TWAS hub - LPAR1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1698	0.0535	7.1e-05	0.123	NA	0.097	NA	0.114	6.9e-10	NA	5.1e-08	NA	2.9e-09
2	GTEx	Cells EBV-transformed lymphocytes	0.4860	0.1060	2.3e-04	0.024	NA	0.218	NA	0.167	5.6e-02	NA	1.1e-07	NA	4.0e-06
3	GTEx	Cells Transformed fibroblasts	0.3240	0.0660	1.9e-06	0.039	NA	0.101	NA	0.061	6.2e-04	NA	5.6e-08	NA	2.5e-05
4	GTEx	Heart Left Ventricle	0.1411	0.0490	2.6e-03	0.027	NA	0.003	NA	0.007	1.4e-02	NA	2.0e-01	NA	1.3e-01
5	GTEx	Whole Blood	0.0950	0.0330	1.9e-03	0.003	NA	0.001	NA	-0.001	1.5e-01	NA	2.3e-01	NA	3.9e-01
6	METSIM	Adipose	0.0995	0.0262	2.3e-07	0.025	0.051	0.056	0.052	0.042	1.0e-04	4.3e-08	7.4e-09	2.9e-08	5.1e-07
7	NTR	Blood	0.1949	0.0293	0.0e+00	0.073	0.112	0.142	0.139	0.142	1.7e-22	3.2e-34	2.5e-43	1.5e-42	2.1e-43

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Blood White Count	9.8	72.6	196.0	0.4	2.4	-0.9	2.8	11.0	13.3	14.0
Waist Hip Ratio (WHR)	5.9	26.6	65.6	0.7	-1.6	-1.7	-0.5	-7.8	-8.1	-7.3
Birth weight of first child	5.2	9.5	24.3	-3.0	-0.2	-1.4	-2.6	-3.4	-4.9	-3.5
Mineral and other dietary supplements	2.7	3.6	10.8	-1.2	-1.2	-1.1	-1.1	-3.3	-2.0	-2.3
Exposure to tobacco smoke outside home	2.5	3.3	9.5	-0.5	-2.3	-0.1	0.0	3.1	1.7	2.3
Reason for reducing amount of alcohol drunk: Health precaution	2.5	2.9	7.1	2.4	0.8	2.7	1.3	1.6	1.1	1.2
Mouth/teeth dental problems: Mouth ulcers	2.3	3.6	7.6	-0.2	1.5	-0.5	-1.1	2.7	2.7	2.8
Ever had stillbirth, spontaneous miscarriage or termination	2.2	2.3	5.0	1.6	-0.7	1.4	1.5	2.2	0.9	1.8
Alcohol drinker status: Previous	2.1	2.4	6.9	1.4	0.7	0.5	2.6	1.5	0.8	2.0
Coronary Artery Disease (CAD)	2.0	2.4	5.2	-2.3	-1.8	-2.3	-1.1	-0.9	-0.8	-0.6
Medication: Blood pressure	2.0	3.6	8.3	-0.1	1.2	-0.6	0.4	2.9	2.8	2.7
Number of self-reported non-cancer illnesses	2.0	3.5	8.4	1.6	-0.1	0.7	0.5	2.9	2.4	2.7
Worrier / anxious feelings	1.9	3.5	7.6	-2.8	-0.9	-1.5	-2.1	0.9	2.0	2.1
Hair/balding pattern: Pattern 2	1.8	2.3	5.8	0.2	-0.3	1.3	-1.3	2.0	2.4	1.7
Birth weight	1.8	3.8	8.6	-0.9	-0.4	0.9	-2.6	-2.1	-2.9	-2.3
Number of full sisters	1.8	2.2	4.2	-1.2	-0.9	-1.7	-1.4	0.5	2.0	2.0
Medication: Lisinopril	1.8	2.3	5.1	0.4	1.6	0.6	1.9	1.7	2.3	1.2
Multivitamins +/- minerals	1.7	2.2	7.4	1.7	-0.8	2.7	0.2	1.6	1.0	1.0
Medication: Atenolol	1.7	2.1	4.8	0.6	0.5	0.4	1.5	2.2	2.0	1.7
Number of live births	1.7	2.4	7.2	-0.4	-0.6	-0.1	-1.3	1.3	2.3	2.7
Medication: Ibuprofen (e.g. Nurofen)	1.7	2.2	8.4	-2.9	0.5	-2.0	-1.6	-0.2	-0.1	0.3
Primary Biliary Cirrhosis	1.6	2.3	6.0	2.5	-0.3	2.3	1.4	-0.9	0.3	-1.3
Systolic blood pressure, automated reading	1.6	4.5	12.2	-0.1	1.8	-1.7	-0.1	2.0	3.5	3.0
Alcohol usually taken with meals	1.6	2.6	8.0	1.4	0.1	2.8	1.2	1.9	1.6	1.0
Father’s age at death	1.6	2.2	4.6	1.2	-0.6	1.4	-0.5	-2.1	-1.7	-2.0
Gout (self-reported)	1.6	2.2	6.1	0.2	0.6	-0.3	0.3	-2.5	-2.0	-2.2
Heart disease (mother)	1.6	2.0	6.3	0.4	-0.6	0.3	0.1	2.2	1.5	2.5
Medication: Aspirin	1.6	2.1	6.4	0.6	0.5	2.5	0.6	2.3	1.2	1.0
Smoking status: Previous	1.6	2.3	7.1	0.4	-0.1	1.1	0.4	1.6	2.7	2.2
Stomach or abdominal pain in last month	1.5	1.9	4.9	-1.1	-0.6	-2.2	0.7	-1.2	-1.8	-1.3
Osteoporosis (self-reported)	1.5	1.9	4.9	1.7	0.9	0.2	1.2	-1.0	-2.2	-1.4
Vascular/heart problems diagnosed by doctor	1.5	4.0	11.7	0.8	-0.5	0.8	0.5	-2.9	-3.4	-2.5
Medication: Ramipril	1.4	1.8	6.6	-2.6	0.4	-2.1	-0.1	0.5	1.2	0.2
Lung cancer (father)	1.4	1.6	5.0	-0.4	0.6	-0.4	0.2	1.6	1.8	2.2
Comparative body size at age 10	1.4	3.9	11.0	0.7	0.7	0.2	1.0	-2.1	-3.1	-3.3
Long-standing illness, disability or infirmity	1.4	2.1	5.1	1.4	0.4	1.5	0.5	2.3	0.5	2.2
Ever had prostate specific antigen (PSA) test	1.4	1.6	3.5	-0.4	-1.0	-1.8	0.2	-1.3	-1.9	-1.1
Crohns Disease (2012)	1.3	2.1	6.9	2.3	1.1	0.5	2.6	0.2	-0.3	0.9
HbA1C	1.3	1.4	3.2	-1.0	0.1	-0.7	-1.7	-1.8	-1.0	-1.2
Neuroticism (2016)	1.3	1.8	5.0	-0.0	-1.2	-0.1	-0.7	1.8	2.2	1.6
Hip circumference	1.3	5.5	13.5	-1.8	0.3	0.8	-1.5	3.7	3.2	3.0
Handedness (chirality/laterality): Left-handed	1.3	1.5	4.9	1.5	-0.4	1.4	2.2	0.6	1.0	0.2
Alzheimer’s Disease (in father)	1.2	1.3	5.3	2.3	0.8	0.7	0.6	-1.6	-0.2	-0.3
Crohns Disease (2017)	1.2	2.7	9.6	3.1	0.0	0.7	2.5	-1.0	-1.1	-0.1
Systolic Blood Pressure	1.2	6.3	19.8	-1.0	1.3	-2.9	-0.5	1.7	4.5	3.1
Number of treatments/medications taken	1.2	2.1	6.8	-0.7	1.0	-0.3	0.4	2.6	1.8	1.6
Vitamin and mineral supplements	1.2	1.6	3.3	-1.4	0.6	-1.7	-0.6	-1.8	-0.8	-1.3
Age when periods started (menarche)	1.2	2.8	5.5	-2.1	-1.6	-2.3	-0.8	-1.6	1.0	-1.6
High blood pressure	1.2	3.3	10.2	-0.4	0.6	-0.9	-0.1	2.5	3.2	2.4
Medication for cholesterol, blood pressure or diabetes	1.2	2.0	5.5	-0.1	-0.3	-0.3	-0.6	-2.3	-2.1	-1.9
Medication: Amlodipine	1.2	1.6	4.3	-0.2	1.0	-0.4	-0.2	2.0	2.1	1.3
Number of children fathered	1.2	1.3	5.5	1.6	0.8	0.0	2.3	-0.7	0.2	-0.0
Qualifications: College or University degree	1.2	3.7	10.7	0.9	0.0	-0.3	0.6	-2.9	-2.4	-3.3
Knee pain experienced in last month	1.2	1.8	5.8	-1.7	-0.8	-2.4	0.6	1.5	-0.1	0.9
Forced expiratory volume in 1-second (FEV1), predicted	1.2	2.5	8.1	-2.7	-0.8	0.2	-2.9	-0.1	-1.0	-0.2
Medication: Aspirin	1.2	1.6	5.1	0.6	0.5	2.3	0.5	1.8	1.2	0.9
Alcohol drinker status: Never	1.2	1.5	3.9	-2.0	-0.6	-1.8	-0.1	-0.6	-1.1	-1.2
Alzheimer’s Disease (including proxy)	1.1	1.5	2.9	1.5	1.6	0.8	0.8	-1.7	-0.9	-1.0
Triglycerides	1.1	1.9	3.1	1.0	-0.3	1.5	0.9	1.8	1.6	1.8
Ever used hormone-replacement therapy (HRT)	1.1	1.4	4.5	1.5	-1.2	2.1	1.2	0.5	0.6	-0.0
Diverticular disease/diverticulitis (self-reported)	1.1	1.3	3.1	1.5	-0.1	1.3	0.9	-0.3	-1.8	-0.9
Nervous feelings	1.1	2.1	6.2	0.2	-0.0	-1.5	0.6	1.6	2.5	1.8
Exposure to tobacco smoke at home	1.1	1.2	4.2	0.2	-1.2	-0.9	2.0	-0.5	-1.1	-0.8
Chronic bronchitis/emphysema (mother)	1.1	1.2	3.2	-0.1	-0.4	-1.6	0.7	1.3	0.7	1.8
Angina (self-reported)	1.1	1.5	5.0	-0.8	-0.6	-0.1	0.3	2.2	1.4	1.5
Medication: Ibuprofen	1.1	1.3	5.6	-2.4	-0.3	-0.9	-1.5	0.1	0.0	0.1
Hypertension (Self-reported)	1.1	3.1	9.8	-0.5	0.1	-1.2	-0.1	2.4	3.1	2.1
Diabetes diagnosed by doctor	1.1	1.9	6.1	0.4	0.3	1.7	0.5	1.4	1.4	2.5
Smoking status: Current	1.1	1.7	6.2	-0.3	-0.2	-0.1	-0.0	-1.8	-2.5	-1.5
Mean Putamen Volume	1.0	1.1	3.6	-1.0	0.1	-0.4	-0.7	1.0	1.9	1.2
Hypothyroidism (self reported)	1.0	2.3	5.2	-0.2	0.5	1.1	-0.4	2.2	2.1	2.3
Angina	1.0	1.4	4.5	-0.9	-0.6	-0.1	0.5	2.1	1.3	1.4
Medication: Metformin	1.0	1.4	3.2	0.2	0.3	1.1	1.3	0.9	1.8	1.8
Current tobacco smoking	1.0	1.7	6.0	-0.5	-0.3	-0.4	-0.1	-1.7	-2.5	-1.5
Maternal smoking around birth	1.0	1.5	4.5	0.2	-1.0	-0.1	-1.6	-0.9	-2.1	-1.2
Mouth/teeth dental problems	1.0	1.5	4.6	-0.5	-0.3	-0.2	-1.4	-2.1	-0.5	-1.9
Alcohol intake versus 10 years previously	1.0	1.4	4.8	-0.2	-0.2	1.0	-2.2	-0.5	-1.6	-1.2
Falls in the last year	1.0	1.4	4.9	0.7	2.2	1.5	0.9	1.1	0.1	0.5
Medication: Lansoprazole	1.0	1.1	4.2	1.1	1.2	0.6	2.0	-0.0	-0.4	-0.6
Medication: Ventolin 100micrograms inhaler	1.0	1.2	2.5	1.3	1.6	0.9	-0.9	0.6	1.5	0.4
Number of full brothers	1.0	1.2	3.6	-1.2	0.4	-0.7	-1.9	-0.7	-1.6	-0.2
Pulse wave peak to peak time	1.0	1.2	6.2	-0.9	-0.6	-0.4	-2.5	0.3	0.1	0.7
Emphysema/chronic bronchitis	1.0	1.1	4.0	-0.7	2.0	-1.0	0.3	-0.1	1.0	1.2
Age at last live birth	1.0	1.5	3.7	-0.9	0.0	0.6	-0.5	1.9	1.8	1.5
Wears glasses or contact lenses	1.0	1.2	4.2	1.2	2.0	0.7	0.4	0.5	1.1	0.8
Tinnitus: Yes, now most or all of the time	1.0	1.2	3.4	1.8	1.1	1.4	0.9	0.7	0.3	0.4
Heart disease (siblings)	1.0	1.2	3.9	-0.3	0.4	0.5	0.4	1.8	0.9	2.0
Body Mass Index (BMI) (2010)	0.9	1.3	2.9	-1.2	-0.9	-0.0	-0.9	1.6	0.1	1.7
Blood Eosinophil Count	0.9	6.9	16.5	-0.4	-1.6	-2.6	-2.3	3.0	2.9	4.1
Hearing difficulty/problems: Yes	0.9	1.3	3.8	0.7	-0.1	0.0	0.3	1.8	1.2	1.9
Supplements: Zinc	0.9	1.0	2.4	-0.4	-1.3	0.7	-1.6	1.0	0.6	0.9
Medication: Co-codamol	0.9	1.0	2.2	1.2	0.1	0.8	1.0	1.5	-1.0	0.8
Diabetes (father)	0.9	1.1	2.4	-1.5	-0.7	0.1	0.9	-0.7	-1.4	-1.2
High blood pressure (mother)	0.9	1.3	4.0	-2.0	-0.8	-1.1	-1.7	0.0	0.2	0.6
Hair/balding pattern: Pattern 3	0.9	1.3	2.9	-1.2	0.2	-1.0	0.3	-1.6	-1.1	-1.7
Illnesses of mother	0.9	1.1	3.8	1.4	-0.5	0.3	1.9	0.2	0.1	-1.2
Eye problems/disorders: None of the above	0.9	1.0	3.3	-1.8	-0.8	-1.0	-1.0	0.2	1.0	0.3
Mean time to correctly identify matches	0.9	1.7	3.8	2.0	1.1	0.8	1.4	1.4	1.2	0.8
Chest pain or discomfort	0.9	1.3	2.9	0.9	0.7	1.7	1.0	0.9	1.1	1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.9	1.9	7.6	0.7	-0.3	2.7	0.7	2.1	0.2	0.8
Financial situation satisfaction	0.9	1.1	4.9	0.3	-2.2	0.8	0.1	0.6	-1.3	0.5
Supplements: Fish oil (including cod liver oil)	0.9	1.2	3.7	1.2	0.2	1.1	0.1	1.9	0.9	1.0
Ulcerative Colitis (UC)	0.8	1.6	3.3	-0.1	-1.8	-1.4	-1.0	-1.2	-1.1	-1.5
Age at First Birth	0.8	1.1	2.4	1.0	0.1	0.8	0.1	-1.2	-1.5	-1.6
Bipolar Disorder (2011)	0.8	0.7	1.6	-0.9	-0.9	-0.9	-1.3	-0.3	0.9	-0.5
Medication for hormone replacement therapy	0.8	0.9	1.9	-0.3	-1.3	0.5	-0.9	-1.4	-0.8	-0.9
Had other major operations	0.8	1.0	2.5	-1.4	-1.3	-1.6	-0.9	0.0	0.0	-0.2
Heart attack	0.8	1.0	3.9	-0.9	-0.2	1.2	0.3	2.0	1.0	-0.2
Illnesses of siblings	0.8	1.1	2.2	-1.5	-0.1	-0.8	-0.8	-1.4	-0.9	-1.4
Noisy workplace	0.8	1.0	2.6	1.2	0.3	1.2	0.0	-1.1	0.1	-1.6
Serious illness, injury or assault of a close relative in last 2 years	0.8	0.9	2.8	0.4	-0.5	0.5	-0.7	-0.8	-1.3	-1.7
Qualifications: O levels/GCSEs or equivalent	0.8	1.3	3.3	-1.8	0.6	-0.1	-1.6	-1.3	-0.3	-0.8
Hypothyroidism/myxoedema (self-reported)	0.8	1.6	5.0	0.2	0.3	0.8	-0.0	1.7	1.8	2.2
Forced vital capacity (FVC), Best measure	0.8	3.1	6.5	-2.6	-1.6	1.6	-2.2	2.1	-0.8	0.1
Neck or shoulder pain in last month	0.8	1.1	2.8	-0.3	1.7	-1.6	0.3	-1.2	-0.4	-0.4
Migraine (self-reported)	0.8	0.9	3.5	-0.3	1.9	-0.6	-0.0	0.9	0.2	1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.0	-0.1	1.1	-1.1	-0.0	0.2	1.7	1.0
Loneliness, isolation	0.8	1.1	2.4	-1.4	-1.2	0.1	0.1	1.6	0.9	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	3.9	0.2	0.7	0.1	2.0	1.4	0.1	0.2
Medication: Atorvastatin	0.8	1.0	2.5	0.2	-0.6	0.5	1.6	1.4	0.9	0.9
Number of operations (self-reported)	0.8	1.1	4.3	-1.7	-0.4	-2.1	0.3	0.2	0.3	0.5
Fractured/broken bones in last 5 years	0.8	1.1	3.9	0.5	0.5	-0.2	0.8	-1.2	-1.0	-2.0
Alzheimer’s Disease (in mother)	0.7	0.8	2.4	-0.0	1.6	0.1	0.7	-1.2	-1.0	-0.7
Major Depression (MDD)	0.7	0.8	1.9	1.3	1.1	0.8	1.4	0.2	0.4	-0.2
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.1	0.7	-1.8	0.8	-0.1	0.8	-1.2	-0.6
Diabetes (mother)	0.7	0.9	2.5	-0.5	0.4	-0.8	0.8	0.7	1.6	1.2
Severe depression (siblings)	0.7	0.8	2.8	0.5	-1.4	1.7	-0.2	0.4	-0.0	-0.5
Hand grip strength (right)	0.7	1.8	7.9	0.0	-1.0	2.8	-0.7	1.2	0.8	1.1
Taking other prescription medications	0.7	1.1	2.7	1.0	0.9	1.2	0.7	1.6	0.6	1.1
Supplements: Glucosamine	0.7	0.9	3.4	-0.6	-0.2	-0.0	1.3	1.9	0.2	0.6
Medication: Levothyroxine sodium	0.7	1.1	2.8	-0.0	1.2	0.5	-0.3	0.8	1.7	1.6
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.8	-0.8	0.0	-1.9	0.7	0.1	1.2	0.0
Medication: Simvastatin	0.7	1.0	2.9	-1.7	0.2	0.3	-1.2	1.1	1.1	0.5
Frequency of tiredness / lethargy in last 2 weeks	0.7	1.1	6.0	-0.8	0.0	-0.0	-2.5	-0.3	-0.9	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.2	4.9	-2.2	-1.9	1.2	-1.4	1.6	-0.8	-0.3
Standing height	0.7	6.7	24.2	-4.0	-0.9	-0.5	-4.9	1.5	-1.8	0.5
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.2	1.5	-1.5	0.9	0.9	-0.2	-0.3	-0.2
Medication: Allopurinol	0.7	1.0	3.7	0.3	0.5	-0.6	0.8	-1.9	-0.5	-1.2
Medication: Omeprazole	0.7	0.8	2.7	-1.6	0.3	-1.1	-1.0	0.4	-0.3	0.3
Comparative height size at age 10	0.7	3.8	11.1	-0.8	0.9	1.2	-1.3	3.3	0.8	3.3
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	4.0	-0.8	2.0	-0.8	1.0	0.0	0.1	-0.1
Ever taken oral contraceptive pill	0.7	0.8	1.4	-0.1	-1.1	1.1	-0.6	1.2	0.7	0.9
Commuting to job workplace: Public transport	0.7	0.8	2.0	0.9	1.3	1.4	0.6	-0.3	0.6	0.0
Risk taking	0.7	1.0	3.5	-0.7	0.7	-0.5	-1.9	-0.3	-1.0	-1.1
Age started oral contraceptive pill	0.7	0.9	2.5	-1.0	-0.3	-0.9	0.1	1.6	1.1	1.0
Diastolic blood pressure, automated reading	0.7	2.3	6.9	-0.7	2.6	-1.6	-0.4	1.1	1.4	1.5
HDL Cholesterol	0.6	1.1	3.5	0.3	1.9	-0.6	0.2	-1.1	-0.9	-1.2
Type 2 Diabetes (T2D) (2018)	0.6	1.1	2.6	-0.6	-0.3	1.5	0.8	0.6	1.2	1.6
Lung FEV1/FVC ratio	0.6	3.1	10.2	3.2	-1.1	2.7	1.7	0.7	0.2	0.1
Hand grip strength (left)	0.6	1.5	7.7	0.5	-1.2	2.8	0.2	0.9	-0.0	0.4
Average weekly spirits intake	0.6	0.8	2.2	0.0	1.5	0.2	1.4	0.6	-0.8	-0.2
Average weekly fortified wine intake	0.6	0.7	2.1	-1.4	0.3	-0.4	-1.0	-0.2	-1.1	-0.7
Bilateral oophorectomy (both ovaries removed)	0.6	0.6	2.1	-0.4	0.3	0.7	-0.1	-1.5	-0.5	-1.1
Qualifications: CSEs or equivalent	0.6	0.8	3.1	-1.8	-1.3	-0.7	-0.2	0.1	0.6	0.0
Serious illness, injury or assault to yourself	0.6	0.8	2.1	-0.8	-1.4	-1.0	-1.0	-0.1	-0.6	-0.6
Past tobacco smoking	0.6	1.0	3.6	0.0	0.3	-0.7	-0.3	-0.8	-1.9	-1.6
Forced vital capacity (FVC)	0.6	2.4	5.4	-1.6	-2.2	1.6	-0.8	2.3	-0.9	-0.0
Heel bone mineral density (BMD) T-score, automated (right)	0.6	1.3	3.0	0.6	1.2	1.1	-1.3	1.7	0.5	1.1
Pain all over the body in last month	0.6	0.7	1.5	0.6	0.6	1.1	-1.2	-0.7	-0.1	-0.9
Diabetes (self-reported)	0.6	0.9	3.0	0.3	0.9	1.2	0.7	0.7	0.5	1.7
Fluid intelligence score	0.6	1.3	4.1	1.8	-0.9	2.0	0.7	0.2	-0.2	-0.3
Time employed in main current job	0.6	0.7	1.8	0.4	1.4	-0.1	1.0	-0.2	-0.7	-1.1
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	5.1	-1.1	-2.2	2.1	-0.6	1.9	-0.6	-0.1
Pulse wave Arterial Stiffness index	0.6	0.8	3.7	0.6	0.5	0.4	1.9	-0.2	-0.5	-0.6
Breastfed as a baby	0.6	0.8	2.2	-0.8	-0.0	0.9	-0.6	1.5	0.9	0.7
Peak expiratory flow (PEF)	0.6	1.3	4.5	-0.2	-1.5	2.1	0.1	1.3	0.7	0.5
Headache pain in last month	0.6	1.1	3.7	-1.8	0.1	-1.9	-0.6	0.2	-0.4	0.4
Arm fat-free mass (right)	0.6	3.2	12.0	-2.6	-0.3	-0.6	-3.5	1.6	-0.5	0.4
Arm predicted mass (right)	0.6	3.0	11.6	-2.5	-0.5	-0.6	-3.4	1.5	-0.5	0.3
Pulse rate, automated reading	0.6	1.8	3.7	0.1	1.8	0.3	-1.1	-1.9	-1.5	-1.5
Suffer from ‘nerves’	0.6	0.9	3.0	0.9	-0.5	-0.0	1.0	0.6	1.7	0.9
Leg pain on walking	0.6	0.7	3.5	1.9	0.1	0.5	1.0	0.3	-0.1	0.1
Illnesses of siblings: Diabetes	0.6	0.7	1.8	-0.0	-0.8	-0.2	-0.4	1.3	1.2	1.0
Commuting to job workplace: Walk	0.6	0.7	1.9	-0.3	-0.1	0.3	-0.1	1.3	1.4	1.0
Eye problems/disorders: Cataract	0.6	0.7	3.0	1.1	-0.4	0.2	1.7	0.4	-0.4	0.2
Hearing aid user	0.6	0.7	3.0	-0.5	-0.3	-0.5	1.0	-0.6	-1.7	0.2
Average weekly beer plus cider intake	0.6	0.9	3.6	0.3	0.7	0.3	0.3	0.9	0.9	1.9
Unable to work because of sickness or disability	0.6	0.7	1.5	1.2	0.0	1.2	0.7	0.7	-0.4	1.0
Commuting to job workplace: Cycle	0.6	0.7	2.7	-0.2	-0.1	0.0	1.6	1.2	-0.6	0.6
Supplements: Calcium	0.6	0.6	1.7	0.9	-0.2	1.0	-0.1	1.3	0.8	0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.8	2.8	-0.8	-0.3	1.0	0.4	1.7	0.6	-0.5
Schizophrenia vs Biploar Disorder	0.5	0.6	1.5	0.9	0.9	0.4	1.2	-0.3	-0.7	-0.8
Irritable Bowel Disease (IBD)	0.5	1.2	3.5	1.9	-1.2	-0.2	0.6	-1.2	-1.1	-0.7
Allergy or Eczema	0.5	1.2	2.6	1.0	-0.6	1.3	0.7	-0.7	-1.6	-1.4
Lung FVC	0.5	2.5	9.5	-0.5	-0.9	1.9	1.4	3.1	1.0	0.4
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.5	1.2	-0.0	-0.4	1.6	-0.6	-0.4	0.0
Relative age of first facial hair	0.5	1.0	3.4	0.3	-1.8	0.2	0.4	-0.8	-0.6	-1.6
Pack years adult smoking proportion	0.5	0.7	1.7	-0.8	-0.3	-0.5	-1.2	-0.3	0.9	1.3
Leg fat-free mass (left)	0.5	2.7	9.1	-2.5	-0.9	0.4	-3.0	0.2	-1.4	-0.8
Townsend deprivation index at recruitment	0.5	0.7	2.3	0.8	-0.7	0.8	-0.6	0.6	0.4	1.5
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.2	3.6	0.7	0.8	1.2	-1.0	1.9	1.0	0.7
Tinnitus: Yes, but not now, but have in the past	0.5	0.6	1.3	0.8	0.5	0.3	-0.2	-1.1	-1.0	-0.7
Hayfever, allergic rhinitis or eczema	0.5	1.1	1.8	1.1	-0.9	1.1	1.2	-0.4	-1.1	-1.3
Sitting height	0.5	3.8	12.0	-2.4	-0.9	0.8	-3.5	1.7	-2.1	-0.3
Leg predicted mass (left)	0.5	2.8	9.2	-2.6	-0.9	0.4	-3.0	0.2	-1.4	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.5	0.7	1.6	0.8	-0.3	0.3	1.2	-1.3	-0.6	-1.0
Medication: Paracetamol	0.5	0.9	2.3	-1.5	-0.1	-1.1	-1.0	1.1	0.0	0.4
High blood pressure (siblings)	0.5	0.8	1.5	0.6	1.1	0.3	0.7	0.8	1.2	1.1
Health satisfaction	0.5	0.6	2.1	0.7	0.2	-0.4	1.4	-0.6	-1.1	0.0
Shortness of breath walking on level ground	0.5	0.6	1.2	-0.0	1.1	-0.3	0.7	0.8	-1.0	-0.9
Had major operations	0.5	0.6	2.1	-0.5	0.9	-0.7	0.5	0.2	0.6	1.5
Family relationship satisfaction	0.5	0.7	1.5	1.1	-0.8	0.9	1.2	-0.4	-0.3	0.1
Whole body fat-free mass	0.5	2.7	10.6	-2.3	-1.0	0.1	-3.2	0.8	-1.2	-0.3
Leg fat-free mass (right)	0.5	2.8	9.7	-2.4	-1.0	0.7	-3.1	0.1	-1.5	-0.8
Osteoarthritis (self-reported)	0.5	0.7	1.4	-0.6	-1.1	-0.6	0.6	1.1	-1.2	0.1
Whole body water mass	0.5	2.9	11.3	-2.4	-1.2	0.0	-3.4	0.8	-1.2	-0.5
Leg predicted mass (right)	0.5	2.8	9.4	-2.4	-1.0	0.7	-3.1	0.0	-1.6	-0.8
Guilty feelings	0.5	0.8	2.4	-1.0	-0.6	-1.5	-0.3	0.4	0.4	1.1
Mother’s age at death	0.5	0.6	2.6	-1.0	0.2	-1.6	0.6	-0.2	-0.4	0.1
Medication: Blood pressure	0.5	0.9	2.3	0.2	0.8	0.7	0.2	1.5	1.4	0.7
Ever smoked	0.5	0.8	2.5	-0.5	-0.6	-0.1	-0.0	0.5	1.6	1.5
Basal metabolic rate	0.5	2.6	10.0	-2.3	-0.8	0.1	-3.2	1.0	-1.0	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.5	0.6	2.4	-1.6	0.1	-0.9	-0.6	0.6	-0.0	0.0
Pack years of smoking	0.5	0.7	1.7	-0.9	0.2	-0.3	-1.3	-0.1	0.9	1.3
Arm predicted mass (left)	0.5	2.5	9.1	-2.3	-0.7	-0.8	-3.0	1.4	-0.6	0.2
Intelligence (Savage-Jansen 2018)	0.4	1.3	5.4	1.1	-0.5	2.3	-0.8	0.8	-0.8	-0.4
Worry (Nagel 2018)	0.4	0.9	2.1	-0.6	-0.2	-1.5	0.1	0.5	1.4	1.0
Reaction Time	0.4	0.8	2.5	1.6	0.2	1.2	1.1	-0.1	0.1	-0.5
Lupus	0.4	0.7	1.8	0.2	0.4	-0.4	-0.6	-1.0	-1.1	-1.3
Rheumatoid Arthritis	0.4	0.5	1.2	-0.5	1.0	-0.8	1.1	-0.6	0.5	-0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.5	1.4	0.3	0.1	0.3	0.4	0.1	1.2	1.2
Heel T-Score	0.4	3.5	10.4	-1.1	1.3	0.4	-2.7	3.2	1.9	0.6
Height	0.4	8.2	23.5	-3.3	-1.4	0.3	-4.8	0.9	-4.5	0.1
Neuroticism	0.4	1.1	2.6	-1.1	-1.6	-0.6	-0.7	-0.0	1.0	1.3
Relative age voice broke	0.4	0.6	2.5	0.3	-1.0	-0.5	-0.1	-0.2	-0.7	-1.6
Number of incorrect matches in round	0.4	0.7	2.1	1.2	-0.6	-0.3	1.4	-0.5	-0.6	-0.7
Hearing difficulty/problems with background noise	0.4	0.6	1.5	1.1	-0.4	0.4	0.0	1.2	0.6	0.9
Financial difficulties in last 2 years	0.4	0.6	1.6	0.6	-0.4	1.3	-0.9	-0.1	0.8	0.3
Weight	0.4	1.8	5.0	-2.2	-0.1	-0.1	-2.2	1.5	-0.2	0.5
Trunk fat-free mass	0.4	2.5	10.6	-1.9	-1.1	0.0	-3.2	1.1	-1.1	-0.1
Happiness	0.4	0.5	1.1	-1.0	1.1	0.8	-0.1	0.5	-0.1	0.7
Medication: Cholesterol lowering	0.4	0.6	1.5	-1.1	-0.3	0.5	-0.6	1.2	0.9	0.4
Trunk predicted mass	0.4	2.5	10.2	-1.9	-1.1	-0.1	-3.2	1.1	-1.1	-0.2
Blood clot in the leg (DVT)	0.4	0.5	1.3	-0.7	0.7	-0.7	-1.1	0.6	0.5	-0.1
Wheeze or whistling in the chest in last year	0.4	0.6	1.8	0.6	-0.5	-0.6	-0.3	1.2	0.3	1.3
Age at first live birth	0.4	0.6	1.8	-1.1	1.3	0.5	-0.9	0.2	-0.1	-0.6
Mouth/teeth dental problems: Loose teeth	0.4	0.4	1.9	1.4	0.2	0.6	0.7	-0.2	0.1	0.1
Medication for pain relief, constipation, heartburn	0.4	0.8	3.0	1.7	-0.2	0.0	1.0	-1.0	-0.5	-0.0
Overall health rating	0.4	0.8	3.9	-0.2	-0.5	-0.2	-0.3	1.1	-0.2	2.0
Qualifications: NVQ or HND or HNC or equivalent	0.4	0.5	1.3	-0.7	-0.4	0.8	-0.8	0.7	-0.2	1.2
Breast cancer (self-reported)	0.4	0.5	2.3	-0.5	-0.0	0.5	0.1	-1.0	0.1	-1.5
Medication: Paracetamol	0.4	0.7	2.3	-0.8	-0.2	-0.8	-0.4	1.5	0.3	0.9
Arm fat-free mass (left)	0.4	2.1	8.0	-1.9	-0.6	-0.3	-2.8	1.5	-0.7	0.2
Deep venous thrombosis (DVT) (self-reported)	0.4	0.5	1.1	-0.6	0.8	-0.9	-1.1	0.5	0.4	-0.2
Bipolar Disorder (2018)	0.3	0.5	1.1	-0.5	-0.1	-0.5	-1.0	0.6	0.9	0.8
Ovarian Cancer	0.3	0.4	1.2	0.6	0.1	-0.2	0.6	1.1	-0.6	0.8
Fasting Glucose	0.3	0.4	1.0	-0.0	-0.6	-0.5	-0.2	-1.0	-0.4	-0.8
Cardiovascular Disease	0.3	1.0	4.1	-0.3	-0.1	-0.4	0.3	1.3	2.0	1.1
Sensitivity / hurt feelings	0.3	0.5	1.4	-1.2	-0.6	-0.7	-1.0	-0.0	0.1	0.2
Ever had hysterectomy (womb removed)	0.3	0.4	1.1	-0.5	1.0	-0.8	-0.1	-0.7	-0.0	0.3
Eye problems/disorders: Diabetes related eye disease	0.3	0.4	1.2	-0.4	0.6	-0.4	0.2	-0.8	-1.1	0.1
Impedance of leg (left)	0.3	1.3	2.6	-0.1	1.2	-1.3	1.3	0.7	1.1	1.6
Trunk fat mass	0.3	1.3	4.1	-2.0	0.8	-0.5	-1.2	1.4	0.2	0.7
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	1.1	-0.1	1.1	0.6	0.0	0.7	0.6	-0.1
Qualifications: None of the above	0.3	0.7	1.5	0.7	0.5	-0.7	0.2	1.0	1.1	1.2
Neuroticism score	0.3	0.5	1.3	-0.9	-1.1	-0.8	-0.4	0.1	0.6	0.7
Pulse rate	0.3	0.6	1.7	-1.3	0.7	0.7	-0.9	0.1	-0.1	-0.5
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.7	-0.4	0.7	1.2	-1.6	0.2	0.3	0.2
Asthma	0.3	0.5	1.9	1.4	0.5	0.5	-0.2	-0.1	0.4	1.0
Depression (self-reported)	0.3	0.3	0.7	-0.6	-0.3	-0.4	0.3	-0.9	-0.4	-0.9
Length of working week for main job	0.3	0.3	0.7	-0.7	0.4	-0.3	-0.8	-0.6	0.1	-0.5
Tense / ‘highly strung’	0.3	0.6	3.4	-0.1	1.8	-0.5	0.2	0.1	0.3	0.4
Ever highly irritable/argumentative for 2 days	0.3	0.4	0.8	-0.1	0.1	-0.5	-0.8	0.7	0.5	0.9
Leg fat percentage (right)	0.3	1.2	2.5	-0.8	1.6	-0.6	0.7	1.3	1.1	1.2
Medication: Seretide 50 evohaler	0.3	0.3	0.8	0.4	0.3	-0.8	0.6	-0.9	-0.3	-0.3
Commuting to job workplace: Car/motor vehicle	0.3	0.4	1.1	-1.0	-0.4	-0.2	-0.7	-0.3	-0.5	-0.7
Illnesses of father: Heart disease	0.3	0.4	0.7	-0.9	0.1	0.7	-0.8	0.7	0.0	0.8
Mood swings	0.3	0.5	1.2	0.8	-0.8	1.1	0.8	-0.2	-0.2	-0.0
Friendships satisfaction	0.3	0.4	1.3	-0.6	-0.5	-0.2	-0.2	-0.8	-1.2	-0.4
Back pain experienced in last month	0.3	0.5	1.5	0.3	-0.5	1.0	-0.3	1.2	-0.6	0.3
Asthma (self-reported)	0.3	0.7	2.6	1.6	0.5	0.7	0.0	0.0	0.4	1.1
Miserableness	0.3	0.6	1.0	-0.9	-0.9	-1.0	-0.5	-0.0	-0.8	0.7
Eye problems/disorders: Glaucoma	0.3	0.4	0.8	0.4	0.3	0.9	-0.9	0.2	-0.8	-0.3
Leg fat percentage (left)	0.3	1.2	1.9	-0.5	1.4	-0.5	0.8	1.4	1.3	1.2
Ever depressed for a whole week	0.3	0.4	0.8	0.0	0.1	0.7	0.9	0.9	0.1	0.8
Myopia	0.3	0.4	1.1	-0.9	0.2	-0.5	-1.0	-0.5	0.5	0.1
Bipolar Disorder or Schizophrenia	0.2	0.5	1.4	-0.3	0.1	0.3	-0.4	1.2	0.8	0.9
Depression (Nagel 2018)	0.2	0.3	1.4	0.7	-0.2	0.1	1.2	-0.6	-0.3	-0.2
Schizophrenia (2018)	0.2	0.3	1.1	0.0	0.2	0.9	0.3	1.0	0.3	0.5
Verbal and Numeric Reasoning (VNR)	0.2	0.6	2.7	-0.1	-1.7	0.7	-0.4	0.5	-0.7	-0.3
Breast Cancer	0.2	0.4	0.9	-0.4	0.2	-0.6	0.5	-0.6	-0.9	-0.9
Blood Platelet Count	0.2	2.3	6.4	0.1	2.5	-0.6	2.5	-1.8	0.3	-0.5
Chronotype (morning person)	0.2	0.5	1.7	0.6	1.0	0.6	-0.1	-1.3	0.3	0.0
Impedance of leg (right)	0.2	1.1	1.9	-0.3	1.4	-1.3	0.9	0.6	0.8	1.4
Trunk fat percentage	0.2	0.9	2.3	-1.5	1.3	-0.3	-0.4	1.1	0.5	0.9
Fed-up feelings	0.2	0.3	0.6	-0.7	0.0	-0.5	-0.4	-0.7	0.1	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.2	0.3	0.7	0.3	-0.9	0.6	0.6	-0.6	-0.3	0.1
Chronic bronchitis/emphysema (father)	0.2	0.2	0.7	0.3	0.1	-0.9	0.8	-0.1	0.0	-0.1
Waist circumference	0.2	0.7	1.6	-1.2	0.1	-0.8	-1.1	-0.3	-0.6	-1.0
Allergy	0.2	0.5	1.0	-1.0	-0.1	-0.8	-0.4	0.5	0.8	0.8
Mouth/teeth dental problems: Dentures	0.2	0.3	1.6	0.0	-0.1	0.0	1.3	0.3	-0.6	0.3
Prospective memory result	0.2	0.3	0.9	0.2	-0.9	-0.6	0.6	0.2	0.3	0.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.0	-0.6	-0.3	-1.0	0.0	0.1	-0.4	0.4
Hair/balding pattern: Pattern 4	0.2	0.4	1.6	0.4	-1.3	-0.6	0.3	-0.0	0.6	-0.3
Pulse wave reflection index	0.2	0.2	0.6	0.3	0.8	0.1	0.5	-0.4	-0.7	-0.2
Loud music exposure frequency	0.2	0.2	0.4	0.3	-0.3	0.5	0.2	0.6	-0.6	0.0
Mouth/teeth dental problems: Bleeding gums	0.2	0.3	0.8	0.4	-0.6	0.2	0.9	-0.1	0.3	0.6
Glaucoma (self-reported)	0.2	0.2	0.4	0.2	0.5	0.3	-0.6	0.6	0.2	0.2
Body fat percentage	0.2	0.8	1.5	-1.2	1.2	-0.3	0.1	1.1	0.8	0.8
Whole body fat mass	0.2	0.9	2.4	-1.6	0.5	-0.3	-0.7	1.5	0.6	0.9
Leg fat mass (right)	0.2	0.9	2.6	-1.6	0.6	-0.6	-0.3	1.3	0.4	0.8
Alcohol intake frequency.	0.2	0.4	1.4	-1.1	0.4	-1.2	0.2	-0.3	-0.5	-0.2
Supplements: Vitamin C	0.2	0.3	0.4	0.6	-0.5	0.7	-0.2	0.5	-0.6	0.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.2	0.2	0.9	0.1	-0.3	-0.2	0.8	0.1	0.1	-1.0
Ever had bowel cancer screening	0.2	0.3	0.8	0.1	0.3	-0.3	-0.8	0.4	-0.3	-0.9
Medication: Gliclazide	0.2	0.3	0.5	-0.7	-0.6	0.1	0.6	0.4	0.6	0.1
Arm fat mass (left)	0.2	0.8	2.2	-1.5	0.1	-0.2	-1.0	1.3	0.5	0.5
Medication: Bendroflumethiazide	0.2	0.3	0.7	-0.0	0.8	0.4	-0.1	0.4	0.8	0.2
Illnesses of father: High blood pressure	0.2	0.2	0.6	0.3	0.6	0.8	0.3	0.1	-0.3	-0.1
Irritability	0.2	0.4	0.8	0.9	0.2	0.7	0.8	-0.4	-0.4	-0.5
Cholesterol lowering medication	0.2	0.3	0.9	-0.8	0.9	0.1	-0.4	0.4	0.2	0.2
Pain experienced in last month	0.2	0.3	0.5	0.7	0.5	0.4	0.2	0.7	0.7	0.4
Basal cell carcinoma (self-reported)	0.2	0.3	1.3	-1.1	-0.6	-0.2	0.0	-0.2	0.0	-0.4
Leg fat mass (left)	0.2	0.8	2.1	-1.5	0.5	-0.5	-0.2	1.4	0.6	0.8
Depressed Affect (Nagel 2018)	0.1	0.3	0.8	-0.2	-0.9	-0.1	0.7	-0.3	-0.2	0.5
Neuroticism (Nagel 2018)	0.1	0.3	0.9	-0.2	-0.5	-0.9	-0.0	0.1	0.7	0.8
LDL Cholesterol	0.1	0.2	0.5	-0.3	0.1	0.4	-0.4	0.2	0.7	-0.7
Schizophrenia (2014)	0.1	0.3	1.2	-0.3	-0.2	0.6	-0.0	1.1	0.3	0.4
Ulcerative Colitis	0.1	0.1	0.5	0.7	-0.2	-0.2	0.1	0.5	-0.3	0.1
Blood Red Count	0.1	1.0	3.1	0.1	1.3	-1.8	-0.5	-1.3	0.3	-0.3
Smoking Status	0.1	0.3	1.1	0.1	0.0	1.0	0.1	-0.1	0.2	0.9
Respiratory disease	0.1	0.3	0.8	0.3	0.9	-0.1	-0.1	-0.3	0.6	0.7
Tanning	0.1	1.0	3.2	-0.9	-1.8	-0.2	-0.6	-0.2	-1.2	-0.9
Body mass index (BMI)	0.1	0.3	1.0	-0.5	0.2	0.1	-0.0	1.0	0.6	0.4
Had menopause	0.1	0.2	0.5	0.2	-0.7	-0.4	0.4	-0.0	-0.5	-0.4
Impedance of arm (right)	0.1	0.3	1.0	-0.0	0.5	0.4	0.8	-1.0	-0.3	-0.2
Arm fat percentage (right)	0.1	0.2	0.4	-0.4	0.6	0.3	0.6	0.5	0.6	0.1
Arm fat mass (right)	0.1	0.5	1.4	-1.2	-0.0	-0.0	-0.7	1.2	0.3	0.5
Worry too long after embarrassment	0.1	0.2	0.7	0.1	0.4	-0.8	-0.2	0.0	0.4	-0.1
Arm fat percentage (left)	0.1	0.3	0.8	-0.9	0.4	0.3	-0.1	0.7	0.8	0.1
Average weekly red wine intake	0.1	0.1	0.5	-0.3	-0.7	0.3	0.1	-0.1	0.0	-0.3
Qualifications: nursing, teaching	0.1	0.2	0.5	0.4	-0.3	0.1	0.7	-0.4	0.5	0.7
Medication for cholesterol	0.1	0.1	0.3	0.3	-0.4	-0.3	0.5	0.1	0.5	0.3
Illnesses of father: None of the above (group 1)	0.1	0.1	0.4	-0.0	0.2	-0.3	-0.4	-0.6	-0.2	-0.3
Average weekly champagne plus white wine intake	0.1	0.2	1.0	-0.4	-0.1	-0.1	-0.4	-0.0	0.3	-1.0
High cholesterol (Self-reported)	0.1	0.2	0.6	-0.7	0.6	0.1	0.1	-0.2	0.5	0.1
Impedance of whole body	0.1	0.5	1.7	-0.6	1.3	-0.7	0.5	0.0	0.4	0.9
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
BMI	0.0	0.3	1.1	-0.6	0.2	-0.1	1.0	0.0	-0.3	-0.4
Hair Pigment	0.0	1.4	3.1	1.7	1.8	1.4	1.1	-0.4	0.1	-0.4
Impedance of arm (left)	0.0	0.2	0.4	-0.6	0.5	0.4	-0.1	-0.6	-0.1	-0.0
Pain type(s) experienced in last month: Hip pain	0.0	0.1	0.2	-0.1	-0.1	-0.4	0.5	0.0	-0.0	-0.2

Hub : Genes

LPAR1

Models

Trait associations