TWAS hub - ZNF483

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	METSIM	Adipose	0.0354	0.0161	2.8e-03	0.026	0.002	0.012	0.011	0.017	7.3e-05	1.2e-01	5.6e-03	0.0079	9.9e-04
2	TCGA	Breast Invasive Carcinoma	0.0519	0.0299	2.2e-03	0.023	0.017	0.022	NA	0.019	1.2e-05	1.4e-04	2.3e-05	NA	6.3e-05
3	TCGA	Kidney Renal Clear Cell Carcinoma	0.0516	0.0262	2.6e-03	0.008	0.020	0.015	NA	0.005	3.4e-02	2.4e-03	7.1e-03	NA	8.1e-02
4	TCGA	Brain Lower Grade Glioma	0.0742	0.0332	1.1e-05	0.015	0.031	0.028	NA	0.024	7.7e-03	1.9e-04	3.3e-04	NA	7.9e-04
5	TCGA	Liver Hepatocellular Carcinoma	0.1090	0.0540	3.8e-03	0.004	0.031	0.021	NA	0.007	2.1e-01	1.3e-02	3.4e-02	NA	1.4e-01
6	TCGA	Prostate Adenocarcinoma	0.0589	0.0235	3.6e-05	0.077	0.049	0.064	NA	0.073	1.9e-08	6.4e-06	3.2e-07	NA	4.2e-08
7	TCGA	Thyroid Carcinoma	0.0380	0.0210	6.3e-03	0.040	0.014	0.021	NA	0.023	8.2e-05	1.4e-02	3.7e-03	NA	2.2e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Relative age of first facial hair	4.2	8.6	17.8	0.7	4.2	-0.9	2.9	3.0	3.2	3.5
Depression (self-reported)	4.1	4.9	11.5	1.1	1.8	2.1	-0.5	1.8	3.4	3.3
Age when periods started (menarche)	3.1	7.6	14.0	-0.5	3.7	-2.1	2.5	2.0	3.4	3.5
Alzheimer’s Disease (in mother)	3.0	3.5	6.9	1.4	1.4	1.7	0.6	1.9	2.6	2.6
Townsend deprivation index at recruitment	2.8	3.9	5.4	-1.8	-1.7	-2.3	-1.5	-2.2	-1.9	-2.3
Serious illness, injury or assault of a close relative in last 2 years	2.8	3.2	5.4	-1.7	-2.1	-1.5	-1.6	-2.3	-1.4	-1.6
Taking other prescription medications	2.5	3.9	7.2	1.9	1.6	1.3	1.4	2.3	2.2	2.7
Tense / ‘highly strung’	2.3	3.7	8.5	2.2	1.9	2.9	0.5	1.8	1.7	1.6
Illness, injury, bereavement, stress in last 2 years	2.3	2.8	6.1	2.5	-0.9	1.8	1.5	1.9	-1.5	-1.3
Financial situation satisfaction	2.3	2.9	7.3	-2.6	-0.1	-2.7	-0.9	-2.1	-0.6	-0.7
Falls in the last year	2.2	3.0	6.2	0.9	1.4	0.9	1.8	2.0	2.0	2.5
Medication: Ventolin 100micrograms inhaler	2.2	2.8	4.6	2.0	1.2	2.1	0.3	1.9	1.6	1.7
Gout (self-reported)	2.1	2.9	7.4	1.5	0.8	2.2	2.1	2.7	0.3	0.7
Medication: Amlodipine	2.1	2.9	6.6	1.0	-2.4	0.2	0.2	-0.9	-2.5	-2.6
Number of self-reported non-cancer illnesses	2.1	3.7	9.1	-1.0	1.3	-1.9	-1.2	-0.6	3.0	2.9
Relative age voice broke	2.0	3.0	7.0	0.3	2.0	-0.2	1.0	1.6	2.5	2.6
Chronic bronchitis/emphysema (father)	2.0	2.4	6.0	0.7	-1.2	-1.4	-0.5	-1.2	-2.2	-2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.0	2.3	5.2	1.4	1.3	1.0	0.8	1.1	2.1	2.3
Alzheimer’s Disease (including proxy)	1.9	2.7	5.2	1.4	0.8	1.6	1.0	2.3	1.9	2.0
Chronotype (morning person)	1.9	4.3	10.0	0.3	2.9	0.8	-0.3	1.7	3.2	2.9
Average weekly fortified wine intake	1.9	2.2	5.7	1.0	1.6	1.6	1.0	2.4	1.1	1.1
Financial difficulties in last 2 years	1.9	2.5	5.0	-2.1	0.9	-1.8	-2.2	-1.9	0.5	-0.0
Worry too long after embarrassment	1.9	3.2	7.7	2.8	1.1	1.6	2.5	2.2	-0.1	0.2
Number of full sisters	1.9	2.3	4.9	-1.5	-1.1	-2.0	0.2	-2.2	-1.5	-1.2
Fasting Glucose	1.8	2.1	7.5	-1.2	2.7	-0.5	-0.3	0.2	1.6	1.6
Ever had hysterectomy (womb removed)	1.8	2.0	4.9	2.2	1.6	1.1	0.8	1.3	1.2	1.3
Wears glasses or contact lenses	1.8	2.1	4.7	1.0	1.7	0.0	2.2	1.4	1.3	1.7
Medication: Lisinopril	1.8	2.3	11.1	1.4	0.5	0.8	3.3	1.1	0.2	1.1
Heel bone mineral density (BMD) T-score, automated (right)	1.7	4.0	9.9	1.8	1.7	0.5	3.2	1.9	1.6	2.3
Birth weight of first child	1.7	3.1	6.8	2.5	0.2	2.6	1.9	2.3	-0.0	0.3
Back pain experienced in last month	1.7	2.5	5.4	1.3	1.7	0.5	0.0	1.5	2.3	2.3
Medication: Aspirin	1.7	2.2	5.3	-0.1	-2.3	-1.3	-1.2	-1.8	-1.2	-1.5
Height	1.6	31.3	74.3	-0.8	8.6	-1.0	0.1	3.4	8.3	7.9
Illnesses of father: Heart disease	1.6	2.3	4.4	-1.1	-1.3	-1.2	-1.8	-2.1	-1.2	-1.5
Forced expiratory volume in 1-second (FEV1), predicted	1.6	3.3	7.9	-0.2	2.8	-1.1	0.3	0.4	2.6	2.6
High blood pressure (siblings)	1.5	2.2	5.1	1.2	-2.2	0.6	0.9	-0.1	-2.2	-1.8
Pulse wave peak to peak time	1.5	1.7	4.2	-0.2	1.8	-0.4	0.3	0.7	2.0	2.0
Bipolar Disorder (2011)	1.4	1.4	5.5	-1.3	0.5	-0.3	-2.3	-1.0	1.0	0.3
Rheumatoid Arthritis	1.4	1.9	3.0	1.2	-0.5	1.2	1.7	1.3	-1.7	-1.6
Blood White Count	1.4	10.0	28.6	-2.4	-3.9	-0.6	-1.7	-5.3	-3.1	-2.8
Stomach or abdominal pain in last month	1.4	1.7	4.8	0.8	1.2	-0.5	0.0	0.0	2.2	2.2
Happiness	1.4	1.7	5.3	0.4	0.3	0.4	1.3	0.8	2.0	2.3
Shortness of breath walking on level ground	1.4	1.7	5.5	2.3	-0.2	1.2	0.9	1.9	0.5	0.7
Medication: Blood pressure	1.4	2.5	5.8	1.0	-2.4	-0.4	-0.2	-1.6	-2.1	-1.9
Breast cancer (self-reported)	1.4	1.7	5.7	-0.2	0.3	0.5	-1.3	-0.0	2.4	2.0
Age at First Birth	1.3	1.8	5.5	1.5	0.3	1.0	2.4	1.7	0.5	1.0
Body Mass Index (BMI) (2010)	1.3	1.8	4.8	-0.2	-2.2	-0.5	-0.2	-2.0	-1.4	-1.3
Coronary Artery Disease (CAD)	1.3	1.5	2.6	-0.7	-1.6	-1.0	-1.0	-1.5	-1.3	-1.3
Qualifications: O levels/GCSEs or equivalent	1.3	2.0	3.5	1.3	1.6	1.3	0.1	1.3	1.7	1.9
Medication: Aspirin	1.3	1.8	5.9	-0.1	-2.4	-1.3	-0.6	-1.5	-0.9	-1.1
Illnesses of father: None of the above (group 1)	1.3	1.6	2.8	-0.1	1.6	1.7	1.1	1.5	1.0	1.1
Tinnitus: Yes, now most or all of the time	1.3	1.5	3.5	0.4	0.4	0.3	1.6	1.0	1.6	1.9
Ever smoked	1.3	2.3	5.0	-2.2	-0.5	-2.2	-0.9	-1.8	-0.8	-1.1
Risk taking	1.3	1.9	3.6	0.7	1.4	1.9	-0.2	1.8	1.5	1.3
Diastolic blood pressure, automated reading	1.3	4.0	8.5	2.9	-1.3	1.9	2.9	1.9	-1.4	-0.6
Crohns Disease (2017)	1.2	2.6	8.1	-0.2	-1.2	-0.7	0.4	-0.3	-2.9	-2.8
Allergy	1.2	2.8	5.7	-1.3	-1.7	-0.8	-1.2	-1.8	-2.0	-2.4
Father’s age at death	1.2	1.6	5.4	-0.6	0.5	0.6	-0.2	1.0	2.3	1.9
Standing height	1.2	11.5	33.1	-0.3	5.8	-0.5	0.5	2.7	4.5	4.4
Mouth/teeth dental problems: Bleeding gums	1.2	1.6	4.0	-1.7	-1.2	-1.5	-0.2	-2.0	-0.4	-0.4
Hypothyroidism/myxoedema (self-reported)	1.2	2.4	6.9	-1.2	0.6	-0.8	-2.6	-1.4	1.9	1.4
Handedness (chirality/laterality): Left-handed	1.2	1.4	3.2	-0.7	1.2	-1.2	-0.5	0.4	1.8	1.7
Osteoporosis (self-reported)	1.2	1.5	3.4	1.2	0.5	0.8	0.4	1.4	1.8	1.7
Crohns Disease (2012)	1.1	1.8	6.1	0.9	-0.8	0.1	0.8	0.1	-2.5	-2.0
Severe depression (siblings)	1.1	1.2	3.0	-1.1	-0.5	-0.6	-1.7	-1.0	1.4	0.9
Heart disease (mother)	1.1	1.3	3.0	-1.2	-1.4	-1.2	-1.1	-1.7	-0.3	-0.3
Age started oral contraceptive pill	1.1	1.4	6.0	0.6	1.3	-0.3	2.5	1.1	-0.2	0.7
Basal cell carcinoma (self-reported)	1.1	1.3	2.7	0.9	1.4	0.2	1.6	1.2	0.8	1.3
Schizophrenia vs Biploar Disorder	1.0	1.4	2.7	1.6	1.0	0.3	1.5	1.2	0.7	1.3
Bilateral oophorectomy (both ovaries removed)	1.0	1.2	2.6	0.9	0.5	0.3	1.6	1.3	1.1	1.3
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.4	0.0	-1.5	0.8	-0.5	-0.9	-1.6	-1.5
Sitting height	1.0	7.2	19.4	0.7	4.4	0.8	-0.2	2.7	3.5	3.2
Pulse wave Arterial Stiffness index	1.0	1.2	3.1	0.4	-1.4	0.4	0.1	-0.3	-1.8	-1.7
Medication for cholesterol, blood pressure or diabetes	1.0	1.6	4.2	-0.4	2.0	0.5	0.7	1.7	1.4	1.3
Hypertension (Self-reported)	1.0	2.8	5.0	-0.1	-2.1	-1.9	0.5	-1.4	-2.2	-1.9
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	1.8	-1.2	-0.2	0.3	-1.3	-1.3	-1.0	-1.1
Supplements: Calcium	1.0	1.1	3.5	0.5	0.8	0.2	-0.2	0.7	1.9	1.6
Schizophrenia (2018)	0.9	1.9	3.7	0.8	1.9	1.2	-0.1	0.8	1.8	1.9
Mean Putamen Volume	0.9	1.0	2.4	-0.8	1.2	-0.2	-0.6	-0.3	1.5	1.5
Type 2 Diabetes (T2D) (2012)	0.9	1.0	1.9	0.2	1.3	-0.4	1.2	0.9	1.1	1.4
Allergy or Eczema	0.9	2.3	5.2	0.5	1.4	1.3	0.5	1.4	2.2	2.3
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.3	-0.7	-0.6	-1.5	0.3	-1.0	-1.4	-1.3
Systolic blood pressure, automated reading	0.9	2.7	6.1	2.5	-1.0	1.6	2.4	1.8	-0.4	0.4
High blood pressure	0.9	2.4	4.9	0.2	-2.1	-1.6	0.9	-1.0	-2.2	-1.8
Had menopause	0.9	1.1	2.2	1.2	1.5	1.1	0.9	1.3	0.4	0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.9	0.3	1.5	-0.0	-0.0	0.6	1.7	1.7
Number of live births	0.9	1.2	2.2	-1.1	-0.9	-0.9	-1.1	-1.5	-1.0	-1.2
Medication: Cholesterol lowering	0.9	1.3	3.8	0.4	-1.9	-0.3	-1.0	-1.4	-0.9	-1.2
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.9	-1.7	-1.1	-1.5	-0.1	-0.6	-0.8	-0.5
Migraine (self-reported)	0.9	1.1	3.4	1.5	0.1	0.6	1.9	1.2	0.3	0.6
Medication: Allopurinol	0.9	1.2	2.2	0.9	-0.1	1.1	1.5	1.5	-1.1	-0.8
Pain experienced in last month	0.9	1.5	4.2	0.9	0.2	2.0	1.0	1.1	-1.5	-1.1
Blood Eosinophil Count	0.8	6.1	10.3	-2.3	-3.2	-1.2	-1.3	-2.4	-2.9	-3.0
Hypothyroidism (self reported)	0.8	1.7	4.4	-1.0	0.7	-0.6	-2.1	-0.9	1.8	1.3
Respiratory disease	0.8	1.7	3.6	0.9	1.1	1.3	0.8	1.3	1.5	1.9
Multivitamins +/- minerals	0.8	1.0	2.9	-0.6	1.0	-0.8	-0.5	0.2	1.7	1.5
Number of incorrect matches in round	0.8	1.3	3.2	-0.7	-0.9	-1.2	-1.8	-1.6	0.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.8	1.3	2.8	-1.0	1.2	0.0	-1.2	-0.6	1.7	1.3
Ever unenthusiastic/disinterested for a whole week	0.8	1.0	2.1	0.4	1.2	0.7	1.4	1.5	0.5	0.8
Medication: Ramipril	0.8	1.1	2.2	1.1	-1.5	-0.1	1.2	-0.4	-1.3	-0.8
Medication: Simvastatin	0.8	1.1	4.0	-0.1	-2.0	-0.8	0.3	-0.8	-1.2	-1.1
Time employed in main current job	0.8	0.9	2.1	1.3	0.4	1.4	1.1	0.4	-0.8	-0.4
Asthma	0.8	1.7	4.3	0.7	1.6	0.4	0.2	0.9	1.9	2.1
Loud music exposure frequency	0.8	0.9	1.3	0.9	1.1	1.1	0.3	0.9	1.0	1.1
Blood clot in the leg (DVT)	0.8	1.0	3.2	0.6	0.8	0.0	-0.3	-0.0	1.7	1.8
Age at first live birth	0.8	1.5	3.1	1.5	1.1	1.8	0.6	1.8	0.4	0.5
Medication for pain relief, constipation, heartburn	0.8	1.4	4.3	-0.4	-0.0	1.3	-0.2	-0.0	-2.1	-1.9
Mood swings	0.8	1.4	2.8	-1.7	-1.2	-1.1	0.5	-1.4	-1.2	-1.0
Commuting to job workplace: Cycle	0.8	1.0	1.7	0.4	1.3	1.2	1.3	1.2	0.1	0.7
Myopia	0.8	1.2	5.8	-0.8	0.2	-0.5	-2.4	-1.2	0.6	0.0
Deep venous thrombosis (DVT) (self-reported)	0.8	1.0	3.1	0.7	0.9	0.1	-0.3	0.1	1.6	1.7
Major Depression (MDD)	0.7	0.9	2.3	1.0	0.9	1.0	0.5	1.5	0.7	0.8
HDL Cholesterol	0.7	1.1	2.0	1.3	-1.4	0.4	-0.3	0.6	-1.2	-1.4
Lupus	0.7	1.0	2.3	0.7	1.5	0.2	0.3	1.5	1.0	0.9
BMI	0.7	3.9	12.0	0.9	-3.5	1.8	0.2	-1.2	-2.4	-2.0
Medication: Co-codamol	0.7	0.8	2.2	1.5	0.2	0.4	-0.2	0.8	1.2	1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.2	-1.4	0.1	-1.5	0.3	-0.8	0.9	1.0
Hayfever, allergic rhinitis or eczema	0.7	1.5	2.6	0.6	1.4	0.8	0.9	1.4	1.5	1.6
Mouth/teeth dental problems	0.7	1.1	3.1	0.4	-0.5	0.6	-1.5	0.1	-1.3	-1.7
Mouth/teeth dental problems: Dentures	0.7	1.3	6.0	0.6	0.1	0.9	2.4	0.6	0.2	1.1
Impedance of arm (left)	0.7	3.2	6.8	-0.9	2.6	-1.7	-0.2	0.1	2.6	2.4
Hair/balding pattern: Pattern 4	0.7	1.8	7.8	-2.8	-0.3	-1.2	-1.0	-1.0	0.9	0.7
Medication: Paracetamol	0.7	1.2	3.5	-0.5	0.1	-1.2	-0.4	-0.6	1.9	1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.1	1.0	-0.9	-0.1	0.5	-0.2	-1.4	-1.2
Chest pain or discomfort	0.7	1.0	1.7	-1.1	0.2	0.2	-1.2	-0.8	1.3	1.2
Knee pain experienced in last month	0.7	1.1	2.1	-0.4	-1.3	-1.2	-0.2	-0.5	-1.4	-1.5
Illnesses of siblings: Diabetes	0.7	0.8	1.5	-0.8	-1.0	-1.0	-0.9	-1.2	-0.5	-0.6
Long-standing illness, disability or infirmity	0.7	1.1	3.1	-0.0	1.4	0.7	0.7	0.5	1.2	1.8
Guilty feelings	0.7	1.1	5.7	0.0	-0.3	-0.5	2.4	0.0	-1.2	-0.6
Supplements: Fish oil (including cod liver oil)	0.7	0.9	1.8	-1.0	-0.1	-1.1	-0.4	-0.7	1.2	1.3
Medication: Atorvastatin	0.7	0.8	2.6	0.1	-0.6	-0.4	-1.6	-1.4	-0.5	-0.8
Ever had prostate specific antigen (PSA) test	0.7	0.8	2.0	-0.2	1.0	0.5	-0.8	0.8	1.4	1.0
Fractured/broken bones in last 5 years	0.7	0.9	2.8	0.9	0.8	1.7	-0.7	0.8	0.9	0.5
Vascular/heart problems diagnosed by doctor	0.7	1.8	3.6	-0.1	1.8	1.9	-0.7	1.3	1.5	1.2
Heart disease (siblings)	0.7	0.9	3.1	-0.5	-1.1	-0.9	-0.3	-1.8	-0.5	-0.3
Bipolar Disorder or Schizophrenia	0.6	1.5	3.5	0.5	1.6	1.0	-0.7	0.5	1.9	1.6
Irritable Bowel Disease (IBD)	0.6	1.5	3.6	-0.3	-1.2	-1.4	0.0	-0.6	-1.8	-1.9
Ovarian Cancer	0.6	0.8	1.9	1.2	-0.1	0.5	1.4	0.3	-1.2	-0.8
Schizophrenia (2014)	0.6	1.4	3.2	0.7	1.8	1.1	0.2	1.3	1.2	1.3
Cardiovascular Disease	0.6	2.1	4.3	-0.6	-1.9	-2.1	-0.8	-1.8	-1.0	-1.1
Sensitivity / hurt feelings	0.6	1.1	3.6	0.7	1.4	0.6	1.9	1.0	-0.4	0.1
Tinnitus: Yes, but not now, but have in the past	0.6	0.7	1.5	-0.2	-1.2	-0.3	-0.1	0.6	-1.1	-1.2
Serious illness, injury or assault to yourself	0.6	0.7	1.9	-0.8	0.1	-0.5	-0.1	-0.6	1.4	1.4
High blood pressure (mother)	0.6	0.8	2.3	0.2	-1.0	0.3	0.7	-0.8	-1.5	-1.1
Body mass index (BMI)	0.6	2.5	8.4	0.8	-2.9	1.3	0.2	-1.0	-1.9	-1.6
Impedance of leg (left)	0.6	2.9	7.9	0.1	2.2	-0.2	-1.3	0.3	2.8	2.4
Past tobacco smoking	0.6	1.2	1.9	1.3	0.1	1.4	0.0	1.0	1.3	1.4
Alcohol usually taken with meals	0.6	0.9	2.5	-0.8	-0.8	-0.4	-0.4	-0.3	-1.6	-1.5
Impedance of arm (right)	0.6	2.6	5.9	-0.8	2.1	-1.5	-0.3	-0.1	2.4	2.2
Medication: Ibuprofen (e.g. Nurofen)	0.6	0.7	2.1	-0.3	-0.0	-1.1	-0.3	-0.2	1.4	1.2
Headache pain in last month	0.6	1.0	2.2	-1.5	0.3	-0.3	-1.3	-0.9	1.1	0.7
Glaucoma (self-reported)	0.6	0.7	2.3	1.5	-1.3	0.1	0.2	0.0	-0.6	-0.6
Exposure to tobacco smoke outside home	0.6	0.8	2.1	-1.5	-0.6	-1.1	0.2	-0.8	0.6	0.8
Comparative body size at age 10	0.6	1.6	4.8	2.2	-0.4	1.7	0.9	1.5	-0.2	-0.1
Health satisfaction	0.6	0.7	2.3	0.5	0.6	0.3	0.3	0.5	1.4	1.5
Alcohol intake frequency.	0.6	1.5	4.1	2.0	0.2	1.6	1.3	0.7	0.6	1.0
Overall health rating	0.6	1.2	3.4	-0.8	0.4	-0.5	-1.8	-1.7	0.9	0.6
Family relationship satisfaction	0.6	0.8	3.0	-1.0	-0.2	-1.3	1.7	-0.1	-0.3	-0.0
Smoking status: Previous	0.6	0.9	1.9	-1.0	0.1	-1.0	0.4	-0.8	-1.4	-1.2
Average weekly red wine intake	0.6	0.8	1.2	-0.5	-0.7	-0.9	-0.9	-1.1	-1.0	-1.0
Asthma (self-reported)	0.6	1.3	3.2	0.8	1.4	0.3	0.2	0.8	1.6	1.8
Medication: Gliclazide	0.6	0.7	2.3	-1.5	-0.9	-0.8	0.3	-0.6	-0.8	-0.6
Hearing aid user	0.6	0.7	1.5	-0.2	-0.5	0.7	-1.2	-0.5	-0.9	-1.2
Ever depressed for a whole week	0.6	0.7	3.2	-0.1	-0.4	0.3	1.8	0.7	-0.8	-0.3
Alcohol drinker status: Previous	0.6	0.7	1.2	1.1	0.2	0.9	-0.4	-0.3	1.1	1.0
Impedance of whole body	0.6	2.8	6.9	-0.2	2.5	-0.8	-0.6	0.2	2.6	2.3
HbA1C	0.5	0.6	2.5	-0.3	-1.6	-0.6	-0.9	-0.5	0.0	-0.4
LDL Cholesterol	0.5	0.7	1.3	0.1	0.9	-1.2	-0.7	-0.5	1.1	1.0
Primary Biliary Cirrhosis	0.5	0.8	1.8	0.0	-1.3	-1.3	1.1	0.1	-0.6	-0.5
Lung FEV1/FVC ratio	0.5	2.7	6.9	-2.4	-1.0	-2.6	-0.5	-2.0	0.8	0.7
Number of treatments/medications taken	0.5	0.9	2.1	1.4	0.4	-0.1	0.6	0.7	1.1	1.3
Vitamin and mineral supplements	0.5	0.7	1.9	0.2	-0.9	0.6	0.0	-0.5	-1.4	-1.3
Medication: Metformin	0.5	0.7	2.2	-0.2	0.2	-0.4	1.5	-0.0	0.8	1.4
Pack years adult smoking proportion	0.5	0.7	2.6	-0.5	-1.0	-1.6	0.2	-0.6	-0.7	-0.7
Impedance of leg (right)	0.5	2.2	6.7	0.3	1.7	0.0	-0.8	0.4	2.6	2.3
Maternal smoking around birth	0.5	0.7	2.3	1.3	-0.4	0.1	0.5	1.5	0.6	0.4
Qualifications: CSEs or equivalent	0.5	0.7	1.1	-1.0	-1.0	-0.5	-0.3	-0.5	1.0	1.0
Fluid intelligence score	0.5	1.1	3.4	-0.4	0.5	1.3	-1.8	-0.4	1.2	0.6
Illnesses of siblings	0.5	0.7	2.6	-0.5	1.6	0.4	-0.2	0.8	0.9	0.6
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.8	2.2	-0.2	-0.9	-0.2	0.2	-0.7	1.3	1.5
Pulse rate	0.5	0.8	3.1	1.0	0.8	1.8	-0.9	0.4	0.3	-0.0
Illnesses of mother	0.5	0.6	1.5	-0.1	-0.1	-1.0	0.2	0.0	-1.2	-1.2
Exposure to tobacco smoke at home	0.5	0.5	1.5	0.2	0.8	0.4	0.0	0.4	1.2	1.1
Breastfed as a baby	0.5	0.6	1.0	0.8	0.9	0.6	-0.9	0.3	1.0	0.9
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.1	0.9	0.9	0.7	-0.0	1.0	0.8	0.7
Leg fat percentage (right)	0.5	1.6	5.3	1.4	-2.3	1.8	0.0	-0.6	-0.7	-0.4
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.5	-0.5	-0.8	0.0	-1.0	-0.1	-1.0	-1.2
Neck or shoulder pain in last month	0.5	0.7	1.4	-0.3	-0.5	-0.9	0.8	-0.5	1.1	1.2
Supplements: Vitamin C	0.5	0.6	1.4	0.5	1.2	-0.1	-1.1	0.4	0.9	0.7
Commuting to job workplace: Walk	0.5	0.6	1.3	-0.8	-0.3	-0.7	0.0	-0.8	-1.1	-0.9
Mouth/teeth dental problems: Mouth ulcers	0.5	0.9	2.4	1.2	1.5	-0.7	0.1	0.4	0.9	0.9
Miserableness	0.5	0.9	3.1	-1.7	-0.6	-0.2	0.2	-0.9	-1.2	-0.9
Pack years of smoking	0.5	0.7	1.9	-0.1	-1.1	-1.4	0.3	-0.3	-0.9	-0.8
Neuroticism (2016)	0.4	0.6	2.0	-0.6	-1.4	-0.4	0.3	-0.4	-0.8	-0.8
Blood Red Count	0.4	3.9	10.6	1.6	-1.7	0.8	3.3	2.0	-2.2	-1.2
Heel T-Score	0.4	3.1	7.7	2.5	-1.1	0.5	2.8	1.5	-1.6	-1.2
Systolic Blood Pressure	0.4	2.1	10.0	1.2	-0.6	0.9	3.2	1.2	-0.9	0.1
Type 2 Diabetes (T2D) (2018)	0.4	0.8	1.7	-1.1	-1.0	-1.0	0.6	-1.3	-0.2	0.0
Hand grip strength (left)	0.4	1.1	2.9	-1.6	-0.5	-1.0	-1.7	-0.8	-0.2	-0.9
Average weekly spirits intake	0.4	0.6	1.9	1.4	0.0	1.0	0.2	0.6	0.5	0.5
Eye problems/disorders: Diabetes related eye disease	0.4	0.5	2.3	1.5	0.1	0.6	0.6	0.4	0.2	0.3
Medication for hormone replacement therapy	0.4	0.4	1.3	0.3	0.1	-0.4	0.7	0.1	-1.1	-1.0
Diabetes (mother)	0.4	0.5	1.4	-0.2	0.2	1.0	0.1	0.2	1.2	1.1
Current tobacco smoking	0.4	0.6	1.8	-0.5	0.4	-0.2	-0.7	-0.3	1.3	1.1
Hair/balding pattern: Pattern 3	0.4	0.7	1.6	-0.4	-0.9	0.4	0.2	-0.6	-1.2	-1.3
Forced expiratory volume in 1-second (FEV1)	0.4	1.3	2.1	-1.5	1.3	-1.0	-1.2	-1.0	1.0	0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.7	3.3	0.7	0.2	1.8	0.5	0.6	0.1	0.4
Peak expiratory flow (PEF)	0.4	0.8	1.9	-1.4	0.3	-0.8	-1.2	-1.2	0.5	0.1
Forced vital capacity (FVC), Best measure	0.4	1.4	4.7	-0.5	2.2	0.1	-0.7	0.6	1.5	1.2
Number of children fathered	0.4	0.4	1.2	0.5	-1.1	0.2	-1.0	-0.7	0.2	-0.2
Qualifications: College or University degree	0.4	1.3	3.0	-0.2	1.7	0.8	-1.2	0.7	1.5	1.1
Emphysema/chronic bronchitis	0.4	0.5	1.5	0.5	-0.2	1.2	0.2	0.2	0.8	1.0
Ever had bowel cancer screening	0.4	0.5	1.2	0.2	0.7	0.1	-0.2	0.5	1.1	1.1
Diabetes diagnosed by doctor	0.4	0.7	1.2	-0.8	-0.1	-1.1	0.9	-0.4	0.7	1.1
Friendships satisfaction	0.4	0.5	2.0	0.1	0.6	0.3	1.4	0.7	0.4	0.8
Medication: Blood pressure	0.4	0.8	2.8	0.6	0.0	-1.2	1.7	0.4	-0.9	-0.4
Medication: Bendroflumethiazide	0.4	0.6	1.7	0.6	-0.5	-1.3	-0.5	-1.0	-0.5	-0.6
Illnesses of father: High blood pressure	0.4	0.5	1.0	-0.3	-0.8	1.0	-0.3	-0.5	-1.0	-0.7
Leg fat percentage (left)	0.4	1.3	3.6	1.4	-1.9	1.6	-0.3	-0.6	-0.6	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.4	0.5	0.9	-0.7	1.0	-0.6	-0.9	-0.5	-0.4	-0.4
Depressed Affect (Nagel 2018)	0.3	0.6	2.1	-1.5	-0.2	-1.0	0.7	-0.7	-0.1	0.1
Depression (Nagel 2018)	0.3	0.5	1.1	-0.8	0.3	0.2	-0.6	-0.5	1.0	1.0
Intelligence (Savage-Jansen 2018)	0.3	0.9	3.8	0.1	0.5	1.2	-2.0	-0.6	0.6	0.0
Worry (Nagel 2018)	0.3	0.7	1.2	0.9	1.0	0.4	0.7	1.1	0.8	0.7
Reaction Time	0.3	0.6	3.7	-0.3	0.5	-0.4	1.9	0.0	-0.4	0.0
Verbal and Numeric Reasoning (VNR)	0.3	0.7	2.1	0.3	0.2	1.4	-1.5	-0.0	0.8	0.2
Triglycerides	0.3	0.5	1.1	-0.5	0.4	-0.8	-0.4	-0.5	1.1	0.9
Neuroticism	0.3	0.6	1.8	-0.8	0.2	-1.3	1.3	-0.3	-0.5	-0.3
Frequency of depressed mood in last 2 weeks	0.3	0.4	0.9	-0.4	0.0	0.9	-0.5	-0.4	0.7	0.7
Angina	0.3	0.4	1.3	-0.7	-0.1	-0.8	-0.1	-1.1	0.4	0.5
Supplements: Zinc	0.3	0.3	1.5	-0.4	0.1	-1.2	0.0	-0.7	0.2	0.5
Diabetes (father)	0.3	0.4	1.0	-0.2	-0.3	1.0	0.5	-0.9	-0.7	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	2.7	1.6	0.3	0.4	0.7	0.4	0.8	0.9
Medication: Levothyroxine sodium	0.3	0.5	1.2	0.5	-0.2	0.1	-1.1	-0.5	0.9	0.7
Hearing difficulty/problems with background noise	0.3	0.5	2.7	0.2	-0.4	0.3	1.6	0.2	-0.6	-0.3
Hair/balding pattern: Pattern 2	0.3	0.4	1.1	-0.2	-0.2	-1.1	-0.8	-0.8	-0.4	-0.3
Forced vital capacity (FVC)	0.3	1.1	2.3	-1.2	1.5	-0.6	-1.1	-0.4	1.2	0.9
Qualifications: None of the above	0.3	0.7	4.1	0.2	-0.1	-0.6	2.0	0.1	-0.3	0.2
Pain all over the body in last month	0.3	0.3	1.7	0.3	-0.5	-1.3	0.4	-0.2	-0.0	-0.0
Diabetes (self-reported)	0.3	0.5	1.2	-0.8	-0.5	-1.1	0.8	-0.5	0.4	0.6
Neuroticism score	0.3	0.6	2.6	0.0	0.9	-0.0	1.6	0.7	0.2	0.5
Arm fat percentage (right)	0.3	1.2	5.1	0.3	-2.2	0.9	-0.0	-1.1	-0.9	-0.7
Alcohol intake versus 10 years previously	0.3	0.4	1.3	0.7	0.7	0.0	0.6	1.1	0.4	0.3
Noisy workplace	0.3	0.4	1.4	0.5	-1.2	-0.0	-0.9	-0.2	0.3	0.2
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.1	-0.0	1.4	1.1	0.2	0.6	0.7	0.9
Medication: Lansoprazole	0.3	0.4	0.7	0.4	0.5	0.8	0.8	0.8	-0.6	-0.3
Prospective memory result	0.3	0.4	2.0	-0.1	-0.8	-1.4	-0.3	-0.5	0.1	-0.0
Lung cancer (father)	0.3	0.4	1.1	0.7	0.1	0.2	-1.0	-0.3	0.9	0.5
Arm fat-free mass (right)	0.3	1.5	3.1	1.3	1.1	1.4	1.2	1.8	0.4	0.8
Number of full brothers	0.3	0.4	1.4	-0.4	0.3	1.2	-0.7	-0.2	-0.5	-0.5
Medication: Ibuprofen	0.3	0.4	1.1	-0.5	-0.1	-1.1	0.1	-0.3	0.8	0.7
Mean time to correctly identify matches	0.3	0.6	3.8	0.5	0.4	0.0	1.9	0.4	-0.3	0.2
Pulse rate, automated reading	0.3	1.0	2.9	0.9	-0.9	1.7	-1.4	0.8	0.5	0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.7	-0.5	-0.8	-0.3	-0.5	-0.6	0.5	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.4	1.4	-0.3	1.2	-0.9	-0.2	0.7	0.2	-0.1
Arm fat percentage (left)	0.3	1.0	4.2	0.3	-2.0	0.7	-0.1	-1.2	-0.8	-0.6
Qualifications: nursing, teaching	0.3	0.5	1.1	-1.0	-1.0	-0.4	-0.7	-0.2	-0.6	-0.8
Eye problems/disorders: Cataract	0.3	0.3	0.9	-1.0	0.1	-0.4	-0.9	-0.5	-0.3	-0.4
Medication for cholesterol	0.3	0.5	0.8	-0.9	-0.6	0.7	-0.8	-0.8	0.5	0.4
Mineral and other dietary supplements	0.3	0.4	1.3	0.6	1.1	0.6	0.2	0.8	-0.2	-0.5
Average weekly champagne plus white wine intake	0.3	0.4	1.1	-0.8	0.3	-0.1	-1.0	-0.4	0.8	0.4
Ever taken oral contraceptive pill	0.3	0.3	0.8	-0.9	0.2	-0.6	0.3	-0.7	0.2	0.5
Eye problems/disorders: Glaucoma	0.3	0.4	1.0	1.0	-1.0	0.2	-0.2	0.0	-0.5	-0.7
High cholesterol (Self-reported)	0.3	0.5	1.4	0.7	-1.1	-0.3	-1.2	-0.4	0.1	-0.3
Alcohol drinker status: Never	0.3	0.3	1.2	0.6	-0.5	1.1	0.4	-0.4	-0.3	-0.1
Number of operations (self-reported)	0.3	0.5	1.2	0.7	-0.5	1.1	0.8	0.4	0.2	0.7
Breast Cancer	0.2	0.4	1.9	-0.3	-0.0	0.3	1.4	-0.1	0.1	0.8
Ulcerative Colitis	0.2	0.3	0.7	0.5	0.6	-0.1	-0.4	0.2	0.8	0.7
Blood Platelet Count	0.2	1.9	4.7	0.6	-0.8	2.2	-0.0	0.4	-1.7	-2.0
Lung FVC	0.2	1.2	2.9	0.7	-1.2	0.9	0.3	-0.2	-1.7	-1.6
Other serious medical condition/disability diagnosed by doctor	0.2	0.2	0.5	0.1	-0.6	-0.6	-0.7	-0.2	0.4	0.2
Trunk fat percentage	0.2	0.6	1.7	1.0	-0.9	1.3	0.2	-0.3	0.5	0.7
Hand grip strength (right)	0.2	0.6	1.3	-1.1	-0.1	-1.0	-1.1	-0.8	0.3	-0.1
Trunk fat-free mass	0.2	1.2	3.0	0.2	1.7	0.6	0.7	1.5	0.9	1.1
Worrier / anxious feelings	0.2	0.3	1.3	-1.2	0.1	-0.5	0.1	-0.5	0.3	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	2.8	-0.6	1.7	-0.3	-0.7	-0.1	0.9	0.7
Trunk predicted mass	0.2	1.2	3.1	0.3	1.8	0.7	0.7	1.5	0.9	1.2
Length of working week for main job	0.2	0.3	0.7	0.5	-0.6	0.3	-0.1	-0.1	-0.8	-0.6
Pulse wave reflection index	0.2	0.3	1.2	0.2	-1.1	-0.7	0.1	-0.4	-0.4	-0.2
Ever highly irritable/argumentative for 2 days	0.2	0.3	1.3	0.4	-1.2	0.1	-0.3	-0.5	0.3	0.2
Birth weight	0.2	0.5	1.4	-0.1	-0.4	1.2	0.6	1.1	0.2	0.3
Body fat percentage	0.2	0.8	2.1	1.1	-1.4	1.3	0.1	-0.5	0.0	0.3
Angina (self-reported)	0.2	0.3	1.1	-0.3	-0.4	-0.6	0.0	-1.1	0.2	0.4
Medication: Omeprazole	0.2	0.2	0.4	-0.1	0.6	-0.7	0.2	-0.0	-0.6	-0.3
Leg fat mass (right)	0.2	0.9	2.4	1.1	-1.5	1.6	0.1	-0.3	-0.5	-0.2
Arm predicted mass (right)	0.2	1.1	2.5	1.1	1.1	1.3	0.9	1.6	0.2	0.5
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.3	1.2	-0.3	0.3	0.4	-1.1	-0.2	-0.1	-0.5
Whole body fat-free mass	0.2	0.9	2.0	0.4	1.4	0.8	0.8	1.4	0.5	0.8
Loneliness, isolation	0.2	0.3	0.7	-0.8	0.8	-0.4	0.2	-0.4	0.5	0.5
Osteoarthritis (self-reported)	0.2	0.2	0.7	0.1	0.6	0.0	0.7	0.8	-0.2	-0.1
Smoking status: Current	0.2	0.4	1.2	-0.3	0.2	-0.0	-0.8	-0.1	1.1	0.8
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.3	0.7	-0.6	-0.5	-0.3	-0.8	-0.6	-0.5	-0.7
Whole body water mass	0.2	1.0	2.1	0.4	1.4	0.8	1.0	1.4	0.6	0.9
Commuting to job workplace: Public transport	0.2	0.3	1.2	-0.6	0.1	-0.2	1.1	0.5	-0.3	-0.2
Pain type(s) experienced in last month: Hip pain	0.2	0.3	0.5	0.2	-0.4	-0.6	-0.5	-0.2	-0.6	-0.7
Medication: Paracetamol	0.2	0.4	0.8	-0.4	-0.2	-0.9	0.3	-0.6	0.8	0.8
Arm fat-free mass (left)	0.2	1.2	2.5	0.9	1.0	1.4	1.0	1.6	0.4	0.8
Unable to work because of sickness or disability	0.2	0.2	0.5	0.0	-0.2	-0.6	0.2	0.1	0.7	0.7
Leg fat mass (left)	0.2	0.8	2.6	1.3	-1.2	1.6	0.0	-0.1	-0.3	-0.1
Arm predicted mass (left)	0.2	1.0	2.0	0.9	0.9	1.4	1.0	1.4	0.3	0.7
Bipolar Disorder (2018)	0.1	0.2	1.0	-0.1	0.2	0.0	-1.0	-0.1	0.7	0.2
Neuroticism (Nagel 2018)	0.1	0.3	2.1	-0.2	0.2	-0.4	1.4	0.2	-0.1	0.1
Alzheimer’s Disease (in father)	0.1	0.1	0.2	-0.1	-0.2	-0.4	0.3	0.3	0.5	0.3
Ulcerative Colitis (UC)	0.1	0.3	1.1	-0.1	-0.4	-1.0	-0.5	-0.5	0.1	-0.2
Waist Hip Ratio (WHR)	0.1	0.4	0.9	-0.4	-0.4	0.3	0.2	0.7	0.9	0.8
Smoking Status	0.1	0.3	1.3	-1.1	-0.2	-0.7	-0.1	-0.4	-0.4	-0.4
Tanning	0.1	0.7	2.2	-0.2	-1.5	-0.8	-1.0	-0.9	0.1	-0.2
Hearing difficulty/problems: Yes	0.1	0.1	0.3	0.0	-0.1	0.1	0.5	-0.5	-0.2	0.1
Leg fat-free mass (left)	0.1	0.5	0.9	0.3	0.8	0.7	1.0	0.9	-0.0	0.3
Supplements: Glucosamine	0.1	0.1	0.4	0.2	-0.3	-0.0	0.6	-0.2	-0.7	-0.3
Medication: Atenolol	0.1	0.1	0.5	0.2	-0.1	-0.2	0.7	0.1	-0.5	-0.3
Leg predicted mass (left)	0.1	0.5	1.0	0.4	0.8	0.8	1.0	1.0	-0.1	0.3
Trunk fat mass	0.1	0.5	1.6	0.9	-0.6	1.3	0.3	-0.1	0.4	0.7
Waist circumference	0.1	0.5	1.8	0.6	-1.4	1.0	0.5	-0.0	-0.1	0.1
Nervous feelings	0.1	0.1	0.3	-0.2	0.2	-0.6	-0.1	-0.5	-0.0	-0.1
Had other major operations	0.1	0.2	0.7	-0.3	-0.8	-0.3	0.1	-0.2	-0.2	-0.4
Heart attack	0.1	0.2	0.4	0.6	-0.3	-0.0	0.6	0.1	-0.5	-0.3
Weight	0.1	0.5	1.3	0.8	-0.0	1.1	0.6	0.5	0.4	0.7
Arm fat mass (right)	0.1	0.6	2.3	0.1	-1.5	0.7	0.2	-0.8	-0.7	-0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.1	0.2	0.4	0.2	0.6	0.6	0.5	0.4	0.2	0.4
Wheeze or whistling in the chest in last year	0.1	0.2	0.8	0.1	-0.4	-0.8	-0.5	-0.9	-0.1	-0.0
Eye problems/disorders: None of the above	0.1	0.2	0.7	0.1	-0.3	0.8	0.4	-0.2	-0.3	-0.1
Medication: Seretide 50 evohaler	0.1	0.2	0.5	0.4	-0.1	0.7	0.1	0.1	0.4	0.5
Whole body fat mass	0.1	0.3	1.0	0.6	-1.0	0.9	-0.0	-0.5	-0.0	0.2
Comparative height size at age 10	0.1	0.6	1.2	-0.3	1.1	1.1	-1.0	0.5	0.5	0.3
Suffer from ‘nerves’	0.1	0.2	0.8	-0.5	0.9	0.0	-0.2	0.5	-0.1	-0.5
Had major operations	0.1	0.1	0.2	-0.2	-0.2	-0.2	0.3	-0.5	-0.3	0.0
Age at last live birth	0.1	0.1	0.5	-0.0	0.2	0.0	-0.6	-0.7	-0.0	-0.1
Leg pain on walking	0.1	0.1	0.3	0.3	0.1	-0.5	-0.5	-0.3	0.2	0.0
Leg fat-free mass (right)	0.1	0.7	1.9	0.4	1.4	0.6	0.8	1.2	0.2	0.5
Leg predicted mass (right)	0.1	0.7	2.0	0.3	1.4	0.7	0.9	1.2	0.2	0.5
Arm fat mass (left)	0.1	0.5	2.1	0.4	-1.4	0.8	0.3	-0.6	-0.5	-0.2
Mother’s age at death	0.1	0.2	0.5	-0.4	-0.1	-0.4	-0.2	-0.3	0.6	0.7
Basal metabolic rate	0.1	0.8	1.4	0.4	1.1	0.9	0.8	1.2	0.5	0.9
Average weekly beer plus cider intake	0.1	0.1	0.6	0.8	-0.4	0.2	0.2	0.2	0.2	0.1
Heart attack/myocardial infarction (self-reported)	0.1	0.1	0.4	0.6	-0.4	-0.2	0.4	0.1	-0.3	-0.2
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Hair Pigment	0.0	1.2	3.1	0.1	-0.2	0.2	1.8	1.2	-1.5	-1.3
Fed-up feelings	0.0	0.0	0.2	-0.0	0.3	0.1	0.4	-0.1	-0.1	-0.1
Hip circumference	0.0	0.2	0.5	0.2	-0.7	0.3	0.4	-0.5	-0.0	0.3
Irritability	0.0	0.1	0.3	-0.2	-0.0	-0.0	0.6	0.0	-0.2	-0.2
Cholesterol lowering medication	0.0	0.0	0.1	0.2	-0.2	-0.1	0.1	0.3	-0.0	0.0

Hub : Genes

ZNF483

Models

Trait associations