Diabetes (father)	0.9	1.1	2.4	-1.5	-0.7	0.1	0.9	-0.7	-1.4	-1.2
Diabetes (mother)	0.7	0.9	2.5	-0.5	0.4	-0.8	0.8	0.7	1.6	1.2
Severe depression (siblings)	0.7	0.8	2.8	0.5	-1.4	1.7	-0.2	0.4	-0.0	-0.5
Pack years adult smoking proportion	0.5	0.7	1.7	-0.8	-0.3	-0.5	-1.2	-0.3	0.9	1.3
Impedance of leg (right)	0.2	1.1	1.9	-0.3	1.4	-1.3	0.9	0.6	0.8	1.4
Leg fat-free mass (left)	0.5	2.7	9.1	-2.5	-0.9	0.4	-3.0	0.2	-1.4	-0.8
Trunk fat percentage	0.2	0.9	2.3	-1.5	1.3	-0.3	-0.4	1.1	0.5	0.9
Hand grip strength (right)	0.7	1.8	7.9	0.0	-1.0	2.8	-0.7	1.2	0.8	1.1
Townsend deprivation index at recruitment	0.5	0.7	2.3	0.8	-0.7	0.8	-0.6	0.6	0.4	1.5
Current tobacco smoking	1.0	1.7	6.0	-0.5	-0.3	-0.4	-0.1	-1.7	-2.5	-1.5
Average weekly fortified wine intake	0.6	0.7	2.1	-1.4	0.3	-0.4	-1.0	-0.2	-1.1	-0.7
Maternal smoking around birth	1.0	1.5	4.5	0.2	-1.0	-0.1	-1.6	-0.9	-2.1	-1.2
Fed-up feelings	0.2	0.3	0.6	-0.7	0.0	-0.5	-0.4	-0.7	0.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.3	-0.9	0.6	0.6	-0.6	-0.3	0.1
Relative age voice broke	0.4	0.6	2.5	0.3	-1.0	-0.5	-0.1	-0.2	-0.7	-1.6
Taking other prescription medications	0.7	1.1	2.7	1.0	0.9	1.2	0.7	1.6	0.6	1.1
Age when periods started (menarche)	1.2	2.8	5.5	-2.1	-1.6	-2.3	-0.8	-1.6	1.0	-1.6
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	2.1	-0.4	0.3	0.7	-0.1	-1.5	-0.5	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.6	0.7	0.8	1.2	-1.0	1.9	1.0	0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.3	0.8	0.5	0.3	-0.2	-1.1	-1.0	-0.7
Qualifications: CSEs or equivalent	0.6	0.8	3.1	-1.8	-1.3	-0.7	-0.2	0.1	0.6	0.0
Serious illness, injury or assault to yourself	0.6	0.8	2.1	-0.8	-1.4	-1.0	-1.0	-0.1	-0.6	-0.6
High blood pressure	1.2	3.3	10.2	-0.4	0.6	-0.9	-0.1	2.5	3.2	2.4
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.8	1.1	-0.9	1.1	1.2	-0.4	-1.1	-1.3
Multivitamins +/- minerals	1.7	2.2	7.4	1.7	-0.8	2.7	0.2	1.6	1.0	1.0
Stomach or abdominal pain in last month	1.5	1.9	4.9	-1.1	-0.6	-2.2	0.7	-1.2	-1.8	-1.3
Supplements: Glucosamine	0.7	0.9	3.4	-0.6	-0.2	-0.0	1.3	1.9	0.2	0.6
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.1	1.5	-0.1	1.3	0.9	-0.3	-1.8	-0.9
Medication: Atenolol	1.7	2.1	4.8	0.6	0.5	0.4	1.5	2.2	2.0	1.7
Medication: Levothyroxine sodium	0.7	1.1	2.8	-0.0	1.2	0.5	-0.3	0.8	1.7	1.6
Sitting height	0.5	3.8	12.0	-2.4	-0.9	0.8	-3.5	1.7	-2.1	-0.3
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	0.3	0.1	-0.9	0.8	-0.1	0.0	-0.1
High blood pressure (mother)	0.9	1.3	4.0	-2.0	-0.8	-1.1	-1.7	0.0	0.2	0.6
Body mass index (BMI)	0.1	0.3	1.0	-0.5	0.2	0.1	-0.0	1.0	0.6	0.4
Impedance of leg (left)	0.3	1.3	2.6	-0.1	1.2	-1.3	1.3	0.7	1.1	1.6
Leg predicted mass (left)	0.5	2.8	9.2	-2.6	-0.9	0.4	-3.0	0.2	-1.4	-0.7
Trunk fat mass	0.3	1.3	4.1	-2.0	0.8	-0.5	-1.2	1.4	0.2	0.7
Waist circumference	0.2	0.7	1.6	-1.2	0.1	-0.8	-1.1	-0.3	-0.6	-1.0
Number of incorrect matches in round	0.4	0.7	2.1	1.2	-0.6	-0.3	1.4	-0.5	-0.6	-0.7
Past tobacco smoking	0.6	1.0	3.6	0.0	0.3	-0.7	-0.3	-0.8	-1.9	-1.6
Alcohol usually taken with meals	1.6	2.6	8.0	1.4	0.1	2.8	1.2	1.9	1.6	1.0
Nervous feelings	1.1	2.1	6.2	0.2	-0.0	-1.5	0.6	1.6	2.5	1.8
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.6	0.8	-0.3	0.3	1.2	-1.3	-0.6	-1.0
Hearing difficulty/problems with background noise	0.4	0.6	1.5	1.1	-0.4	0.4	0.0	1.2	0.6	0.9
Hair/balding pattern: Pattern 2	1.8	2.3	5.8	0.2	-0.3	1.3	-1.3	2.0	2.4	1.7
Had menopause	0.1	0.2	0.5	0.2	-0.7	-0.4	0.4	-0.0	-0.5	-0.4
Had other major operations	0.8	1.0	2.5	-1.4	-1.3	-1.6	-0.9	0.0	0.0	-0.2
Forced vital capacity (FVC)	0.6	2.4	5.4	-1.6	-2.2	1.6	-0.8	2.3	-0.9	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.0	0.6	1.2	1.1	-1.3	1.7	0.5	1.1
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.1	-0.1	1.1	0.6	0.0	0.7	0.6	-0.1
Qualifications: None of the above	0.3	0.7	1.5	0.7	0.5	-0.7	0.2	1.0	1.1	1.2
Financial difficulties in last 2 years	0.4	0.6	1.6	0.6	-0.4	1.3	-0.9	-0.1	0.8	0.3
Mouth/teeth dental problems	1.0	1.5	4.6	-0.5	-0.3	-0.2	-1.4	-2.1	-0.5	-1.9
Heart attack	0.8	1.0	3.9	-0.9	-0.2	1.2	0.3	2.0	1.0	-0.2
Allergy	0.2	0.5	1.0	-1.0	-0.1	-0.8	-0.4	0.5	0.8	0.8
Pain all over the body in last month	0.6	0.7	1.5	0.6	0.6	1.1	-1.2	-0.7	-0.1	-0.9
Diabetes (self-reported)	0.6	0.9	3.0	0.3	0.9	1.2	0.7	0.7	0.5	1.7
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.8	-0.8	0.0	-1.9	0.7	0.1	1.2	0.0
Medication: Ramipril	1.4	1.8	6.6	-2.6	0.4	-2.1	-0.1	0.5	1.2	0.2
Medication: Simvastatin	0.7	1.0	2.9	-1.7	0.2	0.3	-1.2	1.1	1.1	0.5
Fluid intelligence score	0.6	1.3	4.1	1.8	-0.9	2.0	0.7	0.2	-0.2	-0.3
Illnesses of siblings	0.8	1.1	2.2	-1.5	-0.1	-0.8	-0.8	-1.4	-0.9	-1.4
Neuroticism score	0.3	0.5	1.3	-0.9	-1.1	-0.8	-0.4	0.1	0.6	0.7
Weight	0.4	1.8	5.0	-2.2	-0.1	-0.1	-2.2	1.5	-0.2	0.5
Impedance of arm (right)	0.1	0.3	1.0	-0.0	0.5	0.4	0.8	-1.0	-0.3	-0.2
Arm fat percentage (right)	0.1	0.2	0.4	-0.4	0.6	0.3	0.6	0.5	0.6	0.1
Trunk fat-free mass	0.4	2.5	10.6	-1.9	-1.1	0.0	-3.2	1.1	-1.1	-0.1
Hip circumference	1.3	5.5	13.5	-1.8	0.3	0.8	-1.5	3.7	3.2	3.0
Time employed in main current job	0.6	0.7	1.8	0.4	1.4	-0.1	1.0	-0.2	-0.7	-1.1
Alcohol intake versus 10 years previously	1.0	1.4	4.8	-0.2	-0.2	1.0	-2.2	-0.5	-1.6	-1.2
Father’s age at death	1.6	2.2	4.6	1.2	-0.6	1.4	-0.5	-2.1	-1.7	-2.0
Worrier / anxious feelings	1.9	3.5	7.6	-2.8	-0.9	-1.5	-2.1	0.9	2.0	2.1
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	6.0	-0.8	0.0	-0.0	-2.5	-0.3	-0.9	0.3
Falls in the last year	1.0	1.4	4.9	0.7	2.2	1.5	0.9	1.1	0.1	0.5
Hair/balding pattern: Pattern 3	0.9	1.3	2.9	-1.2	0.2	-1.0	0.3	-1.6	-1.1	-1.7
Number of live births	1.7	2.4	7.2	-0.4	-0.6	-0.1	-1.3	1.3	2.3	2.7
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.1	-1.1	-2.2	2.1	-0.6	1.9	-0.6	-0.1
Pulse rate	0.3	0.6	1.7	-1.3	0.7	0.7	-0.9	0.1	-0.1	-0.5
Happiness	0.4	0.5	1.1	-1.0	1.1	0.8	-0.1	0.5	-0.1	0.7
Noisy workplace	0.8	1.0	2.6	1.2	0.3	1.2	0.0	-1.1	0.1	-1.6
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.7	-0.4	0.7	1.2	-1.6	0.2	0.3	0.2
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.8	0.4	-0.5	0.5	-0.7	-0.8	-1.3	-1.7
Mouth/teeth dental problems: Dentures	0.2	0.3	1.6	0.0	-0.1	0.0	1.3	0.3	-0.6	0.3
Asthma	0.3	0.5	1.9	1.4	0.5	0.5	-0.2	-0.1	0.4	1.0
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	8.4	-2.9	0.5	-2.0	-1.6	-0.2	-0.1	0.3
Medication: Cholesterol lowering	0.4	0.6	1.5	-1.1	-0.3	0.5	-0.6	1.2	0.9	0.4
Depression (self-reported)	0.3	0.3	0.7	-0.6	-0.3	-0.4	0.3	-0.9	-0.4	-0.9
Medication: Lansoprazole	1.0	1.1	4.2	1.1	1.2	0.6	2.0	-0.0	-0.4	-0.6
Prospective memory result	0.2	0.3	0.9	0.2	-0.9	-0.6	0.6	0.2	0.3	0.4
Lung cancer (father)	1.4	1.6	5.0	-0.4	0.6	-0.4	0.2	1.6	1.8	2.2
Illnesses of mother	0.9	1.1	3.8	1.4	-0.5	0.3	1.9	0.2	0.1	-1.2
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	4.9	-2.2	-1.9	1.2	-1.4	1.6	-0.8	-0.3
Pulse wave Arterial Stiffness index	0.6	0.8	3.7	0.6	0.5	0.4	1.9	-0.2	-0.5	-0.6
Impedance of arm (left)	0.0	0.2	0.4	-0.6	0.5	0.4	-0.1	-0.6	-0.1	-0.0
Arm fat mass (right)	0.1	0.5	1.4	-1.2	-0.0	-0.0	-0.7	1.2	0.3	0.5
Trunk predicted mass	0.4	2.5	10.2	-1.9	-1.1	-0.1	-3.2	1.1	-1.1	-0.2
Standing height	0.7	6.7	24.2	-4.0	-0.9	-0.5	-4.9	1.5	-1.8	0.5
Length of working week for main job	0.3	0.3	0.7	-0.7	0.4	-0.3	-0.8	-0.6	0.1	-0.5
Exposure to tobacco smoke at home	1.1	1.2	4.2	0.2	-1.2	-0.9	2.0	-0.5	-1.1	-0.8
Breastfed as a baby	0.6	0.8	2.2	-0.8	-0.0	0.9	-0.6	1.5	0.9	0.7
Tense / ‘highly strung’	0.3	0.6	3.4	-0.1	1.8	-0.5	0.2	0.1	0.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.6	-0.3	-1.0	0.0	0.1	-0.4	0.4
Hair/balding pattern: Pattern 4	0.2	0.4	1.6	0.4	-1.3	-0.6	0.3	-0.0	0.6	-0.3
Birth weight of first child	5.2	9.5	24.3	-3.0	-0.2	-1.4	-2.6	-3.4	-4.9	-3.5
Peak expiratory flow (PEF)	0.6	1.3	4.5	-0.2	-1.5	2.1	0.1	1.3	0.7	0.5
Pulse wave reflection index	0.2	0.2	0.6	0.3	0.8	0.1	0.5	-0.4	-0.7	-0.2
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.8	-0.1	0.1	-0.5	-0.8	0.7	0.5	0.9
Loud music exposure frequency	0.2	0.2	0.4	0.3	-0.3	0.5	0.2	0.6	-0.6	0.0
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.3	-1.8	0.6	-0.1	-1.6	-1.3	-0.3	-0.8
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	0.4	-0.6	0.2	0.9	-0.1	0.3	0.6
Blood clot in the leg (DVT)	0.4	0.5	1.3	-0.7	0.7	-0.7	-1.1	0.6	0.5	-0.1
Medication: Paracetamol	0.5	0.9	2.3	-1.5	-0.1	-1.1	-1.0	1.1	0.0	0.4
Headache pain in last month	0.6	1.1	3.7	-1.8	0.1	-1.9	-0.6	0.2	-0.4	0.4
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	5.5	-0.1	-0.3	-0.3	-0.6	-2.3	-2.1	-1.9
Glaucoma (self-reported)	0.2	0.2	0.4	0.2	0.5	0.3	-0.6	0.6	0.2	0.2
Gout (self-reported)	1.6	2.2	6.1	0.2	0.6	-0.3	0.3	-2.5	-2.0	-2.2
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	5.0	0.2	0.3	0.8	-0.0	1.7	1.8	2.2
Medication: Amlodipine	1.2	1.6	4.3	-0.2	1.0	-0.4	-0.2	2.0	2.1	1.3
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.5	1.3	1.6	0.9	-0.9	0.6	1.5	0.4
Birth weight	1.8	3.8	8.6	-0.9	-0.4	0.9	-2.6	-2.1	-2.9	-2.3
Chronic bronchitis/emphysema (mother)	1.1	1.2	3.2	-0.1	-0.4	-1.6	0.7	1.3	0.7	1.8
High blood pressure (siblings)	0.5	0.8	1.5	0.6	1.1	0.3	0.7	0.8	1.2	1.1
Forced vital capacity (FVC), Best measure	0.8	3.1	6.5	-2.6	-1.6	1.6	-2.2	2.1	-0.8	0.1
Body fat percentage	0.2	0.8	1.5	-1.2	1.2	-0.3	0.1	1.1	0.8	0.8
Leg fat percentage (right)	0.3	1.2	2.5	-0.8	1.6	-0.6	0.7	1.3	1.1	1.2
Arm fat-free mass (right)	0.6	3.2	12.0	-2.6	-0.3	-0.6	-3.5	1.6	-0.5	0.4
Exposure to tobacco smoke outside home	2.5	3.3	9.5	-0.5	-2.3	-0.1	0.0	3.1	1.7	2.3
Comparative body size at age 10	1.4	3.9	11.0	0.7	0.7	0.2	1.0	-2.1	-3.1	-3.3
Number of full brothers	1.0	1.2	3.6	-1.2	0.4	-0.7	-1.9	-0.7	-1.6	-0.2
Worry too long after embarrassment	0.1	0.2	0.7	0.1	0.4	-0.8	-0.2	0.0	0.4	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.2	1.5	-1.5	0.9	0.9	-0.2	-0.3	-0.2
Wheeze or whistling in the chest in last year	0.4	0.6	1.8	0.6	-0.5	-0.6	-0.3	1.2	0.3	1.3
Number of children fathered	1.2	1.3	5.5	1.6	0.8	0.0	2.3	-0.7	0.2	-0.0
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	7.1	2.4	0.8	2.7	1.3	1.6	1.1	1.2
Age at first live birth	0.4	0.6	1.8	-1.1	1.3	0.5	-0.9	0.2	-0.1	-0.6
Pulse wave peak to peak time	1.0	1.2	6.2	-0.9	-0.6	-0.4	-2.5	0.3	0.1	0.7
Health satisfaction	0.5	0.6	2.1	0.7	0.2	-0.4	1.4	-0.6	-1.1	0.0
Shortness of breath walking on level ground	0.5	0.6	1.2	-0.0	1.1	-0.3	0.7	0.8	-1.0	-0.9
Qualifications: College or University degree	1.2	3.7	10.7	0.9	0.0	-0.3	0.6	-2.9	-2.4	-3.3
Eye problems/disorders: None of the above	0.9	1.0	3.3	-1.8	-0.8	-1.0	-1.0	0.2	1.0	0.3
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.9	1.4	0.2	0.6	0.7	-0.2	0.1	0.1
Emphysema/chronic bronchitis	1.0	1.1	4.0	-0.7	2.0	-1.0	0.3	-0.1	1.0	1.2
Medication for pain relief, constipation, heartburn	0.4	0.8	3.0	1.7	-0.2	0.0	1.0	-1.0	-0.5	-0.0
Neck or shoulder pain in last month	0.8	1.1	2.8	-0.3	1.7	-1.6	0.3	-1.2	-0.4	-0.4
Medication: Blood pressure	2.0	3.6	8.3	-0.1	1.2	-0.6	0.4	2.9	2.8	2.7
Angina (self-reported)	1.1	1.5	5.0	-0.8	-0.6	-0.1	0.3	2.2	1.4	1.5
Migraine (self-reported)	0.8	0.9	3.5	-0.3	1.9	-0.6	-0.0	0.9	0.2	1.3
Medication: Ibuprofen	1.1	1.3	5.6	-2.4	-0.3	-0.9	-1.5	0.1	0.0	0.1
Medication: Allopurinol	0.7	1.0	3.7	0.3	0.5	-0.6	0.8	-1.9	-0.5	-1.2
Medication: Omeprazole	0.7	0.8	2.7	-1.6	0.3	-1.1	-1.0	0.4	-0.3	0.3
Medication: Seretide 50 evohaler	0.3	0.3	0.8	0.4	0.3	-0.8	0.6	-0.9	-0.3	-0.3
Mean time to correctly identify matches	0.9	1.7	3.8	2.0	1.1	0.8	1.4	1.4	1.2	0.8
Heart disease (mother)	1.6	2.0	6.3	0.4	-0.6	0.3	0.1	2.2	1.5	2.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.0	-0.1	1.1	-1.1	-0.0	0.2	1.7	1.0
Whole body fat mass	0.2	0.9	2.4	-1.6	0.5	-0.3	-0.7	1.5	0.6	0.9
Leg fat mass (right)	0.2	0.9	2.6	-1.6	0.6	-0.6	-0.3	1.3	0.4	0.8
Arm predicted mass (right)	0.6	3.0	11.6	-2.5	-0.5	-0.6	-3.4	1.5	-0.5	0.3
Pulse rate, automated reading	0.6	1.8	3.7	0.1	1.8	0.3	-1.1	-1.9	-1.5	-1.5
Alcohol intake frequency.	0.2	0.4	1.4	-1.1	0.4	-1.2	0.2	-0.3	-0.5	-0.2
Comparative height size at age 10	0.7	3.8	11.1	-0.8	0.9	1.2	-1.3	3.3	0.8	3.3
Number of full sisters	1.8	2.2	4.2	-1.2	-0.9	-1.7	-1.4	0.5	2.0	2.0
Suffer from ‘nerves’	0.6	0.9	3.0	0.9	-0.5	-0.0	1.0	0.6	1.7	0.9
Overall health rating	0.4	0.8	3.9	-0.2	-0.5	-0.2	-0.3	1.1	-0.2	2.0
Chest pain or discomfort	0.9	1.3	2.9	0.9	0.7	1.7	1.0	0.9	1.1	1.5
Had major operations	0.5	0.6	2.1	-0.5	0.9	-0.7	0.5	0.2	0.6	1.5
Age at last live birth	1.0	1.5	3.7	-0.9	0.0	0.6	-0.5	1.9	1.8	1.5
Family relationship satisfaction	0.5	0.7	1.5	1.1	-0.8	0.9	1.2	-0.4	-0.3	0.1
Leg pain on walking	0.6	0.7	3.5	1.9	0.1	0.5	1.0	0.3	-0.1	0.1
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	-0.7	-0.4	0.8	-0.8	0.7	-0.2	1.2
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.1	-1.0	-0.4	-0.2	-0.7	-0.3	-0.5	-0.7
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	4.0	-0.8	2.0	-0.8	1.0	0.0	0.1	-0.1
Medication: Aspirin	1.6	2.1	6.4	0.6	0.5	2.5	0.6	2.3	1.2	1.0
Supplements: Vitamin C	0.2	0.3	0.4	0.6	-0.5	0.7	-0.2	0.5	-0.6	0.4
Knee pain experienced in last month	1.2	1.8	5.8	-1.7	-0.8	-2.4	0.6	1.5	-0.1	0.9
Hypertension (Self-reported)	1.1	3.1	9.8	-0.5	0.1	-1.2	-0.1	2.4	3.1	2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.9	0.1	-0.3	-0.2	0.8	0.1	0.1	-1.0
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.9	0.1	0.7	-0.8	0.7	0.0	0.8
Illnesses of siblings: Diabetes	0.6	0.7	1.8	-0.0	-0.8	-0.2	-0.4	1.3	1.2	1.0
Smoking status: Previous	1.6	2.3	7.1	0.4	-0.1	1.1	0.4	1.6	2.7	2.2
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	8.1	-2.7	-0.8	0.2	-2.9	-0.1	-1.0	-0.2
Whole body fat-free mass	0.5	2.7	10.6	-2.3	-1.0	0.1	-3.2	0.8	-1.2	-0.3
Leg fat-free mass (right)	0.5	2.8	9.7	-2.4	-1.0	0.7	-3.1	0.1	-1.5	-0.8
Arm fat percentage (left)	0.1	0.3	0.8	-0.9	0.4	0.3	-0.1	0.7	0.8	0.1
Average weekly red wine intake	0.1	0.1	0.5	-0.3	-0.7	0.3	0.1	-0.1	0.0	-0.3
Handedness (chirality/laterality): Left-handed	1.3	1.5	4.9	1.5	-0.4	1.4	2.2	0.6	1.0	0.2
Mood swings	0.3	0.5	1.2	0.8	-0.8	1.1	0.8	-0.2	-0.2	-0.0
Loneliness, isolation	0.8	1.1	2.4	-1.4	-1.2	0.1	0.1	1.6	0.9	0.9
Long-standing illness, disability or infirmity	1.4	2.1	5.1	1.4	0.4	1.5	0.5	2.3	0.5	2.2
Ever had bowel cancer screening	0.2	0.3	0.8	0.1	0.3	-0.3	-0.8	0.4	-0.3	-0.9
Diabetes diagnosed by doctor	1.1	1.9	6.1	0.4	0.3	1.7	0.5	1.4	1.4	2.5
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	5.0	1.6	-0.7	1.4	1.5	2.2	0.9	1.8
Friendships satisfaction	0.3	0.4	1.3	-0.6	-0.5	-0.2	-0.2	-0.8	-1.2	-0.4
Qualifications: nursing, teaching	0.1	0.2	0.5	0.4	-0.3	0.1	0.7	-0.4	0.5	0.7
Commuting to job workplace: Walk	0.6	0.7	1.9	-0.3	-0.1	0.3	-0.1	1.3	1.4	1.0
Eye problems/disorders: Cataract	0.6	0.7	3.0	1.1	-0.4	0.2	1.7	0.4	-0.4	0.2
Mouth/teeth dental problems: Mouth ulcers	2.3	3.6	7.6	-0.2	1.5	-0.5	-1.1	2.7	2.7	2.8
Medication for cholesterol	0.1	0.1	0.3	0.3	-0.4	-0.3	0.5	0.1	0.5	0.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	3.9	0.2	0.7	0.1	2.0	1.4	0.1	0.2
Back pain experienced in last month	0.3	0.5	1.5	0.3	-0.5	1.0	-0.3	1.2	-0.6	0.3
Mineral and other dietary supplements	2.7	3.6	10.8	-1.2	-1.2	-1.1	-1.1	-3.3	-2.0	-2.3
Breast cancer (self-reported)	0.4	0.5	2.3	-0.5	-0.0	0.5	0.1	-1.0	0.1	-1.5
Asthma (self-reported)	0.3	0.7	2.6	1.6	0.5	0.7	0.0	0.0	0.4	1.1
Osteoporosis (self-reported)	1.5	1.9	4.9	1.7	0.9	0.2	1.2	-1.0	-2.2	-1.4
Osteoarthritis (self-reported)	0.5	0.7	1.4	-0.6	-1.1	-0.6	0.6	1.1	-1.2	0.1
Medication: Aspirin	1.2	1.6	5.1	0.6	0.5	2.3	0.5	1.8	1.2	0.9
Medication: Gliclazide	0.2	0.3	0.5	-0.7	-0.6	0.1	0.6	0.4	0.6	0.1
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	-0.0	0.2	-0.3	-0.4	-0.6	-0.2	-0.3
Smoking status: Current	1.1	1.7	6.2	-0.3	-0.2	-0.1	-0.0	-1.8	-2.5	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	7.6	0.7	-0.3	2.7	0.7	2.1	0.2	0.8
Whole body water mass	0.5	2.9	11.3	-2.4	-1.2	0.0	-3.4	0.8	-1.2	-0.5
Leg predicted mass (right)	0.5	2.8	9.4	-2.4	-1.0	0.7	-3.1	0.0	-1.6	-0.8
Arm fat mass (left)	0.2	0.8	2.2	-1.5	0.1	-0.2	-1.0	1.3	0.5	0.5
Number of self-reported non-cancer illnesses	2.0	3.5	8.4	1.6	-0.1	0.7	0.5	2.9	2.4	2.7
Average weekly champagne plus white wine intake	0.1	0.2	1.0	-0.4	-0.1	-0.1	-0.4	-0.0	0.3	-1.0
Miserableness	0.3	0.6	1.0	-0.9	-0.9	-1.0	-0.5	-0.0	-0.8	0.7
Guilty feelings	0.5	0.8	2.4	-1.0	-0.6	-1.5	-0.3	0.4	0.4	1.1
Wears glasses or contact lenses	1.0	1.2	4.2	1.2	2.0	0.7	0.4	0.5	1.1	0.8
Ever taken oral contraceptive pill	0.7	0.8	1.4	-0.1	-1.1	1.1	-0.6	1.2	0.7	0.9
Hearing aid user	0.6	0.7	3.0	-0.5	-0.3	-0.5	1.0	-0.6	-1.7	0.2
Mother’s age at death	0.5	0.6	2.6	-1.0	0.2	-1.6	0.6	-0.2	-0.4	0.1
Financial situation satisfaction	0.9	1.1	4.9	0.3	-2.2	0.8	0.1	0.6	-1.3	0.5
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.4	1.8	1.1	1.4	0.9	0.7	0.3	0.4
Commuting to job workplace: Public transport	0.7	0.8	2.0	0.9	1.3	1.4	0.6	-0.3	0.6	0.0
Eye problems/disorders: Glaucoma	0.3	0.4	0.8	0.4	0.3	0.9	-0.9	0.2	-0.8	-0.3
Medication: Blood pressure	0.5	0.9	2.3	0.2	0.8	0.7	0.2	1.5	1.4	0.7
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.2	-0.1	-0.1	-0.4	0.5	0.0	-0.0	-0.2
Supplements: Fish oil (including cod liver oil)	0.9	1.2	3.7	1.2	0.2	1.1	0.1	1.9	0.9	1.0
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.7	0.6	0.1	0.1	-0.2	0.5	0.1
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.0	0.8	0.4	-0.1	0.4	0.8	0.2
Medication: Paracetamol	0.4	0.7	2.3	-0.8	-0.2	-0.8	-0.4	1.5	0.3	0.9
Medication: Lisinopril	1.8	2.3	5.1	0.4	1.6	0.6	1.9	1.7	2.3	1.2
Medication: Atorvastatin	0.8	1.0	2.5	0.2	-0.6	0.5	1.6	1.4	0.9	0.9
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.3	0.6	0.8	0.3	0.1	-0.3	-0.1
Alcohol drinker status: Never	1.2	1.5	3.9	-2.0	-0.6	-1.8	-0.1	-0.6	-1.1	-1.2
Ever smoked	0.5	0.8	2.5	-0.5	-0.6	-0.1	-0.0	0.5	1.6	1.5
Basal metabolic rate	0.5	2.6	10.0	-2.3	-0.8	0.1	-3.2	1.0	-1.0	-0.1
Leg fat percentage (left)	0.3	1.2	1.9	-0.5	1.4	-0.5	0.8	1.4	1.3	1.2
Arm fat-free mass (left)	0.4	2.1	8.0	-1.9	-0.6	-0.3	-2.8	1.5	-0.7	0.2
Number of operations (self-reported)	0.8	1.1	4.3	-1.7	-0.4	-2.1	0.3	0.2	0.3	0.5
Average weekly beer plus cider intake	0.6	0.9	3.6	0.3	0.7	0.3	0.3	0.9	0.9	1.9
Irritability	0.2	0.4	0.8	0.9	0.2	0.7	0.8	-0.4	-0.4	-0.5
Risk taking	0.7	1.0	3.5	-0.7	0.7	-0.5	-1.9	-0.3	-1.0	-1.1
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.5	-0.4	-1.0	-1.8	0.2	-1.3	-1.9	-1.1
Fractured/broken bones in last 5 years	0.8	1.1	3.9	0.5	0.5	-0.2	0.8	-1.2	-1.0	-2.0
Age started oral contraceptive pill	0.7	0.9	2.5	-1.0	-0.3	-0.9	0.1	1.6	1.1	1.0
Diastolic blood pressure, automated reading	0.7	2.3	6.9	-0.7	2.6	-1.6	-0.4	1.1	1.4	1.5
Ever depressed for a whole week	0.3	0.4	0.8	0.0	0.1	0.7	0.9	0.9	0.1	0.8
Unable to work because of sickness or disability	0.6	0.7	1.5	1.2	0.0	1.2	0.7	0.7	-0.4	1.0
Commuting to job workplace: Cycle	0.6	0.7	2.7	-0.2	-0.1	0.0	1.6	1.2	-0.6	0.6
Myopia	0.3	0.4	1.1	-0.9	0.2	-0.5	-1.0	-0.5	0.5	0.1
Vascular/heart problems diagnosed by doctor	1.5	4.0	11.7	0.8	-0.5	0.8	0.5	-2.9	-3.4	-2.5
Cholesterol lowering medication	0.2	0.3	0.9	-0.8	0.9	0.1	-0.4	0.4	0.2	0.2
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.4	-1.6	0.1	-0.9	-0.6	0.6	-0.0	0.0
Pain experienced in last month	0.2	0.3	0.5	0.7	0.5	0.4	0.2	0.7	0.7	0.4
Supplements: Calcium	0.6	0.6	1.7	0.9	-0.2	1.0	-0.1	1.3	0.8	0.3
Basal cell carcinoma (self-reported)	0.2	0.3	1.3	-1.1	-0.6	-0.2	0.0	-0.2	0.0	-0.4
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.8	-0.8	-0.3	1.0	0.4	1.7	0.6	-0.5
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-0.6	0.8	-0.9	-1.1	0.5	0.4	-0.2
Heart disease (siblings)	1.0	1.2	3.9	-0.3	0.4	0.5	0.4	1.8	0.9	2.0
Alcohol drinker status: Previous	2.1	2.4	6.9	1.4	0.7	0.5	2.6	1.5	0.8	2.0
Pack years of smoking	0.5	0.7	1.7	-0.9	0.2	-0.3	-1.3	-0.1	0.9	1.3
Impedance of whole body	0.1	0.5	1.7	-0.6	1.3	-0.7	0.5	0.0	0.4	0.9
Leg fat mass (left)	0.2	0.8	2.1	-1.5	0.5	-0.5	-0.2	1.4	0.6	0.8
Arm predicted mass (left)	0.5	2.5	9.1	-2.3	-0.7	-0.8	-3.0	1.4	-0.6	0.2